SEQUENCE LISTING



<110> Hyseq, Inc

<120>  NOVEL NUCLEIC ACIDS AND POLYPEPTIDES

<130>  21272-103

<140>  NOT YET ASSIGNED
<141>  2001-05-16

<150>  09/577,408
<151>  2000-05-18

<150>  09/677,298
<151>  2000-09-22

<150>  09/695,781
<151>  2000-10-24

<150>  09/715,869
<151>  2000-11-17

<150>  09/775,330
<151>  2001-02-01

<160>  864    

<170>  Custom


      <210> 1
      <211> 1019
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (154)..(966)

      <400> 1
 cgagcagggt gcggcggcgg cggggcgctc cggggaggcc aggacagctg atggttgtgg     60

 cagaaacatc tcaaggtagc tggtccgccc ccacttcccc atctacctct tgtcctcccc    120

 ccaacaccac caccaccctg gctcccctcc ctc atg acc gcc tgg atc ctc ctg     174
                                      Met Thr Ala Trp Ile Leu Leu
                                        1               5

 cct gtc agc ctg tca gcg ttc tcc atc act ggc ata tgg act gtg tat      222
 Pro Val Ser Leu Ser Ala Phe Ser Ile Thr Gly Ile Trp Thr Val Tyr
          10                  15                  20

 gcc atg gct gtg atg aac cac cat gta tgc cct gtg gag aac tgg tcc      270
 Ala Met Ala Val Met Asn His His Val Cys Pro Val Glu Asn Trp Ser
      25                  30                  35

 tac aac gag tcc tgc cct cct gac cct gct gag caa ggg ggt ccc aag      318
 Tyr Asn Glu Ser Cys Pro Pro Asp Pro Ala Glu Gln Gly Gly Pro Lys
  40                  45                  50                  55

 acc tgc tgc acc ctg gac gat gtc ccc ctc atc agc aag tgt ggc tcc      366
 Thr Cys Cys Thr Leu Asp Asp Val Pro Leu Ile Ser Lys Cys Gly Ser
                  60                  65                  70

 tat ccc cca gaa agc tgc ctc ttc agc ctc att ggc aac atg ggt gct      414
 Tyr Pro Pro Glu Ser Cys Leu Phe Ser Leu Ile Gly Asn Met Gly Ala
              75                  80                  85

 ttc atg gtg gcc ctg atc tgc ctc ctg cgc tac ggg cag ctc ctg gag      462
 Phe Met Val Ala Leu Ile Cys Leu Leu Arg Tyr Gly Gln Leu Leu Glu
          90                  95                 100

 cag agt cgg cac tct tgg gtt aac acc acg gca ctc atc aca ggc tgc      510
 Gln Ser Arg His Ser Trp Val Asn Thr Thr Ala Leu Ile Thr Gly Cys
     105                 110                 115

 acc aac gct gcg ggc ctc ttg gtg gtt ggc aac ttt cag gtg gat cat      558
 Thr Asn Ala Ala Gly Leu Leu Val Val Gly Asn Phe Gln Val Asp His
 120                 125                 130                 135

 gcc agg tct ctg cac tac gtt gga gct ggc gtg gcc ttc cct gcg ggg      606
 Ala Arg Ser Leu His Tyr Val Gly Ala Gly Val Ala Phe Pro Ala Gly
                 140                 145                 150

 ctg ctc ttt gtt tgc ctg cac tgt gct ctc tcc tac caa ggg gcc acc      654
 Leu Leu Phe Val Cys Leu His Cys Ala Leu Ser Tyr Gln Gly Ala Thr
             155                 160                 165

 gcc ccg ctg gac ctg gct gtg gcc tat ctg cga agt gtg ctg gct gtc      702
 Ala Pro Leu Asp Leu Ala Val Ala Tyr Leu Arg Ser Val Leu Ala Val
         170                 175                 180

 atc gcc ttt atc acc ctg gtc ctc agt gga gtc ttc ttt gtc cat gag      750
 Ile Ala Phe Ile Thr Leu Val Leu Ser Gly Val Phe Phe Val His Glu
     185                 190                 195

 agt tct cag ctg caa cat ggg gca gcc ctg tgt gag tgg gtg tgt gtc      798
 Ser Ser Gln Leu Gln His Gly Ala Ala Leu Cys Glu Trp Val Cys Val
 200                 205                 210                 215

 atc gat atc ctc att ttc tat ggc acc ttc agc tac gag ttt ggg gca      846
 Ile Asp Ile Leu Ile Phe Tyr Gly Thr Phe Ser Tyr Glu Phe Gly Ala
                 220                 225                 230

 gtc tcc tca gac aca ctg gtg gct gca ctg cag cct acc cct ggc cgg      894
 Val Ser Ser Asp Thr Leu Val Ala Ala Leu Gln Pro Thr Pro Gly Arg
             235                 240                 245

 gcc tgc aag tcc tcc ggg agc agc agc acc tcc acc cac ctc aac tgt      942
 Ala Cys Lys Ser Ser Gly Ser Ser Ser Thr Ser Thr His Leu Asn Cys
         250                 255                 260

 gcc ccc gag agc atc gct atg atc taaggtctgg ggagggtggc tggcccggcc     996
 Ala Pro Glu Ser Ile Ala Met Ile 
     265                 270

 tccacagcac cccaccccat atc                                           1019




      <210> 2
      <211> 1182
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (157)..(867)

      <220>
      <221> misc_feature
      <222> (1)...(1182)
      <223> n = a,t,c or g

      <400> 2
 accatcgtcc angtccncgg attctccggc gcaccgtacg ctgggacgtg tggtttcagc     60

 tcgtgcgcct ccttgtgggt ttttgacgtt tagcgactat tgcgcctgcg ccagcgccgg    120

 ctgcgagact ggggccgtgg ctgctggtcc cgggtg  atg cta ggc ggc tcc ctg     174
                                          Met Leu Gly Gly Ser Leu
                                            1               5

 ggc tcc agg ctg ttg cgg ggt gta ggt ggg agt cac gga cgg ttc ggg      222
 Gly Ser Arg Leu Leu Arg Gly Val Gly Gly Ser His Gly Arg Phe Gly
              10                  15                  20

 gcc cga ggt gtc cgc gaa ggt ggc gca gcc atg gcg gca ggg gag agc      270
 Ala Arg Gly Val Arg Glu Gly Gly Ala Ala Met Ala Ala Gly Glu Ser
          25                  30                  35

 atg gct cag cgg atg gtc tgg gtg gac ctg gag atg aca gga ttg gac      318
 Met Ala Gln Arg Met Val Trp Val Asp Leu Glu Met Thr Gly Leu Asp
      40                  45                  50

 att gag aag gac cag att att gag atg gcc tgt ctg ata act gac tct      366
 Ile Glu Lys Asp Gln Ile Ile Glu Met Ala Cys Leu Ile Thr Asp Ser
  55                  60                  65                  70

 gat ctc aac att ttg gct gaa ggt cct aac ctg att ata aaa caa cca      414
 Asp Leu Asn Ile Leu Ala Glu Gly Pro Asn Leu Ile Ile Lys Gln Pro
                  75                  80                  85

 gat gag ttg ctg gac agc atg tca gat tgg tgt aag gag cat cac ggg      462
 Asp Glu Leu Leu Asp Ser Met Ser Asp Trp Cys Lys Glu His His Gly
              90                  95                 100

 aag tct ggc ctt acc aag gca gtg aag gag agt aca att aca ttg cag      510
 Lys Ser Gly Leu Thr Lys Ala Val Lys Glu Ser Thr Ile Thr Leu Gln
         105                 110                 115

 cag gca gag tat gaa ttt ctg tcc ttt gta cga cag cag act cct cca      558
 Gln Ala Glu Tyr Glu Phe Leu Ser Phe Val Arg Gln Gln Thr Pro Pro
     120                 125                 130

 ggg ctc tgt cca ctt gca gga aat tca gtt cat gaa gat aag aag ttt      606
 Gly Leu Cys Pro Leu Ala Gly Asn Ser Val His Glu Asp Lys Lys Phe
 135                 140                 145                 150

 ctt gac aaa tac atg ccc cag ttc atg aaa cat ctt cat tat aga ata      654
 Leu Asp Lys Tyr Met Pro Gln Phe Met Lys His Leu His Tyr Arg Ile
                 155                 160                 165

 att gat gtg agc act gtt aaa gaa ctg tgc aga cgc tgg tat cca gaa      702
 Ile Asp Val Ser Thr Val Lys Glu Leu Cys Arg Arg Trp Tyr Pro Glu
             170                 175                 180

 gaa tat gaa ttt gca cca aag aag gct gct tct cat agg gca ctt gat      750
 Glu Tyr Glu Phe Ala Pro Lys Lys Ala Ala Ser His Arg Ala Leu Asp
         185                 190                 195

 gac att agt gaa agc atc aaa gag ctt cag ttt tac cga aat aac atc      798
 Asp Ile Ser Glu Ser Ile Lys Glu Leu Gln Phe Tyr Arg Asn Asn Ile
     200                 205                 210

 ttc aag aaa aaa ata gat gaa aag aag agg aaa att ata gaa aat ggg      846
 Phe Lys Lys Lys Ile Asp Glu Lys Lys Arg Lys Ile Ile Glu Asn Gly
 215                 220                 225                 230

 gaa aat gag aag acc gtg agt tg atgccagtta tcatgctgcc actacatcgt      899
 Glu Asn Glu Lys Thr Val Ser 
                 235

 tatctggagg caacttctgg tggttttttt ttctcacgct gatggcttgg cagagcacct    959

 tcggttaact tgcatctcca gattgattac tcaagcagac agcacacgaa atactatttt   1019

 tctcctaata tgctgtttcc attatgacac agcagctcct ttgtaagtac caggtcatgt   1079

 ccatcccttg gtacatatat gcatttgctt ttaaaccatt tcttttgttt aaataaataa   1139

 ataagtaaat aaagctagtt ctattgaaat gcaaaaaaaa aaa                     1182




      <210> 3
      <211> 1295
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (79)..(1080)

      <400> 3
 gtccgcgcac gcagctgact ttgtcttctc cgcacgactg ttacagaggt ctccagagcc     60

 ttctctctcc tgtgcaaa  atg gca act ctt aag gaa aaa ctc att gca cca     111
                      Met Ala Thr Leu Lys Glu Lys Leu Ile Ala Pro
                        1               5                  10

 gtt gcg gaa gaa gag gca aca gtt cca aac aat aag atc act gta gtg      159
 Val Ala Glu Glu Glu Ala Thr Val Pro Asn Asn Lys Ile Thr Val Val
              15                  20                  25

 ggt gtt gga caa gtt ggt atg gcg tgt gct atc agc att ctg gga aag      207
 Gly Val Gly Gln Val Gly Met Ala Cys Ala Ile Ser Ile Leu Gly Lys
          30                  35                  40

 tct ctg gct gat gaa ctt gct ctt gtg gat gtt ttg gaa gat aag ctt      255
 Ser Leu Ala Asp Glu Leu Ala Leu Val Asp Val Leu Glu Asp Lys Leu
      45                  50                  55

 aaa gga gaa atg atg gat ctg cag cat ggg agc tta ttt ctt cag aca      303
 Lys Gly Glu Met Met Asp Leu Gln His Gly Ser Leu Phe Leu Gln Thr
  60                  65                  70                  75

 cct aaa att gtg gca gat aaa gat tat tct gtg acc gcc aat tct aag      351
 Pro Lys Ile Val Ala Asp Lys Asp Tyr Ser Val Thr Ala Asn Ser Lys
                  80                  85                  90

 att gta gtg gta act gca gga gtc cgt cag caa gaa ggg gag agt cgg      399
 Ile Val Val Val Thr Ala Gly Val Arg Gln Gln Glu Gly Glu Ser Arg
              95                 100                 105

 ctc aat ctg gtg cag aga aat gtt aat gtc ttc aaa ttc att att cct      447
 Leu Asn Leu Val Gln Arg Asn Val Asn Val Phe Lys Phe Ile Ile Pro
         110                 115                 120

 cag atc gtc aag tac agt cct gat tgc atc ata att gtg gtt tcc aac      495
 Gln Ile Val Lys Tyr Ser Pro Asp Cys Ile Ile Ile Val Val Ser Asn
     125                 130                 135

 cca gtg gac att ctt acg tat gtt acc tgg aaa cta agt gga tta ccc      543
 Pro Val Asp Ile Leu Thr Tyr Val Thr Trp Lys Leu Ser Gly Leu Pro
 140                 145                 150                 155

 aaa cac cgc gtg att gga agt gga tgt aat ctg gat tct gct aga ttt      591
 Lys His Arg Val Ile Gly Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe
                 160                 165                 170

 cgc tac ctt atg gct gaa aaa ctt ggc att cat ccc agc agc tgc cat      639
 Arg Tyr Leu Met Ala Glu Lys Leu Gly Ile His Pro Ser Ser Cys His
             175                 180                 185

 gga tgg att ttg ggg gaa cat ggc gac tca agt gtg gct gtg tgg agt      687
 Gly Trp Ile Leu Gly Glu His Gly Asp Ser Ser Val Ala Val Trp Ser
         190                 195                 200

 ggt gtg aat gtg gca ggt gtt tct ctc cag gaa ttg aat cca gaa atg      735
 Gly Val Asn Val Ala Gly Val Ser Leu Gln Glu Leu Asn Pro Glu Met
     205                 210                 215

 gga act gac aat gat agt gaa aat tgg aag gaa gtg cat aag atg gtg      783
 Gly Thr Asp Asn Asp Ser Glu Asn Trp Lys Glu Val His Lys Met Val
 220                 225                 230                 235

 gtt gaa agt gcc tat gaa gtc atc aag cta aaa gga tat acc aac tgg      831
 Val Glu Ser Ala Tyr Glu Val Ile Lys Leu Lys Gly Tyr Thr Asn Trp
                 240                 245                 250

 gct att gga tta agt gtg gct gat ctt att gaa tcc atg ttg aaa aat      879
 Ala Ile Gly Leu Ser Val Ala Asp Leu Ile Glu Ser Met Leu Lys Asn
             255                 260                 265

 cta tcc agg att cat ccc gtg tca aca atg gta aag ggg atg tat ggc      927
 Leu Ser Arg Ile His Pro Val Ser Thr Met Val Lys Gly Met Tyr Gly
         270                 275                 280

 att gag aat gaa gtc ttc ctg agc ctt cca tgt atc ctc aat gcc cgg      975
 Ile Glu Asn Glu Val Phe Leu Ser Leu Pro Cys Ile Leu Asn Ala Arg
     285                 290                 295

 gga tta acc agc gtt atc aac cag aag cta aag gat gat gag gtt gct     1023
 Gly Leu Thr Ser Val Ile Asn Gln Lys Leu Lys Asp Asp Glu Val Ala
 300                 305                 310                 315

 cag ctc aag aaa agt gca gat acc ctg tgg gac atc cag aag gac cta     1071
 Gln Leu Lys Lys Ser Ala Asp Thr Leu Trp Asp Ile Gln Lys Asp Leu
                 320                 325                 330

 aaa gac ctg tgactag tgagctctag gctgtagaaa tttaaaaact acaatgtgat     1127
 Lys Asp Leu 


 taactcgagc ctttagtttt catccatgta catggatcac agtttgcttt gatcttcttc   1187

 aatatgtgaa tttgggctca cagaatcaaa gcctatgctt ggtttaatgc ttgcaatctg   1247

 agctcttgaa caaataaaat taactattgt agtgtgaaaa aaaaaaaa                1295




      <210> 4
      <211> 1617
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (65)..(1342)

      <400> 4
 tggagtctga gccggcgccg ctcagtgtga ggtggtttct gcgggtgagg ctggcgcccg     60

 tacc atg agc gag gcg gac ggg ctg cga cag cgc cgg ccc ctg cgg ccg     109
      Met Ser Glu Ala Asp Gly Leu Arg Gln Arg Arg Pro Leu Arg Pro
        1               5                  10                  15

 cag gtc gtc aca gac gat gat ggc cag gcc ccg gag gct aag gac ggc      157
 Gln Val Val Thr Asp Asp Asp Gly Gln Ala Pro Glu Ala Lys Asp Gly
                  20                  25                  30

 agc tcc ttt agc ggc aga gtt ttc cga gtg acc ttc ttg atg ctg gct      205
 Ser Ser Phe Ser Gly Arg Val Phe Arg Val Thr Phe Leu Met Leu Ala
              35                  40                  45

 gtt tct ctc acc gtt ccc ctg ctt gga gcc atg atg ctg ctg gaa tct      253
 Val Ser Leu Thr Val Pro Leu Leu Gly Ala Met Met Leu Leu Glu Ser
          50                  55                  60

 cct ata gat cca cag cct ctc aga cag atc tct gga att gca tta ttt      301
 Pro Ile Asp Pro Gln Pro Leu Arg Gln Ile Ser Gly Ile Ala Leu Phe
      65                  70                  75

 tgc agc ttc aaa gaa ccc ccg ctc ttg ctt ggt gtt ctg cat cca aat      349
 Cys Ser Phe Lys Glu Pro Pro Leu Leu Leu Gly Val Leu His Pro Asn
  80                  85                  90                  95

 acg aag ctg cga cag gca gaa agg ctg ttt gaa aat caa ctt gtt gga      397
 Thr Lys Leu Arg Gln Ala Glu Arg Leu Phe Glu Asn Gln Leu Val Gly
                 100                 105                 110

 ccg gag tcc ata gca cat att ggg gat gtg atg ttt act ggg aca gca      445
 Pro Glu Ser Ile Ala His Ile Gly Asp Val Met Phe Thr Gly Thr Ala
             115                 120                 125

 gat ggc cgg gtc gta aaa ctt gaa aat ggt gaa ata gag acc att gcc      493
 Asp Gly Arg Val Val Lys Leu Glu Asn Gly Glu Ile Glu Thr Ile Ala
         130                 135                 140

 cgg ttt ggt tcg ggc cct tgc aaa acc cga gat gat gag cct gtg tgt      541
 Arg Phe Gly Ser Gly Pro Cys Lys Thr Arg Asp Asp Glu Pro Val Cys
     145                 150                 155

 ggg aga ccc ctg ggt atc cgt gca ggg ccc aat ggg act ctc ttt gtg      589
 Gly Arg Pro Leu Gly Ile Arg Ala Gly Pro Asn Gly Thr Leu Phe Val
 160                 165                 170                 175

 gcc gat gca tac aag gga cta ttt gaa gta aat ccc tgg aaa cgt gaa      637
 Ala Asp Ala Tyr Lys Gly Leu Phe Glu Val Asn Pro Trp Lys Arg Glu
                 180                 185                 190

 gtg aaa ctg ctg ctg tcc tcc gag aca ccc att gag ggg aag aac atg      685
 Val Lys Leu Leu Leu Ser Ser Glu Thr Pro Ile Glu Gly Lys Asn Met
             195                 200                 205

 tcc ttt gtg aat gat ctt aca gtc act cag gat ggg agg aag att tat      733
 Ser Phe Val Asn Asp Leu Thr Val Thr Gln Asp Gly Arg Lys Ile Tyr
         210                 215                 220

 ttc acc gat tct agc agc aaa tgg caa aga cga gac tac ctg ctt ctg      781
 Phe Thr Asp Ser Ser Ser Lys Trp Gln Arg Arg Asp Tyr Leu Leu Leu
     225                 230                 235

 gtg atg gag ggc aca gat gac ggg cgc ctg ctg gag tat gat act gtg      829
 Val Met Glu Gly Thr Asp Asp Gly Arg Leu Leu Glu Tyr Asp Thr Val
 240                 245                 250                 255

 acc agg gaa gta aaa gtt tta ttg gac cag ctg cgg ttc ccg aat gga      877
 Thr Arg Glu Val Lys Val Leu Leu Asp Gln Leu Arg Phe Pro Asn Gly
                 260                 265                 270

 gtc cag ctg tct cct gca gaa gac ttt gtc ctg gtg gca gaa aca acc      925
 Val Gln Leu Ser Pro Ala Glu Asp Phe Val Leu Val Ala Glu Thr Thr
             275                 280                 285

 atg gcc agg ata cga aga gtc tac gtt tct ggc ctg atg aag ggc ggg      973
 Met Ala Arg Ile Arg Arg Val Tyr Val Ser Gly Leu Met Lys Gly Gly
         290                 295                 300

 gct gat ctg ttt gtg gag aac atg cct gga ttt cca gac aac atc cgg     1021
 Ala Asp Leu Phe Val Glu Asn Met Pro Gly Phe Pro Asp Asn Ile Arg
     305                 310                 315

 ccc agc agc tct ggg ggg tac tgg gtg ggc atg tcg acc atc cgc cct     1069
 Pro Ser Ser Ser Gly Gly Tyr Trp Val Gly Met Ser Thr Ile Arg Pro
 320                 325                 330                 335

 aac cct ggg ttt tcc atg ctg gat ttc tta tct gag aga ccc tgg att     1117
 Asn Pro Gly Phe Ser Met Leu Asp Phe Leu Ser Glu Arg Pro Trp Ile
                 340                 345                 350

 aaa agg atg att ttt aag ctc ttt agt caa gag acg gtg atg aag ttt     1165
 Lys Arg Met Ile Phe Lys Leu Phe Ser Gln Glu Thr Val Met Lys Phe
             355                 360                 365

 gtg ccg cgg tac agc ctc gtc cta gaa ctc agc gac agc ggt gcc ttc     1213
 Val Pro Arg Tyr Ser Leu Val Leu Glu Leu Ser Asp Ser Gly Ala Phe
         370                 375                 380

 cgg aga agc ctg cat gat ccc gat ggg ctg gtg gcc acc tac atc agc     1261
 Arg Arg Ser Leu His Asp Pro Asp Gly Leu Val Ala Thr Tyr Ile Ser
     385                 390                 395

 gag gtg cac gaa cac gat ggg cac ctg tac ctg ggc tct ttc agg tcc     1309
 Glu Val His Glu His Asp Gly His Leu Tyr Leu Gly Ser Phe Arg Ser
 400                 405                 410                 415

 ccc ttc ctc tgc aga ctc agc ctc cag gct gtt tagccctc ccagatagct     1360
 Pro Phe Leu Cys Arg Leu Ser Leu Gln Ala Val 
                 420                 425

 gcccctgcca cgcaggccag gagtcttcac actcaggcac caggcctggt ccaggaggag   1420

 ctgtggacac agtcgtggtt caagtgtcca catgcacctg ttagtccctg agaggtggtg   1480

 ggaatggctg cttcattcct cgaggatgcc cgggccccac ctgggcttgt ctttctgttt   1540

 agagggaagt gtaacatatc tgccatgagg aacataaatt catgtaaagc cattttctct   1600

 taaacaaaaa aaaaaaa                                                  1617




      <210> 5
      <211> 1476
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (248)..(1174)

      <400> 5
 gctgctggag ctgcagcccg accgcgagcg tgccaagcgg cttcagcagc tagcggacgt     60

 ggcggcggcc cccctcagga caccaccaga ttcccctctt cccgcggcct cgccatggcg    120

 acccacggac agacttgcgc gcgtcgatcg gatcaatcac ttttctagag gaagtagcag    180

 tccctcttgt gagagcgcaa ggtcattact tgtgctccta agggcgtgga cgtgctttgt    240

 ggaatga  atg agc tgg tgt aat gag ctc aga ttg cct gcc ctt aag cag     289
          Met Ser Trp Cys Asn Glu Leu Arg Leu Pro Ala Leu Lys Gln
            1               5                  10

 cac agc att ggc cga gga ctt gag agt cac att aca atg tgt att cct      337
 His Ser Ile Gly Arg Gly Leu Glu Ser His Ile Thr Met Cys Ile Pro
  15                  20                  25                  30

 cca tca tat gct gac ctt ggc aaa gct gcc aga gat att ttc aac aaa      385
 Pro Ser Tyr Ala Asp Leu Gly Lys Ala Ala Arg Asp Ile Phe Asn Lys
                  35                  40                  45

 gga ttt ggt ttt ggg ttg gtg aaa ctg gat gtg aaa aca aag tct tgc      433
 Gly Phe Gly Phe Gly Leu Val Lys Leu Asp Val Lys Thr Lys Ser Cys
              50                  55                  60

 agt ggc gtg gaa ttt tca acg tcc ggt tca tct aat aca gac act ggt      481
 Ser Gly Val Glu Phe Ser Thr Ser Gly Ser Ser Asn Thr Asp Thr Gly
          65                  70                  75

 aaa gtt act ggg acc ttg gag acc aaa tac aag tgg tgt gag tat ggt      529
 Lys Val Thr Gly Thr Leu Glu Thr Lys Tyr Lys Trp Cys Glu Tyr Gly
      80                  85                  90

 ctg act ttc aca gaa aag tgg aac act gat aac act ctg gga aca gaa      577
 Leu Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr Leu Gly Thr Glu
  95                 100                 105                 110

 atc gca att gaa gac cag att tgt caa ggt ttg aaa ctg aca ttt gat      625
 Ile Ala Ile Glu Asp Gln Ile Cys Gln Gly Leu Lys Leu Thr Phe Asp
                 115                 120                 125

 act acc ttc tca cca aac aca gga aag aaa agt ggt aaa atc aag tct      673
 Thr Thr Phe Ser Pro Asn Thr Gly Lys Lys Ser Gly Lys Ile Lys Ser
             130                 135                 140

 tct tac aag agg gag tgt ata aac ctt ggt tgt gat gtt gac ttt gat      721
 Ser Tyr Lys Arg Glu Cys Ile Asn Leu Gly Cys Asp Val Asp Phe Asp
         145                 150                 155

 ttt gct gga cct gca atc cat ggt tca gct gtc ttt ggt tat gag ggc      769
 Phe Ala Gly Pro Ala Ile His Gly Ser Ala Val Phe Gly Tyr Glu Gly
     160                 165                 170

 tgg ctt gct ggc tac cag atg acc ttt gac agt gcc aaa tca aag ctg      817
 Trp Leu Ala Gly Tyr Gln Met Thr Phe Asp Ser Ala Lys Ser Lys Leu
 175                 180                 185                 190

 aca agg aat aac ttt gca gtg ggc tac agg act ggg gac ttc cag cta      865
 Thr Arg Asn Asn Phe Ala Val Gly Tyr Arg Thr Gly Asp Phe Gln Leu
                 195                 200                 205

 cac act aat gtc aat gat ggg aca gaa ttt gga gga tca att tat cag      913
 His Thr Asn Val Asn Asp Gly Thr Glu Phe Gly Gly Ser Ile Tyr Gln
             210                 215                 220

 aaa gtt tgt gaa gat ctt gac act tca gta aac ctt gct tgg aca tca      961
 Lys Val Cys Glu Asp Leu Asp Thr Ser Val Asn Leu Ala Trp Thr Ser
         225                 230                 235

 ggt acc aac tgc act cgt ttt ggc att gca gct aaa tat cag ttg gat     1009
 Gly Thr Asn Cys Thr Arg Phe Gly Ile Ala Ala Lys Tyr Gln Leu Asp
     240                 245                 250

 ccc act gct tcc att tct gca aaa gtc aac aac tct agc tta att gga     1057
 Pro Thr Ala Ser Ile Ser Ala Lys Val Asn Asn Ser Ser Leu Ile Gly
 255                 260                 265                 270

 gta ggc tat act cag act ctg agg cct ggt gtg aag ctt aca ctc tct     1105
 Val Gly Tyr Thr Gln Thr Leu Arg Pro Gly Val Lys Leu Thr Leu Ser
                 275                 280                 285

 gct ctg gta gat ggg aag agc att aat gct gga ggc cac aag gtt ggg     1153
 Ala Leu Val Asp Gly Lys Ser Ile Asn Ala Gly Gly His Lys Val Gly
             290                 295                 300

 ctc gcc ctg gag ttg gag gct ta atccagctga aagaaacctt tgggaatgga     1206
 Leu Ala Leu Glu Leu Glu Ala 
         305

 tatcagaaga tttggcctta atatatttcc attgtgacca gcagcaggct tttttccccc   1266

 cagaagatga tcaaaacaaa ggatgatctc aacaagagct gtattttaag tatttagaca   1326

 gttctttgtt agctggtttc tagttggtta tctagttacc aatgctgcag tcctgcagtc   1386

 acctatacat tatttaaatg tatttaactg ttaaatgcgc tacccaccaa taatgaaata   1446

 gacctttatg aaaactgtga aaaaaaaaaa                                    1476




      <210> 6
      <211> 789
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (158)..(565)

      <400> 6
 gctccactta ccaggccgcg gctaccccgc cgtccccccc gactcccgcc accccgctct     60

 ctcaggctct tcaggatcca agtccgtagg ccctttaagg ggtctagttg ccgtttgcga    120

 ggccctggga ctttggtccc agacagcggg gatccgg atg gct tcc gtg cgg atc     175
                                          Met Ala Ser Val Arg Ile
                                            1               5

 cga gag gcc aag gag gga gac tgt gga gat atc ctg agg ctg att cgg      223
 Arg Glu Ala Lys Glu Gly Asp Cys Gly Asp Ile Leu Arg Leu Ile Arg
              10                  15                  20

 gag cta gcc gaa ttc gaa aaa ctc tcg gat cag gtg aag atc agt gaa      271
 Glu Leu Ala Glu Phe Glu Lys Leu Ser Asp Gln Val Lys Ile Ser Glu
          25                  30                  35

 gaa gcc ctg aga gca gat ggc ttt gga gac aat cct ttc tat cac tgt      319
 Glu Ala Leu Arg Ala Asp Gly Phe Gly Asp Asn Pro Phe Tyr His Cys
      40                  45                  50

 ttg gta gca gag att ctt cca gcg ccc ggg aag cta ctg ggt caa ggg      367
 Leu Val Ala Glu Ile Leu Pro Ala Pro Gly Lys Leu Leu Gly Gln Gly
  55                  60                  65                  70

 att ggt tcc aaa ata atc aaa aag gtg gct gag gtg gcc ttg gat aag      415
 Ile Gly Ser Lys Ile Ile Lys Lys Val Ala Glu Val Ala Leu Asp Lys
                  75                  80                  85

 ggc tgc tcc caa ttc cgc ctg gcc gtc ctg gac tgg aac cag agg gcc      463
 Gly Cys Ser Gln Phe Arg Leu Ala Val Leu Asp Trp Asn Gln Arg Ala
              90                  95                 100

 atg gac ttg tac aag gcc cta gga gcc caa gat ctg acg gaa gct gag      511
 Met Asp Leu Tyr Lys Ala Leu Gly Ala Gln Asp Leu Thr Glu Ala Glu
         105                 110                 115

 ggc tgg cac ttt ttt tgc ttt caa gga gag gca acg aga aag ttg gca      559
 Gly Trp His Phe Phe Cys Phe Gln Gly Glu Ala Thr Arg Lys Leu Ala
     120                 125                 130

 gga aag tgacgccatc cctaggagga tttctgtctt gagtttttcc ttccccatca       615
 Gly Lys 
 135

 gctgaagcac ttttcagaga ctacgtccac agacactgat gctgaggcct ccctggagga    675

 aggagggtta ggggtgccta tcctcaagta ttggaagagc agaattgagg gagagacctt    735

 ttttccttgt tgagggtgaa aaataaataa gaattacatg tcaaaaaaaa aaaa          789




      <210> 7
      <211> 520
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (90)..(395)

      <400> 7
 actactacta ctaaattcgc ggccggtcga ccttcgccag gctctctgct gactcaagtt     60

 cttcagttca cgatcttcta gttgcagcg  atg agt gca cga gtg aga tca aga     113
                                  Met Ser Ala Arg Val Arg Ser Arg
                                    1               5

 tcc aga gga aga gga gat ggt cag gag gct ccc gat gtg gtt gca ttc      161
 Ser Arg Gly Arg Gly Asp Gly Gln Glu Ala Pro Asp Val Val Ala Phe
      10                  15                  20

 gtg gct ccc ggt gaa tct cag caa gag gaa cca cca act gac aat cag      209
 Val Ala Pro Gly Glu Ser Gln Gln Glu Glu Pro Pro Thr Asp Asn Gln
  25                  30                  35                  40

 gat att gaa cct gga caa gag aga gaa gga aca cct ccg atc gaa gaa      257
 Asp Ile Glu Pro Gly Gln Glu Arg Glu Gly Thr Pro Pro Ile Glu Glu
                  45                  50                  55

 cgt aaa gta gaa ggt gat tgc cag gaa atg gat ctg gaa aag act cgg      305
 Arg Lys Val Glu Gly Asp Cys Gln Glu Met Asp Leu Glu Lys Thr Arg
              60                  65                  70

 agt gag cgt gga gat ggc tct gat gta aaa gag aag act cca cct aat      353
 Ser Glu Arg Gly Asp Gly Ser Asp Val Lys Glu Lys Thr Pro Pro Asn
          75                  80                  85

 cct aag cat gct aag act aaa gaa gca gga gat ggg cag cca taagtta      402
 Pro Lys His Ala Lys Thr Lys Glu Ala Gly Asp Gly Gln Pro 
      90                  95                 100

 aaaagaagac aagctgaagc tacacacatg gctgatgtca cattgaaaat gtgactgaaa    462

 atttgaaaat tctctcaata aagtttgagt tttctctgaa gaaaaaaaaa aaaaaaaa      520




      <210> 8
      <211> 4440
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (650)..(4135)

      <400> 8
 tcaacatatg aaaaatcaat gtaatatttc atattaacag ttggaagact cacaattcat     60

 agtttcagaa tttacaacac aaacctacag gaataaagac aatgtagtat tagaataagg    120

 tcagatatat agatcaatgg acagaattga cagtccagaa atacacccat acgattacgg    180

 tcacctgatt tttgactaag gttccaaaac aattcactag gggaaagaat agtcttgtca    240

 aaaaatggtg ctcagacaag tggatagcca taagcacaga atgagtttgg acccctatct    300

 caaatctcaa atacaaacat taactccgaa ttaatcaaat gcctaaattt aagagctaaa    360

 attttaaagc tcttagaaga aaacataggt acacatcttt gtgactttga attaggtcac    420

 ggtttccttg acatgacact taaaagtaca agcaacaaaa gaaaaaaata gataaaatga    480

 acttcagcaa aattagaatg tttatgcttc agaaaacact gtgaagaaag tgatcagaca    540

 actcacagaa tgggaaaaat atttgtgaat catatctctt aataagggtc cagcagaaaa    600

 gggcaaaggt ggaaatggag gaggaaaacc tccttctggt ccaaaccga    atg aat     655
                                                          Met Asn
                                                            1

 ggt cat cac caa cag aat gga gtg gaa aac atg atg ttg ttt gaa gtt      703
 Gly His His Gln Gln Asn Gly Val Glu Asn Met Met Leu Phe Glu Val
           5                  10                  15

 gtt aaa atg ggc aag agt gct atg cag tcg gtg gta gat gat tgg ata      751
 Val Lys Met Gly Lys Ser Ala Met Gln Ser Val Val Asp Asp Trp Ile
      20                  25                  30

 gaa tca tac aag cat gac cga gat ata gca ctt ctt gac ctt atc aac      799
 Glu Ser Tyr Lys His Asp Arg Asp Ile Ala Leu Leu Asp Leu Ile Asn
  35                  40                  45                  50

 ttt ttt att cag tgt tca ggc tgt aaa gga gtt gtc aca gca gaa atg      847
 Phe Phe Ile Gln Cys Ser Gly Cys Lys Gly Val Val Thr Ala Glu Met
                  55                  60                  65

 ttt aga cat atg cag aac tct gag ata att cga aaa atg act gaa gaa      895
 Phe Arg His Met Gln Asn Ser Glu Ile Ile Arg Lys Met Thr Glu Glu
              70                  75                  80

 ttc gat gag gat agt gga gat tat cca ctt acc atg gct ggt cct cag      943
 Phe Asp Glu Asp Ser Gly Asp Tyr Pro Leu Thr Met Ala Gly Pro Gln
          85                  90                  95

 tgg aag aag ttc aaa tcc agt ttt tgt gaa ttc att ggc gtg tta gta      991
 Trp Lys Lys Phe Lys Ser Ser Phe Cys Glu Phe Ile Gly Val Leu Val
     100                 105                 110

 cgg caa tgt caa tat agt atc ata tat gat gag tat atg atg gat aca     1039
 Arg Gln Cys Gln Tyr Ser Ile Ile Tyr Asp Glu Tyr Met Met Asp Thr
 115                 120                 125                 130

 gtc att tca ctt ctt aca gga ttg tct gac tca caa gtc aga gca ttt     1087
 Val Ile Ser Leu Leu Thr Gly Leu Ser Asp Ser Gln Val Arg Ala Phe
                 135                 140                 145

 cga cat aca agc acc ctg gca gct atg aag ttg atg aca gct ttg gtg     1135
 Arg His Thr Ser Thr Leu Ala Ala Met Lys Leu Met Thr Ala Leu Val
             150                 155                 160

 aat gtg gca cta aat ctt agc att aat atg gat aat aca caa aga caa     1183
 Asn Val Ala Leu Asn Leu Ser Ile Asn Met Asp Asn Thr Gln Arg Gln
         165                 170                 175

 tat gaa gca gaa cga aat aaa atg att ggg aaa cga gcc aat gag agg     1231
 Tyr Glu Ala Glu Arg Asn Lys Met Ile Gly Lys Arg Ala Asn Glu Arg
     180                 185                 190

 cta gaa ctc ctg cta caa aag cgg aaa gag ctt cag gaa aat caa gat     1279
 Leu Glu Leu Leu Leu Gln Lys Arg Lys Glu Leu Gln Glu Asn Gln Asp
 195                 200                 205                 210

 gaa ata gaa aat atg atg aat gca ata ttt aaa gga gtg ttt gta cat     1327
 Glu Ile Glu Asn Met Met Asn Ala Ile Phe Lys Gly Val Phe Val His
                 215                 220                 225

 aga tac cgt gat gcg ata cgt gaa att cga gct att tgc att gaa gag     1375
 Arg Tyr Arg Asp Ala Ile Arg Glu Ile Arg Ala Ile Cys Ile Glu Glu
             230                 235                 240

 att ggc att tgg atg aag atg tat agt gat gcc ttt ctt aat gac agt     1423
 Ile Gly Ile Trp Met Lys Met Tyr Ser Asp Ala Phe Leu Asn Asp Ser
         245                 250                 255

 tat tta aaa tat gtt ggt tgg act atg cat gat aag caa ggt gaa gta     1471
 Tyr Leu Lys Tyr Val Gly Trp Thr Met His Asp Lys Gln Gly Glu Val
     260                 265                 270

 aga ctc aaa tgt ctt act gct cta caa ggg ctt tat tat aac aaa gag     1519
 Arg Leu Lys Cys Leu Thr Ala Leu Gln Gly Leu Tyr Tyr Asn Lys Glu
 275                 280                 285                 290

 ctt aat tcc aaa ctg gaa ctt ttt acc agt cgg ttc aag gat aga att     1567
 Leu Asn Ser Lys Leu Glu Leu Phe Thr Ser Arg Phe Lys Asp Arg Ile
                 295                 300                 305

 gtg tct atg acc ctt gac aaa gaa tat gat gtt gca gta caa gca ata     1615
 Val Ser Met Thr Leu Asp Lys Glu Tyr Asp Val Ala Val Gln Ala Ile
             310                 315                 320

 aaa tta ctc act ctt gtt tta cag agt agt gaa gaa gtt ctc act gca     1663
 Lys Leu Leu Thr Leu Val Leu Gln Ser Ser Glu Glu Val Leu Thr Ala
         325                 330                 335

 gaa gat tgt gaa aat gtc tat cat ctg gtt tat tca gct cac cgg cca     1711
 Glu Asp Cys Glu Asn Val Tyr His Leu Val Tyr Ser Ala His Arg Pro
     340                 345                 350

 gta gca gta gca gct gga gaa ttt ctc tac aaa aag ctc ttc agt cgt     1759
 Val Ala Val Ala Ala Gly Glu Phe Leu Tyr Lys Lys Leu Phe Ser Arg
 355                 360                 365                 370

 aga gat cca gag gag gat gga atg atg aaa aga aga gga aga caa ggt     1807
 Arg Asp Pro Glu Glu Asp Gly Met Met Lys Arg Arg Gly Arg Gln Gly
                 375                 380                 385

 cca aat gcc aac ctt gtt aag aca ttg gtt ttt ttc ttt cta gaa agt     1855
 Pro Asn Ala Asn Leu Val Lys Thr Leu Val Phe Phe Phe Leu Glu Ser
             390                 395                 400

 gag tta cat gag cat gca gca tac ctt gtg gat agc atg tgg gac tgt     1903
 Glu Leu His Glu His Ala Ala Tyr Leu Val Asp Ser Met Trp Asp Cys
         405                 410                 415

 gct act gag ctg ctg aaa gac tgg gaa tgt atg aat agc ttg tta ctg     1951
 Ala Thr Glu Leu Leu Lys Asp Trp Glu Cys Met Asn Ser Leu Leu Leu
     420                 425                 430

 gaa gag cca ctt agt gga gag gaa gca cta aca gat agg caa gag agt     1999
 Glu Glu Pro Leu Ser Gly Glu Glu Ala Leu Thr Asp Arg Gln Glu Ser
 435                 440                 445                 450

 gct ctg att gaa ata atg ctt tgt acc att aga caa gcg gct gaa tgt     2047
 Ala Leu Ile Glu Ile Met Leu Cys Thr Ile Arg Gln Ala Ala Glu Cys
                 455                 460                 465

 cat cct ccc gtg gga aga ggg aca gga aaa agg gtg ctt aca gca aag     2095
 His Pro Pro Val Gly Arg Gly Thr Gly Lys Arg Val Leu Thr Ala Lys
             470                 475                 480

 gag aag aag aca cag ttg gat gat agg aca aaa atc act gag ctt ttt     2143
 Glu Lys Lys Thr Gln Leu Asp Asp Arg Thr Lys Ile Thr Glu Leu Phe
         485                 490                 495

 gcc gtg gcc ctt cct cag tta tta gca aaa tac tct gta gat gca gaa     2191
 Ala Val Ala Leu Pro Gln Leu Leu Ala Lys Tyr Ser Val Asp Ala Glu
     500                 505                 510

 aag gtg act aac ttg ttg cag ttg cct cag tac ttt gat ttg gaa ata     2239
 Lys Val Thr Asn Leu Leu Gln Leu Pro Gln Tyr Phe Asp Leu Glu Ile
 515                 520                 525                 530

 tat acc act gga cga tta gaa aag cat ttg gat gcc tta ttg cga cag     2287
 Tyr Thr Thr Gly Arg Leu Glu Lys His Leu Asp Ala Leu Leu Arg Gln
                 535                 540                 545

 atc cgg aat att gta gag aag cac aca gat aca gat gtt ttg gaa gca     2335
 Ile Arg Asn Ile Val Glu Lys His Thr Asp Thr Asp Val Leu Glu Ala
             550                 555                 560

 tgt tct aaa act tac cat gca ctc tgt aat gaa gag ttc aca atc ttc     2383
 Cys Ser Lys Thr Tyr His Ala Leu Cys Asn Glu Glu Phe Thr Ile Phe
         565                 570                 575

 aac aga gta gat att tca aga agt caa ctg ata gat gaa ttg gca gat     2431
 Asn Arg Val Asp Ile Ser Arg Ser Gln Leu Ile Asp Glu Leu Ala Asp
     580                 585                 590

 aaa ttt aac cgg ctt ctt gaa gat ttt ctg caa gag ggt gaa gaa cct     2479
 Lys Phe Asn Arg Leu Leu Glu Asp Phe Leu Gln Glu Gly Glu Glu Pro
 595                 600                 605                 610

 gat gaa gat gat gca tat cag gta ttg tca aca ttg aag agg atc act     2527
 Asp Glu Asp Asp Ala Tyr Gln Val Leu Ser Thr Leu Lys Arg Ile Thr
                 615                 620                 625

 gct ttt cat aat gcc cat gac ctt tca aag agg gat tta ttt gct tgt     2575
 Ala Phe His Asn Ala His Asp Leu Ser Lys Arg Asp Leu Phe Ala Cys
             630                 635                 640

 aat tac aaa ctc ttg aaa act gga atc gaa aat gga gac atg cct gag     2623
 Asn Tyr Lys Leu Leu Lys Thr Gly Ile Glu Asn Gly Asp Met Pro Glu
         645                 650                 655

 cag att gtt att cac gca ctg cag tgt act cac tat gta atc ctt tgg     2671
 Gln Ile Val Ile His Ala Leu Gln Cys Thr His Tyr Val Ile Leu Trp
     660                 665                 670

 caa ctt gct aag ata act gaa agc agc tct aca aag gag gac ttg ctg     2719
 Gln Leu Ala Lys Ile Thr Glu Ser Ser Ser Thr Lys Glu Asp Leu Leu
 675                 680                 685                 690

 cgt tta aag aaa caa atg aga gta ttt tgt cag ata tgt caa cat tac     2767
 Arg Leu Lys Lys Gln Met Arg Val Phe Cys Gln Ile Cys Gln His Tyr
                 695                 700                 705

 ctg acc aac gtg aat act act gtt aag gaa cag gcc ttc act att ctg     2815
 Leu Thr Asn Val Asn Thr Thr Val Lys Glu Gln Ala Phe Thr Ile Leu
             710                 715                 720

 tgt gat att ttg atg atc ttc agc cat cag att atg tca gga ggg cgt     2863
 Cys Asp Ile Leu Met Ile Phe Ser His Gln Ile Met Ser Gly Gly Arg
         725                 730                 735

 gac atg tta gag cca tta gtg tat acc cct gat tct tca ttg cag tct     2911
 Asp Met Leu Glu Pro Leu Val Tyr Thr Pro Asp Ser Ser Leu Gln Ser
     740                 745                 750

 gag ttg ctc agc ttt att ttg gat cat gtc ttc att gaa cag gat gat     2959
 Glu Leu Leu Ser Phe Ile Leu Asp His Val Phe Ile Glu Gln Asp Asp
 755                 760                 765                 770

 gat aat aat agt gca gat ggt cag caa gag gat gaa gcc agt aaa att     3007
 Asp Asn Asn Ser Ala Asp Gly Gln Gln Glu Asp Glu Ala Ser Lys Ile
                 775                 780                 785

 gaa gct ctg cac aag aga aga aat tta ctt gca gca ttt tgt aag cta     3055
 Glu Ala Leu His Lys Arg Arg Asn Leu Leu Ala Ala Phe Cys Lys Leu
             790                 795                 800

 att gta tat act gtg gtg gag atg aat aca gct gca gat atc ttc aaa     3103
 Ile Val Tyr Thr Val Val Glu Met Asn Thr Ala Ala Asp Ile Phe Lys
         805                 810                 815

 cag tat atg aag tat tat aat gac tat gga gat atc atc aaa gaa aca     3151
 Gln Tyr Met Lys Tyr Tyr Asn Asp Tyr Gly Asp Ile Ile Lys Glu Thr
     820                 825                 830

 atg agt aaa aca agg cag ata gac aaa att cag tgt gct aag acc ctt     3199
 Met Ser Lys Thr Arg Gln Ile Asp Lys Ile Gln Cys Ala Lys Thr Leu
 835                 840                 845                 850

 att ctc agt ctg caa cag ctt ttt aat gaa atg ata caa gaa aat ggc     3247
 Ile Leu Ser Leu Gln Gln Leu Phe Asn Glu Met Ile Gln Glu Asn Gly
                 855                 860                 865

 tat aat ttt gat aga tca tcc tct aca ttt agt ggc ata aaa gaa ctt     3295
 Tyr Asn Phe Asp Arg Ser Ser Ser Thr Phe Ser Gly Ile Lys Glu Leu
             870                 875                 880

 gct cga cgt ttt gct tta act ttt gga ctt gat cag ttg aaa aca aga     3343
 Ala Arg Arg Phe Ala Leu Thr Phe Gly Leu Asp Gln Leu Lys Thr Arg
         885                 890                 895

 gaa gcc att gcc atg cta cac aaa gat ggc ata gaa ttt gct ttt aaa     3391
 Glu Ala Ile Ala Met Leu His Lys Asp Gly Ile Glu Phe Ala Phe Lys
     900                 905                 910

 gag cct aat ccg caa ggg gag agc cat cca cct tta aat ttg gca ttt     3439
 Glu Pro Asn Pro Gln Gly Glu Ser His Pro Pro Leu Asn Leu Ala Phe
 915                 920                 925                 930

 ctt gat att ctg agt gaa ttt tct tct aaa cta ctt cga caa gac aaa     3487
 Leu Asp Ile Leu Ser Glu Phe Ser Ser Lys Leu Leu Arg Gln Asp Lys
                 935                 940                 945

 aga aca gtg tat gtt tac ttg gaa aag ttc atg acc ttt cag atg tca     3535
 Arg Thr Val Tyr Val Tyr Leu Glu Lys Phe Met Thr Phe Gln Met Ser
             950                 955                 960

 ctc cga aga gag gat gtg tgg ctt cca ctg atg tct tac cga aat tct     3583
 Leu Arg Arg Glu Asp Val Trp Leu Pro Leu Met Ser Tyr Arg Asn Ser
         965                 970                 975

 ttg cta gct ggt ggt gat gat gac acc atg tca gtc att agt gga atc     3631
 Leu Leu Ala Gly Gly Asp Asp Asp Thr Met Ser Val Ile Ser Gly Ile
     980                 985                 990

 agc agc cgg ggg tca aca gta cgg agt aaa aaa tca aaa cca tct aca     3679
 Ser Ser Arg Gly Ser Thr Val Arg Ser Lys Lys Ser Lys Pro Ser Thr
 995                1000                1005                1010

 gga aaa cgg aaa gtg gtt gag ggc atg cag ctt tca ctc act gaa gaa     3727
 Gly Lys Arg Lys Val Val Glu Gly Met Gln Leu Ser Leu Thr Glu Glu
                1015                1020                1025

 agt agt agt agt gac agt atg tgg tta agc aga gaa caa aca ctg cac     3775
 Ser Ser Ser Ser Asp Ser Met Trp Leu Ser Arg Glu Gln Thr Leu His
            1030                1035                1040

 acc cct gtt atg atg cag aca cca caa ctc acc tcc act att atg aga     3823
 Thr Pro Val Met Met Gln Thr Pro Gln Leu Thr Ser Thr Ile Met Arg
        1045                1050                1055

 gag ccc aaa aga tta cgg cct gag gat agc ttc atg agt gtt tat cca     3871
 Glu Pro Lys Arg Leu Arg Pro Glu Asp Ser Phe Met Ser Val Tyr Pro
    1060                1065                1070

 atg cag act gaa cat cat caa aca cct ctt gat tat aat cgg cgt ggc     3919
 Met Gln Thr Glu His His Gln Thr Pro Leu Asp Tyr Asn Arg Arg Gly
1075                1080                1085                1090

 aca agc cta atg gaa gat gat gaa gag cca att gtg gaa gat gtt atg     3967
 Thr Ser Leu Met Glu Asp Asp Glu Glu Pro Ile Val Glu Asp Val Met
                1095                1100                1105

 atg tcc tca gaa ggg agg att gag gat ctt aat gag gga atg gat ttt     4015
 Met Ser Ser Glu Gly Arg Ile Glu Asp Leu Asn Glu Gly Met Asp Phe
            1110                1115                1120

 gac acc atg gat ata gat ttg cca cca tca aag aac aga cga gag aga     4063
 Asp Thr Met Asp Ile Asp Leu Pro Pro Ser Lys Asn Arg Arg Glu Arg
        1125                1130                1135

 aca gaa ctg aag cct gat ttc ttt gat cca gct tca att atg gat gaa     4111
 Thr Glu Leu Lys Pro Asp Phe Phe Asp Pro Ala Ser Ile Met Asp Glu
    1140                1145                1150

 tca gtt ctt gga gtg tca atg ttt taataccagt acacaattaa atctgtggtg    4165
 Ser Val Leu Gly Val Ser Met Phe 
1155                1160

 aagtcatttt ctaagtggaa gaggaaattt taaagtgtgg tagatacagt gaaattctgt   4225

 acagattttt ctctaaggag aatatgacat gcttatgctt accaagatca agtgcattga   4285

 ggggcagttt tgtttgcctg aataaacgta aaggacaagt aaacaatttg atgataagct   4345

 acagtttttc ttagaaagta aatattttat ttatgcgctg ttagttggct tttgaatcga   4405

 ttatttcatg ctttttttta aaaaaaaaaa aaaaa                              4440




      <210> 9
      <211> 596
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (22)..(420)

      <400> 9
 cgctggtctt cgctggacac c  atg aat cac act gtc caa acc ttc ttc tct      51
                          Met Asn His Thr Val Gln Thr Phe Phe Ser
                            1               5                  10

 cct gtc aac agt ggc cag ccc ccc aac tat gag atg ctc aag gag gag       99
 Pro Val Asn Ser Gly Gln Pro Pro Asn Tyr Glu Met Leu Lys Glu Glu
                  15                  20                  25

 cac gag gtg gct gtg ctg ggg gcg ccc cac aac cct gct ccc ccg acg      147
 His Glu Val Ala Val Leu Gly Ala Pro His Asn Pro Ala Pro Pro Thr
              30                  35                  40

 tcc acc gtg atc cac atc cgc agc gag acc tcc gtg ccc gac cat gtc      195
 Ser Thr Val Ile His Ile Arg Ser Glu Thr Ser Val Pro Asp His Val
          45                  50                  55

 gtc tgg tcc ctg ttc aac acc ctc ttc atg aac ccc tgc tgc ctg ggc      243
 Val Trp Ser Leu Phe Asn Thr Leu Phe Met Asn Pro Cys Cys Leu Gly
      60                  65                  70

 ttc ata gca ttc gcc tac tcc gtg aag tct agg gac agg aag atg gtt      291
 Phe Ile Ala Phe Ala Tyr Ser Val Lys Ser Arg Asp Arg Lys Met Val
  75                  80                  85                  90

 ggc gac gtg acc ggg gcc cag gcc tat gcc tcc acc gcc aag tgc ctg      339
 Gly Asp Val Thr Gly Ala Gln Ala Tyr Ala Ser Thr Ala Lys Cys Leu
                  95                 100                 105

 aac atc tgg gcc ctg att ctg ggc atc ctc atg acc att ctg ctc atc      387
 Asn Ile Trp Ala Leu Ile Leu Gly Ile Leu Met Thr Ile Leu Leu Ile
             110                 115                 120

 gtc atc cca gtg ctg atc ttc cag gcc tat gga tagatcag gaggcatcac      438
 Val Ile Pro Val Leu Ile Phe Gln Ala Tyr Gly 
         125                 130

 tgaggccagg agctctgccc atgacctgta tcccacgtac tccaacttcc attcctcgcc    498

 ctgcccccgg agccgagtcc tgtatcagcc ctttatcctc acacgctttt ctacaatggc    558

 attcaataaa gtgcacgtgt ttctggtcga cgcggccg                            596




      <210> 10
      <211> 3227
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1672)..(2802)

      <400> 10
 tgttggaagt tctggccagg gcaatcaggc aggagaagga aataaagggt attcaattag     60

 gaaaagagga agtcaaattg tccctgtttg cagatgacat gattgtatat ctagaaaacc    120

 ccattgtctc agcccaaaat ctccttaagc tgataagcaa cttcagcaaa gtctcaggat    180

 acaaaatcaa tgtgcaaaaa tcacagtcat tcttatacac caataacaga caaacaggga    240

 gccaaatcat gagtgaactc ccattcacaa ttgcttcaaa gagaataaaa tacctaggaa    300

 tccaacttac aagggatgtg aaggacctct tcaaggagaa ctacaaacca ctgctcaatg    360

 aaataaaaga ggatacaaac aaatggaaga acattccatg ctcatggata ggaagaatca    420

 atatcatgaa aatggccata ctacccaagg taatttatag attcaatgcc acccccatca    480

 agctaccaac gactttcttc acagaactgg aaaaaactac tttaaagttc atatggaatc    540

 aaaaaagagc ccgcatcgcc aagtcaatcc taagccaaaa gaacaaagca agaataaagc    600

 tggaggcatc actattcaaa ctatactaca aggctacagt aaccgaaaca gcatggtact    660

 ggtaccaaaa cagagatata gatcaatgga acagaacaga gccctcagaa ataatgccgc    720

 atatctacaa ctatctgatc tttgacaaac ctgagaaaaa caagcaatgg ggaaaggatt    780

 ccctatttaa taaatggtgc tgggaaaact ggctagccat atgtagaaag ctgaaactgg    840

 atcccttcct tacaccttat acaaaaatca attcaagatg gattaaagac ttaaatgtta    900

 gacctaaagc cataaaagtc ctagaagaaa acctaggcaa taccattcag gacataggca    960

 tgggcaagga cttcatgact aaaacaccaa aagcaatggc aacaaaagcc aaaattgaca   1020

 aatgggatat aattaaccta aagagcttct gcacagcaga agaaactacc atcagagtga   1080

 acaggcaacc tacagaatgg gagaaaaatt ttgcaatcta cccatctgac aaaggactaa   1140

 tatccagatt ctacaaagaa ctcaaacaaa tttacaagaa aaaaaaaacc atcaaaaagt   1200

 gggcaaagga tatgaacaga cacttctcaa acggagacat ttatgcagcc aacagacaca   1260

 tgaaaaaatg ctcatcatca ctggtcatca gagaaatgca aatcaaaatc acaatgagat   1320

 accatctcat accagttaga atggcaatca ttaaaaagtc aggaaacaac aggtgttgga   1380

 gaggatgtgg agaaatagga acacttttac actgttggtg ggactgtaaa ctagttcaac   1440

 cattgtggaa gacagtgtgg cgattcctca aggatctaga actagaaata ccatttgact   1500

 cagcaatccc attactgggt atatacccaa aagattataa atcatgctgc tataaagaca   1560

 catgtacaca gctacgcggc ggcggcggag cgcaggcctc gtgccgttac ggccatcacg   1620

 gcggccgcag tggcgtcctg gagccctcct cagtgctgaa gctgctgaaa g atg gca    1677
                                                          Met Ala
                                                            1

 gaa gaa gtg gtg gta gta gcc aaa ttt gat tat gtg gcc caa caa gaa     1725
 Glu Glu Val Val Val Val Ala Lys Phe Asp Tyr Val Ala Gln Gln Glu
           5                  10                  15

 caa gag ttg gac atc aag aag aat gag aga tta tgg ctt ctg gat gat     1773
 Gln Glu Leu Asp Ile Lys Lys Asn Glu Arg Leu Trp Leu Leu Asp Asp
      20                  25                  30

 tct aag tcc tgg tgg cga gtt cga aat tcc atg aat aaa aca ggt ttt     1821
 Ser Lys Ser Trp Trp Arg Val Arg Asn Ser Met Asn Lys Thr Gly Phe
  35                  40                  45                  50

 gtg cct tct aac tat gtg gaa agg aaa aac agt gct cgg aaa gca tct     1869
 Val Pro Ser Asn Tyr Val Glu Arg Lys Asn Ser Ala Arg Lys Ala Ser
                  55                  60                  65

 att gtg aaa aac cta aag gat acc tta ggc att gga aaa gtg aaa aga     1917
 Ile Val Lys Asn Leu Lys Asp Thr Leu Gly Ile Gly Lys Val Lys Arg
              70                  75                  80

 aaa cct agt gtg cca gat tct gca tct cct gct gat gat agt ttt gtt     1965
 Lys Pro Ser Val Pro Asp Ser Ala Ser Pro Ala Asp Asp Ser Phe Val
          85                  90                  95

 gac cca ggg gaa cgt ctc tat gac ctc aac atg ccc gct tat gtg aaa     2013
 Asp Pro Gly Glu Arg Leu Tyr Asp Leu Asn Met Pro Ala Tyr Val Lys
     100                 105                 110

 ttt aac tac atg gct gag aga gag gat gaa tta tca ttg ata aag ggg     2061
 Phe Asn Tyr Met Ala Glu Arg Glu Asp Glu Leu Ser Leu Ile Lys Gly
 115                 120                 125                 130

 aca aag gtg atc gtc atg gag aaa tgc agt gat ggg tgg tgg cgt ggt     2109
 Thr Lys Val Ile Val Met Glu Lys Cys Ser Asp Gly Trp Trp Arg Gly
                 135                 140                 145

 agc tac aat gga caa gtt gga tgg ttc cct tca aac tat gta act gaa     2157
 Ser Tyr Asn Gly Gln Val Gly Trp Phe Pro Ser Asn Tyr Val Thr Glu
             150                 155                 160

 gaa ggt gac agt cct ttg ggt gac cat gtg ggt tct ctg tca gag aaa     2205
 Glu Gly Asp Ser Pro Leu Gly Asp His Val Gly Ser Leu Ser Glu Lys
         165                 170                 175

 tta gca gca gtc gtc aat aac cta aat act ggg caa gtg ttg cat gtg     2253
 Leu Ala Ala Val Val Asn Asn Leu Asn Thr Gly Gln Val Leu His Val
     180                 185                 190

 gta cag gct ctt tac cca ttc agc tca tct aat gat gaa gaa ctt aat     2301
 Val Gln Ala Leu Tyr Pro Phe Ser Ser Ser Asn Asp Glu Glu Leu Asn
 195                 200                 205                 210

 ttc gag aaa gga gat gta atg gat gtt att gaa aaa cct gaa aat gac     2349
 Phe Glu Lys Gly Asp Val Met Asp Val Ile Glu Lys Pro Glu Asn Asp
                 215                 220                 225

 cca gag tgg tgg aaa tgc agg aag atc aat ggt atg gtt ggt cta gta     2397
 Pro Glu Trp Trp Lys Cys Arg Lys Ile Asn Gly Met Val Gly Leu Val
             230                 235                 240

 cca aaa aac tat gtt acc gtt atg cag aat aat cca tta act tca ggt     2445
 Pro Lys Asn Tyr Val Thr Val Met Gln Asn Asn Pro Leu Thr Ser Gly
         245                 250                 255

 ttg gaa cca tca cct cca cag tgt gat tac att agg cct tca ctc act     2493
 Leu Glu Pro Ser Pro Pro Gln Cys Asp Tyr Ile Arg Pro Ser Leu Thr
     260                 265                 270

 gga aag ttt gct ggc aat cct tgg tat tat ggc aaa gtc acc agg cat     2541
 Gly Lys Phe Ala Gly Asn Pro Trp Tyr Tyr Gly Lys Val Thr Arg His
 275                 280                 285                 290

 caa gca gaa atg gca tta aat gaa aga gga cat gaa ggg gat ttc ctc     2589
 Gln Ala Glu Met Ala Leu Asn Glu Arg Gly His Glu Gly Asp Phe Leu
                 295                 300                 305

 att cgt gat agt gaa tct tcg cca aat gat ttc tca gta tca cta aaa     2637
 Ile Arg Asp Ser Glu Ser Ser Pro Asn Asp Phe Ser Val Ser Leu Lys
             310                 315                 320

 gca caa ggg aaa aac aag cat ttt aaa gtc caa cta aaa gag act gtc     2685
 Ala Gln Gly Lys Asn Lys His Phe Lys Val Gln Leu Lys Glu Thr Val
         325                 330                 335

 tac tgc att ggg cag cgt aaa ttc agc acc atg gaa gaa ctt gta gaa     2733
 Tyr Cys Ile Gly Gln Arg Lys Phe Ser Thr Met Glu Glu Leu Val Glu
     340                 345                 350

 cat tac aaa aag gca cca att ttt aca agt gaa caa gga gaa aaa tta     2781
 His Tyr Lys Lys Ala Pro Ile Phe Thr Ser Glu Gln Gly Glu Lys Leu
 355                 360                 365                 370

 tat ctt gtc aag cat tta tca tg atactgctga ccagaagtga ctgctgtgta     2834
 Tyr Leu Val Lys His Leu Ser 
                 375

 gctgtaattt gtcatgtaat tgaattgaag actgagaaaa tgttgggtcc agtcgtgctt   2894

 gattggaaat tgttgtttct aaatctatat gagaattgac aataagtatt tttattataa   2954

 ctcagcccat acatatatac tatgtatgca gtgcatctgc atagaacagt tccttatcct   3014

 tggccttctg ttttattgtt tttttctttg ctgttttccc tttgcttcta atattacagt   3074

 tttgtatttt gtaaacaaaa atcaaataat gcatatcaga atctttatat ggaagaaatc   3134

 ctttattgcc tttcctttgt ttccttgtaa aggcaccctg ttctgttatg gtttttcatt   3194

 atataaaatt attatatcta taaaaaaaaa aaa                                3227




      <210> 11
      <211> 865
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (46)..(810)

      <400> 11
 tactactact aaattcgcgg ccggtacgac ggctgcggcg ggaag    atg gcg gag      54
                                                      Met Ala Glu
                                                        1

 ctg cgc gtg ctc gta gct gtc aag agg gtc atc gac tac gcc gtg aag      102
 Leu Arg Val Leu Val Ala Val Lys Arg Val Ile Asp Tyr Ala Val Lys
       5                  10                  15

 atc cga gtg aag cct gac agg acc ggt gtg gtc acg gat ggt gtg aag      150
 Ile Arg Val Lys Pro Asp Arg Thr Gly Val Val Thr Asp Gly Val Lys
  20                  25                  30                  35

 cac tcc atg aac ccc ttc tgt gag atc gcg gtg gag gag gct gtg cgg      198
 His Ser Met Asn Pro Phe Cys Glu Ile Ala Val Glu Glu Ala Val Arg
                  40                  45                  50

 ctc aag gag aag aag ctg gtg aag gag gtc atc gcc gtc agc tgt ggg      246
 Leu Lys Glu Lys Lys Leu Val Lys Glu Val Ile Ala Val Ser Cys Gly
              55                  60                  65

 cct gca cag tgc cag gag acg att cgt acc gcc ctg gcc atg ggt gca      294
 Pro Ala Gln Cys Gln Glu Thr Ile Arg Thr Ala Leu Ala Met Gly Ala
          70                  75                  80

 gac cga ggt atc cac gtg gag gtg ccc cca gca gaa gca gaa cgc ttg      342
 Asp Arg Gly Ile His Val Glu Val Pro Pro Ala Glu Ala Glu Arg Leu
      85                  90                  95

 ggt ccc ctg cag gtg gct cgg gtc ctg gcc aag ctg gca gag aag gag      390
 Gly Pro Leu Gln Val Ala Arg Val Leu Ala Lys Leu Ala Glu Lys Glu
 100                 105                 110                 115

 aag gtg gac ctg gtg ctg ctg ggc aaa cag gcc atc gat gat gac tgt      438
 Lys Val Asp Leu Val Leu Leu Gly Lys Gln Ala Ile Asp Asp Asp Cys
                 120                 125                 130

 aac cag aca ggg cag atg aca gct gga ttt ctt gac tgg cca cag ggc      486
 Asn Gln Thr Gly Gln Met Thr Ala Gly Phe Leu Asp Trp Pro Gln Gly
             135                 140                 145

 aca ttc gcc tcc cag gtg atg ctg gag ggg gac aag ttg aaa gtg gag      534
 Thr Phe Ala Ser Gln Val Met Leu Glu Gly Asp Lys Leu Lys Val Glu
         150                 155                 160

 cgg gag atc gat ggg ggc ctg gag acc ctg cgc ctg aag ctg cca gct      582
 Arg Glu Ile Asp Gly Gly Leu Glu Thr Leu Arg Leu Lys Leu Pro Ala
     165                 170                 175

 gtg gtg aca gct gac ctg agg ctc aac gag ccc cgc tac gcc acg ctg      630
 Val Val Thr Ala Asp Leu Arg Leu Asn Glu Pro Arg Tyr Ala Thr Leu
 180                 185                 190                 195

 ccc aac atc atg aaa gcc aag aag aag aag atc gag gtg atc aag cct      678
 Pro Asn Ile Met Lys Ala Lys Lys Lys Lys Ile Glu Val Ile Lys Pro
                 200                 205                 210

 ggg gac ctg ggt gtg gac ctg acc tcc aag ctc tct gtg atc agt gtg      726
 Gly Asp Leu Gly Val Asp Leu Thr Ser Lys Leu Ser Val Ile Ser Val
             215                 220                 225

 gag gac ccg ccc cag cgc acg gcc ggc gtc aag gtg gag acc act gag      774
 Glu Asp Pro Pro Gln Arg Thr Ala Gly Val Lys Val Glu Thr Thr Glu
         230                 235                 240

 gac ctg gtg gcc aag ctg aag gag att ggg cgg att tgag cccctcccag      824
 Asp Leu Val Ala Lys Leu Lys Glu Ile Gly Arg Ile 
     245                 250                 255

 agatggcaat aaaactgact ctcaacatca aaaaaaaaaa a                        865




      <210> 12
      <211> 1989
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (330)..(1442)

      <400> 12
 gtccctgggc cggggctcgc gctggccggc tgcagcgcgc agggtgccaa gccctcccct     60

 acgaagtctg ttttgtctca ggctgggctg agtcacatag aatagataga tagttgattt    120

 agcacatgtc ctccagatca tattatccgc ctacaaatat agcctgttag cgcacaggca    180

 cgggaggctt cttccggctc ggccgtgctg ctcagcgggt gtaaacagcc tctgcggtgt    240

 aaacagcctc tgcggtgtaa acagccgcgg cgggcaggcc aggactgtca gtgcccgccc    300

 ctcggggcag gtaatttcat gctcccaaa  atg gga cat aaa gtg gtt gtc ttc     353
                                  Met Gly His Lys Val Val Val Phe
                                    1               5

 gac att tct gtc atc aga gcc ttg tgg gaa act cgt gtc aag aag cac      401
 Asp Ile Ser Val Ile Arg Ala Leu Trp Glu Thr Arg Val Lys Lys His
      10                  15                  20

 aaa gct tgg cag aag aag gag gtg gaa agg ctt gag aag agc gcc ttg      449
 Lys Ala Trp Gln Lys Lys Glu Val Glu Arg Leu Glu Lys Ser Ala Leu
  25                  30                  35                  40

 gag aag ata aag gag gag tgg aac ttt gtg gcc gaa tgc agg agg aag      497
 Glu Lys Ile Lys Glu Glu Trp Asn Phe Val Ala Glu Cys Arg Arg Lys
                  45                  50                  55

 ggc atc ccc cag gct gta tac tgc aag aat ggc ttc ata gac acc agc      545
 Gly Ile Pro Gln Ala Val Tyr Cys Lys Asn Gly Phe Ile Asp Thr Ser
              60                  65                  70

 gtg cgg ctt ctg gac aag att gaa agg aac act ctc aca agg cag agt      593
 Val Arg Leu Leu Asp Lys Ile Glu Arg Asn Thr Leu Thr Arg Gln Ser
          75                  80                  85

 tca ctt ccc aag gac aga ggc aaa cgg agc agt gcg ttt gtg ttt gaa      641
 Ser Leu Pro Lys Asp Arg Gly Lys Arg Ser Ser Ala Phe Val Phe Glu
      90                  95                 100

 ctt tct ggg gag cac tgg acg gag ctc cca gat tca ttg aag gag cag      689
 Leu Ser Gly Glu His Trp Thr Glu Leu Pro Asp Ser Leu Lys Glu Gln
 105                 110                 115                 120

 aca cac ctg aga gaa tgg tac ata agc aat acc ttg att caa atc att      737
 Thr His Leu Arg Glu Trp Tyr Ile Ser Asn Thr Leu Ile Gln Ile Ile
                 125                 130                 135

 cct aca tat att cag tta ttt caa gcg atg aga att ctg gat ctg cca      785
 Pro Thr Tyr Ile Gln Leu Phe Gln Ala Met Arg Ile Leu Asp Leu Pro
             140                 145                 150

 aaa aac caa atc tca cat ctt cca gca gaa atc ggt tgt ttg aag aac      833
 Lys Asn Gln Ile Ser His Leu Pro Ala Glu Ile Gly Cys Leu Lys Asn
         155                 160                 165

 ctg aaa gaa ctc aat gtg ggt ttc aac tat ctg aag agc att cct cca      881
 Leu Lys Glu Leu Asn Val Gly Phe Asn Tyr Leu Lys Ser Ile Pro Pro
     170                 175                 180

 gaa ttg gga gat tgt gaa aat cta gag aga ctg gat tgt tct gga aat      929
 Glu Leu Gly Asp Cys Glu Asn Leu Glu Arg Leu Asp Cys Ser Gly Asn
 185                 190                 195                 200

 cta gaa tta atg gag ctg ccc ttt gaa tta agt aat ttg aag caa gtt      977
 Leu Glu Leu Met Glu Leu Pro Phe Glu Leu Ser Asn Leu Lys Gln Val
                 205                 210                 215

 aca ttt gta gat atc tca gca aac aag ttt tcc agt gtc cca atc tgt     1025
 Thr Phe Val Asp Ile Ser Ala Asn Lys Phe Ser Ser Val Pro Ile Cys
             220                 225                 230

 gtc ctg cgg atg tcg aat ttg cag tgg ttg gat atc agc agc aat aac     1073
 Val Leu Arg Met Ser Asn Leu Gln Trp Leu Asp Ile Ser Ser Asn Asn
         235                 240                 245

 ctg acc gac ctg ccg caa gat ata gac agg cta gag gag ctg cag agc     1121
 Leu Thr Asp Leu Pro Gln Asp Ile Asp Arg Leu Glu Glu Leu Gln Ser
     250                 255                 260

 ttt ctc ttg tat aaa aac aag ttg acc tac ctt ccc tat tcc atg ctg     1169
 Phe Leu Leu Tyr Lys Asn Lys Leu Thr Tyr Leu Pro Tyr Ser Met Leu
 265                 270                 275                 280

 aac ctg aag aag ctc act ctg tta gtc gtc agt ggg gac cat ttg gtg     1217
 Asn Leu Lys Lys Leu Thr Leu Leu Val Val Ser Gly Asp His Leu Val
                 285                 290                 295

 gag ctc cca act gcc ctt tgt gac tca tcc aca cct tta aaa ttt gta     1265
 Glu Leu Pro Thr Ala Leu Cys Asp Ser Ser Thr Pro Leu Lys Phe Val
             300                 305                 310

 agc ctt atg gac aat cct att gat aat gcc caa tgt gaa gat ggc aat     1313
 Ser Leu Met Asp Asn Pro Ile Asp Asn Ala Gln Cys Glu Asp Gly Asn
         315                 320                 325

 gaa ata atg gaa agt gaa cgg gat cgc caa cat ttt gat aaa gaa gtt     1361
 Glu Ile Met Glu Ser Glu Arg Asp Arg Gln His Phe Asp Lys Glu Val
     330                 335                 340

 atg aaa gcc tat att gaa gac ctt aaa gaa aga gaa tct gtt ccc agc     1409
 Met Lys Ala Tyr Ile Glu Asp Leu Lys Glu Arg Glu Ser Val Pro Ser
 345                 350                 355                 360

 tat acc acc aaa gtg tct ttt agc ctt caa ctt tgatatcc atcagaagac     1460
 Tyr Thr Thr Lys Val Ser Phe Ser Leu Gln Leu 
                 365                 370

 tgcaaatctc actattctct ggagctatat ataaatcttt gttatgatca tgtcatatag   1520

 gaagaatggc ttgtgcttaa ggacaaagtc tagaaaccac tatcatagtt gctaaaaaaa   1580

 atggttttca aatgtcaaat acatgagtat ctccctccat ggactggaga attgaaaaat   1640

 tggtttgtat attgatattt ccaggttcat ttgcatatac ttttttccaa ataatgcaca   1700

 tttaatatgt tttaaaatgt cttattttta agaattataa ctaaaagacc aaatactgaa   1760

 gttaagtgca ttgttttcag gaatcaaaag ataaaggggc cgggtgtggt ggctcacacc   1820

 tgtaatccca gcactttggg aggccgaagt gggtggatca cctgaggtcc ggagttcgag   1880

 gctggtttgg ccagcatggc gaaaccccat ctctactaaa aatacaaaaa attagctggg   1940

 catggtggca gttgcctgta atcctagcta ctcaggaggc tgaggcagg               1989




      <210> 13
      <211> 549
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (156)..(503)

      <400> 13
 cacgcgtccg gcctggttct aggaataatg ggggaagtat gtaggagttg aagattagtc     60

 cgccgtagtc ggtgtactcg taggttcagt accattggtg gccaattgat ttgatggtaa    120

 gggagggatc gttgacctcg tctgttatgt aaagg   atg cgt agg gat gat agc     173
                                          Met Arg Arg Asp Asp Ser
                                            1               5

 gct cac gca agc atg gtt aac gtc cct aaa acc cgc cgg act ttc tgt      221
 Ala His Ala Ser Met Val Asn Val Pro Lys Thr Arg Arg Thr Phe Cys
              10                  15                  20

 aag aag tgt ggc aag cac caa ccc cat aaa gtg aca cag tac aag aag      269
 Lys Lys Cys Gly Lys His Gln Pro His Lys Val Thr Gln Tyr Lys Lys
          25                  30                  35

 ggc aag gat tct ctg tac gcc cag gga aag cgg cgt tat gac agg aag      317
 Gly Lys Asp Ser Leu Tyr Ala Gln Gly Lys Arg Arg Tyr Asp Arg Lys
      40                  45                  50

 cag agt ggc tat ggt ggg caa act aag ccg att ttc cgg aaa aag gct      365
 Gln Ser Gly Tyr Gly Gly Gln Thr Lys Pro Ile Phe Arg Lys Lys Ala
  55                  60                  65                  70

 aaa act aca aag aag att gtg cta agg ctt gag tgc gtt gag ccc aac      413
 Lys Thr Thr Lys Lys Ile Val Leu Arg Leu Glu Cys Val Glu Pro Asn
                  75                  80                  85

 tgc aga tct aag aga atg ctg gct att aaa aga tgc aag cat ttt gaa      461
 Cys Arg Ser Lys Arg Met Leu Ala Ile Lys Arg Cys Lys His Phe Glu
              90                  95                 100

 ctg gga gga gat aag aag aga aag ggc caa gtg atc cag ttc taagtgt      510
 Leu Gly Gly Asp Lys Lys Arg Lys Gly Gln Val Ile Gln Phe 
         105                 110                 115

 catcttttat tatgaagaca ataaaatctt gagtttatg                           549




      <210> 14
      <211> 1383
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1158)

      <400> 14
  atg gag ctg aaa gcc aag gct cga gaa cta cgt gaa gaa tgc aga agc      48
  Met Glu Leu Lys Ala Lys Ala Arg Glu Leu Arg Glu Glu Cys Arg Ser
    1               5                  10                  15

 ctc agg agc cga tgc gat caa ctg gaa gaa agg gta tca gtg atg gaa       96
 Leu Arg Ser Arg Cys Asp Gln Leu Glu Glu Arg Val Ser Val Met Glu
              20                  25                  30

 aat gaa atg aat gaa atg aag cga gaa ggg aag ttt aga gaa aaa aga      144
 Asn Glu Met Asn Glu Met Lys Arg Glu Gly Lys Phe Arg Glu Lys Arg
          35                  40                  45

 ata aaa aga aac gaa caa agc ctt caa gaa ata tgg gac tat gtg aaa      192
 Ile Lys Arg Asn Glu Gln Ser Leu Gln Glu Ile Trp Asp Tyr Val Lys
      50                  55                  60

 aga cca aat cta cat ctg att ggt gta cct gaa agt gac ggg gag aat      240
 Arg Pro Asn Leu His Leu Ile Gly Val Pro Glu Ser Asp Gly Glu Asn
  65                  70                  75                  80

 gga acc aag ttg gaa aac act ctg cag gat att atc cag gag aac ttc      288
 Gly Thr Lys Leu Glu Asn Thr Leu Gln Asp Ile Ile Gln Glu Asn Phe
                  85                  90                  95

 ccc aat cta gca agg cag gcc aac att cag att cag gaa ata cag aga      336
 Pro Asn Leu Ala Arg Gln Ala Asn Ile Gln Ile Gln Glu Ile Gln Arg
             100                 105                 110

 acg cca caa aga tac tcc tcg aga aga gca act cca aga cac ata att      384
 Thr Pro Gln Arg Tyr Ser Ser Arg Arg Ala Thr Pro Arg His Ile Ile
         115                 120                 125

 gtc aga atc acc aaa gtg gaa atg aag gaa aaa atg tta agg gca gcc      432
 Val Arg Ile Thr Lys Val Glu Met Lys Glu Lys Met Leu Arg Ala Ala
     130                 135                 140

 aga gag aaa ggt cgg gtt ccc cac aaa ggg aag ccc atc aga cta aca      480
 Arg Glu Lys Gly Arg Val Pro His Lys Gly Lys Pro Ile Arg Leu Thr
 145                 150                 155                 160

 gcg gat ctc tcg tca gaa act cta caa gcc aga aga gag tgg ggg cca      528
 Ala Asp Leu Ser Ser Glu Thr Leu Gln Ala Arg Arg Glu Trp Gly Pro
                 165                 170                 175

 ata ttc aac att ctt aaa aga att ttc agc ttt cca cag cgc ggg gga      576
 Ile Phe Asn Ile Leu Lys Arg Ile Phe Ser Phe Pro Gln Arg Gly Gly
             180                 185                 190

 acg gga ggc cgc agg atg gtc aag ctg acg gcg gag ctg atc gag cag      624
 Thr Gly Gly Arg Arg Met Val Lys Leu Thr Ala Glu Leu Ile Glu Gln
         195                 200                 205

 gcg gcg cag tac acc agc gcg gtg cgc gac cgg gag ctg gac ctc cgg      672
 Ala Ala Gln Tyr Thr Ser Ala Val Arg Asp Arg Glu Leu Asp Leu Arg
     210                 215                 220

 ggg tat aaa att ccc gtc att gaa aat cta ggt gct acg tta gac cag      720
 Gly Tyr Lys Ile Pro Val Ile Glu Asn Leu Gly Ala Thr Leu Asp Gln
 225                 230                 235                 240

 ttt gat gct att gat ttt tct gac aat gag atc agg aaa ctg gat ggt      768
 Phe Asp Ala Ile Asp Phe Ser Asp Asn Glu Ile Arg Lys Leu Asp Gly
                 245                 250                 255

 ttt cct ttg ttg aga aga ctg aaa acg ttg tta gtg aac aaa aca gaa      816
 Phe Pro Leu Leu Arg Arg Leu Lys Thr Leu Leu Val Asn Lys Thr Glu
             260                 265                 270

 tat gcc agt act gga ttt cca gaa agt gaa act aaa gag cgt cag gaa      864
 Tyr Ala Ser Thr Gly Phe Pro Glu Ser Glu Thr Lys Glu Arg Gln Glu
         275                 280                 285

 gca gag aaa atg ttc aag ggc aaa cgg ggt gca cag ctt gca aag gat      912
 Ala Glu Lys Met Phe Lys Gly Lys Arg Gly Ala Gln Leu Ala Lys Asp
     290                 295                 300

 att gcc agg aga agc aaa act ttt aat cca ggt gct ggt ttg cca act      960
 Ile Ala Arg Arg Ser Lys Thr Phe Asn Pro Gly Ala Gly Leu Pro Thr
 305                 310                 315                 320

 gac aaa aag aaa ggt ggg cca tct cca ggg gat gta gaa gca atc aag     1008
 Asp Lys Lys Lys Gly Gly Pro Ser Pro Gly Asp Val Glu Ala Ile Lys
                 325                 330                 335

 aat gcc ata gca aat gct tca act ctg gct gaa gtg gag agg ctg aag     1056
 Asn Ala Ile Ala Asn Ala Ser Thr Leu Ala Glu Val Glu Arg Leu Lys
             340                 345                 350

 ggg ttg ctg cag tct ggt cag atc cct ggc aga gaa cgc aga tca ggg     1104
 Gly Leu Leu Gln Ser Gly Gln Ile Pro Gly Arg Glu Arg Arg Ser Gly
         355                 360                 365

 ccc act gat gat ggt gaa gaa gag atg gaa gaa gac aca gtc aca aac     1152
 Pro Thr Asp Asp Gly Glu Glu Glu Met Glu Glu Asp Thr Val Thr Asn
     370                 375                 380

 ggg tcc tgagcagtga ggcagatgta taataatagg ccctcttgga acaagtcttg      1208
 Gly Ser 
 385

 cttttcgaac atggtataat agccttgttt gtgttagcaa agtggaatct atcagcattg   1268

 ttgaaatgct taagactgct gctgataatt ttgtaatata agttttgaaa tctaaatgtc   1328

 aattttctac aaattataaa aataaactcc actcactatg ctaccaaaaa aaaaa        1383




      <210> 15
      <211> 5933
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3717)

      <400> 15
  atg gcg gcc gcc ttc ggc cac ggc gga gga ctc gct ttc cca ggg gcc      48
  Met Ala Ala Ala Phe Gly His Gly Gly Gly Leu Ala Phe Pro Gly Ala
    1               5                  10                  15

 ccc gcg gtc gca ggg gca acg agc ccg gcc ggc cct cgc gag cgg agg       96
 Pro Ala Val Ala Gly Ala Thr Ser Pro Ala Gly Pro Arg Glu Arg Arg
              20                  25                  30

 cgg ggc cgg ggc cgg aag tca cgt gct gtg aca gta gct ggg gtg agg      144
 Arg Gly Arg Gly Arg Lys Ser Arg Ala Val Thr Val Ala Gly Val Arg
          35                  40                  45

 ccg tcg tcg ccg cac ggg ctg gtt ggg gct gtg tct gtg gga ggc gcc      192
 Pro Ser Ser Pro His Gly Leu Val Gly Ala Val Ser Val Gly Gly Ala
      50                  55                  60

 ggg gtg atg gcg gtg gag act ctg tcc ccg gac tgg gag ttt gac cgc      240
 Gly Val Met Ala Val Glu Thr Leu Ser Pro Asp Trp Glu Phe Asp Arg
  65                  70                  75                  80

 gtt gac gac ggc tcg cag aaa att cat gcc gaa gtc caa ctt aag aat      288
 Val Asp Asp Gly Ser Gln Lys Ile His Ala Glu Val Gln Leu Lys Asn
                  85                  90                  95

 tat ggg aaa ttt ctt gag gag tat acc tct caa ctg aga aga att gag      336
 Tyr Gly Lys Phe Leu Glu Glu Tyr Thr Ser Gln Leu Arg Arg Ile Glu
             100                 105                 110

 gac gct ctg gat gac tca att gga gat gtt tgg gat ttc aat ctt gat      384
 Asp Ala Leu Asp Asp Ser Ile Gly Asp Val Trp Asp Phe Asn Leu Asp
         115                 120                 125

 cct ata gca tta aag ctt ttg cct tat gaa cag tcc tct ctt ttg gaa      432
 Pro Ile Ala Leu Lys Leu Leu Pro Tyr Glu Gln Ser Ser Leu Leu Glu
     130                 135                 140

 ctc ata aag act gaa aac aag gtc tta aac aaa gtc atc act gtt tat      480
 Leu Ile Lys Thr Glu Asn Lys Val Leu Asn Lys Val Ile Thr Val Tyr
 145                 150                 155                 160

 gct gca ctt tgt tgt gaa atc aag aaa tta aaa tat gag gct gaa act      528
 Ala Ala Leu Cys Cys Glu Ile Lys Lys Leu Lys Tyr Glu Ala Glu Thr
                 165                 170                 175

 aaa ttt tac aat ggt ctc ttg ttt tat gga gaa gga gct aca gat gcc      576
 Lys Phe Tyr Asn Gly Leu Leu Phe Tyr Gly Glu Gly Ala Thr Asp Ala
             180                 185                 190

 agc atg gtg gaa ggt gat tgc caa att caa atg ggg aga ttt att tca      624
 Ser Met Val Glu Gly Asp Cys Gln Ile Gln Met Gly Arg Phe Ile Ser
         195                 200                 205

 ttc tta cag gaa ctg tct tgc ttt gtt acg agg tgc tat gaa gtg gtg      672
 Phe Leu Gln Glu Leu Ser Cys Phe Val Thr Arg Cys Tyr Glu Val Val
     210                 215                 220

 atg aac gta gtc cac cag ttg gct gcc ctc tat atc agt aac aag att      720
 Met Asn Val Val His Gln Leu Ala Ala Leu Tyr Ile Ser Asn Lys Ile
 225                 230                 235                 240

 gca ccc aaa att ata gag aca act gga gtt cat ttt cag act atg tat      768
 Ala Pro Lys Ile Ile Glu Thr Thr Gly Val His Phe Gln Thr Met Tyr
                 245                 250                 255

 gag cac ttg gga gaa ctg cta aca gtt ttg ctc acc ctg gat gaa att      816
 Glu His Leu Gly Glu Leu Leu Thr Val Leu Leu Thr Leu Asp Glu Ile
             260                 265                 270

 att gat aat cat atc aca ctg aaa gac cac tgg act atg tac aaa agg      864
 Ile Asp Asn His Ile Thr Leu Lys Asp His Trp Thr Met Tyr Lys Arg
         275                 280                 285

 tta ctg aaa tct gtc cat cac aat cct tca aaa ttt gga att cag gaa      912
 Leu Leu Lys Ser Val His His Asn Pro Ser Lys Phe Gly Ile Gln Glu
     290                 295                 300

 gaa aaa tta aag cca ttt gaa aag ttc ttg ctg aag cta gaa ggg caa      960
 Glu Lys Leu Lys Pro Phe Glu Lys Phe Leu Leu Lys Leu Glu Gly Gln
 305                 310                 315                 320

 tta ctg gat gga atg ata ttc cag gcc tgt ata gaa caa caa ttt gat     1008
 Leu Leu Asp Gly Met Ile Phe Gln Ala Cys Ile Glu Gln Gln Phe Asp
                 325                 330                 335

 tct ctc aat gga gga gta tct gtg tca aaa aat agt act ttt gct gag     1056
 Ser Leu Asn Gly Gly Val Ser Val Ser Lys Asn Ser Thr Phe Ala Glu
             340                 345                 350

 gaa ttt gca cat agt att cgg tca att ttt gca aat gta gaa gcc aaa     1104
 Glu Phe Ala His Ser Ile Arg Ser Ile Phe Ala Asn Val Glu Ala Lys
         355                 360                 365

 ctt gga gaa cct tct gaa att gac cag aga gac aag tat gtt gga att     1152
 Leu Gly Glu Pro Ser Glu Ile Asp Gln Arg Asp Lys Tyr Val Gly Ile
     370                 375                 380

 tgt gga ctc ttt gta ttg cac ttt cag att ttt cga act att gat aaa     1200
 Cys Gly Leu Phe Val Leu His Phe Gln Ile Phe Arg Thr Ile Asp Lys
 385                 390                 395                 400

 aag ttt tat aag tct tta ttg gac att tgt aag aag gta cca gcc atc     1248
 Lys Phe Tyr Lys Ser Leu Leu Asp Ile Cys Lys Lys Val Pro Ala Ile
                 405                 410                 415

 act cta act gct aat att att tgg ttt cct gat aat ttt ctg atc cag     1296
 Thr Leu Thr Ala Asn Ile Ile Trp Phe Pro Asp Asn Phe Leu Ile Gln
             420                 425                 430

 aaa ata cca gca gct gcc aaa ctg cta gac aga aaa agt ctt caa gcc     1344
 Lys Ile Pro Ala Ala Ala Lys Leu Leu Asp Arg Lys Ser Leu Gln Ala
         435                 440                 445

 att aaa ata cac agg gat act ttt cta caa cag aaa gct caa tca ctt     1392
 Ile Lys Ile His Arg Asp Thr Phe Leu Gln Gln Lys Ala Gln Ser Leu
     450                 455                 460

 acc aaa gat gta cag tct tac tac gtc ttt gtg agc tca tgg atg atg     1440
 Thr Lys Asp Val Gln Ser Tyr Tyr Val Phe Val Ser Ser Trp Met Met
 465                 470                 475                 480

 aaa atg gaa tct att ttg tct aaa gag cag aga atg gat aaa ttt gct     1488
 Lys Met Glu Ser Ile Leu Ser Lys Glu Gln Arg Met Asp Lys Phe Ala
                 485                 490                 495

 gaa gat ctc acc aat aga tgt aat gtt ttt ata cag ggc ttc ttg tat     1536
 Glu Asp Leu Thr Asn Arg Cys Asn Val Phe Ile Gln Gly Phe Leu Tyr
             500                 505                 510

 gca tat agt att agt acc att att aaa acc aca atg aat ctc tac atg     1584
 Ala Tyr Ser Ile Ser Thr Ile Ile Lys Thr Thr Met Asn Leu Tyr Met
         515                 520                 525

 tcc atg caa aag cca atg acc aaa acc tca gtt aag gca ttg tgc agg     1632
 Ser Met Gln Lys Pro Met Thr Lys Thr Ser Val Lys Ala Leu Cys Arg
     530                 535                 540

 ctt gtt gaa ctt ctc aag gca ata gag cat atg ttc tac agg aga agc     1680
 Leu Val Glu Leu Leu Lys Ala Ile Glu His Met Phe Tyr Arg Arg Ser
 545                 550                 555                 560

 atg gtt gtg gct gat tca gtt tca cat ata aca cag cac ctt caa cat     1728
 Met Val Val Ala Asp Ser Val Ser His Ile Thr Gln His Leu Gln His
                 565                 570                 575

 cag gct ctt cat tct att tct gtg gcc aag aaa aga gtg att tct gac     1776
 Gln Ala Leu His Ser Ile Ser Val Ala Lys Lys Arg Val Ile Ser Asp
             580                 585                 590

 aaa aaa tac agc gaa cag cgt ctt gat gtg ctc tct gct cta gtt ttg     1824
 Lys Lys Tyr Ser Glu Gln Arg Leu Asp Val Leu Ser Ala Leu Val Leu
         595                 600                 605

 gct gaa aac act cta aat gga cca agc aca aag caa cgg cga ctt att     1872
 Ala Glu Asn Thr Leu Asn Gly Pro Ser Thr Lys Gln Arg Arg Leu Ile
     610                 615                 620

 gtt tct ttg gca cta agt gtt ggc aca caa atg aaa aca ttt aaa gat     1920
 Val Ser Leu Ala Leu Ser Val Gly Thr Gln Met Lys Thr Phe Lys Asp
 625                 630                 635                 640

 gaa gaa ctc ttt cca ctt caa gta gtc atg aaa aaa ctg gat ctt att     1968
 Glu Glu Leu Phe Pro Leu Gln Val Val Met Lys Lys Leu Asp Leu Ile
                 645                 650                 655

 agt gaa ctt aga gaa cga gtc caa aca caa tgt gac tgt tgt ttt tta     2016
 Ser Glu Leu Arg Glu Arg Val Gln Thr Gln Cys Asp Cys Cys Phe Leu
             660                 665                 670

 tac tgg cat cga gct gtc ttc cca att tat tta gat gat gta tat gaa     2064
 Tyr Trp His Arg Ala Val Phe Pro Ile Tyr Leu Asp Asp Val Tyr Glu
         675                 680                 685

 aat gct gtt gat gca gcc aga tta cat tac atg ttc agt gct ttg cgc     2112
 Asn Ala Val Asp Ala Ala Arg Leu His Tyr Met Phe Ser Ala Leu Arg
     690                 695                 700

 gac tgt gta cct gct atg atg cat gca agg cat tta gag tcc tat gag     2160
 Asp Cys Val Pro Ala Met Met His Ala Arg His Leu Glu Ser Tyr Glu
 705                 710                 715                 720

 ata ctt ctg gat tgc tat gac aag gaa att atg gaa att tta aat gag     2208
 Ile Leu Leu Asp Cys Tyr Asp Lys Glu Ile Met Glu Ile Leu Asn Glu
                 725                 730                 735

 cat ttg ctg gac aaa tta tgc aaa gaa ata gag aaa gat ctg cga ctt     2256
 His Leu Leu Asp Lys Leu Cys Lys Glu Ile Glu Lys Asp Leu Arg Leu
             740                 745                 750

 tct gtg cat act cat tta aag ctg gat gac cga aac cct ttc aaa gtt     2304
 Ser Val His Thr His Leu Lys Leu Asp Asp Arg Asn Pro Phe Lys Val
         755                 760                 765

 ggc atg aaa gac ctg gct ctt ttt ttc tct ctg aat cca att cgg ttt     2352
 Gly Met Lys Asp Leu Ala Leu Phe Phe Ser Leu Asn Pro Ile Arg Phe
     770                 775                 780

 ttc aat cgt ttc att gac att cgg gct tac gta act cac tac cta gac     2400
 Phe Asn Arg Phe Ile Asp Ile Arg Ala Tyr Val Thr His Tyr Leu Asp
 785                 790                 795                 800

 aag act ttc tac aat cta aca act gta gcc ctt cat gac tgg gcc act     2448
 Lys Thr Phe Tyr Asn Leu Thr Thr Val Ala Leu His Asp Trp Ala Thr
                 805                 810                 815

 tat agt gag atg aga aac tta gct act cag cgt tat gga ctg gtt atg     2496
 Tyr Ser Glu Met Arg Asn Leu Ala Thr Gln Arg Tyr Gly Leu Val Met
             820                 825                 830

 aca gag gca cat ctt ccc agt cag act ttg gaa cag ggc ctt gat gtt     2544
 Thr Glu Ala His Leu Pro Ser Gln Thr Leu Glu Gln Gly Leu Asp Val
         835                 840                 845

 tta gaa att atg aga aac att cat ata ttt gtg tcc cga tac ctc tat     2592
 Leu Glu Ile Met Arg Asn Ile His Ile Phe Val Ser Arg Tyr Leu Tyr
     850                 855                 860

 aat ctc aac aat cag att ttt att gaa cga aca agc aat aac aag cat     2640
 Asn Leu Asn Asn Gln Ile Phe Ile Glu Arg Thr Ser Asn Asn Lys His
 865                 870                 875                 880

 ttg aat act att aat att cgg cat att gct aat tca att cga aca cat     2688
 Leu Asn Thr Ile Asn Ile Arg His Ile Ala Asn Ser Ile Arg Thr His
                 885                 890                 895

 ggc acg gga att atg aat aca act gtt aat ttc acc tac cag ttt ttg     2736
 Gly Thr Gly Ile Met Asn Thr Thr Val Asn Phe Thr Tyr Gln Phe Leu
             900                 905                 910

 aaa aag aag ttc tat ata ttt agc caa ttt atg tat gat gaa cac atc     2784
 Lys Lys Lys Phe Tyr Ile Phe Ser Gln Phe Met Tyr Asp Glu His Ile
         915                 920                 925

 aaa tcc aga ttg att aaa gat att cga ttt ttc agg gaa att aag gac     2832
 Lys Ser Arg Leu Ile Lys Asp Ile Arg Phe Phe Arg Glu Ile Lys Asp
     930                 935                 940

 caa aat gat cat aag tat cct ttt gat aga gca gaa aaa ttc aat cga     2880
 Gln Asn Asp His Lys Tyr Pro Phe Asp Arg Ala Glu Lys Phe Asn Arg
 945                 950                 955                 960

 ggc atc aga aaa ctt gga ata aca cct gag gga cag agc tac ctt gat     2928
 Gly Ile Arg Lys Leu Gly Ile Thr Pro Glu Gly Gln Ser Tyr Leu Asp
                 965                 970                 975

 caa ttc agg caa ctc atc agc cag att ggt aat gct atg ggc tat gta     2976
 Gln Phe Arg Gln Leu Ile Ser Gln Ile Gly Asn Ala Met Gly Tyr Val
             980                 985                 990

 cga atg ata aga tct ggt ggt ctt cat tgt agc agc aat gcc att aga     3024
 Arg Met Ile Arg Ser Gly Gly Leu His Cys Ser Ser Asn Ala Ile Arg
         995                1000                1005

 ttt gtt cct gat ctt gaa gat att gta aat ttt gaa gaa cta gta aaa     3072
 Phe Val Pro Asp Leu Glu Asp Ile Val Asn Phe Glu Glu Leu Val Lys
    1010                1015                1020

 gaa gaa ggt ctt gca gaa gaa aca tta aaa gca gca agg cat ttg gat     3120
 Glu Glu Gly Leu Ala Glu Glu Thr Leu Lys Ala Ala Arg His Leu Asp
1025                1030                1035                1040

 tca gtc ctc agt gat cac aca cga aat tct gcc gaa ggc aca gaa tat     3168
 Ser Val Leu Ser Asp His Thr Arg Asn Ser Ala Glu Gly Thr Glu Tyr
                1045                1050                1055

 ttc aaa atg ctt gta gac gtt ttt gct cca gaa ttt cga agg cca aag     3216
 Phe Lys Met Leu Val Asp Val Phe Ala Pro Glu Phe Arg Arg Pro Lys
            1060                1065                1070

 aat ata cat ctc cga aat ttc tat ata att gtt ccc cct ctg acc ctc     3264
 Asn Ile His Leu Arg Asn Phe Tyr Ile Ile Val Pro Pro Leu Thr Leu
        1075                1080                1085

 aac ttt gta gag cat tcc att agt tgc aag gaa aaa tta aat aaa aaa     3312
 Asn Phe Val Glu His Ser Ile Ser Cys Lys Glu Lys Leu Asn Lys Lys
    1090                1095                1100

 aat aaa att gga gct gcc ttt act gat gat ggc ttt gcc atg ggt gtg     3360
 Asn Lys Ile Gly Ala Ala Phe Thr Asp Asp Gly Phe Ala Met Gly Val
1105                1110                1115                1120

 gct tac att cta aag ctt ttg gat cag tat cgg gag ttt gat tca ctt     3408
 Ala Tyr Ile Leu Lys Leu Leu Asp Gln Tyr Arg Glu Phe Asp Ser Leu
                1125                1130                1135

 cac tgg ttc cag tct gtt aga gag aaa tac ctg aag gag ata aga gca     3456
 His Trp Phe Gln Ser Val Arg Glu Lys Tyr Leu Lys Glu Ile Arg Ala
            1140                1145                1150

 gtt gct aag caa cag aat gta cag tca gcc agt caa gat gaa aaa ctc     3504
 Val Ala Lys Gln Gln Asn Val Gln Ser Ala Ser Gln Asp Glu Lys Leu
        1155                1160                1165

 tta caa acc atg aat ctc act cag aag cga ctg gat gtc tat cta cag     3552
 Leu Gln Thr Met Asn Leu Thr Gln Lys Arg Leu Asp Val Tyr Leu Gln
    1170                1175                1180

 gaa ttt gaa ttg ctg tat ttc tca ctg agc agt gca aga att ttc ttc     3600
 Glu Phe Glu Leu Leu Tyr Phe Ser Leu Ser Ser Ala Arg Ile Phe Phe
1185                1190                1195                1200

 aga gca gac aag act gcg gct gaa gaa aac caa gaa aag aaa gag aag     3648
 Arg Ala Asp Lys Thr Ala Ala Glu Glu Asn Gln Glu Lys Lys Glu Lys
                1205                1210                1215

 gaa gaa gaa act aaa aca agc aat gga gac ctg tct gac agc act gtg     3696
 Glu Glu Glu Thr Lys Thr Ser Asn Gly Asp Leu Ser Asp Ser Thr Val
            1220                1225                1230

 tct gct gat cct gtt gtg aaa tg atacggatgg tattcactgc acatatgatg     3749
 Ser Ala Asp Pro Val Val Lys 
        1235

 aaatcatcag aattgttaaa acttttgcca gtggaatgga taaactattg atgaattgtt   3809

 tcctgggtca catctctgga aaatagatgt tacagttctt aaaggcagtg ctttaaagtg   3869

 aagttcattc tgtttccaaa ggctctactt tcaaaggtta agaatgagat tttaaaattg   3929

 gatttttgcc tggacttgag ggtacaagat gtttctattt gaagtgaagt tataaaaggg   3989

 caaatccaga ttcataaact atcacctcgg atttcttgta atctacatgt ttgtaatttg   4049

 tatttgcata gatctttgat ctatagttat ttcaagtcat gggaaattca atgcatatag   4109

 tatatacagc cagtaaatac atgcttaaca aaaggaatga gcctgaagtt cataaagaat   4169

 acatatcaat attcttataa aaggaatata tgaagatggc tttgatacta gaggtgaggc   4229

 acaagtgttt tatgtactct cagtgtacag tataactgat gatccttctt tcattgttaa   4289

 tttcatgtga ctcacaagag ctgctgatgt ctttgatgag acattttata actagtttac   4349

 attgctttga gaacatttaa cctccaacag ctgctttaaa tttaagattt acttaatact   4409

 cagaaaattc agataaagcc atagagtcct gtttgaagct tcacttctat tttggttgaa   4469

 ggcatgatgt atgatgtcag aaaaaaaatt gaatgaatta tttctacatc caaactcagg   4529

 tttcttctac attagattga attgaaattt tggtgatggt ttgggtagac ttttttttta   4589

 tatcaagtat aatttaaaac atcagattaa ataattacac tgttcaggct tttaaaaaaa   4649

 taccactgtg agaataaagc gctagtaaga tacatcactt actgatttta aaaatacaga   4709

 aagattttga gtaaattttg tgcccagcaa gctgttagtt ttatttttgt aaaggtatgt   4769

 aagttattaa atggttaatc atggcctttt aaaaataaaa taaagtgata cctttacaat   4829

 gaagacaaaa gtttaaaact ttctaataca aacaccattt tgggaaatgc ttgatttttt   4889

 tctattgcat ttgtctgcta aacatttctt tggataaatc ctgcaaatac ttctaacatt   4949

 attctttgat tccagctttt agaatgggtg tacaatgccc tgtttgtact tactggttag   5009

 ggtcagggta acttgccagc ccaagataaa tactttaatc gttaaaagtc agaagagaca   5069

 gaatatgtag gaaatgtttt ttgtttatta tgtaaacatg gcttacagaa ttatgaacag   5129

 tggatagatt aaaggcattt aatatttgta attcataata actgtagaaa tggccctaaa   5189

 gcatgctgca taattaataa tttatatttt cattattata agtgtttata ttaatgatct   5249

 tgcatttgat tatatcaaat tcgtcatttc atagcaacag tattgttttc tctgtttttc   5309

 ttctctaact tctctgaaat catctcctat taagggatag aaattgttac tagaagagaa   5369

 tcacatgttc tgtgttcatt atccctacac atgtaaatta attattttat caatactaga   5429

 tagagttcac atgctgactc cctggatacc tacagttgag aagaaaatga cagacaatta   5489

 tttttccttt aggtcaaaat aatgtcactg ctatctggat aaattataag ttcatatatt   5549

 tgaaataaga tcctggaaac gaatttaaat ggtgtcaaac tgcagagcaa cagggcttca   5609

 gtatattcac atctaatagg ttaatatgta catttggatg atgatttttc ttgataacat   5669

 taacattaat tttatttttt cagacatact gtaatttaaa aattaatgtg agcgtttgtt   5729

 ttaagttcac agaaaactta ataattcaaa ttctcaggaa ttaaggactc accataacat   5789

 tgtcagttcc aatgaaattt tgtaaaagat ggcaagtttg ttacctcact tgagtggggt   5849

 tttccttttc ccccaattct aagagaatat aatgtgtata ctaaaacatt aataaacata   5909

 attttgaaaa tttcaaaaaa aaaa                                          5933




      <210> 16
      <211> 762
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (236)..(616)

      <400> 16
 tctgcctaag aagtccaagg ctaaagaata agccttagcc ctccgcgtgc ccgcgggtct     60

 gtctcttgct tcaacagtgt ttggacggaa cagatccggg gactctcttc cagcctccga    120

 ccgccctccg atttcctctc cgcttgcaac ctccgggacc atcttctcgg ccatctcctg    180

 cttctgggac ctgccagcac cgtttttgtg gttagctcct tcttgccaac caacc atg     238
                                                              Met
                                                                1

 agc tcc cag att cgt cag aat tat tcc acc gac gtg gag gca gcc gtc      286
 Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala Val
               5                  10                  15

 aac agc ctg gtc aat ttg tac ctg cag gcc tcc tac acc tac ctc tct      334
 Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu Ser
          20                  25                  30

 ctg ggc ttc tat ttc gac cgc gat gat gtg gct ctg gaa ggc gtg agc      382
 Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val Ser
      35                  40                  45

 cac ttc ttc cgc gaa ttg gcc gag gag aag cgc gag ggc tac gag cgt      430
 His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg
  50                  55                  60                  65

 ctc ctg aag atg caa aac cag cgt ggc ggc cgc gct ctc ttc cag gac      478
 Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp
                  70                  75                  80

 atc aag aag cca gct gaa gat gag tgg ggt aaa acc cca gac gcc atg      526
 Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala Met
              85                  90                  95

 aaa gct gcc atg gcc ctg gag aaa aag ctg aac cag gcc ctt ttg gat      574
 Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp
         100                 105                 110

 ctt cat gcc atg ggt tct gcc cgc acg gac ccc cat ctc atg tgacttc      623
 Leu His Ala Met Gly Ser Ala Arg Thr Asp Pro His Leu Met 
     115                 120                 125

 ctggagcctc acttcataga tgaggaagtg aagcttatca agaagatggg ggaccacctg    683

 tccatcctac acaggctggg tggcgcgcag gctgggctgg gcgagtatct ctcagtaagg    743

 ctcgctctca agcacagat                                                 762




      <210> 17
      <211> 1362
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (259)..(1182)

      <400> 17
 cgcttatttg gagactagag gagtgacaat ccactttaat aatccagctt cagctcagct     60

 gagaacttcc cctctcaggt gcaaagggat ggcagagaag tctttccaag agggctcaat    120

 ccactaagag attatggctt agagaaggga acagctcaaa gaagcccttg aagagggtga    180

 gggtctggag gactcctgtg gtgcaggcca tctcccggat agagtgccgg acgcgtgggc    240

 tggtgagaag acagcgaa  atg gcg cct ccg gcc ccc ggc ccg gcc tcc ggc     291
                      Met Ala Pro Pro Ala Pro Gly Pro Ala Ser Gly
                        1               5                  10

 ggc tcc ggg gag gta gac gag ctg ttc gac gta aag aac gcc ttc tac      339
 Gly Ser Gly Glu Val Asp Glu Leu Phe Asp Val Lys Asn Ala Phe Tyr
              15                  20                  25

 atc ggc agc tac cag cag tgc ata aac gag gcg cag cgg gtg aag cta      387
 Ile Gly Ser Tyr Gln Gln Cys Ile Asn Glu Ala Gln Arg Val Lys Leu
          30                  35                  40

 tca agc cca gag aga gac gtg gag agg gac gtc ttc ctg tat aga gcg      435
 Ser Ser Pro Glu Arg Asp Val Glu Arg Asp Val Phe Leu Tyr Arg Ala
      45                  50                  55

 tac ctg gcg cag agg aag ttc ggt gtg gtc ctg gat gag atc aag ccc      483
 Tyr Leu Ala Gln Arg Lys Phe Gly Val Val Leu Asp Glu Ile Lys Pro
  60                  65                  70                  75

 tcc tcg gcc cct gag ctc cag gcc gtg cgc atg ttt gct gac tac ctc      531
 Ser Ser Ala Pro Glu Leu Gln Ala Val Arg Met Phe Ala Asp Tyr Leu
                  80                  85                  90

 gcc cac gag agt cgg agg gac agc atc gtg gcc gag ctg gac cga gag      579
 Ala His Glu Ser Arg Arg Asp Ser Ile Val Ala Glu Leu Asp Arg Glu
              95                 100                 105

 atg agc agg agc gtg gac gtg acc aac acc acc ttc ctg ctc atg gcc      627
 Met Ser Arg Ser Val Asp Val Thr Asn Thr Thr Phe Leu Leu Met Ala
         110                 115                 120

 gcc tcc atc tat ctc cac gac cag aac ccg gat gcc gcc ctg cgt gcg      675
 Ala Ser Ile Tyr Leu His Asp Gln Asn Pro Asp Ala Ala Leu Arg Ala
     125                 130                 135

 ctg cac cag ggg gac agc ctg gag tgc aca gcc atg aca gtg cag atc      723
 Leu His Gln Gly Asp Ser Leu Glu Cys Thr Ala Met Thr Val Gln Ile
 140                 145                 150                 155

 ctg ctg aag ctg gac cgc ctg gac ctc gcc cgg aag gag ctg aag aga      771
 Leu Leu Lys Leu Asp Arg Leu Asp Leu Ala Arg Lys Glu Leu Lys Arg
                 160                 165                 170

 atg cag gac ctg gac gag gat gcc acc ctc acc cag ctc gcc act gcc      819
 Met Gln Asp Leu Asp Glu Asp Ala Thr Leu Thr Gln Leu Ala Thr Ala
             175                 180                 185

 tgg gtc agc ctg gcc acg ggt ggt gag aag ctg cag gat gcc tac tac      867
 Trp Val Ser Leu Ala Thr Gly Gly Glu Lys Leu Gln Asp Ala Tyr Tyr
         190                 195                 200

 atc ttc cag gag atg gct gac aag tgc tcg ccc acc ctg ctg ctg ctc      915
 Ile Phe Gln Glu Met Ala Asp Lys Cys Ser Pro Thr Leu Leu Leu Leu
     205                 210                 215

 aat ggg cag gcg gcc tgc cac atg gcc cag ggc cgc tgg gag gcc gct      963
 Asn Gly Gln Ala Ala Cys His Met Ala Gln Gly Arg Trp Glu Ala Ala
 220                 225                 230                 235

 gag ggc ctg ctg cag gag gcg cta gac aag gat agt ggc tac ccg gag     1011
 Glu Gly Leu Leu Gln Glu Ala Leu Asp Lys Asp Ser Gly Tyr Pro Glu
                 240                 245                 250

 acg ctg gtc aac ctc atc gtc ctg tcc cag cac ctg ggc aag ccc cct     1059
 Thr Leu Val Asn Leu Ile Val Leu Ser Gln His Leu Gly Lys Pro Pro
             255                 260                 265

 gag gtg aca aac cga tac ctg tcc cag ctg aag gat gcc cac agg tcc     1107
 Glu Val Thr Asn Arg Tyr Leu Ser Gln Leu Lys Asp Ala His Arg Ser
         270                 275                 280

 cat ccc ttc atc aag gag tac cag gcc aag gag aac gac ttt gac agg     1155
 His Pro Phe Ile Lys Glu Tyr Gln Ala Lys Glu Asn Asp Phe Asp Arg
     285                 290                 295

 ctg gtg cta cag tac gct ccc agc gcc tgagg ctggcccaga gctgtcagga     1207
 Leu Val Leu Gln Tyr Ala Pro Ser Ala 
 300                 305

 ccatgaagcc aggacagagg ccaggagcca gccctgcagc cctccccacc cggcatccac   1267

 ctgcatcccc tctgggggca ggagcccacc cccagcaccc ccatctgtta ataaatatct   1327

 caactccagg gtgttccacc tgaaaaaaaa aaaaa                              1362




      <210> 18
      <211> 12505
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (197)..(9964)

      <400> 18
 ctaccgggcg gaggtgagcg cggcgccggc tcctcctgcg gcggactttg ggtgcgactt     60

 gacgagcggt ggttcgacaa gtggccttgc gggccggatc gtcccagtgg aagagttgta    120

 aatttgcttc tggccttccc ctacggatta tacctggcct tcccctacgg attatactca    180

 acttactgtt tagaaa    atg tgg ccc acg aga cgc ctg gtt act atc aaa     229
                      Met Trp Pro Thr Arg Arg Leu Val Thr Ile Lys
                        1               5                  10

 agg agc ggg gtc gac ggt ccc cac ttt ccc ctg agc ctc agc acc tgc      277
 Arg Ser Gly Val Asp Gly Pro His Phe Pro Leu Ser Leu Ser Thr Cys
              15                  20                  25

 ttg ttt gga agg ggt att gaa tgt gac atc cgt atc cag ctt cct gtt      325
 Leu Phe Gly Arg Gly Ile Glu Cys Asp Ile Arg Ile Gln Leu Pro Val
          30                  35                  40

 gtg tca aaa caa cat tgc aaa att gaa atc cat gag cag gag gca ata      373
 Val Ser Lys Gln His Cys Lys Ile Glu Ile His Glu Gln Glu Ala Ile
      45                  50                  55

 tta cat aat ttc agt tcc aca aat cca aca caa gta aat ggg tct gtt      421
 Leu His Asn Phe Ser Ser Thr Asn Pro Thr Gln Val Asn Gly Ser Val
  60                  65                  70                  75

 att gat gag cct gta cgg cta aaa cat gga gat gta ata act att att      469
 Ile Asp Glu Pro Val Arg Leu Lys His Gly Asp Val Ile Thr Ile Ile
                  80                  85                  90

 gat cgt tcc ttc agg tat gaa aat gaa agt ctt cag aat gga agg aag      517
 Asp Arg Ser Phe Arg Tyr Glu Asn Glu Ser Leu Gln Asn Gly Arg Lys
              95                 100                 105

 tca act gaa ttt cca aga aaa ata cgt gaa cag gag cca gca cgt cgt      565
 Ser Thr Glu Phe Pro Arg Lys Ile Arg Glu Gln Glu Pro Ala Arg Arg
         110                 115                 120

 gtc tca aga tct agc ttc tct tct gac cct gat gag aaa gct caa gat      613
 Val Ser Arg Ser Ser Phe Ser Ser Asp Pro Asp Glu Lys Ala Gln Asp
     125                 130                 135

 tcc aag gcc tat tca aaa atc act gaa gga aaa gtt tca gga aat cct      661
 Ser Lys Ala Tyr Ser Lys Ile Thr Glu Gly Lys Val Ser Gly Asn Pro
 140                 145                 150                 155

 cag gta cat atc aag aat gtc aaa gaa gac agt acc gca gat gac tca      709
 Gln Val His Ile Lys Asn Val Lys Glu Asp Ser Thr Ala Asp Asp Ser
                 160                 165                 170

 aaa gac agt gtt gct cag gga aca act aat gtt cat tcc tca gaa cat      757
 Lys Asp Ser Val Ala Gln Gly Thr Thr Asn Val His Ser Ser Glu His
             175                 180                 185

 gct gga cgt aat ggc aga aat gca gct gat ccc att tct ggg gat ttt      805
 Ala Gly Arg Asn Gly Arg Asn Ala Ala Asp Pro Ile Ser Gly Asp Phe
         190                 195                 200

 aaa gaa att tcc agc gtt aaa tta gtg agc cgt tat gga gaa ttg aag      853
 Lys Glu Ile Ser Ser Val Lys Leu Val Ser Arg Tyr Gly Glu Leu Lys
     205                 210                 215

 tct gtt ccc act aca caa tgt ctt gac aat agc aaa aaa aat gaa tct      901
 Ser Val Pro Thr Thr Gln Cys Leu Asp Asn Ser Lys Lys Asn Glu Ser
 220                 225                 230                 235

 ccc ttt tgg aag ctt tat gag tca gtg aag aaa gag ttg gat gta aaa      949
 Pro Phe Trp Lys Leu Tyr Glu Ser Val Lys Lys Glu Leu Asp Val Lys
                 240                 245                 250

 tca caa aaa gaa aat gtc cta cag tat tgt aga aaa tct gga tta caa      997
 Ser Gln Lys Glu Asn Val Leu Gln Tyr Cys Arg Lys Ser Gly Leu Gln
             255                 260                 265

 act gat tac gca aca gag aaa gaa agt gct gat ggt tta cag ggg gag     1045
 Thr Asp Tyr Ala Thr Glu Lys Glu Ser Ala Asp Gly Leu Gln Gly Glu
         270                 275                 280

 acc caa ctg ttg gtc tcg cgt aag tca aga cca aaa tct ggt ggg agc     1093
 Thr Gln Leu Leu Val Ser Arg Lys Ser Arg Pro Lys Ser Gly Gly Ser
     285                 290                 295

 ggc cac gct gtg gca gag cct gct tca cct gaa caa gag ctt gac cag     1141
 Gly His Ala Val Ala Glu Pro Ala Ser Pro Glu Gln Glu Leu Asp Gln
 300                 305                 310                 315

 aac aag ggg aag gga aga gac gtg gag tct gtt cag act ccc agc aag     1189
 Asn Lys Gly Lys Gly Arg Asp Val Glu Ser Val Gln Thr Pro Ser Lys
                 320                 325                 330

 gct gtg ggc gcc agc ttt cct ctc tat gag ccg gct aaa atg aag acc     1237
 Ala Val Gly Ala Ser Phe Pro Leu Tyr Glu Pro Ala Lys Met Lys Thr
             335                 340                 345

 cct gta caa tat tca cag caa caa aat tct cca caa aaa cat aag aac     1285
 Pro Val Gln Tyr Ser Gln Gln Gln Asn Ser Pro Gln Lys His Lys Asn
         350                 355                 360

 aaa gac ctg tat act act ggt aga aga gaa tct gtg aat ctg ggt aaa     1333
 Lys Asp Leu Tyr Thr Thr Gly Arg Arg Glu Ser Val Asn Leu Gly Lys
     365                 370                 375

 agt gaa ggc ttc aag gct ggt gat aaa act ctt act ccc agg aag ctt     1381
 Ser Glu Gly Phe Lys Ala Gly Asp Lys Thr Leu Thr Pro Arg Lys Leu
 380                 385                 390                 395

 tca act aga aat cga aca cca gct aaa gtt gaa gat gca gct gac tct     1429
 Ser Thr Arg Asn Arg Thr Pro Ala Lys Val Glu Asp Ala Ala Asp Ser
                 400                 405                 410

 gcc act aag cca gaa aat ctc tct tcc aaa acc aga gga agt att cct     1477
 Ala Thr Lys Pro Glu Asn Leu Ser Ser Lys Thr Arg Gly Ser Ile Pro
             415                 420                 425

 aca gat gtg gaa gtt ctg cct acg gaa act gaa att cac aat gag cca     1525
 Thr Asp Val Glu Val Leu Pro Thr Glu Thr Glu Ile His Asn Glu Pro
         430                 435                 440

 ttt tta act ctg tgg ctc act caa gtt gag agg aag atc caa aag gat     1573
 Phe Leu Thr Leu Trp Leu Thr Gln Val Glu Arg Lys Ile Gln Lys Asp
     445                 450                 455

 tcc ctc agc aag cct gag aaa ttg ggc act aca gct gga cag atg tgc     1621
 Ser Leu Ser Lys Pro Glu Lys Leu Gly Thr Thr Ala Gly Gln Met Cys
 460                 465                 470                 475

 tct ggg tta cct ggt ctt agt tca gtt gat atc aac aac ttt ggt gat     1669
 Ser Gly Leu Pro Gly Leu Ser Ser Val Asp Ile Asn Asn Phe Gly Asp
                 480                 485                 490

 tcc att aat gag agt gag gga ata cct ttg aaa aga agg cgt gtg tcc     1717
 Ser Ile Asn Glu Ser Glu Gly Ile Pro Leu Lys Arg Arg Arg Val Ser
             495                 500                 505

 ttt ggt ggg cac cta aga cct gaa cta ttt gat gaa aac ttg cct cct     1765
 Phe Gly Gly His Leu Arg Pro Glu Leu Phe Asp Glu Asn Leu Pro Pro
         510                 515                 520

 aat acg cct ctc aaa agg gga gaa gcc cca acc aaa aga aag tct ctg     1813
 Asn Thr Pro Leu Lys Arg Gly Glu Ala Pro Thr Lys Arg Lys Ser Leu
     525                 530                 535

 gta atg cac act cca cct gtc ctg aag aaa atc atc aag gaa cag cct     1861
 Val Met His Thr Pro Pro Val Leu Lys Lys Ile Ile Lys Glu Gln Pro
 540                 545                 550                 555

 caa cca tca gga aaa caa gag tca ggt tca gaa atc cat gtg gaa gtg     1909
 Gln Pro Ser Gly Lys Gln Glu Ser Gly Ser Glu Ile His Val Glu Val
                 560                 565                 570

 aag gca caa agc ttg gtt ata agc cct cca gct cct agt cct agg aaa     1957
 Lys Ala Gln Ser Leu Val Ile Ser Pro Pro Ala Pro Ser Pro Arg Lys
             575                 580                 585

 act cca gtt gcc agt gat caa cgc cgt agg tcc tgc aaa aca gcc cct     2005
 Thr Pro Val Ala Ser Asp Gln Arg Arg Arg Ser Cys Lys Thr Ala Pro
         590                 595                 600

 gct tcc agc agc aaa tct cag aca gag gtt cct aag aga gga gga gaa     2053
 Ala Ser Ser Ser Lys Ser Gln Thr Glu Val Pro Lys Arg Gly Gly Glu
     605                 610                 615

 aga gtg gca acc tgc ctt caa aag aga gtg tct atc agc cga agt caa     2101
 Arg Val Ala Thr Cys Leu Gln Lys Arg Val Ser Ile Ser Arg Ser Gln
 620                 625                 630                 635

 cat gat att tta cag atg ata tgt tcc aaa aga aga agt ggt gct tcg     2149
 His Asp Ile Leu Gln Met Ile Cys Ser Lys Arg Arg Ser Gly Ala Ser
                 640                 645                 650

 gaa gca aat ctg att gtt gca aaa tca tgg gca gat gta gta aaa ctt     2197
 Glu Ala Asn Leu Ile Val Ala Lys Ser Trp Ala Asp Val Val Lys Leu
             655                 660                 665

 ggt gca aaa caa aca caa act aaa gtc ata aaa cat ggt cct caa agg     2245
 Gly Ala Lys Gln Thr Gln Thr Lys Val Ile Lys His Gly Pro Gln Arg
         670                 675                 680

 tca atg aac aaa agg caa aga aga cct gct act cca aag aag cct gtg     2293
 Ser Met Asn Lys Arg Gln Arg Arg Pro Ala Thr Pro Lys Lys Pro Val
     685                 690                 695

 ggc gaa gtt cac agt caa ttt agt aca ggc cac gca aac tct cct tgt     2341
 Gly Glu Val His Ser Gln Phe Ser Thr Gly His Ala Asn Ser Pro Cys
 700                 705                 710                 715

 acc ata ata ata ggg aaa gct cat act gaa aaa gta cat gtg cct gct     2389
 Thr Ile Ile Ile Gly Lys Ala His Thr Glu Lys Val His Val Pro Ala
                 720                 725                 730

 cga ccc tac aga gtg ctc aac aac ttc att tcc aac caa aaa atg gac     2437
 Arg Pro Tyr Arg Val Leu Asn Asn Phe Ile Ser Asn Gln Lys Met Asp
             735                 740                 745

 ttt aag gaa gat ctt tca gga ata gct gaa atg ttc aag acc cca gtg     2485
 Phe Lys Glu Asp Leu Ser Gly Ile Ala Glu Met Phe Lys Thr Pro Val
         750                 755                 760

 aag gag caa ccg cag ttg aca agc aca tgt cac atc gct att tca aat     2533
 Lys Glu Gln Pro Gln Leu Thr Ser Thr Cys His Ile Ala Ile Ser Asn
     765                 770                 775

 tca gag aat ttg ctt gga aaa cag ttt caa gga act gat tca gga gaa     2581
 Ser Glu Asn Leu Leu Gly Lys Gln Phe Gln Gly Thr Asp Ser Gly Glu
 780                 785                 790                 795

 gaa cct ctg ctc ccc acc tca gag agt ttt gga gga aat gtg ttc ttc     2629
 Glu Pro Leu Leu Pro Thr Ser Glu Ser Phe Gly Gly Asn Val Phe Phe
                 800                 805                 810

 agt gca cag aat gca gca aaa cag cca tct gat aaa tgc tct gca agc     2677
 Ser Ala Gln Asn Ala Ala Lys Gln Pro Ser Asp Lys Cys Ser Ala Ser
             815                 820                 825

 cct ccc tta aga cgg cag tgt att aga gaa aat gga aac gta gca aaa     2725
 Pro Pro Leu Arg Arg Gln Cys Ile Arg Glu Asn Gly Asn Val Ala Lys
         830                 835                 840

 acg ccc agg aac acc tac aaa atg act tct ctg gag aca aaa act tca     2773
 Thr Pro Arg Asn Thr Tyr Lys Met Thr Ser Leu Glu Thr Lys Thr Ser
     845                 850                 855

 gat act gag aca gag cct tca aaa aca gta tcc act gta aac agg tca     2821
 Asp Thr Glu Thr Glu Pro Ser Lys Thr Val Ser Thr Val Asn Arg Ser
 860                 865                 870                 875

 gga agg tct aca gag ttc agg aat ata cag aag cta cct gtg gaa agt     2869
 Gly Arg Ser Thr Glu Phe Arg Asn Ile Gln Lys Leu Pro Val Glu Ser
                 880                 885                 890

 aag agt gaa gaa aca aat aca gaa att gtt gag tgc atc cta aaa aga     2917
 Lys Ser Glu Glu Thr Asn Thr Glu Ile Val Glu Cys Ile Leu Lys Arg
             895                 900                 905

 ggt cag aag gca aca cta cta caa caa agg aga gaa gga gag atg aag     2965
 Gly Gln Lys Ala Thr Leu Leu Gln Gln Arg Arg Glu Gly Glu Met Lys
         910                 915                 920

 gaa ata gaa aga cct ttt gag aca tat aag gaa aat att gaa tta aaa     3013
 Glu Ile Glu Arg Pro Phe Glu Thr Tyr Lys Glu Asn Ile Glu Leu Lys
     925                 930                 935

 gaa aac gat gaa aag atg aaa gca atg aag aga tca aga act tgg ggg     3061
 Glu Asn Asp Glu Lys Met Lys Ala Met Lys Arg Ser Arg Thr Trp Gly
 940                 945                 950                 955

 cag aaa tgt gca cca atg tct gac ctg aca gac ctc aag agc ttg cct     3109
 Gln Lys Cys Ala Pro Met Ser Asp Leu Thr Asp Leu Lys Ser Leu Pro
                 960                 965                 970

 gat aca gaa ctc atg aaa gac acg gca cgt ggc cag aat ctc ctc caa     3157
 Asp Thr Glu Leu Met Lys Asp Thr Ala Arg Gly Gln Asn Leu Leu Gln
             975                 980                 985

 acc caa gat cat gcc aag gca cca aag agt gag aaa ggc aaa atc act     3205
 Thr Gln Asp His Ala Lys Ala Pro Lys Ser Glu Lys Gly Lys Ile Thr
         990                 995                1000

 aaa atg ccc tgc cag tca tta caa cca gaa cca ata aac acc cca aca     3253
 Lys Met Pro Cys Gln Ser Leu Gln Pro Glu Pro Ile Asn Thr Pro Thr
    1005                1010                1015

 cac aca aaa caa cag ttg aag gca tcc ctg ggg aaa gta ggt gtg aaa     3301
 His Thr Lys Gln Gln Leu Lys Ala Ser Leu Gly Lys Val Gly Val Lys
1020                1025                1030                1035

 gaa gag ctc cta gca gtc ggc aag ttc aca cgg acg tca ggg gag acc     3349
 Glu Glu Leu Leu Ala Val Gly Lys Phe Thr Arg Thr Ser Gly Glu Thr
                1040                1045                1050

 acg cac acg cac aga gag cca gca gga gat ggc aag agc atc aga acg     3397
 Thr His Thr His Arg Glu Pro Ala Gly Asp Gly Lys Ser Ile Arg Thr
            1055                1060                1065

 ttt aag gag tct cca aag cag atc ctg gac cca gca gcc cgt gta act     3445
 Phe Lys Glu Ser Pro Lys Gln Ile Leu Asp Pro Ala Ala Arg Val Thr
        1070                1075                1080

 gga atg aag aag tgg cca aga acg cct aag gaa gag gcc cag tca cta     3493
 Gly Met Lys Lys Trp Pro Arg Thr Pro Lys Glu Glu Ala Gln Ser Leu
    1085                1090                1095

 gaa gac ctg gct ggc ttc aaa gag ctc ttc cag aca cca ggt ccc tct     3541
 Glu Asp Leu Ala Gly Phe Lys Glu Leu Phe Gln Thr Pro Gly Pro Ser
1100                1105                1110                1115

 gag gaa tca atg act gat gag aaa act acc aaa ata gcc tgc aaa tct     3589
 Glu Glu Ser Met Thr Asp Glu Lys Thr Thr Lys Ile Ala Cys Lys Ser
                1120                1125                1130

 cca cca cca gaa tca gtg gac act cca aca agc aca aag caa tgg cct     3637
 Pro Pro Pro Glu Ser Val Asp Thr Pro Thr Ser Thr Lys Gln Trp Pro
            1135                1140                1145

 aag aga agt ctc agg aaa gca gat gta gag gaa gaa ttc tta gca ctc     3685
 Lys Arg Ser Leu Arg Lys Ala Asp Val Glu Glu Glu Phe Leu Ala Leu
        1150                1155                1160

 agg aaa cta aca cca tca gca ggg aaa gcc atg ctt acg ccc aaa cca     3733
 Arg Lys Leu Thr Pro Ser Ala Gly Lys Ala Met Leu Thr Pro Lys Pro
    1165                1170                1175

 gca gga ggt gat gag aaa gac att aaa gca ttt atg gga act cca gtg     3781
 Ala Gly Gly Asp Glu Lys Asp Ile Lys Ala Phe Met Gly Thr Pro Val
1180                1185                1190                1195

 cag aaa ctg gac ctg gca gga act tta cct ggc agc aaa aga cag cta     3829
 Gln Lys Leu Asp Leu Ala Gly Thr Leu Pro Gly Ser Lys Arg Gln Leu
                1200                1205                1210

 cag act cct aag gaa aag gcc cag gct cta gaa gac ctg gct ggc ttt     3877
 Gln Thr Pro Lys Glu Lys Ala Gln Ala Leu Glu Asp Leu Ala Gly Phe
            1215                1220                1225

 aaa gag ctc ttc cag act cct ggt cac acc gag gaa tta gtg gct gct     3925
 Lys Glu Leu Phe Gln Thr Pro Gly His Thr Glu Glu Leu Val Ala Ala
        1230                1235                1240

 ggt aaa acc act aaa ata ccc tgc gac tct cca cag tca gac cca gtg     3973
 Gly Lys Thr Thr Lys Ile Pro Cys Asp Ser Pro Gln Ser Asp Pro Val
    1245                1250                1255

 gac acc cca aca agc aca aag caa cga ccc aag aga agt atc agg aaa     4021
 Asp Thr Pro Thr Ser Thr Lys Gln Arg Pro Lys Arg Ser Ile Arg Lys
1260                1265                1270                1275

 gca gat gta gag gga gaa ctc tta gcg tgc agg aat cta atg cca tca     4069
 Ala Asp Val Glu Gly Glu Leu Leu Ala Cys Arg Asn Leu Met Pro Ser
                1280                1285                1290

 gca ggc aaa gcc atg cac acg cct aaa cca tca gta ggt gaa gag aaa     4117
 Ala Gly Lys Ala Met His Thr Pro Lys Pro Ser Val Gly Glu Glu Lys
            1295                1300                1305

 gac atc atc ata ttt gtg gga act cca gtg cag aaa ctg gac ctg aca     4165
 Asp Ile Ile Ile Phe Val Gly Thr Pro Val Gln Lys Leu Asp Leu Thr
        1310                1315                1320

 gag aac tta acc ggc agc aag aga cgg cca caa act cct aag gaa gag     4213
 Glu Asn Leu Thr Gly Ser Lys Arg Arg Pro Gln Thr Pro Lys Glu Glu
    1325                1330                1335

 gcc cag gct ctg gaa gac ctg act ggc ttt aaa gag ctc ttc cag acc     4261
 Ala Gln Ala Leu Glu Asp Leu Thr Gly Phe Lys Glu Leu Phe Gln Thr
1340                1345                1350                1355

 cct ggt cat act gaa gaa gca gtg gct gct ggc aaa act act aaa atg     4309
 Pro Gly His Thr Glu Glu Ala Val Ala Ala Gly Lys Thr Thr Lys Met
                1360                1365                1370

 ccc tgc gaa tct tct cca cca gaa tca gca gac acc cca aca agc aca     4357
 Pro Cys Glu Ser Ser Pro Pro Glu Ser Ala Asp Thr Pro Thr Ser Thr
            1375                1380                1385

 aga agg cag ccc aag aca cct ttg gag aaa agg gac gta cag aag gag     4405
 Arg Arg Gln Pro Lys Thr Pro Leu Glu Lys Arg Asp Val Gln Lys Glu
        1390                1395                1400

 ctc tca gcc ctg aag aag ctc aca cag aca tca ggg gaa acc aca cac     4453
 Leu Ser Ala Leu Lys Lys Leu Thr Gln Thr Ser Gly Glu Thr Thr His
    1405                1410                1415

 aca gat aaa gta cca gga ggt gag gat aaa agc atc aac gcg ttt agg     4501
 Thr Asp Lys Val Pro Gly Gly Glu Asp Lys Ser Ile Asn Ala Phe Arg
1420                1425                1430                1435

 gaa act gca aaa cag aaa ctg gac cca gca gca agt gta act ggt agc     4549
 Glu Thr Ala Lys Gln Lys Leu Asp Pro Ala Ala Ser Val Thr Gly Ser
                1440                1445                1450

 aag agg cac cca aaa act aag gaa aag gcc caa ccc cta gaa gac ctg     4597
 Lys Arg His Pro Lys Thr Lys Glu Lys Ala Gln Pro Leu Glu Asp Leu
            1455                1460                1465

 gct ggc tgg aaa gag ctc ttc cag aca cca gta tgc act gac aag ccc     4645
 Ala Gly Trp Lys Glu Leu Phe Gln Thr Pro Val Cys Thr Asp Lys Pro
        1470                1475                1480

 acg act cac gag aaa act acc aaa ata gcc tgc aga tca caa cca gac     4693
 Thr Thr His Glu Lys Thr Thr Lys Ile Ala Cys Arg Ser Gln Pro Asp
    1485                1490                1495

 cca gtg gac aca cca aca agc tcc aag cca cag tcc aag aga agt ctc     4741
 Pro Val Asp Thr Pro Thr Ser Ser Lys Pro Gln Ser Lys Arg Ser Leu
1500                1505                1510                1515

 agg aaa gtg gac gta gaa gaa gaa ttc ttc gca ctc agg aaa cga aca     4789
 Arg Lys Val Asp Val Glu Glu Glu Phe Phe Ala Leu Arg Lys Arg Thr
                1520                1525                1530

 cca tca gca ggc aaa gcc atg cac aca ccc aaa cca gca gta agt ggt     4837
 Pro Ser Ala Gly Lys Ala Met His Thr Pro Lys Pro Ala Val Ser Gly
            1535                1540                1545

 gag aaa aac atc tac gca ttt atg gga act cca gtg cag aaa ctg gac     4885
 Glu Lys Asn Ile Tyr Ala Phe Met Gly Thr Pro Val Gln Lys Leu Asp
        1550                1555                1560

 ctg aca gag aac tta act ggc agc aag aga cgg cta caa act cct aag     4933
 Leu Thr Glu Asn Leu Thr Gly Ser Lys Arg Arg Leu Gln Thr Pro Lys
    1565                1570                1575

 gaa aag gcc cag gct cta gaa gac ctg gct ggc ttt aaa gag ctc ttc     4981
 Glu Lys Ala Gln Ala Leu Glu Asp Leu Ala Gly Phe Lys Glu Leu Phe
1580                1585                1590                1595

 cag aca cga ggt cac act gag gaa tca atg act aac gat aaa act gcc     5029
 Gln Thr Arg Gly His Thr Glu Glu Ser Met Thr Asn Asp Lys Thr Ala
                1600                1605                1610

 aaa gta gcc tgc aaa tct tca caa cca gac cta gac aaa aac cca gca     5077
 Lys Val Ala Cys Lys Ser Ser Gln Pro Asp Leu Asp Lys Asn Pro Ala
            1615                1620                1625

 agc tcc aag cga cgg ctc aag aca tcc ctg ggg aaa gtg ggc gtg aaa     5125
 Ser Ser Lys Arg Arg Leu Lys Thr Ser Leu Gly Lys Val Gly Val Lys
        1630                1635                1640

 gaa gag ctc cta gca gtt ggc aag ctc aca cag aca tca gga gag act     5173
 Glu Glu Leu Leu Ala Val Gly Lys Leu Thr Gln Thr Ser Gly Glu Thr
    1645                1650                1655

 aca cac aca cac aca gag cca aca gga gat ggt aag agc atg aaa gca     5221
 Thr His Thr His Thr Glu Pro Thr Gly Asp Gly Lys Ser Met Lys Ala
1660                1665                1670                1675

 ttt atg gag tct cca aag cag atc tta gac tca gca gca agt cta act     5269
 Phe Met Glu Ser Pro Lys Gln Ile Leu Asp Ser Ala Ala Ser Leu Thr
                1680                1685                1690

 ggc agc aag agg cag ctg aga act cct aag gga aag tct gaa gtc cct     5317
 Gly Ser Lys Arg Gln Leu Arg Thr Pro Lys Gly Lys Ser Glu Val Pro
            1695                1700                1705

 gaa gac ctg gcc ggc ttc atc gag ctc ttc cag aca cca agt cac act     5365
 Glu Asp Leu Ala Gly Phe Ile Glu Leu Phe Gln Thr Pro Ser His Thr
        1710                1715                1720

 aag gaa tca atg act aat gaa aaa act acc aaa gta tcc tac aga gct     5413
 Lys Glu Ser Met Thr Asn Glu Lys Thr Thr Lys Val Ser Tyr Arg Ala
    1725                1730                1735

 tca cag cca gac cta gtg gac acc cca aca agc tcc aag cca cag ccc     5461
 Ser Gln Pro Asp Leu Val Asp Thr Pro Thr Ser Ser Lys Pro Gln Pro
1740                1745                1750                1755

 aag aga agt ctc agg aaa gca gac act gaa gaa gaa ttt tta gca ttt     5509
 Lys Arg Ser Leu Arg Lys Ala Asp Thr Glu Glu Glu Phe Leu Ala Phe
                1760                1765                1770

 agg aaa caa acg cca tca gca ggc aaa gcc atg cac aca ccc aaa cca     5557
 Arg Lys Gln Thr Pro Ser Ala Gly Lys Ala Met His Thr Pro Lys Pro
            1775                1780                1785

 gca gta ggt gaa gag aaa gac atc aac acg ttt ttg gga act cca gtg     5605
 Ala Val Gly Glu Glu Lys Asp Ile Asn Thr Phe Leu Gly Thr Pro Val
        1790                1795                1800

 cag aaa ctg gac cag cca gga aat tta cct ggc agc aat aga cgg cta     5653
 Gln Lys Leu Asp Gln Pro Gly Asn Leu Pro Gly Ser Asn Arg Arg Leu
    1805                1810                1815

 caa act cgt aag gaa aag gcc cag gct cta gaa gaa ctg act ggc ttc     5701
 Gln Thr Arg Lys Glu Lys Ala Gln Ala Leu Glu Glu Leu Thr Gly Phe
1820                1825                1830                1835

 aga gag ctt ttc cag aca cca tgc act gat aac ccc aca gct gat gag     5749
 Arg Glu Leu Phe Gln Thr Pro Cys Thr Asp Asn Pro Thr Ala Asp Glu
                1840                1845                1850

 aaa act acc aaa aaa ata ctc tgc aaa tct ccg caa tca gac cca gcg     5797
 Lys Thr Thr Lys Lys Ile Leu Cys Lys Ser Pro Gln Ser Asp Pro Ala
            1855                1860                1865

 gac acc cca aca aac aca aag caa cgg ccc aag aga agc ctc aag aaa     5845
 Asp Thr Pro Thr Asn Thr Lys Gln Arg Pro Lys Arg Ser Leu Lys Lys
        1870                1875                1880

 gca gac gta gag gaa gaa ttt tta gca ttc agg aaa cta aca cca tca     5893
 Ala Asp Val Glu Glu Glu Phe Leu Ala Phe Arg Lys Leu Thr Pro Ser
    1885                1890                1895

 gca ggc aaa gcc atg cac acg cct aaa gca gca gta ggt gaa gag aaa     5941
 Ala Gly Lys Ala Met His Thr Pro Lys Ala Ala Val Gly Glu Glu Lys
1900                1905                1910                1915

 gac atc aac aca ttt gtg ggg act cca gtg gag aaa ctg gac ctg cta     5989
 Asp Ile Asn Thr Phe Val Gly Thr Pro Val Glu Lys Leu Asp Leu Leu
                1920                1925                1930

 gga aat tta cct ggc agc aag aga cgg cca caa act cct aaa gaa aag     6037
 Gly Asn Leu Pro Gly Ser Lys Arg Arg Pro Gln Thr Pro Lys Glu Lys
            1935                1940                1945

 gcc aag gct cta gaa gat ctg gct ggc ttc aaa gag ctc ttc cag aca     6085
 Ala Lys Ala Leu Glu Asp Leu Ala Gly Phe Lys Glu Leu Phe Gln Thr
        1950                1955                1960

 cca ggt cac act gag gaa tca atg acc gat gac aaa atc aca gaa gta     6133
 Pro Gly His Thr Glu Glu Ser Met Thr Asp Asp Lys Ile Thr Glu Val
    1965                1970                1975

 tcc tgc aaa tct cca caa cca gac cca gtc aaa acc cca aca agc tcc     6181
 Ser Cys Lys Ser Pro Gln Pro Asp Pro Val Lys Thr Pro Thr Ser Ser
1980                1985                1990                1995

 aag caa cga ctc aag ata tcc ttg ggg aaa gta ggt gtg aaa gaa gag     6229
 Lys Gln Arg Leu Lys Ile Ser Leu Gly Lys Val Gly Val Lys Glu Glu
                2000                2005                2010

 gtc cta cca gtc ggc aag ctc aca cag acg tca ggg aag acc aca cag     6277
 Val Leu Pro Val Gly Lys Leu Thr Gln Thr Ser Gly Lys Thr Thr Gln
            2015                2020                2025

 aca cac aga gag aca gca gga gat gga aag agc atc aaa gcg ttt aag     6325
 Thr His Arg Glu Thr Ala Gly Asp Gly Lys Ser Ile Lys Ala Phe Lys
        2030                2035                2040

 gaa tct gca aag cag atg ctg gac cca gca aac tat gga act ggg atg     6373
 Glu Ser Ala Lys Gln Met Leu Asp Pro Ala Asn Tyr Gly Thr Gly Met
    2045                2050                2055

 gag agg tgg cca aga aca cct aag gaa gag gcc caa tca cta gaa gac     6421
 Glu Arg Trp Pro Arg Thr Pro Lys Glu Glu Ala Gln Ser Leu Glu Asp
2060                2065                2070                2075

 ctg gcc ggc ttc aaa gag ctc ttc cag aca cca gac cac act gag gaa     6469
 Leu Ala Gly Phe Lys Glu Leu Phe Gln Thr Pro Asp His Thr Glu Glu
                2080                2085                2090

 tca aca act gat gac aaa act acc aaa ata gcc tgc aaa tct cca cca     6517
 Ser Thr Thr Asp Asp Lys Thr Thr Lys Ile Ala Cys Lys Ser Pro Pro
            2095                2100                2105

 cca gaa tca atg gac act cca aca agc aca agg agg cgg ccc aaa aca     6565
 Pro Glu Ser Met Asp Thr Pro Thr Ser Thr Arg Arg Arg Pro Lys Thr
        2110                2115                2120

 cct ttg ggg aaa agg gat ata gtg gaa gag ctc tca gcc ctg aag cag     6613
 Pro Leu Gly Lys Arg Asp Ile Val Glu Glu Leu Ser Ala Leu Lys Gln
    2125                2130                2135

 ctc aca cag acc aca cac aca gac aaa gta cca gga gat gag gat aaa     6661
 Leu Thr Gln Thr Thr His Thr Asp Lys Val Pro Gly Asp Glu Asp Lys
2140                2145                2150                2155

 ggc atc aac gtg ttc agg gaa act gca aaa cag aaa ctg gac cca gca     6709
 Gly Ile Asn Val Phe Arg Glu Thr Ala Lys Gln Lys Leu Asp Pro Ala
                2160                2165                2170

 gca agt gta act ggt agc aag agg cag cca aga act cct aag gga aaa     6757
 Ala Ser Val Thr Gly Ser Lys Arg Gln Pro Arg Thr Pro Lys Gly Lys
            2175                2180                2185

 gcc caa ccc cta gaa gac ttg gct ggc ttg aaa gag ctc ttc cag aca     6805
 Ala Gln Pro Leu Glu Asp Leu Ala Gly Leu Lys Glu Leu Phe Gln Thr
        2190                2195                2200

 cca gta tgc act gac aag ccc acg act cac gag aaa act acc aaa ata     6853
 Pro Val Cys Thr Asp Lys Pro Thr Thr His Glu Lys Thr Thr Lys Ile
    2205                2210                2215

 gcc tgc aga tct cca caa cca gac cca gtg ggt acc cca aca atc ttc     6901
 Ala Cys Arg Ser Pro Gln Pro Asp Pro Val Gly Thr Pro Thr Ile Phe
2220                2225                2230                2235

 aag cca cag tcc aag aga agt ctc agg aaa gca gac gta gag gaa gaa     6949
 Lys Pro Gln Ser Lys Arg Ser Leu Arg Lys Ala Asp Val Glu Glu Glu
                2240                2245                2250

 tcc tta gca ctc agg aaa cga aca cca tca gta ggg aaa gct atg gac     6997
 Ser Leu Ala Leu Arg Lys Arg Thr Pro Ser Val Gly Lys Ala Met Asp
            2255                2260                2265

 aca ccc aaa cca gca gga ggt gat gag aaa gac atg aaa gca ttt atg     7045
 Thr Pro Lys Pro Ala Gly Gly Asp Glu Lys Asp Met Lys Ala Phe Met
        2270                2275                2280

 gga act cca gtg cag aaa ttg gac ctg cca gga aat tta cct ggc agc     7093
 Gly Thr Pro Val Gln Lys Leu Asp Leu Pro Gly Asn Leu Pro Gly Ser
    2285                2290                2295

 aaa aga tgg cca caa act cct aag gaa aag gcc cag gct cta gaa gac     7141
 Lys Arg Trp Pro Gln Thr Pro Lys Glu Lys Ala Gln Ala Leu Glu Asp
2300                2305                2310                2315

 ctg gct ggc ttc aaa gag ctc ttc cag aca cca ggc act gac aag ccc     7189
 Leu Ala Gly Phe Lys Glu Leu Phe Gln Thr Pro Gly Thr Asp Lys Pro
                2320                2325                2330

 acg act gat gag aaa act acc aaa ata gcc tgc aaa tct cca caa cca     7237
 Thr Thr Asp Glu Lys Thr Thr Lys Ile Ala Cys Lys Ser Pro Gln Pro
            2335                2340                2345

 gac cca gtg gac acc cca gca agc aca aag caa cgg ccc aag aga aac     7285
 Asp Pro Val Asp Thr Pro Ala Ser Thr Lys Gln Arg Pro Lys Arg Asn
        2350                2355                2360

 ctc agg aaa gca gac gta gag gaa gaa ttt tta gca ctc agg aaa cga     7333
 Leu Arg Lys Ala Asp Val Glu Glu Glu Phe Leu Ala Leu Arg Lys Arg
    2365                2370                2375

 aca cca tca gca ggc aaa gcc atg gac acc cca aaa cca gca gta agt     7381
 Thr Pro Ser Ala Gly Lys Ala Met Asp Thr Pro Lys Pro Ala Val Ser
2380                2385                2390                2395

 gat gag aaa aat atc aac aca ttt gtg gaa act cca gtg cag aaa ctg     7429
 Asp Glu Lys Asn Ile Asn Thr Phe Val Glu Thr Pro Val Gln Lys Leu
                2400                2405                2410

 gac ctg cta gga aat tta cct ggc agc aag aga cag cca cag act cct     7477
 Asp Leu Leu Gly Asn Leu Pro Gly Ser Lys Arg Gln Pro Gln Thr Pro
            2415                2420                2425

 aag gaa aag gct gag gct cta gag gac ctg gtt ggc ttc aaa gaa ctc     7525
 Lys Glu Lys Ala Glu Ala Leu Glu Asp Leu Val Gly Phe Lys Glu Leu
        2430                2435                2440

 ttc cag aca cca ggt cac act gag gaa tca atg act gat gac aaa atc     7573
 Phe Gln Thr Pro Gly His Thr Glu Glu Ser Met Thr Asp Asp Lys Ile
    2445                2450                2455

 aca gaa gta tcc tgt aaa tct cca cag cca gag tca ttc aaa acc tca     7621
 Thr Glu Val Ser Cys Lys Ser Pro Gln Pro Glu Ser Phe Lys Thr Ser
2460                2465                2470                2475

 aga agc tcc aag caa agg ctc aag ata ccc ctg gtg aaa gtg gac atg     7669
 Arg Ser Ser Lys Gln Arg Leu Lys Ile Pro Leu Val Lys Val Asp Met
                2480                2485                2490

 aaa gaa gag ccc cta gca gtc agc aag ctc aca cgg aca tca ggg gag     7717
 Lys Glu Glu Pro Leu Ala Val Ser Lys Leu Thr Arg Thr Ser Gly Glu
            2495                2500                2505

 act acg caa aca cac aca gag cca aca gga gat agt aag agc atc aaa     7765
 Thr Thr Gln Thr His Thr Glu Pro Thr Gly Asp Ser Lys Ser Ile Lys
        2510                2515                2520

 gcg ttt aag gag tct cca aag cag atc ctg gac cca gca gca agt gta     7813
 Ala Phe Lys Glu Ser Pro Lys Gln Ile Leu Asp Pro Ala Ala Ser Val
    2525                2530                2535

 act ggt agc agg agg cag ctg aga act cgt aag gaa aag gcc cgt gct     7861
 Thr Gly Ser Arg Arg Gln Leu Arg Thr Arg Lys Glu Lys Ala Arg Ala
2540                2545                2550                2555

 cta gaa gac ctg gtt gac ttc aaa gag ctc ttc tca gca cca ggt cac     7909
 Leu Glu Asp Leu Val Asp Phe Lys Glu Leu Phe Ser Ala Pro Gly His
                2560                2565                2570

 act gaa gag tca atg act att gac aaa aac aca aaa att ccc tgc aaa     7957
 Thr Glu Glu Ser Met Thr Ile Asp Lys Asn Thr Lys Ile Pro Cys Lys
            2575                2580                2585

 tct ccc cca cca gaa cta aca gac act gcc acg agc aca aag aga tgc     8005
 Ser Pro Pro Pro Glu Leu Thr Asp Thr Ala Thr Ser Thr Lys Arg Cys
        2590                2595                2600

 ccc aag aca cgt ccc agg aaa gaa gta aaa gag gag ctc tca gca gtt     8053
 Pro Lys Thr Arg Pro Arg Lys Glu Val Lys Glu Glu Leu Ser Ala Val
    2605                2610                2615

 gag agg ctc acg caa aca tca ggg caa agc aca cac aca cac aaa gaa     8101
 Glu Arg Leu Thr Gln Thr Ser Gly Gln Ser Thr His Thr His Lys Glu
2620                2625                2630                2635

 cca gca agc ggt gat gag ggc atc aaa gta ttg aag caa cgt gca aag     8149
 Pro Ala Ser Gly Asp Glu Gly Ile Lys Val Leu Lys Gln Arg Ala Lys
                2640                2645                2650

 aag aaa cca aac cca gta gaa gag gaa ccc agc agg aga agg cca aga     8197
 Lys Lys Pro Asn Pro Val Glu Glu Glu Pro Ser Arg Arg Arg Pro Arg
            2655                2660                2665

 gca cct aag gaa aag gcc caa ccc ctg gaa gac ctg gcc ggc ttc aca     8245
 Ala Pro Lys Glu Lys Ala Gln Pro Leu Glu Asp Leu Ala Gly Phe Thr
        2670                2675                2680

 gag ctc tct gaa aca tca ggt cac act cag gaa tca ctg act gct ggc     8293
 Glu Leu Ser Glu Thr Ser Gly His Thr Gln Glu Ser Leu Thr Ala Gly
    2685                2690                2695

 aaa gcc act aaa ata ccc tgc gaa tct ccc cca cta gaa gtg gta gac     8341
 Lys Ala Thr Lys Ile Pro Cys Glu Ser Pro Pro Leu Glu Val Val Asp
2700                2705                2710                2715

 acc aca gca agc aca aag agg cat ctc agg aca cgt gtg cag aag gta     8389
 Thr Thr Ala Ser Thr Lys Arg His Leu Arg Thr Arg Val Gln Lys Val
                2720                2725                2730

 caa gta aaa gaa gag cct tca gca gtc aag ttc aca caa aca tca ggg     8437
 Gln Val Lys Glu Glu Pro Ser Ala Val Lys Phe Thr Gln Thr Ser Gly
            2735                2740                2745

 gaa acc acg gat gca gac aaa gaa cca gca ggt gaa gat aaa ggc atc     8485
 Glu Thr Thr Asp Ala Asp Lys Glu Pro Ala Gly Glu Asp Lys Gly Ile
        2750                2755                2760

 aaa gca ttg aag gaa tct gca aaa cag aca ccg gct cca gca gca agt     8533
 Lys Ala Leu Lys Glu Ser Ala Lys Gln Thr Pro Ala Pro Ala Ala Ser
    2765                2770                2775

 gta act ggc agc agg aga cgg cca aga gca ccc agg gaa agt gcc caa     8581
 Val Thr Gly Ser Arg Arg Arg Pro Arg Ala Pro Arg Glu Ser Ala Gln
2780                2785                2790                2795

 gcc ata gaa gac cta gct ggc ttc aaa gac cca gca gca ggt cac act     8629
 Ala Ile Glu Asp Leu Ala Gly Phe Lys Asp Pro Ala Ala Gly His Thr
                2800                2805                2810

 gaa gaa tca atg act gat gac aaa acc act aaa ata ccc tgc aaa tca     8677
 Glu Glu Ser Met Thr Asp Asp Lys Thr Thr Lys Ile Pro Cys Lys Ser
            2815                2820                2825

 tca cca gaa cta gaa gac acc gca aca agc tca aag aga cgg ccc agg     8725
 Ser Pro Glu Leu Glu Asp Thr Ala Thr Ser Ser Lys Arg Arg Pro Arg
        2830                2835                2840

 aca cgt gcc cag aaa gta gaa gtg aag gag gag ctg tta gca gtt ggc     8773
 Thr Arg Ala Gln Lys Val Glu Val Lys Glu Glu Leu Leu Ala Val Gly
    2845                2850                2855

 aag ctc aca caa acc tca ggg gag acc acg cac acc gac aaa gag ccg     8821
 Lys Leu Thr Gln Thr Ser Gly Glu Thr Thr His Thr Asp Lys Glu Pro
2860                2865                2870                2875

 gta ggt gag ggc aaa ggc acg aaa gca ttt aag caa cct gca aag cgg     8869
 Val Gly Glu Gly Lys Gly Thr Lys Ala Phe Lys Gln Pro Ala Lys Arg
                2880                2885                2890

 aac gtg gac gca gaa gat gta att ggc agc agg aga cag cca aga gca     8917
 Asn Val Asp Ala Glu Asp Val Ile Gly Ser Arg Arg Gln Pro Arg Ala
            2895                2900                2905

 cct aag gaa aag gcc caa ccc ctg gaa gac ctg gcc agc ttc caa gag     8965
 Pro Lys Glu Lys Ala Gln Pro Leu Glu Asp Leu Ala Ser Phe Gln Glu
        2910                2915                2920

 ctc tct caa aca cca ggc cac act gag gaa ctg gca aat ggt gct gct     9013
 Leu Ser Gln Thr Pro Gly His Thr Glu Glu Leu Ala Asn Gly Ala Ala
    2925                2930                2935

 gat agc ttt aca agc gct cca aag caa aca cct gac agt gga aaa cct     9061
 Asp Ser Phe Thr Ser Ala Pro Lys Gln Thr Pro Asp Ser Gly Lys Pro
2940                2945                2950                2955

 cta aaa ata tcc aga aga gtt ctt cgg gcc cct aaa gta gaa ccc gtg     9109
 Leu Lys Ile Ser Arg Arg Val Leu Arg Ala Pro Lys Val Glu Pro Val
                2960                2965                2970

 gga gac gtg gta agc acc aga gac cct gta aaa tca caa agc aaa agc     9157
 Gly Asp Val Val Ser Thr Arg Asp Pro Val Lys Ser Gln Ser Lys Ser
            2975                2980                2985

 aac act tcc ctg ccc cca ctg ccc ttc aag agg gga ggt ggc aaa gat     9205
 Asn Thr Ser Leu Pro Pro Leu Pro Phe Lys Arg Gly Gly Gly Lys Asp
        2990                2995                3000

 gga agc gtc acg gga acc aag agg ctg cgc tgc atg cca gca cca gag     9253
 Gly Ser Val Thr Gly Thr Lys Arg Leu Arg Cys Met Pro Ala Pro Glu
    3005                3010                3015

 gaa att gtg gag gag ctg cca gcc agc aag aag cag agg gtt gct ccc     9301
 Glu Ile Val Glu Glu Leu Pro Ala Ser Lys Lys Gln Arg Val Ala Pro
3020                3025                3030                3035

 agg gca aga ggc aaa tca tcc gaa ccc gtg gtc atc atg aag aga agt     9349
 Arg Ala Arg Gly Lys Ser Ser Glu Pro Val Val Ile Met Lys Arg Ser
                3040                3045                3050

 ttg agg act tct gca aaa aga att gaa cct gcg gaa gag ctg aac agc     9397
 Leu Arg Thr Ser Ala Lys Arg Ile Glu Pro Ala Glu Glu Leu Asn Ser
            3055                3060                3065

 aac gac atg aaa acc aac aaa gag gaa cac aaa tta caa gac tcg gtc     9445
 Asn Asp Met Lys Thr Asn Lys Glu Glu His Lys Leu Gln Asp Ser Val
        3070                3075                3080

 cct gaa aat aag gga ata tcc ctg cgc tcc aga cgc caa gat aag act     9493
 Pro Glu Asn Lys Gly Ile Ser Leu Arg Ser Arg Arg Gln Asp Lys Thr
    3085                3090                3095

 gag gca gaa cag caa ata act gag gtc ttt gta tta gca gaa aga ata     9541
 Glu Ala Glu Gln Gln Ile Thr Glu Val Phe Val Leu Ala Glu Arg Ile
3100                3105                3110                3115

 gaa ata aac aga aat gaa aag aag ccc atg aag acc tcc cca gag atg     9589
 Glu Ile Asn Arg Asn Glu Lys Lys Pro Met Lys Thr Ser Pro Glu Met
                3120                3125                3130

 gac att cag aat cca gat gat gga gcc cgg aaa ccc ata cct aga gac     9637
 Asp Ile Gln Asn Pro Asp Asp Gly Ala Arg Lys Pro Ile Pro Arg Asp
            3135                3140                3145

 aaa gtc act gag aac aaa agg tgc ttg agg tct gct aga cag aat gag     9685
 Lys Val Thr Glu Asn Lys Arg Cys Leu Arg Ser Ala Arg Gln Asn Glu
        3150                3155                3160

 agc tcc cag cct aag gtg gca gag gag agc gga ggg cag aag agt gcg     9733
 Ser Ser Gln Pro Lys Val Ala Glu Glu Ser Gly Gly Gln Lys Ser Ala
    3165                3170                3175

 aag gtt ctc atg cag aat cag aaa ggg aaa gga gaa gca gga aat tca     9781
 Lys Val Leu Met Gln Asn Gln Lys Gly Lys Gly Glu Ala Gly Asn Ser
3180                3185                3190                3195

 gac tcc atg tgc ctg aga tca aga aag aca aaa agc cag cct gca gca     9829
 Asp Ser Met Cys Leu Arg Ser Arg Lys Thr Lys Ser Gln Pro Ala Ala
                3200                3205                3210

 agc act ttg gag agc gaa tct gtg cag aga gta acg cgg agt gtc aag     9877
 Ser Thr Leu Glu Ser Glu Ser Val Gln Arg Val Thr Arg Ser Val Lys
            3215                3220                3225

 agg tgt gca gaa aat cca aag aag gct gag gac aat gtg tgt gtc aag     9925
 Arg Cys Ala Glu Asn Pro Lys Lys Ala Glu Asp Asn Val Cys Val Lys
        3230                3235                3240

 aaa ata aga acc aga agt cat agg gac agt gaa gat att tgacagaaaa      9974
 Lys Ile Arg Thr Arg Ser His Arg Asp Ser Glu Asp Ile 
    3245                3250                3255

 atcgaactgg gaaaaatata ataaagttag ttttgtgata agttctagtg cagtttttgt  10034

 cataaattac aagtgaattc tgtaagtaag gctgtcagtc tgcttaaggg aagaaaactt  10094

 tggatttgct gggtctgaat cggcttcata aactccactg ggagcactgc tgggctcctg  10154

 gactgagaat agttgaacac cgggggcttt gtgaaggagt ctgggccaag gtttgccctc  10214

 agctttgcag aatgaagcct tgaggtctgt caccacccac agccacccta cagcagcctt  10274

 aactgtgaca cttgccacac tgtgtcgtcg tttgtttgcc tatgtcctcc agggcacggt  10334

 ggcaggaaca actatcctcg tctgtcccaa cactgagcag gcactcggta aacacgaatg  10394

 aatggatgag cgcacggatg aatggagctt acaagatctg tctttccaat ggccgggggc  10454

 atttggtccc caaattaagg ctattggaca tctgcacagg acagtcctat ttttgatgtc  10514

 ctttcctttc tgaaaataaa gttttgtgct ttggagaatg actcgtgagc acatctttag  10574

 ggaccaagag tgactttctg taaggagtga ctcgtggctt gccttggtct cttgggaata  10634

 cttttctaac tagggttgct ctcacctgag acattctcca cccgcggaat ctcagggtcc  10694

 caggctgtgg gccatcacga cctcaaactg gctcctaatc tccagctttc ctgtcattga  10754

 aagcttcgga agtttactgg ctctgctccc gcctgttttc tttctgactc tatctggcag  10814

 cccgatgcca cccagtacag gaagtgacac cagtactctg taaagcatca tcatccttgg  10874

 agagactgag cactcagcac cttcagccac gatttcagga tcgcttcctt gtgagccgct  10934

 gcctccgaaa tctcctttga agcccagaca tctttctcca gcttcagact tgtagatata  10994

 actcgttcat cttcatttac tttccacttt gccccctgtc ctctctgtgt tccccaaatc  11054

 agagaatagc ccgccatccc ccagatcacc tgtctggatt cctccccatt cacccacctt  11114

 gccaggtgca ggtgaggatg gtgcaccaga cagggtagct gtcccccaaa atgtgccctg  11174

 tgcgggcagt gccctgtctc cacgtttgtt tccccagtgt ctggcgggga gccaggtgac  11234

 atcataaata cttgctgaat gaatgcagaa atcagcggta ctgacttgta ctatattggc  11294

 tgccatgata gggttctcac agcgtcatcc atgatcgtaa gggagaatga cattctgctt  11354

 gagggaggga atagaaaggg gcagggaggg gacatctgag ggcttcacag ggctgcaaag  11414

 ggtacaggga ttgcaccagg gcagaacagg ggagggtgtt caaggaagag tggctcttag  11474

 cagaggcact ttggaaggtg tgaggcataa atgcttcctt ctacgtaggc caacctcaaa  11534

 actttcagta ggaatgttgc tatgatcaag ttgttctaac actttagact tagtagtaat  11594

 tatgaacctc acatagaaaa atttcatcca gccatatgcc tgtggagtgg aatattctgt  11654

 ttagtagaaa aatcctttag agttcagctc taaccagaaa tcttgctgaa gtatgtcagc  11714

 accttttctc accctggtaa gtacagtatt tcaagagcac gctaagggtg gttttcattt  11774

 tacagggctg ttgatgatgg gttaaaaatg ttcatttaag ggctaccccc gtgtttaata  11834

 gatgaacacc acttctacac aaccctcctt ggtactgggg gagggagaga tctgacaaat  11894

 actgcccatt cccctaggct gactggattt gagaacaaat acccacccat ttccaccatg  11954

 gtatggtaac ttctctgagc ttcagtttcc aagtgaattt ccatgtaata ggacattccc  12014

 attaaataca agctgttttt actttttcgc ctcccagggc ctgtgcgatc tggtccccca  12074

 gcctctcttg ggctttctta cactaactct gtacctacca tctcctgcct cccttaggca  12134

 ggcacctcca accaccacac actccctgct gttttccctg cctggaactt tccctcctgc  12194

 cccaccaaga tcatttcatc cagtcctgag ctcagcttaa gggaggcttc ttgcctgtgg  12254

 gttccctcac ccccatgcct gtcctccagg ctggggcagg ttcttagttt gcctggaatt  12314

 gttctgtacc tctttgtagc acgtagtgtt gtggaaacta agccactaat tgagtttctg  12374

 gctcccctcc tggggttgta agttttgttc attcatgagg gccgactgta tttcctggtt  12434

 actgtatccc agtgaccagc cacaggagat gtccaataaa gtatgtgatg aaatggtctt  12494

 aaaaaaaaaa a                                                       12505




      <210> 19
      <211> 1309
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(981)

      <400> 19
  atg ggc aag tgg gaa ttt ata gcc aac gaa tac ggt ggg gcc tat att      48
  Met Gly Lys Trp Glu Phe Ile Ala Asn Glu Tyr Gly Gly Ala Tyr Ile
    1               5                  10                  15

 tac aag ttt ttc cgg gtc gcc gag aag ggt cac gca cag gat tgc gac       96
 Tyr Lys Phe Phe Arg Val Ala Glu Lys Gly His Ala Gln Asp Cys Asp
              20                  25                  30

 ctc gat tgg aac gcg ctt ccc gaa agg ggc atg cgc aga gag gtc gta      144
 Leu Asp Trp Asn Ala Leu Pro Glu Arg Gly Met Arg Arg Glu Val Val
          35                  40                  45

 gtc gcg tct gag gat gag ctc gct gca tcg ggg ctg ccg agc tgc gat      192
 Val Ala Ser Glu Asp Glu Leu Ala Ala Ser Gly Leu Pro Ser Cys Asp
      50                  55                  60

 gcc gcc gtc aac ctg gcc gga gag aac atc ctc aac cct ctc cga agg      240
 Ala Ala Val Asn Leu Ala Gly Glu Asn Ile Leu Asn Pro Leu Arg Arg
  65                  70                  75                  80

 tca gcc cgg gcc cta aag ctg ata ccc act aga gca cag gga gga cag      288
 Ser Ala Arg Ala Leu Lys Leu Ile Pro Thr Arg Ala Gln Gly Gly Gln
                  85                  90                  95

 tgc ccc act gat gag aac cta tgg aat gaa acc ttc caa aaa gag gta      336
 Cys Pro Thr Asp Glu Asn Leu Trp Asn Glu Thr Phe Gln Lys Glu Val
             100                 105                 110

 atc ggc agc cgc cta gag acc acc caa ttg ctg gct aaa gcc atc acc      384
 Ile Gly Ser Arg Leu Glu Thr Thr Gln Leu Leu Ala Lys Ala Ile Thr
         115                 120                 125

 aaa gcc cca caa ccc ccc aag gcc tgg gtc tta gtc aca ggt gta gct      432
 Lys Ala Pro Gln Pro Pro Lys Ala Trp Val Leu Val Thr Gly Val Ala
     130                 135                 140

 tac tac cag ccc agt ctg act gcg gag tat gat gaa gac agc cca gga      480
 Tyr Tyr Gln Pro Ser Leu Thr Ala Glu Tyr Asp Glu Asp Ser Pro Gly
 145                 150                 155                 160

 ggg gac ttt gac ttt ttc tcc aac ctc gta acc aaa tgg gaa gct gca      528
 Gly Asp Phe Asp Phe Phe Ser Asn Leu Val Thr Lys Trp Glu Ala Ala
                 165                 170                 175

 gcc agg ctt cct gga gat tct aca cgc cag gtg gtg gtg cgc tca ggg      576
 Ala Arg Leu Pro Gly Asp Ser Thr Arg Gln Val Val Val Arg Ser Gly
             180                 185                 190

 gtt gtg ctg ggc cgt ggg ggt ggt gcc atg ggc cac atg ctg ctg ccc      624
 Val Val Leu Gly Arg Gly Gly Gly Ala Met Gly His Met Leu Leu Pro
         195                 200                 205

 ttt cgc ctg ggc ctg ggg ggc ccc atc ggc tca ggc cac caa ttc ttc      672
 Phe Arg Leu Gly Leu Gly Gly Pro Ile Gly Ser Gly His Gln Phe Phe
     210                 215                 220

 ccc tgg ata cac atc ggg gac ctg gca gga atc ctg acc cat gcc ctt      720
 Pro Trp Ile His Ile Gly Asp Leu Ala Gly Ile Leu Thr His Ala Leu
 225                 230                 235                 240

 gaa gca aac cac gtg cac ggg gtc ctg aat gga gtg gct cca tcc tcc      768
 Glu Ala Asn His Val His Gly Val Leu Asn Gly Val Ala Pro Ser Ser
                 245                 250                 255

 gcc act aat gct gag ttt gcc cag acc ttc ggt gct gcc ctg ggc cgc      816
 Ala Thr Asn Ala Glu Phe Ala Gln Thr Phe Gly Ala Ala Leu Gly Arg
             260                 265                 270

 cga gcc ttc atc cct ctc ccc agc gct gtg gtg caa gct gtc ttt ggg      864
 Arg Ala Phe Ile Pro Leu Pro Ser Ala Val Val Gln Ala Val Phe Gly
         275                 280                 285

 cga cag cgt gcc atc atg ctg ctg gag ggc cag aag gtg atc cca cgg      912
 Arg Gln Arg Ala Ile Met Leu Leu Glu Gly Gln Lys Val Ile Pro Arg
     290                 295                 300

 cga aca ctg gcc act ggc tac cag tat tcc ttc cca gag cta ggg gct      960
 Arg Thr Leu Ala Thr Gly Tyr Gln Tyr Ser Phe Pro Glu Leu Gly Ala
 305                 310                 315                 320

 gcc tta aag gaa att gta gcc ta agtaggtcat ggcaagggcc tgaggcctgt     1013
 Ala Leu Lys Glu Ile Val Ala 
                 325

 tcctcacagg cttccaggtt aggcactgtg aataggctca gctcctctag agagctgaag   1073

 ccatctggtt cttagattcc tctcccagtc ctctttccca ttgttctgtt gctccacctt   1133

 attgtctcaa ggccgtaatc tcatcaggtt gggacattaa tcttttcaac tccttgtaag   1193

 atttcccggt ttggtttctc tacatgtcct gcagctgccc cacttctcct ttacgctgtg   1253

 tagagaatgc tctgcagttt aggcaataaa aataaattgt ctcactaaaa aaaaaa       1309




      <210> 20
      <211> 1852
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1788)

      <400> 20
  atg cct gta atc cca gct act cag gag gct gag gca gaa gaa tcg ctc      48
  Met Pro Val Ile Pro Ala Thr Gln Glu Ala Glu Ala Glu Glu Ser Leu
    1               5                  10                  15

 gat cct ggg agg cgg agg ttg cga acc att gga aag ttg gag cca tcc       96
 Asp Pro Gly Arg Arg Arg Leu Arg Thr Ile Gly Lys Leu Glu Pro Ser
              20                  25                  30

 tac gtg atc cgc aag ttt ctg gat gcc cag cgc att cac aac ctg act      144
 Tyr Val Ile Arg Lys Phe Leu Asp Ala Gln Arg Ile His Asn Leu Thr
          35                  40                  45

 gcc tac ctg cag acc ctg cac cga caa tcc ctg gcc aat gcc gac cat      192
 Ala Tyr Leu Gln Thr Leu His Arg Gln Ser Leu Ala Asn Ala Asp His
      50                  55                  60

 acc acc ctg ctc ctc aac tgc tat acc aag ctc aag gac agc tcg aag      240
 Thr Thr Leu Leu Leu Asn Cys Tyr Thr Lys Leu Lys Asp Ser Ser Lys
  65                  70                  75                  80

 ctg gag gag ttc atc aag aaa aag agt gag agt gaa gtc cac ttt gat      288
 Leu Glu Glu Phe Ile Lys Lys Lys Ser Glu Ser Glu Val His Phe Asp
                  85                  90                  95

 gtg gag aca gcc atc aag gtc ctc cgg cag gct ggc tac tac tcc cat      336
 Val Glu Thr Ala Ile Lys Val Leu Arg Gln Ala Gly Tyr Tyr Ser His
             100                 105                 110

 gcc ctg tat ctg gcg gag aac cat gca cat cat gag tgg tac ctg aag      384
 Ala Leu Tyr Leu Ala Glu Asn His Ala His His Glu Trp Tyr Leu Lys
         115                 120                 125

 atc cag cta gaa gac att aag aat tat cag gaa gcc ctt cga tac atc      432
 Ile Gln Leu Glu Asp Ile Lys Asn Tyr Gln Glu Ala Leu Arg Tyr Ile
     130                 135                 140

 ggc aag ctg cct ttt gag cag gca gag agc aac atg aag cgc tac ggc      480
 Gly Lys Leu Pro Phe Glu Gln Ala Glu Ser Asn Met Lys Arg Tyr Gly
 145                 150                 155                 160

 aag atc ctc atg cac cac ata cca gag cag aca act cag ttg ctg aag      528
 Lys Ile Leu Met His His Ile Pro Glu Gln Thr Thr Gln Leu Leu Lys
                 165                 170                 175

 gga ctt tgt act gat tat cgg ccc agc ctc gaa ggc cgc agc gat agg      576
 Gly Leu Cys Thr Asp Tyr Arg Pro Ser Leu Glu Gly Arg Ser Asp Arg
             180                 185                 190

 gag gcc cca ggc tgc agg gcc aac tct gag gag ttc atc ccc atc ttt      624
 Glu Ala Pro Gly Cys Arg Ala Asn Ser Glu Glu Phe Ile Pro Ile Phe
         195                 200                 205

 gcc aat aac ccg cga gag ctg aaa gcc ttc cta gag cac atg agt gaa      672
 Ala Asn Asn Pro Arg Glu Leu Lys Ala Phe Leu Glu His Met Ser Glu
     210                 215                 220

 gtg cag cca gac tca ccc cag ggg atc tac gac aca ctc ctt gag ctg      720
 Val Gln Pro Asp Ser Pro Gln Gly Ile Tyr Asp Thr Leu Leu Glu Leu
 225                 230                 235                 240

 cga ctg cag aac tgg gcc cac gag aag gat cca cag gtc aaa gag aag      768
 Arg Leu Gln Asn Trp Ala His Glu Lys Asp Pro Gln Val Lys Glu Lys
                 245                 250                 255

 ctt cac gca gag gcc att tcc ctg ctg aag agt ggt cgc ttc tgt gac      816
 Leu His Ala Glu Ala Ile Ser Leu Leu Lys Ser Gly Arg Phe Cys Asp
             260                 265                 270

 gtc ttt gac aag gcc ctg gtc ctg tgc cag atg cac gac ttc cag gat      864
 Val Phe Asp Lys Ala Leu Val Leu Cys Gln Met His Asp Phe Gln Asp
         275                 280                 285

 ggt gtc ctt tac ctt tat gag cag ggg aag ctg ttc cag cag atc atg      912
 Gly Val Leu Tyr Leu Tyr Glu Gln Gly Lys Leu Phe Gln Gln Ile Met
     290                 295                 300

 cac tac cac atg cag cac gag cag tac cgg cag gtc atc agc gtg tgt      960
 His Tyr His Met Gln His Glu Gln Tyr Arg Gln Val Ile Ser Val Cys
 305                 310                 315                 320

 gag cgc cat ggg gag cag gac ccc tcc ttg tgg gag cag gcc ctc agc     1008
 Glu Arg His Gly Glu Gln Asp Pro Ser Leu Trp Glu Gln Ala Leu Ser
                 325                 330                 335

 tac ttc gct cgc aag gag gag gac tgc aag gag tat gtg gca gct gtc     1056
 Tyr Phe Ala Arg Lys Glu Glu Asp Cys Lys Glu Tyr Val Ala Ala Val
             340                 345                 350

 ctc aag cat atc gag aac aag aac ctc atg cca cct ctt cta ggt act     1104
 Leu Lys His Ile Glu Asn Lys Asn Leu Met Pro Pro Leu Leu Gly Thr
         355                 360                 365

 tgg gaa gac aga tgg gat gag ctg cgg gtg cgg cgg tac cga gag gag     1152
 Trp Glu Asp Arg Trp Asp Glu Leu Arg Val Arg Arg Tyr Arg Glu Glu
     370                 375                 380

 acc acc cgt atc cgc cag gag atc caa gag ctc aag gcc agt cct aag     1200
 Thr Thr Arg Ile Arg Gln Glu Ile Gln Glu Leu Lys Ala Ser Pro Lys
 385                 390                 395                 400

 att ttc caa aag acc aag tgc agc atc tgt aac agt gcc ttg gag ttg     1248
 Ile Phe Gln Lys Thr Lys Cys Ser Ile Cys Asn Ser Ala Leu Glu Leu
                 405                 410                 415

 ccc tca gtc cac ttc ctg tgt ggc cac tcc ttc cac caa cac tgc ttt     1296
 Pro Ser Val His Phe Leu Cys Gly His Ser Phe His Gln His Cys Phe
             420                 425                 430

 gag agt tac tcg gaa agt gat gct gac tgc ccc acc tgc ctc cct gaa     1344
 Glu Ser Tyr Ser Glu Ser Asp Ala Asp Cys Pro Thr Cys Leu Pro Glu
         435                 440                 445

 aac cgg aag gtc atg gat atg atc cgg gcc cag gaa cag aaa cga gat     1392
 Asn Arg Lys Val Met Asp Met Ile Arg Ala Gln Glu Gln Lys Arg Asp
     450                 455                 460

 ctc cat gat caa ttc cag cat cag ccg cct aag gac gac aag aag aag     1440
 Leu His Asp Gln Phe Gln His Gln Pro Pro Lys Asp Asp Lys Lys Lys
 465                 470                 475                 480

 aag gac gct gga aag tcg gcc aag aaa gac aaa gac cca gtg aac aaa     1488
 Lys Asp Ala Gly Lys Ser Ala Lys Lys Asp Lys Asp Pro Val Asn Lys
                 485                 490                 495

 tcc ggg ggc aag gcc aaa aag aag aag tgg tcc aaa ggc aaa gtt cgg     1536
 Ser Gly Gly Lys Ala Lys Lys Lys Lys Trp Ser Lys Gly Lys Val Arg
             500                 505                 510

 gac aag ctc aat aac tta gtc ttg ttt gac aaa gct acc tat gat aaa     1584
 Asp Lys Leu Asn Asn Leu Val Leu Phe Asp Lys Ala Thr Tyr Asp Lys
         515                 520                 525

 ctc tgt aag gaa gtt ccc aac tat aaa ctt ata acc cca gct gtg gtc     1632
 Leu Cys Lys Glu Val Pro Asn Tyr Lys Leu Ile Thr Pro Ala Val Val
     530                 535                 540

 tct gag aga ctg aag att cga ggc tcc ctg gcc agg gca gcc ctt cag     1680
 Ser Glu Arg Leu Lys Ile Arg Gly Ser Leu Ala Arg Ala Ala Leu Gln
 545                 550                 555                 560

 gag ctc ctt agt aaa gga ctt atc aaa ctg gtt tca aag cac aga gct     1728
 Glu Leu Leu Ser Lys Gly Leu Ile Lys Leu Val Ser Lys His Arg Ala
                 565                 570                 575

 caa gta att tac acc aga aat acc aag ggt gga gat gct cca gct gct     1776
 Gln Val Ile Tyr Thr Arg Asn Thr Lys Gly Gly Asp Ala Pro Ala Ala
             580                 585                 590

 ggt gaa gat gca tga ataggtccaa ccagctgtac atttggaaaa ataaaacttt     1831
 Gly Glu Asp Ala 
         595

 attaaatcaa aaaaaaaaaa a                                             1852




      <210> 21
      <211> 1584
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (14)..(904)

      <400> 21
 gcacgaggtc aag   atg gcg gga gca gct acc cag gct tcc ctg gag tcg      49
                  Met Ala Gly Ala Ala Thr Gln Ala Ser Leu Glu Ser
                    1               5                  10

 gcc cca cgg atc atg cgg ctg gtg gcc gaa tgc agc cgc tcc agg gcc       97
 Ala Pro Arg Ile Met Arg Leu Val Ala Glu Cys Ser Arg Ser Arg Ala
          15                  20                  25

 cgg gca ggc gag ctg tgg ctg ccg cat ggg aca gtg gcc act cct gtg      145
 Arg Ala Gly Glu Leu Trp Leu Pro His Gly Thr Val Ala Thr Pro Val
      30                  35                  40

 ttc atg cca gtg ggc acg cag gcc acc atg aag ggc atc acg acc gaa      193
 Phe Met Pro Val Gly Thr Gln Ala Thr Met Lys Gly Ile Thr Thr Glu
  45                  50                  55                  60

 cag ctg gac gct ctg ggt tgc cgc atc tgc ctg ggc aat acc tac cat      241
 Gln Leu Asp Ala Leu Gly Cys Arg Ile Cys Leu Gly Asn Thr Tyr His
                  65                  70                  75

 ctg ggt cta agg ccg gga ccc gag ctg atc cag aaa gcc aac ggt ctc      289
 Leu Gly Leu Arg Pro Gly Pro Glu Leu Ile Gln Lys Ala Asn Gly Leu
              80                  85                  90

 cac ggc ttc atg aat tgg cct cat aat ctg cta acg gac agc ggc ggt      337
 His Gly Phe Met Asn Trp Pro His Asn Leu Leu Thr Asp Ser Gly Gly
          95                 100                 105

 ttc cag atg gtg tcg ctg gtg tct ctg tcc gag gtg acg gag gag ggc      385
 Phe Gln Met Val Ser Leu Val Ser Leu Ser Glu Val Thr Glu Glu Gly
     110                 115                 120

 gtc cgc ttc cgc tcc ccc tac gac ggc aat gag acc ctg ctg agc ccg      433
 Val Arg Phe Arg Ser Pro Tyr Asp Gly Asn Glu Thr Leu Leu Ser Pro
 125                 130                 135                 140

 gag aaa tcc gtg cag atc cag aat gcg ctg ggc tcg gac atc atc atg      481
 Glu Lys Ser Val Gln Ile Gln Asn Ala Leu Gly Ser Asp Ile Ile Met
                 145                 150                 155

 cag ctg gac gac gtg gtt agc agt act gtg act ggg cca cgt gtg gag      529
 Gln Leu Asp Asp Val Val Ser Ser Thr Val Thr Gly Pro Arg Val Glu
             160                 165                 170

 gag gcc atg tac agg tca atc cgc tgg ctg gac cgg tgc att gca gcc      577
 Glu Ala Met Tyr Arg Ser Ile Arg Trp Leu Asp Arg Cys Ile Ala Ala
         175                 180                 185

 cat cag cgg ccg gac aag cag aac ctc ttc gcc att atc cag ggt ggg      625
 His Gln Arg Pro Asp Lys Gln Asn Leu Phe Ala Ile Ile Gln Gly Gly
     190                 195                 200

 ctg gac gca gat ctc cgg gcc acc tgc ctt gaa gag atg acc aag cga      673
 Leu Asp Ala Asp Leu Arg Ala Thr Cys Leu Glu Glu Met Thr Lys Arg
 205                 210                 215                 220

 gac gtg cct ggc ttc gcc atc ggg ggc ctg agc ggg ggt gag agc aag      721
 Asp Val Pro Gly Phe Ala Ile Gly Gly Leu Ser Gly Gly Glu Ser Lys
                 225                 230                 235

 tcg cag ttc tgg cgg atg gtg gcg ctg agc acc tct cgg ctg ccg aag      769
 Ser Gln Phe Trp Arg Met Val Ala Leu Ser Thr Ser Arg Leu Pro Lys
             240                 245                 250

 gac aag ccc cga tat ctg atg ggg gtt ggg tat gtt gtg gat agg gaa      817
 Asp Lys Pro Arg Tyr Leu Met Gly Val Gly Tyr Val Val Asp Arg Glu
         255                 260                 265

 gcc aga gcc cta cct gtg gga agt gga ttc ctg ggg acc ccc tac cct      865
 Ala Arg Ala Leu Pro Val Gly Ser Gly Phe Leu Gly Thr Pro Tyr Pro
     270                 275                 280

 gct tgg gga ggt ggc att tgg ggg aaa cgg aca cag gtc tgatctgagg       914
 Ala Trp Gly Gly Gly Ile Trp Gly Lys Arg Thr Gln Val 
 285                 290                 295

 agactaggaa gacatggctg tcccttgggg gccattctga gggaatatgg cccagtctgg    974

 ggcagtgtga gggttgggag gggccctggg aagcccctga ggttctctgc cccctcccgt   1034

 catggctgca accccagcta tgccactgat ctggtagtct gcgtggctct tggatgtgac   1094

 atgttcgact gcgtcttccc cacacggaca gcgcgctttg gctctgccct ggtgcccact   1154

 gggaacctgc agttgaggaa gaaggtgttt gagaaggact tcggccccat agacccggag   1214

 tgcacctgcc ccacgtgcca aaagcacagc cgcgccttcc tgcacgcact gctgcacagt   1274

 gacaacacgg ccgcgctgca ccacctcacg gtccacaaca tcgcctacca gctgcagctc   1334

 atgagcgccg tccgcaccag catcgtggag aagcgcttcc cggacttcgt gcgggacttc   1394

 atgggcgcca tgtacgggga tcccaccctc tgtcccacct gggccactga cgctctggcc   1454

 tctgtgggaa tcacactggg ctgacctggc attgggagag ggagggagga aggaagggag   1514

 ggaggggctg gaagatactg aaggattcct ttttgaaagg ttttttttat tgtaacttaa   1574

 aaaaaaaaaa                                                          1584




      <210> 22
      <211> 1643
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (600)..(1067)

      <400> 22
 ctttgtgtca atggatttat cccactgaac aatttgaatg aagacaatgt ggaatggctt     60

 tgagatacag ttcagttttt attaggcatc aatttgtatt ggtgtgaact tttcaaaatg    120

 taaatcatat atgcagtttc tttggtatga cctgtgttaa ctcagattca gagaatttat    180

 aatgtatttt tttaataaca taagaaaact tttctgatat tcctctagtt ttggattgcc    240

 aaaatattca cagtagagga aaactgagaa aacgtaggaa accattcttt atacttgcat    300

 gtaaacatct tccagcaaca atcatttatt gttaaacctg gaaaaagcca ttacacagga    360

 aacctctgtt gatataagcg atgatgggaa aggctattta gccactctgc atatttaatg    420

 ctcatgatca acatctgctt cctatagctg ggatgatatg ggggaagata tttatccctt    480

 ctggggatca tatataaatg atgatagtag tacctacagt atagtgctgt tagaattaca    540

 tgagttagat gtggaggtca gagtggaagc aggtgtgaga gggtcccgca gaagaaaac     599                                                                 
 atg gct gcc aaa gtg ttt gag tcc atc ggc aag ttt ggc ctg gcc tta      647
 Met Ala Ala Lys Val Phe Glu Ser Ile Gly Lys Phe Gly Leu Ala Leu
   1               5                  10                  15

 gct gtt gca gga ggc atg gtg aac tct gcc tta tgt aat gtg gat gct      695
 Ala Val Ala Gly Gly Met Val Asn Ser Ala Leu Cys Asn Val Asp Ala
              20                  25                  30

 ggg cac aga gct gcc atc ttt gac caa ttc cgt gga gta cag aac att      743
 Gly His Arg Ala Ala Ile Phe Asp Gln Phe Arg Gly Val Gln Asn Ile
          35                  40                  45

 gtg gta ggg gaa ggg act cac ttt ctc atc cca tgt gta caa aaa cca      791
 Val Val Gly Glu Gly Thr His Phe Leu Ile Pro Cys Val Gln Lys Pro
      50                  55                  60

 att atc ttt gac tgc tgt tct caa cca cgt agt gcg cca gtc atc act      839
 Ile Ile Phe Asp Cys Cys Ser Gln Pro Arg Ser Ala Pro Val Ile Thr
  65                  70                  75                  80

 ggt agc aaa gat tta cag aat gtc aac atc aca ctg tgc atc ctc ttc      887
 Gly Ser Lys Asp Leu Gln Asn Val Asn Ile Thr Leu Cys Ile Leu Phe
                  85                  90                  95

 cgg ccc atc act agc cag ctt cct cgc atc ttc acc agc att gga gag      935
 Arg Pro Ile Thr Ser Gln Leu Pro Arg Ile Phe Thr Ser Ile Gly Glu
             100                 105                 110

 gac tac gat gag tgt gtg ctg ccg ttc att acc acg gag atc ctc aag      983
 Asp Tyr Asp Glu Cys Val Leu Pro Phe Ile Thr Thr Glu Ile Leu Lys
         115                 120                 125

 tca ctg gtg gct cgc ttt gat gct gga gaa cta atc acc cag agg gag     1031
 Ser Leu Val Ala Arg Phe Asp Ala Gly Glu Leu Ile Thr Gln Arg Glu
     130                 135                 140

 ctg gtc tcc agc cag gtg agc aac aac ctt atg gag tgag cagccacctt     1081
 Leu Val Ser Ser Gln Val Ser Asn Asn Leu Met Glu 
 145                 150                 155

 tgggctcatt ctggacgacg tgtctttgac acatctgacc ttcttgaagg agttaacaga   1141

 caggtggccc cccaggaagc agagagcgcc agatttgtgg tggaaaaggc ggccatcatc   1201

 tctgctgagg gtgactccaa ggcagctgag ctgatcgcca actcactggc cactgcaggg   1261

 gacggccaga gcgagctgtg caagctggaa gctgcagaag acattgcata ccagctctca   1321

 tgctctcgga acatcacctg cctgccggca gggcagtccg tgctcctcca gctgccctag   1381

 tgaggcccca gcctacctgc acctccgtga ggcaactggg ccacagcccc gatgattcgt   1441

 aacaccacct ttcgccctca ccccagaaat cactgaaatt tcatgattgg cttaaagtga   1501

 aggaagtaaa ggtaaaatca cttcagatct ctaaaaaaca aagaattaca tgagttagta   1561

 catgaaaaaa ttatgggaaa ctacatgaaa tatactgtta cgttcaataa acattagctt   1621

 ctgtatataa taaaaaaaaa aa                                            1643




      <210> 23
      <211> 1744
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (85)..(1545)

      <400> 23
 ggccggaatt cccgggtcga cgatgtcgtc ctgttccggg cggggttggg gcggaagggc     60

 tgccaggcgc ccagctgtgc ccag   atg gat ggg aca gag acc cgg cag cgg     111
                              Met Asp Gly Thr Glu Thr Arg Gln Arg
                                1               5

 agg ctg gac agc tgt ggc aag cca ggg gag ctg ggg ctt cct cac ccc      159
 Arg Leu Asp Ser Cys Gly Lys Pro Gly Glu Leu Gly Leu Pro His Pro
  10                  15                  20                  25

 ctc agc aca gga gga ctc cct gta gcc tca gaa gat gga gct ctc agg      207
 Leu Ser Thr Gly Gly Leu Pro Val Ala Ser Glu Asp Gly Ala Leu Arg
                  30                  35                  40

 gcc cct gag agc caa agc gtg acc ccc aag cca ctg gag act gag cct      255
 Ala Pro Glu Ser Gln Ser Val Thr Pro Lys Pro Leu Glu Thr Glu Pro
              45                  50                  55

 agc agg gag acc gcc tgg tcc ata ggc ctt cag gtg acc gtg ccc ttc      303
 Ser Arg Glu Thr Ala Trp Ser Ile Gly Leu Gln Val Thr Val Pro Phe
          60                  65                  70

 atg ttt gca ggc ctg gga ctg tcc tgg gcc ggc atg ctt ctg gac tat      351
 Met Phe Ala Gly Leu Gly Leu Ser Trp Ala Gly Met Leu Leu Asp Tyr
      75                  80                  85

 ttc cag cac tgg cct gtg ttt gtg gag gtg aaa gac ctt ttg aca ttg      399
 Phe Gln His Trp Pro Val Phe Val Glu Val Lys Asp Leu Leu Thr Leu
  90                  95                 100                 105

 gtg ccg ccc ctg gtg ggc ctg aag ggg aac ctg gag atg aca ctg gca      447
 Val Pro Pro Leu Val Gly Leu Lys Gly Asn Leu Glu Met Thr Leu Ala
                 110                 115                 120

 tcc aga ctc tcc aca gct gcc aac act gga caa att gat gac ccc cag      495
 Ser Arg Leu Ser Thr Ala Ala Asn Thr Gly Gln Ile Asp Asp Pro Gln
             125                 130                 135

 gag cag cac aga gtc atc agc agc aac ctg gcc ctc atc cag gtg cag      543
 Glu Gln His Arg Val Ile Ser Ser Asn Leu Ala Leu Ile Gln Val Gln
         140                 145                 150

 gcc act gtc gtg ggg ctc ttg gct gct gtg gct gcg ctg ctg ttg ggc      591
 Ala Thr Val Val Gly Leu Leu Ala Ala Val Ala Ala Leu Leu Leu Gly
     155                 160                 165

 gtg gtg tct cga gag gaa gtg gat gtc gcc aag gtg gag ttg ctg tgt      639
 Val Val Ser Arg Glu Glu Val Asp Val Ala Lys Val Glu Leu Leu Cys
 170                 175                 180                 185

 gcc agc agt gtc ctc act gcc ttc ctt gca gcc ttt gcc ctg ggg gtg      687
 Ala Ser Ser Val Leu Thr Ala Phe Leu Ala Ala Phe Ala Leu Gly Val
                 190                 195                 200

 ctg atg gtc tgt ata gtg att ggt gct cga aag ctc ggg gtc aac cca      735
 Leu Met Val Cys Ile Val Ile Gly Ala Arg Lys Leu Gly Val Asn Pro
             205                 210                 215

 gac aac att gcc acg ccc att gca gcc agc ctg gga gac ctc atc aca      783
 Asp Asn Ile Ala Thr Pro Ile Ala Ala Ser Leu Gly Asp Leu Ile Thr
         220                 225                 230

 ctg tcc att ctg gct ttg gtt agc agc ttc ttc tac aga cac aaa gat      831
 Leu Ser Ile Leu Ala Leu Val Ser Ser Phe Phe Tyr Arg His Lys Asp
     235                 240                 245

 agt cgg tat ctg acg ccg ctg gtc tgc ctc agc ttt gcg gct ctg acc      879
 Ser Arg Tyr Leu Thr Pro Leu Val Cys Leu Ser Phe Ala Ala Leu Thr
 250                 255                 260                 265

 cca gtg tgg gtc ctc att gcc aag cag agc cca ccc atc gtg aag atc      927
 Pro Val Trp Val Leu Ile Ala Lys Gln Ser Pro Pro Ile Val Lys Ile
                 270                 275                 280

 ctg aag ttt ggc tgg ttc cca atc atc ctg gcc atg gtc atc agc agt      975
 Leu Lys Phe Gly Trp Phe Pro Ile Ile Leu Ala Met Val Ile Ser Ser
             285                 290                 295

 ttc gga gga ctc atc ttg agc aaa acc gtt tct aaa cag cag tac aaa     1023
 Phe Gly Gly Leu Ile Leu Ser Lys Thr Val Ser Lys Gln Gln Tyr Lys
         300                 305                 310

 ggc atg gcg ata ttt acc ccc gtc ata tgt ggt gtt ggt ggc aat ctg     1071
 Gly Met Ala Ile Phe Thr Pro Val Ile Cys Gly Val Gly Gly Asn Leu
     315                 320                 325

 gtg gcc att cag acc agc cga atc tca acc tac ctg cac atg tgg agt     1119
 Val Ala Ile Gln Thr Ser Arg Ile Ser Thr Tyr Leu His Met Trp Ser
 330                 335                 340                 345

 gca cct ggc gtc ctg ccc ctc cag atg aag aaa ttc tgg ccc aac ccg     1167
 Ala Pro Gly Val Leu Pro Leu Gln Met Lys Lys Phe Trp Pro Asn Pro
                 350                 355                 360

 tgt tct act ttc tgc acg tca gaa atc aat tcc atg tca gct cga gtc     1215
 Cys Ser Thr Phe Cys Thr Ser Glu Ile Asn Ser Met Ser Ala Arg Val
             365                 370                 375

 ctg ctc ttg ctg gtg gtc cca ggc cat ctg att ttc ttc tac atc atc     1263
 Leu Leu Leu Leu Val Val Pro Gly His Leu Ile Phe Phe Tyr Ile Ile
         380                 385                 390

 tac ctg gtg gag ggt cag tca gtc ata aac agc cag acc ttt gtg gtg     1311
 Tyr Leu Val Glu Gly Gln Ser Val Ile Asn Ser Gln Thr Phe Val Val
     395                 400                 405

 ctc tac ctg ctg gca ggc ctg atc cag gtg aca atc ctg ctg tac ctg     1359
 Leu Tyr Leu Leu Ala Gly Leu Ile Gln Val Thr Ile Leu Leu Tyr Leu
 410                 415                 420                 425

 gca gaa gtg atg gtt cgg ctg act tgg cac cag gcc ctg gat cct gac     1407
 Ala Glu Val Met Val Arg Leu Thr Trp His Gln Ala Leu Asp Pro Asp
                 430                 435                 440

 aac cac tgc atc ccc tac ctt aca ggg ctg ggg gac ctg ctc ggt act     1455
 Asn His Cys Ile Pro Tyr Leu Thr Gly Leu Gly Asp Leu Leu Gly Thr
             445                 450                 455

 ggc ctc ctg gca ctc tgc ttt ttc act gac tgg cta ctg aag agc aag     1503
 Gly Leu Leu Ala Leu Cys Phe Phe Thr Asp Trp Leu Leu Lys Ser Lys
         460                 465                 470

 gca gag ctg ggt ggc atc tca gaa ctg gca tct gga cct ccc taactgg     1552
 Ala Glu Leu Gly Gly Ile Ser Glu Leu Ala Ser Gly Pro Pro 
     475                 480                 485

 gccccgctgg tcccatttgc tcattagaat ttcctctcac atcagtggga tacagaattc   1612

 agtttctccc ttgccaggtc cttgggatgg ttgacccctg cctctgcagt agccttttgt   1672

 gagtctgcta aggtagctct cacacacctc ggctctgggg ttgatacctg agcctgcaat   1732

 agagccctga aa                                                       1744




      <210> 24
      <211> 2489
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (876)..(2396)

      <400> 24
 ctactgtgtt ggcggactgg cgggactggg tgctgcgtga gtctctgagc gcagtgcggg     60

 cggctggcgc ccctcccccg gcagcgtgcg gcggctggct gtgcggctgg cggcggcgtg    120

 cggcagctca ctcagcccgg tcggcgacgc cggaacctct gcttgggaag gggacggtgc    180

 ggtcccactg ggggcaatgg gtgcgctagc ggcggccggc ttgttgtctt ccggcggctg    240

 cctctcccgt gcggaagtcg ccagatgggt gatgcgccgg gcatttggtg gtcgtttgat    300

 gtggaatgtg gatgagtggt gggtgggtgg gggtggttgg tacggtcggg cggtggtacg    360

 gtgttgtcga ttcagcttca tcccgtgagg aggtagattg ggcatgtgca tgggctccgt    420

 gttgaagatc ctcaaaacca acagcacaca gcttccagcg catgctcctt tccccaagac    480

 cctgtggggg aacccgccgc cagcgcggag ccaccgtgac tcgtagcctg acttccgttt    540

 ccgggggcgg cttccggcgg cgtgaccgca agaggccaat ggagtgtggg agctgaaagg    600

 gtcttcgctg gcggccggta actggcggcg gttgggaacg gccgagtgtg gctcttctgg    660

 tgtttcagct tggggagaga ggggtggcct tcttcttgca gttgaggccg gcgccgagcc    720

 ggacttcagc cggatctcgt ggcggagccc atcttgctcc ctctcccagg cctttacccg    780

 ctccctagga ttcccgggcc ctgtaggtgg gagttgggag acgacagtac tgcttttaaa    840

 gagacagtgt tagggatctt ggaagcacag ccaac   atg tgt gac att gaa gaa     893
                                          Met Cys Asp Ile Glu Glu
                                            1               5

 gcc act aac caa ctc cta gat gtg aac ctt cat gag aac cag aag tct      941
 Ala Thr Asn Gln Leu Leu Asp Val Asn Leu His Glu Asn Gln Lys Ser
              10                  15                  20

 gta caa gtg aca gaa agt gac ctc gga agt gaa tct gag ctt cta gtc      989
 Val Gln Val Thr Glu Ser Asp Leu Gly Ser Glu Ser Glu Leu Leu Val
          25                  30                  35

 act att gga gcc act gta cct act ggc ttt gag caa aca gct gca gat     1037
 Thr Ile Gly Ala Thr Val Pro Thr Gly Phe Glu Gln Thr Ala Ala Asp
      40                  45                  50

 gaa gtc aga gag aaa ctt ggg tca tca tgc aaa atc agc aga gac cgt     1085
 Glu Val Arg Glu Lys Leu Gly Ser Ser Cys Lys Ile Ser Arg Asp Arg
  55                  60                  65                  70

 ggc aag ata tat ttt gtc att tca gtg gaa agt ctg gca cag gtt cat     1133
 Gly Lys Ile Tyr Phe Val Ile Ser Val Glu Ser Leu Ala Gln Val His
                  75                  80                  85

 tgt ctg aga tca gtt gat aac tta ttt gtg gtg gtt cag gag ttt caa     1181
 Cys Leu Arg Ser Val Asp Asn Leu Phe Val Val Val Gln Glu Phe Gln
              90                  95                 100

 gat tac cag ttc aaa caa aca aag gaa gaa gtt cta aag gat ttt gaa     1229
 Asp Tyr Gln Phe Lys Gln Thr Lys Glu Glu Val Leu Lys Asp Phe Glu
         105                 110                 115

 gac ttg gct gga aaa ctc cca tgg tca aac ccc tta aaa gtg tgg aaa     1277
 Asp Leu Ala Gly Lys Leu Pro Trp Ser Asn Pro Leu Lys Val Trp Lys
     120                 125                 130

 att aat gcc agt ttt aaa aag aaa aaa gca aag cgc aaa aag ata aat     1325
 Ile Asn Ala Ser Phe Lys Lys Lys Lys Ala Lys Arg Lys Lys Ile Asn
 135                 140                 145                 150

 cag aat tca agt aaa gag aag att aat aat gga caa gaa gtc aaa atc     1373
 Gln Asn Ser Ser Lys Glu Lys Ile Asn Asn Gly Gln Glu Val Lys Ile
                 155                 160                 165

 gat cag aga aat gtt aaa aaa gag ttc act agc cat gct tta gat tct     1421
 Asp Gln Arg Asn Val Lys Lys Glu Phe Thr Ser His Ala Leu Asp Ser
             170                 175                 180

 cat atc tta gat tat tat gaa aat cca gcc atc aaa gag gat gta tca     1469
 His Ile Leu Asp Tyr Tyr Glu Asn Pro Ala Ile Lys Glu Asp Val Ser
         185                 190                 195

 aca tta ata ggt gat gat ttg gca tct tgc aaa gat gag act gat gaa     1517
 Thr Leu Ile Gly Asp Asp Leu Ala Ser Cys Lys Asp Glu Thr Asp Glu
     200                 205                 210

 agc tca aaa gaa gaa act gag cct caa gtg ctg aag ttt aga gtc aca     1565
 Ser Ser Lys Glu Glu Thr Glu Pro Gln Val Leu Lys Phe Arg Val Thr
 215                 220                 225                 230

 tgc aac agg gca gga gag aaa cat tgc ttt acc tca aat gag gct gca     1613
 Cys Asn Arg Ala Gly Glu Lys His Cys Phe Thr Ser Asn Glu Ala Ala
                 235                 240                 245

 aga gat ttt ggg ggt gct gtt caa gat tat ttt aag tgg aag gcc gac     1661
 Arg Asp Phe Gly Gly Ala Val Gln Asp Tyr Phe Lys Trp Lys Ala Asp
             250                 255                 260

 atg acc aac ttt gat gtg gag gtt ctt ttg aac atc cat gat aat gaa     1709
 Met Thr Asn Phe Asp Val Glu Val Leu Leu Asn Ile His Asp Asn Glu
         265                 270                 275

 gtc att gtg ggc att gca ttg act gaa gag agt ctc cac cga aga aat     1757
 Val Ile Val Gly Ile Ala Leu Thr Glu Glu Ser Leu His Arg Arg Asn
     280                 285                 290

 ata aca cat ttt gga cct aca act ctt aga tca act ctt gcc tat ggg     1805
 Ile Thr His Phe Gly Pro Thr Thr Leu Arg Ser Thr Leu Ala Tyr Gly
 295                 300                 305                 310

 atg ctc agg ctc tgt gat cct cta cct tat gat ata ata gtc gat cca     1853
 Met Leu Arg Leu Cys Asp Pro Leu Pro Tyr Asp Ile Ile Val Asp Pro
                 315                 320                 325

 atg tgt gga act ggg gca ata cca ata gag ggg gcc act gaa tgg tct     1901
 Met Cys Gly Thr Gly Ala Ile Pro Ile Glu Gly Ala Thr Glu Trp Ser
             330                 335                 340

 gac tgt ttc cat att gct ggt gat aat aat cca ctg gct gtg aat aga     1949
 Asp Cys Phe His Ile Ala Gly Asp Asn Asn Pro Leu Ala Val Asn Arg
         345                 350                 355

 gca gca aat aac att gca tct tta ttg acc aag agc caa att aaa gaa     1997
 Ala Ala Asn Asn Ile Ala Ser Leu Leu Thr Lys Ser Gln Ile Lys Glu
     360                 365                 370

 ggc aaa ccc tcc tgg ggc ttg ccc ata gat gct gtt cag tgg gat atc     2045
 Gly Lys Pro Ser Trp Gly Leu Pro Ile Asp Ala Val Gln Trp Asp Ile
 375                 380                 385                 390

 tgc aat ctg cca ttg aga act ggc tct gtg gat att att gta aca gat     2093
 Cys Asn Leu Pro Leu Arg Thr Gly Ser Val Asp Ile Ile Val Thr Asp
                 395                 400                 405

 ttg cca ttt gga aaa agg atg gga tcc aag aag aga aac tgg aac ctt     2141
 Leu Pro Phe Gly Lys Arg Met Gly Ser Lys Lys Arg Asn Trp Asn Leu
             410                 415                 420

 tat cca gct tgc cta cgg gag atg agc cgt gtc tgc aca cct acc aca     2189
 Tyr Pro Ala Cys Leu Arg Glu Met Ser Arg Val Cys Thr Pro Thr Thr
         425                 430                 435

 ggc cga gct gta cta ctt act caa gac aca aaa tgc ttt acc aag gcg     2237
 Gly Arg Ala Val Leu Leu Thr Gln Asp Thr Lys Cys Phe Thr Lys Ala
     440                 445                 450

 tta tct gga atg cga cac gta tgg cga aag gtg gat aca gtc tgg gtg     2285
 Leu Ser Gly Met Arg His Val Trp Arg Lys Val Asp Thr Val Trp Val
 455                 460                 465                 470

 aac gtt ggt ggt ctt cgt gct gca gtt tac gtt ctg ata cgt aca cct     2333
 Asn Val Gly Gly Leu Arg Ala Ala Val Tyr Val Leu Ile Arg Thr Pro
                 475                 480                 485

 caa gct ttt gtt cat cct tca gaa caa gac gga gaa aga gga act ctt     2381
 Gln Ala Phe Val His Pro Ser Glu Gln Asp Gly Glu Arg Gly Thr Leu
             490                 495                 500

 tgg caa tgc aaa gaa tgaagatgac taatagtact tgtacttccc accactggaa     2436
 Trp Gln Cys Lys Glu 
         505

 atgttagcat aaaagaactt ggagaggaaa aaagtattaa caaaaaaaaa aaa          2489




      <210> 25
      <211> 1120
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (104)..(901)

      <400> 25
 gctaggtttg caaagctgtg ggctgagcac tcaggcaatc acactctcag aaactgcggc     60

 ggctctggac tgcagcctcc caaggctcca tgccagacaa agc  atg cgt gtc aca     115
                                                  Met Arg Val Thr
                                                    1

 ctt gct aca ata gcc tgg atg gtt tct ttt gtc tcc aat tat tca cac      163
 Leu Ala Thr Ile Ala Trp Met Val Ser Phe Val Ser Asn Tyr Ser His
   5                  10                  15                  20

 aca gca aat att ttg cca gat atc gaa aat gaa gat ttc atc aaa gac      211
 Thr Ala Asn Ile Leu Pro Asp Ile Glu Asn Glu Asp Phe Ile Lys Asp
                  25                  30                  35

 tgc gtt cga atc cat aac aag ttc cga tca gag gtg aaa cca aca gcc      259
 Cys Val Arg Ile His Asn Lys Phe Arg Ser Glu Val Lys Pro Thr Ala
              40                  45                  50

 agt gat atg cta tac atg act tgg gac cca gca cta gcc caa att gca      307
 Ser Asp Met Leu Tyr Met Thr Trp Asp Pro Ala Leu Ala Gln Ile Ala
          55                  60                  65

 aaa gca tgg gcc agc aat tgc cag ttt tca cat aat aca cgg ctg aag      355
 Lys Ala Trp Ala Ser Asn Cys Gln Phe Ser His Asn Thr Arg Leu Lys
      70                  75                  80

 cca ccc cac aag ctg cac cca aac ttc act tca ctg gga gag aac atc      403
 Pro Pro His Lys Leu His Pro Asn Phe Thr Ser Leu Gly Glu Asn Ile
  85                  90                  95                 100

 tgg act ggg tct gtg ccc att ttt tct gtg tct tcc gcc atc aca aac      451
 Trp Thr Gly Ser Val Pro Ile Phe Ser Val Ser Ser Ala Ile Thr Asn
                 105                 110                 115

 tgg tat gac gaa atc cag gac tat gac ttc aag act cgg ata tgc aaa      499
 Trp Tyr Asp Glu Ile Gln Asp Tyr Asp Phe Lys Thr Arg Ile Cys Lys
             120                 125                 130

 aaa gtc tgt ggc cac tac act cag gtt gtt tgg gca gat agt tac aaa      547
 Lys Val Cys Gly His Tyr Thr Gln Val Val Trp Ala Asp Ser Tyr Lys
         135                 140                 145

 gtt ggc tgc gca gtt caa ttt tgc cct aaa gtt tct ggc ttt gac gct      595
 Val Gly Cys Ala Val Gln Phe Cys Pro Lys Val Ser Gly Phe Asp Ala
     150                 155                 160

 ctt tcc aat gga gca cat ttt ata tgc aac tac gga cca gga ggg aat      643
 Leu Ser Asn Gly Ala His Phe Ile Cys Asn Tyr Gly Pro Gly Gly Asn
 165                 170                 175                 180

 tac cca act tgg cca tat aag aga gga gcc acc tgc agt gcc tgc ccc      691
 Tyr Pro Thr Trp Pro Tyr Lys Arg Gly Ala Thr Cys Ser Ala Cys Pro
                 185                 190                 195

 aat aat gac aag tgt ttg gac aat ctc tgt gtt aac cga cag cga gac      739
 Asn Asn Asp Lys Cys Leu Asp Asn Leu Cys Val Asn Arg Gln Arg Asp
             200                 205                 210

 caa gtc aaa cgt tac tac tct gtt gta tat cca ggc tgg ccc ata tat      787
 Gln Val Lys Arg Tyr Tyr Ser Val Val Tyr Pro Gly Trp Pro Ile Tyr
         215                 220                 225

 cca cgt aac aga tac act tct ctc ttt ctc att gtt aat tca gta att      835
 Pro Arg Asn Arg Tyr Thr Ser Leu Phe Leu Ile Val Asn Ser Val Ile
     230                 235                 240

 cta ata ctg tct gtt ata att acc att ttg gta cag cac aag tac cct      883
 Leu Ile Leu Ser Val Ile Ile Thr Ile Leu Val Gln His Lys Tyr Pro
 245                 250                 255                 260

 aat tta gtt ctt ttg gac taatac aattcaggaa agaaaaaacc caaaaaccaa      937
 Asn Leu Val Leu Leu Asp 
                 265

 cctcattcac atatggcttt ttttttaacc aataacaatt aggtgtactt ctattttaaa    997

 acatttcaga aaaaaatata tgttatagca atactcttac tcaaaagaag aaatttccta   1057

 actctatcag ataaactcat ctttagtata aataagcatt atttgcaggt tgccacaggt   1117

 gga                                                                 1120




      <210> 26
      <211> 4431
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (25)..(2694)

      <400> 26
 gcgcggcgcc gctcggtgca gacc   atg aat tac gtg ggg cag tta gcc ggc      51
                              Met Asn Tyr Val Gly Gln Leu Ala Gly
                                1               5

 cag gtg ttt gtc acc gtg aag gag ctc tac aag ggg ctg aat ccc gcc       99
 Gln Val Phe Val Thr Val Lys Glu Leu Tyr Lys Gly Leu Asn Pro Ala
  10                  15                  20                  25

 aca ctc tca ggg tgc att gac atc att gtc atc cgc cag ccc aat gga      147
 Thr Leu Ser Gly Cys Ile Asp Ile Ile Val Ile Arg Gln Pro Asn Gly
                  30                  35                  40

 aac ctc caa tgc tcc cct ttc cac gtc cgc ttt ggg aag atg ggg gtc      195
 Asn Leu Gln Cys Ser Pro Phe His Val Arg Phe Gly Lys Met Gly Val
              45                  50                  55

 ctg cgc tcc cga gag aaa gtg gtt gac ata gaa atc aat ggg gaa tct      243
 Leu Arg Ser Arg Glu Lys Val Val Asp Ile Glu Ile Asn Gly Glu Ser
          60                  65                  70

 gtg gat ttg cat atg aaa ttg gga gat aat gga gaa gca ttt ttt gtt      291
 Val Asp Leu His Met Lys Leu Gly Asp Asn Gly Glu Ala Phe Phe Val
      75                  80                  85

 caa gaa aca gat aat gat cag gaa gtt atc cct atg cac ctg gcc acc      339
 Gln Glu Thr Asp Asn Asp Gln Glu Val Ile Pro Met His Leu Ala Thr
  90                  95                 100                 105

 tcc ccc atc ctg tca gaa gga gct tcg aga atg gaa tgc cag ctg aaa      387
 Ser Pro Ile Leu Ser Glu Gly Ala Ser Arg Met Glu Cys Gln Leu Lys
                 110                 115                 120

 agg ggc tct gtg gac agg atg aga ggc ctg gac ccc agc acg cca gcc      435
 Arg Gly Ser Val Asp Arg Met Arg Gly Leu Asp Pro Ser Thr Pro Ala
             125                 130                 135

 caa gtg atc gct ccc agc gag acg ccg tca agc agc tct gta gta aag      483
 Gln Val Ile Ala Pro Ser Glu Thr Pro Ser Ser Ser Ser Val Val Lys
         140                 145                 150

 aag aga aga aaa agg agg aga aag tca cag ctg gac agc ctg aag aga      531
 Lys Arg Arg Lys Arg Arg Arg Lys Ser Gln Leu Asp Ser Leu Lys Arg
     155                 160                 165

 gat gac aac atg aac aca tct gag gat gag gac atg ttc ccc atc gag      579
 Asp Asp Asn Met Asn Thr Ser Glu Asp Glu Asp Met Phe Pro Ile Glu
 170                 175                 180                 185

 atg agc tcg gat gag gcc atg gag ctg ctg gag agc agc aga act ctt      627
 Met Ser Ser Asp Glu Ala Met Glu Leu Leu Glu Ser Ser Arg Thr Leu
                 190                 195                 200

 cct aat gat ata cct cca ttc caa gat gat att cct gag gaa aac ctc      675
 Pro Asn Asp Ile Pro Pro Phe Gln Asp Asp Ile Pro Glu Glu Asn Leu
             205                 210                 215

 tcc ctg gct gtg att tac cct cag tca gcc tca tac cct aat tcg gat      723
 Ser Leu Ala Val Ile Tyr Pro Gln Ser Ala Ser Tyr Pro Asn Ser Asp
         220                 225                 230

 aga gag tgg tca ccc act ccc agt cct tcc ggt tcc cga cct tca aca      771
 Arg Glu Trp Ser Pro Thr Pro Ser Pro Ser Gly Ser Arg Pro Ser Thr
     235                 240                 245

 cct aaa agt gat tca gaa ttg gtc agc aag tcc acg gaa agg aca ggg      819
 Pro Lys Ser Asp Ser Glu Leu Val Ser Lys Ser Thr Glu Arg Thr Gly
 250                 255                 260                 265

 cag aag aac cca gaa atg ctt tgg ctg tgg gga gag ctg ccg cag gct      867
 Gln Lys Asn Pro Glu Met Leu Trp Leu Trp Gly Glu Leu Pro Gln Ala
                 270                 275                 280

 gct aag tct tct tct cca cac aag atg aaa gag tcc agc cca ttg agc      915
 Ala Lys Ser Ser Ser Pro His Lys Met Lys Glu Ser Ser Pro Leu Ser
             285                 290                 295

 agt aga aaa att tgt gat aaa agt cac ttt cag gcc att cac agc gaa      963
 Ser Arg Lys Ile Cys Asp Lys Ser His Phe Gln Ala Ile His Ser Glu
         300                 305                 310

 tct tca gac act ttt agt gac caa tcg cca act ctg gtc ggt ggg gca     1011
 Ser Ser Asp Thr Phe Ser Asp Gln Ser Pro Thr Leu Val Gly Gly Ala
     315                 320                 325

 ctt ttg gac cag aac aag cct cag aca gaa atg cag ttt gtg aat gaa     1059
 Leu Leu Asp Gln Asn Lys Pro Gln Thr Glu Met Gln Phe Val Asn Glu
 330                 335                 340                 345

 gaa gac ctg gag acc tta gga gca gca gcg cca ctc ttg ccc atg atc     1107
 Glu Asp Leu Glu Thr Leu Gly Ala Ala Ala Pro Leu Leu Pro Met Ile
                 350                 355                 360

 gag gag ctc aaa ccc ccc tct gcc agt gta gtc cag aca gca aac aag     1155
 Glu Glu Leu Lys Pro Pro Ser Ala Ser Val Val Gln Thr Ala Asn Lys
             365                 370                 375

 acg gat tct cct tcc agg aaa aga gat aaa cga agc cga cat ctt ggt     1203
 Thr Asp Ser Pro Ser Arg Lys Arg Asp Lys Arg Ser Arg His Leu Gly
         380                 385                 390

 gct gac ggc gtc tac ttg gat gac ctc aca gac atg gat cct gaa gtg     1251
 Ala Asp Gly Val Tyr Leu Asp Asp Leu Thr Asp Met Asp Pro Glu Val
     395                 400                 405

 gcg gcc ctg tat ttt ccc aaa aac gga gat cct tcc gga ctc gca aaa     1299
 Ala Ala Leu Tyr Phe Pro Lys Asn Gly Asp Pro Ser Gly Leu Ala Lys
 410                 415                 420                 425

 cat gca agc gac aac gga gcc cgg tca gcc aac cag tcc ccg cag tcg     1347
 His Ala Ser Asp Asn Gly Ala Arg Ser Ala Asn Gln Ser Pro Gln Ser
                 430                 435                 440

 gtg ggc agc tcg ggc gtg gac agt ggc gtg gag agc acc tcg gac ggg     1395
 Val Gly Ser Ser Gly Val Asp Ser Gly Val Glu Ser Thr Ser Asp Gly
             445                 450                 455

 ctg agg gac ctc cct tcc atc gcc atc tcc ctc tgc ggg ggc ctc agc     1443
 Leu Arg Asp Leu Pro Ser Ile Ala Ile Ser Leu Cys Gly Gly Leu Ser
         460                 465                 470

 gac cac cgg gag atc acg aaa gat gca ttc ctg gag caa gct gtg tca     1491
 Asp His Arg Glu Ile Thr Lys Asp Ala Phe Leu Glu Gln Ala Val Ser
     475                 480                 485

 tat caa cag ttt gtg gac aac ccc gct att atc gat gac ccc aat ctc     1539
 Tyr Gln Gln Phe Val Asp Asn Pro Ala Ile Ile Asp Asp Pro Asn Leu
 490                 495                 500                 505

 gtg gta aag att ggg agt aaa tat tat aac tgg aca aca gca gca ccc     1587
 Val Val Lys Ile Gly Ser Lys Tyr Tyr Asn Trp Thr Thr Ala Ala Pro
                 510                 515                 520

 ctc ctc ctg gca atg cag gcc ttc cag aaa cct ttg cca aag gcc act     1635
 Leu Leu Leu Ala Met Gln Ala Phe Gln Lys Pro Leu Pro Lys Ala Thr
             525                 530                 535

 gtg gaa tct atc atg agg gat aaa atg ccc aaa aag gga gga aga tgg     1683
 Val Glu Ser Ile Met Arg Asp Lys Met Pro Lys Lys Gly Gly Arg Trp
         540                 545                 550

 tgg ttt tca tgg agg gga aga aac acc aca atc aag gag gaa agt aag     1731
 Trp Phe Ser Trp Arg Gly Arg Asn Thr Thr Ile Lys Glu Glu Ser Lys
     555                 560                 565

 cca gag cag tgc ttg gct ggc aag gcc cat agc acc gga gag caa ccg     1779
 Pro Glu Gln Cys Leu Ala Gly Lys Ala His Ser Thr Gly Glu Gln Pro
 570                 575                 580                 585

 ccg cag ctc agc ttg gcc acc agg gta aag cat gaa tca tcc tcc agt     1827
 Pro Gln Leu Ser Leu Ala Thr Arg Val Lys His Glu Ser Ser Ser Ser
                 590                 595                 600

 gat gag gag cgc gca gct gcc aag cca tca aac gca ggc cac ctc cct     1875
 Asp Glu Glu Arg Ala Ala Ala Lys Pro Ser Asn Ala Gly His Leu Pro
             605                 610                 615

 ctt ctg cct aat gtc agc tac aag aag act ctc cgg ctg act tcc gag     1923
 Leu Leu Pro Asn Val Ser Tyr Lys Lys Thr Leu Arg Leu Thr Ser Glu
         620                 625                 630

 cag ctt aaa agc ttg aag ttg aag aat ggc ccc aac gac gtg gtt ttc     1971
 Gln Leu Lys Ser Leu Lys Leu Lys Asn Gly Pro Asn Asp Val Val Phe
     635                 640                 645

 agt gtc acc acg cag tac caa ggc acg tgc cgc tgt gag ggc acc atc     2019
 Ser Val Thr Thr Gln Tyr Gln Gly Thr Cys Arg Cys Glu Gly Thr Ile
 650                 655                 660                 665

 tat ctg tgg aac tgg gat gat aaa gtc atc att tct gat att gat ggg     2067
 Tyr Leu Trp Asn Trp Asp Asp Lys Val Ile Ile Ser Asp Ile Asp Gly
                 670                 675                 680

 aca att acc aga tca gat act ctt ggc cac att ttg ccc acc ctt ggg     2115
 Thr Ile Thr Arg Ser Asp Thr Leu Gly His Ile Leu Pro Thr Leu Gly
             685                 690                 695

 aag gat tgg acc cat cag ggc atc gct aag ctg tac cat aaa gtg agc     2163
 Lys Asp Trp Thr His Gln Gly Ile Ala Lys Leu Tyr His Lys Val Ser
         700                 705                 710

 cag aat gga tat aaa ttt ctc tac tgt tct gcc cgt gcc atc ggg atg     2211
 Gln Asn Gly Tyr Lys Phe Leu Tyr Cys Ser Ala Arg Ala Ile Gly Met
     715                 720                 725

 gcg gac atg acg cgg ggc tac ctg cac tgg gtc aac gag agg ggc acg     2259
 Ala Asp Met Thr Arg Gly Tyr Leu His Trp Val Asn Glu Arg Gly Thr
 730                 735                 740                 745

 gtg ctg ccc cag ggg ccc ctg ctg ctg agt ccc agc agc ctc ttc tct     2307
 Val Leu Pro Gln Gly Pro Leu Leu Leu Ser Pro Ser Ser Leu Phe Ser
                 750                 755                 760

 gcc ctg cac aga gaa gtg att gaa aag aag cca gaa aag ttt aaa gtc     2355
 Ala Leu His Arg Glu Val Ile Glu Lys Lys Pro Glu Lys Phe Lys Val
             765                 770                 775

 cag tgt ttg aca gac atc aaa aac ctg ttt ttc ccc aac aca gaa ccc     2403
 Gln Cys Leu Thr Asp Ile Lys Asn Leu Phe Phe Pro Asn Thr Glu Pro
         780                 785                 790

 ttt tat gct gct ttt gga aac cga cca gct gat gtg tat tca tac aag     2451
 Phe Tyr Ala Ala Phe Gly Asn Arg Pro Ala Asp Val Tyr Ser Tyr Lys
     795                 800                 805

 caa gta gga gtg tct ttg aat aga ata ttt acc gtc aac cct aaa gga     2499
 Gln Val Gly Val Ser Leu Asn Arg Ile Phe Thr Val Asn Pro Lys Gly
 810                 815                 820                 825

 gag ctg gta cag gaa cat gca aag acc aac atc tct tcg tat gtg aga     2547
 Glu Leu Val Gln Glu His Ala Lys Thr Asn Ile Ser Ser Tyr Val Arg
                 830                 835                 840

 ctc tgt gaa gta gtc gac cac gtt ttc ccg ttg ctg aaa aga agc cat     2595
 Leu Cys Glu Val Val Asp His Val Phe Pro Leu Leu Lys Arg Ser His
             845                 850                 855

 tct tca gac ttt ccc tgt tcg gat acc ttc agt aac ttc acc ttt tgg     2643
 Ser Ser Asp Phe Pro Cys Ser Asp Thr Phe Ser Asn Phe Thr Phe Trp
         860                 865                 870

 aga gag cca ctg cca cct ttt gaa aac cag gac att cat tct gcc tca     2691
 Arg Glu Pro Leu Pro Pro Phe Glu Asn Gln Asp Ile His Ser Ala Ser
     875                 880                 885

 gcg taaa atgtcccaag cagcctcttg ccagcagtgc agagcctggt tgtcacccat     2748
 Ala 
 890

 taaaggatag gtctccccgg agtgcacagc tccacctggg agcctggcgc gtcatcattg   2808

 gcctgacagc agagagaatt gagaagcatt tctcccctgc cccaccccgg ggctgacatt   2868

 tctaagcaag ataggaaggg agcactttct aggctaggag ttgggtgcat ttgtaccgtg   2928

 aaaagcattc ctcagttgtg gcttaatgcc agttacgacg ctgcctttcc ggcctgctcc   2988

 agcaagtagc tactggttca cgtgcagttt ggggctgtga aacctaggca gaaggcggct   3048

 gtctgagggc tgtccccgcc taggacaggg tcaatcgagg aatgccagat gtgcacggtt   3108

 tttggcaaag tagggggcac atttccatta tagcaatgtt agtgccacca ccttctgaac   3168

 acagtgggga gggctgtgaa ggctcatgtg acctggatct gaggtctctg atagaaatct   3228

 ggacgccacc gggtccaggc ctggcctcag acttggcctt gtggatgggc cccttacagt   3288

 atttgctgac tagtctcatt tttaggtgat aagtttttct ttaattcctt tggttaaaga   3348

 tagtctattt cattggcata tctcccccca gtttttgtgg ctcaaggctg gaatatttat   3408

 gccttaatat atctatggca gacatttaag aatgcgcttt atctagctca tggtaacttt   3468

 gcaacgcctt agattaaaat gacagtaaat attactaagg cagtattttg aatgagtttg   3528

 acactgccgg cttccttcca tccagcgagg tggtgctgac agtgtggact tgagcacact   3588

 tatgccaaat gataatgata ctgacttctg ttgggagctc tccaaagaaa ctggttggtt   3648

 ttaagaaaat agtttcaaga agttcaacta tattctttta gatattatgt attgttttac   3708

 tctgattagg ttactgtgat aggcatttat tcatattctt tctataccac tgtcattaat   3768

 atattaaaaa gatgtatgtg ttagactatc aaaagggcct tattctctct ttctcataga   3828

 ctgaccttct tttggaattt ctgagtcatt tattttcctt agctttttcc actcaaatta   3888

 agggcaagcg aaaaagtaat aatttggcat tctttaagcc tacagaatgt gattctttca   3948

 cttgtttatt acactggctc gtggacagaa caatttgaaa agtgaaagaa ttattttggt   4008

 aaaagatttt gctttacttt tcgaagcatt atttttttaa agagtgtttt actccaacga   4068

 ttgaaacatt ttcctattta aatttcatcg ttagaatcac aggaggcaaa aaatggaacg   4128

 gttgaatgaa attttactct ttctgtgaaa gaaaatccac agagttgttg cctccgttgt   4188

 agttggtggg ccccgttagc attggatgcc tttgccaaat ggttcatgtg gacacacaaa   4248

 ggcaaacaga tctgccatcg atcgcagatt tctgtagaaa cacggatgtg catgtgcaga   4308

 ttcccttttg caggtattaa aaataattaa aaatagtcct gcctgaggtt gcagtgagcc   4368

 gagcttgcac tactgcactc cagcctgggt gacagagtaa gactccatgt caaaaaaaaa   4428

 aaa                                                                 4431




      <210> 27
      <211> 920
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (280)..(675)

      <400> 27
 caacacaggg gcagtctcca ggacctccac accattaaca agatgagcct tgtgctccct     60

 tgggctctag agaggaagcc cctctgagcc ctcagcccct ctttcctccc tctcctaaag    120

 taatttgatc ctcaggaatt tgttctgccc tcatctggcc ctggccagct ctgcatttga    180

 caaatgccag gaagaggaaa ctgttgagaa aacggaacta ctggggaaag ggagggctca    240

 ctgagaacca tcccggtaac ccgaccgccg ctggtcacc   atg aac cac att gtg     294
                                              Met Asn His Ile Val
                                                1               5

 caa acc ttc tct cct gtc aac agc ggc cag cct ccc aac tac gag atg      342
 Gln Thr Phe Ser Pro Val Asn Ser Gly Gln Pro Pro Asn Tyr Glu Met
                  10                  15                  20

 ctc aag gag gag cag gaa gtg gct atg ctg ggg gcg ccc cac aac cct      390
 Leu Lys Glu Glu Gln Glu Val Ala Met Leu Gly Ala Pro His Asn Pro
              25                  30                  35

 gct ccc ccg acg tcc acc gtg atc cac atc cgc agc gag acc tcc gtg      438
 Ala Pro Pro Thr Ser Thr Val Ile His Ile Arg Ser Glu Thr Ser Val
          40                  45                  50

 cct gac cat gtc gtc tgg tcc ctg ttc aac acc ctc ttc atg aac acc      486
 Pro Asp His Val Val Trp Ser Leu Phe Asn Thr Leu Phe Met Asn Thr
      55                  60                  65

 tgc tgc ctg ggc ttc ata gca ttc gcc tac tcc gtg aag tct agg gac      534
 Cys Cys Leu Gly Phe Ile Ala Phe Ala Tyr Ser Val Lys Ser Arg Asp
  70                  75                  80                  85

 agg aag atg gtt ggc gac gtg acc ggg gcc cag gcc tat gcc tcc acc      582
 Arg Lys Met Val Gly Asp Val Thr Gly Ala Gln Ala Tyr Ala Ser Thr
                  90                  95                 100

 gcc aag tgc ctg aac atc tgg gcc ctg att ttg ggc atc ttc atg acc      630
 Ala Lys Cys Leu Asn Ile Trp Ala Leu Ile Leu Gly Ile Phe Met Thr
             105                 110                 115

 att ctg ctc gtc atc atc cca gtg ttg gtc gtc cag gcc cag cga tag      678
 Ile Leu Leu Val Ile Ile Pro Val Leu Val Val Gln Ala Gln Arg 
         120                 125                 130

 atcaggaggc atcattgagg ccaggagctc tgcccgtgac ctgtatccca cgtactctat    738

 cttccattcc tcgccctgcc cccagaggcc aggagctctg cccttgacct gtattccact    798

 tactccacct tccattcctc gccctgtccc cacagccgag tcctgcatca gccctttatc    858

 ctcacacgct tttctacaat ggcattcaat aaagtgtata tgtttctggt aaaaaaaaaa    918

 aa                                                                   920




      <210> 28
      <211> 760
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (90)..(722)

      <400> 28
 aaggatcctt aattaaatta atcccccccc cccccccgct ttccgctcgg ctgttttcct     60

 gcgcaggagc cgcagggccg taggcagcc  atg gcg ccc agc cgg aat ggc atg     113
                                  Met Ala Pro Ser Arg Asn Gly Met
                                    1               5

 gtc ttg aag ccc cac ttc cac aag gac tgg cag cgg cgc gtg gcc acg      161
 Val Leu Lys Pro His Phe His Lys Asp Trp Gln Arg Arg Val Ala Thr
      10                  15                  20

 tgg ttc aac cag ccg gcc cgt aag atc cgc aga cgt aag gcc cgg caa      209
 Trp Phe Asn Gln Pro Ala Arg Lys Ile Arg Arg Arg Lys Ala Arg Gln
  25                  30                  35                  40

 gcc aag gcg cgc cgc atc gcc ccg cgc ccc gcg tcg ggt ccc atc cgg      257
 Ala Lys Ala Arg Arg Ile Ala Pro Arg Pro Ala Ser Gly Pro Ile Arg
                  45                  50                  55

 ccc atc gtg cgc tgc ccc acg gtt cgg tac cac acg aag gtg cgc gcc      305
 Pro Ile Val Arg Cys Pro Thr Val Arg Tyr His Thr Lys Val Arg Ala
              60                  65                  70

 ggc cgc ggc ttc agc ctg gag gag ctc agg gtg gcc ggc att cac aag      353
 Gly Arg Gly Phe Ser Leu Glu Glu Leu Arg Val Ala Gly Ile His Lys
          75                  80                  85

 aag gtg gcc cgg acc atc ggc att tct gtg gat ccg agg agg cgg aac      401
 Lys Val Ala Arg Thr Ile Gly Ile Ser Val Asp Pro Arg Arg Arg Asn
      90                  95                 100

 aag tcc acg gag tcc ctg cag gcc aac gtg cag cgg ctg aag gag tac      449
 Lys Ser Thr Glu Ser Leu Gln Ala Asn Val Gln Arg Leu Lys Glu Tyr
 105                 110                 115                 120

 cgc tcc aaa ctc atc ctc ttc ccc agg aag ccc tcg gcc ccc aag aag      497
 Arg Ser Lys Leu Ile Leu Phe Pro Arg Lys Pro Ser Ala Pro Lys Lys
                 125                 130                 135

 gga gac agt tct gct gaa gaa ctg aaa ctg gcc acc cag ctg acc gga      545
 Gly Asp Ser Ser Ala Glu Glu Leu Lys Leu Ala Thr Gln Leu Thr Gly
             140                 145                 150

 ccg gtc atg ccc gtc cgg aac gtc tat aag aag gag aaa gct cga gtc      593
 Pro Val Met Pro Val Arg Asn Val Tyr Lys Lys Glu Lys Ala Arg Val
         155                 160                 165

 atc act gag gaa gag aag aat ttc aaa gcc ttc gct agt ctc cgt atg      641
 Ile Thr Glu Glu Glu Lys Asn Phe Lys Ala Phe Ala Ser Leu Arg Met
     170                 175                 180

 gcc cgt gcc aac gcc cgg ctc ttc ggc ata cgg gca aaa aga gcc aag      689
 Ala Arg Ala Asn Ala Arg Leu Phe Gly Ile Arg Ala Lys Arg Ala Lys
 185                 190                 195                 200

 gaa gcc gca gaa cag gat gtt gaa aag aaa aaa taaagccc tcctggggac      740
 Glu Ala Ala Glu Gln Asp Val Glu Lys Lys Lys 
                 205                 210

 ttggaatcaa aaaaaaaaaa                                                760




      <210> 29
      <211> 1486
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (629)..(1399)

      <400> 29
 taagcttgcg gccgcggagc tgggaaggcc gagggcgccg ggcacgtctg tgcagatttc     60

 tttagagtcc aggtctgtcg cccgcgtctt cgtcggtggc agcagggctg actggccacg    120

 gcggccatct gctagagcgc atttcttccc atgaaacgcc acctcctccg aagtgcggag    180

 cgaacgcagc caaatctaca caaagactga caagctggat ccactcgacg gaacccaggg    240

 ccaaaaaacg gcggcgagca gcgcctcggg cccgcgatta ccggttttct gagcaccgga    300

 cagcgtgagc cgtgccagcc ctgtctcgcc atcccagccg aggagggcag cgcgatggct    360

 cttccctgcc ttgaaatcaa ccccattgcc agccgctttc gccggcagag cattttccgt    420

 ggggtccatc cggctccaag gcggcctgcg ctggccacgt ggaaagaaac acgcccactg    480

 cctacaggcc acgcccttcc tcccttcgcg catgcgcccc acccgtcctg aggacctccg    540

 aacctgcagg gggcgatgaa agtaggcttg cgctccgctt gtagctgctt ccgggtcaga    600

 ggtcagacgg tctagcgctg cgtgggcc   atg gtg cag ctc cga ccg cga gcg     652
                                  Met Val Gln Leu Arg Pro Arg Ala
                                    1               5

 tct cgc gcc ccg gcg tcg gcg gag gcg atg gtg gac gag ggc cag ctg      700
 Ser Arg Ala Pro Ala Ser Ala Glu Ala Met Val Asp Glu Gly Gln Leu
      10                  15                  20

 gcc tcg gag gag gag gag gcg gag cac ggg ctg ttg ctc ggg cag ccc      748
 Ala Ser Glu Glu Glu Glu Ala Glu His Gly Leu Leu Leu Gly Gln Pro
  25                  30                  35                  40

 agc agc ggc gcg gcc gca gag ccc ctg gag gaa gac gac gaa ggg gac      796
 Ser Ser Gly Ala Ala Ala Glu Pro Leu Glu Glu Asp Asp Glu Gly Asp
                  45                  50                  55

 gat gag ttt gac gat gag gcc ccg gag gag ctg act ttc gcc agc gcc      844
 Asp Glu Phe Asp Asp Glu Ala Pro Glu Glu Leu Thr Phe Ala Ser Ala
              60                  65                  70

 cag gcg gaa gcg aga gaa gag gag cgg cga gtg cgg gag acc gtg cgc      892
 Gln Ala Glu Ala Arg Glu Glu Glu Arg Arg Val Arg Glu Thr Val Arg
          75                  80                  85

 agg gat aaa acg ctc ctg aag gag aag agg aag cga cgc gag gag ctg      940
 Arg Asp Lys Thr Leu Leu Lys Glu Lys Arg Lys Arg Arg Glu Glu Leu
      90                  95                 100

 ttc atc gaa cag aag aaa aga aaa ctc ctt cca gac act att ttg gag      988
 Phe Ile Glu Gln Lys Lys Arg Lys Leu Leu Pro Asp Thr Ile Leu Glu
 105                 110                 115                 120

 aag tta acc aca gct tca cag act aac atc aag aaa tcg cca gga aag     1036
 Lys Leu Thr Thr Ala Ser Gln Thr Asn Ile Lys Lys Ser Pro Gly Lys
                 125                 130                 135

 gtg aaa gaa gtt aat ttg caa aag aaa aat gaa gac tgt gaa aaa gga     1084
 Val Lys Glu Val Asn Leu Gln Lys Lys Asn Glu Asp Cys Glu Lys Gly
             140                 145                 150

 aat gac tcc aag aaa gtt aaa gta caa aaa gta cag tct gtc agc cag     1132
 Asn Asp Ser Lys Lys Val Lys Val Gln Lys Val Gln Ser Val Ser Gln
         155                 160                 165

 aat aaa agc tac ttg gcc gta agg cta aaa gac caa gat ctg aga gat     1180
 Asn Lys Ser Tyr Leu Ala Val Arg Leu Lys Asp Gln Asp Leu Arg Asp
     170                 175                 180

 tca agg caa caa gca gca caa gcc ttc ata cat aat tca tta tat ggg     1228
 Ser Arg Gln Gln Ala Ala Gln Ala Phe Ile His Asn Ser Leu Tyr Gly
 185                 190                 195                 200

 cca gga acc aac agg act act gta aat aag ttc ctg tct ctt gcc aac     1276
 Pro Gly Thr Asn Arg Thr Thr Val Asn Lys Phe Leu Ser Leu Ala Asn
                 205                 210                 215

 aag agg tta cca gtg aaa aga gct gct gtc cag ttt ttg aat aat gct     1324
 Lys Arg Leu Pro Val Lys Arg Ala Ala Val Gln Phe Leu Asn Asn Ala
             220                 225                 230

 tgg gga atc caa aaa aaa caa aat gcc aag agg ttt aaa aga cgg tgg     1372
 Trp Gly Ile Gln Lys Lys Gln Asn Ala Lys Arg Phe Lys Arg Arg Trp
         235                 240                 245

 atg gtc aga aag atg aaa act aag aag taaat caatgctaaa tgaagaatct     1424
 Met Val Arg Lys Met Lys Thr Lys Lys 
     250                 255

 gtactttgta tgtatagaat ttatctaata aatcattgtt agatcatttt aaaaaaaaaa   1484

 aa                                                                  1486




      <210> 30
      <211> 1448
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (112)..(762)

      <400> 30
 cgcgcgggcc ggcggcggcg cgagtggctc gggagcgcgg ctgaccccca ggctgtggtg     60

 agggtctgag agctggtacc acggagcctg ggcaacctcc tccgcccacc c atg ccc     117
                                                          Met Pro
                                                            1

 acc ccg cat gag gct gag aag cag atc aca ggg cca gag gag gcg gac      165
 Thr Pro His Glu Ala Glu Lys Gln Ile Thr Gly Pro Glu Glu Ala Asp
           5                  10                  15

 cgg ccc cct tca atg tcc agt cat gat aca gcc tct cca gcg gcc ccc      213
 Arg Pro Pro Ser Met Ser Ser His Asp Thr Ala Ser Pro Ala Ala Pro
      20                  25                  30

 agc cgc aac ccc tgc tgc ctg tgc tgg tgc tgc tgc tgt agc tgc tcc      261
 Ser Arg Asn Pro Cys Cys Leu Cys Trp Cys Cys Cys Cys Ser Cys Ser
  35                  40                  45                  50

 tgg aac caa gag cgg cgg cgc gcg tgg cag gcc tcc cgg gag agc aag      309
 Trp Asn Gln Glu Arg Arg Arg Ala Trp Gln Ala Ser Arg Glu Ser Lys
                  55                  60                  65

 ctg cag ccc ctc ccc agc tgt gaa gta tgt gcc acg cca agt cct gag      357
 Leu Gln Pro Leu Pro Ser Cys Glu Val Cys Ala Thr Pro Ser Pro Glu
              70                  75                  80

 gag gtg cag agc tgg gcg cag tct ttt gac aag ctg atg cac agc cca      405
 Glu Val Gln Ser Trp Ala Gln Ser Phe Asp Lys Leu Met His Ser Pro
          85                  90                  95

 gcg gga cgc agc gtg ttc cgg gcg ttc ctg cgg aca gag tac agc gag      453
 Ala Gly Arg Ser Val Phe Arg Ala Phe Leu Arg Thr Glu Tyr Ser Glu
     100                 105                 110

 gag aac atg ctc ttc tgg ttg gcc tgc gag gag ctg aag gcc gag gcc      501
 Glu Asn Met Leu Phe Trp Leu Ala Cys Glu Glu Leu Lys Ala Glu Ala
 115                 120                 125                 130

 aac cag cat gtg gta gac gag aag gcg agg ctc atc tac gag gac tac      549
 Asn Gln His Val Val Asp Glu Lys Ala Arg Leu Ile Tyr Glu Asp Tyr
                 135                 140                 145

 gta tcc atc ctg tcc ccc aag gag gtg agc ctg gac tcc cgt gtg cgg      597
 Val Ser Ile Leu Ser Pro Lys Glu Val Ser Leu Asp Ser Arg Val Arg
             150                 155                 160

 gag ggc atc aac aag aag atg cag gag ccg tcc gca cac acg ttc gac      645
 Glu Gly Ile Asn Lys Lys Met Gln Glu Pro Ser Ala His Thr Phe Asp
         165                 170                 175

 gac gcg cag ctg cag atc tac acg ctc atg cac cgg gac tcc tac ccc      693
 Asp Ala Gln Leu Gln Ile Tyr Thr Leu Met His Arg Asp Ser Tyr Pro
     180                 185                 190

 cgc ttc ctc agc tct ccc acc tac cgt gcc ctg ctg ctg cag ggg cca      741
 Arg Phe Leu Ser Ser Pro Thr Tyr Arg Ala Leu Leu Leu Gln Gly Pro
 195                 200                 205                 210

 tca cag tcc tcc tcc gag gcc ta ggccgccccc cagcagcaca gaccccgccg      794
 Ser Gln Ser Ser Ser Glu Ala 
                 215

 cctcctacgg ccgactctgg gttcccttca gggtgttgtt gtcggcaggg ctgtcagggc    854

 acatgcctgg ccggctgggg tccccacccg cggagacggt cctagaccca gtggggagtg    914

 ctgtgtctcc tgggtctgcc cacccgtggc caagcaggaa ctccaggtgc agggcgggcc    974

 tccaggtgca gggcgggcca gaagccccct catcggcccg cagctggctg gcccagtgct   1034

 cctggctggg ggctcttgcg tggtgagagt aggggtcccc ccaggagcca tgctggaccc   1094

 atgagcctcg ctggggcctc ctccccaggc agccaatggg ccccagacaa gcctttggtg   1154

 gggaacagaa cctccgcatc gtgtagtttt gtgacataag gagacctcct acttgagctg   1214

 tctgtacccc agaatcaaac acagaacctc agaaccagat ttaggacctc agaatcctgc   1274

 actcaaggtg gcaggaccca atttctgttt tatatgttca tgaactttaa acctggaaac   1334

 atgtccttac taggtgtttt atcaaaaaaa agttttcata tttatctcta tccctaaccc   1394

 cccaaaaata ggatgtctta ttattgaaga tatttttaaa gcaaaaaaaa aaaa         1448




      <210> 31
      <211> 3692
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (582)..(3689)

      <400> 31
 agattatgag gaacaggcct cattatttta atacattttt tttctaatta taaaaactgc     60

 catcagagca agaagatcca tgaggacaca tttctcttag tttgtttagc ttacttgatg    120

 tttgctctgc aataacacca gctagcatga ggtaattcac tgtaattaga gctgccagtg    180

 acagttgggc aattcagaga gaggcatttg tcaacaggtt ctactttaga caaggagagg    240

 gagaaaaacg ggcatctcct gcagggatgg cttgcctgct cccaaatgga gtaggcaaag    300

 ttcgtcttca tcctcccatt accacattgg gagctgcttt ccttgccttg gctttagatc    360

 ctttctgcgt tctgcctcct ggttacccca gaatgttcca tgtggcctca tatcttcttc    420

 tacgtttccc agtacaggcc cagactttga gtctctcttt aaatagaagg cagcataggc    480

 ttcttctcta ggccataaat ctacgagtga gatccaaatc tgtctcttct tctgttgttt    540

 ttaacaatca ttttcaagct gtgaaaaagg gctcctatga c    atg gtg tcg act     593
                                                  Met Val Ser Thr
                                                    1

 ctg atc aaa cat aac act agc cta gac cag ccc tgt gtc aag cga tgg      641
 Leu Ile Lys His Asn Thr Ser Leu Asp Gln Pro Cys Val Lys Arg Trp
   5                  10                  15                  20

 tca gca atg cat gaa gca gcc aag caa ggc cga aaa gat atc gta gct      689
 Ser Ala Met His Glu Ala Ala Lys Gln Gly Arg Lys Asp Ile Val Ala
                  25                  30                  35

 ctg ctg ctg aaa cat gga ggc aat gtc cac ctg aga gat gga ttt gga      737
 Leu Leu Leu Lys His Gly Gly Asn Val His Leu Arg Asp Gly Phe Gly
              40                  45                  50

 gtc aca cca cta ggc gtc gct gcc gag tat ggt cac tgt gac gtg tta      785
 Val Thr Pro Leu Gly Val Ala Ala Glu Tyr Gly His Cys Asp Val Leu
          55                  60                  65

 gaa cat cta atc cac aaa ggt ggt gat gtg ctt gct ttg gcg gat gat      833
 Glu His Leu Ile His Lys Gly Gly Asp Val Leu Ala Leu Ala Asp Asp
      70                  75                  80

 ggg gcg tcg gtg ctg ttt gag gca gca gga ggt ggc aat ccc gac tgc      881
 Gly Ala Ser Val Leu Phe Glu Ala Ala Gly Gly Gly Asn Pro Asp Cys
  85                  90                  95                 100

 att tcc ctc ctg ctg gaa tat gga gga agc gga aat gta cct aac cga      929
 Ile Ser Leu Leu Leu Glu Tyr Gly Gly Ser Gly Asn Val Pro Asn Arg
                 105                 110                 115

 gca gga cat ctt cct ata cac cga gct gcc tat gag ggg cat tat ctt      977
 Ala Gly His Leu Pro Ile His Arg Ala Ala Tyr Glu Gly His Tyr Leu
             120                 125                 130

 gca ctg aaa tat ctt atc cca gta aca tct aaa aat gca att cgg aaa     1025
 Ala Leu Lys Tyr Leu Ile Pro Val Thr Ser Lys Asn Ala Ile Arg Lys
         135                 140                 145

 agt ggg cta aca cca att cac tca gca gca gat gga caa aat gca cag     1073
 Ser Gly Leu Thr Pro Ile His Ser Ala Ala Asp Gly Gln Asn Ala Gln
     150                 155                 160

 tgt cta gaa ctg ctc att gaa aat ggt ttt gat gtc aac act cta ctt     1121
 Cys Leu Glu Leu Leu Ile Glu Asn Gly Phe Asp Val Asn Thr Leu Leu
 165                 170                 175                 180

 gct gac cac att tcc cag agc tat gac gat gag agg aag act gcg ctg     1169
 Ala Asp His Ile Ser Gln Ser Tyr Asp Asp Glu Arg Lys Thr Ala Leu
                 185                 190                 195

 tat ttt ggc gtt tct aat aat gac gtt cat tgc aca gaa gtc ctt ctg     1217
 Tyr Phe Gly Val Ser Asn Asn Asp Val His Cys Thr Glu Val Leu Leu
             200                 205                 210

 gct gca ggt gca gac cca aac tta gat ccc ctc aac tgt cta ctt gtt     1265
 Ala Ala Gly Ala Asp Pro Asn Leu Asp Pro Leu Asn Cys Leu Leu Val
         215                 220                 225

 gca gtg agg gcc aat aat tat gaa att gtc agg ctg ctt ctc tcc cat     1313
 Ala Val Arg Ala Asn Asn Tyr Glu Ile Val Arg Leu Leu Leu Ser His
     230                 235                 240

 gga gct aat gtc aat tgt tat ttt atg cat gtg aat gac act cgt ttc     1361
 Gly Ala Asn Val Asn Cys Tyr Phe Met His Val Asn Asp Thr Arg Phe
 245                 250                 255                 260

 ccc agt gtc att caa tat gct cta aac gac gag gta atg ctg agg cta     1409
 Pro Ser Val Ile Gln Tyr Ala Leu Asn Asp Glu Val Met Leu Arg Leu
                 265                 270                 275

 ttg ctg aat aat ggc tat caa gtg gag atg tgc ttt gac tgc atg cat     1457
 Leu Leu Asn Asn Gly Tyr Gln Val Glu Met Cys Phe Asp Cys Met His
             280                 285                 290

 ggt gac atc ttt gga aat tca ttt gtg tgg tca gag ata cag gaa gag     1505
 Gly Asp Ile Phe Gly Asn Ser Phe Val Trp Ser Glu Ile Gln Glu Glu
         295                 300                 305

 gtg ctg cca gga tgg aca tct tgt gta ata aaa gat aac ccg gac ctg     1553
 Val Leu Pro Gly Trp Thr Ser Cys Val Ile Lys Asp Asn Pro Asp Leu
     310                 315                 320

 gag tct tct aaa gtg aca gtt gtc atg acc ctg agg agg gaa cca tac     1601
 Glu Ser Ser Lys Val Thr Val Val Met Thr Leu Arg Arg Glu Pro Tyr
 325                 330                 335                 340

 caa gga gat cgc tgt ctt ggg tgc tca cct tcc aca tca ttc ttc tta     1649
 Gln Gly Asp Arg Cys Leu Gly Cys Ser Pro Ser Thr Ser Phe Phe Leu
                 345                 350                 355

 ata cta cag cga aca act ctg tcc aaa ctt gtc aga cca aca ctc ggg     1697
 Ile Leu Gln Arg Thr Thr Leu Ser Lys Leu Val Arg Pro Thr Leu Gly
             360                 365                 370

 gtt tca gga cag aga aaa ggc ctt tcc agc gaa gac cta ttt gaa aca     1745
 Val Ser Gly Gln Arg Lys Gly Leu Ser Ser Glu Asp Leu Phe Glu Thr
         375                 380                 385

 gct cct tct ggg tct gac aaa gca ggg acc atg tct acc ttt ggc tac     1793
 Ala Pro Ser Gly Ser Asp Lys Ala Gly Thr Met Ser Thr Phe Gly Tyr
     390                 395                 400

 cga aga gga ctc agt aaa tac gaa tcc atc gac gag gat gaa ctc ctc     1841
 Arg Arg Gly Leu Ser Lys Tyr Glu Ser Ile Asp Glu Asp Glu Leu Leu
 405                 410                 415                 420

 gcc tcc ctg tca gcc gag gag ctg aag gag cta gag aga gag ttg gaa     1889
 Ala Ser Leu Ser Ala Glu Glu Leu Lys Glu Leu Glu Arg Glu Leu Glu
                 425                 430                 435

 gac att gaa cct gac cgc aac ctt ccc gtg ggg cta agg caa aag agc     1937
 Asp Ile Glu Pro Asp Arg Asn Leu Pro Val Gly Leu Arg Gln Lys Ser
             440                 445                 450

 ctg aca gag aaa acc ccc aca ggg aca ttc agc aga gag gca ctg atg     1985
 Leu Thr Glu Lys Thr Pro Thr Gly Thr Phe Ser Arg Glu Ala Leu Met
         455                 460                 465

 gcc tat tgg gaa aag gag tcc caa aaa ctc ttg gag aag gag agg ctg     2033
 Ala Tyr Trp Glu Lys Glu Ser Gln Lys Leu Leu Glu Lys Glu Arg Leu
     470                 475                 480

 ggg gaa tgt gga aag ctg tct gta gtt gcc agg cat gat gag cag gaa     2081
 Gly Glu Cys Gly Lys Leu Ser Val Val Ala Arg His Asp Glu Gln Glu
 485                 490                 495                 500

 ctt gct gat gga ggg tgc aaa tcc aat tcc cac aac agg gaa aat ctt     2129
 Leu Ala Asp Gly Gly Cys Lys Ser Asn Ser His Asn Arg Glu Asn Leu
                 505                 510                 515

 cga gca gct gtt ggg tgg ctg ggg gag caa ggt agt tgc gtt gca gaa     2177
 Arg Ala Ala Val Gly Trp Leu Gly Glu Gln Gly Ser Cys Val Ala Glu
             520                 525                 530

 gac aaa gag gaa agt gaa gaa gag ctt atc ttt act gaa agt aac agt     2225
 Asp Lys Glu Glu Ser Glu Glu Glu Leu Ile Phe Thr Glu Ser Asn Ser
         535                 540                 545

 gag gtt tct gag gaa gtg tat aca gag gag gag gag gag gag tcc cag     2273
 Glu Val Ser Glu Glu Val Tyr Thr Glu Glu Glu Glu Glu Glu Ser Gln
     550                 555                 560

 gag gaa gag gag gaa gaa gac agt gac gaa gag gaa aga aca att gaa     2321
 Glu Glu Glu Glu Glu Glu Asp Ser Asp Glu Glu Glu Arg Thr Ile Glu
 565                 570                 575                 580

 act gca aaa ggg att aat gga act gta aat tat gat agt gtc aat tct     2369
 Thr Ala Lys Gly Ile Asn Gly Thr Val Asn Tyr Asp Ser Val Asn Ser
                 585                 590                 595

 gac aac tct aag cca aag ata ttt aaa agt caa ata gag aac ata aat     2417
 Asp Asn Ser Lys Pro Lys Ile Phe Lys Ser Gln Ile Glu Asn Ile Asn
             600                 605                 610

 ttg acc aat ggc agc aat ggg agg aac aca gag tcc cca gct gcc att     2465
 Leu Thr Asn Gly Ser Asn Gly Arg Asn Thr Glu Ser Pro Ala Ala Ile
         615                 620                 625

 cac cct tgt gga aat cct aca gtg att gag gac gct ttg gac aag att     2513
 His Pro Cys Gly Asn Pro Thr Val Ile Glu Asp Ala Leu Asp Lys Ile
     630                 635                 640

 aaa agc aat gac cct gac acc aca gaa gtc aat ttg aac aac att gag     2561
 Lys Ser Asn Asp Pro Asp Thr Thr Glu Val Asn Leu Asn Asn Ile Glu
 645                 650                 655                 660

 aac atc aca aca cag acc ctt acc cgc ttt gct gaa gcc ctc aag gac     2609
 Asn Ile Thr Thr Gln Thr Leu Thr Arg Phe Ala Glu Ala Leu Lys Asp
                 665                 670                 675

 aac act gtg gtg aag acg ttc agt ctg gcc aac acg cat gcc gac gac     2657
 Asn Thr Val Val Lys Thr Phe Ser Leu Ala Asn Thr His Ala Asp Asp
             680                 685                 690

 agt gca gcc atg gcc att gca gag atg ctc aaa gtc aat gag cac atc     2705
 Ser Ala Ala Met Ala Ile Ala Glu Met Leu Lys Val Asn Glu His Ile
         695                 700                 705

 acc aac gta aac gtc gag tcc aac ttc ata acg gga aag ggg atc ctg     2753
 Thr Asn Val Asn Val Glu Ser Asn Phe Ile Thr Gly Lys Gly Ile Leu
     710                 715                 720

 gcc atc atg aga gct ctc cag cac aac acg gtg ctc acg gag ctg cgt     2801
 Ala Ile Met Arg Ala Leu Gln His Asn Thr Val Leu Thr Glu Leu Arg
 725                 730                 735                 740

 ttc cat aac cag agg cac atc atg ggc agc cag gtg gaa atg gag att     2849
 Phe His Asn Gln Arg His Ile Met Gly Ser Gln Val Glu Met Glu Ile
                 745                 750                 755

 gtc aag ctg ctg aag gag aac acg acg ctg ctg agg ctg gga tac cat     2897
 Val Lys Leu Leu Lys Glu Asn Thr Thr Leu Leu Arg Leu Gly Tyr His
             760                 765                 770

 ttt gaa ctc cca gga cca aga atg agc atg acg agc att ttg aca aga     2945
 Phe Glu Leu Pro Gly Pro Arg Met Ser Met Thr Ser Ile Leu Thr Arg
         775                 780                 785

 aat atg gat aaa cag agg caa aaa cgt ttg cag gag caa aaa cag cag     2993
 Asn Met Asp Lys Gln Arg Gln Lys Arg Leu Gln Glu Gln Lys Gln Gln
     790                 795                 800

 gag gga tac gat gga gga ccc aat ctt agg acc aaa gtc tgg caa aga     3041
 Glu Gly Tyr Asp Gly Gly Pro Asn Leu Arg Thr Lys Val Trp Gln Arg
 805                 810                 815                 820

 gga aca cct agc tct tca cct tat gta tct ccc agg cac tca ccc tgg     3089
 Gly Thr Pro Ser Ser Ser Pro Tyr Val Ser Pro Arg His Ser Pro Trp
                 825                 830                 835

 tca tcc cca aaa ctc ccc aaa aaa gtc cag act gtg agg agc cgt cct     3137
 Ser Ser Pro Lys Leu Pro Lys Lys Val Gln Thr Val Arg Ser Arg Pro
             840                 845                 850

 ctg tct cct gtg gcc aca cct cct cct cct ccc cct cct cct cct cct     3185
 Leu Ser Pro Val Ala Thr Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro
         855                 860                 865

 ccc cct cct tct tcc caa agg ctg cca cca cct cct cct cct ccc cct     3233
 Pro Pro Pro Ser Ser Gln Arg Leu Pro Pro Pro Pro Pro Pro Pro Pro
     870                 875                 880

 cct cca ctc cca gag aaa aag ctc att acc aga aac att gca gaa gtc     3281
 Pro Pro Leu Pro Glu Lys Lys Leu Ile Thr Arg Asn Ile Ala Glu Val
 885                 890                 895                 900

 atc aaa caa cag gag agt gcc caa cgg gca tta caa aat gga caa aaa     3329
 Ile Lys Gln Gln Glu Ser Ala Gln Arg Ala Leu Gln Asn Gly Gln Lys
                 905                 910                 915

 aag aaa aaa ggg aaa aag gtc aag aaa cag cca aac agt att cta aag     3377
 Lys Lys Lys Gly Lys Lys Val Lys Lys Gln Pro Asn Ser Ile Leu Lys
             920                 925                 930

 gaa ata aaa aat tct ctg agg tca gtg caa gag aag aaa atg gaa gac     3425
 Glu Ile Lys Asn Ser Leu Arg Ser Val Gln Glu Lys Lys Met Glu Asp
         935                 940                 945

 agt tcc cga cct tct acc cca cag aga tca gct cat gag aat ctc atg     3473
 Ser Ser Arg Pro Ser Thr Pro Gln Arg Ser Ala His Glu Asn Leu Met
     950                 955                 960

 gaa gca att cgg gga agc agc ata aaa cag cta aag cgg atg aca gaa     3521
 Glu Ala Ile Arg Gly Ser Ser Ile Lys Gln Leu Lys Arg Met Thr Glu
 965                 970                 975                 980

 gtg ccc tgt gat gac caa atg ctc ggg caa tgt agg gtg act gcc gcc     3569
 Val Pro Cys Asp Asp Gln Met Leu Gly Gln Cys Arg Val Thr Ala Ala
                 985                 990                 995

 aat gag cca aaa tac aat cac atg cat cag agt cag agg ctg gct cct     3617
 Asn Glu Pro Lys Tyr Asn His Met His Gln Ser Gln Arg Leu Ala Pro
            1000                1005                1010

 caa aac aag cca gct ttt ctg gtt aga gat gga cat agg atg ttg gcg     3665
 Gln Asn Lys Pro Ala Phe Leu Val Arg Asp Gly His Arg Met Leu Ala
        1015                1020                1025

 gca tct atc aac acc cag atg ata tga                                 3692
 Ala Ser Ile Asn Thr Gln Met Ile 
    1030                1035





      <210> 32
      <211> 3572
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (582)..(3569)

      <400> 32
 agattatgag gaacaggcct cattatttta atacattttt tttctaatta taaaaactgc     60

 catcagagca agaagatcca tgaggacaca tttctcttag tttgtttagc ttacttgatg    120

 tttgctctgc aataacacca gctagcatga ggtaattcac tgtaattaga gctgccagtg    180

 acagttgggc aattcagaga gaggcatttg tcaacaggtt ctactttaga caaggagagg    240

 gagaaaaacg ggcatctcct gcagggatgg cttgcctgct cccaaatgga gtaggcaaag    300

 ttcgtcttca tcctcccatt accacattgg gagctgcttt ccttgccttg gctttagatc    360

 ctttctgcgt tctgcctcct ggttacccca gaatgttcca tgtggcctca tatcttcttc    420

 tacgtttccc agtacaggcc cagactttga gtctctcttt aaatagaagg cagcataggc    480

 ttcttctcta ggccataaat ctacgagtga gatccaaatc tgtctcttct tctgttgttt    540

 ttaacaatca ttttcaagct gtgaaaaagg gctcctatga c    atg gtg tcg act     593
                                                  Met Val Ser Thr
                                                    1

 ctg atc aaa cat aac act agc cta gac cag ccc tgt gtc aag cga tgg      641
 Leu Ile Lys His Asn Thr Ser Leu Asp Gln Pro Cys Val Lys Arg Trp
   5                  10                  15                  20

 tca gca atg cat gaa gca gcc aag caa ggc cga aaa gat atc gta gct      689
 Ser Ala Met His Glu Ala Ala Lys Gln Gly Arg Lys Asp Ile Val Ala
                  25                  30                  35

 ctg ctg ctg aaa cat gga ggc aat gtc cac ctg aga gat gga ttt gga      737
 Leu Leu Leu Lys His Gly Gly Asn Val His Leu Arg Asp Gly Phe Gly
              40                  45                  50

 gtc aca cca cta ggc gtc gct gcc gag tat ggt cac tgt gac gtg tta      785
 Val Thr Pro Leu Gly Val Ala Ala Glu Tyr Gly His Cys Asp Val Leu
          55                  60                  65

 gaa cat cta atc cac aaa ggt ggt gat gtg ctt gct ttg gcg gat gat      833
 Glu His Leu Ile His Lys Gly Gly Asp Val Leu Ala Leu Ala Asp Asp
      70                  75                  80

 ggg gcg tcg gtg ctg ttt gag gca gca gga ggt ggc aat ccc gac tgc      881
 Gly Ala Ser Val Leu Phe Glu Ala Ala Gly Gly Gly Asn Pro Asp Cys
  85                  90                  95                 100

 att tcc ctc ctg ctg gaa tat gga gga agc gga aat gta cct aac cga      929
 Ile Ser Leu Leu Leu Glu Tyr Gly Gly Ser Gly Asn Val Pro Asn Arg
                 105                 110                 115

 gca gga cat ctt cct ata cac cga gct gcc tat gag ggg cat tat ctt      977
 Ala Gly His Leu Pro Ile His Arg Ala Ala Tyr Glu Gly His Tyr Leu
             120                 125                 130

 gca ctg aaa tat ctt atc cca gta aca tct aaa aat gca att cgg aaa     1025
 Ala Leu Lys Tyr Leu Ile Pro Val Thr Ser Lys Asn Ala Ile Arg Lys
         135                 140                 145

 agt ggg cta aca cca att cac tca gca gca gat gga caa aat gca cag     1073
 Ser Gly Leu Thr Pro Ile His Ser Ala Ala Asp Gly Gln Asn Ala Gln
     150                 155                 160

 tgt cta gaa ctg ctc att gaa aat ggt ttt gat gtc aac act cta ctt     1121
 Cys Leu Glu Leu Leu Ile Glu Asn Gly Phe Asp Val Asn Thr Leu Leu
 165                 170                 175                 180

 gct gac cac att tcc cag agc tat gac gat gag agg aag act gcg ctg     1169
 Ala Asp His Ile Ser Gln Ser Tyr Asp Asp Glu Arg Lys Thr Ala Leu
                 185                 190                 195

 tat ttt ggc gtt tct aat aat gac gtt cat tgc aca gaa gtc ctt ctg     1217
 Tyr Phe Gly Val Ser Asn Asn Asp Val His Cys Thr Glu Val Leu Leu
             200                 205                 210

 gct gca ggt gca gac cca aac tta gat ccc ctc aac tgt cta ctt gtt     1265
 Ala Ala Gly Ala Asp Pro Asn Leu Asp Pro Leu Asn Cys Leu Leu Val
         215                 220                 225

 gca gtg agg gcc aat aat tat gaa att gtc agg ctg ctt ctc tcc cat     1313
 Ala Val Arg Ala Asn Asn Tyr Glu Ile Val Arg Leu Leu Leu Ser His
     230                 235                 240

 gga gct aat gtc aat tgt tat ttt atg cat gtg aat gac act cgt ttc     1361
 Gly Ala Asn Val Asn Cys Tyr Phe Met His Val Asn Asp Thr Arg Phe
 245                 250                 255                 260

 ccc agt gtc att caa tat gct cta aac gac gag gta atg ctg agg cta     1409
 Pro Ser Val Ile Gln Tyr Ala Leu Asn Asp Glu Val Met Leu Arg Leu
                 265                 270                 275

 ttg ctg aat aat ggc tat caa gtg gag atg tgc ttt gac tgc atg cat     1457
 Leu Leu Asn Asn Gly Tyr Gln Val Glu Met Cys Phe Asp Cys Met His
             280                 285                 290

 ggt gac atc ttt gga aat tca ttt gtg tgg tca gag ata cag gaa gag     1505
 Gly Asp Ile Phe Gly Asn Ser Phe Val Trp Ser Glu Ile Gln Glu Glu
         295                 300                 305

 gtg ctg cca gga tgg aca tct tgt gta ata aaa gat aac ccg gac ctg     1553
 Val Leu Pro Gly Trp Thr Ser Cys Val Ile Lys Asp Asn Pro Asp Leu
     310                 315                 320

 gag tct tct aaa gtg aca gtt gtc atg acc ctg agg agg gaa cca tac     1601
 Glu Ser Ser Lys Val Thr Val Val Met Thr Leu Arg Arg Glu Pro Tyr
 325                 330                 335                 340

 caa gga gat cgc tgt ctt ggg tgc tca cct tcc aca tca ttc ttc tta     1649
 Gln Gly Asp Arg Cys Leu Gly Cys Ser Pro Ser Thr Ser Phe Phe Leu
                 345                 350                 355

 ata cta cag cga aca act ctg tcc aaa ctt gtc aga cca aca ctc ggg     1697
 Ile Leu Gln Arg Thr Thr Leu Ser Lys Leu Val Arg Pro Thr Leu Gly
             360                 365                 370

 gtt tca gga cag aga aaa ggc ctt tcc agc gaa gac cta ttt gaa aca     1745
 Val Ser Gly Gln Arg Lys Gly Leu Ser Ser Glu Asp Leu Phe Glu Thr
         375                 380                 385

 gct cct tct ggg tct gac aaa gca ggg acc atg tct acc ttt ggc tac     1793
 Ala Pro Ser Gly Ser Asp Lys Ala Gly Thr Met Ser Thr Phe Gly Tyr
     390                 395                 400

 cga aga gga ctc agt aaa tac gaa tcc atc gac gag gat gaa ctc ctc     1841
 Arg Arg Gly Leu Ser Lys Tyr Glu Ser Ile Asp Glu Asp Glu Leu Leu
 405                 410                 415                 420

 gcc tcc ctg tca gcc gag gag ctg aag gag cta gag aga gag ttg gaa     1889
 Ala Ser Leu Ser Ala Glu Glu Leu Lys Glu Leu Glu Arg Glu Leu Glu
                 425                 430                 435

 gac att gaa cct gac cgc aac ctt ccc gtg ggg cta agg caa aag agc     1937
 Asp Ile Glu Pro Asp Arg Asn Leu Pro Val Gly Leu Arg Gln Lys Ser
             440                 445                 450

 ctg aca gag aaa acc ccc aca ggg aca ttc agc aga gag gca ctg atg     1985
 Leu Thr Glu Lys Thr Pro Thr Gly Thr Phe Ser Arg Glu Ala Leu Met
         455                 460                 465

 gcc tat tgg gaa aag gag tcc caa aaa ctc ttg gag aag gag agg ctg     2033
 Ala Tyr Trp Glu Lys Glu Ser Gln Lys Leu Leu Glu Lys Glu Arg Leu
     470                 475                 480

 ggg gaa tgt gga aag gtt gca gaa gac aaa gag gaa agt gaa gaa gag     2081
 Gly Glu Cys Gly Lys Val Ala Glu Asp Lys Glu Glu Ser Glu Glu Glu
 485                 490                 495                 500

 ctt atc ttt act gaa agt aac agt gag gtt tct gag gaa gtg tat aca     2129
 Leu Ile Phe Thr Glu Ser Asn Ser Glu Val Ser Glu Glu Val Tyr Thr
                 505                 510                 515

 gag gag gag gag gag gag tcc cag gag gaa gag gag gaa gaa gac agt     2177
 Glu Glu Glu Glu Glu Glu Ser Gln Glu Glu Glu Glu Glu Glu Asp Ser
             520                 525                 530

 gac gaa gag gaa aga aca att gaa act gca aaa ggg att aat gga act     2225
 Asp Glu Glu Glu Arg Thr Ile Glu Thr Ala Lys Gly Ile Asn Gly Thr
         535                 540                 545

 gta aat tat gat agt gtc aat tct gac aac tct aag cca aag ata ttt     2273
 Val Asn Tyr Asp Ser Val Asn Ser Asp Asn Ser Lys Pro Lys Ile Phe
     550                 555                 560

 aaa agt caa ata gag aac ata aat ttg acc aat ggc agc aat ggg agg     2321
 Lys Ser Gln Ile Glu Asn Ile Asn Leu Thr Asn Gly Ser Asn Gly Arg
 565                 570                 575                 580

 aac aca gag tcc cca gct gcc att cac cct tgt gga aat cct aca gtg     2369
 Asn Thr Glu Ser Pro Ala Ala Ile His Pro Cys Gly Asn Pro Thr Val
                 585                 590                 595

 att gag gac gct ttg gac aag att aaa agc aat gac cct gac acc aca     2417
 Ile Glu Asp Ala Leu Asp Lys Ile Lys Ser Asn Asp Pro Asp Thr Thr
             600                 605                 610

 gaa gtc aat ttg aac aac att gag aac atc aca aca cag acc ctt acc     2465
 Glu Val Asn Leu Asn Asn Ile Glu Asn Ile Thr Thr Gln Thr Leu Thr
         615                 620                 625

 cgc ttt gct gaa gcc ctc aag gac aac act gtg gtg aag acg ttc agt     2513
 Arg Phe Ala Glu Ala Leu Lys Asp Asn Thr Val Val Lys Thr Phe Ser
     630                 635                 640

 ctg gcc aac acg cat gcc gac gac agt gca gcc atg gcc att gca gag     2561
 Leu Ala Asn Thr His Ala Asp Asp Ser Ala Ala Met Ala Ile Ala Glu
 645                 650                 655                 660

 atg ctc aaa gtc aat gag cac atc acc aac gta aac gtc gag tcc aac     2609
 Met Leu Lys Val Asn Glu His Ile Thr Asn Val Asn Val Glu Ser Asn
                 665                 670                 675

 ttc ata acg gga aag ggg atc ctg gcc atc atg aga gct ctc cag cac     2657
 Phe Ile Thr Gly Lys Gly Ile Leu Ala Ile Met Arg Ala Leu Gln His
             680                 685                 690

 aac acg gtg ctc acg gag ctg cgt ttc cat aac cag agg cac atc atg     2705
 Asn Thr Val Leu Thr Glu Leu Arg Phe His Asn Gln Arg His Ile Met
         695                 700                 705

 ggc agc cag gtg gaa atg gag att gtc aag ctg ctg aag gag aac acg     2753
 Gly Ser Gln Val Glu Met Glu Ile Val Lys Leu Leu Lys Glu Asn Thr
     710                 715                 720

 acg ctg ctg agg ctg gga tac cat ttt gaa ctc cca gga cca aga atg     2801
 Thr Leu Leu Arg Leu Gly Tyr His Phe Glu Leu Pro Gly Pro Arg Met
 725                 730                 735                 740

 agc atg acg agc att ttg aca aga aat atg gat aaa cag agg caa aaa     2849
 Ser Met Thr Ser Ile Leu Thr Arg Asn Met Asp Lys Gln Arg Gln Lys
                 745                 750                 755

 cgt ttg cag gag caa aaa cag cag gag gga tac gat gga gga ccc aat     2897
 Arg Leu Gln Glu Gln Lys Gln Gln Glu Gly Tyr Asp Gly Gly Pro Asn
             760                 765                 770

 ctt agg acc aaa gtc tgg caa aga gga aca cct agc tct tca cct tat     2945
 Leu Arg Thr Lys Val Trp Gln Arg Gly Thr Pro Ser Ser Ser Pro Tyr
         775                 780                 785

 gta tct ccc agg cac tca ccc tgg tca tcc cca aaa ctc ccc aaa aaa     2993
 Val Ser Pro Arg His Ser Pro Trp Ser Ser Pro Lys Leu Pro Lys Lys
     790                 795                 800

 gtc cag act gtg agg agc cgt cct ctg tct cct gtg gcc aca cct cct     3041
 Val Gln Thr Val Arg Ser Arg Pro Leu Ser Pro Val Ala Thr Pro Pro
 805                 810                 815                 820

 cct cct ccc cct cct cct cct cct ccc cct cct tct tcc caa agg ctg     3089
 Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ser Ser Gln Arg Leu
                 825                 830                 835

 cca cca cct cct cct cct ccc cct cct cca ctc cca gag aaa aag ctc     3137
 Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Glu Lys Lys Leu
             840                 845                 850

 att acc aga aac att gca gaa gtc atc aaa caa cag gag agt gcc caa     3185
 Ile Thr Arg Asn Ile Ala Glu Val Ile Lys Gln Gln Glu Ser Ala Gln
         855                 860                 865

 cgg gca tta caa aat gga caa aaa aag aaa aaa ggg aaa aag gtc aag     3233
 Arg Ala Leu Gln Asn Gly Gln Lys Lys Lys Lys Gly Lys Lys Val Lys
     870                 875                 880

 aaa cag cca aac agt att cta aag gaa ata aaa aat tct ctg agg tca     3281
 Lys Gln Pro Asn Ser Ile Leu Lys Glu Ile Lys Asn Ser Leu Arg Ser
 885                 890                 895                 900

 gtg caa gag aag aaa atg gaa gac agt tcc cga cct tct acc cca cag     3329
 Val Gln Glu Lys Lys Met Glu Asp Ser Ser Arg Pro Ser Thr Pro Gln
                 905                 910                 915

 aga tca gct cat gag aat ctc atg gaa gca att cgg gga agc agc ata     3377
 Arg Ser Ala His Glu Asn Leu Met Glu Ala Ile Arg Gly Ser Ser Ile
             920                 925                 930

 aaa cag cta aag cgg atg aca gaa gtg ccc tgt gat gac caa atg ctc     3425
 Lys Gln Leu Lys Arg Met Thr Glu Val Pro Cys Asp Asp Gln Met Leu
         935                 940                 945

 ggg caa tgt agg gtg act gcc gcc aat gag cca aaa tac aat cac atg     3473
 Gly Gln Cys Arg Val Thr Ala Ala Asn Glu Pro Lys Tyr Asn His Met
     950                 955                 960

 cat cag agt cag agg ctg gct cct caa aac aag cca gct ttt ctg gtt     3521
 His Gln Ser Gln Arg Leu Ala Pro Gln Asn Lys Pro Ala Phe Leu Val
 965                 970                 975                 980

 aga gat gga cat agg atg ttg gcg gca tct atc aac acc cag atg ata     3569
 Arg Asp Gly His Arg Met Leu Ala Ala Ser Ile Asn Thr Gln Met Ile 
                 985                 990                 995

 tga                                                                 3572




      <210> 33
      <211> 2261
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (509)..(1582)

      <400> 33
 attcccgtgt cgacccacgc gtccgcgcgt tcccggcagc tgcgggctcc gaggccagag     60

 agaaaagact gcgaggtggc cgcagctgtg gccggagagg tgggagtcgg agcgaggccc    120

 tctcggggga gcagggtgaa cgccggccac tctaggatcc tcactcgggg agaggaggca    180

 tagctcgcgg tgtcacctcc agccgcaacg tactccgggt cggccttgcg ctcggggcct    240

 gagaggggcg gcggcggggt caggggccgc acaaagaatg aaccagcagt ggaagagaaa    300

 atactgtaag ctggctgact gctggtgaag aaaatgcttt atttttgtgg caggcatctg    360

 tgggatctgt aatagaaatg ggatcttcaa tattcatgtt attttctcct ttggtcttat    420

 atgattgtta cctttatgaa gctttagtga ttacaaagca ctttttttgt ccatttttac    480

 ctgagctttg taaactctga tttgcagg   atg gct ggc tgt ggt gaa att gat     532
                                  Met Ala Gly Cys Gly Glu Ile Asp
                                    1               5

 cat tca ata aac atg ctt cct aca aac agg aaa gcg aac gag tcc tgt      580
 His Ser Ile Asn Met Leu Pro Thr Asn Arg Lys Ala Asn Glu Ser Cys
      10                  15                  20

 tct aat act gca cct tct tta acc gtc cct gaa tgt gcc att tgt ctg      628
 Ser Asn Thr Ala Pro Ser Leu Thr Val Pro Glu Cys Ala Ile Cys Leu
  25                  30                  35                  40

 caa aca tgt gtt cat cca gtc agt ctg ccc tgt aag cac gtt ttc tgc      676
 Gln Thr Cys Val His Pro Val Ser Leu Pro Cys Lys His Val Phe Cys
                  45                  50                  55

 tat cta tgt gta aaa gga gct tca tgg ctt gga aag cgg tgt gct ctt      724
 Tyr Leu Cys Val Lys Gly Ala Ser Trp Leu Gly Lys Arg Cys Ala Leu
              60                  65                  70

 tgt cga caa gaa att ccc gag gat ttc ctt gac aag cca acc ttg ttg      772
 Cys Arg Gln Glu Ile Pro Glu Asp Phe Leu Asp Lys Pro Thr Leu Leu
          75                  80                  85

 tca cca gaa gaa ctc aag gca gca agt aga gga aat ggt gaa tat gca      820
 Ser Pro Glu Glu Leu Lys Ala Ala Ser Arg Gly Asn Gly Glu Tyr Ala
      90                  95                 100

 tgg tat tat gaa gga aga aat ggg tgg tgg cag tac gat gag cgc act      868
 Trp Tyr Tyr Glu Gly Arg Asn Gly Trp Trp Gln Tyr Asp Glu Arg Thr
 105                 110                 115                 120

 agt aga gag ctg gaa gat gct ttt tcc aaa ggt aaa aag aac act gaa      916
 Ser Arg Glu Leu Glu Asp Ala Phe Ser Lys Gly Lys Lys Asn Thr Glu
                 125                 130                 135

 atg tta att gct ggc ttt ctg tat gtc gct gat ctt gaa aac atg gtt      964
 Met Leu Ile Ala Gly Phe Leu Tyr Val Ala Asp Leu Glu Asn Met Val
             140                 145                 150

 caa tat agg aga aat gaa cat gga cgt cgc agg aag att aag cga gat     1012
 Gln Tyr Arg Arg Asn Glu His Gly Arg Arg Arg Lys Ile Lys Arg Asp
         155                 160                 165

 ata ata gat ata cca aag aag gga gta gct gga ctt agg cta gac tgt     1060
 Ile Ile Asp Ile Pro Lys Lys Gly Val Ala Gly Leu Arg Leu Asp Cys
     170                 175                 180

 gat gct aat acc gta aac cta gca aga gag agc tct gct gac gga gcg     1108
 Asp Ala Asn Thr Val Asn Leu Ala Arg Glu Ser Ser Ala Asp Gly Ala
 185                 190                 195                 200

 gac agt gta tca gca cag agt gga gct tct gtt cag ccc cta gtg tct     1156
 Asp Ser Val Ser Ala Gln Ser Gly Ala Ser Val Gln Pro Leu Val Ser
                 205                 210                 215

 tct gta agg ccc cta aca tca gta gat ggt cag tta aca agc cct gca     1204
 Ser Val Arg Pro Leu Thr Ser Val Asp Gly Gln Leu Thr Ser Pro Ala
             220                 225                 230

 aca cca tcc cct gat gca agc act tct ctg gaa gac tct ttt gct cat     1252
 Thr Pro Ser Pro Asp Ala Ser Thr Ser Leu Glu Asp Ser Phe Ala His
         235                 240                 245

 tta caa ctc agt gga gac aac aca gct gaa agg agt cat agg gga gaa     1300
 Leu Gln Leu Ser Gly Asp Asn Thr Ala Glu Arg Ser His Arg Gly Glu
     250                 255                 260

 gga gaa gaa gat cat gaa tca cca tct tca ggc agg gta cca gca cca     1348
 Gly Glu Glu Asp His Glu Ser Pro Ser Ser Gly Arg Val Pro Ala Pro
 265                 270                 275                 280

 gac acc tcc att gaa gaa act gaa tca gat gcc agt agt gat agt gag     1396
 Asp Thr Ser Ile Glu Glu Thr Glu Ser Asp Ala Ser Ser Asp Ser Glu
                 285                 290                 295

 gat gta tct gca gtt gtt gca cag cac tcc ttg acc caa cag aga ctt     1444
 Asp Val Ser Ala Val Val Ala Gln His Ser Leu Thr Gln Gln Arg Leu
             300                 305                 310

 ttg gtt tct aat gca aac cag aca gta ccc gat cga tca gat cga tcg     1492
 Leu Val Ser Asn Ala Asn Gln Thr Val Pro Asp Arg Ser Asp Arg Ser
         315                 320                 325

 gga act gat cga tca gta gca ggg ggt gga aca gtg agt gtc agt gtc     1540
 Gly Thr Asp Arg Ser Val Ala Gly Gly Gly Thr Val Ser Val Ser Val
     330                 335                 340

 aga tct aga agg cct gat gga cag tgc aca gta act gaa gtt taaataa     1589
 Arg Ser Arg Arg Pro Asp Gly Gln Cys Thr Val Thr Glu Val 
 345                 350                 355

 aaatgtcttc agctccatgc tcaaggttga aagggttacc tgtaaatttc tgcccacata   1649

 acattatact catccctagt agtgcatttt gggagttggg gtgggaaggg gtatgggaag   1709

 gatagactca taattaaaat gtctaacatg tctctgttga gaaatttatt taatgtaagg   1769

 aacttgggtg ttaatagttg agagctgttt agtaataacc cagttttctt gaggtctgtt   1829

 tactttatac tttttaaaaa cttctgtagt tcttttggcc agtgtgtttg tattatctgt   1889

 gcattaatgg tcctcatctg actcctgcat tgtgtcttat ttttctgcat ggattggcat   1949

 aagaccatta ctaaaatttg gcacctgtga gatgtttgat attatgaaca ggaaacataa   2009

 tttaatgtat gaatagatgt gaatttggga tttcaaaata gatgaataac aactatttta   2069

 tagtaaagtt attgaaatgg aaatgaaaac agccagtaac ttatgtttca gaatgtttgt   2129

 aacacacttc atggtgttcc cataggcttt gctgtctagt cttatagttt gaggtttttt   2189

 tggtctgcat ttttcttttt gattacaaaa tttataattt aataaatact agagtttatc   2249

 aaaaaaaaaa aa                                                       2261




      <210> 34
      <211> 2356
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (85)..(1551)

      <400> 34
 gcacgaggcg gcgccgaaga ggcgactgag gccggacggg gcggacggcg acgcagcccg     60

 cggcagaagt ttgaaattgg caca   atg gaa gaa gct gga att tgt ggg cta     111
                              Met Glu Glu Ala Gly Ile Cys Gly Leu
                                1               5

 ggg gtg aaa gca gat atg ttg tgt aac tct caa tca aat gat att ctt      159
 Gly Val Lys Ala Asp Met Leu Cys Asn Ser Gln Ser Asn Asp Ile Leu
  10                  15                  20                  25

 caa cat caa ggc tca aat tgt ggt ggc aca agt aac aag cat tca ttg      207
 Gln His Gln Gly Ser Asn Cys Gly Gly Thr Ser Asn Lys His Ser Leu
                  30                  35                  40

 gaa gag gat gaa ggc agt gac ttt ata aca gag aac agg aat ttg gtg      255
 Glu Glu Asp Glu Gly Ser Asp Phe Ile Thr Glu Asn Arg Asn Leu Val
              45                  50                  55

 agc cca gca tac tgc acg caa gaa tca aga gag gaa atc cct ggg gga      303
 Ser Pro Ala Tyr Cys Thr Gln Glu Ser Arg Glu Glu Ile Pro Gly Gly
          60                  65                  70

 gaa gct cga aca gat ccc cct gat ggt cag caa gat tca gag tgc aac      351
 Glu Ala Arg Thr Asp Pro Pro Asp Gly Gln Gln Asp Ser Glu Cys Asn
      75                  80                  85

 agg aac aaa gaa aaa act tta gga aaa gaa gtt tta tta ctg atg caa      399
 Arg Asn Lys Glu Lys Thr Leu Gly Lys Glu Val Leu Leu Leu Met Gln
  90                  95                 100                 105

 gcc cta aac acc ctt tca acc cca gag gag aag ctg gca gct ctc tgt      447
 Ala Leu Asn Thr Leu Ser Thr Pro Glu Glu Lys Leu Ala Ala Leu Cys
                 110                 115                 120

 aag aaa tat gct gat ctt ctg gag gag agc agg agt gtt cag aag caa      495
 Lys Lys Tyr Ala Asp Leu Leu Glu Glu Ser Arg Ser Val Gln Lys Gln
             125                 130                 135

 atg aag atc ctg cag aag aag caa gcc cag att gtg aaa gag aaa gtt      543
 Met Lys Ile Leu Gln Lys Lys Gln Ala Gln Ile Val Lys Glu Lys Val
         140                 145                 150

 cac ttg cag agt gaa cat agc aag gct atc ttg gca aga agc aag cta      591
 His Leu Gln Ser Glu His Ser Lys Ala Ile Leu Ala Arg Ser Lys Leu
     155                 160                 165

 gaa tct ctt tgc aga gaa ctt cag cgt cac aat aag acg tta aag gag      639
 Glu Ser Leu Cys Arg Glu Leu Gln Arg His Asn Lys Thr Leu Lys Glu
 170                 175                 180                 185

 gaa aat atg cag cag gca cga gag gaa gaa gaa cga cgt aaa gaa gca      687
 Glu Asn Met Gln Gln Ala Arg Glu Glu Glu Glu Arg Arg Lys Glu Ala
                 190                 195                 200

 act gca cat ttc cag att acc tta aat gaa att caa gcc cag ctg gag      735
 Thr Ala His Phe Gln Ile Thr Leu Asn Glu Ile Gln Ala Gln Leu Glu
             205                 210                 215

 cag cat gac atc cac aac gcc aaa ctc cga cag gaa aac att gag ctg      783
 Gln His Asp Ile His Asn Ala Lys Leu Arg Gln Glu Asn Ile Glu Leu
         220                 225                 230

 ggg gag aag cta aag aag ctc atc gaa cag tac gca ctg agg gaa gag      831
 Gly Glu Lys Leu Lys Lys Leu Ile Glu Gln Tyr Ala Leu Arg Glu Glu
     235                 240                 245

 cac att gat aag gtg ttc aaa cat aag gaa ctg caa cag cag ctc gtg      879
 His Ile Asp Lys Val Phe Lys His Lys Glu Leu Gln Gln Gln Leu Val
 250                 255                 260                 265

 gat gcc aaa ctg cag caa acg aca caa ctg ata aaa gaa gct gat gaa      927
 Asp Ala Lys Leu Gln Gln Thr Thr Gln Leu Ile Lys Glu Ala Asp Glu
                 270                 275                 280

 aaa cat cag aga gag aga gag ttt tta tta aaa gaa gcg aca gaa tcg      975
 Lys His Gln Arg Glu Arg Glu Phe Leu Leu Lys Glu Ala Thr Glu Ser
             285                 290                 295

 agg cac aaa tac gaa caa atg aaa cag caa gaa gta caa cta aaa cag     1023
 Arg His Lys Tyr Glu Gln Met Lys Gln Gln Glu Val Gln Leu Lys Gln
         300                 305                 310

 cag ctt tct ctt tat atg gat aag ttt gaa gaa ttc cag act acc atg     1071
 Gln Leu Ser Leu Tyr Met Asp Lys Phe Glu Glu Phe Gln Thr Thr Met
     315                 320                 325

 gca aaa agc aat gaa ctg ttt aca acc ttc aga cag gaa atg gaa aag     1119
 Ala Lys Ser Asn Glu Leu Phe Thr Thr Phe Arg Gln Glu Met Glu Lys
 330                 335                 340                 345

 atg aca aag aaa att aaa aaa ctg gaa aaa gaa aca ata att tgg cgt     1167
 Met Thr Lys Lys Ile Lys Lys Leu Glu Lys Glu Thr Ile Ile Trp Arg
                 350                 355                 360

 acc aaa tgg gaa aac aat aat aaa gca ctt ctg caa atg gct gaa gag     1215
 Thr Lys Trp Glu Asn Asn Asn Lys Ala Leu Leu Gln Met Ala Glu Glu
             365                 370                 375

 aaa aca gtc cgt gat aaa gag tac aag gcc ctt caa ata aaa ctg gaa     1263
 Lys Thr Val Arg Asp Lys Glu Tyr Lys Ala Leu Gln Ile Lys Leu Glu
         380                 385                 390

 cgg tta gag aag ctg tgc agg gct ctt caa aca gaa agg aat gag ctc     1311
 Arg Leu Glu Lys Leu Cys Arg Ala Leu Gln Thr Glu Arg Asn Glu Leu
     395                 400                 405

 aat gag aag gtg gaa gtc ctg aaa gag cag gta tcc atc aaa gcg gcc     1359
 Asn Glu Lys Val Glu Val Leu Lys Glu Gln Val Ser Ile Lys Ala Ala
 410                 415                 420                 425

 atc aaa gcg gcg aac agg gat tta gca aca cct gtg atg cag ccc tgt     1407
 Ile Lys Ala Ala Asn Arg Asp Leu Ala Thr Pro Val Met Gln Pro Cys
                 430                 435                 440

 act gcc ctg gat tct cac aag gag ctg aac act tcc tcg aaa aga gcc     1455
 Thr Ala Leu Asp Ser His Lys Glu Leu Asn Thr Ser Ser Lys Arg Ala
             445                 450                 455

 ctg gga gcg cac ctg gag gct gag ccc aag agt cag aga agc gct gtg     1503
 Leu Gly Ala His Leu Glu Ala Glu Pro Lys Ser Gln Arg Ser Ala Val
         460                 465                 470

 caa aag ccc ccg tcc aca ggc tct gct ccg gcc atc gag tcg gtt gac     1551
 Gln Lys Pro Pro Ser Thr Gly Ser Ala Pro Ala Ile Glu Ser Val Asp 
     475                 480                 485

 taagatgagg tgtgatcact gtattgagag atatattttg tgtataactt tctctgttag   1611

 tagttaacta ttggttttgt ggtgaaaatt ttcttacttt ttctaccata tctgtatttt   1671

 cttagaacta ctggacttat gtggtacagg aggctgctta gcagttttga atagtttaat   1731

 ctataaattt tcctcagctg tgttgcacat cagcctcgtt ctccctccac tggaatgcat   1791

 gtgttcattg ccttgtcctt tctctccctg ctccttgcac attatcatcc taatgaaaat   1851

 ttcactgaca gggccgacca ttacaaggga actttgttct gacgatggtt ccttgatgtg   1911

 aaaacaatat taatttaaac gtcttagccc ccccccccat aatattattc agaaaaacaa   1971

 aataccaagg cgattagttt tgtctaataa cccatttaaa tgccaagtaa aaataaaact   2031

 cctagtgttg ggtcagaagc atatttgatt gaaattagct ttttgaaaac atttatatct   2091

 cgggacaaat tgagatggcc acatgcctag aatcctaagt ttcggcagaa tatgtatata   2151

 aagatgtcac ttgtggacaa aatagtacat agaggcaaat cactagacaa ataagcttag   2211

 tgtttacgtg actgaacagt catcctgctt tggtttcagg tgtgggattt ggaccatgag   2271

 gggctcccgt aaaggatggc ggtttgtgtt tgattctgat ttgggatttc agtacatatt   2331

 ctccacttcc catagaaggc cactt                                         2356




      <210> 35
      <211> 2654
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (205)..(2511)

      <400> 35
 atttcgtcgg gaggaatgga aggagaaggc ggaatgtggg agggctcagg gggatgtggg     60

 agggacgaac ggagaagggg gagagagggg ggtccagtct cccctggccg agcatttttt    120

 ttttggaagt cctaggactg atctccagga ccagcactct tctcccagcc cttagggtcc    180

 tgctcggcca aggccttccc tgcc   atg cga cct gtc agt gtc tgg cag tgg     231
                              Met Arg Pro Val Ser Val Trp Gln Trp
                                1               5

 agc ccc tgg ggg ctg ctg ctg tgc ctg ctg tgc agt tcg tgc ttg ggg      279
 Ser Pro Trp Gly Leu Leu Leu Cys Leu Leu Cys Ser Ser Cys Leu Gly
  10                  15                  20                  25

 tct ccg tcc cct tcc acg ggc cct gag aag aag gcc ggg agc cag ggg      327
 Ser Pro Ser Pro Ser Thr Gly Pro Glu Lys Lys Ala Gly Ser Gln Gly
                  30                  35                  40

 ctt cgg ttc cgg ctg gct ggc ttc ccc agg aag ccc tac gag ggc cgc      375
 Leu Arg Phe Arg Leu Ala Gly Phe Pro Arg Lys Pro Tyr Glu Gly Arg
              45                  50                  55

 gtg gag ata cag cga gct ggt gaa tgg ggc acc atc tgc gat gat gac      423
 Val Glu Ile Gln Arg Ala Gly Glu Trp Gly Thr Ile Cys Asp Asp Asp
          60                  65                  70

 ttc acg ctg cag gct gcc cac atc ctc tgc cgg gag ctg ggc ttc aca      471
 Phe Thr Leu Gln Ala Ala His Ile Leu Cys Arg Glu Leu Gly Phe Thr
      75                  80                  85

 gag gcc aca ggc tgg acc cac agt gcc aaa tat ggc cct gga aca ggc      519
 Glu Ala Thr Gly Trp Thr His Ser Ala Lys Tyr Gly Pro Gly Thr Gly
  90                  95                 100                 105

 cgc atc tgg ctg gac aac ttg agc tgc agt ggg acc gag cag agt gtg      567
 Arg Ile Trp Leu Asp Asn Leu Ser Cys Ser Gly Thr Glu Gln Ser Val
                 110                 115                 120

 act gaa tgt gcc tcc cgg ggc tgg ggg aac agt gac tgt acg cac gat      615
 Thr Glu Cys Ala Ser Arg Gly Trp Gly Asn Ser Asp Cys Thr His Asp
             125                 130                 135

 gag gat gct ggg gtc atc tgc aaa gac cag cgc ctc cct ggc ttc tcg      663
 Glu Asp Ala Gly Val Ile Cys Lys Asp Gln Arg Leu Pro Gly Phe Ser
         140                 145                 150

 gac tcc aat gtc att gag gta gag cat cac ctg caa gtg gag gag gtg      711
 Asp Ser Asn Val Ile Glu Val Glu His His Leu Gln Val Glu Glu Val
     155                 160                 165

 cga att cga ccc gcc gtt ggg tgg ggc aga cga ccc ctg ccc gtg acg      759
 Arg Ile Arg Pro Ala Val Gly Trp Gly Arg Arg Pro Leu Pro Val Thr
 170                 175                 180                 185

 gag ggg ctg gtg gaa gtc agg ctt cct gac ggc tgg tcg caa gtg tgc      807
 Glu Gly Leu Val Glu Val Arg Leu Pro Asp Gly Trp Ser Gln Val Cys
                 190                 195                 200

 gac aaa ggc tgg agc gcc cac aac agc cac gtg gtc tgc ggg atg ctg      855
 Asp Lys Gly Trp Ser Ala His Asn Ser His Val Val Cys Gly Met Leu
             205                 210                 215

 ggc ttc ccc agc gaa aag agg gtc aac gcg gcc ttc tac aga aag ttg      903
 Gly Phe Pro Ser Glu Lys Arg Val Asn Ala Ala Phe Tyr Arg Lys Leu
         220                 225                 230

 agg aag cga gcg gcc aag gtc tca gcc cga cac ccc aag ccc ctt gga      951
 Arg Lys Arg Ala Ala Lys Val Ser Ala Arg His Pro Lys Pro Leu Gly
     235                 240                 245

 agg ctg cta gcc caa cgg cag caa cac tcc ttt ggt ctg cat ggg gtg      999
 Arg Leu Leu Ala Gln Arg Gln Gln His Ser Phe Gly Leu His Gly Val
 250                 255                 260                 265

 gcg tgc gtg ggc acg gag gcc cac ctc tcc ctc tgt tcc ctg gag ttc     1047
 Ala Cys Val Gly Thr Glu Ala His Leu Ser Leu Cys Ser Leu Glu Phe
                 270                 275                 280

 tat cgt gcc aat gac acc gcc agg tgc cct ggg ggg ggc cct gca gtg     1095
 Tyr Arg Ala Asn Asp Thr Ala Arg Cys Pro Gly Gly Gly Pro Ala Val
             285                 290                 295

 gtg agc tgt gtg cca ggc cct gtc tac gcg gca tcc agt ggc cag aag     1143
 Val Ser Cys Val Pro Gly Pro Val Tyr Ala Ala Ser Ser Gly Gln Lys
         300                 305                 310

 aag caa caa cag tcg aag cct cag ggg gag gcc cgt gtc cgt cta aag     1191
 Lys Gln Gln Gln Ser Lys Pro Gln Gly Glu Ala Arg Val Arg Leu Lys
     315                 320                 325

 ggc ggc gcc cac cct gga gag ggc cgg gta gaa gtc ctg aag gcc agc     1239
 Gly Gly Ala His Pro Gly Glu Gly Arg Val Glu Val Leu Lys Ala Ser
 330                 335                 340                 345

 aca tgg ggc aca gtc tgt gac cgc aag tgg gac ctg cat gca gcc agc     1287
 Thr Trp Gly Thr Val Cys Asp Arg Lys Trp Asp Leu His Ala Ala Ser
                 350                 355                 360

 gtg gtg tgt cgg gag ctg ggc ttc ggg agt gct cga gaa gct ctg agt     1335
 Val Val Cys Arg Glu Leu Gly Phe Gly Ser Ala Arg Glu Ala Leu Ser
             365                 370                 375

 ggc gct cgc atg ggg cag ggc atg ggt gct atc cac ctg agt gaa gtt     1383
 Gly Ala Arg Met Gly Gln Gly Met Gly Ala Ile His Leu Ser Glu Val
         380                 385                 390

 cgc tgc tct gga cag gag ctc tcc ctc tgg aag tgc ccc cac aag aac     1431
 Arg Cys Ser Gly Gln Glu Leu Ser Leu Trp Lys Cys Pro His Lys Asn
     395                 400                 405

 atc aca gct gag gat tgt tca cat agc cag gat gcc ggg gtc cgg tgc     1479
 Ile Thr Ala Glu Asp Cys Ser His Ser Gln Asp Ala Gly Val Arg Cys
 410                 415                 420                 425

 aac cta cct tac act ggg gca gag acc agg atc cga ctc agt ggg ggc     1527
 Asn Leu Pro Tyr Thr Gly Ala Glu Thr Arg Ile Arg Leu Ser Gly Gly
                 430                 435                 440

 cgc agc caa cat gag ggg cga gtc gag gtg caa ata ggg gga cct ggg     1575
 Arg Ser Gln His Glu Gly Arg Val Glu Val Gln Ile Gly Gly Pro Gly
             445                 450                 455

 ccc ctt cgc tgg ggc ctc atc tgt ggg gat gac tgg ggg acc ctg gag     1623
 Pro Leu Arg Trp Gly Leu Ile Cys Gly Asp Asp Trp Gly Thr Leu Glu
         460                 465                 470

 gcc atg gtg gcc tgt agg caa ctg ggt ctg ggc tac gcc aac cac ggc     1671
 Ala Met Val Ala Cys Arg Gln Leu Gly Leu Gly Tyr Ala Asn His Gly
     475                 480                 485

 ctg cag gag acc tgg tac tgg gac tct ggg aat ata aca gag gtg gtg     1719
 Leu Gln Glu Thr Trp Tyr Trp Asp Ser Gly Asn Ile Thr Glu Val Val
 490                 495                 500                 505

 atg agt gga gtg cgc tgc aca ggg act gag ctg tcc ctg gat cag tgt     1767
 Met Ser Gly Val Arg Cys Thr Gly Thr Glu Leu Ser Leu Asp Gln Cys
                 510                 515                 520

 gcc cat cat ggc acc cac atc acc tgc aag agg aca ggg acc cgc ttc     1815
 Ala His His Gly Thr His Ile Thr Cys Lys Arg Thr Gly Thr Arg Phe
             525                 530                 535

 act gct gga gtc atc tgt tct gag act gca tca gat ctg ttg ctg cac     1863
 Thr Ala Gly Val Ile Cys Ser Glu Thr Ala Ser Asp Leu Leu Leu His
         540                 545                 550

 tca gca ctg gtg cag gag acc gcc tac atc gaa gac cgg ccc ctg cat     1911
 Ser Ala Leu Val Gln Glu Thr Ala Tyr Ile Glu Asp Arg Pro Leu His
     555                 560                 565

 atg ttg tac tgt gct gcg gaa gag aac tgc ctg gcc agc tca gcc cgc     1959
 Met Leu Tyr Cys Ala Ala Glu Glu Asn Cys Leu Ala Ser Ser Ala Arg
 570                 575                 580                 585

 tca gcc aac tgg ccc tat ggt cac cgg cgt ctg ctc cga ttc tcc tcc     2007
 Ser Ala Asn Trp Pro Tyr Gly His Arg Arg Leu Leu Arg Phe Ser Ser
                 590                 595                 600

 cag atc cac aac ctg gga cga gct gac ttc agg ccc aag gct ggg cgc     2055
 Gln Ile His Asn Leu Gly Arg Ala Asp Phe Arg Pro Lys Ala Gly Arg
             605                 610                 615

 cac tcc tgg gtg tgg cac gag tgc cat ggg cat tac cac agc atg gac     2103
 His Ser Trp Val Trp His Glu Cys His Gly His Tyr His Ser Met Asp
         620                 625                 630

 atc ttc act cac tat gat atc ctc acc cca aat ggc acc aag gtg gct     2151
 Ile Phe Thr His Tyr Asp Ile Leu Thr Pro Asn Gly Thr Lys Val Ala
     635                 640                 645

 gag ggc cac aaa gct agt ttc tgt ctc gaa gac act gag tgt cag gag     2199
 Glu Gly His Lys Ala Ser Phe Cys Leu Glu Asp Thr Glu Cys Gln Glu
 650                 655                 660                 665

 gat gtc tcc aag cgg tat gag tgt gcc aac ttt gga gag caa ggc atc     2247
 Asp Val Ser Lys Arg Tyr Glu Cys Ala Asn Phe Gly Glu Gln Gly Ile
                 670                 675                 680

 act gtg ggt tgc tgg gat ctc tac cgg cat gac att gac tgt cag tgg     2295
 Thr Val Gly Cys Trp Asp Leu Tyr Arg His Asp Ile Asp Cys Gln Trp
             685                 690                 695

 att gac atc acg gat gtg aag cca gga aac tac att ctc cag gtt gtc     2343
 Ile Asp Ile Thr Asp Val Lys Pro Gly Asn Tyr Ile Leu Gln Val Val
         700                 705                 710

 atc aac cca aac ttt gaa gta gca gag agt gac ttt acc aac aat gca     2391
 Ile Asn Pro Asn Phe Glu Val Ala Glu Ser Asp Phe Thr Asn Asn Ala
     715                 720                 725

 atg aaa tgt aac tgc aaa tat gat gga cat aga atc tgg gtg cac aac     2439
 Met Lys Cys Asn Cys Lys Tyr Asp Gly His Arg Ile Trp Val His Asn
 730                 735                 740                 745

 tgc cac att ggt gat gcc ttc agt gaa gag gcc cac agg agg ttt gaa     2487
 Cys His Ile Gly Asp Ala Phe Ser Glu Glu Ala His Arg Arg Phe Glu
                 750                 755                 760

 cgc tcc cct ggc cag acc agc acc tagattatgt aagtgccact gccctttgca    2541
 Arg Ser Pro Gly Gln Thr Ser Thr 
             765

 aaccgcccct ggcgcctaat ggcaggggtc tgaggctgcc attacctcag gagcttatca   2601

 agaaacccat gtcagcaacc atgtattgcg gccgctctag aggaatcgcc agc          2654




      <210> 36
      <211> 1452
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (115)..(636)

      <220>
      <221> misc_feature
      <222> (1)...(1452)
      <223> n = a,t,c or g

      <400> 36
 taagcttgcg gccgcgccgg ctccaggaaa tggctactgc tgacaggaag tttggcatcc     60

 acctccccca gcctcctgag tggacagggg ccctgggcac cacttcagag ggcc  atg     117
                                                              Met
                                                                1

 aag ccc cca gga gga gaa tcg agc aat ctt ttt gga agt cca gaa gaa      165
 Lys Pro Pro Gly Gly Glu Ser Ser Asn Leu Phe Gly Ser Pro Glu Glu
               5                  10                  15

 gct act cct tcc agc agg cct aat agg atg gca tct aat att ttt gga      213
 Ala Thr Pro Ser Ser Arg Pro Asn Arg Met Ala Ser Asn Ile Phe Gly
          20                  25                  30

 cca aca gaa gaa cct cag aac ata ccc aag agg aca aat ccc cca ggg      261
 Pro Thr Glu Glu Pro Gln Asn Ile Pro Lys Arg Thr Asn Pro Pro Gly
      35                  40                  45

 ggt aaa gga agt ggt atc ttt gac gaa tca acc ccc gtg cag act cga      309
 Gly Lys Gly Ser Gly Ile Phe Asp Glu Ser Thr Pro Val Gln Thr Arg
  50                  55                  60                  65

 cag cac ctg aac cca cct gga ggg aag acc agc gac att ttt ggg tct      357
 Gln His Leu Asn Pro Pro Gly Gly Lys Thr Ser Asp Ile Phe Gly Ser
                  70                  75                  80

 ccg gtc act gcc act tca cgc ttg gca cac cca aac aaa ccc aag gat      405
 Pro Val Thr Ala Thr Ser Arg Leu Ala His Pro Asn Lys Pro Lys Asp
              85                  90                  95

 cat gtt ttc tta tgt gaa gga gaa gaa cca aaa tcg gat ctt aaa gct      453
 His Val Phe Leu Cys Glu Gly Glu Glu Pro Lys Ser Asp Leu Lys Ala
         100                 105                 110

 gca agg agc atc ccg gct gga gca gag cca ggt gag aaa ggc agc gcc      501
 Ala Arg Ser Ile Pro Ala Gly Ala Glu Pro Gly Glu Lys Gly Ser Ala
     115                 120                 125

 aga aaa gca ggc ccc gcc aag gag cag gag ccc atg ccc aca gtc gac      549
 Arg Lys Ala Gly Pro Ala Lys Glu Gln Glu Pro Met Pro Thr Val Asp
 130                 135                 140                 145

 agc cat gag ccc cgg ctg ggg ccg cgg gct cgc tct cac aac aag gtc      597
 Ser His Glu Pro Arg Leu Gly Pro Arg Ala Arg Ser His Asn Lys Val
                 150                 155                 160

 ctg aac cca ccg gga ggc aaa tcc agc atc tcc ttc tac taagagaagc       646
 Leu Asn Pro Pro Gly Gly Lys Ser Ser Ile Ser Phe Tyr 
             165                 170

 cactgctcca cccggagcca gaccagaaac tcaagagata gggtagccat gttttcattt    706

 ccttttgccc aaatgagcgg ggtgggaaga gggttagtct tatgtgagcc tggctgctca    766

 gcgtctcctg gccgtcatga cagctgcttg gagacccgtg ccttccagat ggctgggaga    826

 tgcctctgtg gggatgaaat ggggcacccc tggccatcac tcatgtgtag tccaggtttg    886

 agaggaactg gaaggggggt gagggtgggg gagtgcncnn nncatnncnc tcctctctcc    946

 ctccttcctt cttttgcttc ccttgtctcg ctttctcttc ccactctcct gttctctgct   1006

 ctgtggatgg gggctgcgtc gctgctcctc cgcgtttaat tgccttttgt tctcctcgtc   1066

 ctttggtgac ccggttgctt ttcgacttcc acttcattaa ctccacctat tgcttgagta   1126

 gtctattata tactgtagtt gtctcggctc tcctacacat atcatatata gcattggcga   1186

 atctggcttc ggtctatcat tctaggtgat acatttctat atctatcctc tcctggtgct   1246

 gaatcgtccg acaccatatc aaattcgaac ttagtaatga tctgcctatg tactcatact   1306

 tactcttcac ctcgccgtct cctcatactt atctcgctct ttatccgatt ctgtcgtgat   1366

 cactatcgca catctcgtta ctgtccatct tatagattac ttcatcctca gactagactt   1426

 attcgtcaat acacaacatc atcact                                        1452




      <210> 37
      <211> 495
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (74)..(466)

      <400> 37
 gaaatcatgc tgtggcacgc ccggaatccg ggtcgacccc gcgtccgggc aacgctgcgg     60

 ccccgcccac gtc   atg gcg ccc gag gag aac gcg ggg acc gaa ctc ttg     109
                  Met Ala Pro Glu Glu Asn Ala Gly Thr Glu Leu Leu
                    1               5                  10

 ctg cag agt ttg gag cgc cgc ttc ctg gcg gcg cgt gca ctg cgc tcc      157
 Leu Gln Ser Leu Glu Arg Arg Phe Leu Ala Ala Arg Ala Leu Arg Ser
          15                  20                  25

 tta ccc tgg cag agc tta gaa gca aag tta aga gac tca tca gat tct      205
 Leu Pro Trp Gln Ser Leu Glu Ala Lys Leu Arg Asp Ser Ser Asp Ser
      30                  35                  40

 gag ctg ctg cgg gat att ttg cag aag acg tgc tgt ata gcc cag aag      253
 Glu Leu Leu Arg Asp Ile Leu Gln Lys Thr Cys Cys Ile Ala Gln Lys
  45                  50                  55                  60

 cca tcg tgt cgc tgg tcg ggg tcc tgc gga ggc tgg ctg cct acc agg      301
 Pro Ser Cys Arg Trp Ser Gly Ser Cys Gly Gly Trp Leu Pro Thr Arg
                  65                  70                  75

 agc acc agc ggg ctc ctc aag tct atg tgg ccc tta ccg tct gca acc      349
 Ser Thr Ser Gly Leu Leu Lys Ser Met Trp Pro Leu Pro Ser Ala Thr
              80                  85                  90

 cag aga cgt gcc agc tgt tca cca ctg agc tat gcc ggg ctg gga tca      397
 Gln Arg Arg Ala Ser Cys Ser Pro Leu Ser Tyr Ala Gly Leu Gly Ser
          95                 100                 105

 gat ggg aag tgg aac ctc gtc atg acc aga aac tgt ttc cct acg aag      445
 Asp Gly Lys Trp Asn Leu Val Met Thr Arg Asn Cys Phe Pro Thr Lys
     110                 115                 120

 agc act tgg aga tgg caa tgc tgaacctcac actgtaggac tcacatacc          495
 Ser Thr Trp Arg Trp Gln Cys 
 125                 130





      <210> 38
      <211> 863
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (455)..(631)

      <400> 38
 atgaacagtg tgtgaatttt gagtgattcg tggctttggt tgtgagattc aattgtctcc     60

 cttcagaata ggaaccaatg ggcagaaaag gaacaatcgt ggtgcatgtg gtatagtggg    120

 gtaagaacag ctctccagct ccctcactta cccatcctgt gttctggggt taattttcat    180

 gagctgcagg ctcatgtgta aaaatcttcc ttcccatggt gtatatgaag tgagttttgt    240

 gtctaaattc ttagtgagtg ctgaataaat atgtattttt tctgtatttt aacagccaag    300

 actatttaag aatagaaagt cctaaatatt aaaattctta actttgagtg cttataacgg    360

 cctttctcca tgttagccta cttaatcctg aatagccttg ttttacaaat gtggaaacca    420

 cactttagag aagcagcatg ctcaaatcac atag    atg gta ggt ggg aag gta     472
                                          Met Val Gly Gly Lys Val
                                            1               5

 ggc ttg ttt ttc aac act gta aga tct tgg gca gcc ata aaa aag aat      520
 Gly Leu Phe Phe Asn Thr Val Arg Ser Trp Ala Ala Ile Lys Lys Asn
              10                  15                  20

 gag ttc atg tcc ttt gca ggg aca tgg ctg aag ctg gaa gct atc att      568
 Glu Phe Met Ser Phe Ala Gly Thr Trp Leu Lys Leu Glu Ala Ile Ile
          25                  30                  35

 cta agc aaa cta ata cag gaa gag aaa acc aaa cac cac atg ttc tca      616
 Leu Ser Lys Leu Ile Gln Glu Glu Lys Thr Lys His His Met Phe Ser
      40                  45                  50

 ctc ata agt ggg agt tgaacaatga gaacacatgg acacacggag gggaaaatca      671
 Leu Ile Ser Gly Ser 
  55

 catactgggg cctctcgatg ggtggaggac aaggggaaga agactattag gacaaatacc    731

 taatgcatgc ggggcttaaa atgtagatga tgggtcaata ggcgcatcaa accaccatga    791

 cacatgtaca cctatataac aaacctgcat gttctgctcg tgtatcccag aagttaaagt    851

 aaaaaaaaaa aa                                                        863




      <210> 39
      <211> 1437
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (140)..(1114)

      <400> 39
 cctcctcctc cttggcatcc gcctcttctt cctcctgcgt cctcccccgc tgcctccgct     60

 gctcccgacg cggagcccgg agcccgcgcc gagcccctgg cctcgcggtg ccatgctgcc    120

 ccggcggcgg cgctgaagg atg gcg acg ccg ctg cct ccg ccc tcc ccg cgg     172
                      Met Ala Thr Pro Leu Pro Pro Pro Ser Pro Arg
                        1               5                  10

 cac ctg cgg ctg ctg cgg ctg ctg ctc tcc ggc ctc gtc ctc ggc gcc      220
 His Leu Arg Leu Leu Arg Leu Leu Leu Ser Gly Leu Val Leu Gly Ala
              15                  20                  25

 gcc ctg cgt gga gcc gcc gcc ggc cac ccg gat gta gcc gcc tgt ccc      268
 Ala Leu Arg Gly Ala Ala Ala Gly His Pro Asp Val Ala Ala Cys Pro
          30                  35                  40

 ggg agc ctg gac tgt gcc ctg aag agg cgg gca agg tgt cct cct ggt      316
 Gly Ser Leu Asp Cys Ala Leu Lys Arg Arg Ala Arg Cys Pro Pro Gly
      45                  50                  55

 gca cat gcc tgt ggg ccc tgc ctt cag ccc ttc cag gag gac cag caa      364
 Ala His Ala Cys Gly Pro Cys Leu Gln Pro Phe Gln Glu Asp Gln Gln
  60                  65                  70                  75

 ggg ctc tgt gtg ccc agg atg cgc cgg cct cca ggc ggg ggc cgg ccc      412
 Gly Leu Cys Val Pro Arg Met Arg Arg Pro Pro Gly Gly Gly Arg Pro
                  80                  85                  90

 cag ccc aga ctg gaa gat gag att gac ttc ctg gcc cag gag ctt gcc      460
 Gln Pro Arg Leu Glu Asp Glu Ile Asp Phe Leu Ala Gln Glu Leu Ala
              95                 100                 105

 cgg aag gag tct gga cac tca act ccg ccc cta ccc aag gac cga cag      508
 Arg Lys Glu Ser Gly His Ser Thr Pro Pro Leu Pro Lys Asp Arg Gln
         110                 115                 120

 cgg ctc ccg gag cct gcc acc ctg ggc ttc tcg gca cgg ggg cag ggg      556
 Arg Leu Pro Glu Pro Ala Thr Leu Gly Phe Ser Ala Arg Gly Gln Gly
     125                 130                 135

 ctg gag ctg ggc ctc ccc tcc act cca gga acc ccc acg ccc acg ccc      604
 Leu Glu Leu Gly Leu Pro Ser Thr Pro Gly Thr Pro Thr Pro Thr Pro
 140                 145                 150                 155

 cac acc tcc ctg ggc tcc cct gtg tca tcc gac ccg gtg cac atg tcg      652
 His Thr Ser Leu Gly Ser Pro Val Ser Ser Asp Pro Val His Met Ser
                 160                 165                 170

 ccc ctg gag ccc cgg gga ggg caa ggc gac ggc ctc gcc ctt gtg ctg      700
 Pro Leu Glu Pro Arg Gly Gly Gln Gly Asp Gly Leu Ala Leu Val Leu
             175                 180                 185

 atc ctg gcg ttc tgt gtg gcc ggt gca gcc gcc ctc tcc gta gcc tcc      748
 Ile Leu Ala Phe Cys Val Ala Gly Ala Ala Ala Leu Ser Val Ala Ser
         190                 195                 200

 ctc tgc tgg tgc agg ctg cag cgt gag atc cgc ctg act cag aag gcc      796
 Leu Cys Trp Cys Arg Leu Gln Arg Glu Ile Arg Leu Thr Gln Lys Ala
     205                 210                 215

 gac tac gcc act gcg aag gcc cct ggc tca cct gca gct ccc cgg atc      844
 Asp Tyr Ala Thr Ala Lys Ala Pro Gly Ser Pro Ala Ala Pro Arg Ile
 220                 225                 230                 235

 tcg cct ggg gac cag cgg ctg gca cag agc gcg gag atg tac cac tac      892
 Ser Pro Gly Asp Gln Arg Leu Ala Gln Ser Ala Glu Met Tyr His Tyr
                 240                 245                 250

 cag cac caa cgg caa cag atg ctg tgc ctg gag cgg cat aaa gag cca      940
 Gln His Gln Arg Gln Gln Met Leu Cys Leu Glu Arg His Lys Glu Pro
             255                 260                 265

 ccc aag gag ctg gac acg gcc tcc tcg gat gag gag aat gag gac gga      988
 Pro Lys Glu Leu Asp Thr Ala Ser Ser Asp Glu Glu Asn Glu Asp Gly
         270                 275                 280

 gac ttc acg gtg tac gag tgc ccg ggc ctg gcc ccg acc ggg gaa atg     1036
 Asp Phe Thr Val Tyr Glu Cys Pro Gly Leu Ala Pro Thr Gly Glu Met
     285                 290                 295

 gag gtg cgc aac cct ctg ttc gac cac gcc gca ctg tcc gcg ccc ctg     1084
 Glu Val Arg Asn Pro Leu Phe Asp His Ala Ala Leu Ser Ala Pro Leu
 300                 305                 310                 315

 ccg gcc ccc agc tca ccg cct gca ctg cca t gacctggagg cagacagacg     1135
 Pro Ala Pro Ser Ser Pro Pro Ala Leu Pro 
                 320                 325

 cccacctgct ccccgacctc gaggcccccg gggaggggca gggcctggag cttcccacta   1195

 aaaacatgtt ttgatgctgt gtgcttttgg ctgggcctcg ggctccaggc cctgggaccc   1255

 cttgccaggg agacccccga acctttgtgc caggacacct cctggtcccc tgcacctctc   1315

 ctgttcggtt tagaccccca aactggaggg ggcatggaga accgtagagc gcaggaacgg   1375

 gtgggtaatt ctagagacaa aagccaatta aagtccattt cagacctgcg gaaaaaaaaa   1435

 aa                                                                  1437




      <210> 40
      <211> 4119
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4116)

      <400> 40
  atg gat gag agt acc ttt gca gga ggc cag gaa tat ggt gga tgg gtc      48
  Met Asp Glu Ser Thr Phe Ala Gly Gly Gln Glu Tyr Gly Gly Trp Val
    1               5                  10                  15

 cca gaa cac cac aaa agt aac gaa ccc aag agt gga cac att gaa aaa       96
 Pro Glu His His Lys Ser Asn Glu Pro Lys Ser Gly His Ile Glu Lys
              20                  25                  30

 ggt aac aca gat cag tgc caa gaa aga acc cct caa ccc atg att tat      144
 Gly Asn Thr Asp Gln Cys Gln Glu Arg Thr Pro Gln Pro Met Ile Tyr
          35                  40                  45

 ccc aca ggg gaa att gag agc aca gtg aat gcc tgg atg ctc agc cat      192
 Pro Thr Gly Glu Ile Glu Ser Thr Val Asn Ala Trp Met Leu Ser His
      50                  55                  60

 gag aaa gaa caa agt caa atc ctt ttg ata tcg aat tgc ctt gac gct      240
 Glu Lys Glu Gln Ser Gln Ile Leu Leu Ile Ser Asn Cys Leu Asp Ala
  65                  70                  75                  80

 tta aag cac cgg agc tgt gat tat ggt ctg aaa ata gct ctt gac ata      288
 Leu Lys His Arg Ser Cys Asp Tyr Gly Leu Lys Ile Ala Leu Asp Ile
                  85                  90                  95

 aaa cac aga tta aag att cag ccc aag ata ttt atc tat aca agg aca      336
 Lys His Arg Leu Lys Ile Gln Pro Lys Ile Phe Ile Tyr Thr Arg Thr
             100                 105                 110

 cat aaa tat gca gtc acc ctc cac atg ctt gct cat acc att acc tca      384
 His Lys Tyr Ala Val Thr Leu His Met Leu Ala His Thr Ile Thr Ser
         115                 120                 125

 gaa aga gat gac ata gag gaa tgg tta aat gca tgg gta gta gac cag      432
 Glu Arg Asp Asp Ile Glu Glu Trp Leu Asn Ala Trp Val Val Asp Gln
     130                 135                 140

 tgc tgt cca cca gaa atg tct gtg atg atg gaa atg ttc tat att tat      480
 Cys Cys Pro Pro Glu Met Ser Val Met Met Glu Met Phe Tyr Ile Tyr
 145                 150                 155                 160

 gct gtc cac tat ggg aga tca ctt ctt tct tgg agt cag gag gag gag      528
 Ala Val His Tyr Gly Arg Ser Leu Leu Ser Trp Ser Gln Glu Glu Glu
                 165                 170                 175

 aag gag aag gga ggc agg gag gag gag gag gag gag gag gag gag gag      576
 Lys Glu Lys Gly Gly Arg Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
             180                 185                 190

 gag gag gag gag gag gag gag gag gag gag gag gag gag gag gag gag      624
 Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
         195                 200                 205

 gag gca gaa gaa gag aaa tta ggg gag gca gct gtc ccg gag ggt gtc      672
 Glu Ala Glu Glu Glu Lys Leu Gly Glu Ala Ala Val Pro Glu Gly Val
     210                 215                 220

 cag ctc gga tgg ctg act gct ctt tca ctt gtc gtt aac ttc cac cca      720
 Gln Leu Gly Trp Leu Thr Ala Leu Ser Leu Val Val Asn Phe His Pro
 225                 230                 235                 240

 gta gtc tta gtc tcc cct tgg aca tgg tac cga ccg tgt gcc att ctt      768
 Val Val Leu Val Ser Pro Trp Thr Trp Tyr Arg Pro Cys Ala Ile Leu
                 245                 250                 255

 att tca ctt gac cga gcc cga gct gca gcc cag ggt gga agc cgc aag      816
 Ile Ser Leu Asp Arg Ala Arg Ala Ala Ala Gln Gly Gly Ser Arg Lys
             260                 265                 270

 ggc tgg gca gag ttc cag gca aga ggg acc gag agg cgt gag cag tgc      864
 Gly Trp Ala Glu Phe Gln Ala Arg Gly Thr Glu Arg Arg Glu Gln Cys
         275                 280                 285

 tcc gca gcg ctt gtc aga gaa atg gag cag cgg ctc ctt tgt ggg ctc      912
 Ser Ala Ala Leu Val Arg Glu Met Glu Gln Arg Leu Leu Cys Gly Leu
     290                 295                 300

 tta cat ccc cgt cct ggg tgc aca gcc cgg ata ttt gat cta agc gtt      960
 Leu His Pro Arg Pro Gly Cys Thr Ala Arg Ile Phe Asp Leu Ser Val
 305                 310                 315                 320

 gcc cgt tgg cta gct gct cgg tgg gga tct gcc tgc cct ggg ggc gcc     1008
 Ala Arg Trp Leu Ala Ala Arg Trp Gly Ser Ala Cys Pro Gly Gly Ala
                 325                 330                 335

 gcc cgc gct ccc cgc ggt gct ctc gct cct ggg ctg cgc cag tcc gag     1056
 Ala Arg Ala Pro Arg Gly Ala Leu Ala Pro Gly Leu Arg Gln Ser Glu
             340                 345                 350

 gcg gtg ccg gct cct ttg cct ccc cga gtc gca gat gct gcg ggc gcc     1104
 Ala Val Pro Ala Pro Leu Pro Pro Arg Val Ala Asp Ala Ala Gly Ala
         355                 360                 365

 tcc ggg aaa aga tct ggg cgg cgc gct cgc tcg tgc cca agt ccc atg     1152
 Ser Gly Lys Arg Ser Gly Arg Arg Ala Arg Ser Cys Pro Ser Pro Met
     370                 375                 380

 gcg agg gca gcc cga gtg gcc gtc gcg gct gta ggt ccg cat gcc ggg     1200
 Ala Arg Ala Ala Arg Val Ala Val Ala Ala Val Gly Pro His Ala Gly
 385                 390                 395                 400

 cac cgc acc agg cgt cta gca ggt agg ggc agg gaa ggt agg gct gcg     1248
 His Arg Thr Arg Arg Leu Ala Gly Arg Gly Arg Glu Gly Arg Ala Ala
                 405                 410                 415

 ctg gcg gcc ggt gcc cag tta ccg gcg atc ggg gac gct cgg aga cac     1296
 Leu Ala Ala Gly Ala Gln Leu Pro Ala Ile Gly Asp Ala Arg Arg His
             420                 425                 430

 ctg gtc tcc cgg aag cgc cct tcg gaa atg gga ttc gac ccg gct tgc     1344
 Leu Val Ser Arg Lys Arg Pro Ser Glu Met Gly Phe Asp Pro Ala Cys
         435                 440                 445

 ggg cgg cgg gtg ttt aga aga aga ggc tgc ggg caa gca gtg ccc cct     1392
 Gly Arg Arg Val Phe Arg Arg Arg Gly Cys Gly Gln Ala Val Pro Pro
     450                 455                 460

 ctc tgg ttc ccc gga ctc ctc tta gcc ccc tcg tgg cct gat ggg cgg     1440
 Leu Trp Phe Pro Gly Leu Leu Leu Ala Pro Ser Trp Pro Asp Gly Arg
 465                 470                 475                 480

 ccg gga cgg aga gct cat ctc aag ttt gcc ctt ctc tat gga gaa gga     1488
 Pro Gly Arg Arg Ala His Leu Lys Phe Ala Leu Leu Tyr Gly Glu Gly
                 485                 490                 495

 aaa ttt gag tct cca gaa gga aag tat ttt gct aaa cgc caa gca aga     1536
 Lys Phe Glu Ser Pro Glu Gly Lys Tyr Phe Ala Lys Arg Gln Ala Arg
             500                 505                 510

 att aga gga tgg aca cag gaa gat cca gaa gct agt ggc aca tct agc     1584
 Ile Arg Gly Trp Thr Gln Glu Asp Pro Glu Ala Ser Gly Thr Ser Ser
         515                 520                 525

 aac aga gcc aga tca gaa ccc agt gtg tta acc gtg gcc ggg atc tta     1632
 Asn Arg Ala Arg Ser Glu Pro Ser Val Leu Thr Val Ala Gly Ile Leu
     530                 535                 540

 cag aca gag agt cgc aaa act gcc aaa gac att tgc aag atc cgc tgt     1680
 Gln Thr Glu Ser Arg Lys Thr Ala Lys Asp Ile Cys Lys Ile Arg Cys
 545                 550                 555                 560

 ctg tgc gaa gaa aag gaa aac gta ctg aat atc aac tgt gag aac aaa     1728
 Leu Cys Glu Glu Lys Glu Asn Val Leu Asn Ile Asn Cys Glu Asn Lys
                 565                 570                 575

 gga ttt aca aca gtt agc ctg ctc cag ccc ccc cag tat cga atc tat     1776
 Gly Phe Thr Thr Val Ser Leu Leu Gln Pro Pro Gln Tyr Arg Ile Tyr
             580                 585                 590

 cag ctt ttt ctc aat gga aac ctc ttg aca aga ctg tat cca aac gaa     1824
 Gln Leu Phe Leu Asn Gly Asn Leu Leu Thr Arg Leu Tyr Pro Asn Glu
         595                 600                 605

 ttt gtc aat tac tcc aac gcg gtg act ctt cac cta ggt aac aac ggg     1872
 Phe Val Asn Tyr Ser Asn Ala Val Thr Leu His Leu Gly Asn Asn Gly
     610                 615                 620

 tta cag gag atc cga acg ggg gca ttc agt ggc ctg aaa act ctc aaa     1920
 Leu Gln Glu Ile Arg Thr Gly Ala Phe Ser Gly Leu Lys Thr Leu Lys
 625                 630                 635                 640

 aga ctg cat ctc aac aac aac aag ctt gag ata ttg agg gag gac acc     1968
 Arg Leu His Leu Asn Asn Asn Lys Leu Glu Ile Leu Arg Glu Asp Thr
                 645                 650                 655

 ttc cta ggc ctg gag agc ctg gag tat ctc cag gcc gac tac aat tac     2016
 Phe Leu Gly Leu Glu Ser Leu Glu Tyr Leu Gln Ala Asp Tyr Asn Tyr
             660                 665                 670

 atc agt gcc atc gag gct ggg gca ttc agc aaa ctt aac aag ctc aaa     2064
 Ile Ser Ala Ile Glu Ala Gly Ala Phe Ser Lys Leu Asn Lys Leu Lys
         675                 680                 685

 gtg ctc atc ctg aat gac aac ctt ctg ctt tca ctg ccc agc aat gtg     2112
 Val Leu Ile Leu Asn Asp Asn Leu Leu Leu Ser Leu Pro Ser Asn Val
     690                 695                 700

 ttc cgc ttt gtc ctg ctg acc cac tta gac ctc agg ggg aat agg cta     2160
 Phe Arg Phe Val Leu Leu Thr His Leu Asp Leu Arg Gly Asn Arg Leu
 705                 710                 715                 720

 aaa gta atg cct ttt gct ggc gtc ctt gaa cat att gga ggg atc atg     2208
 Lys Val Met Pro Phe Ala Gly Val Leu Glu His Ile Gly Gly Ile Met
                 725                 730                 735

 gag att cag ctg gag gaa aat cca tgg aat tgc act tgt gac tta ctt     2256
 Glu Ile Gln Leu Glu Glu Asn Pro Trp Asn Cys Thr Cys Asp Leu Leu
             740                 745                 750

 cct ctc aag gcc tgg cta gac acc ata act gtt ttt gtg gga gag att     2304
 Pro Leu Lys Ala Trp Leu Asp Thr Ile Thr Val Phe Val Gly Glu Ile
         755                 760                 765

 gtc tgt gag act ccc ttt agg ttg cat ggg aaa gac gtg acc cag ctg     2352
 Val Cys Glu Thr Pro Phe Arg Leu His Gly Lys Asp Val Thr Gln Leu
     770                 775                 780

 acc agg caa gac ctc tgt ccc aga aaa agt gcc agt gat tcc agt cag     2400
 Thr Arg Gln Asp Leu Cys Pro Arg Lys Ser Ala Ser Asp Ser Ser Gln
 785                 790                 795                 800

 agg ggc agc cat gct gac acc cac gtc caa agg ctg tca cct aca atg     2448
 Arg Gly Ser His Ala Asp Thr His Val Gln Arg Leu Ser Pro Thr Met
                 805                 810                 815

 aat cct gct ctc aac cca acc agg gct ccg aaa gcc agc cgg ccg ccc     2496
 Asn Pro Ala Leu Asn Pro Thr Arg Ala Pro Lys Ala Ser Arg Pro Pro
             820                 825                 830

 aaa atg aga aat cgt cca act cct cga gtg act gtg tca aag gac agg     2544
 Lys Met Arg Asn Arg Pro Thr Pro Arg Val Thr Val Ser Lys Asp Arg
         835                 840                 845

 caa agt ttt gga ccc atc atg gtg tac cag acc aag tct cct gtg cct     2592
 Gln Ser Phe Gly Pro Ile Met Val Tyr Gln Thr Lys Ser Pro Val Pro
     850                 855                 860

 ctc acc tgt ccc agc agc tgt gtc tgc acc tct cag agc tca gac aat     2640
 Leu Thr Cys Pro Ser Ser Cys Val Cys Thr Ser Gln Ser Ser Asp Asn
 865                 870                 875                 880

 ggt ctg aat gta aac tgc caa gaa agg aag ttc act aat atc tct gac     2688
 Gly Leu Asn Val Asn Cys Gln Glu Arg Lys Phe Thr Asn Ile Ser Asp
                 885                 890                 895

 ctg cag ccc aaa ccg acc agt cca aag aaa ctc tac cta aca ggg aac     2736
 Leu Gln Pro Lys Pro Thr Ser Pro Lys Lys Leu Tyr Leu Thr Gly Asn
             900                 905                 910

 tat ctt caa act gtc tat aag aat gac ctc tta gaa tac agt tct ttg     2784
 Tyr Leu Gln Thr Val Tyr Lys Asn Asp Leu Leu Glu Tyr Ser Ser Leu
         915                 920                 925

 gac tta ctg cac tta gga aac aac agg att gca gtc att cag gaa ggt     2832
 Asp Leu Leu His Leu Gly Asn Asn Arg Ile Ala Val Ile Gln Glu Gly
     930                 935                 940

 gcc ttt aca aac ctg acc agt tta cgc aga ctt tat ctg aat ggc aat     2880
 Ala Phe Thr Asn Leu Thr Ser Leu Arg Arg Leu Tyr Leu Asn Gly Asn
 945                 950                 955                 960

 tac ctt gaa gtg ctg tac cct tct atg ttt gat gga ctg cag agc ttg     2928
 Tyr Leu Glu Val Leu Tyr Pro Ser Met Phe Asp Gly Leu Gln Ser Leu
                 965                 970                 975

 caa tat ctc tat tta gag tat aat gtc att aag gaa att aag cct ctg     2976
 Gln Tyr Leu Tyr Leu Glu Tyr Asn Val Ile Lys Glu Ile Lys Pro Leu
             980                 985                 990

 acc ttt gat gct ttg att aac cta cag cta ctg ttt ctg aac aac aac     3024
 Thr Phe Asp Ala Leu Ile Asn Leu Gln Leu Leu Phe Leu Asn Asn Asn
         995                1000                1005

 ctt ctt cgg tcc tta cct gat aat ata ttt ggg ggg acg gcc cta acc     3072
 Leu Leu Arg Ser Leu Pro Asp Asn Ile Phe Gly Gly Thr Ala Leu Thr
    1010                1015                1020

 agg ctg aat ctg aga aac aac cat ttt tct cac ctg ccc gtg aaa ggg     3120
 Arg Leu Asn Leu Arg Asn Asn His Phe Ser His Leu Pro Val Lys Gly
1025                1030                1035                1040

 gtt ctg gat cag ctc ccg gct ttc atc cag ata gat ctg cag gag aac     3168
 Val Leu Asp Gln Leu Pro Ala Phe Ile Gln Ile Asp Leu Gln Glu Asn
                1045                1050                1055

 ccc tgg gac tgt acc tgt gac atc atg ggg ctg aaa gac tgg aca gaa     3216
 Pro Trp Asp Cys Thr Cys Asp Ile Met Gly Leu Lys Asp Trp Thr Glu
            1060                1065                1070

 cat gcc aat tcc cct gtc atc att aat gag gtg act tgc gaa tct cct     3264
 His Ala Asn Ser Pro Val Ile Ile Asn Glu Val Thr Cys Glu Ser Pro
        1075                1080                1085

 gct aag cat gca ggg gag ata cta aaa ttt ctg ggg agg gag gct atc     3312
 Ala Lys His Ala Gly Glu Ile Leu Lys Phe Leu Gly Arg Glu Ala Ile
    1090                1095                1100

 tgt cca gac agc cca aac ttg tca gat gga acc gtc ttg tca atg aat     3360
 Cys Pro Asp Ser Pro Asn Leu Ser Asp Gly Thr Val Leu Ser Met Asn
1105                1110                1115                1120

 cac aat aca gac aca cct cgg tcg ctt agt gtg tct cct agt tcc tat     3408
 His Asn Thr Asp Thr Pro Arg Ser Leu Ser Val Ser Pro Ser Ser Tyr
                1125                1130                1135

 cct gaa cta cac act gaa gtt cca ctg tct gtc tta att ctg gga ttg     3456
 Pro Glu Leu His Thr Glu Val Pro Leu Ser Val Leu Ile Leu Gly Leu
            1140                1145                1150

 ctt gtt gtt ttc atc tta tct gtc tgt ttt ggg gct ggt tta ttc gtc     3504
 Leu Val Val Phe Ile Leu Ser Val Cys Phe Gly Ala Gly Leu Phe Val
        1155                1160                1165

 ttt gtc ttg aaa cgc cga aag gga gtg ccg agc gtt ccc agg aat acc     3552
 Phe Val Leu Lys Arg Arg Lys Gly Val Pro Ser Val Pro Arg Asn Thr
    1170                1175                1180

 aac aac tta gac gta agc tcc ttt caa tta cag tat ggg tct tac aac     3600
 Asn Asn Leu Asp Val Ser Ser Phe Gln Leu Gln Tyr Gly Ser Tyr Asn
1185                1190                1195                1200

 act gag act cac gat aaa aca gac ggc cat gtc tac aac tat atc ccc     3648
 Thr Glu Thr His Asp Lys Thr Asp Gly His Val Tyr Asn Tyr Ile Pro
                1205                1210                1215

 cca cct gtg ggt cag atg tgc caa aac ccc atc tac atg cag aag gaa     3696
 Pro Pro Val Gly Gln Met Cys Gln Asn Pro Ile Tyr Met Gln Lys Glu
            1220                1225                1230

 gga gac cca gta gcc tat tac cga aac ctg caa gag ttc agc tat agc     3744
 Gly Asp Pro Val Ala Tyr Tyr Arg Asn Leu Gln Glu Phe Ser Tyr Ser
        1235                1240                1245

 aac ctg gag gag aaa aaa gaa gag cca gcc aca cct gct tac aca ata     3792
 Asn Leu Glu Glu Lys Lys Glu Glu Pro Ala Thr Pro Ala Tyr Thr Ile
    1250                1255                1260

 agt gcc act gag ctg cta gaa aag cag gcc aca cca aga gag cct gag     3840
 Ser Ala Thr Glu Leu Leu Glu Lys Gln Ala Thr Pro Arg Glu Pro Glu
1265                1270                1275                1280

 ctg ctg tat caa aat att gct gag cga gtc aag gaa ctt ccc agc gca     3888
 Leu Leu Tyr Gln Asn Ile Ala Glu Arg Val Lys Glu Leu Pro Ser Ala
                1285                1290                1295

 ggc cta gtc cac tat aac ttt tgt acc tta cct aaa agg cag ttt gcc     3936
 Gly Leu Val His Tyr Asn Phe Cys Thr Leu Pro Lys Arg Gln Phe Ala
            1300                1305                1310

 cct tcc tat gaa tct cga cgc caa aac caa gac aga atc aat aaa acc     3984
 Pro Ser Tyr Glu Ser Arg Arg Gln Asn Gln Asp Arg Ile Asn Lys Thr
        1315                1320                1325

 gtt tta tat gga act ccc agg aaa tgc ttt gtg ggg cag tca aaa ccc     4032
 Val Leu Tyr Gly Thr Pro Arg Lys Cys Phe Val Gly Gln Ser Lys Pro
    1330                1335                1340

 aac cac cct tta ctg caa gct aag ccg caa tca gaa ccg gac tac ctc     4080
 Asn His Pro Leu Leu Gln Ala Lys Pro Gln Ser Glu Pro Asp Tyr Leu
1345                1350                1355                1360

 gaa gtt ctg gaa aaa caa act gca atc agt cag ctg tga                 4119
 Glu Val Leu Glu Lys Gln Thr Ala Ile Ser Gln Leu 
                1365                1370





      <210> 41
      <211> 465
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (16)..(408)

      <400> 41
 cagagagaac ccacc atg gtg ctg tct cct gcc gac aag acc aac gtc aag      51
                  Met Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys
                    1               5                  10

 gcc gcc tgg ggt aag gtc ggc gcg cac gct ggc gag tat ggt gcg gag       99
 Ala Ala Trp Gly Lys Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu
          15                  20                  25

 gcc ctg gag agg atg ttc ctg tcc ttc ccc acc acc aag acc tac ttc      147
 Ala Leu Glu Arg Met Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe
      30                  35                  40

 ccg cac ttc gac ctg agc cac ggc tct gcc cag gtt aag ggc cac ggc      195
 Pro His Phe Asp Leu Ser His Gly Ser Ala Gln Val Lys Gly His Gly
  45                  50                  55                  60

 aag aag gtg gcc gac atg ccc aac gcg ctg tcc gcc ctg agc gac ctg      243
 Lys Lys Val Ala Asp Met Pro Asn Ala Leu Ser Ala Leu Ser Asp Leu
                  65                  70                  75

 cac gcg cac aag ctt cgg gtg gac ccg gtc aac ttc aag ctc cta agc      291
 His Ala His Lys Leu Arg Val Asp Pro Val Asn Phe Lys Leu Leu Ser
              80                  85                  90

 cac tgc ctg ctg gtg acc ctg gcc gcc cac ctc ccc gcc gag ttc acc      339
 His Cys Leu Leu Val Thr Leu Ala Ala His Leu Pro Ala Glu Phe Thr
          95                 100                 105

 cct gcg gtg cac gcc tcc ctg gac aag ttc ctg gct tct gtg agc acc      387
 Pro Ala Val His Ala Ser Leu Asp Lys Phe Leu Ala Ser Val Ser Thr
     110                 115                 120

 gtg ctg acc tcc aaa tac cgt ta agctggagcc tcggtggcca tgcttcttgc      440
 Val Leu Thr Ser Lys Tyr Arg 
 125                 130

 cccttgggcc tccccccagc ccctc                                          465




      <210> 42
      <211> 1484
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (143)..(1360)

      <400> 42
 cgggtcgaga ggacgaggtg ccgctgcctg gagaatcctc cgctgccgtc ggctcccgga     60

 gcccagccct ttcctaaccc aacccaacct agcccagtcc cagccgccag cgcctgtccc    120

 tgtcacggac cccagcgtta cc atg cat cct gcc gtc ttc cta tcc tta ccc     172
                          Met His Pro Ala Val Phe Leu Ser Leu Pro
                            1               5                  10

 gac ctc aga tgc tcc ctt ctg ctc ctg gta act tgg gtt ttt act cct      220
 Asp Leu Arg Cys Ser Leu Leu Leu Leu Val Thr Trp Val Phe Thr Pro
                  15                  20                  25

 gta aca act gaa ata aca agt ctt gat aca gag aat ata gat gaa att      268
 Val Thr Thr Glu Ile Thr Ser Leu Asp Thr Glu Asn Ile Asp Glu Ile
              30                  35                  40

 tta aac aat gct gat gtt gct tta gta aat ttt tat gct gac tgg tgt      316
 Leu Asn Asn Ala Asp Val Ala Leu Val Asn Phe Tyr Ala Asp Trp Cys
          45                  50                  55

 cgt ttc agt cag atg ttg cat cca att ttt gag gaa gct tcc gat gtc      364
 Arg Phe Ser Gln Met Leu His Pro Ile Phe Glu Glu Ala Ser Asp Val
      60                  65                  70

 att aag gaa gaa ttt cca aat gaa aat caa gta gtg ttt gcc aga gtt      412
 Ile Lys Glu Glu Phe Pro Asn Glu Asn Gln Val Val Phe Ala Arg Val
  75                  80                  85                  90

 gat tgt gat cag cac tct gac ata gcc cag aga tac agg ata agc aaa      460
 Asp Cys Asp Gln His Ser Asp Ile Ala Gln Arg Tyr Arg Ile Ser Lys
                  95                 100                 105

 tac cca acc ctc aaa ttg ttt cgt aat ggg atg atg atg aag aga gaa      508
 Tyr Pro Thr Leu Lys Leu Phe Arg Asn Gly Met Met Met Lys Arg Glu
             110                 115                 120

 tac agg ggt cag cga tca gtg aaa gca ttg gca gat tac atc agg caa      556
 Tyr Arg Gly Gln Arg Ser Val Lys Ala Leu Ala Asp Tyr Ile Arg Gln
         125                 130                 135

 caa aaa agt gac ccc att caa gaa att cgg gac tta gca gaa atc acc      604
 Gln Lys Ser Asp Pro Ile Gln Glu Ile Arg Asp Leu Ala Glu Ile Thr
     140                 145                 150

 act ctt gat cgc agc aaa aga aat atc att gga tat ttt gag caa aag      652
 Thr Leu Asp Arg Ser Lys Arg Asn Ile Ile Gly Tyr Phe Glu Gln Lys
 155                 160                 165                 170

 gac tcg gac aac tat aga gtt ttt gaa cga gta gcg aat att ttg cat      700
 Asp Ser Asp Asn Tyr Arg Val Phe Glu Arg Val Ala Asn Ile Leu His
                 175                 180                 185

 gat gac tgt gcc ttt ctt tct gca ttt ggg gat gtt tca aaa ccg gaa      748
 Asp Asp Cys Ala Phe Leu Ser Ala Phe Gly Asp Val Ser Lys Pro Glu
             190                 195                 200

 aga tat agt ggc gac aac ata atc tac aaa cca cca ggg cat tct gct      796
 Arg Tyr Ser Gly Asp Asn Ile Ile Tyr Lys Pro Pro Gly His Ser Ala
         205                 210                 215

 ccg gat atg gtg tac ttg gga gct atg aca aat ttt gat gtg act tac      844
 Pro Asp Met Val Tyr Leu Gly Ala Met Thr Asn Phe Asp Val Thr Tyr
     220                 225                 230

 aat tgg att caa gat aaa tgt gtt cct ctt gtc cga gaa ata aca ttt      892
 Asn Trp Ile Gln Asp Lys Cys Val Pro Leu Val Arg Glu Ile Thr Phe
 235                 240                 245                 250

 gaa aat gga gag gaa ttg aca gaa gaa gga ctg cct ttt ctc ata ctc      940
 Glu Asn Gly Glu Glu Leu Thr Glu Glu Gly Leu Pro Phe Leu Ile Leu
                 255                 260                 265

 ttt cac atg aaa gaa gat aca gaa agt tta gaa ata ttc cag aat gaa      988
 Phe His Met Lys Glu Asp Thr Glu Ser Leu Glu Ile Phe Gln Asn Glu
             270                 275                 280

 gta gct cgg caa tta ata agt gaa aaa ggt aca ata aac ttt tta cat     1036
 Val Ala Arg Gln Leu Ile Ser Glu Lys Gly Thr Ile Asn Phe Leu His
         285                 290                 295

 gcc gat tgt gac aaa ttt aga cat cct ctt ctg cac ata cag aaa act     1084
 Ala Asp Cys Asp Lys Phe Arg His Pro Leu Leu His Ile Gln Lys Thr
     300                 305                 310

 cca gca gat tgt cct gta atc gct att gac agc ttt agg cat atg tat     1132
 Pro Ala Asp Cys Pro Val Ile Ala Ile Asp Ser Phe Arg His Met Tyr
 315                 320                 325                 330

 gtg ttt gga gac ttc aaa gat gta tta att cct gga aaa ctc aag caa     1180
 Val Phe Gly Asp Phe Lys Asp Val Leu Ile Pro Gly Lys Leu Lys Gln
                 335                 340                 345

 ttc gta ttt gac tta cat tct gga aaa ctg cac aga gaa ttc cat cat     1228
 Phe Val Phe Asp Leu His Ser Gly Lys Leu His Arg Glu Phe His His
             350                 355                 360

 gga cct gac cca act gat aca gcc cca gga gag caa gcc caa gat gta     1276
 Gly Pro Asp Pro Thr Asp Thr Ala Pro Gly Glu Gln Ala Gln Asp Val
         365                 370                 375

 gca agc agt cca cct gag agc tcc ttc cag aaa cta gca ccc agt gaa     1324
 Ala Ser Ser Pro Pro Glu Ser Ser Phe Gln Lys Leu Ala Pro Ser Glu
     380                 385                 390

 tat agg tat act cta ttg agg gat cga gat gag ctt taaa aacttgaaaa     1374
 Tyr Arg Tyr Thr Leu Leu Arg Asp Arg Asp Glu Leu 
 395                 400                 405

 acagtttgta agcctttcaa cagcagcatc aacctacgtg gtggaaatag taaacctata   1434

 ttttcataat tctatgtgta tttttatttt gaataaacag aaagaaattt              1484




      <210> 43
      <211> 1023
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (109)..(846)

      <400> 43
 cggctggtac cccggaagca gtcgctgcaa cttccgggag gtgcttgtgt gcctggtgcg     60

 ggagctacgg ggcccaggga ttgtgtttaa agtagtgctt ctaccaac atg tcc cgt     117
                                                      Met Ser Arg
                                                        1

 ggt tcc agc gcc ggt ttt gac cgc cac att acc att ttt tca ccc gag      165
 Gly Ser Ser Ala Gly Phe Asp Arg His Ile Thr Ile Phe Ser Pro Glu
       5                  10                  15

 ggt cgg ctc tac caa gta gaa tat gct ttt aag gct att aac cag ggt      213
 Gly Arg Leu Tyr Gln Val Glu Tyr Ala Phe Lys Ala Ile Asn Gln Gly
  20                  25                  30                  35

 ggc ctt aca tca gta gct gtc aga ggg aaa gac tgt gca gta att gtc      261
 Gly Leu Thr Ser Val Ala Val Arg Gly Lys Asp Cys Ala Val Ile Val
                  40                  45                  50

 aca cag aag aaa gta cct gac aaa tta ttg gat tcc agc aca gtg act      309
 Thr Gln Lys Lys Val Pro Asp Lys Leu Leu Asp Ser Ser Thr Val Thr
              55                  60                  65

 cac tta ttc aag ata act gaa aac att ggt tgt gtg atg acc gga atg      357
 His Leu Phe Lys Ile Thr Glu Asn Ile Gly Cys Val Met Thr Gly Met
          70                  75                  80

 aca gct gac agc aga tcc cag gta cag agg gca cgc tat gag gca gct      405
 Thr Ala Asp Ser Arg Ser Gln Val Gln Arg Ala Arg Tyr Glu Ala Ala
      85                  90                  95

 aac tgg aaa tac aag tat ggc tat gag att cct gtg gac atg ctg tgt      453
 Asn Trp Lys Tyr Lys Tyr Gly Tyr Glu Ile Pro Val Asp Met Leu Cys
 100                 105                 110                 115

 aaa aga att gcc gat att tct cag gtc tac aca cag aat gct gaa atg      501
 Lys Arg Ile Ala Asp Ile Ser Gln Val Tyr Thr Gln Asn Ala Glu Met
                 120                 125                 130

 agg cct ctt ggt tgt tgt atg att tta att ggt ata gat gaa gag caa      549
 Arg Pro Leu Gly Cys Cys Met Ile Leu Ile Gly Ile Asp Glu Glu Gln
             135                 140                 145

 ggc cct cag gta tat aag tgt gat cct gca ggt tac tac tgt ggg ttt      597
 Gly Pro Gln Val Tyr Lys Cys Asp Pro Ala Gly Tyr Tyr Cys Gly Phe
         150                 155                 160

 aaa gcc act gca gcg gga gtt aaa caa act gag tca acc agc ttc ctt      645
 Lys Ala Thr Ala Ala Gly Val Lys Gln Thr Glu Ser Thr Ser Phe Leu
     165                 170                 175

 gaa aaa aaa gtg aag aag aaa ttt gat tgg aca ttt gaa cag aca gtg      693
 Glu Lys Lys Val Lys Lys Lys Phe Asp Trp Thr Phe Glu Gln Thr Val
 180                 185                 190                 195

 gaa act gca att aca tgc ctg tct act gtt cta tca att gat ttc aaa      741
 Glu Thr Ala Ile Thr Cys Leu Ser Thr Val Leu Ser Ile Asp Phe Lys
                 200                 205                 210

 cct tca gaa ata gaa gtt gga gta gtg aca gtt gaa aat cct aaa ttc      789
 Pro Ser Glu Ile Glu Val Gly Val Val Thr Val Glu Asn Pro Lys Phe
             215                 220                 225

 agg att ctt aca gaa gca gag att gat gct cac ctt gtt gct cta gca      837
 Arg Ile Leu Thr Glu Ala Glu Ile Asp Ala His Leu Val Ala Leu Ala
         230                 235                 240

 gag aga gac taaacat tgtcgttagt ttaccagatc cgtgatgcca cttacctgtg      893
 Glu Arg Asp 
     245

 tgtttggtaa caacaaacca acatcatgga ggtccctgga ttgaaaaagg agcctctccc    953

 actcctccta ccaccgaagt ggttaggact ctatataaat aaaaacaagg cttttggaaa   1013

 aaaaaaaaaa                                                          1023




      <210> 44
      <211> 2173
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (311)..(2143)

      <400> 44
 acttgtgttt tggaacagct gcagccggcg ctgggcccgc ctggaatgcg ggaacaggct     60

 gcacaccagg acttttatgg aaacttgctg ctggagacgg cggcggcggc ggcggcagcg    120

 gcagccatag gactcccagc ggctggagca gaagtgttag cggacagagc tcccagaccc    180

 ctacccacag ccaggcggga cgcgcacagt ccctccacgc ggaaagaagt accttcgccg    240

 gtcaccggct cctgcagggt gcaaatatat acagagcttc ataatcagcc caagaccaca    300

 tagagcaaac   atg aat gat att tcc caa aag gct gag att aaa gaa atg     349
              Met Asn Asp Ile Ser Gln Lys Ala Glu Ile Lys Glu Met
                1               5                  10

 ctt gct tct gat gat gag gaa gat gta tct tct aaa gta gaa aag gct      397
 Leu Ala Ser Asp Asp Glu Glu Asp Val Ser Ser Lys Val Glu Lys Ala
      15                  20                  25

 tat gtt cca aaa tta aca gga act gtg aag ggt aga ttt gct gaa atg      445
 Tyr Val Pro Lys Leu Thr Gly Thr Val Lys Gly Arg Phe Ala Glu Met
  30                  35                  40                  45

 gag aaa caa aga caa gag gaa caa agg aag aga acg gag gag gaa cga      493
 Glu Lys Gln Arg Gln Glu Glu Gln Arg Lys Arg Thr Glu Glu Glu Arg
                  50                  55                  60

 aaa cgc aga att gag cag gat atg tta gaa aag agg aaa ata cag cgt      541
 Lys Arg Arg Ile Glu Gln Asp Met Leu Glu Lys Arg Lys Ile Gln Arg
              65                  70                  75

 gaa tta gca aaa agg gct gaa cag att gag gac aaa aac aat acg gga      589
 Glu Leu Ala Lys Arg Ala Glu Gln Ile Glu Asp Lys Asn Asn Thr Gly
          80                  85                  90

 act gaa tca gca tca gag gaa gga gat gat tca cta ctt ata act gtg      637
 Thr Glu Ser Ala Ser Glu Glu Gly Asp Asp Ser Leu Leu Ile Thr Val
      95                 100                 105

 gta cct gtc aaa tca tat aaa aca tct gga aaa atg aaa aag aat ttt      685
 Val Pro Val Lys Ser Tyr Lys Thr Ser Gly Lys Met Lys Lys Asn Phe
 110                 115                 120                 125

 gag gat cta gaa aaa gaa cgt gaa gag aaa gaa agg atc aag tac gag      733
 Glu Asp Leu Glu Lys Glu Arg Glu Glu Lys Glu Arg Ile Lys Tyr Glu
                 130                 135                 140

 gaa gat aaa aga ata aga tat gaa gaa caa cga cca tct ctc aag gaa      781
 Glu Asp Lys Arg Ile Arg Tyr Glu Glu Gln Arg Pro Ser Leu Lys Glu
             145                 150                 155

 gca aag tgt ctt tct tta gtt atg gat gat gaa ata gaa agt gaa gca      829
 Ala Lys Cys Leu Ser Leu Val Met Asp Asp Glu Ile Glu Ser Glu Ala
         160                 165                 170

 aaa aaa gaa tca ctt tct ccc gga aaa ttg aaa cta act ttt gaa gaa      877
 Lys Lys Glu Ser Leu Ser Pro Gly Lys Leu Lys Leu Thr Phe Glu Glu
     175                 180                 185

 ctg gag cga caa aga caa gaa aac cga aag aag caa gct gaa gag gaa      925
 Leu Glu Arg Gln Arg Gln Glu Asn Arg Lys Lys Gln Ala Glu Glu Glu
 190                 195                 200                 205

 gca aga aaa cgt tta gaa gaa gag aag cgt gct ttt gaa gaa gca agg      973
 Ala Arg Lys Arg Leu Glu Glu Glu Lys Arg Ala Phe Glu Glu Ala Arg
                 210                 215                 220

 cgg caa atg gta aat gaa gat gag gaa aac caa gac aca gca aaa att     1021
 Arg Gln Met Val Asn Glu Asp Glu Glu Asn Gln Asp Thr Ala Lys Ile
             225                 230                 235

 ttt aaa ggg tac cgc cct ggt aaa ctc aaa ctc agt ttt gaa gaa atg     1069
 Phe Lys Gly Tyr Arg Pro Gly Lys Leu Lys Leu Ser Phe Glu Glu Met
         240                 245                 250

 gaa agg caa aga aga gaa gat gaa aaa agg aaa gca gaa gaa gaa gcc     1117
 Glu Arg Gln Arg Arg Glu Asp Glu Lys Arg Lys Ala Glu Glu Glu Ala
     255                 260                 265

 aga agg aga ata gag gaa gaa aag aag gcg ttt gct gaa gca agg aga     1165
 Arg Arg Arg Ile Glu Glu Glu Lys Lys Ala Phe Ala Glu Ala Arg Arg
 270                 275                 280                 285

 aat atg gta gta gat gat gac tcc cca gag atg tat aag aca atc tct     1213
 Asn Met Val Val Asp Asp Asp Ser Pro Glu Met Tyr Lys Thr Ile Ser
                 290                 295                 300

 caa gaa ttt ctt aca ccg gga aaa ctg gaa att aat ttt gaa gaa tta     1261
 Gln Glu Phe Leu Thr Pro Gly Lys Leu Glu Ile Asn Phe Glu Glu Leu
             305                 310                 315

 tta aaa caa aaa atg gaa gaa gaa aaa cga cga aca gag gag gaa cgg     1309
 Leu Lys Gln Lys Met Glu Glu Glu Lys Arg Arg Thr Glu Glu Glu Arg
         320                 325                 330

 aag cat aag cta gaa atg gag aaa caa gaa ttt gaa caa ctg aga cag     1357
 Lys His Lys Leu Glu Met Glu Lys Gln Glu Phe Glu Gln Leu Arg Gln
     335                 340                 345

 gaa atg gga gag gaa gag gaa gaa aat gaa acc ttt gga ttg agc aga     1405
 Glu Met Gly Glu Glu Glu Glu Glu Asn Glu Thr Phe Gly Leu Ser Arg
 350                 355                 360                 365

 gaa tat gaa gaa ctg atc aaa tta aaa agg agt ggc tct att caa gct     1453
 Glu Tyr Glu Glu Leu Ile Lys Leu Lys Arg Ser Gly Ser Ile Gln Ala
                 370                 375                 380

 aaa aac cta aaa agc aag ttt gaa aaa att gga cag ttg tct gaa aaa     1501
 Lys Asn Leu Lys Ser Lys Phe Glu Lys Ile Gly Gln Leu Ser Glu Lys
             385                 390                 395

 gaa ata cag aaa aaa ata gaa gaa gag cga gca aga agg aga gca att     1549
 Glu Ile Gln Lys Lys Ile Glu Glu Glu Arg Ala Arg Arg Arg Ala Ile
         400                 405                 410

 gac ctt gaa att aaa gag cga gaa gct gaa aat ttt cat gag gaa gat     1597
 Asp Leu Glu Ile Lys Glu Arg Glu Ala Glu Asn Phe His Glu Glu Asp
     415                 420                 425

 gat gtt gat gtt agg cct gca aga aaa agc gag gct cca ttt act cac     1645
 Asp Val Asp Val Arg Pro Ala Arg Lys Ser Glu Ala Pro Phe Thr His
 430                 435                 440                 445

 aaa gtg aat atg aaa gct aga ttt gaa caa atg gct aag gca aga gaa     1693
 Lys Val Asn Met Lys Ala Arg Phe Glu Gln Met Ala Lys Ala Arg Glu
                 450                 455                 460

 gaa gaa gaa caa aga aga att gaa gaa caa aag tta cta cgc atg cag     1741
 Glu Glu Glu Gln Arg Arg Ile Glu Glu Gln Lys Leu Leu Arg Met Gln
             465                 470                 475

 ttt gaa caa agg gaa att gat gca gca cta caa aag aaa aga gaa gag     1789
 Phe Glu Gln Arg Glu Ile Asp Ala Ala Leu Gln Lys Lys Arg Glu Glu
         480                 485                 490

 gag gag gag gaa gaa ggt agc atc atg aat ggc tcc act gct gaa gat     1837
 Glu Glu Glu Glu Glu Gly Ser Ile Met Asn Gly Ser Thr Ala Glu Asp
     495                 500                 505

 gaa gag caa acc aga tca gga gct cca tgg ttc aag aag cct ctt aaa     1885
 Glu Glu Gln Thr Arg Ser Gly Ala Pro Trp Phe Lys Lys Pro Leu Lys
 510                 515                 520                 525

 aac aca tca gtt gta gac agt gag cca gtc aga ttt acg gtt aaa gta     1933
 Asn Thr Ser Val Val Asp Ser Glu Pro Val Arg Phe Thr Val Lys Val
                 530                 535                 540

 aca gga gaa ccc aaa cca gaa att aca tgg tgg ttt gaa gga gaa ata     1981
 Thr Gly Glu Pro Lys Pro Glu Ile Thr Trp Trp Phe Glu Gly Glu Ile
             545                 550                 555

 ctg cag gat gga gaa gac tat caa tat att gaa agg gga gaa act tac     2029
 Leu Gln Asp Gly Glu Asp Tyr Gln Tyr Ile Glu Arg Gly Glu Thr Tyr
         560                 565                 570

 tgc ctt tac tta cca gaa act ttc cca gaa gat gga gga gag tat atg     2077
 Cys Leu Tyr Leu Pro Glu Thr Phe Pro Glu Asp Gly Gly Glu Tyr Met
     575                 580                 585

 tgt aaa gca gtc aac aat aaa gga tct gca gct agt acc tgt att ctt     2125
 Cys Lys Ala Val Asn Asn Lys Gly Ser Ala Ala Ser Thr Cys Ile Leu
 590                 595                 600                 605

 acc att gaa agt aag aat taatcactct ttttatcttt tattctatta            2173
 Thr Ile Glu Ser Lys Asn 
                 610





      <210> 45
      <211> 929
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (626)..(817)

      <400> 45
 tttgtctgta atggcaatgg caagacctga acttcaactt tatttttctt aaggtgtcat     60

 cacaaagtgt ttgaaggacc aaagatagta cttctaaaat ttgacagggc ttcattttga    120

 ttttttctcc ccaaatagtt gatagcaata atcaatacca gttgagatac caaagaggca    180

 gcctttccct gattgccaca ccacttgtag gcctttgcta gaatggtcat taatacgtat    240

 gaatcagttg agctaaatat tatttagaac gtggcaaaat gctggctgta aattaaatca    300

 aagataagta attcaaaggc tttaactgaa aatttctgaa aagatgtttg ctgtgctatt    360

 aaagatgtta aataacaaaa attaaaagaa ctgagaaaga ctataccatg aaagtgcata    420

 atagtgaaga aaaaaatgaa gttcccttgg cgttagccag gtgcatgcaa atctttttat    480

 ctgaatgtag aaatgcaaaa agtaccagga gaacatttct gaaagtagtc aagtatgttt    540

 taacatttat ctccttataa tatgcaaact gccaaactgg agttatgttt ttagttggta    600

 attgatatat atatatattt ttgag  atg gag ttt cac tcg tcg ccc agg ctg     652
                              Met Glu Phe His Ser Ser Pro Arg Leu
                                1               5

 gag tgc agt ggc acg atc tcg gct cac tgc gac ctc cac ctc ctg ggt      700
 Glu Cys Ser Gly Thr Ile Ser Ala His Cys Asp Leu His Leu Leu Gly
  10                  15                  20                  25

 tca agt gat tct cct gcc tcc acc tcc cga gta gtt ggg acc aca ggc      748
 Ser Ser Asp Ser Pro Ala Ser Thr Ser Arg Val Val Gly Thr Thr Gly
                  30                  35                  40

 gtg tgc cac cat gcc tgg aca gtt ttg ggg ttt ttt tgt att ttt agt      796
 Val Cys His His Ala Trp Thr Val Leu Gly Phe Phe Cys Ile Phe Ser
              45                  50                  55

 gga gac agg gtt ttg cca tct tg accaggctaa tctcgaaccc ctgacctcag      849
 Gly Asp Arg Val Leu Pro Ser 
          60

 gtgatccgcc agccttggcc tcccaaagtg ctgggattat ttgaggtcag gagttagtga    909

 tcagcctggt caacatggtg                                                929




      <210> 46
      <211> 2526
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1549)..(2469)

      <400> 46
 atgagggaat acattgcctc caagcaccga cgggggcttt ccagctcggc cctgccgcgc     60

 ctcaccgagg ccgaaaggag gctgctcaag ggcacggtcg acttctgcgc gctcaaccac    120

 ttcaccacta ggttcgtgat gcacgagcag ctggccggca gccgctacga ctcggacagg    180

 gacatccagt ttctgcagga catcacccgc ctgagctccc ccacgcgcct ggctgtgatt    240

 ccctgggggg tgcgcaagct gctgcggtgg gtccggagga actacggcga catggacatt    300

 tacatcaccg ccagtggcat cgacgaccag gctctggagg atgaccggct ccggaagtac    360

 tacctaggga agtaccttca ggaggtgctg aaagcatacc tgattgataa agtcagaatc    420

 aaaggctatt atgcattcaa actggctgaa gagaaatcta aacccagatt tggattcttc    480

 acatctgatt ttaaagctaa atcctcaata caattttaca acaaagctca ctcgaaagtt    540

 tggcataact acaacacaca tttccgccca catcagaagg gttggttatc gatcacgttg    600

 ggatctcatt ggatcgagcc aaaccggtcg gaaaacacga tggatatatt caaatgtcaa    660

 caatccatgg tttctgtgct tggatggttt gccaacccta tccatgggga tggcgactat    720

 ccagagggga tgagaaagaa gttgttctcc gttctaccca ttttctctga agcagagaag    780

 catgagatga gaggcacagc tgatttcttt gccttttctt ttggacccaa caacttcaag    840

 cccctaaaca ccatggctaa aatgggacaa aatgtttcac ttaatttaag agaagcgctg    900

 aactggatta aactggaata caacaaccct cgaatcttga ttgctgagaa tggctggttc    960

 acagacagtc gtgtgaaaac agaagacacc acggccatct acatgatgaa gaatttcctc   1020

 agccaggtgc ttcaagcaat aaggttagat gaaatacgag tgtttggtta tactgcctgg   1080

 tctctcctgg atggctttga atggcaggat gcttacacca tccgccgagg attattttat   1140

 gtggatttta acagtaaaca gaaagagcgg aaacctaagt cttcagcaca ctactacaaa   1200

 cagatcatac gagaaaatgg tttttcttta aaagagtcca cgccagatgt gcagggccag   1260

 tttccctgtg acttctcctg gggtgtcact gaatctgttc ttaaggttac attgtttctg   1320

 tgtttgaacg tggcagtcaa gaacataaga aatcatggta ttcggctttt acatctgaac   1380

 acaaacgtgt atgagatagc caaaacacta caaaatccac gagtctgcac atgtatctca   1440

 aaagaacctt cgacaactca aagagtgcct gttagggtgt tgcacgattg ctactgcact   1500

 tctcaatgtc tgccgctgaa gcctagcgga cagctcggca agcgccat atg agc ctg    1557
                                                      Met Ser Leu
                                                        1

 gcg gcg cca gat gcg aat cct gtt gtg ggc ttt ttg gcc tat tcc cgc     1605
 Ala Ala Pro Asp Ala Asn Pro Val Val Gly Phe Leu Ala Tyr Ser Arg
       5                  10                  15

 ccc tca gtc ttg ccg gga tgg cac cgc ccg cat agg act tcc agg gtt     1653
 Pro Ser Val Leu Pro Gly Trp His Arg Pro His Arg Thr Ser Arg Val
  20                  25                  30                  35

 ggg ctg agt ggg agt tcg act gct ggg cct cgt aat tct cgc ttt ggg     1701
 Gly Leu Ser Gly Ser Ser Thr Ala Gly Pro Arg Asn Ser Arg Phe Gly
                  40                  45                  50

 gct gct cct tcc agg ctg gga cac act ggg gcc cgc tgt cgg tct ccc     1749
 Ala Ala Pro Ser Arg Leu Gly His Thr Gly Ala Arg Cys Arg Ser Pro
              55                  60                  65

 gtc ctc cga cat ctt gtc tgg aac ttc cgc ctg gca gtc tcc agt agg     1797
 Val Leu Arg His Leu Val Trp Asn Phe Arg Leu Ala Val Ser Ser Arg
          70                  75                  80

 agt gga gct cta atg aag act att ctc agc aat cag act gtc gac att     1845
 Ser Gly Ala Leu Met Lys Thr Ile Leu Ser Asn Gln Thr Val Asp Ile
      85                  90                  95

 cca gaa aat ggt atg aga ctt gat gtc ttt tac tta cat ctt tac tgc     1893
 Pro Glu Asn Gly Met Arg Leu Asp Val Phe Tyr Leu His Leu Tyr Cys
 100                 105                 110                 115

 acg ttc caa gcg ttg tgt ggc ctg acg agt gtg ttc tct ctt cta gtc     1941
 Thr Phe Gln Ala Leu Cys Gly Leu Thr Ser Val Phe Ser Leu Leu Val
                 120                 125                 130

 gac att act ctg aag gga cgc aca gtt atc gtg aag ggc ccc aga gga     1989
 Asp Ile Thr Leu Lys Gly Arg Thr Val Ile Val Lys Gly Pro Arg Gly
             135                 140                 145

 acc ctg cgg agg gac ttc aat cac atc aat gta gaa ctc agc ctt ctt     2037
 Thr Leu Arg Arg Asp Phe Asn His Ile Asn Val Glu Leu Ser Leu Leu
         150                 155                 160

 gga aag aaa aaa aag agg ctc cgg gtt gac aaa tgg tgg ggt aac aga     2085
 Gly Lys Lys Lys Lys Arg Leu Arg Val Asp Lys Trp Trp Gly Asn Arg
     165                 170                 175

 aag gaa ctg gct acc gtt cgg act att tgt agt cat gta cag aac atg     2133
 Lys Glu Leu Ala Thr Val Arg Thr Ile Cys Ser His Val Gln Asn Met
 180                 185                 190                 195

 atc aag ggt gtt aca ctg ggc ttc cgt tac aag atg agg tct gtg tat     2181
 Ile Lys Gly Val Thr Leu Gly Phe Arg Tyr Lys Met Arg Ser Val Tyr
                 200                 205                 210

 gct cac ttc ccc atc aac gtt gtt atc cag gag aat ggg tct ctt gtt     2229
 Ala His Phe Pro Ile Asn Val Val Ile Gln Glu Asn Gly Ser Leu Val
             215                 220                 225

 gaa atc cga aat ttc ttg ggt gaa aaa tat atc cgc agg gtt cgg atg     2277
 Glu Ile Arg Asn Phe Leu Gly Glu Lys Tyr Ile Arg Arg Val Arg Met
         230                 235                 240

 aga cca ggt gtt gct tgt tca gta tct caa gcc cag aaa gat gaa tta     2325
 Arg Pro Gly Val Ala Cys Ser Val Ser Gln Ala Gln Lys Asp Glu Leu
     245                 250                 255

 atc ctt gaa gga aat gac att gag ctt gtt tca aat tca gcg gct ttg     2373
 Ile Leu Glu Gly Asn Asp Ile Glu Leu Val Ser Asn Ser Ala Ala Leu
 260                 265                 270                 275

 att cag caa gcc aca aca gtt aaa aac aag gat atc agg aaa ttt ttg     2421
 Ile Gln Gln Ala Thr Thr Val Lys Asn Lys Asp Ile Arg Lys Phe Leu
                 280                 285                 290

 gat ggt atc tat gtc tct gaa aaa gga act gtt cag cag gct gat gaa     2469
 Asp Gly Ile Tyr Val Ser Glu Lys Gly Thr Val Gln Gln Ala Asp Glu 
             295                 300                 305

 taagatctaa gagttacctg gctacagaaa gaagatgcca gatgacactt aagacct      2526




      <210> 47
      <211> 1326
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (359)..(1015)

      <400> 47
 cagagagacc ctgtgccagt ggagcacact ctcctatcct ggcctggtga aggagctgtg     60

 tgccctcttc attggctctg agctccttcc aaaagatgaa ttaaatgatc tgatcgaccg    120

 agccttcagc agattccgtc acagagaagt ggtccatctg tccaggttga ggaatgggct    180

 gaacgtgttg gagctgtggc atggcgtcac atatgcattt aaggacctgt ccctgtcctg    240

 cacaacacag ttcctgcagt acttcctgga gaagagggag aagcacgtca ctgtggttgt    300

 aggaacatct ggggacacag gaagtgctgc cattgagagt gttcaagggg caaagaac      358                                                                 
 atg gac att atc gtt ctg ctg ccc aaa ggt cac tgc aca aag att cag      406
 Met Asp Ile Ile Val Leu Leu Pro Lys Gly His Cys Thr Lys Ile Gln
   1               5                  10                  15

 gag ctc cag atg aca acg gtg ctg aag cag aac gta cat gtg ttt gga      454
 Glu Leu Gln Met Thr Thr Val Leu Lys Gln Asn Val His Val Phe Gly
              20                  25                  30

 gtg gag gga aac agc gat gag ctc gat gag ccg atc aag act gtg ttt      502
 Val Glu Gly Asn Ser Asp Glu Leu Asp Glu Pro Ile Lys Thr Val Phe
          35                  40                  45

 gcc gat gtg gct ttt gtc aag aag cac aat ctg atg agc ctg aat tcg      550
 Ala Asp Val Ala Phe Val Lys Lys His Asn Leu Met Ser Leu Asn Ser
      50                  55                  60

 atc aac tgg tcc cgg gtc ctg gtg cag atg gcc cat cac ttc ttt gct      598
 Ile Asn Trp Ser Arg Val Leu Val Gln Met Ala His His Phe Phe Ala
  65                  70                  75                  80

 tac ttc cag tgt acg cca tcc ttg gac aca cat ccc cta ccc ctg gtg      646
 Tyr Phe Gln Cys Thr Pro Ser Leu Asp Thr His Pro Leu Pro Leu Val
                  85                  90                  95

 gag gtg gtt gtg cca aca ggg gct gcc ggt aac ctt gca gct ggg tac      694
 Glu Val Val Val Pro Thr Gly Ala Ala Gly Asn Leu Ala Ala Gly Tyr
             100                 105                 110

 att gct caa aag ata ggc ctg ccc atc cgt ctg gtc gtg gca gtg aac      742
 Ile Ala Gln Lys Ile Gly Leu Pro Ile Arg Leu Val Val Ala Val Asn
         115                 120                 125

 cgc aat gac atc atc cac agg act gtc cag cag gga gac ttc tct ctc      790
 Arg Asn Asp Ile Ile His Arg Thr Val Gln Gln Gly Asp Phe Ser Leu
     130                 135                 140

 tct gag gct gtt aaa tca acc ttg gca tca gct atg gac att cag gtg      838
 Ser Glu Ala Val Lys Ser Thr Leu Ala Ser Ala Met Asp Ile Gln Val
 145                 150                 155                 160

 ccc tac aac atg gag agg gtg ttc tgg ctg ctc tct ggc tct gac agc      886
 Pro Tyr Asn Met Glu Arg Val Phe Trp Leu Leu Ser Gly Ser Asp Ser
                 165                 170                 175

 cag gtg aca aga gcc ctc atg gag cag ttt gaa agg acc caa agt gtg      934
 Gln Val Thr Arg Ala Leu Met Glu Gln Phe Glu Arg Thr Gln Ser Val
             180                 185                 190

 aat ctg ccc aag gaa ctg cac agc aag ggg ccc tct tct tct cca agc      982
 Asn Leu Pro Lys Glu Leu His Ser Lys Gly Pro Ser Ser Ser Pro Ser
         195                 200                 205

 agt ggg aga gac agg act acg aaa aaa tgg ctg taatggag tgtgatgggt     1033
 Ser Gly Arg Asp Arg Thr Thr Lys Lys Trp Leu 
     210                 215

 gctgtgtgga actgtgcctt ggaaactgtg ggcccagaag agggagcgtg acagatatcc   1093

 cagggacagc catggtcaga ggtggtggct gagctggcct ccaaccagga ggagcagttt   1153

 gccaggtagc gtcattgtag caataagttc aaggtgccaa ttgtctgtct gtgtctctgt   1213

 cctccatacc cccccatccc taaacttcct ctgtttctta ttcctcctcc accttctcct   1273

 ttcccatctc tctattctct cattggcctc cggctgccac ctgcccccat ccc          1326




      <210> 48
      <211> 1422
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1419)

      <400> 48
  atg agg gca gtg tca ttg ctt gtg ttg gtt ctt ggg gtc aca atg tcc      48
  Met Arg Ala Val Ser Leu Leu Val Leu Val Leu Gly Val Thr Met Ser
    1               5                  10                  15

 tat gta atg cct tgg cct caa act gag aat tac acc atc tac ttc cct       96
 Tyr Val Met Pro Trp Pro Gln Thr Glu Asn Tyr Thr Ile Tyr Phe Pro
              20                  25                  30

 ggt tct gag gcc ttc aaa ctt gga cga gcc ata agc tca ctt ccc agc      144
 Gly Ser Glu Ala Phe Lys Leu Gly Arg Ala Ile Ser Ser Leu Pro Ser
          35                  40                  45

 atc cag tat cca ggg tct tca gct tac aga tgg cct gtt atg gag ctt      192
 Ile Gln Tyr Pro Gly Ser Ser Ala Tyr Arg Trp Pro Val Met Glu Leu
      50                  55                  60

 ctc agc ctc tat aat tac gca agg agg gcc ttg atg ggc aac tta gca      240
 Leu Ser Leu Tyr Asn Tyr Ala Arg Arg Ala Leu Met Gly Asn Leu Ala
  65                  70                  75                  80

 aat gtc att ccc tgg ggg tgg tct gag aag atg acc att gag tat tta      288
 Asn Val Ile Pro Trp Gly Trp Ser Glu Lys Met Thr Ile Glu Tyr Leu
                  85                  90                  95

 aat ccg ggg aca gga gaa ctt tta aac aac agc cga ggc gat gcg cct      336
 Asn Pro Gly Thr Gly Glu Leu Leu Asn Asn Ser Arg Gly Asp Ala Pro
             100                 105                 110

 cat tca gaa cat gtg cac cat cgc cga gta ccc cgc gcc ggc aac gcc      384
 His Ser Glu His Val His His Arg Arg Val Pro Arg Ala Gly Asn Ala
         115                 120                 125

 gcg gcc tcc gac tgc tgt gtg ggc gcc gcg gcg ccg cct ggt caa gat      432
 Ala Ala Ser Asp Cys Cys Val Gly Ala Ala Ala Pro Pro Gly Gln Asp
     130                 135                 140

 cgc cgt ggt ggg gcc agc ggc gtg ggc aag acc ggg agc cgc tgc ccc      480
 Arg Arg Gly Gly Ala Ser Gly Val Gly Lys Thr Gly Ser Arg Cys Pro
 145                 150                 155                 160

 ttg gga gtg ggc tta gcc gtt gtc tac gcc acc cgc ctg ctt cca cag      528
 Leu Gly Val Gly Leu Ala Val Val Tyr Ala Thr Arg Leu Leu Pro Gln
                 165                 170                 175

 acg ggg gaa aca agg atc aag aat ggc cag gca gct ttc tgg gga cac      576
 Thr Gly Glu Thr Arg Ile Lys Asn Gly Gln Ala Ala Phe Trp Gly His
             180                 185                 190

 cgg cac cgc cgc cat cag aac ttt ggg gtg ttt gag cct ctg caa tgc      624
 Arg His Arg Arg His Gln Asn Phe Gly Val Phe Glu Pro Leu Gln Cys
         195                 200                 205

 ctg gca cag aaa ggg gag tta gtg aag cta gcc ccc ctg gga ggt ctt      672
 Leu Ala Gln Lys Gly Glu Leu Val Lys Leu Ala Pro Leu Gly Gly Leu
     210                 215                 220

 gaa gca ctg gtg gtc cgg ttc ctc acc aaa cga ttc atc ggt gac tat      720
 Glu Ala Leu Val Val Arg Phe Leu Thr Lys Arg Phe Ile Gly Asp Tyr
 225                 230                 235                 240

 gaa aga aat gca ggt aat ctc tat act aga caa gtt cag ata gaa ggt      768
 Glu Arg Asn Ala Gly Asn Leu Tyr Thr Arg Gln Val Gln Ile Glu Gly
                 245                 250                 255

 gaa acc ctg gct ctt cag gtt caa gac act cca ggt att cag gtc cat      816
 Glu Thr Leu Ala Leu Gln Val Gln Asp Thr Pro Gly Ile Gln Val His
             260                 265                 270

 gag aac agc ctg agc tgc agt gaa cag ctg aat agg tgc att cgc tgg      864
 Glu Asn Ser Leu Ser Cys Ser Glu Gln Leu Asn Arg Cys Ile Arg Trp
         275                 280                 285

 gca gat gct gtg gtg atc gtt ttc tcc atc act gac tac aag agc tat      912
 Ala Asp Ala Val Val Ile Val Phe Ser Ile Thr Asp Tyr Lys Ser Tyr
     290                 295                 300

 gaa ctc atc agc cag ctc cac cag cac gtg cag cag cta cac ctg ggc      960
 Glu Leu Ile Ser Gln Leu His Gln His Val Gln Gln Leu His Leu Gly
 305                 310                 315                 320

 acc cgg ctg cct gtg gtg gtc gtg gcc aac aaa gct gac ctg ttg cac     1008
 Thr Arg Leu Pro Val Val Val Val Ala Asn Lys Ala Asp Leu Leu His
                 325                 330                 335

 atc aaa cag gtt gac cct cag ctt gga ctg cag cta gcc agc atg cta     1056
 Ile Lys Gln Val Asp Pro Gln Leu Gly Leu Gln Leu Ala Ser Met Leu
             340                 345                 350

 ggc tgc tca ttc tat gaa gtg tct gtc agt gaa aat tat aat gat gtc     1104
 Gly Cys Ser Phe Tyr Glu Val Ser Val Ser Glu Asn Tyr Asn Asp Val
         355                 360                 365

 tac agc gcc ttc cac gtc ctc tgt aaa gag gtc agt cac aaa cag cag     1152
 Tyr Ser Ala Phe His Val Leu Cys Lys Glu Val Ser His Lys Gln Gln
     370                 375                 380

 cct agc agt aca ccc gag aag cga aga acc tcc ctc att ccc agg ccc     1200
 Pro Ser Ser Thr Pro Glu Lys Arg Arg Thr Ser Leu Ile Pro Arg Pro
 385                 390                 395                 400

 aag tca ccc aac atg cag gac ctg aag agg agg ttt aag caa gcc ctc     1248
 Lys Ser Pro Asn Met Gln Asp Leu Lys Arg Arg Phe Lys Gln Ala Leu
                 405                 410                 415

 tct gcc aaa gca tct tat aag cca ttg ttg aag caa gtt gtg gag gaa     1296
 Ser Ala Lys Ala Ser Tyr Lys Pro Leu Leu Lys Gln Val Val Glu Glu
             420                 425                 430

 ata ttt cat ccc gag agg cca gat tcc gtt gat att gaa cac atg tct     1344
 Ile Phe His Pro Glu Arg Pro Asp Ser Val Asp Ile Glu His Met Ser
         435                 440                 445

 tca ggc ctc act gat ctc ctt aaa act gga ttt agc atg ttc atg aag     1392
 Ser Gly Leu Thr Asp Leu Leu Lys Thr Gly Phe Ser Met Phe Met Lys
     450                 455                 460

 tcc aac atc aca gtg cct tta ata cac taa                             1422
 Ser Asn Ile Thr Val Pro Leu Ile His 
 465                 470





      <210> 49
      <211> 680
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (240)..(623)

      <400> 49
 taagcttgcg gccgcgtgag ccgccggagc aggagctgca gcgacgtcgg gagcagaagc     60

 ggcggcgaca cgacgcgcag cagctgcagc agctcaagca cctggagtcc ttttacgaaa    120

 aacctcctcc tgggcttatc aaggaagatg agactaagcc agaagattgc ataccagatg    180

 taccaggcaa tgaacacgcc agggaatttc tggctcatgc accaactaaa ggactttgg     239                                                                 
 atg cca ctg ggg aaa gaa gtc aaa gtt atg cag tgt tgg cgt tgc aaa      287
 Met Pro Leu Gly Lys Glu Val Lys Val Met Gln Cys Trp Arg Cys Lys
   1               5                  10                  15

 cgc tat ggt cac cga acg ggt gac aaa gaa tgc cct ttc ttt atc aaa      335
 Arg Tyr Gly His Arg Thr Gly Asp Lys Glu Cys Pro Phe Phe Ile Lys
              20                  25                  30

 ggc aac caa aag tta gag cag ttc aga gtg gca cat gaa gat ccc atg      383
 Gly Asn Gln Lys Leu Glu Gln Phe Arg Val Ala His Glu Asp Pro Met
          35                  40                  45

 tat gac atc ata cga gac aat aaa cga cat gaa aag gac gta agg ata      431
 Tyr Asp Ile Ile Arg Asp Asn Lys Arg His Glu Lys Asp Val Arg Ile
      50                  55                  60

 cag cag tta aaa cag tta ctg gag gat tct acc tca gat gaa gat agg      479
 Gln Gln Leu Lys Gln Leu Leu Glu Asp Ser Thr Ser Asp Glu Asp Arg
  65                  70                  75                  80

 agc agc tcc agt tcc tct gaa ggt aaa gag aaa cac aag aaa aag aag      527
 Ser Ser Ser Ser Ser Ser Glu Gly Lys Glu Lys His Lys Lys Lys Lys
                  85                  90                  95

 aag aaa gaa aag cat aag aaa agg aag aaa gaa aag aaa aag aag aaa      575
 Lys Lys Glu Lys His Lys Lys Arg Lys Lys Glu Lys Lys Lys Lys Lys
             100                 105                 110

 aaa cgg aag cac aaa tct tcc aag tca aat gag ggt tct gac tca gag      623
 Lys Arg Lys His Lys Ser Ser Lys Ser Asn Glu Gly Ser Asp Ser Glu 
         115                 120                 125

 tgacaaggat gtgacttgtt caacattctc ttctcaaaca ctgaccaagg aacagag       680




      <210> 50
      <211> 3087
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1880)..(2281)

      <400> 50
 atggggtgta caccttcaca cagtgacctt gtaaacagcg ttgcaaagag tggcattcag     60

 ttcttgaaaa agcccaaagc aattcggcca ggatgtcagg gcggaagtga aagaggttcc    120

 atccctttgc tggttaaaaa ctccacctgc tatgacgctg gggagggcct ggcagaggag    180

 cagccaagtc ccaggaggaa ccaaaccaca gctaaaggtc tttgtcagct catgggagat    240

 cctgcttcag gcaaaaggaa agatatggaa ggactgatcc caggaaccaa aacctcttca    300

 tcccagctga acaaatcaca aagccacatg gctaaggata ttccgttcaa gacacagggt    360

 tcccatggat cacaaggggc agacttttct ggagatgaga gtgaggaaag tagtacccaa    420

 gatacttcca aatggaaaag gacagcaaaa tgtcacacgt caagcacaca gagccactgc    480

 taccaaacca tccaccctgc tcatgagcct gaaggcaaag tggacttccc ggagcctctg    540

 gtaaaggccc accagcaggc ttacacctat ctacactcca gcctctccaa atatgaagca    600

 attctgtgca tcatccatca ggccacccag acccgggagc tgctgcagcc catggtcagc    660

 ttcttgctgc tgtgctttga ggagatcagc cagctgttgg gggagatctc caaggatgga    720

 gaagtgctcc tgcaggaagt cagggaggat ctggcttggc ctttgaagaa aagagagccc    780

 caggagcagc caaatctcct gcaacagctg ctacagtaca cagtcagcaa gctgcaggtg    840

 ctcaatggca cagtggcctc gctcaccggc agcttcctgg agggctccag cagctacctc    900

 cactccactg caacccactt ggaaaataag ctgagcacaa aaaggaatgt ggatgaacgc    960

 ctcctgaggg ctctgaggca gctagagagc ctggcgagtg gctgtggcga ccctggggtg   1020

 cagggtctcc ccttatgctc tgaggacagt ggcattggtg ctgacaatga gtccgtgcag   1080

 tcggtggaca agctgggcaa gcaaaccagc tgggaccttg caccagagcc cgaagaatgg   1140

 aagtcggtga cttcacccca cacagaggcc aggcagtcag gacacacctg gcagcaaagt   1200

 ccattctgtt tgggctcagg cagaccccag gactgcctgc tctcaggggc tcctatggca   1260

 aaggttcagc cacgagcaca ggacgaagca aggagcccat gcctctccag tacaagccca   1320

 gaaaatatca cctccccacc tttgaagctg gggacaagca ccccatgtga ttcctttggg   1380

 attggggtct ctgtggaacc acacctttcc aaaacctcca ggccgatgga cgcttcatct   1440

 cttagtgaca gcgaggacag cagcccagag gaggaggagg aagacaaaat gagcagcatg   1500

 agtctgtgtg cctggcagga aaaaactcca cattcaaggc cacaatcttc acctgctgac   1560

 cgggaaagcc catttcaggc ccgcaccagg aggcttagga gcctccaggc ccaggaaatg   1620

 attctgaaga tgaaggagtc aatcagcgaa aggatcaagt ttgtccctgt gccctgtggg   1680

 caccaggact ggtctgagga ggaggagggg aggacagtgg tccccccaag acctagcacg   1740

 gtaagtggca gcaggagggc ccctgagagg cagacgaggt cccagtcaga gtcgtgtctc   1800

 cagagtcacg tggaggaccc cacctttcag gagctgcgaa gggtccagag ggacctcagt   1860

 cagaagctgg aggcatttt atg ccc tgg gtg cca aag ggc agg ggc aga gcc    1912
                      Met Pro Trp Val Pro Lys Gly Arg Gly Arg Ala
                        1               5                  10

 agg agc aaa ttc tgc agc cca gag cag ccg ccg tgt ggc cca atg gca     1960
 Arg Ser Lys Phe Cys Ser Pro Glu Gln Pro Pro Cys Gly Pro Met Ala
              15                  20                  25

 cct gca ggg tca gtc caa gca aca cca cca gca ggc tca agg cat ccc     2008
 Pro Ala Gly Ser Val Gln Ala Thr Pro Pro Ala Gly Ser Arg His Pro
          30                  35                  40

 tca cca aga act tca gta ttt tgc cta gtc agg aca aga gca tct tgc     2056
 Ser Pro Arg Thr Ser Val Phe Cys Leu Val Arg Thr Arg Ala Ser Cys
      45                  50                  55

 aga aat gca atc ccc atc ctg agg acg aac aag gca aag ctg gga agc     2104
 Arg Asn Ala Ile Pro Ile Leu Arg Thr Asn Lys Ala Lys Leu Gly Ser
  60                  65                  70                  75

 ttc caa atg cca tcc cat cag gaa gag cag aag cag cca aga gtg agg     2152
 Phe Gln Met Pro Ser His Gln Glu Glu Gln Lys Gln Pro Arg Val Arg
                  80                  85                  90

 agc tca gct gtg aaa tgg agg gga acc tcg aag cac ctc cct cca ccg     2200
 Ser Ser Ala Val Lys Trp Arg Gly Thr Ser Lys His Leu Pro Pro Pro
              95                 100                 105

 cct atg gaa gtt ctg atg gac aaa tca ttc gct tct ctg gag tcc cca     2248
 Pro Met Glu Val Leu Met Asp Lys Ser Phe Ala Ser Leu Glu Ser Pro
         110                 115                 120

 gaa agc agc aag tcc aca gag aac tcc acc aag tgaaccca ggagccaggg     2299
 Glu Ser Ser Lys Ser Thr Glu Asn Ser Thr Lys 
     125                 130

 ccgggagagg ctggccccac caggagaaca tgggattccc caaagctgag ggcctctgtg   2359

 agccccctgg acttgctgcc cagcaagagc gccgccagcc tgaccaagcc tcacagcaca   2419

 gggccaggga gtggcaggag cagctgccag cccaggaagc cagccctgga cctgagcagc   2479

 ccaccagcca ccagccaaag ccccgaggag gacagcttct gaccgccagc caggtggccg   2539

 accgcagcct cccaccttgg accccaccag cacctcttat gaatcccagc tcggccagaa   2599

 cagtgctggt ggcctcagtt tacccccgga agccgcaagc tgttgagcgg catgtccttc   2659

 ccatcctctg gcacttcctg aacaccgcca ccaggaatgg caccctgcct ggacccagcg   2719

 ggaacatccg cggggtggtg tgccggctgt ccaggagcct ccaggagcac atgggctccc   2779

 gcctgctgga ctttgccgcc agccagccaa agcacgtcct caagacgctc caggaactct   2839

 tagactcaga gtccttggga ggcagccgca aggccactga cagaggggtg gcccctgaca   2899

 gcaagacaac tggcagctca tacccttttc agctggatta aagatggatc tgaaatgggc   2959

 aattattatt tatcttattt ttttgatgga ctattctcct ggttactttc ccccttagag   3019

 ttccagatgt acatggtata ttttgaagta gaaataaaag aattacttat ttttctaaaa   3079

 aaaaaaaa                                                            3087




      <210> 51
      <211> 1832
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1779)

      <400> 51
  atg gag ggc gca ggg ccc cgg ggg gcc ggg ccg gcg cgg cgc cgg gga      48
  Met Glu Gly Ala Gly Pro Arg Gly Ala Gly Pro Ala Arg Arg Arg Gly
    1               5                  10                  15

 gcc ggg ggg ccg ccg tca ccg ctg ctg ccg tcg ctg ctg ctg ctg ctg       96
 Ala Gly Gly Pro Pro Ser Pro Leu Leu Pro Ser Leu Leu Leu Leu Leu
              20                  25                  30

 ctg ctc tgg atg ctg ccg gac acc gtg gcg cct cag gaa ctg aac cct      144
 Leu Leu Trp Met Leu Pro Asp Thr Val Ala Pro Gln Glu Leu Asn Pro
          35                  40                  45

 cgc ggc cgc aac gtg tgc cgt gct ccc ggc tcc cag gtg ccc acg tgc      192
 Arg Gly Arg Asn Val Cys Arg Ala Pro Gly Ser Gln Val Pro Thr Cys
      50                  55                  60

 tgc gct ggc tgg agg cag caa ggg gac gag tgt ggg att gcg gtg tgc      240
 Cys Ala Gly Trp Arg Gln Gln Gly Asp Glu Cys Gly Ile Ala Val Cys
  65                  70                  75                  80

 gaa ggc aac tcc acg tgc tca gag aac gag gtg tgc gtg agg cct ggc      288
 Glu Gly Asn Ser Thr Cys Ser Glu Asn Glu Val Cys Val Arg Pro Gly
                  85                  90                  95

 gag tgc cgc tgc cgc cac ggc tac ttc ggt gcc aac tgc gac acc agt      336
 Glu Cys Arg Cys Arg His Gly Tyr Phe Gly Ala Asn Cys Asp Thr Ser
             100                 105                 110

 gag cgt ggg gtc ggg ccg gta ttg gtc ggt ggg gcg gaa tcc tgg aga      384
 Glu Arg Gly Val Gly Pro Val Leu Val Gly Gly Ala Glu Ser Trp Arg
         115                 120                 125

 gat ggg gcg ggg tcc aag gtg ggg cgg ggt cgg atc cgc ctt cgg ggc      432
 Asp Gly Ala Gly Ser Lys Val Gly Arg Gly Arg Ile Arg Leu Arg Gly
     130                 135                 140

 ggg tcc cca gag gtg gcg gct gga gtg cgg gac gcg ggc agg ttc cgg      480
 Gly Ser Pro Glu Val Ala Ala Gly Val Arg Asp Ala Gly Arg Phe Arg
 145                 150                 155                 160

 ctg gct ggg ggc acc tac tca agc acc ggg gcc ttc cac ccc ctc cgc      528
 Leu Ala Gly Gly Thr Tyr Ser Ser Thr Gly Ala Phe His Pro Leu Arg
                 165                 170                 175

 tcc tcc cct gca gag tgc ccg cgc cag ttc tgg ggc ccc gac tgc aag      576
 Ser Ser Pro Ala Glu Cys Pro Arg Gln Phe Trp Gly Pro Asp Cys Lys
             180                 185                 190

 gag ctg tgt agc tgc cac cca cac ggg cag tgc gag gac gtg aca ggc      624
 Glu Leu Cys Ser Cys His Pro His Gly Gln Cys Glu Asp Val Thr Gly
         195                 200                 205

 cag tgt act tgt cac gcg cgg cgc tgg ggc gcg cgc tgc gag cat gcg      672
 Gln Cys Thr Cys His Ala Arg Arg Trp Gly Ala Arg Cys Glu His Ala
     210                 215                 220

 tgc cag tgc cag cac ggc acg tgc cac ccg cgg agc ggc gcg tgc cgc      720
 Cys Gln Cys Gln His Gly Thr Cys His Pro Arg Ser Gly Ala Cys Arg
 225                 230                 235                 240

 tgt gag ccc ggc tgg tgg ggc gcg cag tgc gcc agc gcg tgc tac tgc      768
 Cys Glu Pro Gly Trp Trp Gly Ala Gln Cys Ala Ser Ala Cys Tyr Cys
                 245                 250                 255

 agc gcc acg tcg cgc tgc gac cca cag acc ggc gcc tgc ctg tgc cac      816
 Ser Ala Thr Ser Arg Cys Asp Pro Gln Thr Gly Ala Cys Leu Cys His
             260                 265                 270

 gca ggc tgg tgg ggc cgc agc tgc aac aac cag tgc gcc tgc aac tcg      864
 Ala Gly Trp Trp Gly Arg Ser Cys Asn Asn Gln Cys Ala Cys Asn Ser
         275                 280                 285

 tct ccc tgc gag cag cag agc ggc cgc tgt cag tgc cgc gag cgt acg      912
 Ser Pro Cys Glu Gln Gln Ser Gly Arg Cys Gln Cys Arg Glu Arg Thr
     290                 295                 300

 ttc ggc gcg cgc tgc gat cgc tac tgc cag tgc ttc cgc ggc cgc tgc      960
 Phe Gly Ala Arg Cys Asp Arg Tyr Cys Gln Cys Phe Arg Gly Arg Cys
 305                 310                 315                 320

 cac cct gtg gac ggc acg tgt gcc tgc gag ccg ggc tac cgc ggc aag     1008
 His Pro Val Asp Gly Thr Cys Ala Cys Glu Pro Gly Tyr Arg Gly Lys
                 325                 330                 335

 tac tgt cgc gag ccg tgc ccc gcc ggc ttc tac ggc ttg ggc tgt cgc     1056
 Tyr Cys Arg Glu Pro Cys Pro Ala Gly Phe Tyr Gly Leu Gly Cys Arg
             340                 345                 350

 cgc cgg tgt ggc cag tgc aag ggc cag cag ccg tgc acg gtg gcc gag     1104
 Arg Arg Cys Gly Gln Cys Lys Gly Gln Gln Pro Cys Thr Val Ala Glu
         355                 360                 365

 ggc cgc tgc ttg acg tgc gag ccc ggc tgg aac gga acc aag tgc gac     1152
 Gly Arg Cys Leu Thr Cys Glu Pro Gly Trp Asn Gly Thr Lys Cys Asp
     370                 375                 380

 cag cct tgc gcc acc ggt ttc tat ggc gag ggc tgc agc cac cgc tgt     1200
 Gln Pro Cys Ala Thr Gly Phe Tyr Gly Glu Gly Cys Ser His Arg Cys
 385                 390                 395                 400

 ccg cca tgc cgc gac ggg cat gcc tgt aac cat gtc acc ggc aag tgt     1248
 Pro Pro Cys Arg Asp Gly His Ala Cys Asn His Val Thr Gly Lys Cys
                 405                 410                 415

 acg cgc tgc aac gcg ggc tgg atc ggc gac cgg tgc gag acc aag tgt     1296
 Thr Arg Cys Asn Ala Gly Trp Ile Gly Asp Arg Cys Glu Thr Lys Cys
             420                 425                 430

 agc aat ggc act tac ggc gag gac tgc gcc ttc gtg tgc gcc gac tgc     1344
 Ser Asn Gly Thr Tyr Gly Glu Asp Cys Ala Phe Val Cys Ala Asp Cys
         435                 440                 445

 ggc agc gga cac tgc gac ttc cag tcg ggg cgc tgc ctg tgc agc cct     1392
 Gly Ser Gly His Cys Asp Phe Gln Ser Gly Arg Cys Leu Cys Ser Pro
     450                 455                 460

 ggc gtc cac ggg ccc cac tgt aac gtg acg tgc ccg ccc gga ctc cac     1440
 Gly Val His Gly Pro His Cys Asn Val Thr Cys Pro Pro Gly Leu His
 465                 470                 475                 480

 ggc gcg gac tgt gct cag gcc tgc agc tgc cac gag gac acg tgc gac     1488
 Gly Ala Asp Cys Ala Gln Ala Cys Ser Cys His Glu Asp Thr Cys Asp
                 485                 490                 495

 ccg gtc act ggt gcc tgc cac cta gaa acc aac cag cgc aag ggc gtg     1536
 Pro Val Thr Gly Ala Cys His Leu Glu Thr Asn Gln Arg Lys Gly Val
             500                 505                 510

 atg ggc gcg ggc gcg ctg ctc gtc ctg ctc gtc tgc ctg ctg ctc tcg     1584
 Met Gly Ala Gly Ala Leu Leu Val Leu Leu Val Cys Leu Leu Leu Ser
         515                 520                 525

 ctg ctc ggc tgc tgc tgc gct tgc cgc ggc aag gac cct acg cgc cga     1632
 Leu Leu Gly Cys Cys Cys Ala Cys Arg Gly Lys Asp Pro Thr Arg Arg
     530                 535                 540

 ccc cgc ccc gca ggg agt ttc gct tgg gag gaa gaa ggc gcc gca ccg     1680
 Pro Arg Pro Ala Gly Ser Phe Ala Trp Glu Glu Glu Gly Ala Ala Pro
 545                 550                 555                 560

 act atg cgg gcg ctt cag tcg cat cag cat gaa gct gcc ccg gat ccc     1728
 Thr Met Arg Ala Leu Gln Ser His Gln His Glu Ala Ala Pro Asp Pro
                 565                 570                 575

 gct ccg gag gca gaa act acc caa agt cgt agt ggc cca cca cga cct     1776
 Ala Pro Glu Ala Glu Thr Thr Gln Ser Arg Ser Gly Pro Pro Arg Pro
             580                 585                 590

 gga taacacactc aactgcagct tcctggagcc accctcaggg ctggagcagc cct      1832
 Gly 






      <210> 52
      <211> 2869
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (253)..(2826)

      <400> 52
 cacgtgacct gtttataaaa atatatatta aaaaagttgt aaaaacatgt gtctgagttg     60

 tttttaggtc cccagacagc ggtgtaggtg ggcatatctg ccctgcgcat cccaggtctc    120

 gggattctcc tgtacctctt atcagattta ttctttcttg caacaaaggg gtagaggctg    180

 gatgccgaca tggtagaatg gaaacagcag tgactacatg gaaggcagag gacctcccat    240

 tcctgtgcag cc    atg gag aag atg tcc cgt gtg acc aca gcc ctg ggt     288
                  Met Glu Lys Met Ser Arg Val Thr Thr Ala Leu Gly
                    1               5                  10

 ggc agc gtg ctg aca ggc cgc acc atg cac tgc cac ctg gat gct ccc      336
 Gly Ser Val Leu Thr Gly Arg Thr Met His Cys His Leu Asp Ala Pro
          15                  20                  25

 gcc aat gcc atc agt gtg tgc cgc gac gca gcc cag gtg gtc gtg gca      384
 Ala Asn Ala Ile Ser Val Cys Arg Asp Ala Ala Gln Val Val Val Ala
      30                  35                  40

 ggc cgt agc atc ttc aag atc tat gcc atc gag gag gaa cag ttc gtg      432
 Gly Arg Ser Ile Phe Lys Ile Tyr Ala Ile Glu Glu Glu Gln Phe Val
  45                  50                  55                  60

 gaa aag ctg aac ctg cgt gtg ggg cgc aag cct tcg ctt aac ctg agc      480
 Glu Lys Leu Asn Leu Arg Val Gly Arg Lys Pro Ser Leu Asn Leu Ser
                  65                  70                  75

 tgt gct gac gtg gtc tgg cac cag atg gat gag aac ctg ctg gcc aca      528
 Cys Ala Asp Val Val Trp His Gln Met Asp Glu Asn Leu Leu Ala Thr
              80                  85                  90

 gca gcc acc aat ggc gtg gtg gtc acg tgg aac ctg ggc cgg cca tcc      576
 Ala Ala Thr Asn Gly Val Val Val Thr Trp Asn Leu Gly Arg Pro Ser
          95                 100                 105

 cgc aac aag cag gac cag ctg ttc aca gaa cac aag cgc acg gta aac      624
 Arg Asn Lys Gln Asp Gln Leu Phe Thr Glu His Lys Arg Thr Val Asn
     110                 115                 120

 aaa gtc tgc ttc cac ccc acc gaa gcc cac gtg ctg ctc agt ggc tcc      672
 Lys Val Cys Phe His Pro Thr Glu Ala His Val Leu Leu Ser Gly Ser
 125                 130                 135                 140

 cag gat ggc ttc atg aag tgc ttt gac ctc cgc aga aag gac tct gtc      720
 Gln Asp Gly Phe Met Lys Cys Phe Asp Leu Arg Arg Lys Asp Ser Val
                 145                 150                 155

 agc acc ttc tcg ggt gag gcc aca gag gca ggg cca cgg gag tgg gcg      768
 Ser Thr Phe Ser Gly Glu Ala Thr Glu Ala Gly Pro Arg Glu Trp Ala
             160                 165                 170

 atg gct ggg tgc gtt cct att ctc cca gtg ctc agc tgc cgc atc ctg      816
 Met Ala Gly Cys Val Pro Ile Leu Pro Val Leu Ser Cys Arg Ile Leu
         175                 180                 185

 agg ctg cac cac agc ttt gct cat gga ccg atg cag gat gca gaa tct      864
 Arg Leu His His Ser Phe Ala His Gly Pro Met Gln Asp Ala Glu Ser
     190                 195                 200

 acg gca aat gac gcc cgg gaa tct tgg gga tgt cca ctc tac cct ctg      912
 Thr Ala Asn Asp Ala Arg Glu Ser Trp Gly Cys Pro Leu Tyr Pro Leu
 205                 210                 215                 220

 ggc ctc tgt tct ggg cca cag gca ggc cag tcg gag agc gtg cgg gac      960
 Gly Leu Cys Ser Gly Pro Gln Ala Gly Gln Ser Glu Ser Val Arg Asp
                 225                 230                 235

 gtg cag ttc agt atc cgg gac tac ttc acc ttc gcc tcc acc ttt gag     1008
 Val Gln Phe Ser Ile Arg Asp Tyr Phe Thr Phe Ala Ser Thr Phe Glu
             240                 245                 250

 aac ggc aat gtg cag ctc tgg gac atc cgg cgt ccc gac cgg tgc gag     1056
 Asn Gly Asn Val Gln Leu Trp Asp Ile Arg Arg Pro Asp Arg Cys Glu
         255                 260                 265

 agg atg ttc aca gcc cac aac gga ccc gtc ttc tgc tgc gac tgg cac     1104
 Arg Met Phe Thr Ala His Asn Gly Pro Val Phe Cys Cys Asp Trp His
     270                 275                 280

 ccc gag gac agg ggc tgg ttg gcc act gga ggg cgc gac aag atg gtg     1152
 Pro Glu Asp Arg Gly Trp Leu Ala Thr Gly Gly Arg Asp Lys Met Val
 285                 290                 295                 300

 aag gtc tgg gac atg acc acg cac cgt gcc aag gag atg cac tgt gtg     1200
 Lys Val Trp Asp Met Thr Thr His Arg Ala Lys Glu Met His Cys Val
                 305                 310                 315

 cag acc atc gcc tcg gtg gcc cgt gtg aag tgg cgg cca gag tgc cgc     1248
 Gln Thr Ile Ala Ser Val Ala Arg Val Lys Trp Arg Pro Glu Cys Arg
             320                 325                 330

 cac cac ctg gcc acg tgc tcc atg atg ggg gac cac aac atc tat gtt     1296
 His His Leu Ala Thr Cys Ser Met Met Gly Asp His Asn Ile Tyr Val
         335                 340                 345

 tgg gac gtg cgc cgg ccc ttc gtg cca gct gcc atg ttt gag gaa cac     1344
 Trp Asp Val Arg Arg Pro Phe Val Pro Ala Ala Met Phe Glu Glu His
     350                 355                 360

 cga gac gtc acc acg gga att gcc tgg cgc cac ccc cac gac ccc tcc     1392
 Arg Asp Val Thr Thr Gly Ile Ala Trp Arg His Pro His Asp Pro Ser
 365                 370                 375                 380

 ttc ctg ctg tct ggc tcc aag gac agc tcg ctg tgc cag cac ctg ttc     1440
 Phe Leu Leu Ser Gly Ser Lys Asp Ser Ser Leu Cys Gln His Leu Phe
                 385                 390                 395

 cgc gac gcc agc cag ccc gtc gag cgc gcc aac cct gag ggc ctc tgc     1488
 Arg Asp Ala Ser Gln Pro Val Glu Arg Ala Asn Pro Glu Gly Leu Cys
             400                 405                 410

 tac ggc ctc ttc ggg gac ctg gcc ttc gcc gcc aag gag agc ctc gtg     1536
 Tyr Gly Leu Phe Gly Asp Leu Ala Phe Ala Ala Lys Glu Ser Leu Val
         415                 420                 425

 gct gcc gag tcg ggg cgc aag ccc tac act ggc gac cgg cgc cac ccc     1584
 Ala Ala Glu Ser Gly Arg Lys Pro Tyr Thr Gly Asp Arg Arg His Pro
     430                 435                 440

 atc ttc ttt aag cgc aag ctg gac cct gcc gag ccc ttc gca ggc ctc     1632
 Ile Phe Phe Lys Arg Lys Leu Asp Pro Ala Glu Pro Phe Ala Gly Leu
 445                 450                 455                 460

 gcc tcc agt gcc ctc agt gtc ttt gag acg gag cca ggt ggc ggc ggc     1680
 Ala Ser Ser Ala Leu Ser Val Phe Glu Thr Glu Pro Gly Gly Gly Gly
                 465                 470                 475

 atg cgc tgg ttt gtg gac aca gct gag cgt tat gcg ctg gct ggc cgg     1728
 Met Arg Trp Phe Val Asp Thr Ala Glu Arg Tyr Ala Leu Ala Gly Arg
             480                 485                 490

 cca ctg gcc gag ctc tgt gac cac aac gca aag gtg gct cga gag ctt     1776
 Pro Leu Ala Glu Leu Cys Asp His Asn Ala Lys Val Ala Arg Glu Leu
         495                 500                 505

 ggc cgc aac cag gtg gcg caa acg tgg acc atg ctg cgg atc atc tac     1824
 Gly Arg Asn Gln Val Ala Gln Thr Trp Thr Met Leu Arg Ile Ile Tyr
     510                 515                 520

 tgc agc cct ggc cta gtg ccc act gca aac ctc aac cac agt gtg ggc     1872
 Cys Ser Pro Gly Leu Val Pro Thr Ala Asn Leu Asn His Ser Val Gly
 525                 530                 535                 540

 aag ggt ggc tcc tgt ggc ctc ccg ctc atg aac agt ttc aac ctg aag     1920
 Lys Gly Gly Ser Cys Gly Leu Pro Leu Met Asn Ser Phe Asn Leu Lys
                 545                 550                 555

 gat atg gcc cca ggg ttg ggc agt gag acg cgg ctg gac cgc agc aaa     1968
 Asp Met Ala Pro Gly Leu Gly Ser Glu Thr Arg Leu Asp Arg Ser Lys
             560                 565                 570

 gga gat gca cgg agc gac aca gtt ctg ctc gac tcc tcg gcc aca ctc     2016
 Gly Asp Ala Arg Ser Asp Thr Val Leu Leu Asp Ser Ser Ala Thr Leu
         575                 580                 585

 atc acc aat gag gat aac gag gaa acc gag ggc agc gac gta cct gcc     2064
 Ile Thr Asn Glu Asp Asn Glu Glu Thr Glu Gly Ser Asp Val Pro Ala
     590                 595                 600

 gac tac ctg ctg ggt gac gtg gaa ggt gag gag gac gag ctg tac ctg     2112
 Asp Tyr Leu Leu Gly Asp Val Glu Gly Glu Glu Asp Glu Leu Tyr Leu
 605                 610                 615                 620

 ctg gat ccg gaa cac gcg cac ccc gag gac cct gag tgc gtg ctg ccg     2160
 Leu Asp Pro Glu His Ala His Pro Glu Asp Pro Glu Cys Val Leu Pro
                 625                 630                 635

 cag gag gcc ttt ccg ctg cgc cac gag atc gtg gac acg cct ccc ggg     2208
 Gln Glu Ala Phe Pro Leu Arg His Glu Ile Val Asp Thr Pro Pro Gly
             640                 645                 650

 ccc gag cac ctg cag gac aag gcc gac tcc ccg cac gtg agc ggc agc     2256
 Pro Glu His Leu Gln Asp Lys Ala Asp Ser Pro His Val Ser Gly Ser
         655                 660                 665

 gag gcg gat gtg gcc tcc ctg gcc ccc gtg gac tcc tcc ttc tcg ctc     2304
 Glu Ala Asp Val Ala Ser Leu Ala Pro Val Asp Ser Ser Phe Ser Leu
     670                 675                 680

 ctg tct gtc tca cac gcg ctc tac gac agc cgc ctg ccg ccc gac ttc     2352
 Leu Ser Val Ser His Ala Leu Tyr Asp Ser Arg Leu Pro Pro Asp Phe
 685                 690                 695                 700

 ttc ggc gtg ctg gtg cgc gac atg ctg cac ttc tac gct gag cag ggc     2400
 Phe Gly Val Leu Val Arg Asp Met Leu His Phe Tyr Ala Glu Gln Gly
                 705                 710                 715

 gac gtg cag atg gct gtg tct gtg ctc atc gtc ctg ggt gaa cgg gtg     2448
 Asp Val Gln Met Ala Val Ser Val Leu Ile Val Leu Gly Glu Arg Val
             720                 725                 730

 cgc aag gac atc gac gag cag acc cag gag cac tgg tac act tcc tac     2496
 Arg Lys Asp Ile Asp Glu Gln Thr Gln Glu His Trp Tyr Thr Ser Tyr
         735                 740                 745

 atc gac ctg ctg cag cgc ttc cgc ctc tgg aac gtg tcc aac gag gtg     2544
 Ile Asp Leu Leu Gln Arg Phe Arg Leu Trp Asn Val Ser Asn Glu Val
     750                 755                 760

 gtc aag ctg agc acc agc cgc gcc gtc agc tgc ctc aac cag gcc tcc     2592
 Val Lys Leu Ser Thr Ser Arg Ala Val Ser Cys Leu Asn Gln Ala Ser
 765                 770                 775                 780

 acc acc ctg cac gtc aac tgc agc cac tgc aag cgg ccc atg agc agc     2640
 Thr Thr Leu His Val Asn Cys Ser His Cys Lys Arg Pro Met Ser Ser
                 785                 790                 795

 cgg ggc tgg gtc tgc gac agg tgc cac cgc tgc gcc agc atg tgt gcc     2688
 Arg Gly Trp Val Cys Asp Arg Cys His Arg Cys Ala Ser Met Cys Ala
             800                 805                 810

 gtc tgc cac cac gta gtc aag ggt ctc ttc gtg tgg tgc cag ggc tgc     2736
 Val Cys His His Val Val Lys Gly Leu Phe Val Trp Cys Gln Gly Cys
         815                 820                 825

 agc cac ggc ggc cac ctg cag cac atc atg aag tgg ctg gaa ggc agc     2784
 Ser His Gly Gly His Leu Gln His Ile Met Lys Trp Leu Glu Gly Ser
     830                 835                 840

 tcc cac tgt ccc gca ggc tgc ggc cac ctc tgc gag tac tcc tgacggg     2833
 Ser His Cys Pro Ala Gly Cys Gly His Leu Cys Glu Tyr Ser 
 845                 850                 855

 gcatctgctg ggcttgcccg ggcggccgca agctta                             2869




      <210> 53
      <211> 2665
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (253)..(2622)

      <400> 53
 cacgtgacct gtttataaaa atatatatta aaaaagttgt aaaaacatgt gtctgagttg     60

 tttttaggtc cccagacagc ggtgtaggtg ggcatatctg ccctgcgcat cccaggtctc    120

 gggattctcc tgtacctctt atcagattta ttctttcttg caacaaaggg gtagaggctg    180

 gatgccgaca tggtagaatg gaaacagcag tgactacatg gaaggcagag gacctcccat    240

 tcctgtgcag cc    atg gag aag atg tcc cgt gtg acc aca gcc ctg ggt     288
                  Met Glu Lys Met Ser Arg Val Thr Thr Ala Leu Gly
                    1               5                  10

 ggc agc gtg ctg aca ggc cgc acc atg cac tgc cac ctg gat gct ccc      336
 Gly Ser Val Leu Thr Gly Arg Thr Met His Cys His Leu Asp Ala Pro
          15                  20                  25

 gcc aat gcc atc agt gtg tgc cgc gac gca gcc cag gtg gtc gtg gca      384
 Ala Asn Ala Ile Ser Val Cys Arg Asp Ala Ala Gln Val Val Val Ala
      30                  35                  40

 ggc cgt agc atc ttc aag atc tat gcc atc gag gag gaa cag ttc gtg      432
 Gly Arg Ser Ile Phe Lys Ile Tyr Ala Ile Glu Glu Glu Gln Phe Val
  45                  50                  55                  60

 gaa aag ctg aac ctg cgt gtg ggg cgc aag cct tcg ctt aac ctg agc      480
 Glu Lys Leu Asn Leu Arg Val Gly Arg Lys Pro Ser Leu Asn Leu Ser
                  65                  70                  75

 tgt gct gac gtg gtc tgg cac cag atg gat gag aac ctg ctg gcc aca      528
 Cys Ala Asp Val Val Trp His Gln Met Asp Glu Asn Leu Leu Ala Thr
              80                  85                  90

 gca gcc acc aat ggc gtg gtg gtc acg tgg aac ctg ggc cgg cca tcc      576
 Ala Ala Thr Asn Gly Val Val Val Thr Trp Asn Leu Gly Arg Pro Ser
          95                 100                 105

 cgc aac aag cag gac cag ctg ttc aca gaa cac aag cgc acg gta aac      624
 Arg Asn Lys Gln Asp Gln Leu Phe Thr Glu His Lys Arg Thr Val Asn
     110                 115                 120

 aaa gtc tgc ttc cac ccc acc gaa gcc cac gtg ctg ctc agt ggc tcc      672
 Lys Val Cys Phe His Pro Thr Glu Ala His Val Leu Leu Ser Gly Ser
 125                 130                 135                 140

 cag gat ggc ttc atg aag tgc ttt gac ctc cgc aga aag gac tct gtc      720
 Gln Asp Gly Phe Met Lys Cys Phe Asp Leu Arg Arg Lys Asp Ser Val
                 145                 150                 155

 agc acc ttc tcg ggc cag tcg gag agc gtg cgg gac gtg cag ttc agt      768
 Ser Thr Phe Ser Gly Gln Ser Glu Ser Val Arg Asp Val Gln Phe Ser
             160                 165                 170

 atc cgg gac tac ttc acc ttc gcc tcc acc ttt gag aac ggc aat gtg      816
 Ile Arg Asp Tyr Phe Thr Phe Ala Ser Thr Phe Glu Asn Gly Asn Val
         175                 180                 185

 cag ctc tgg gac atc cgg cgt ccc gac cgg tgc gag agg atg ttc aca      864
 Gln Leu Trp Asp Ile Arg Arg Pro Asp Arg Cys Glu Arg Met Phe Thr
     190                 195                 200

 gcc cac aac gga ccc gtc ttc tgc tgc gac tgg cac ccc gag gac agg      912
 Ala His Asn Gly Pro Val Phe Cys Cys Asp Trp His Pro Glu Asp Arg
 205                 210                 215                 220

 ggc tgg ttg gcc act gga ggg cgc gac aag atg gtg aag gtc tgg gac      960
 Gly Trp Leu Ala Thr Gly Gly Arg Asp Lys Met Val Lys Val Trp Asp
                 225                 230                 235

 atg acc acg cac cgt gcc aag gag atg cac tgt gtg cag acc atc gcc     1008
 Met Thr Thr His Arg Ala Lys Glu Met His Cys Val Gln Thr Ile Ala
             240                 245                 250

 tcg gtg gcc cgt gtg aag tgg cgg cca gag tgc cgc cac cac ctg gcc     1056
 Ser Val Ala Arg Val Lys Trp Arg Pro Glu Cys Arg His His Leu Ala
         255                 260                 265

 acg tgc tcc atg atg ggg gac cac aac atc tat gtt tgg gac gtg cgc     1104
 Thr Cys Ser Met Met Gly Asp His Asn Ile Tyr Val Trp Asp Val Arg
     270                 275                 280

 cgg ccc ttc gtg cca gct gcc atg ttt gag gaa cac cga gac gtc acc     1152
 Arg Pro Phe Val Pro Ala Ala Met Phe Glu Glu His Arg Asp Val Thr
 285                 290                 295                 300

 acg gga att gcc tgg cgc cac ccc cac gac ccc tcc ttc ctg ctg tct     1200
 Thr Gly Ile Ala Trp Arg His Pro His Asp Pro Ser Phe Leu Leu Ser
                 305                 310                 315

 ggc tcc aag gac agc tcg ctg tgc cag cac ctg ttc cgc gac gcc agc     1248
 Gly Ser Lys Asp Ser Ser Leu Cys Gln His Leu Phe Arg Asp Ala Ser
             320                 325                 330

 cag ccc gtc gag cgc gcc aac cct gag ggc ctc tgc tac ggc ctc ttc     1296
 Gln Pro Val Glu Arg Ala Asn Pro Glu Gly Leu Cys Tyr Gly Leu Phe
         335                 340                 345

 ggg gac ctg gcc ttc gcc gcc aag gag agc ctc gtg gct gcc gag tcg     1344
 Gly Asp Leu Ala Phe Ala Ala Lys Glu Ser Leu Val Ala Ala Glu Ser
     350                 355                 360

 ggg cgc aag ccc tac act ggc gac cgg cgc cac ccc atc ttc ttt aag     1392
 Gly Arg Lys Pro Tyr Thr Gly Asp Arg Arg His Pro Ile Phe Phe Lys
 365                 370                 375                 380

 cgc aag ctg gac cct gcc gag ccc ttc gca ggc ctc gcc tcc agt gcc     1440
 Arg Lys Leu Asp Pro Ala Glu Pro Phe Ala Gly Leu Ala Ser Ser Ala
                 385                 390                 395

 ctc agt gtc ttt gag acg gag cca ggt ggc ggc ggc atg cgc tgg ttt     1488
 Leu Ser Val Phe Glu Thr Glu Pro Gly Gly Gly Gly Met Arg Trp Phe
             400                 405                 410

 gtg gac aca gct gag cgt tat gcg ctg gct ggc cgg cca ctg gcc gag     1536
 Val Asp Thr Ala Glu Arg Tyr Ala Leu Ala Gly Arg Pro Leu Ala Glu
         415                 420                 425

 ctc tgt gac cac aac gca aag gtg gct cga gag ctt ggc cgc aac cag     1584
 Leu Cys Asp His Asn Ala Lys Val Ala Arg Glu Leu Gly Arg Asn Gln
     430                 435                 440

 gtg gcg caa acg tgg acc atg ctg cgg atc atc tac tgc agc cct ggc     1632
 Val Ala Gln Thr Trp Thr Met Leu Arg Ile Ile Tyr Cys Ser Pro Gly
 445                 450                 455                 460

 cta gtg ccc act gca aac ctc aac cac agt gtg ggc aag ggt ggc tcc     1680
 Leu Val Pro Thr Ala Asn Leu Asn His Ser Val Gly Lys Gly Gly Ser
                 465                 470                 475

 tgt ggc ctc ccg ctc atg aac agt ttc aac ctg aag gat atg gcc cca     1728
 Cys Gly Leu Pro Leu Met Asn Ser Phe Asn Leu Lys Asp Met Ala Pro
             480                 485                 490

 ggg ttg ggc agt gag acg cgg ctg gac cgc agc aaa gga gat gca cgg     1776
 Gly Leu Gly Ser Glu Thr Arg Leu Asp Arg Ser Lys Gly Asp Ala Arg
         495                 500                 505

 agc gac aca gtt ctg ctc gac tcc tcg gcc aca ctc atc acc aat gag     1824
 Ser Asp Thr Val Leu Leu Asp Ser Ser Ala Thr Leu Ile Thr Asn Glu
     510                 515                 520

 gat aac gag gaa acc gag ggc agc gac gta cct gcc gac tac ctg ctg     1872
 Asp Asn Glu Glu Thr Glu Gly Ser Asp Val Pro Ala Asp Tyr Leu Leu
 525                 530                 535                 540

 ggt gac gtg gaa ggt gag gag gac gag ctg tac ctg ctg gat ccg gaa     1920
 Gly Asp Val Glu Gly Glu Glu Asp Glu Leu Tyr Leu Leu Asp Pro Glu
                 545                 550                 555

 cac gcg cac ccc gag gac cct gag tgc gtg ctg ccg cag gag gcc ttt     1968
 His Ala His Pro Glu Asp Pro Glu Cys Val Leu Pro Gln Glu Ala Phe
             560                 565                 570

 ccg ctg cgc cac gag atc gtg gac acg cct ccc ggg ccc gag cac ctg     2016
 Pro Leu Arg His Glu Ile Val Asp Thr Pro Pro Gly Pro Glu His Leu
         575                 580                 585

 cag gac aag gcc gac tcc ccg cac gtg agc ggc agc gag gcg gat gtg     2064
 Gln Asp Lys Ala Asp Ser Pro His Val Ser Gly Ser Glu Ala Asp Val
     590                 595                 600

 gcc tcc ctg gcc ccc gtg gac tcc tcc ttc tcg ctc ctg tct gtc tca     2112
 Ala Ser Leu Ala Pro Val Asp Ser Ser Phe Ser Leu Leu Ser Val Ser
 605                 610                 615                 620

 cac gcg ctc tac gac agc cgc ctg ccg ccc gac ttc ttc ggc gtg ctg     2160
 His Ala Leu Tyr Asp Ser Arg Leu Pro Pro Asp Phe Phe Gly Val Leu
                 625                 630                 635

 gtg cgc gac atg ctg cac ttc tac gct gag cag ggc gac gtg cag atg     2208
 Val Arg Asp Met Leu His Phe Tyr Ala Glu Gln Gly Asp Val Gln Met
             640                 645                 650

 gct gtg tct gtg ctc atc gtc ctg ggt gaa cgg gtg cgc aag gac atc     2256
 Ala Val Ser Val Leu Ile Val Leu Gly Glu Arg Val Arg Lys Asp Ile
         655                 660                 665

 gac gag cag acc cag gag cac tgg tac act tcc tac atc gac ctg ctg     2304
 Asp Glu Gln Thr Gln Glu His Trp Tyr Thr Ser Tyr Ile Asp Leu Leu
     670                 675                 680

 cag cgc ttc cgc ctc tgg aac gtg tcc aac gag gtg gtc aag ctg agc     2352
 Gln Arg Phe Arg Leu Trp Asn Val Ser Asn Glu Val Val Lys Leu Ser
 685                 690                 695                 700

 acc agc cgc gcc gtc agc tgc ctc aac cag gcc tcc acc acc ctg cac     2400
 Thr Ser Arg Ala Val Ser Cys Leu Asn Gln Ala Ser Thr Thr Leu His
                 705                 710                 715

 gtc aac tgc agc cac tgc aag cgg ccc atg agc agc cgg ggc tgg gtc     2448
 Val Asn Cys Ser His Cys Lys Arg Pro Met Ser Ser Arg Gly Trp Val
             720                 725                 730

 tgc gac agg tgc cac cgc tgc gcc agc atg tgt gcc gtc tgc cac cac     2496
 Cys Asp Arg Cys His Arg Cys Ala Ser Met Cys Ala Val Cys His His
         735                 740                 745

 gta gtc aag ggt ctc ttc gtg tgg tgc cag ggc tgc agc cac ggc ggc     2544
 Val Val Lys Gly Leu Phe Val Trp Cys Gln Gly Cys Ser His Gly Gly
     750                 755                 760

 cac ctg cag cac atc atg aag tgg ctg gaa ggc agc tcc cac tgt ccc     2592
 His Leu Gln His Ile Met Lys Trp Leu Glu Gly Ser Ser His Cys Pro
 765                 770                 775                 780

 gca ggc tgc ggc cac ctc tgc gag tac tcc t gacggggcat ctgctgggct     2643
 Ala Gly Cys Gly His Leu Cys Glu Tyr Ser 
                 785                 790

 tgcccgggcg gccgcaagct ta                                            2665




      <210> 54
      <211> 6324
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3570)

      <400> 54
  atg gag gtg gac acc gag gag aag cgg cat cgc acg cgg tcc aaa ggg      48
  Met Glu Val Asp Thr Glu Glu Lys Arg His Arg Thr Arg Ser Lys Gly
    1               5                  10                  15

 gtt cga gtt ccc gtg gaa cca gcc ata caa gag ctg ttc agc tgt ccc       96
 Val Arg Val Pro Val Glu Pro Ala Ile Gln Glu Leu Phe Ser Cys Pro
              20                  25                  30

 acc cct ggc tgt gac ggc agt ggt cat gtc agt ggc aaa tat gca aga      144
 Thr Pro Gly Cys Asp Gly Ser Gly His Val Ser Gly Lys Tyr Ala Arg
          35                  40                  45

 cac aga agt gta tat ggt tgt ccc ttg gcg aaa aaa aga aaa aca caa      192
 His Arg Ser Val Tyr Gly Cys Pro Leu Ala Lys Lys Arg Lys Thr Gln
      50                  55                  60

 gat aaa cag ccc cag gaa cct gct cct aaa cga aag cca ttt gcc gtg      240
 Asp Lys Gln Pro Gln Glu Pro Ala Pro Lys Arg Lys Pro Phe Ala Val
  65                  70                  75                  80

 aaa gca gac agc tcc tca gtg gat gag tgt gac gac agt gat ggg act      288
 Lys Ala Asp Ser Ser Ser Val Asp Glu Cys Asp Asp Ser Asp Gly Thr
                  85                  90                  95

 gag gac atg gat gag aag gag gag gat gag ggg gag gag tac tcc gag      336
 Glu Asp Met Asp Glu Lys Glu Glu Asp Glu Gly Glu Glu Tyr Ser Glu
             100                 105                 110

 gac aat gac gag cca ggg gat gag gac gag gag gac gag gag ggg gac      384
 Asp Asn Asp Glu Pro Gly Asp Glu Asp Glu Glu Asp Glu Glu Gly Asp
         115                 120                 125

 cgg gag gag gag gag gag atc gag gag gag gat gag gac gat gac gag      432
 Arg Glu Glu Glu Glu Glu Ile Glu Glu Glu Asp Glu Asp Asp Asp Glu
     130                 135                 140

 gat gga gaa gat gtg gag gat gaa gaa gag gaa gag gag gag gag gag      480
 Asp Gly Glu Asp Val Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu
 145                 150                 155                 160

 gag gag gaa gag gaa gaa gaa aac gaa gac cat caa atg aat tgt cac      528
 Glu Glu Glu Glu Glu Glu Glu Asn Glu Asp His Gln Met Asn Cys His
                 165                 170                 175

 aat act cga ata atg caa gac aca gaa aag gat gat aac aat aat gac      576
 Asn Thr Arg Ile Met Gln Asp Thr Glu Lys Asp Asp Asn Asn Asn Asp
             180                 185                 190

 gaa tat gac aat tac gat gaa ctg gtg gcc aag tca ttg tta aac ctc      624
 Glu Tyr Asp Asn Tyr Asp Glu Leu Val Ala Lys Ser Leu Leu Asn Leu
         195                 200                 205

 ggc aaa atc gct gag gat gca gcc tac cgg gcc agg act gag tca gaa      672
 Gly Lys Ile Ala Glu Asp Ala Ala Tyr Arg Ala Arg Thr Glu Ser Glu
     210                 215                 220

 atg aac agc aat acc tcc aat agt ctg gaa gac gat agt gac aaa aac      720
 Met Asn Ser Asn Thr Ser Asn Ser Leu Glu Asp Asp Ser Asp Lys Asn
 225                 230                 235                 240

 gaa aac ctg ggt cgg aaa agt gag ttg agt tta gac tta gac agt gat      768
 Glu Asn Leu Gly Arg Lys Ser Glu Leu Ser Leu Asp Leu Asp Ser Asp
                 245                 250                 255

 gtt gtt aga gaa aca gtg gac tcc ctt aaa cta tta gcc caa gga cac      816
 Val Val Arg Glu Thr Val Asp Ser Leu Lys Leu Leu Ala Gln Gly His
             260                 265                 270

 ggt gtt gtg ctc tca gaa aac atg aat gac aga aat tat gca gac agc      864
 Gly Val Val Leu Ser Glu Asn Met Asn Asp Arg Asn Tyr Ala Asp Ser
         275                 280                 285

 atg tcg cag caa gac agt aga aat atg aat tac gtc atg ttg ggg aag      912
 Met Ser Gln Gln Asp Ser Arg Asn Met Asn Tyr Val Met Leu Gly Lys
     290                 295                 300

 ccc atg aac aac gga ctc atg gaa aag atg gtg gag gag agc gat gag      960
 Pro Met Asn Asn Gly Leu Met Glu Lys Met Val Glu Glu Ser Asp Glu
 305                 310                 315                 320

 gag gtg tgt ctg agc agt ctg gag tgt ttg agg aat cag tgc ttc gac     1008
 Glu Val Cys Leu Ser Ser Leu Glu Cys Leu Arg Asn Gln Cys Phe Asp
                 325                 330                 335

 ctg gcc agg aag ctc agt gag acc aac ccg cag gag agg aat ccg cag     1056
 Leu Ala Arg Lys Leu Ser Glu Thr Asn Pro Gln Glu Arg Asn Pro Gln
             340                 345                 350

 cag aac atg aac atc cgt cag cat gtc cgg cca gaa gag gac ttc cca     1104
 Gln Asn Met Asn Ile Arg Gln His Val Arg Pro Glu Glu Asp Phe Pro
         355                 360                 365

 gga agg acg ccg gac aga aac tac tcg gac atg ctg aac ctc atg cgg     1152
 Gly Arg Thr Pro Asp Arg Asn Tyr Ser Asp Met Leu Asn Leu Met Arg
     370                 375                 380

 ctg gag gag cag ttg agc ccc cgg tcg aga gtg ttt gcc agc tgt gcg     1200
 Leu Glu Glu Gln Leu Ser Pro Arg Ser Arg Val Phe Ala Ser Cys Ala
 385                 390                 395                 400

 aag gag gat ggg tgt cat gag cgg gac gac gat acc acc tct gtg aac     1248
 Lys Glu Asp Gly Cys His Glu Arg Asp Asp Asp Thr Thr Ser Val Asn
                 405                 410                 415

 tcg gac agg tct gaa gag gtg ttc gac atg acc aag ggg aac ctg acc     1296
 Ser Asp Arg Ser Glu Glu Val Phe Asp Met Thr Lys Gly Asn Leu Thr
             420                 425                 430

 ctg ctg gag aaa gcc atc gct ttg gaa acg gaa aga gca aag gcc atg     1344
 Leu Leu Glu Lys Ala Ile Ala Leu Glu Thr Glu Arg Ala Lys Ala Met
         435                 440                 445

 agg gag aag atg gcc atg gaa gct ggg agg agg gac aat atg agg tca     1392
 Arg Glu Lys Met Ala Met Glu Ala Gly Arg Arg Asp Asn Met Arg Ser
     450                 455                 460

 tat gag gac cag tct ccg aga caa ctt ccc ggg gag gac aga aag cct     1440
 Tyr Glu Asp Gln Ser Pro Arg Gln Leu Pro Gly Glu Asp Arg Lys Pro
 465                 470                 475                 480

 aaa tcc agt gac agc cat gtc aaa aag cca tac tat gat ccc tca aga     1488
 Lys Ser Ser Asp Ser His Val Lys Lys Pro Tyr Tyr Asp Pro Ser Arg
                 485                 490                 495

 aca gaa aag aaa gag agc aag tgt cca acc ccc ggg tgt gat gga acc     1536
 Thr Glu Lys Lys Glu Ser Lys Cys Pro Thr Pro Gly Cys Asp Gly Thr
             500                 505                 510

 ggc cac gta act ggg ctg tac cca cat cac cgc agc ctg tcc gga tgc     1584
 Gly His Val Thr Gly Leu Tyr Pro His His Arg Ser Leu Ser Gly Cys
         515                 520                 525

 ccg cac aaa gat agg gtc cct cca gaa atc ctt gcc atg cat gaa agt     1632
 Pro His Lys Asp Arg Val Pro Pro Glu Ile Leu Ala Met His Glu Ser
     530                 535                 540

 gtc ctc aag tgc ccc act ccg ggc tgc acg ggg cgc ggg cat gtc aac     1680
 Val Leu Lys Cys Pro Thr Pro Gly Cys Thr Gly Arg Gly His Val Asn
 545                 550                 555                 560

 agc aac agg aac tcc cac cga agc ctc tcc gga tgc ccg atc gct gca     1728
 Ser Asn Arg Asn Ser His Arg Ser Leu Ser Gly Cys Pro Ile Ala Ala
                 565                 570                 575

 gca gag aaa ctg gcc aag gca cag gaa aag cac cag agc tgc gac gtg     1776
 Ala Glu Lys Leu Ala Lys Ala Gln Glu Lys His Gln Ser Cys Asp Val
             580                 585                 590

 tcc aag tcc agc cag gcc tcg gac cgc gtg ctc agg cca atg tgc ttt     1824
 Ser Lys Ser Ser Gln Ala Ser Asp Arg Val Leu Arg Pro Met Cys Phe
         595                 600                 605

 gtg aag cag ctg gag att cct cag tat ggc tac aga aac aat gtc ccc     1872
 Val Lys Gln Leu Glu Ile Pro Gln Tyr Gly Tyr Arg Asn Asn Val Pro
     610                 615                 620

 aca act acg ccg cgt tcc aac ctg gcc aag gag ctc gag aaa tat tcc     1920
 Thr Thr Thr Pro Arg Ser Asn Leu Ala Lys Glu Leu Glu Lys Tyr Ser
 625                 630                 635                 640

 aag acc tcg ttt gaa tac aac agt tac gac aac cat act tat ggc aag     1968
 Lys Thr Ser Phe Glu Tyr Asn Ser Tyr Asp Asn His Thr Tyr Gly Lys
                 645                 650                 655

 cga gcc ata gct ccc aag gtg caa acc agg gat ata tcc ccc aaa gga     2016
 Arg Ala Ile Ala Pro Lys Val Gln Thr Arg Asp Ile Ser Pro Lys Gly
             660                 665                 670

 tat gat gat gcg aag cgg tac tgc aag gac ccc agc ccc agc agc agc     2064
 Tyr Asp Asp Ala Lys Arg Tyr Cys Lys Asp Pro Ser Pro Ser Ser Ser
         675                 680                 685

 agc acc agc agc tac gcg ccc agc agc agc agc aac ctg agc tgc ggc     2112
 Ser Thr Ser Ser Tyr Ala Pro Ser Ser Ser Ser Asn Leu Ser Cys Gly
     690                 695                 700

 ggg ggc agc agc gcc agc agc acg tgc agc aag agc agc ttc gac tac     2160
 Gly Gly Ser Ser Ala Ser Ser Thr Cys Ser Lys Ser Ser Phe Asp Tyr
 705                 710                 715                 720

 acg cac gac atg gag gcg gcc cac atg gcg gcc acc gcc atc ctc aac     2208
 Thr His Asp Met Glu Ala Ala His Met Ala Ala Thr Ala Ile Leu Asn
                 725                 730                 735

 ctg tcc acg cgc tgc cgc gag atg ccg cag aac ctg agc acc aag ccg     2256
 Leu Ser Thr Arg Cys Arg Glu Met Pro Gln Asn Leu Ser Thr Lys Pro
             740                 745                 750

 cag gac ctg tgc gcc acg cgg aac cct gac atg gag gtg gat gag aac     2304
 Gln Asp Leu Cys Ala Thr Arg Asn Pro Asp Met Glu Val Asp Glu Asn
         755                 760                 765

 ggg acc ctg gac ctc agc atg aac aag cag agg ccg cgg gac agc tgc     2352
 Gly Thr Leu Asp Leu Ser Met Asn Lys Gln Arg Pro Arg Asp Ser Cys
     770                 775                 780

 tgc ccc atc ctg acc cct ctg gag ccc atg tcc ccc cag caa cag gca     2400
 Cys Pro Ile Leu Thr Pro Leu Glu Pro Met Ser Pro Gln Gln Gln Ala
 785                 790                 795                 800

 gtg atg aac aac cgg tgt ttc cag ctg ggc gag ggc gac tgc tgg gac     2448
 Val Met Asn Asn Arg Cys Phe Gln Leu Gly Glu Gly Asp Cys Trp Asp
                 805                 810                 815

 ttg ccc gta gac tac acc aaa atg aaa ccc cgg agg ata gac gag gac     2496
 Leu Pro Val Asp Tyr Thr Lys Met Lys Pro Arg Arg Ile Asp Glu Asp
             820                 825                 830

 gag tcc aaa gac att act cca gaa gac ttg gac cca ttc cag gag gct     2544
 Glu Ser Lys Asp Ile Thr Pro Glu Asp Leu Asp Pro Phe Gln Glu Ala
         835                 840                 845

 cta gaa gaa aga cgg tat ccc ggg gag gtg acc atc cca agt ccc aaa     2592
 Leu Glu Glu Arg Arg Tyr Pro Gly Glu Val Thr Ile Pro Ser Pro Lys
     850                 855                 860

 ccc aag tac cct cag tgc aag gag agc aaa aag gac tta ata act ctg     2640
 Pro Lys Tyr Pro Gln Cys Lys Glu Ser Lys Lys Asp Leu Ile Thr Leu
 865                 870                 875                 880

 tct ggc tgc ccc ctg gcg gac aaa agc att cga agt atg ctg gcc acc     2688
 Ser Gly Cys Pro Leu Ala Asp Lys Ser Ile Arg Ser Met Leu Ala Thr
                 885                 890                 895

 agc tcc caa gaa ctc aag tgc ccc acg cct ggc tgt gat ggt tct gga     2736
 Ser Ser Gln Glu Leu Lys Cys Pro Thr Pro Gly Cys Asp Gly Ser Gly
             900                 905                 910

 cat atc acc ggc aat tat gct tct cat cgg agc ctt tca ggt tgc cca     2784
 His Ile Thr Gly Asn Tyr Ala Ser His Arg Ser Leu Ser Gly Cys Pro
         915                 920                 925

 aga gca aag aaa agt ggt atc agg ata gca cag agc aaa gaa gat aaa     2832
 Arg Ala Lys Lys Ser Gly Ile Arg Ile Ala Gln Ser Lys Glu Asp Lys
     930                 935                 940

 gaa gat caa gaa ccc atc agg tgt ccg gtc ccc ggg tgc gac ggc cag     2880
 Glu Asp Gln Glu Pro Ile Arg Cys Pro Val Pro Gly Cys Asp Gly Gln
 945                 950                 955                 960

 ggc cac atc act ggg aag tac gcg tcc cat cgc agc gcc tcc ggg tgc     2928
 Gly His Ile Thr Gly Lys Tyr Ala Ser His Arg Ser Ala Ser Gly Cys
                 965                 970                 975

 ccc ttg gcg gcc aag agg cag aaa gac ggg tac ctg aat ggc tcc cag     2976
 Pro Leu Ala Ala Lys Arg Gln Lys Asp Gly Tyr Leu Asn Gly Ser Gln
             980                 985                 990

 ttc tcc tgg aag tcg gtc aag acg gaa ggc atg tcc tgc ccc acg cca     3024
 Phe Ser Trp Lys Ser Val Lys Thr Glu Gly Met Ser Cys Pro Thr Pro
         995                1000                1005

 ggg tgc gac ggc tca ggc cac gtc agc ggc agc ttc ctc aca cac cgc     3072
 Gly Cys Asp Gly Ser Gly His Val Ser Gly Ser Phe Leu Thr His Arg
    1010                1015                1020

 agc ttg tca gga tgc ccg aga gcc acg tca gcg atg aag aag gca aag     3120
 Ser Leu Ser Gly Cys Pro Arg Ala Thr Ser Ala Met Lys Lys Ala Lys
1025                1030                1035                1040

 ctt tct gga gag cag atg ctg acc atc aaa cag cgg gcc agc aac ggt     3168
 Leu Ser Gly Glu Gln Met Leu Thr Ile Lys Gln Arg Ala Ser Asn Gly
                1045                1050                1055

 ata gaa aat gat gaa gaa atc aaa cag tta gat gaa gaa atc aag gag     3216
 Ile Glu Asn Asp Glu Glu Ile Lys Gln Leu Asp Glu Glu Ile Lys Glu
            1060                1065                1070

 cta aat gaa tcc aat tcc cag atg gaa gcc gat atg att aaa ctc aga     3264
 Leu Asn Glu Ser Asn Ser Gln Met Glu Ala Asp Met Ile Lys Leu Arg
        1075                1080                1085

 act cag att acc acg atg gag agc aac ctg aag acc atc gaa gag gag     3312
 Thr Gln Ile Thr Thr Met Glu Ser Asn Leu Lys Thr Ile Glu Glu Glu
    1090                1095                1100

 aac aaa gtg att gag cag cag aac gag tct ctc ctc cac gag ctg gcg     3360
 Asn Lys Val Ile Glu Gln Gln Asn Glu Ser Leu Leu His Glu Leu Ala
1105                1110                1115                1120

 aac ctg agc cag tct ctg atc cac agc ctg gct aac atc cag ctg ccg     3408
 Asn Leu Ser Gln Ser Leu Ile His Ser Leu Ala Asn Ile Gln Leu Pro
                1125                1130                1135

 cac atg gat cca atc aat gaa caa aat ttt gat gct tac gtg act act     3456
 His Met Asp Pro Ile Asn Glu Gln Asn Phe Asp Ala Tyr Val Thr Thr
            1140                1145                1150

 ttg acg gaa atg tat aca aat caa gat cgt tat cag agt cca gaa aat     3504
 Leu Thr Glu Met Tyr Thr Asn Gln Asp Arg Tyr Gln Ser Pro Glu Asn
        1155                1160                1165

 aaa gcc cta ctg gaa aat ata aag cag gct gtg aga gga att caa ttc     3552
 Lys Ala Leu Leu Glu Asn Ile Lys Gln Ala Val Arg Gly Ile Gln Phe
    1170                1175                1180

 agg tct gaa cag ctg ctg tagtga tgaaactctt gcttaaaaag gatgcctctt     3606
 Arg Ser Glu Gln Leu Leu 
1185                1190

 gttttttgct gctgtaactt accagaaagt gttctatatt tatttctgtt tgaatttgaa   3666

 acagtgttat gcttacaaga cttcataatg attttatgtc ttgctttaaa gatagtacct   3726

 gcagaatagt ttttgaatac acccacattt tgtacgtttc catgtaagct gacatagtgt   3786

 tctgccatgt aatgtttata gctgctgatg tatgcacatt tgggggtata tctatttctg   3846

 aagaggtaag ctgatcaaaa taaatagagt gtaaattctt tttaatgctt tagtgattaa   3906

 atgttttagt attttgaact gaaatggaca cacaaacaca cacacgcaca cacagaccca   3966

 cagctttgaa tgatcatgtt gtggctgagc agccgctttt tagacgttat cattttgcct   4026

 catgttggag gactttatgg aatttaagaa atacattttg tgtgcatatt gtttcatagc   4086

 aagaattcgt tgcaaaaatg ctttattttt gaacaatgct tggaaatatt atgtgacttt   4146

 tttgtttgtt tgttttagga ggatggtgta tggtgggggc aataaatgag gttttttgca   4206

 ttccaaggaa atggcatatg gattaactgt aagaaatgaa ataagtaatt tattgtaaga   4266

 caacatcaag ccatggaaac ttggcagaag attcaaagca gcttaaacag cacttttaaa   4326

 ttaactccta agcgttacat ggttgtgact atggaaactc cagttaagac aggatcttat   4386

 cagaggtgga caacgtgaag atttcctttt ccattttcaa taaactttgg aacaaccttc   4446

 tcgtatctcc cctagagttt cgtgcccctc tgaactgtct gttattgcaa tgtagtttat   4506

 caacagaatt tgtgtgtttt cgatttaagc taaaagataa tttaagaaca tttatttccc   4566

 cttttcactt taaaaaatta tgattattcc tattattgtt atgaaccttc ttattttaca   4626

 tttgagggat aaaggcaaat gatttgtgag tcttctagtt actggaccga gttttctgct   4686

 ggatctggtg ggaaggcagc tcggtaaagt ttccctcctg ctccccccgc ccgactttga   4746

 ctctgaatca gcatttggtc ctattcagag gactcttacc acgacgtttc tgttctacac   4806

 ttgggtggag accagttgac catagagcat ttgcagagcc tcattgtttg atttcttgtg   4866

 actattctaa gaatgaatgc aatcagattt taaaagtaac taaatatact tcagcacttt   4926

 tttgctttaa actagatcat cttagacttg tttatacctt ccagatttga ttgttttact   4986

 cccaatgact gcactatatg tatgcataag accacttttg agcgctgtgt tcccccttct   5046

 gagtagtcct ttgacgacgt gttgtgtttt ctgatgttga cttgagttcc atttagtagc   5106

 atctcttcct tccatgtctt gatgttatgc aggaagtaca gacgtacttt aaatttttgt   5166

 tatgaaataa aaaaaagatg ggttttgtaa aaataaaaaa aaaatatttt tagcagaaca   5226

 ggacttacag ggtcattgtc cccacaatgt gccagtcgac tatttgcact taccttgtcc   5286

 tatatatccg tacggaggtg tgcaattcct cgtgtcagta gccttgtgac actgaacctg   5346

 gatggattat agaggagccc tcacggctga tcaataatgt tgcaaaggga gactacaggg   5406

 atctcacgac gaatattctg atacaatact caacctcggt atatatatat gtgtataaat   5466

 atatgtatat cccagcggca ctttatactg ttcactgtac aaaagcttac agttttccac   5526

 aaggacttta ataactagct gggaaaagac gatgtaatta tttcggggct ctgcggaacc   5586

 ttctctgtac agcgccccct ttctgttgtg ctattggttg cagctgccat gctcagaatg   5646

 cgttttgaga gctgaagcaa ggtgcttgca gtcacctgag gccgtccgtg tggcccaggg   5706

 ccccagctgc ctttagggcc cccattgttc ataacagcat atgcatttcc ccaccgcgtt   5766

 gtgtctgcag cttctttgcc aatatagtaa tgcttttagt agagtactag atagtatcag   5826

 ttttggattc ttattgttat cacctatgta caatggaaag ggattttaag cacaaacctg   5886

 ctgctcatct aacgttggta cataatctca aatcaaaagt tatctgtgac tattatatag   5946

 ggatcacaaa agtgtcacat attagaatgc tgacctttca tatggattat tgtgagtcat   6006

 cagagtttat tataacttat tgttcatatt catttctaag ttaatttaag taatcattta   6066

 ttaagacaga attttgtata aactatttat tgtgctctct gtggaactga agtttgattt   6126

 atttttgtac tacacggcat gggtttgttg acactttaat tttgctataa atgtgtggaa   6186

 tcacaagttg ctgtgatact tcatttttaa attgtgaact ttgtacaaat tttgtcatgc   6246

 tggatgttaa cacatcttac tctaaataaa caaggtgttg ccacatttgt agcacgaagg   6306

 atctctaaaa aaaaaaaa                                                 6324




      <210> 55
      <211> 3062
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2136)

      <400> 55
  atg gag ggc agt ggg acc gga aaa aga cgt gga aaa gct gcg aaa acg      48
  Met Glu Gly Ser Gly Thr Gly Lys Arg Arg Gly Lys Ala Ala Lys Thr
    1               5                  10                  15

 agc ctt cga atc atg gac gcg cgg gcc cag ctc ctc ctc cga gtt cct       96
 Ser Leu Arg Ile Met Asp Ala Arg Ala Gln Leu Leu Leu Arg Val Pro
              20                  25                  30

 cat ccg ggg ccg tca ctc aca tcc ggg gcc ctc act cac atc cgg gac      144
 His Pro Gly Pro Ser Leu Thr Ser Gly Ala Leu Thr His Ile Arg Asp
          35                  40                  45

 cct cat ccg ggg ctc tca ccc aca tcc ggg acc ctc atg cct ggg cgg      192
 Pro His Pro Gly Leu Ser Pro Thr Ser Gly Thr Leu Met Pro Gly Arg
      50                  55                  60

 agg agg ggg ggc cct cat tcg gga ccc tgc act ccg tcg ccg gaa gtg      240
 Arg Arg Gly Gly Pro His Ser Gly Pro Cys Thr Pro Ser Pro Glu Val
  65                  70                  75                  80

 cca ccg aga agc gcc ggc ctc ggg gct gtc tac agc ggc ccg gga gag      288
 Pro Pro Arg Ser Ala Gly Leu Gly Ala Val Tyr Ser Gly Pro Gly Glu
                  85                  90                  95

 gct gtg gtg gcc ccg agc gcg agt gta gca gtg atg gag gaa ata cca      336
 Ala Val Val Ala Pro Ser Ala Ser Val Ala Val Met Glu Glu Ile Pro
             100                 105                 110

 gcc cag gaa gca gca ggg tca cca agg gtc cag ttt cag tct ttg gag      384
 Ala Gln Glu Ala Ala Gly Ser Pro Arg Val Gln Phe Gln Ser Leu Glu
         115                 120                 125

 acc cag tct gag tgt ctg tcc cca gag cct cag ttt gtg cag gac acc      432
 Thr Gln Ser Glu Cys Leu Ser Pro Glu Pro Gln Phe Val Gln Asp Thr
     130                 135                 140

 gac atg gaa cgt ggt ctc act ggg gct cca cct gtt cct cag gtg cct      480
 Asp Met Glu Arg Gly Leu Thr Gly Ala Pro Pro Val Pro Gln Val Pro
 145                 150                 155                 160

 gct ctt ccc cgt gag gga agc cca gga gac cag gca gct gcg ctc ttg      528
 Ala Leu Pro Arg Glu Gly Ser Pro Gly Asp Gln Ala Ala Ala Leu Leu
                 165                 170                 175

 aca gcc agg tac cag agc agc cag gat gtg tta ttt cag gag ttt gtg      576
 Thr Ala Arg Tyr Gln Ser Ser Gln Asp Val Leu Phe Gln Glu Phe Val
             180                 185                 190

 aca ttc gag gat gtg gct gtg cac ctt act cga gag gaa tgg gga tac      624
 Thr Phe Glu Asp Val Ala Val His Leu Thr Arg Glu Glu Trp Gly Tyr
         195                 200                 205

 ctg gac cct gtt cag agg gac ctc tac aga gaa gtg atg tta gag aat      672
 Leu Asp Pro Val Gln Arg Asp Leu Tyr Arg Glu Val Met Leu Glu Asn
     210                 215                 220

 tat ggg aac gtg gtc tca ctg gga ttt cca att tcc aag cct gat ggg      720
 Tyr Gly Asn Val Val Ser Leu Gly Phe Pro Ile Ser Lys Pro Asp Gly
 225                 230                 235                 240

 atc tcc cag ctg gaa cag gat cta cag gtc ttt gat ctg gaa act aag      768
 Ile Ser Gln Leu Glu Gln Asp Leu Gln Val Phe Asp Leu Glu Thr Lys
                 245                 250                 255

 act aga gaa gtc tta aga gat gac tgc tca gat gga gag acc aga gaa      816
 Thr Arg Glu Val Leu Arg Asp Asp Cys Ser Asp Gly Glu Thr Arg Glu
             260                 265                 270

 gag aac aag ctg ttg att cct aag cag aaa att tcg gaa gaa gtg cat      864
 Glu Asn Lys Leu Leu Ile Pro Lys Gln Lys Ile Ser Glu Glu Val His
         275                 280                 285

 tca tac aaa gtg aga gta gga aga ctc aaa cac gat att acc caa gtt      912
 Ser Tyr Lys Val Arg Val Gly Arg Leu Lys His Asp Ile Thr Gln Val
     290                 295                 300

 cct gag act aga gaa gtg tat aag tct gag gac aga tta gaa aga ctt      960
 Pro Glu Thr Arg Glu Val Tyr Lys Ser Glu Asp Arg Leu Glu Arg Leu
 305                 310                 315                 320

 cag gaa att cta agg aaa ttt ctg tac ctg gag aga gag ttt agg caa     1008
 Gln Glu Ile Leu Arg Lys Phe Leu Tyr Leu Glu Arg Glu Phe Arg Gln
                 325                 330                 335

 ata aca atc agc aag gaa acc ttc acc agt gag aag aac aat gaa tgt     1056
 Ile Thr Ile Ser Lys Glu Thr Phe Thr Ser Glu Lys Asn Asn Glu Cys
             340                 345                 350

 cat gaa ccc gaa aaa agc ttc agt ctg gac tct act att gat gca gat     1104
 His Glu Pro Glu Lys Ser Phe Ser Leu Asp Ser Thr Ile Asp Ala Asp
         355                 360                 365

 cag aga gtt ctt aga ata cag aat acc gat gac aat gat aag tat gac     1152
 Gln Arg Val Leu Arg Ile Gln Asn Thr Asp Asp Asn Asp Lys Tyr Asp
     370                 375                 380

 atg agc ttc aac cag aat tca gcc tct ggt aaa cat gaa cac tta aat     1200
 Met Ser Phe Asn Gln Asn Ser Ala Ser Gly Lys His Glu His Leu Asn
 385                 390                 395                 400

 cta aca gag gat ttt cag agt agt gaa tgt aag gaa agc tta atg gat     1248
 Leu Thr Glu Asp Phe Gln Ser Ser Glu Cys Lys Glu Ser Leu Met Asp
                 405                 410                 415

 ctc tcc cac ctt aat aaa tgg gag agc atc cct aac act gag aaa tcc     1296
 Leu Ser His Leu Asn Lys Trp Glu Ser Ile Pro Asn Thr Glu Lys Ser
             420                 425                 430

 tat aaa tgt gat gta tgt ggg aaa att ttc cat cag agc tca gcc ctt     1344
 Tyr Lys Cys Asp Val Cys Gly Lys Ile Phe His Gln Ser Ser Ala Leu
         435                 440                 445

 act aga cat cag aga atc cat act aga gag aag ccc tac aaa tgt aaa     1392
 Thr Arg His Gln Arg Ile His Thr Arg Glu Lys Pro Tyr Lys Cys Lys
     450                 455                 460

 gaa tgt gaa aag tct ttc agt cag agc tca agt ctt agt cga cat aaa     1440
 Glu Cys Glu Lys Ser Phe Ser Gln Ser Ser Ser Leu Ser Arg His Lys
 465                 470                 475                 480

 aga ata cac act aga gaa aaa cct tac aaa tgt gaa gca tct gat aaa     1488
 Arg Ile His Thr Arg Glu Lys Pro Tyr Lys Cys Glu Ala Ser Asp Lys
                 485                 490                 495

 tcc tgt gaa gcg tct gat aaa tcc tgt agt cca agc tca ggc ata att     1536
 Ser Cys Glu Ala Ser Asp Lys Ser Cys Ser Pro Ser Ser Gly Ile Ile
             500                 505                 510

 cag cat aag aaa att cac acc aga gcc aaa tct tac aaa tgt agc agt     1584
 Gln His Lys Lys Ile His Thr Arg Ala Lys Ser Tyr Lys Cys Ser Ser
         515                 520                 525

 tgt gaa aga gtc ttc agt cgt agt gtc cac ctt act caa cat cag aaa     1632
 Cys Glu Arg Val Phe Ser Arg Ser Val His Leu Thr Gln His Gln Lys
     530                 535                 540

 att cac aaa gag atg ccc tgt aag tgt act gta tgt ggc agt gac ttc     1680
 Ile His Lys Glu Met Pro Cys Lys Cys Thr Val Cys Gly Ser Asp Phe
 545                 550                 555                 560

 tgc cat act tca tac cta ctt gaa cat cag agg gtc cat cat gaa gag     1728
 Cys His Thr Ser Tyr Leu Leu Glu His Gln Arg Val His His Glu Glu
                 565                 570                 575

 aaa gcc tat gag tat gat gaa tat ggg ttg gcc tat att aaa caa caa     1776
 Lys Ala Tyr Glu Tyr Asp Glu Tyr Gly Leu Ala Tyr Ile Lys Gln Gln
             580                 585                 590

 gga att cat ttc aga gaa aag ccc tat acg tgt agt gaa tgt gga aaa     1824
 Gly Ile His Phe Arg Glu Lys Pro Tyr Thr Cys Ser Glu Cys Gly Lys
         595                 600                 605

 gac ttc aga ttg aat tca cat ctt att cag cat caa aga att cac aca     1872
 Asp Phe Arg Leu Asn Ser His Leu Ile Gln His Gln Arg Ile His Thr
     610                 615                 620

 gga gag aaa gca cat gaa tgt aat gaa tgt gga aaa gct ttc agt caa     1920
 Gly Glu Lys Ala His Glu Cys Asn Glu Cys Gly Lys Ala Phe Ser Gln
 625                 630                 635                 640

 acc tca tgc ctt att cag cat cac aaa atg cat agg aaa gag aaa tcg     1968
 Thr Ser Cys Leu Ile Gln His His Lys Met His Arg Lys Glu Lys Ser
                 645                 650                 655

 tat gaa tgt aat gag tat gag ggc agt ttc agt cat agc tca gat ctt     2016
 Tyr Glu Cys Asn Glu Tyr Glu Gly Ser Phe Ser His Ser Ser Asp Leu
             660                 665                 670

 atc ctg caa caa gaa gtc ctc acc aga cag aaa gcc ttt gat tgt gat     2064
 Ile Leu Gln Gln Glu Val Leu Thr Arg Gln Lys Ala Phe Asp Cys Asp
         675                 680                 685

 gta tgg gaa aag aac tcc agt cag aga gca cat cta gtt caa cat cag     2112
 Val Trp Glu Lys Asn Ser Ser Gln Arg Ala His Leu Val Gln His Gln
     690                 695                 700

 agc att cat acc aaa gag aac tca tgaatgtaat gaagatggga agatatttat    2166
 Ser Ile His Thr Lys Glu Asn Ser 
 705                 710

 caaattcagg cttcattcag catctgagag ttcacaccag ggagaaatca tgtatgtact   2226

 gcatgtggta aagccttcag tcatagctca gccattgctc agcatcagat aattcacacc   2286

 agagagaaac cctctgaatg tgacgaatga agaaaaggta ttagtgttaa actcttaatc   2346

 gactcctgca aatctatacc agtgagaaat cttacaaatg tattgaatgt ggcaaatttt   2406

 tcatgctatt agtattttca taccttagtc acatttggag aattcacatg ggaataaaat   2466

 tccattgctg caatgaatgt gaaaaagcca tcagtcaaag aaactacctt gtttagtatc   2526

 aaattcacgc catgcaaaaa gattataaat gtaataagca tgtatgtgtg tgaggagatt   2586

 cagtcataac ccaacgctca ttcaacatca aagaatttat acctaagaga acttatttgg   2646

 gtgtagtaaa tggcagatct ttcaatagga gtttaactag tctttgtcat atcagaatat   2706

 ccatagtaga caagaatttg atgtaacgca aatggaaaaa ctcgacacca catttcaggc   2766

 tttacccaac atcgaaataa tggagagaaa attgttgatt atttgtttat gaaattgtta   2826

 atacatagtc ccaatctttt tcattgcaca aaaatctagg gttgacttgg taaatgcagt   2886

 gacattttct catggagttc ctttatttaa tatgtattct aagtaggtac gtttattttt   2946

 acttttttat tataattttg atattaaaaa gaacagagat ggggtcttgc tttgttgccc   3006

 aggctggtct tgaactcctg gcctcaagcg atcctcccac ctgtcctccc aaagtg       3062




      <210> 56
      <211> 719
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (378)..(680)

      <400> 56
 aattcgcggc cgcgtcgacc acgaggcgat ttgtgggcca taccaaggat gtgctgagtg     60

 tggccttctc ctctgacaac cggcagattg tctctggatc tcgagataaa accatcaagc    120

 tatggaatac cctgggtgtg tgcaaataca ctgtccagga tgagagccac tcagagtggg    180

 tgtcttgtgt ccgcttctcg cccaacagca gcaaccctat catcgtctcc tgtggctggg    240

 acaagctggt caaggtatgg aacctggcta actgcaagct gaagaccaac cacattggcc    300

 acacaggcta tctgaacacg gtgactgtct ctccagatgg atccctctgt gcttctggag    360

 gcaaggatgg ccaggcc   atg tta tgg gat ctc aac gaa ggc aaa cac ctt     410
                      Met Leu Trp Asp Leu Asn Glu Gly Lys His Leu
                        1               5                  10

 tac acg cta gat ggt ggg gac atc atc aac gcc ctg tgc ttc agc cct      458
 Tyr Thr Leu Asp Gly Gly Asp Ile Ile Asn Ala Leu Cys Phe Ser Pro
              15                  20                  25

 aac cgc tac tgg ctg tgt gct gcc aca ggc ccc agc atc aag atc tgg      506
 Asn Arg Tyr Trp Leu Cys Ala Ala Thr Gly Pro Ser Ile Lys Ile Trp
          30                  35                  40

 gat tta gag gga aag atc att gta gat gaa ctg aag caa gaa gtt atc      554
 Asp Leu Glu Gly Lys Ile Ile Val Asp Glu Leu Lys Gln Glu Val Ile
      45                  50                  55

 agt acc agc agc aag gca gaa cca ccc cag tgc acc tcc ctg gcc tgg      602
 Ser Thr Ser Ser Lys Ala Glu Pro Pro Gln Cys Thr Ser Leu Ala Trp
  60                  65                  70                  75

 tct gct gat ggc cag act ctg ttt gct ggc tac acg gac aac ctg gtg      650
 Ser Ala Asp Gly Gln Thr Leu Phe Ala Gly Tyr Thr Asp Asn Leu Val
                  80                  85                  90

 cga gtg tgg cag gtg acc att ggc aca cgc t agaagtttat ggcagagctt      701
 Arg Val Trp Gln Val Thr Ile Gly Thr Arg 
              95                 100

 tacaaataaa aaaaaaaa                                                  719




      <210> 57
      <211> 1730
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (234)..(1355)

      <400> 57
 gcacgagccc ggctggtgtg tgtcggtgtg tatgtgtgtg tgtgagtgtg cgcgctccga     60

 gtgtgtgtgt atttgtgtat cggcggtccc gcaggtcccg gatgttgcgg acagtatgag    120

 gcaagcgcag ggggacgggg accagcagct gtcgccgccg ctctcagggt gaagagggaa    180

 cagaaatctt tgccccctga ctttggaaat ctcgtttaac cttcaaactg gcg   atg     236
                                                              Met
                                                                1

 tca agg gtt cca agt cct cca cct ccg gca gaa atg tcg agt ggc ccc      284
 Ser Arg Val Pro Ser Pro Pro Pro Pro Ala Glu Met Ser Ser Gly Pro
               5                  10                  15

 gta gct gag agt tgg tgc tac aca cag atc aag gta gtg aaa ttc tcc      332
 Val Ala Glu Ser Trp Cys Tyr Thr Gln Ile Lys Val Val Lys Phe Ser
          20                  25                  30

 tac atg tgg acc atc aat aac ttt agc ttt tgc cgg gag gaa atg ggt      380
 Tyr Met Trp Thr Ile Asn Asn Phe Ser Phe Cys Arg Glu Glu Met Gly
      35                  40                  45

 gaa gtc att aaa agt tct aca ttt tca tca gga gca aat gat aaa ctg      428
 Glu Val Ile Lys Ser Ser Thr Phe Ser Ser Gly Ala Asn Asp Lys Leu
  50                  55                  60                  65

 aaa tgg tgt ttg cga gta aac ccc aaa ggg tta gat gaa gaa agc aaa      476
 Lys Trp Cys Leu Arg Val Asn Pro Lys Gly Leu Asp Glu Glu Ser Lys
                  70                  75                  80

 gat tac ctg tca ctt tac ctg tta ctg gtc agc tgt cca aag agt gaa      524
 Asp Tyr Leu Ser Leu Tyr Leu Leu Leu Val Ser Cys Pro Lys Ser Glu
              85                  90                  95

 gtt cgg gca aaa ttc aaa ttc tcc atc ctg aat gcc aag gga gaa gaa      572
 Val Arg Ala Lys Phe Lys Phe Ser Ile Leu Asn Ala Lys Gly Glu Glu
         100                 105                 110

 acc aaa gct atg gag agt caa cgg gca tat agg ttt gtg caa ggc aaa      620
 Thr Lys Ala Met Glu Ser Gln Arg Ala Tyr Arg Phe Val Gln Gly Lys
     115                 120                 125

 gac tgg gga ttc aag aaa ttc atc cgt aga gat ttt ctt ttg gat gag      668
 Asp Trp Gly Phe Lys Lys Phe Ile Arg Arg Asp Phe Leu Leu Asp Glu
 130                 135                 140                 145

 gcc aac ggg ctt ctc cct gat gac aag ctt acc ctc ttc tgc gag gtg      716
 Ala Asn Gly Leu Leu Pro Asp Asp Lys Leu Thr Leu Phe Cys Glu Val
                 150                 155                 160

 agt gtt gtg caa gat tct gtc aac att tct ggc cag aat acc atg aac      764
 Ser Val Val Gln Asp Ser Val Asn Ile Ser Gly Gln Asn Thr Met Asn
             165                 170                 175

 atg gta aag gtt cct gag tgc cgg ctg gca gat gag tta gga gga ctg      812
 Met Val Lys Val Pro Glu Cys Arg Leu Ala Asp Glu Leu Gly Gly Leu
         180                 185                 190

 tgg gag aat tcc cgg ttc aca gac tgc tgc ttg tgt gtt gcc ggc cag      860
 Trp Glu Asn Ser Arg Phe Thr Asp Cys Cys Leu Cys Val Ala Gly Gln
     195                 200                 205

 gaa ttc cag gct cac aag gct atc tta gca gct cgt tct ccg gtt ttt      908
 Glu Phe Gln Ala His Lys Ala Ile Leu Ala Ala Arg Ser Pro Val Phe
 210                 215                 220                 225

 agt gcc atg ttt gaa cat gaa atg gag gag agc aaa aag aat cga gtt      956
 Ser Ala Met Phe Glu His Glu Met Glu Glu Ser Lys Lys Asn Arg Val
                 230                 235                 240

 gaa atc aat gat gtg gag cct gaa gtt ttt aag gaa atg atg tgc ttc     1004
 Glu Ile Asn Asp Val Glu Pro Glu Val Phe Lys Glu Met Met Cys Phe
             245                 250                 255

 att tac acg ggg aag gct cca aac ctc gac aaa atg gct gat gat ttg     1052
 Ile Tyr Thr Gly Lys Ala Pro Asn Leu Asp Lys Met Ala Asp Asp Leu
         260                 265                 270

 ctg gca gct gct gac aag tat gcc ctg gag cgc tta aag gtc atg tgt     1100
 Leu Ala Ala Ala Asp Lys Tyr Ala Leu Glu Arg Leu Lys Val Met Cys
     275                 280                 285

 gag gat gcc ctc tgc agt aac ctg tcc gtg gag aac gct gca gaa att     1148
 Glu Asp Ala Leu Cys Ser Asn Leu Ser Val Glu Asn Ala Ala Glu Ile
 290                 295                 300                 305

 ctc atc ctg gcc gac ctc cac agt gca gat cag ttg aaa act cag gca     1196
 Leu Ile Leu Ala Asp Leu His Ser Ala Asp Gln Leu Lys Thr Gln Ala
                 310                 315                 320

 gtg gat ttc atc aac tat cat gct tcg gat gtc ttg gag acc tct ggg     1244
 Val Asp Phe Ile Asn Tyr His Ala Ser Asp Val Leu Glu Thr Ser Gly
             325                 330                 335

 tgg aag tca atg gtg gtg tca cat ccc cac ttg gtg gct gag gca tac     1292
 Trp Lys Ser Met Val Val Ser His Pro His Leu Val Ala Glu Ala Tyr
         340                 345                 350

 cgc tct ctg gct tca gca cag tgc cct ttt ctg gga ccc cca cgc aaa     1340
 Arg Ser Leu Ala Ser Ala Gln Cys Pro Phe Leu Gly Pro Pro Arg Lys
     355                 360                 365

 cgc ctg aag caa tcc taagatcctg cttgttgtaa gactccgttt aatttccaga     1395
 Arg Leu Lys Gln Ser 
 370

 agcagcagcc actgttgctg ccactgacca ccaggtagac agcgcaatct gtggagcttt   1455

 tactctgttg tgaggggaag agactgcatt gtggccccag acttttaaaa cagcactaaa   1515

 taacttgggg gaaacggggg gagggaaaat gaaatgaaaa ccctgttgct gcgtcactgt   1575

 gttccctttg gcctggctga gtttgatact gtggggattc agtttaggcg ctggcccgag   1635

 gatatcccag cggtggtact tcggagacac ctgtctgcat ctgactgagc agaacaaatc   1695

 gtcaggtgcc tggagcaaaa aggaaaaaaa aaaaa                              1730




      <210> 58
      <211> 1743
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (142)..(1551)

      <400> 58
 gcggcggcga ggggaaaggg agcgcggggg ctgggtggaa tcgaggagtg aggaaaaagg     60

 gaaggggcgg gggagaggga ccagggaagg cgtcgggggg aatctcgcga gggttggagt    120

 tttggcgaga gtttgtggaa g  atg gcg cct gtt gtg aca ggg aaa ttt ggt     171
                          Met Ala Pro Val Val Thr Gly Lys Phe Gly
                            1               5                  10

 gag cgg cct cca cct aaa cga ctt act agg gaa gct atg cga aat tat      219
 Glu Arg Pro Pro Pro Lys Arg Leu Thr Arg Glu Ala Met Arg Asn Tyr
                  15                  20                  25

 tta aaa gag cga ggg gat caa aca gta ctt att ctt cat gca aaa gtt      267
 Leu Lys Glu Arg Gly Asp Gln Thr Val Leu Ile Leu His Ala Lys Val
              30                  35                  40

 gca cag aag tca tat gga aat gaa aaa agg ttt ttt tgc cca cct cct      315
 Ala Gln Lys Ser Tyr Gly Asn Glu Lys Arg Phe Phe Cys Pro Pro Pro
          45                  50                  55

 tgt gta tat ctt atg ggc agt gga tgg aag aaa aaa aaa gaa caa atg      363
 Cys Val Tyr Leu Met Gly Ser Gly Trp Lys Lys Lys Lys Glu Gln Met
      60                  65                  70

 gaa cgc gat ggt tgt tct gaa caa gag tct caa ccg tgt gca ttt att      411
 Glu Arg Asp Gly Cys Ser Glu Gln Glu Ser Gln Pro Cys Ala Phe Ile
  75                  80                  85                  90

 ggg ata gga aat agt gac caa gaa atg cag cag cta aac ttg gaa gga      459
 Gly Ile Gly Asn Ser Asp Gln Glu Met Gln Gln Leu Asn Leu Glu Gly
                  95                 100                 105

 aag aac tat tgc aca gcc aaa aca ttg tat ata tct gac tca gac aag      507
 Lys Asn Tyr Cys Thr Ala Lys Thr Leu Tyr Ile Ser Asp Ser Asp Lys
             110                 115                 120

 cga aag cac ttc atg ttg tct gta aag atg ttc tat ggc aac agt gat      555
 Arg Lys His Phe Met Leu Ser Val Lys Met Phe Tyr Gly Asn Ser Asp
         125                 130                 135

 gac att ggt gtg ttc ctc agc aag cgg ata aaa gtc atc tcc aaa cct      603
 Asp Ile Gly Val Phe Leu Ser Lys Arg Ile Lys Val Ile Ser Lys Pro
     140                 145                 150

 tcc aaa aag aag cag tca ttg aaa aat gct gac tta tgc att gcc tca      651
 Ser Lys Lys Lys Gln Ser Leu Lys Asn Ala Asp Leu Cys Ile Ala Ser
 155                 160                 165                 170

 gga aca aag gtg gct ctg ttt aat cga cta cga tcc cag aca gtt agt      699
 Gly Thr Lys Val Ala Leu Phe Asn Arg Leu Arg Ser Gln Thr Val Ser
                 175                 180                 185

 acc aga tac ttg cat gta gaa gga gtg gat gat gat gaa tca gaa gga      747
 Thr Arg Tyr Leu His Val Glu Gly Val Asp Asp Asp Glu Ser Glu Gly
             190                 195                 200

 gaa gaa ttc aca gtc cga gat ggc tac atc cat tat gga caa aca gtc      795
 Glu Glu Phe Thr Val Arg Asp Gly Tyr Ile His Tyr Gly Gln Thr Val
         205                 210                 215

 aaa ctt gtg tgc tca gtt act ggc atg gca ctc cca aga ttg ata att      843
 Lys Leu Val Cys Ser Val Thr Gly Met Ala Leu Pro Arg Leu Ile Ile
     220                 225                 230

 agg aaa gtt gat aag cag acc gca tta ttg gat gca gat gat cct gtg      891
 Arg Lys Val Asp Lys Gln Thr Ala Leu Leu Asp Ala Asp Asp Pro Val
 235                 240                 245                 250

 tca caa ctc cat aaa tgt gca ttt tac ctt aag gat aca gaa aga atg      939
 Ser Gln Leu His Lys Cys Ala Phe Tyr Leu Lys Asp Thr Glu Arg Met
                 255                 260                 265

 tat ttg tgc ctt tct caa gaa aga ata att caa ttt cag gcc act cca      987
 Tyr Leu Cys Leu Ser Gln Glu Arg Ile Ile Gln Phe Gln Ala Thr Pro
             270                 275                 280

 tgt cca aaa gaa cca aat aaa gag atg ata aat gat ggc gct tcc tgg     1035
 Cys Pro Lys Glu Pro Asn Lys Glu Met Ile Asn Asp Gly Ala Ser Trp
         285                 290                 295

 aca atc att agc aca gat aag gca gag tat aca ttt tat gag gga atg     1083
 Thr Ile Ile Ser Thr Asp Lys Ala Glu Tyr Thr Phe Tyr Glu Gly Met
     300                 305                 310

 ggc cct gtc ctt gcc cca gtc act cct gtg cct gtg gta gag agc ctt     1131
 Gly Pro Val Leu Ala Pro Val Thr Pro Val Pro Val Val Glu Ser Leu
 315                 320                 325                 330

 cag ttg aat ggc ggt ggg gac gta gca atg ctt gaa ctt aca gga cag     1179
 Gln Leu Asn Gly Gly Gly Asp Val Ala Met Leu Glu Leu Thr Gly Gln
                 335                 340                 345

 aat ttc act cca aat tta cga gtg tgg ttt ggg gat gta gaa gct gaa     1227
 Asn Phe Thr Pro Asn Leu Arg Val Trp Phe Gly Asp Val Glu Ala Glu
             350                 355                 360

 act atg tac agg tgt gga gag agt atg ctc tgt gtc gtc cca gac att     1275
 Thr Met Tyr Arg Cys Gly Glu Ser Met Leu Cys Val Val Pro Asp Ile
         365                 370                 375

 tct gca ttc cga gaa ggt tgg aga tgg gtc cgg caa cca gtc cag gtt     1323
 Ser Ala Phe Arg Glu Gly Trp Arg Trp Val Arg Gln Pro Val Gln Val
     380                 385                 390

 cca gta act ttg gtc cga aat gat gga atc att tat tcc acc agc ctt     1371
 Pro Val Thr Leu Val Arg Asn Asp Gly Ile Ile Tyr Ser Thr Ser Leu
 395                 400                 405                 410

 acc ttt acc tac aca cca gaa cca ggg ccg cgg cca cat tgc agt gca     1419
 Thr Phe Thr Tyr Thr Pro Glu Pro Gly Pro Arg Pro His Cys Ser Ala
                 415                 420                 425

 gca gga gca atc ctt cga gcc aat tca agc cag gtg ccc cct aac gaa     1467
 Ala Gly Ala Ile Leu Arg Ala Asn Ser Ser Gln Val Pro Pro Asn Glu
             430                 435                 440

 tca aac aca aac agc gag gga agt tac aca aac gcc agc aca aat tca     1515
 Ser Asn Thr Asn Ser Glu Gly Ser Tyr Thr Asn Ala Ser Thr Asn Ser
         445                 450                 455

 acc agt gtc aca tca tct aca gcc aca gtg gta tcc taac taccgtcttt     1565
 Thr Ser Val Thr Ser Ser Thr Ala Thr Val Val Ser 
     460                 465                 470

 ttgctaggac ttaaactgac ttgagtgtgg caaaaagtta acaaaaaagg agaaaaaatg   1625

 aacaatcgtt tgtggtttct tgggaaaact tttcatacca ggtgatacta ttcaaaaacc   1685

 ccgttgtctc cctgcaagtg ctgatttgaa atgcagaagc cacagtaaaa aaaaaaaa     1743




      <210> 59
      <211> 582
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (48)..(479)

      <400> 59
 ggtccggcgc ccagagctaa cgggagtccc aggttaaaca ctttaag  atg aga aaa      56
                                                      Met Arg Lys
                                                        1

 att gat ctc tgt ctg agc tct gaa ggg tcc gaa gtg att tta gct aca      104
 Ile Asp Leu Cys Leu Ser Ser Glu Gly Ser Glu Val Ile Leu Ala Thr
       5                  10                  15

 tca agt gat gaa aaa cac cca cct gaa aat atc att gat ggg aat cca      152
 Ser Ser Asp Glu Lys His Pro Pro Glu Asn Ile Ile Asp Gly Asn Pro
  20                  25                  30                  35

 gaa acg ttt tgg acc acc aca gga atg ttt ccc cag gaa ttc att att      200
 Glu Thr Phe Trp Thr Thr Thr Gly Met Phe Pro Gln Glu Phe Ile Ile
                  40                  45                  50

 tgt ttc cac aaa cat gta agg att gaa agg ctt gta atc caa agt tac      248
 Cys Phe His Lys His Val Arg Ile Glu Arg Leu Val Ile Gln Ser Tyr
              55                  60                  65

 ttt gta cag acc ttg aag att gaa aaa agc acg tct aaa gag cca gtt      296
 Phe Val Gln Thr Leu Lys Ile Glu Lys Ser Thr Ser Lys Glu Pro Val
          70                  75                  80

 gat ttt gag caa tgg att gaa aaa gat ttg gta cac aca gag ggg cag      344
 Asp Phe Glu Gln Trp Ile Glu Lys Asp Leu Val His Thr Glu Gly Gln
      85                  90                  95

 ctt caa aat gaa gaa att gtg gca cat gat ggc tcc gct act tac ttg      392
 Leu Gln Asn Glu Glu Ile Val Ala His Asp Gly Ser Ala Thr Tyr Leu
 100                 105                 110                 115

 aga ttc att att gta tca gcc ttt gat cat ttt gca tct gtg cat agc      440
 Arg Phe Ile Ile Val Ser Ala Phe Asp His Phe Ala Ser Val His Ser
                 120                 125                 130

 gtt tct gca gaa gga aca gta gtc tca aat ctt tcc tca taatgataac       489
 Val Ser Ala Glu Gly Thr Val Val Ser Asn Leu Ser Ser 
             135                 140

 aaaatgctct tgcatgattt tttaacaata tatttaaaca ggaagttgtc actgatatac    549

 tttattaaaa ggatttttat caaaaaaaaa aaa                                 582




      <210> 60
      <211> 518
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (53)..(415)

      <400> 60
 cggaaggtcc ggcgcccaga gctaacggga gtcccaggtt aaacacttta ag    atg      55
                                                              Met
                                                                1

 aga aaa att gat ctc tgt ctg agc tct gaa ggg tcc gaa gtg att tta      103
 Arg Lys Ile Asp Leu Cys Leu Ser Ser Glu Gly Ser Glu Val Ile Leu
               5                  10                  15

 gct aca tca agt gat gaa aaa cac cca cct gaa aat atc att gat ggg      151
 Ala Thr Ser Ser Asp Glu Lys His Pro Pro Glu Asn Ile Ile Asp Gly
          20                  25                  30

 aat cca gaa acg ttt tgg acc acc aca gga atg ttt ccc cag gaa ttc      199
 Asn Pro Glu Thr Phe Trp Thr Thr Thr Gly Met Phe Pro Gln Glu Phe
      35                  40                  45

 att att tgt ttc cac aaa cat gta agg att gaa agg ctt gta atc caa      247
 Ile Ile Cys Phe His Lys His Val Arg Ile Glu Arg Leu Val Ile Gln
  50                  55                  60                  65

 agt tac ttt gat ttg gta cac aca gag ggg cag ctt caa aat gaa gaa      295
 Ser Tyr Phe Asp Leu Val His Thr Glu Gly Gln Leu Gln Asn Glu Glu
                  70                  75                  80

 att gtg gca cat gat ggc tcc gct act tac ttg aga ttc att att gta      343
 Ile Val Ala His Asp Gly Ser Ala Thr Tyr Leu Arg Phe Ile Ile Val
              85                  90                  95

 tca gcc ttt gat cat ttt gca tct gtg cat agc gtt tct gca gaa gga      391
 Ser Ala Phe Asp His Phe Ala Ser Val His Ser Val Ser Ala Glu Gly
         100                 105                 110

 aca gta gtc tca aat ctt tcc tca taatgataac aaaatgctct tgcatgattt     445
 Thr Val Val Ser Asn Leu Ser Ser 
     115                 120

 tttaacaata tatttaaaca ggaagttgtc actgatatac tttattaaaa ggatttttat    505

 caaaaaaaaa aaa                                                       518




      <210> 61
      <211> 439
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (33)..(281)

      <400> 61
 gttgtggcgg ttgctggtca gtaacagcca ag  atg ctg cgg aat ctg ctg gct      53
                                      Met Leu Arg Asn Leu Leu Ala
                                        1               5

 ctt cgt cag att ggg cag agg acg ata agc act gct tcc cgc agg cat      101
 Leu Arg Gln Ile Gly Gln Arg Thr Ile Ser Thr Ala Ser Arg Arg His
          10                  15                  20

 ttt aaa aat aaa gtt ccg gag aag caa aaa ctg ttc cag gag gat gat      149
 Phe Lys Asn Lys Val Pro Glu Lys Gln Lys Leu Phe Gln Glu Asp Asp
      25                  30                  35

 gaa att cca ctg tat cta aag ggt ggg gta gct gat gcc ctc ctg tat      197
 Glu Ile Pro Leu Tyr Leu Lys Gly Gly Val Ala Asp Ala Leu Leu Tyr
  40                  45                  50                  55

 aga gcc acc atg att ctt aca gtt ggt gga aca gca tat gcc ata tat      245
 Arg Ala Thr Met Ile Leu Thr Val Gly Gly Thr Ala Tyr Ala Ile Tyr
                  60                  65                  70

 gag ctg gct gtg gct tca ttt ccc aag aag cag gag tgac ttcagtcatc      295
 Glu Leu Ala Val Ala Ser Phe Pro Lys Lys Gln Glu 
              75                  80

 ccagcaatcg cttggttcag tttcattcag ctctctatgg accagtaatc tgataaataa    355

 ccgagctctt ctttggggat caatatttat tgacttgtag taactgccac caataaagca    415

 gtctttacca tgaaaaaaaa aaaa                                           439




      <210> 62
      <211> 1233
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (353)..(823)

      <400> 62
 ggaattcccc taaaccacca gtgaacccca ctgctctcca gatgaggtcg caaggaccaa     60

 ccagtgccta cccgcccatg ctcccccgaa actgggaact gacagcccag cccctccaaa    120

 gccccttcct ccagcttcag ctgccaggtc agcaagggtg aggccggaag caggcgggtg    180

 actcaccctg ggcacctccg agcctcagtt tccccatgga tgcaacctga ggcctcctca    240

 ctgagtcaaa accgagacgc ctctggtccc cggagaggct gctggctctg gggaaaggag    300

 agagcagccc agtgtgacag agcgagtccc cacggctctg ggagtgcctc gc    atg     355
                                                              Met
                                                                1

 tgt gtg gcc cag gtc ctg aca gcc cac cta ctc cct ccc cgg cag gca      403
 Cys Val Ala Gln Val Leu Thr Ala His Leu Leu Pro Pro Arg Gln Ala
               5                  10                  15

 ctg ggc tcc ctc tgc tcc ccg tgg gcc gct ccc cgc gtg ggg cca ctg      451
 Leu Gly Ser Leu Cys Ser Pro Trp Ala Ala Pro Arg Val Gly Pro Leu
          20                  25                  30

 ccc ccg gcc ccc gcc atg gtg cgg att tca aag ccc aag acg ttt cag      499
 Pro Pro Ala Pro Ala Met Val Arg Ile Ser Lys Pro Lys Thr Phe Gln
      35                  40                  45

 gcc tac ttg gat gat tgt cac cgg agg tat agc tgt gcc cac tgc cgc      547
 Ala Tyr Leu Asp Asp Cys His Arg Arg Tyr Ser Cys Ala His Cys Arg
  50                  55                  60                  65

 gct cac ctg gcc aac cac gac gac ctc atc tcc aag tcc ttc cag ggc      595
 Ala His Leu Ala Asn His Asp Asp Leu Ile Ser Lys Ser Phe Gln Gly
                  70                  75                  80

 agt cag ggg cgt gcc tac ctc ttc aac tca gtg gtg aac gtg ggc tgc      643
 Ser Gln Gly Arg Ala Tyr Leu Phe Asn Ser Val Val Asn Val Gly Cys
              85                  90                  95

 ggg cca gcc gag gag cgg gtg ctg ctg acc ggc ctc cat gct gtc gcc      691
 Gly Pro Ala Glu Glu Arg Val Leu Leu Thr Gly Leu His Ala Val Ala
         100                 105                 110

 gac atc cac tgc gag aac tgc aag acc act ttg ggc tgg aaa tat gaa      739
 Asp Ile His Cys Glu Asn Cys Lys Thr Thr Leu Gly Trp Lys Tyr Glu
     115                 120                 125

 cag gcc ttt gag agc agc cag aag tac aaa gag ggg aag tac atc att      787
 Gln Ala Phe Glu Ser Ser Gln Lys Tyr Lys Glu Gly Lys Tyr Ile Ile
 130                 135                 140                 145

 gaa ctc aac cac atg atc aaa gac aac ggc tgg gac tgac ccccgctccc      837
 Glu Leu Asn His Met Ile Lys Asp Asn Gly Trp Asp 
                 150                 155

 ccgacgcatg tggctccagc ccggcctggc cgccagggag cgccactggc ttcccgccac    897

 ccgaagggag ctctggaccc tcagagcccc tgcagaggac ggatctagct cctgtatata    957

 tattttattg catgcactgt gaccttgggg ggagaacaga agggggacga cgcccccgca   1017

 cctcctgcga tctggctggc ttggatctcg tttttaaccc gttcctgccc cacctgccct   1077

 atagttatgg cctgtgttct gctctcctgg tcccagtgca ccgtctgctc tgtgaactcc   1137

 tcccaccagg cccttcttac cccacgcgtg tctgtccccc tcgttctgta gcgtttgtac   1197

 ataataaaac aatggagtgg agacaaaaaa aaaaaa                             1233




      <210> 63
      <211> 1076
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (11)..(856)

      <400> 63
 ggttgggaag   atg gcg agg cga ggc tgg gcg cag aca ggc tgg ggc tgc      49
              Met Ala Arg Arg Gly Trp Ala Gln Thr Gly Trp Gly Cys
                1               5                  10

 ggc caa gcg tgg ggt gcg tcg ggg ggc ggc cgc agc tgc gag gag ctc       97
 Gly Gln Ala Trp Gly Ala Ser Gly Gly Gly Arg Ser Cys Glu Glu Leu
      15                  20                  25

 act gcg gtc cta acc ccg ccg cag ctc ctc gga cgc agg ttt aac ttc      145
 Thr Ala Val Leu Thr Pro Pro Gln Leu Leu Gly Arg Arg Phe Asn Phe
  30                  35                  40                  45

 ttt att caa caa aaa tgc gga ttc aga aaa gca ccc agg aag gtt gaa      193
 Phe Ile Gln Gln Lys Cys Gly Phe Arg Lys Ala Pro Arg Lys Val Glu
                  50                  55                  60

 cct cga aga tca gac cca ggg aca agt ggt gaa gca tac aag aga agt      241
 Pro Arg Arg Ser Asp Pro Gly Thr Ser Gly Glu Ala Tyr Lys Arg Ser
              65                  70                  75

 gct ttg att cct cct gtg gaa gaa aca gtc ttt tat cct tct ccc tat      289
 Ala Leu Ile Pro Pro Val Glu Glu Thr Val Phe Tyr Pro Ser Pro Tyr
          80                  85                  90

 cct ata agg agt ctc ata aaa cct tta ttt ttt act gtt ggg att aac      337
 Pro Ile Arg Ser Leu Ile Lys Pro Leu Phe Phe Thr Val Gly Ile Asn
      95                 100                 105

 aag tgg tgg aat aac cta agt gat ggc cag cgg act gtg aca ggt att      385
 Lys Trp Trp Asn Asn Leu Ser Asp Gly Gln Arg Thr Val Thr Gly Ile
 110                 115                 120                 125

 ata gct gca aat gtc ctt gta ttc tgt tta tgg aga gta cct tct ctg      433
 Ile Ala Ala Asn Val Leu Val Phe Cys Leu Trp Arg Val Pro Ser Leu
                 130                 135                 140

 cag cgg aca atg atc aga tat ttc aca tcg aat cca gcc tca agt gtt      481
 Gln Arg Thr Met Ile Arg Tyr Phe Thr Ser Asn Pro Ala Ser Ser Val
             145                 150                 155

 att tcc aat ttt gtc agt tac gtg ggt aaa gtt gcc aca gga aga tat      529
 Ile Ser Asn Phe Val Ser Tyr Val Gly Lys Val Ala Thr Gly Arg Tyr
         160                 165                 170

 gga cca tca ctt ggt gca tct ggt gcc atc atg aca gtc ctc gca gct      577
 Gly Pro Ser Leu Gly Ala Ser Gly Ala Ile Met Thr Val Leu Ala Ala
     175                 180                 185

 gtc tgc act aag atc cca gaa ggg agg ctt gcc att att ttc ctt ccg      625
 Val Cys Thr Lys Ile Pro Glu Gly Arg Leu Ala Ile Ile Phe Leu Pro
 190                 195                 200                 205

 atg ttc acg ttc aca gca ggg aat gcc ctg aaa gcc att atc gcc atg      673
 Met Phe Thr Phe Thr Ala Gly Asn Ala Leu Lys Ala Ile Ile Ala Met
                 210                 215                 220

 gat aca gca gga atg atc ctg gga tgg aaa ttt ttt gat cat gcg gca      721
 Asp Thr Ala Gly Met Ile Leu Gly Trp Lys Phe Phe Asp His Ala Ala
             225                 230                 235

 cat ctt ggg gga gct ctt ttt gga ata tgg tat gtt act tac ggt cat      769
 His Leu Gly Gly Ala Leu Phe Gly Ile Trp Tyr Val Thr Tyr Gly His
         240                 245                 250

 gaa ctg att tgg aag aac agg gag ccg cta gtg aaa atc tgg cat gaa      817
 Glu Leu Ile Trp Lys Asn Arg Glu Pro Leu Val Lys Ile Trp His Glu
     255                 260                 265

 ata agg act aat ggc ccc aaa aaa gga ggt ggc tct aag taaaactggg       866
 Ile Arg Thr Asn Gly Pro Lys Lys Gly Gly Gly Ser Lys 
 270                 275                 280

 attggacagt agtggtgcat ctggtccttg ccgcctgaga gccccaggag acatcggcta    926

 gagtgaccat ggctatgctc ccgtctggaa gatgccagca tctggcctcc cactgttttc    986

 agctgtgtcc cccagtccgt gtctttttag aatgtgaatg atgataaagt tgtgaaataa   1046

 aggtttctat ctagtttgta aaaaaaaaaa                                    1076




      <210> 64
      <211> 1043
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (84)..(683)

      <400> 64
 tccccggccg gtcgacctcc tgcagcgtct ggggtttccg ttgcagtcct cggaaccagg     60

 acctcggcgt ggcctagcga gtt    atg gcg acg aag gcc gtg tgc gtg ctg     110
                              Met Ala Thr Lys Ala Val Cys Val Leu
                                1               5

 aag ggc gac ggc cca gtg cag ggc atc atc aat ttc gag cag aag gca      158
 Lys Gly Asp Gly Pro Val Gln Gly Ile Ile Asn Phe Glu Gln Lys Ala
  10                  15                  20                  25

 agg gct ggg acg gag gct tgt ttg cga ggc cgc tcc cac ccg ctc gtc      206
 Arg Ala Gly Thr Glu Ala Cys Leu Arg Gly Arg Ser His Pro Leu Val
                  30                  35                  40

 ccc ccg cgc acc ttt gtt agg agc ggg tcg ccc gcc agg cct cgg ggc      254
 Pro Pro Arg Thr Phe Val Arg Ser Gly Ser Pro Ala Arg Pro Arg Gly
              45                  50                  55

 cgc cct ggt cca gcg ccc ggt ccc ggc ccg tgc cgc ccg gaa agt aat      302
 Arg Pro Gly Pro Ala Pro Gly Pro Gly Pro Cys Arg Pro Glu Ser Asn
          60                  65                  70

 gga cca gtg aag gtg tgg gga agc att aaa gga ctg act gaa ggc ctg      350
 Gly Pro Val Lys Val Trp Gly Ser Ile Lys Gly Leu Thr Glu Gly Leu
      75                  80                  85

 cat gga ttc cat gtt cat gag ttt gga gat aat aca gca ggc tgt acc      398
 His Gly Phe His Val His Glu Phe Gly Asp Asn Thr Ala Gly Cys Thr
  90                  95                 100                 105

 agt gca ggt cct cac ttt aat cct cta tcc aga aaa cac ggt ggg cca      446
 Ser Ala Gly Pro His Phe Asn Pro Leu Ser Arg Lys His Gly Gly Pro
                 110                 115                 120

 aag gat gaa gag agg cat gtt gga gac ttg ggc aat gtg act gct gac      494
 Lys Asp Glu Glu Arg His Val Gly Asp Leu Gly Asn Val Thr Ala Asp
             125                 130                 135

 aaa gat ggt gtg gcc gat gtg tct att gaa gat tct gtg atc tca ctc      542
 Lys Asp Gly Val Ala Asp Val Ser Ile Glu Asp Ser Val Ile Ser Leu
         140                 145                 150

 tca gga gac cat tgc atc att ggc cgc aca ctg gtg gtc cat gaa aaa      590
 Ser Gly Asp His Cys Ile Ile Gly Arg Thr Leu Val Val His Glu Lys
     155                 160                 165

 gca gat gac ttg ggc aaa ggt gga aat gaa gaa agt aca aag aca gga      638
 Ala Asp Asp Leu Gly Lys Gly Gly Asn Glu Glu Ser Thr Lys Thr Gly
 170                 175                 180                 185

 aac gct gga agt cgt ttg gct tgt ggt gta att ggg atc gcc caa taa      686
 Asn Ala Gly Ser Arg Leu Ala Cys Gly Val Ile Gly Ile Ala Gln 
                 190                 195                 200

 acattccctt ggatgtagtc tgaggcccct taactcatct gttatcctgc tagctgtaga    746

 aatgtatcct gataaacatt aaacactgta atcttaaaag tgtaattgtg tgactttttc    806

 agagttgctt taaagtacct gtagtgagaa actgatttat gatcacttgg aagatttgta    866

 tagttttata aaactcagtt aaaatgtctg tttcaatgac ctgtattttg ccagacttaa    926

 atcacagatg ggtattaaac ttgtcagaat ttctttgtca ttcaagcctg tgaataaaaa    986

 ccctgtatgg cacttattat gaggctatta aaagaatcca aattcaaaaa aaaaaaa      1043




      <210> 65
      <211> 849
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (54)..(788)

      <400> 65
 gggtcgaccc acgcgtccga gtaggcagag agcggacctg gcggccgggc agc   atg      56
                                                              Met
                                                                1

 gcg ggg ctg gag ctc ttg tcg gac cag ggc tac cgg gtg gac ggg cgg      104
 Ala Gly Leu Glu Leu Leu Ser Asp Gln Gly Tyr Arg Val Asp Gly Arg
               5                  10                  15

 cgc gcc ggg gag ctg cgc aag atc cag gcg cgg atg ggc gtg ttc gcg      152
 Arg Ala Gly Glu Leu Arg Lys Ile Gln Ala Arg Met Gly Val Phe Ala
          20                  25                  30

 cag gct gac ggc tcg gcc tac att gag cag ggc aac acc aag gca ctg      200
 Gln Ala Asp Gly Ser Ala Tyr Ile Glu Gln Gly Asn Thr Lys Ala Leu
      35                  40                  45

 gct gtg gtc tac ggc ccg cac gag atc cgg ggc tcc cgg gct cga gcc      248
 Ala Val Val Tyr Gly Pro His Glu Ile Arg Gly Ser Arg Ala Arg Ala
  50                  55                  60                  65

 ctg ccg gac agg gcc cta gtg aac tgt caa tat agt tca gcg acc ttc      296
 Leu Pro Asp Arg Ala Leu Val Asn Cys Gln Tyr Ser Ser Ala Thr Phe
                  70                  75                  80

 agc aca ggt gag cgc aag cga cgg cca cat ggg gac cgt aag tcc tgt      344
 Ser Thr Gly Glu Arg Lys Arg Arg Pro His Gly Asp Arg Lys Ser Cys
              85                  90                  95

 gag atg ggc ctg cag ctc cgc cag act ttc gaa gca gcc atc ctc aca      392
 Glu Met Gly Leu Gln Leu Arg Gln Thr Phe Glu Ala Ala Ile Leu Thr
         100                 105                 110

 cag ctg cac cca cgc tcc cag att gat atc tat gtg cag gtg cta cag      440
 Gln Leu His Pro Arg Ser Gln Ile Asp Ile Tyr Val Gln Val Leu Gln
     115                 120                 125

 gca gat ggt ggg acc tat gca gct tgt gtg aat gca gcc acg ctg gca      488
 Ala Asp Gly Gly Thr Tyr Ala Ala Cys Val Asn Ala Ala Thr Leu Ala
 130                 135                 140                 145

 gtg ctg gat gcc ggg ata ccc atg aga gac ttt gtg tgt gcg tgc tca      536
 Val Leu Asp Ala Gly Ile Pro Met Arg Asp Phe Val Cys Ala Cys Ser
                 150                 155                 160

 gct ggc ttc gtg gac ggc aca gcc ctg gcg gac ctc agc cat gtg gag      584
 Ala Gly Phe Val Asp Gly Thr Ala Leu Ala Asp Leu Ser His Val Glu
             165                 170                 175

 gaa gca gct ggt ggc ccc cag ctg gcc ctg gcc ctg ctg cca gcc tca      632
 Glu Ala Ala Gly Gly Pro Gln Leu Ala Leu Ala Leu Leu Pro Ala Ser
         180                 185                 190

 gga cag att gcg ctg ctt gag atg gat gcc cgg ctg cac gag gac cac      680
 Gly Gln Ile Ala Leu Leu Glu Met Asp Ala Arg Leu His Glu Asp His
     195                 200                 205

 ctg gag cgg gtg ttg gag gct gct gcc cag gct gcc cga gat gtg cac      728
 Leu Glu Arg Val Leu Glu Ala Ala Ala Gln Ala Ala Arg Asp Val His
 210                 215                 220                 225

 acc ctc tta gat cga gtg gtc cgg cag cat gtg cgt gag gcc tct atc      776
 Thr Leu Leu Asp Arg Val Val Arg Gln His Val Arg Glu Ala Ser Ile
                 230                 235                 240

 ttg ctg ggg gac tga ccacccagcc acccatgtcc agaataaaac cctcctctgc      831
 Leu Leu Gly Asp 
             245

 ccacacaaaa aaaaaaaa                                                  849




      <210> 66
      <211> 3260
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (29)..(3226)

      <400> 66
 gccaaactcc gagtcgttcc tctggtgg   atg gcc tgc tgg cgt gcc gat gtc      52
                                  Met Ala Cys Trp Arg Ala Asp Val
                                    1               5

 tgt tgt gtg ctc ttc cgc cag cat tct ccc ttc aac gtc ctc tgg acg      100
 Cys Cys Val Leu Phe Arg Gln His Ser Pro Phe Asn Val Leu Trp Thr
      10                  15                  20

 tcc agc tgc ttg tat gtt ctt ccg ccg atg tgt tcc tct cga cgt cca      148
 Ser Ser Cys Leu Tyr Val Leu Pro Pro Met Cys Ser Ser Arg Arg Pro
  25                  30                  35                  40

 gcc gct ttg aat ttc ata aag gac aat agc cga gcc ctt att caa aga      196
 Ala Ala Leu Asn Phe Ile Lys Asp Asn Ser Arg Ala Leu Ile Gln Arg
                  45                  50                  55

 atg gga atg act att ata aag caa atc aca gat gac cta ttt gta tgg      244
 Met Gly Met Thr Ile Ile Lys Gln Ile Thr Asp Asp Leu Phe Val Trp
              60                  65                  70

 aat gtt ctg aat cgc gaa gaa gta aac atc att tgc tgc gag aag gtg      292
 Asn Val Leu Asn Arg Glu Glu Val Asn Ile Ile Cys Cys Glu Lys Val
          75                  80                  85

 gag cag gat gct gct agg ggg atc att cac atg att ttg aaa aag ggt      340
 Glu Gln Asp Ala Ala Arg Gly Ile Ile His Met Ile Leu Lys Lys Gly
      90                  95                 100

 tca gag tcc tgt aac ctc ttt ctt aaa tcc ctt aag gag tgg aac tat      388
 Ser Glu Ser Cys Asn Leu Phe Leu Lys Ser Leu Lys Glu Trp Asn Tyr
 105                 110                 115                 120

 cct cta ttt cag gac ttg aat gga caa agt ctt ttt cat cag aca tca      436
 Pro Leu Phe Gln Asp Leu Asn Gly Gln Ser Leu Phe His Gln Thr Ser
                 125                 130                 135

 gaa gga gac ttg gac gat ttg gct cag gat tta aag gac ttg tac cat      484
 Glu Gly Asp Leu Asp Asp Leu Ala Gln Asp Leu Lys Asp Leu Tyr His
             140                 145                 150

 acc cca tct ttt ctg aac ttt tat ccc ctt ggt gaa gat att gac att      532
 Thr Pro Ser Phe Leu Asn Phe Tyr Pro Leu Gly Glu Asp Ile Asp Ile
         155                 160                 165

 att ttt aac ttg aaa agc acc ttc aca gaa cct gtc ctg tgg agg aag      580
 Ile Phe Asn Leu Lys Ser Thr Phe Thr Glu Pro Val Leu Trp Arg Lys
     170                 175                 180

 gac caa cac cat cac cgc gtg gag cag ctg acc ctg aat ggc ctc ctg      628
 Asp Gln His His His Arg Val Glu Gln Leu Thr Leu Asn Gly Leu Leu
 185                 190                 195                 200

 cag gct ctt cag agc ccc tgc atc att gaa ggg gaa tct ggc aaa ggc      676
 Gln Ala Leu Gln Ser Pro Cys Ile Ile Glu Gly Glu Ser Gly Lys Gly
                 205                 210                 215

 aag tcc act ctg ctg cag cga att gcc atg ctc tgg ggc tcc gga aag      724
 Lys Ser Thr Leu Leu Gln Arg Ile Ala Met Leu Trp Gly Ser Gly Lys
             220                 225                 230

 tgc aag gct ctg acc aag ttc aaa ttc gtc ttc ttc ctc cgt ctc agc      772
 Cys Lys Ala Leu Thr Lys Phe Lys Phe Val Phe Phe Leu Arg Leu Ser
         235                 240                 245

 agg gcc cag ggt gga ctt ttt gaa acc ctc tgt gat caa ctc ctg gat      820
 Arg Ala Gln Gly Gly Leu Phe Glu Thr Leu Cys Asp Gln Leu Leu Asp
     250                 255                 260

 ata cct ggc aca atc agg aag cag aca ttc atg gcc atg ctg ctg aag      868
 Ile Pro Gly Thr Ile Arg Lys Gln Thr Phe Met Ala Met Leu Leu Lys
 265                 270                 275                 280

 ctg cgg cag agg gtt ctt ttc ctt ctt gat ggc tac aat gaa ttc aag      916
 Leu Arg Gln Arg Val Leu Phe Leu Leu Asp Gly Tyr Asn Glu Phe Lys
                 285                 290                 295

 ccc cag aac tgc cca gaa atc gaa gcc ctg ata aag gaa aac cac cgc      964
 Pro Gln Asn Cys Pro Glu Ile Glu Ala Leu Ile Lys Glu Asn His Arg
             300                 305                 310

 ttc aag aac atg gtc atc gtc acc act acc act gag tgc ctg agg cac     1012
 Phe Lys Asn Met Val Ile Val Thr Thr Thr Thr Glu Cys Leu Arg His
         315                 320                 325

 ata cgg cag ttt ggt gcc ctg act gct gag gtg ggg gat atg aca gaa     1060
 Ile Arg Gln Phe Gly Ala Leu Thr Ala Glu Val Gly Asp Met Thr Glu
     330                 335                 340

 gac agc gcc cag gct ctc atc cga gaa gtg ctg atc aag gag ctt gct     1108
 Asp Ser Ala Gln Ala Leu Ile Arg Glu Val Leu Ile Lys Glu Leu Ala
 345                 350                 355                 360

 gaa ggc ttg ttg ctc caa att cag aaa tcc agg tgc ttg agg aat ctc     1156
 Glu Gly Leu Leu Leu Gln Ile Gln Lys Ser Arg Cys Leu Arg Asn Leu
                 365                 370                 375

 atg aag acc cct ctc ttt gtg gtc atc act tgt gca atc cag atg ggt     1204
 Met Lys Thr Pro Leu Phe Val Val Ile Thr Cys Ala Ile Gln Met Gly
             380                 385                 390

 gaa agt gag ttc cac tct cac aca caa aca acg ctg ttc cat acc ttc     1252
 Glu Ser Glu Phe His Ser His Thr Gln Thr Thr Leu Phe His Thr Phe
         395                 400                 405

 tat gat ctg ttg ata cag aaa aac aaa cac aaa cat aaa ggt gtg gct     1300
 Tyr Asp Leu Leu Ile Gln Lys Asn Lys His Lys His Lys Gly Val Ala
     410                 415                 420

 gca agt gac ttc att cgg agc ctg gac cac tgt gga gac cta gct ctg     1348
 Ala Ser Asp Phe Ile Arg Ser Leu Asp His Cys Gly Asp Leu Ala Leu
 425                 430                 435                 440

 gag ggt gtg ttc tcc cac aag ttt gat ttc gaa ctg cag gat gtg tcc     1396
 Glu Gly Val Phe Ser His Lys Phe Asp Phe Glu Leu Gln Asp Val Ser
                 445                 450                 455

 agc gtg aat gag gat gtc ctg ctg aca act ggg ctc ctc tgt aaa tat     1444
 Ser Val Asn Glu Asp Val Leu Leu Thr Thr Gly Leu Leu Cys Lys Tyr
             460                 465                 470

 aca gct caa agg ttc aag cca aag tat aaa ttc ttt cac aag tca ttc     1492
 Thr Ala Gln Arg Phe Lys Pro Lys Tyr Lys Phe Phe His Lys Ser Phe
         475                 480                 485

 cag gag tac aca gca gga cga aga ctc agc agt tta ttg acg tct cat     1540
 Gln Glu Tyr Thr Ala Gly Arg Arg Leu Ser Ser Leu Leu Thr Ser His
     490                 495                 500

 gag cca gag gag gtg acc aag ggg aat ggt tac ttg cag aaa atg gtt     1588
 Glu Pro Glu Glu Val Thr Lys Gly Asn Gly Tyr Leu Gln Lys Met Val
 505                 510                 515                 520

 tcc att tcg gac att aca tcc act tat agc agc ctg ctc cgg tac acc     1636
 Ser Ile Ser Asp Ile Thr Ser Thr Tyr Ser Ser Leu Leu Arg Tyr Thr
                 525                 530                 535

 tgt ggg tca tct gtg gaa gcc acc agg gct gtt atg aag cac ctc gca     1684
 Cys Gly Ser Ser Val Glu Ala Thr Arg Ala Val Met Lys His Leu Ala
             540                 545                 550

 gca gtg tat caa cac ggc tgc ctt ctc gga ctt tcc atc gcc aag agg     1732
 Ala Val Tyr Gln His Gly Cys Leu Leu Gly Leu Ser Ile Ala Lys Arg
         555                 560                 565

 cct ctc tgg aga cag gaa tct ttg caa agt gtg aaa aac acc act gag     1780
 Pro Leu Trp Arg Gln Glu Ser Leu Gln Ser Val Lys Asn Thr Thr Glu
     570                 575                 580

 caa gaa att ctg aaa gcc ata aac atc aat tcc ttt gta gag tgt ggc     1828
 Gln Glu Ile Leu Lys Ala Ile Asn Ile Asn Ser Phe Val Glu Cys Gly
 585                 590                 595                 600

 atc cat tta tat caa gag agt aca tcc aaa tca gcc ctg agc caa gaa     1876
 Ile His Leu Tyr Gln Glu Ser Thr Ser Lys Ser Ala Leu Ser Gln Glu
                 605                 610                 615

 ttt gaa gct ttc ttt caa ggt aaa agc tta tat atc aac tca ggg aac     1924
 Phe Glu Ala Phe Phe Gln Gly Lys Ser Leu Tyr Ile Asn Ser Gly Asn
             620                 625                 630

 atc ccc gat tac tta ttt gac ttc ttt gaa cat ttg ccc aat tgt gca     1972
 Ile Pro Asp Tyr Leu Phe Asp Phe Phe Glu His Leu Pro Asn Cys Ala
         635                 640                 645

 agt gcc ctg gac ttc att aaa ctg ggc ttt tat ggg gga gct atg gct     2020
 Ser Ala Leu Asp Phe Ile Lys Leu Gly Phe Tyr Gly Gly Ala Met Ala
     650                 655                 660

 tca tgg gaa aag gct gca gaa gac aca ggt gga atc cac atg gaa gag     2068
 Ser Trp Glu Lys Ala Ala Glu Asp Thr Gly Gly Ile His Met Glu Glu
 665                 670                 675                 680

 gcc cca gaa acc tac att ccc agc agg gct gta tct ttg ttc ttc aac     2116
 Ala Pro Glu Thr Tyr Ile Pro Ser Arg Ala Val Ser Leu Phe Phe Asn
                 685                 690                 695

 tgg aag cag gaa ttc agg act ctg gag gtc aca ctc cgg gat ttc agc     2164
 Trp Lys Gln Glu Phe Arg Thr Leu Glu Val Thr Leu Arg Asp Phe Ser
             700                 705                 710

 aag ttg aat aag caa gat atc aga tat ctg ggg aaa ata ttc agc tct     2212
 Lys Leu Asn Lys Gln Asp Ile Arg Tyr Leu Gly Lys Ile Phe Ser Ser
         715                 720                 725

 gcc aca agc ctc agg ctg caa ata aag aga tgt gct ggt gtg gct gga     2260
 Ala Thr Ser Leu Arg Leu Gln Ile Lys Arg Cys Ala Gly Val Ala Gly
     730                 735                 740

 agc ctc agt ttg gtc ctc agc acc tgt aag aac att tat tct ctc atg     2308
 Ser Leu Ser Leu Val Leu Ser Thr Cys Lys Asn Ile Tyr Ser Leu Met
 745                 750                 755                 760

 gtg gaa gcc agt ccc ctc acc ata gaa gat gag agg cac atc aca tct     2356
 Val Glu Ala Ser Pro Leu Thr Ile Glu Asp Glu Arg His Ile Thr Ser
                 765                 770                 775

 gta aca aac ctg aaa acc ttg agt att cat gac cta cag aat caa cgg     2404
 Val Thr Asn Leu Lys Thr Leu Ser Ile His Asp Leu Gln Asn Gln Arg
             780                 785                 790

 ctg ccg ggt ggt ctg act gac agc ttg ggt aac ttg aag aac ctt aca     2452
 Leu Pro Gly Gly Leu Thr Asp Ser Leu Gly Asn Leu Lys Asn Leu Thr
         795                 800                 805

 aag ctc ata atg gat aac ata aag atg aat gaa gaa gat gct ata aaa     2500
 Lys Leu Ile Met Asp Asn Ile Lys Met Asn Glu Glu Asp Ala Ile Lys
     810                 815                 820

 cta gct gaa ggc ctg aaa aac ctg aag aag atg tgt tta ttt cat ttg     2548
 Leu Ala Glu Gly Leu Lys Asn Leu Lys Lys Met Cys Leu Phe His Leu
 825                 830                 835                 840

 acc cac ttg tct gac att gga gag gga atg gat tac ata gtc aag tct     2596
 Thr His Leu Ser Asp Ile Gly Glu Gly Met Asp Tyr Ile Val Lys Ser
                 845                 850                 855

 ctg tca agt gaa ccc tgt gac ctt gaa gaa att caa tta gtc tcc tgc     2644
 Leu Ser Ser Glu Pro Cys Asp Leu Glu Glu Ile Gln Leu Val Ser Cys
             860                 865                 870

 tgc ttg tct gca aat gca gtg aaa atc cta gct cag aat ctt cac aat     2692
 Cys Leu Ser Ala Asn Ala Val Lys Ile Leu Ala Gln Asn Leu His Asn
         875                 880                 885

 ttg gtc aaa ctg agc att ctt gat tta tca gaa aat tac ctg gaa aaa     2740
 Leu Val Lys Leu Ser Ile Leu Asp Leu Ser Glu Asn Tyr Leu Glu Lys
     890                 895                 900

 gat gga aat gaa gct ctt cat gaa ctg atc gac agg atg aac gtg cta     2788
 Asp Gly Asn Glu Ala Leu His Glu Leu Ile Asp Arg Met Asn Val Leu
 905                 910                 915                 920

 gaa cag ctc acc gca ctg atg ctg ccc tgg ggc tgt gac gtg caa ggc     2836
 Glu Gln Leu Thr Ala Leu Met Leu Pro Trp Gly Cys Asp Val Gln Gly
                 925                 930                 935

 agc ctg agc agc ctg ttg aaa cat ttg gag gag gtc cca caa ctc gtc     2884
 Ser Leu Ser Ser Leu Leu Lys His Leu Glu Glu Val Pro Gln Leu Val
             940                 945                 950

 aag ctt ggg ttg aaa aac tgg aga ctc aca gat aca gag att aga att     2932
 Lys Leu Gly Leu Lys Asn Trp Arg Leu Thr Asp Thr Glu Ile Arg Ile
         955                 960                 965

 tta ggt gca ttt ttt gga aag aac cct ctg aaa aac ttc cag cag ttg     2980
 Leu Gly Ala Phe Phe Gly Lys Asn Pro Leu Lys Asn Phe Gln Gln Leu
     970                 975                 980

 aat ttg gcg gga aat cgt gtg agc agt gat gga tgg ctt gcc ttc atg     3028
 Asn Leu Ala Gly Asn Arg Val Ser Ser Asp Gly Trp Leu Ala Phe Met
 985                 990                 995                1000

 ggt gta ttt gag aat ctt aag caa tta gtg ttt ttt gac ttt agt act     3076
 Gly Val Phe Glu Asn Leu Lys Gln Leu Val Phe Phe Asp Phe Ser Thr
                1005                1010                1015

 aaa gaa ttt cta cct gat cca gca tta gtc aga aaa ctt agc caa gtg     3124
 Lys Glu Phe Leu Pro Asp Pro Ala Leu Val Arg Lys Leu Ser Gln Val
            1020                1025                1030

 tta tcc aag tta act ttt ctg caa gaa gct agg ctt gtt ggg tgg caa     3172
 Leu Ser Lys Leu Thr Phe Leu Gln Glu Ala Arg Leu Val Gly Trp Gln
        1035                1040                1045

 ttt gat gat gat gat ctc agt gtt att aca ggt gct ttt aaa cta gta     3220
 Phe Asp Asp Asp Asp Leu Ser Val Ile Thr Gly Ala Phe Lys Leu Val
    1050                1055                1060

 act gct taaataaagt gtactcgaag ccaaaaaaaa aaaa                       3260
 Thr Ala 
1065





      <210> 67
      <211> 853
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (409)..(684)

      <400> 67
 ctctgtttcc acatgctttc tccagtatag gatttctcag ccttttcact attgacaatt     60

 ttggctggat aatcctttgt tgtggaggag ctctcctggg cattgcagat gttaggaaga    120

 attcctggcc tctttgccca gatccaaaat ctgggcaaag aaaaaatctt ctggaaagaa    180

 ttcagcattc tagatgccaa taaaaacact gatgtttcat ggaaggagat caaaatagca    240

 acattaacag gggtctggaa gaagttgatt ctgacttttg aaactgtcag tttcaaaatt    300

 tcattgtagg aagtaactgt ggatgtggta gaaacagcaa gagaacttga attagaagtg    360

 aaccctgaaa atgtgactag attgctgcta tctcatgatc aaatttaa atg gat gag     417
                                                      Met Asp Glu
                                                        1

 gag ttg ctt cat agg gat gaa caa aga aag tgg ttt ctt gag atg aga      465
 Glu Leu Leu His Arg Asp Glu Gln Arg Lys Trp Phe Leu Glu Met Arg
       5                  10                  15

 tct act cct ggt gaa gat gct gcg aac aac gtt gaa atg aca aca aag      513
 Ser Thr Pro Gly Glu Asp Ala Ala Asn Asn Val Glu Met Thr Thr Lys
  20                  25                  30                  35

 gac tta aac tat gac aga aac tta gtt gat aaa gca gtg gta ggg ttt      561
 Asp Leu Asn Tyr Asp Arg Asn Leu Val Asp Lys Ala Val Val Gly Phe
                  40                  45                  50

 gaa agg act gac tcc aat ttt gaa aga agt tgt act gtg ggt aaa cag      609
 Glu Arg Thr Asp Ser Asn Phe Glu Arg Ser Cys Thr Val Gly Lys Gln
              55                  60                  65

 cat tgc atg ata cag aga aat tgt tca tgg aaa gaa gag tac atg gat      657
 His Cys Met Ile Gln Arg Asn Cys Ser Trp Lys Glu Glu Tyr Met Asp
          70                  75                  80

 gca gca aac ttc att gtt gtc tta ttt taaga aattgccaca gccactccat      709
 Ala Ala Asn Phe Ile Val Val Leu Phe 
      85                  90

 ccttcagcaa ccaccaccct ggtctattag aaaccatcaa tatcaaggca agattctcca    769

 ccaacaaaaa gctatgactc actgatggct cagatgatca ttagcatttt tcagcaataa    829

 agtatttcta cattaaaaaa aaaa                                           853




      <210> 68
      <211> 2727
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2439)

      <400> 68
  atg agg aga gac ccc acg ccg ccc agg ggc ctc ccg cgg cag agg ccg      48
  Met Arg Arg Asp Pro Thr Pro Pro Arg Gly Leu Pro Arg Gln Arg Pro
    1               5                  10                  15

 acg ccg agc cca agg aca cgc tcc cgg gga cac caa agc caa agg cca       96
 Thr Pro Ser Pro Arg Thr Arg Ser Arg Gly His Gln Ser Gln Arg Pro
              20                  25                  30

 aag gcc aag tcc gag ccc cag ccc gcg ccc gcg gcg acc ccc gga ggc      144
 Lys Ala Lys Ser Glu Pro Gln Pro Ala Pro Ala Ala Thr Pro Gly Gly
          35                  40                  45

 cga agg gcg tgg gaa cca cgg gcg caa gcc ggc tgc cca ccc ccg ccc      192
 Arg Arg Ala Trp Glu Pro Arg Ala Gln Ala Gly Cys Pro Pro Pro Pro
      50                  55                  60

 cgg gcc gcc tct ccc agg aga tta gtg cag ggc gag cgg ccg gaa tcc      240
 Arg Ala Ala Ser Pro Arg Arg Leu Val Gln Gly Glu Arg Pro Glu Ser
  65                  70                  75                  80

 ggg aac cgt agc cga cag gca gct tac cca cgc cgc gcc agc cgg gca      288
 Gly Asn Arg Ser Arg Gln Ala Ala Tyr Pro Arg Arg Ala Ser Arg Ala
                  85                  90                  95

 cga acc tgc aca acg cga ctt cca cca acc ttg cgc cag cgc gca ctg      336
 Arg Thr Cys Thr Thr Arg Leu Pro Pro Thr Leu Arg Gln Arg Ala Leu
             100                 105                 110

 acg cag cgc cca tgc tcg gta ccc agg acc aat aga aag ctc cga agg      384
 Thr Gln Arg Pro Cys Ser Val Pro Arg Thr Asn Arg Lys Leu Arg Arg
         115                 120                 125

 gga cct ggg cca atc aca ttg cgc cgc cct gag tcg tgc tcc cgc ccc      432
 Gly Pro Gly Pro Ile Thr Leu Arg Arg Pro Glu Ser Cys Ser Arg Pro
     130                 135                 140

 gcg ttt gct acg gag gcc cac gac gcc cag gcg ctt ccg cga cca ccc      480
 Ala Phe Ala Thr Glu Ala His Asp Ala Gln Ala Leu Pro Arg Pro Pro
 145                 150                 155                 160

 gga gtg att gcc cgg cag agc gcg atg cat aga gct ctg gct gct tta      528
 Gly Val Ile Ala Arg Gln Ser Ala Met His Arg Ala Leu Ala Ala Leu
                 165                 170                 175

 aaa aat aaa cct cta aat cat gtt cac aag gta gtc aag gag cgt ctg      576
 Lys Asn Lys Pro Leu Asn His Val His Lys Val Val Lys Glu Arg Leu
             180                 185                 190

 tgc cct tgg ttg tgt tca cga caa cct gag cct ttc ggg gtc aaa ttc      624
 Cys Pro Trp Leu Cys Ser Arg Gln Pro Glu Pro Phe Gly Val Lys Phe
         195                 200                 205

 cat cat gcc cat tgt aaa aag ttt cat tcg aaa aat gga aat gac ctt      672
 His His Ala His Cys Lys Lys Phe His Ser Lys Asn Gly Asn Asp Leu
     210                 215                 220

 cat cca ctc ggt gga cca gtg ttc tct caa gta tct gac tgc gac agg      720
 His Pro Leu Gly Gly Pro Val Phe Ser Gln Val Ser Asp Cys Asp Arg
 225                 230                 235                 240

 ctt gaa caa aat gtt aaa aat gag gag agt cag atg ttt tac agg aga      768
 Leu Glu Gln Asn Val Lys Asn Glu Glu Ser Gln Met Phe Tyr Arg Arg
                 245                 250                 255

 ctg agc aac ttg act tca tca gaa gaa gtg cta agt ttt ata agc acg      816
 Leu Ser Asn Leu Thr Ser Ser Glu Glu Val Leu Ser Phe Ile Ser Thr
             260                 265                 270

 atg gaa acc ctg cct gac act atg gca gca gga gct tta caa cga att      864
 Met Glu Thr Leu Pro Asp Thr Met Ala Ala Gly Ala Leu Gln Arg Ile
         275                 280                 285

 tgt gaa gtg gaa aaa aag gat ggt gat caa ggg ctg cca aaa gaa ata      912
 Cys Glu Val Glu Lys Lys Asp Gly Asp Gln Gly Leu Pro Lys Glu Ile
     290                 295                 300

 ctg gag aat agc atc ttt caa gct tta tgc ttt cag ttt gaa aag gag      960
 Leu Glu Asn Ser Ile Phe Gln Ala Leu Cys Phe Gln Phe Glu Lys Glu
 305                 310                 315                 320

 ccc tca cag ctg tca aac act agt tta gtg act gct ttg caa gct ctg     1008
 Pro Ser Gln Leu Ser Asn Thr Ser Leu Val Thr Ala Leu Gln Ala Leu
                 325                 330                 335

 att ctg ttg cat gtg gat cct caa agt agc ctg ttg ctg aac ctg gtg     1056
 Ile Leu Leu His Val Asp Pro Gln Ser Ser Leu Leu Leu Asn Leu Val
             340                 345                 350

 gca gaa tgc caa aat cgt ctc aga aaa ggt ggc atg gaa gtt cgc aat     1104
 Ala Glu Cys Gln Asn Arg Leu Arg Lys Gly Gly Met Glu Val Arg Asn
         355                 360                 365

 ctt tgt att ctt ggg gaa agt ctg att aca ctg cac agt tca ggt tgt     1152
 Leu Cys Ile Leu Gly Glu Ser Leu Ile Thr Leu His Ser Ser Gly Cys
     370                 375                 380

 gtg aca cta gaa ctc att ata aat caa ctt caa ggt gaa aaa ttg gaa     1200
 Val Thr Leu Glu Leu Ile Ile Asn Gln Leu Gln Gly Glu Lys Leu Glu
 385                 390                 395                 400

 aca ttt acc ccg gag gat att gtg gcc ctt tat aga atc ttg cag gca     1248
 Thr Phe Thr Pro Glu Asp Ile Val Ala Leu Tyr Arg Ile Leu Gln Ala
                 405                 410                 415

 tgt act gaa aaa gtg gat gaa cac caa aca ttt tta aat aag ata aac     1296
 Cys Thr Glu Lys Val Asp Glu His Gln Thr Phe Leu Asn Lys Ile Asn
             420                 425                 430

 aac ttt tcc cta tca ata gtt tcc aac ctg agt cct aaa ttg att agc     1344
 Asn Phe Ser Leu Ser Ile Val Ser Asn Leu Ser Pro Lys Leu Ile Ser
         435                 440                 445

 caa atg ctc act gcc ctg gtg gtt ctt gat caa agt caa gca ttt cct     1392
 Gln Met Leu Thr Ala Leu Val Val Leu Asp Gln Ser Gln Ala Phe Pro
     450                 455                 460

 ctg att ata aaa ttg ggc aaa tat gtc gtg agg cat gtc cca cat ttc     1440
 Leu Ile Ile Lys Leu Gly Lys Tyr Val Val Arg His Val Pro His Phe
 465                 470                 475                 480

 act aac gag gag ctt agg aga gtc ttg gag gcg ttc ata tat ttt ggg     1488
 Thr Asn Glu Glu Leu Arg Arg Val Leu Glu Ala Phe Ile Tyr Phe Gly
                 485                 490                 495

 cac cat gac aca ttt ttt aca aaa gcc cta gag cat cgt gta gct gcg     1536
 His His Asp Thr Phe Phe Thr Lys Ala Leu Glu His Arg Val Ala Ala
             500                 505                 510

 gtg tgc ctc acg ttg gat cct gaa gtt gtc tgc agg gtc atg gag tac     1584
 Val Cys Leu Thr Leu Asp Pro Glu Val Val Cys Arg Val Met Glu Tyr
         515                 520                 525

 tgc agt aga gaa ctg att ctt tca aaa ccc atc ctc aat gca gtg gca     1632
 Cys Ser Arg Glu Leu Ile Leu Ser Lys Pro Ile Leu Asn Ala Val Ala
     530                 535                 540

 gaa act ttt gtt tgc caa aca gaa aaa ttt tca cct cgt cag att tct     1680
 Glu Thr Phe Val Cys Gln Thr Glu Lys Phe Ser Pro Arg Gln Ile Ser
 545                 550                 555                 560

 gcg tta atg gaa cca ttt ggg aaa ctc aat tat ttg cca cca aat gcc     1728
 Ala Leu Met Glu Pro Phe Gly Lys Leu Asn Tyr Leu Pro Pro Asn Ala
                 565                 570                 575

 tct gct tta ttt aga aag ctg gaa aac gtg cta ttc act cat ttc aat     1776
 Ser Ala Leu Phe Arg Lys Leu Glu Asn Val Leu Phe Thr His Phe Asn
             580                 585                 590

 tat ttt cca ccc aaa tca tta ttg aaa ctt ctt cat tca tgt tca ctt     1824
 Tyr Phe Pro Pro Lys Ser Leu Leu Lys Leu Leu His Ser Cys Ser Leu
         595                 600                 605

 aat gaa tgc cat cca gtc aac ttt ctg gca aaa ata ttc aag cct ctt     1872
 Asn Glu Cys His Pro Val Asn Phe Leu Ala Lys Ile Phe Lys Pro Leu
     610                 615                 620

 ttc ctt caa cgg ctg caa ggt aaa gaa tct cat ttg gac aca ttg agt     1920
 Phe Leu Gln Arg Leu Gln Gly Lys Glu Ser His Leu Asp Thr Leu Ser
 625                 630                 635                 640

 cgg gca caa ctg acc caa ctt ttc tta gcc tca gtc ctg gaa tgc cct     1968
 Arg Ala Gln Leu Thr Gln Leu Phe Leu Ala Ser Val Leu Glu Cys Pro
                 645                 650                 655

 ttc tat aag ggt cca aaa ctc ctt cct aaa tat caa gtg aag tca ttt     2016
 Phe Tyr Lys Gly Pro Lys Leu Leu Pro Lys Tyr Gln Val Lys Ser Phe
             660                 665                 670

 ctt acc cca tgc tgt tcc ctg gag acc cct gtg gat tct cag ctt tat     2064
 Leu Thr Pro Cys Cys Ser Leu Glu Thr Pro Val Asp Ser Gln Leu Tyr
         675                 680                 685

 aga tat gtg aag att ggg ctg act aac ctt tta gga gca aga tta tat     2112
 Arg Tyr Val Lys Ile Gly Leu Thr Asn Leu Leu Gly Ala Arg Leu Tyr
     690                 695                 700

 ttt gct cca aaa gtg ttg aca ccc tat tgt tat aca ata gat gtt gaa     2160
 Phe Ala Pro Lys Val Leu Thr Pro Tyr Cys Tyr Thr Ile Asp Val Glu
 705                 710                 715                 720

 att aaa tta gat gaa gaa gga ttt gta ttg cca tcc aca gct aat gaa     2208
 Ile Lys Leu Asp Glu Glu Gly Phe Val Leu Pro Ser Thr Ala Asn Glu
                 725                 730                 735

 gat atc cat aaa agg ata gca ctg tgt att gat ggt cca aaa agg ttt     2256
 Asp Ile His Lys Arg Ile Ala Leu Cys Ile Asp Gly Pro Lys Arg Phe
             740                 745                 750

 tgc tcc aat agc aaa cac tta ctg ggg aaa gaa gct att aaa caa aga     2304
 Cys Ser Asn Ser Lys His Leu Leu Gly Lys Glu Ala Ile Lys Gln Arg
         755                 760                 765

 cac cta cag tta ctc ggt tat caa gtt gtt cag atc ccc tat cat gag     2352
 His Leu Gln Leu Leu Gly Tyr Gln Val Val Gln Ile Pro Tyr His Glu
     770                 775                 780

 att ggg atg cta aaa tca aga cgt gaa ttg gtg gaa tat tta caa aga     2400
 Ile Gly Met Leu Lys Ser Arg Arg Glu Leu Val Glu Tyr Leu Gln Arg
 785                 790                 795                 800

 aaa ctg ttt tct caa aac act gtt cat tgg ttg caa gaa tgaatactga      2449
 Lys Leu Phe Ser Gln Asn Thr Val His Trp Leu Gln Glu 
                 805                 810

 cttcagaact caaacaatgg aagaacttgc atttttatgg aactcagtat taaaagaaaa   2509

 atataatgtg aattagccac tttgcagaat atgttctaga ctggtgatct gaaagcatct   2569

 gtagttttcc ttatactatg tatacattta ttgtggtaaa atttaaaatt aattttaatt   2629

 taatactagt gtcatagata ctttttgtac atcaaacaat tgatcatgtg ctgtaaagga   2689

 attcaatgaa taaatgttat ttttaagtaa aaaaaaaa                           2727




      <210> 69
      <211> 853
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (74)..(229)

      <400> 69
 aaattcgcgg ccgcgtcgac atggttctgt ggtgcagttt aagattaaga ggcatacacc     60

 acttagtaaa cta   atg aaa gcc tat tgt gaa cga cag gga ttg tca atg     109
                  Met Lys Ala Tyr Cys Glu Arg Gln Gly Leu Ser Met
                    1               5                  10

 agg cag atc aga ttc cga ttt gac ggg caa cca atc aat gaa aca gac      157
 Arg Gln Ile Arg Phe Arg Phe Asp Gly Gln Pro Ile Asn Glu Thr Asp
          15                  20                  25

 aca cct gca cag ttg gaa atg gag gat gaa gat aca att gat gtg ttc      205
 Thr Pro Ala Gln Leu Glu Met Glu Asp Glu Asp Thr Ile Asp Val Phe
      30                  35                  40

 caa cag cag acg gga ggt gtc tac tgaaaaggga acctgcttct ttactccaga     259
 Gln Gln Gln Thr Gly Gly Val Tyr 
  45                  50

 actctgttct ttaaagacca agattacatt ctcaattaga aaactgcaat ttggttccac    319

 cacatcctga ctactaccgt atagttttct ctattctttc atttccccct tccccattcc    379

 tttattgtac ataaagtaac tggtatatgt gcacaagcat attgcatttt tttttttttt    439

 taactaaaca gccaatggta tgttttgatt gacatcaagt ggagacggga tggggaaaaa    499

 tactgattct gtgaaaatac cccctttctc cattagtggc atgctcattc agctcttatc    559

 tttatattcc agtaagttat tttgctctca ctgttttaac aaaaaaaaaa aacaacaaca    619

 taaaaatcct tgcatacctt gttcaattgg agaattttaa tgtttttcat ttatcattgt    679

 aaaaccaagg acaattttat aacttttttg tacgtagctg ttacatgtag ggcaatctgt    739

 ctttaagtag ggataaatta ctctaaaaca aaaaagaatc ctagatagtt ttcccttcaa    799

 gtcaagcgtc ttgttgttta aataaacttc ttgtttaaaa tgaaaaaaaa aaaa          853




      <210> 70
      <211> 2072
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (339)..(1544)

      <400> 70
 gcgaaaactc gcctctgccc aaggctgtgc ggggcgtccg cccccgcact tcgctgattg     60

 gccgcactag cccgctcgtc acgctctttt gtctcagctg gcagaggata aaagccgccg    120

 cggctgcctt aggaacggcg ctgcctcgtc tctgctaccc ctggttgggc ggccctgcga    180

 agcagctcct tcgggcagcc ccgggtcgct tagcggccaa ggaggcttca gttctttgcc    240

 gcctgcaagg cggagaccag aaggcggaat ccacagctgg cgacgcggga gcatctgctg    300

 tccaccagcg gagcacagat accctatcgt cgtcagtc    atg gct agc atc att     353
                                              Met Ala Ser Ile Ile
                                                1               5

 gca cgt gtc ggt aac agc cgg cgg ctg aat gca ccc ttg ccg cct tgg      401
 Ala Arg Val Gly Asn Ser Arg Arg Leu Asn Ala Pro Leu Pro Pro Trp
                  10                  15                  20

 gcc cat tcc atg ctg agg tcc ctg ggg aga agt ctc ggt cct ata atg      449
 Ala His Ser Met Leu Arg Ser Leu Gly Arg Ser Leu Gly Pro Ile Met
              25                  30                  35

 gcc agc atg gca gac aga aac atg aag ttg ttc tcg ggg agg gtg gtg      497
 Ala Ser Met Ala Asp Arg Asn Met Lys Leu Phe Ser Gly Arg Val Val
          40                  45                  50

 cca gcc caa ggg gaa gaa acc ttt gaa aac tgg ctg acc caa gtc aat      545
 Pro Ala Gln Gly Glu Glu Thr Phe Glu Asn Trp Leu Thr Gln Val Asn
      55                  60                  65

 ggc gtc ctg cca gat tgg aat atg tct gag gag gaa aag ctc aag cgc      593
 Gly Val Leu Pro Asp Trp Asn Met Ser Glu Glu Glu Lys Leu Lys Arg
  70                  75                  80                  85

 ttg atg aaa acc ctt agg ggc cct gcc cgc gag gtc atg cgt gtg ctt      641
 Leu Met Lys Thr Leu Arg Gly Pro Ala Arg Glu Val Met Arg Val Leu
                  90                  95                 100

 cag gcg acc aac cct aac cta agt gtg gca gat ttc ttg cga gcc atg      689
 Gln Ala Thr Asn Pro Asn Leu Ser Val Ala Asp Phe Leu Arg Ala Met
             105                 110                 115

 aaa ttg gtg ttt ggg gag tct gaa agc agt gtg act gcc cat ggt aaa      737
 Lys Leu Val Phe Gly Glu Ser Glu Ser Ser Val Thr Ala His Gly Lys
         120                 125                 130

 ttt ttt aac acc cta caa gct caa ggg gag aaa gcc tcc ctt tat gtg      785
 Phe Phe Asn Thr Leu Gln Ala Gln Gly Glu Lys Ala Ser Leu Tyr Val
     135                 140                 145

 atc cgt tta gag gtg cag ctc cag aac gct att cag gca ggc att ata      833
 Ile Arg Leu Glu Val Gln Leu Gln Asn Ala Ile Gln Ala Gly Ile Ile
 150                 155                 160                 165

 gct gag aaa gat gca aac cgg act cgc ttg cag cag ctc ctt tta ggc      881
 Ala Glu Lys Asp Ala Asn Arg Thr Arg Leu Gln Gln Leu Leu Leu Gly
                 170                 175                 180

 ggt gag ctg agt agg gac ctc cga ctc aga ctt aag gat ttt ctc agg      929
 Gly Glu Leu Ser Arg Asp Leu Arg Leu Arg Leu Lys Asp Phe Leu Arg
             185                 190                 195

 atg tat gca aat gag cag gag cgg ctt ccc aac ttt ctg gag tta atc      977
 Met Tyr Ala Asn Glu Gln Glu Arg Leu Pro Asn Phe Leu Glu Leu Ile
         200                 205                 210

 aga atg gta agg gag gaa gag gat tgg gat gat gct ttt att aaa cgg     1025
 Arg Met Val Arg Glu Glu Glu Asp Trp Asp Asp Ala Phe Ile Lys Arg
     215                 220                 225

 aag cgt cca aaa agg tct gag tca atg gtg gag agg gca gtc agc cct     1073
 Lys Arg Pro Lys Arg Ser Glu Ser Met Val Glu Arg Ala Val Ser Pro
 230                 235                 240                 245

 gtg gca ttt cag ggc tcc cca ccg ata gtg atc ggc agt gct gac tgc     1121
 Val Ala Phe Gln Gly Ser Pro Pro Ile Val Ile Gly Ser Ala Asp Cys
                 250                 255                 260

 aat gtg ata gag ata gat gat acc ctc gac gac tcc gat gag gat gtg     1169
 Asn Val Ile Glu Ile Asp Asp Thr Leu Asp Asp Ser Asp Glu Asp Val
             265                 270                 275

 atc ctg gtg gag tct cag gac cct cca ctt cca tcc tgg ggt gcc cct     1217
 Ile Leu Val Glu Ser Gln Asp Pro Pro Leu Pro Ser Trp Gly Ala Pro
         280                 285                 290

 ccc ctc aga gac agg gcc aga cct cag gat gaa gtg ctg gtc att gat     1265
 Pro Leu Arg Asp Arg Ala Arg Pro Gln Asp Glu Val Leu Val Ile Asp
     295                 300                 305

 tcc ccc cac aat tcc agg gct cag ttt cct tcc acc agt ggt ggt tct     1313
 Ser Pro His Asn Ser Arg Ala Gln Phe Pro Ser Thr Ser Gly Gly Ser
 310                 315                 320                 325

 ggc tat aag aat aac ggt cct ggg gag atg cgt aga gcc agg aag cga     1361
 Gly Tyr Lys Asn Asn Gly Pro Gly Glu Met Arg Arg Ala Arg Lys Arg
                 330                 335                 340

 aaa cac aca atc cgc tgt tcg tat tgt ggt gag gaa ggc cac tca aaa     1409
 Lys His Thr Ile Arg Cys Ser Tyr Cys Gly Glu Glu Gly His Ser Lys
             345                 350                 355

 gaa acc tgt gac aac gag agt gac aag gcc cag gtt ttt gag aat ttg     1457
 Glu Thr Cys Asp Asn Glu Ser Asp Lys Ala Gln Val Phe Glu Asn Leu
         360                 365                 370

 atc atc act ctc cag gag ctg acc cat act gag atg gag agg tca aga     1505
 Ile Ile Thr Leu Gln Glu Leu Thr His Thr Glu Met Glu Arg Ser Arg
     375                 380                 385

 gtg gcc cct ggc gaa tac aat gac ttc tct gag cca ctg taagggacca      1554
 Val Ala Pro Gly Glu Tyr Asn Asp Phe Ser Glu Pro Leu 
 390                 395                 400

 cccccaggtt tcagtgaacc cttacctata ttcagcatcc agtagtggga aaactggggt   1614

 gggggtgggg tgggacttct aactgcatga attaatccac aaagcggcta tcttttgggg   1674

 tggagtagaa agggtcttgg ataccagccc attggaggga gatagcctga cctctgtcct   1734

 tgctccttct ccctgcagcc tacgggtctg ttttctgtgt gtgcccattt ccttgacagc   1794

 tttattcttt gtgaaagtgg tataatttat tgttaaatat ttgaacaata aaaaaggtac   1854

 aaaaagtgaa gtacaaatta cccaaatctc tccaccctta tataatcatt gtcaaccctt   1914

 tgatgagtga tatttcccta tacctatgta cccagataga tatatgcata gataaaagtg   1974

 atgaaatata agtgctgttc tatctgtatt ttttcaccaa acaatatatg ttgtgagctt   2034

 ctatgtcaat aaatatatat atcagcaaaa aaaaaaaa                           2072




      <210> 71
      <211> 1693
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (30)..(1643)

      <400> 71
 aaaggccctc cgaggctacg gtggttggg  atg gcg tac ctg agc gag tgt cgc      53
                                  Met Ala Tyr Leu Ser Glu Cys Arg
                                    1               5

 ctg cga ctg gag aaa ggc ttt atc ttg gac ggg gtg gct gtg agc acc      101
 Leu Arg Leu Glu Lys Gly Phe Ile Leu Asp Gly Val Ala Val Ser Thr
      10                  15                  20

 gct gcc cgc gct tat ggg cgc tct agg ccc aag ctg tgg tcg gcg att      149
 Ala Ala Arg Ala Tyr Gly Arg Ser Arg Pro Lys Leu Trp Ser Ala Ile
  25                  30                  35                  40

 ccg ccc tac aac gcg cag gag gac tac cac gcc cgc agc tac ttc cag      197
 Pro Pro Tyr Asn Ala Gln Glu Asp Tyr His Ala Arg Ser Tyr Phe Gln
                  45                  50                  55

 agt cac gtg gtt ccg ccc ctt ttg cgg aaa act gat cag agt ctc agg      245
 Ser His Val Val Pro Pro Leu Leu Arg Lys Thr Asp Gln Ser Leu Arg
              60                  65                  70

 aca ctt gtg gat tgc gtg ttc agc atg ggg aat gca agt gac tac gcc      293
 Thr Leu Val Asp Cys Val Phe Ser Met Gly Asn Ala Ser Asp Tyr Ala
          75                  80                  85

 tgg ttg gca tcc cat acc aca ccc agg gga atg ggg aag cca aga ggg      341
 Trp Leu Ala Ser His Thr Thr Pro Arg Gly Met Gly Lys Pro Arg Gly
      90                  95                 100

 cat tct ctc cag cag gtg act ggg cat gac cac tac aat gct gat ctg      389
 His Ser Leu Gln Gln Val Thr Gly His Asp His Tyr Asn Ala Asp Leu
 105                 110                 115                 120

 aaa ccg atc gat ggg ttc aat gga aga gag tct ggg aca tca ggc aac      437
 Lys Pro Ile Asp Gly Phe Asn Gly Arg Glu Ser Gly Thr Ser Gly Asn
                 125                 130                 135

 gtg gcg acc cga agc agc caa aat gag acc tcg aca gca aag gcc tcg      485
 Val Ala Thr Arg Ser Ser Gln Asn Glu Thr Ser Thr Ala Lys Ala Ser
             140                 145                 150

 aca gcg gag ccc gga cct ttg caa aat ctg caa gta acg cca acg tca      533
 Thr Ala Glu Pro Gly Pro Leu Gln Asn Leu Gln Val Thr Pro Thr Ser
         155                 160                 165

 caa agc gcg acc gag ccc tgt acg tca tcg ttc cgc gac gcc gac gcg      581
 Gln Ser Ala Thr Glu Pro Cys Thr Ser Ser Phe Arg Asp Ala Asp Ala
     170                 175                 180

 atg tgt gag aga tta ttg gaa gaa aac ctt gcc att gtt gaa gac atc      629
 Met Cys Glu Arg Leu Leu Glu Glu Asn Leu Ala Ile Val Glu Asp Ile
 185                 190                 195                 200

 ttg ccc tca cac gcc tgc ctt ggg tat gga agg aat ctg aag aag agc      677
 Leu Pro Ser His Ala Cys Leu Gly Tyr Gly Arg Asn Leu Lys Lys Ser
                 205                 210                 215

 tgg cac ccg cag acc ctc agg aat gtg gag aaa gtg tgg aag gcc gag      725
 Trp His Pro Gln Thr Leu Arg Asn Val Glu Lys Val Trp Lys Ala Glu
             220                 225                 230

 cag aag cat gag gct gag cgg aag aag att gag gag ctt cag cgg gag      773
 Gln Lys His Glu Ala Glu Arg Lys Lys Ile Glu Glu Leu Gln Arg Glu
         235                 240                 245

 ctg cga gaa gag aga gcc cgg gaa gag atg cag cgc tat gcg gag gat      821
 Leu Arg Glu Glu Arg Ala Arg Glu Glu Met Gln Arg Tyr Ala Glu Asp
     250                 255                 260

 gtt ggg gcc gtc aag aaa aaa gaa gaa aag ttg gac tgg atg tac cag      869
 Val Gly Ala Val Lys Lys Lys Glu Glu Lys Leu Asp Trp Met Tyr Gln
 265                 270                 275                 280

 ggt cct ggt ggg atg gtg aac cgt gac gag tac ctg ctg ggg cgc ccc      917
 Gly Pro Gly Gly Met Val Asn Arg Asp Glu Tyr Leu Leu Gly Arg Pro
                 285                 290                 295

 att gac aaa tat gtt ttt gag aag atg gag gag aag gag gca ggc tgc      965
 Ile Asp Lys Tyr Val Phe Glu Lys Met Glu Glu Lys Glu Ala Gly Cys
             300                 305                 310

 tct tct gaa aca gga ctt ctc cca ggc tct atc ttt gcc cca tca ggt     1013
 Ser Ser Glu Thr Gly Leu Leu Pro Gly Ser Ile Phe Ala Pro Ser Gly
         315                 320                 325

 gcc aat tcc ctt ctt gac atg gcc agc aag atc cgg gag gac cca ctc     1061
 Ala Asn Ser Leu Leu Asp Met Ala Ser Lys Ile Arg Glu Asp Pro Leu
     330                 335                 340

 ttc atc atc agg aag aag gag gag gag aaa aaa cga gag gta tta aat     1109
 Phe Ile Ile Arg Lys Lys Glu Glu Glu Lys Lys Arg Glu Val Leu Asn
 345                 350                 355                 360

 aat cca gtg aaa atg aag aaa atc aaa gaa ttg ttg caa atg agt ctg     1157
 Asn Pro Val Lys Met Lys Lys Ile Lys Glu Leu Leu Gln Met Ser Leu
                 365                 370                 375

 gaa aaa aag gag aag aag aaa aag aag gag aag aaa aag aag cac aag     1205
 Glu Lys Lys Glu Lys Lys Lys Lys Lys Glu Lys Lys Lys Lys His Lys
             380                 385                 390

 aaa cat aag cac aga agc tcg agt agt gat cgt tcc agc agc gag gat     1253
 Lys His Lys His Arg Ser Ser Ser Ser Asp Arg Ser Ser Ser Glu Asp
         395                 400                 405

 gag cac agt gca ggg agg cac aac tct aag gtg aac agg aga gag aca     1301
 Glu His Ser Ala Gly Arg His Asn Ser Lys Val Asn Arg Arg Glu Thr
     410                 415                 420

 ggc caa act agg agc cca tca cct aaa aaa gag gtc tac caa agg cga     1349
 Gly Gln Thr Arg Ser Pro Ser Pro Lys Lys Glu Val Tyr Gln Arg Arg
 425                 430                 435                 440

 cat gct ccc gga tac acc aga aaa ctc tct gca gag gaa tta gag cga     1397
 His Ala Pro Gly Tyr Thr Arg Lys Leu Ser Ala Glu Glu Leu Glu Arg
                 445                 450                 455

 aaa cgg caa gag atg atg gaa aac gcc aaa tgg agg gag gag gag aga     1445
 Lys Arg Gln Glu Met Met Glu Asn Ala Lys Trp Arg Glu Glu Glu Arg
             460                 465                 470

 ctg aac atc ctc aag agg cat gct aag gat gag gaa cgg gag cag agg     1493
 Leu Asn Ile Leu Lys Arg His Ala Lys Asp Glu Glu Arg Glu Gln Arg
         475                 480                 485

 cta gag aag ctg gac tcc cgg gat ggg aag ttc atc cac cgc atg aag     1541
 Leu Glu Lys Leu Asp Ser Arg Asp Gly Lys Phe Ile His Arg Met Lys
     490                 495                 500

 ctg gag agt gca tct act tcc tcc ctg gag gat cgg gtg aag cgg aat     1589
 Leu Glu Ser Ala Ser Thr Ser Ser Leu Glu Asp Arg Val Lys Arg Asn
 505                 510                 515                 520

 atc tac tct tta cag aga act tcg gta gct ctg gag aag aac ttt atg     1637
 Ile Tyr Ser Leu Gln Arg Thr Ser Val Ala Leu Glu Lys Asn Phe Met
                 525                 530                 535

 aaa aga tgaaaactgt cccctctctt attggttttc ctgcattttc cagggaagct      1693
 Lys Arg 






      <210> 72
      <211> 2266
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (30)..(1271)

      <400> 72
 aaaggccctc cgaggctacg gtggttggg  atg gcg tac ctg agc gag tgt cgc      53
                                  Met Ala Tyr Leu Ser Glu Cys Arg
                                    1               5

 ctg cga ctg gag aaa ggc ttt atc ttg gac ggg gtg gct gtg agc acc      101
 Leu Arg Leu Glu Lys Gly Phe Ile Leu Asp Gly Val Ala Val Ser Thr
      10                  15                  20

 gct gcc cgc gct tat ggg cgc tct agg ccc aag ctg tgg tcg gcg att      149
 Ala Ala Arg Ala Tyr Gly Arg Ser Arg Pro Lys Leu Trp Ser Ala Ile
  25                  30                  35                  40

 ccg ccc tac aac gcg cag gag gac tac cac gcc cgc agc tac ttc cag      197
 Pro Pro Tyr Asn Ala Gln Glu Asp Tyr His Ala Arg Ser Tyr Phe Gln
                  45                  50                  55

 agt cac gtg gtt ccg ccc ctt ttg cgg aaa act gat cag agt ctc agg      245
 Ser His Val Val Pro Pro Leu Leu Arg Lys Thr Asp Gln Ser Leu Arg
              60                  65                  70

 aca ctt gtg gat tgc gtg ttc agc atg ggg aat gca agt gac tac gcc      293
 Thr Leu Val Asp Cys Val Phe Ser Met Gly Asn Ala Ser Asp Tyr Ala
          75                  80                  85

 tgg ttg gca tcc cat acc aca ccc agg gga atg ggg aag cca aga ggg      341
 Trp Leu Ala Ser His Thr Thr Pro Arg Gly Met Gly Lys Pro Arg Gly
      90                  95                 100

 cat tct ctc cag cag gtg act ggg cat gac cac tac aat gct gat ctg      389
 His Ser Leu Gln Gln Val Thr Gly His Asp His Tyr Asn Ala Asp Leu
 105                 110                 115                 120

 aaa ccg atc gat ggg ttc aat gga aga gag tct ggg aca tca ggc aac      437
 Lys Pro Ile Asp Gly Phe Asn Gly Arg Glu Ser Gly Thr Ser Gly Asn
                 125                 130                 135

 gtg gcg acc cga agc agc caa aat gag acc tcg aca gca aag gcc tcg      485
 Val Ala Thr Arg Ser Ser Gln Asn Glu Thr Ser Thr Ala Lys Ala Ser
             140                 145                 150

 aca gcg gag ccc gga cct ttg caa aat ctg caa gta acg cca acg tca      533
 Thr Ala Glu Pro Gly Pro Leu Gln Asn Leu Gln Val Thr Pro Thr Ser
         155                 160                 165

 caa agc gcg acc gag ccc tgt acg tca tcg ttc cgc gac gcc gac gcg      581
 Gln Ser Ala Thr Glu Pro Cys Thr Ser Ser Phe Arg Asp Ala Asp Ala
     170                 175                 180

 atg tgt gag aga tta ttg gaa gaa aac ctt gcc att gtt gaa gac atc      629
 Met Cys Glu Arg Leu Leu Glu Glu Asn Leu Ala Ile Val Glu Asp Ile
 185                 190                 195                 200

 ttg ccc tca cac gcc tgc ctt ggg tat gga agg aat ctg aag aag agc      677
 Leu Pro Ser His Ala Cys Leu Gly Tyr Gly Arg Asn Leu Lys Lys Ser
                 205                 210                 215

 tgg cac ccg cag acc ctc agg aat gtg gag aaa gtg tgg aag gcc gag      725
 Trp His Pro Gln Thr Leu Arg Asn Val Glu Lys Val Trp Lys Ala Glu
             220                 225                 230

 cag aag cat gag gct gag cgg aag aag att gag gag ctt cag cgg gag      773
 Gln Lys His Glu Ala Glu Arg Lys Lys Ile Glu Glu Leu Gln Arg Glu
         235                 240                 245

 ctg cga gaa gag aga gcc cgg gaa gag atg cag cgc tat gcg gag gat      821
 Leu Arg Glu Glu Arg Ala Arg Glu Glu Met Gln Arg Tyr Ala Glu Asp
     250                 255                 260

 gtt ggg gcc gtc aag aaa aaa gaa gaa aag ttg gac tgg atg tac cag      869
 Val Gly Ala Val Lys Lys Lys Glu Glu Lys Leu Asp Trp Met Tyr Gln
 265                 270                 275                 280

 ggt cct ggt ggg atg gtg aac cgt gac gag tac ctg ctg ggg cgc ccc      917
 Gly Pro Gly Gly Met Val Asn Arg Asp Glu Tyr Leu Leu Gly Arg Pro
                 285                 290                 295

 att gac aaa tat gtt ttt gag aag atg gag gag aag gag gca ggc tgc      965
 Ile Asp Lys Tyr Val Phe Glu Lys Met Glu Glu Lys Glu Ala Gly Cys
             300                 305                 310

 tct tct gaa aca gga ctt ctc cca ggc tct atc ttt gcc cca tca ggt     1013
 Ser Ser Glu Thr Gly Leu Leu Pro Gly Ser Ile Phe Ala Pro Ser Gly
         315                 320                 325

 gcc aat tcc ctt ctt gac atg gcc agc aag atc cgg gag gac cca ctc     1061
 Ala Asn Ser Leu Leu Asp Met Ala Ser Lys Ile Arg Glu Asp Pro Leu
     330                 335                 340

 ttc atc atc agg aag aag gag gag gag aaa aaa cga gag gta tta aat     1109
 Phe Ile Ile Arg Lys Lys Glu Glu Glu Lys Lys Arg Glu Val Leu Asn
 345                 350                 355                 360

 aat cca gtg aaa atg aag aaa atc aaa gaa ttg ttg caa atg agt ctg     1157
 Asn Pro Val Lys Met Lys Lys Ile Lys Glu Leu Leu Gln Met Ser Leu
                 365                 370                 375

 gaa aaa aag gag aag aag aaa aag aag gag aag aaa aag aag cac aag     1205
 Glu Lys Lys Glu Lys Lys Lys Lys Lys Glu Lys Lys Lys Lys His Lys
             380                 385                 390

 aaa cat aag cac aga agc tcg agt agt gat cgt tcc agc agc gag gat     1253
 Lys His Lys His Arg Ser Ser Ser Ser Asp Arg Ser Ser Ser Glu Asp
         395                 400                 405

 gag cac agt gca caa ctc taaggt gaacaggaga gagacaggcc aaactaggag     1307
 Glu His Ser Ala Gln Leu 
     410

 cccatcacct aaaaaagagg tctaccaaag gcgacatgct cccggataca ccagaaaact   1367

 ctctgcagag gaattagagc gaaaacggca agagatgatg gaaaacgcca aatggaggga   1427

 ggaggagaga ctgaacatcc tcaagaggca tgctaaggat gaggaacggg agcagaggct   1487

 agagaagctg gactcccggg atgggaagtt catccaccgc atgaagctgg agagtgcatc   1547

 tacttcctcc ctggaggatc gggtgaagcg gaatatctac tctttacaga gaacttcggt   1607

 agctctggag aagaacttta tgaaaagatg aaaactgtcc cctctcttat tggttttcct   1667

 gcattttcca gggaagctgc tgacccctta attctcttta taagagttca aatgacttct   1727

 ttcacagatg tcaaaccacc agtgttcaaa gtgaccctgc ttcattgagt cctgaaacag   1787

 ctcacttcct ttgagagcta gtgtgacttg ctttgtggga cactcagtaa ctttgggttt   1847

 tgactcttta acgggtgggc actggaccat ctcggtggga gtgcttgtgc cactctggaa   1907

 ggctgttccc tggggttgtg atgtttatca tgccacttcc ttcttacctg tgccaacaga   1967

 cctatttcac tgcctcagcg tacaccagac ccttcagaaa cctctctggt gtcacccaga   2027

 tagattgtgc ttactgagac aaatgaacgt ttacttgatt tagaagataa tgtgacagaa   2087

 tgatgtcagg ttaggtcaaa gccaagggag tgacagaatc tggaaaatca aacaatacaa   2147

 aaagccctaa atgaactgtt aactatttga tctttggatg taaaattgta atgcgtatat   2207

 gtacaaatgt acaattttta catgctttta aaaaaggtta gctttgtgaa aaaaaaaaa    2266




      <210> 73
      <211> 2125
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (334)..(1980)

      <400> 73
 gcacgaggtg tcattcctga ctgaggctgt tgtatctgtc aaaagagagg agaggtaggg     60

 ggcattctga aaaatgatca ctcatggctt gcaggagcaa gagccagaca ggactttgca    120

 actggcagct ttctgagtgc ataagacctc cacctctaga ctagctcttc agtcatggtt    180

 agccccttca gtccattatc ctccaataca atgcccatgc cttctggggc tttcagctaa    240

 gttttgttta aaaaatgtgg gttttttttt tgccaattca ttaaggcttt tccctttgtt    300

 ttctcctgct ggtggttcag agttaaattc agt atg aat aag aga ggg aaa tat     354
                                      Met Asn Lys Arg Gly Lys Tyr
                                        1               5

 aca aca ctg aat ttg gag gag aaa atg aag gtt cta agt aga att gaa      402
 Thr Thr Leu Asn Leu Glu Glu Lys Met Lys Val Leu Ser Arg Ile Glu
          10                  15                  20

 gct gga cga tca ctt aaa agt gta atg gat gaa ttt gga atc agt aag      450
 Ala Gly Arg Ser Leu Lys Ser Val Met Asp Glu Phe Gly Ile Ser Lys
      25                  30                  35

 tca aca ttt tat gac att aaa aaa aat aag aag tta att ctg gac ttt      498
 Ser Thr Phe Tyr Asp Ile Lys Lys Asn Lys Lys Leu Ile Leu Asp Phe
  40                  45                  50                  55

 gta ctg aag cag gac atg cca tta gta ggg gct gag aag aga aag agg      546
 Val Leu Lys Gln Asp Met Pro Leu Val Gly Ala Glu Lys Arg Lys Arg
                  60                  65                  70

 aca acg gga gcc aaa tat ggt gat gta gat gat gcg gtc tac atg tgg      594
 Thr Thr Gly Ala Lys Tyr Gly Asp Val Asp Asp Ala Val Tyr Met Trp
              75                  80                  85

 tac caa cag aaa cgc tca gcc ggt gtt ccg gta aga ggc gtg gag ctt      642
 Tyr Gln Gln Lys Arg Ser Ala Gly Val Pro Val Arg Gly Val Glu Leu
          90                  95                 100

 cag gct gct gca gag aga ttt gca cgg tgt ttt ggg cga aca gat ttc      690
 Gln Ala Ala Ala Glu Arg Phe Ala Arg Cys Phe Gly Arg Thr Asp Phe
     105                 110                 115

 aaa gct agc act ggt tgg ctt ttt aga ttt cga aat cgg cat gca att      738
 Lys Ala Ser Thr Gly Trp Leu Phe Arg Phe Arg Asn Arg His Ala Ile
 120                 125                 130                 135

 ggg aac cga aaa gga tgt ggg gaa caa gtc cta agt tca gtt tct gaa      786
 Gly Asn Arg Lys Gly Cys Gly Glu Gln Val Leu Ser Ser Val Ser Glu
                 140                 145                 150

 aat gtt gag cca ttt cga caa aaa ctg tcc atg ata atc aaa gag gag      834
 Asn Val Glu Pro Phe Arg Gln Lys Leu Ser Met Ile Ile Lys Glu Glu
             155                 160                 165

 aaa ctg tgt cta gct cag cta tac agt ggg gat gaa aca gac ctc ttt      882
 Lys Leu Cys Leu Ala Gln Leu Tyr Ser Gly Asp Glu Thr Asp Leu Phe
         170                 175                 180

 tgg aag tca atg cca gaa aat tct cag gca agt agg aaa gat atc tgc      930
 Trp Lys Ser Met Pro Glu Asn Ser Gln Ala Ser Arg Lys Asp Ile Cys
     185                 190                 195

 cta cca ggg aag aaa ata aac aaa gaa agg ttg tct gcc ttt tta tgt      978
 Leu Pro Gly Lys Lys Ile Asn Lys Glu Arg Leu Ser Ala Phe Leu Cys
 200                 205                 210                 215

 gca aat gca gac gga act cat aaa tta aag tca atc att att gga aaa     1026
 Ala Asn Ala Asp Gly Thr His Lys Leu Lys Ser Ile Ile Ile Gly Lys
                 220                 225                 230

 tca aaa ctg ccc aaa agt gtg aaa gag gac aca agt aca ttg cct gtg     1074
 Ser Lys Leu Pro Lys Ser Val Lys Glu Asp Thr Ser Thr Leu Pro Val
             235                 240                 245

 ata tat aaa ccc agt aaa gat gtt tgg ttc acc aga gaa ttg ttt tca     1122
 Ile Tyr Lys Pro Ser Lys Asp Val Trp Phe Thr Arg Glu Leu Phe Ser
         250                 255                 260

 gaa tgg ttt ttt caa aac ttt gtt cct gag gtc cga cat ttt caa ctt     1170
 Glu Trp Phe Phe Gln Asn Phe Val Pro Glu Val Arg His Phe Gln Leu
     265                 270                 275

 aat gtt cta aga ttt cat gac gag gac gtc agg gca ttg tta ctt ctg     1218
 Asn Val Leu Arg Phe His Asp Glu Asp Val Arg Ala Leu Leu Leu Leu
 280                 285                 290                 295

 gac agt tgc ccg gct cat cct tcc tct gaa tcc cta acc agt gag gat     1266
 Asp Ser Cys Pro Ala His Pro Ser Ser Glu Ser Leu Thr Ser Glu Asp
                 300                 305                 310

 ggt cga ata aaa tgt atg ttc ttc ccc cat aac act tca acc ttg att     1314
 Gly Arg Ile Lys Cys Met Phe Phe Pro His Asn Thr Ser Thr Leu Ile
             315                 320                 325

 caa cca atg aat caa ggt gtg atc ttg agc tgc aaa cgg ctg tat aga     1362
 Gln Pro Met Asn Gln Gly Val Ile Leu Ser Cys Lys Arg Leu Tyr Arg
         330                 335                 340

 tgg aag caa ctt gaa gag agt ctt gta ata ttt gaa gaa agt gat gat     1410
 Trp Lys Gln Leu Glu Glu Ser Leu Val Ile Phe Glu Glu Ser Asp Asp
     345                 350                 355

 gag caa gag aaa gga gat aaa gga gtt tcc aaa att aaa atc tac aat     1458
 Glu Gln Glu Lys Gly Asp Lys Gly Val Ser Lys Ile Lys Ile Tyr Asn
 360                 365                 370                 375

 ata aaa agt gca att ttt aac tgg gca aaa agt tgg gaa gaa gta aaa     1506
 Ile Lys Ser Ala Ile Phe Asn Trp Ala Lys Ser Trp Glu Glu Val Lys
                 380                 385                 390

 caa ata acc ata gca aat gca tgg gaa aat ctt ctt tac aaa aag gaa     1554
 Gln Ile Thr Ile Ala Asn Ala Trp Glu Asn Leu Leu Tyr Lys Lys Glu
             395                 400                 405

 cct gaa tat gat ttt caa ggc tta gaa cat ggg gat tat aga gaa att     1602
 Pro Glu Tyr Asp Phe Gln Gly Leu Glu His Gly Asp Tyr Arg Glu Ile
         410                 415                 420

 ctt gaa aaa tgt ggg gag ttg gaa act aag ttg gat gat gat agg gtg     1650
 Leu Glu Lys Cys Gly Glu Leu Glu Thr Lys Leu Asp Asp Asp Arg Val
     425                 430                 435

 tgg tta aat gga gat gaa gaa aag ggt tgt ctc cta aaa acc aaa ggt     1698
 Trp Leu Asn Gly Asp Glu Glu Lys Gly Cys Leu Leu Lys Thr Lys Gly
 440                 445                 450                 455

 gga ata aca aag gaa gtt gtt caa aaa gga gga gaa gct gag aag cag     1746
 Gly Ile Thr Lys Glu Val Val Gln Lys Gly Gly Glu Ala Glu Lys Gln
                 460                 465                 470

 act gct gaa ttt aaa tta tct gct gta aga gag agt ttg gac tac ctt     1794
 Thr Ala Glu Phe Lys Leu Ser Ala Val Arg Glu Ser Leu Asp Tyr Leu
             475                 480                 485

 ctt gac ttt gtt gat gcc aca cct gag ttt cag aga ttc cac ttc aca     1842
 Leu Asp Phe Val Asp Ala Thr Pro Glu Phe Gln Arg Phe His Phe Thr
         490                 495                 500

 ctg aaa gag atg caa caa gaa ata gtc aag aaa cag ttc cag agt aaa     1890
 Leu Lys Glu Met Gln Gln Glu Ile Val Lys Lys Gln Phe Gln Ser Lys
     505                 510                 515

 atc cat tct aga att ggt agc ttt ttg aaa cct agg cct cat aat att     1938
 Ile His Ser Arg Ile Gly Ser Phe Leu Lys Pro Arg Pro His Asn Ile
 520                 525                 530                 535

 aag gac tcc ttc agt ggg cct tca act tct ggt tct aat cat tagattt     1987
 Lys Asp Ser Phe Ser Gly Pro Ser Thr Ser Gly Ser Asn His 
                 540                 545

 tgtgtttaaa gatttctgcc attatatgat gtaggccagc tgtgaattgt cttgttttag   2047

 caactgacat tattttgtat atcagtgccc atttatataa tggttataaa atttacagtt   2107

 tgaaaataaa aaaaaaaa                                                 2125




      <210> 74
      <211> 2214
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(897)

      <400> 74
  atg ggc cat gtg agt agt gac gat ggg cac agt gat gag gat gag ctg      48
  Met Gly His Val Ser Ser Asp Asp Gly His Ser Asp Glu Asp Glu Leu
    1               5                  10                  15

 agg aaa tcc ctg tct gag ctg gtg gat gac aag ttc ggg aca ggc acg       96
 Arg Lys Ser Leu Ser Glu Leu Val Asp Asp Lys Phe Gly Thr Gly Thr
              20                  25                  30

 aag aag gtg acg cga atc ctg gat ggt ggc aac ccc ttc ctg gat gtc      144
 Lys Lys Val Thr Arg Ile Leu Asp Gly Gly Asn Pro Phe Leu Asp Val
          35                  40                  45

 cca cag gcg ctc agt gcc acc acc tac aag cac ggc gtc ctg acc cgg      192
 Pro Gln Ala Leu Ser Ala Thr Thr Tyr Lys His Gly Val Leu Thr Arg
      50                  55                  60

 aag act cac gct gac atg gat ggc aag agg acg ccc cgt ggg agg cgt      240
 Lys Thr His Ala Asp Met Asp Gly Lys Arg Thr Pro Arg Gly Arg Arg
  65                  70                  75                  80

 ggc tgg aag aaa ttc tac gca gtg ctc aaa ggg acc atc ctg tac ctg      288
 Gly Trp Lys Lys Phe Tyr Ala Val Leu Lys Gly Thr Ile Leu Tyr Leu
                  85                  90                  95

 cag aag gtg aga gac tgc ccc aga gac ctt act cac cca ggg gcc tct      336
 Gln Lys Val Arg Asp Cys Pro Arg Asp Leu Thr His Pro Gly Ala Ser
             100                 105                 110

 gac tac agc aag aag tcc aac gtg ctg aag ctt aag aca gcc gac tgg      384
 Asp Tyr Ser Lys Lys Ser Asn Val Leu Lys Leu Lys Thr Ala Asp Trp
         115                 120                 125

 agg gta ttc ctc ttc cag gca ccg agc aag gaa gaa atg ctg tcc tgg      432
 Arg Val Phe Leu Phe Gln Ala Pro Ser Lys Glu Glu Met Leu Ser Trp
     130                 135                 140

 atc ctc agg atc aac ctg gtg gca gcc att ttc tct gcc ccg gcc ttc      480
 Ile Leu Arg Ile Asn Leu Val Ala Ala Ile Phe Ser Ala Pro Ala Phe
 145                 150                 155                 160

 cca gcc gct gtc agc tcc atg aag aag ttc tgt cgg ccc ctg ctg ccc      528
 Pro Ala Ala Val Ser Ser Met Lys Lys Phe Cys Arg Pro Leu Leu Pro
                 165                 170                 175

 tcc tgc acc acc cgc ctc tgc cag gag gag caa ctg cgg tct cat gag      576
 Ser Cys Thr Thr Arg Leu Cys Gln Glu Glu Gln Leu Arg Ser His Glu
             180                 185                 190

 aat aag ttg agg cag ctg act gcg gag ctg gcc gaa cac agg tgt cac      624
 Asn Lys Leu Arg Gln Leu Thr Ala Glu Leu Ala Glu His Arg Cys His
         195                 200                 205

 cca gtc gag agg ggc atc aag tcc aag gag gcc gag gag tac cgg ttg      672
 Pro Val Glu Arg Gly Ile Lys Ser Lys Glu Ala Glu Glu Tyr Arg Leu
     210                 215                 220

 aag gag cac tat ctc acc ttc gag aaa agc cgt tat gag acc tat atc      720
 Lys Glu His Tyr Leu Thr Phe Glu Lys Ser Arg Tyr Glu Thr Tyr Ile
 225                 230                 235                 240

 cac ctc ctg gct atg aaa atc aaa gtg ggc tca gat gat ctg gag cgg      768
 His Leu Leu Ala Met Lys Ile Lys Val Gly Ser Asp Asp Leu Glu Arg
                 245                 250                 255

 att gag gcc cgg ctg gcc act ctg gaa ggg gat gac cct tct ctc cgg      816
 Ile Glu Ala Arg Leu Ala Thr Leu Glu Gly Asp Asp Pro Ser Leu Arg
             260                 265                 270

 aag aca cat tca agc cct gcc ctc agc cag ggc cat gtg act ggc agc      864
 Lys Thr His Ser Ser Pro Ala Leu Ser Gln Gly His Val Thr Gly Ser
         275                 280                 285

 aaa acc aca aag gat gcc act ggg cct gat act tagctgac atggatttgc      915
 Lys Thr Thr Lys Asp Ala Thr Gly Pro Asp Thr 
     290                 295

 agaccccagg gtgggcagat gtctccagtg gggtcagtga gcacaattcc agccaggggc    975

 cacttggacc aagctccagt cagttgatgg gcagctagag gggtgcagaa agcctgtggg   1035

 cccaggagat ggagatgccg tttgtggcgt tgatctcctt gcgtccttgg gcatctccgg   1095

 gcatcagacc ctctccctgg cccttgtttt cctctccacc atggagcctc attttgtagg   1155

 ccagttgtgt gcatgctcta gacaccacct cgctggagaa gctggaaggg ctgttgtctt   1215

 cccaggtctt tctcttctca tcaagctcct ctcctcatct tttttgtgtg tgagggcagg   1275

 tcttgactct aggtctcagc tggaacccca ccctttctcc tcctccttcc tctgagttga   1335

 ccagcagcag gtctgccgac caccagcacc atcctctcct cccagcagcc tccagaacca   1395

 tgcccaggtc tcctgcctca catcacaata atctgggacc caggcttgtg ccctttcagt   1455

 gtaaagctga ctccatcaca tgtgcatcca cttcttttca tccattgaga tcacactgcc   1515

 tcctttttat acagacacaa atatacatct ataagaataa tatatacata aggaacccct   1575

 gaaagatggt tttggaactg gaatcagtta gaggatgaaa tcagataaag gaaaagccta   1635

 ttttggagct tcccctgtta ggaaggatgg ctgcacctgg ccccctggca ttcctgacgc   1695

 tctaggaggg aagggggagg cagtgctggc ctcccttgcc ctgtttttcc ctcttccagc   1755

 tgacctgtga cttatactgc tcttaccgat gatacttttg gaaaaaatag agcgtgtatg   1815

 caccgccccg tttgtcccat ggatatcctg gggtgtgagt cggatgggac cacggccctg   1875

 tttatatttg ggtctttatg ttggtgctgc caggtctctg agctccagag gtggcctctt   1935

 ggacagatct actgctatag gaataaaaga cactctgtct cgcaaatggc cgcttgtcaa   1995

 caagcccaaa gatgcttgtc ggaggacggt tatggaagcc cttaattctt ggttgtggga   2055

 aaaggtggaa tgacaagtta ttgattgttt ttctgtcgct atttctttca tttgtctagt   2115

 gaatcagaaa ggcttagcaa ggccacatct gggaagagtg gagaaatttg ccacttgacg   2175

 atcacggatt agctagcacc tttaagccct gcatttctc                          2214




      <210> 75
      <211> 979
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (295)..(933)

      <400> 75
 agatagtgcg gcggcccaag cgtcgcgtct acccggggga ttacagtaac ccggctgtca     60

 gtgatgagtc agagtgcgtg gtgctgatgc tgctgccatt tcatcacctt tgcgagcgca    120

 gcatccatcc ctccgctctc ccggcgcctg ggcctaccca gcttcgggct cccaggccag    180

 cgatgcgctc gcggctgagc tagatcctgc cgagccgcgc tctctgaggc gtcggcgggg    240

 cgccccctcc cgccgtcccc ggtccgggcc aaggagacct gcagagccgc ggcc  atg     297
                                                              Met
                                                                1

 gag gcc atc tgg ctg tac cag ttc cgg ctc att gtc atc ggg gat tcc      345
 Glu Ala Ile Trp Leu Tyr Gln Phe Arg Leu Ile Val Ile Gly Asp Ser
               5                  10                  15

 aca gtg ggc aag tcc tgc ctg atc cgc cgc ttc acc gag ggt cgc ttt      393
 Thr Val Gly Lys Ser Cys Leu Ile Arg Arg Phe Thr Glu Gly Arg Phe
          20                  25                  30

 gcc cag gtt tct gac ccc acc gtg ggg gtg gat ttt ttc tcc cgc ttg      441
 Ala Gln Val Ser Asp Pro Thr Val Gly Val Asp Phe Phe Ser Arg Leu
      35                  40                  45

 gtg gag atc gag cca gga aaa cgc atc aag ctc cag atc tgg gat acc      489
 Val Glu Ile Glu Pro Gly Lys Arg Ile Lys Leu Gln Ile Trp Asp Thr
  50                  55                  60                  65

 gcg ggt caa gag agg ttc aga tcc atc act cgc gcc tac tac agg aac      537
 Ala Gly Gln Glu Arg Phe Arg Ser Ile Thr Arg Ala Tyr Tyr Arg Asn
                  70                  75                  80

 tca gta ggt ggt ctt ctc tta ttt gac att acc aac cgc agg tcc ttc      585
 Ser Val Gly Gly Leu Leu Leu Phe Asp Ile Thr Asn Arg Arg Ser Phe
              85                  90                  95

 cag aat gtc cat gag tgg tta gaa gag acc aaa gta cac gtt cag ccc      633
 Gln Asn Val His Glu Trp Leu Glu Glu Thr Lys Val His Val Gln Pro
         100                 105                 110

 tac caa att gta ttt gtt ctg gtg ggt cac aag tgt gac ctg gat aca      681
 Tyr Gln Ile Val Phe Val Leu Val Gly His Lys Cys Asp Leu Asp Thr
     115                 120                 125

 cag agg caa gtg act cgc cac gag gcc gag aaa ctg gct gct gca tac      729
 Gln Arg Gln Val Thr Arg His Glu Ala Glu Lys Leu Ala Ala Ala Tyr
 130                 135                 140                 145

 ggc atg aag tac att gaa acg tca gcc cga gat gcc att aat gtg gag      777
 Gly Met Lys Tyr Ile Glu Thr Ser Ala Arg Asp Ala Ile Asn Val Glu
                 150                 155                 160

 aaa gcc ttc aca gac ctg aca aga gac ata tat gag ctg gtt aaa agg      825
 Lys Ala Phe Thr Asp Leu Thr Arg Asp Ile Tyr Glu Leu Val Lys Arg
             165                 170                 175

 ggg gag att aca atc cag gag ggc tgg gaa ggg gtg aag agt gga ttt      873
 Gly Glu Ile Thr Ile Gln Glu Gly Trp Glu Gly Val Lys Ser Gly Phe
         180                 185                 190

 gta cca aat gtg gtt cac tct tca gaa gag gtt gtc aaa tca gag agg      921
 Val Pro Asn Val Val His Ser Ser Glu Glu Val Val Lys Ser Glu Arg
     195                 200                 205

 aga tgt ttg tgc tag tcagttcttt tatttccaaa acatgctctc ctacttgaac      976
 Arg Cys Leu Cys 
 210

 tga                                                                  979




      <210> 76
      <211> 1884
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (199)..(624)

      <400> 76
 aaggatcctt aattaaatta atcccccctc cccgagtgga agccgccgcc gcgctcgcag     60

 ctcgcaggcg ccgcgtagcc gtcgccaccg ccgccagccc gtgcgccctc ggcgcgtacc    120

 cgccgcgctc ccatccccgc cgccggccag gggcgcgctc ggccgccccg gacagtgtcc    180

 cgctgcggct ccgcggcg  atg gcc acc aag atc gac aaa gag gct tgc cgg     231
                      Met Ala Thr Lys Ile Asp Lys Glu Ala Cys Arg
                        1               5                  10

 gcg gcg tac aac ctg gtg cgc gac gac ggc tcg gcc gtc atc tgg gtg      279
 Ala Ala Tyr Asn Leu Val Arg Asp Asp Gly Ser Ala Val Ile Trp Val
              15                  20                  25

 act ttt aaa tat gac ggc tcc acc atc gtc ccc ggc gag cag gga gcg      327
 Thr Phe Lys Tyr Asp Gly Ser Thr Ile Val Pro Gly Glu Gln Gly Ala
          30                  35                  40

 gag tac cag cac ttc atc cag cag tgc aca gat gac gtc cgg ttg ttt      375
 Glu Tyr Gln His Phe Ile Gln Gln Cys Thr Asp Asp Val Arg Leu Phe
      45                  50                  55

 gcc ttc gtg cgc ttc acc acc ggg gat gcc atg agc aag agg tcc aag      423
 Ala Phe Val Arg Phe Thr Thr Gly Asp Ala Met Ser Lys Arg Ser Lys
  60                  65                  70                  75

 ttt gcc ctc atc acg tgg atc ggt gag aac gtc agc ggg ctg cag cgc      471
 Phe Ala Leu Ile Thr Trp Ile Gly Glu Asn Val Ser Gly Leu Gln Arg
                  80                  85                  90

 gcc aaa acc ggg acg gac aag acc ctg gtg aag gag gtc gta cag aat      519
 Ala Lys Thr Gly Thr Asp Lys Thr Leu Val Lys Glu Val Val Gln Asn
              95                 100                 105

 ttc gct aag gag ttt gtg atc agt gat cgg aag gag ctg gag gaa gat      567
 Phe Ala Lys Glu Phe Val Ile Ser Asp Arg Lys Glu Leu Glu Glu Asp
         110                 115                 120

 ttc atc aag agc gag ctg aag aag gcg ggg gga gcc aat tac gac gcc      615
 Phe Ile Lys Ser Glu Leu Lys Lys Ala Gly Gly Ala Asn Tyr Asp Ala
     125                 130                 135

 cag acg gag taacccc agcccccgcc acaccacccc ttgccaaagt catctgcctg      671
 Gln Thr Glu 
 140

 ctccccgggg gagaggaccg ccggcctcag ctactagccc accagcccac cagggagaag    731

 agaagccatg agaggcagcg cccgccaccc tgtgtccaca gcccccacct tcccgcttcc    791

 cttagaaccc tgccgtgtcc tatctcatga cgctcatgga acctctttct ttgatcttct    851

 ttttcttttc tccccctctt ttttgttcta aagaaaagtc attttgatgc aaggtcctgc    911

 ctgccatcag atccgaggtg cctcctgcag tgaccccttt tcctggcatt tctcttccac    971

 gcgacgaggt ctgcctagtg agatctgcat gacctcacgt tgctttccag agcccgggcc   1031

 tattttgcca tctcagtttt cctggaccct gcttcctgtg taccactgag gggcagctgg   1091

 gccaggagct gtgcccggtg cctgcagcct tcataagcac acacgtccat tccctactaa   1151

 ggcccagacc tcctggtatc tgccccgggc tccctcatcc cacctccatc cggagttgcc   1211

 taagatgcat gtccagcata ggcaggattg ctcggtggtg agaaggttag gtccggctca   1271

 gactgaataa gaagagataa aatttgcctt aaaacttacc tggcagtggc tttgctgcac   1331

 ggtctgaaac cacctgttcc caccctcttg accgaaattt ccttgtgaca cagagaaggg   1391

 caaaggtctg agcccagagt tgacggaggg agtatttcag ggttcacttc aggggctccc   1451

 aaagcgacaa gatcgttagg gagagaggcc cagggtgggg actgggaatt taaggagagc   1511

 tgggaacgga tcccttaggt tcaggaagct tctgtgcaag ctgcgaggat ggcttgggcc   1571

 gaagggttgc tctgcccgcc gcgctagctg tgagctgagc aaagccctgg gctcacagca   1631

 ccccaaaagc ctgtggcttc agtcctgcgt ctgcaccaca caatcaaaag gatcgttttg   1691

 ttttgttttt aaagaaaggt gagattggct tggttcttca tgagcacatt tgatatagct   1751

 ctttttctgt ttttccttgc tcatttcgtt ttggggaaga aatctgtact gtattgggat   1811

 tgtaaagaac atctctgcac tcagacagtt tacagaaata aatgtttttt ttgtttttca   1871

 gaaaaaaaaa aaa                                                      1884




      <210> 77
      <211> 2233
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (48)..(1373)

      <400> 77
 ctttgtaacc ccgttccggc caagccgctt cagcggggga cgtagcc  atg aag gaa      56
                                                      Met Lys Glu
                                                        1

 gag aag gag cac agg cct aag gag aag cga gta acc ctg tta acc ccc      104
 Glu Lys Glu His Arg Pro Lys Glu Lys Arg Val Thr Leu Leu Thr Pro
       5                  10                  15

 gcc ggg gcc aca ggc agc ggt ggt ggg acc tcg ggg gac agc tcc aag      152
 Ala Gly Ala Thr Gly Ser Gly Gly Gly Thr Ser Gly Asp Ser Ser Lys
  20                  25                  30                  35

 ggg gaa gat aag cag gat cgc aac aag gag aag aaa gaa gcg ctg agc      200
 Gly Glu Asp Lys Gln Asp Arg Asn Lys Glu Lys Lys Glu Ala Leu Ser
                  40                  45                  50

 aag gtg ccc ggt cgg ccg ctg gcc cgg gag agg gcg gga cga gtc cgc      248
 Lys Val Pro Gly Arg Pro Leu Ala Arg Glu Arg Ala Gly Arg Val Arg
              55                  60                  65

 agc gcg ggg agg atg gct ggg aat ggg gct gcc ccc ttt ctt tct cag      296
 Ser Ala Gly Arg Met Ala Gly Asn Gly Ala Ala Pro Phe Leu Ser Gln
          70                  75                  80

 gtt ctc ctt cta tct ctt cgc ctg aat gga agt cgc atc atc ctg gtt      344
 Val Leu Leu Leu Ser Leu Arg Leu Asn Gly Ser Arg Ile Ile Leu Val
      85                  90                  95

 cat cca ttc acc cga aat ggg gag agc ccc tcc cgg cca aat cct ggg      392
 His Pro Phe Thr Arg Asn Gly Glu Ser Pro Ser Arg Pro Asn Pro Gly
 100                 105                 110                 115

 tgg ggt ttg tat cct cat atg tat gcc aga gca tac atc aac ttt aaa      440
 Trp Gly Leu Tyr Pro His Met Tyr Ala Arg Ala Tyr Ile Asn Phe Lys
                 120                 125                 130

 aac caa gag gac att att ttg ttc agg gat cgc ttt gat ggt tat gta      488
 Asn Gln Glu Asp Ile Ile Leu Phe Arg Asp Arg Phe Asp Gly Tyr Val
             135                 140                 145

 ttc ctt gac aat aaa gct aaa aag aca acc cca ctt ttg agc ttc ctg      536
 Phe Leu Asp Asn Lys Ala Lys Lys Thr Thr Pro Leu Leu Ser Phe Leu
         150                 155                 160

 aaa aac aag cag aga atg aga gaa gaa aag aga gaa gaa agg agg agg      584
 Lys Asn Lys Gln Arg Met Arg Glu Glu Lys Arg Glu Glu Arg Arg Arg
     165                 170                 175

 aga gaa ata gaa aga aaa aga caa aga gaa gaa gag agg agg aaa tgg      632
 Arg Glu Ile Glu Arg Lys Arg Gln Arg Glu Glu Glu Arg Arg Lys Trp
 180                 185                 190                 195

 aaa gaa gaa gag aaa cga aaa agg aaa gat ata gaa aag cta aag aag      680
 Lys Glu Glu Glu Lys Arg Lys Arg Lys Asp Ile Glu Lys Leu Lys Lys
                 200                 205                 210

 ata gac aga att cca gaa agg gac aaa tta aag gat gaa cca aag att      728
 Ile Asp Arg Ile Pro Glu Arg Asp Lys Leu Lys Asp Glu Pro Lys Ile
             215                 220                 225

 aag gta cac agg ttt ctg tta caa gct gtg aat cag aaa aat ctg ctc      776
 Lys Val His Arg Phe Leu Leu Gln Ala Val Asn Gln Lys Asn Leu Leu
         230                 235                 240

 aag aag cca gaa aaa gga gat gaa aaa gaa ttg gac aaa aga gaa aaa      824
 Lys Lys Pro Glu Lys Gly Asp Glu Lys Glu Leu Asp Lys Arg Glu Lys
     245                 250                 255

 gcc aag aaa ttg gac aaa gag aat ctc agt gat gaa aga gcc agt ggg      872
 Ala Lys Lys Leu Asp Lys Glu Asn Leu Ser Asp Glu Arg Ala Ser Gly
 260                 265                 270                 275

 caa agt tgt aca ttg ccc aag cgt tct gat agc gaa ctt aaa gat gaa      920
 Gln Ser Cys Thr Leu Pro Lys Arg Ser Asp Ser Glu Leu Lys Asp Glu
                 280                 285                 290

 aaa cca aag aga cct gaa gat gag agc ggc aga gac tat agg gag agg      968
 Lys Pro Lys Arg Pro Glu Asp Glu Ser Gly Arg Asp Tyr Arg Glu Arg
             295                 300                 305

 gaa cgg gaa tat gaa cga gat cag gag cgc ata ctt cga gaa aga gag     1016
 Glu Arg Glu Tyr Glu Arg Asp Gln Glu Arg Ile Leu Arg Glu Arg Glu
         310                 315                 320

 agg ctg aag cgg caa gaa gaa gag cgc cgt agg cag aag gag cgc tat     1064
 Arg Leu Lys Arg Gln Glu Glu Glu Arg Arg Arg Gln Lys Glu Arg Tyr
     325                 330                 335

 gag aaa gag aag act ttt aag aga aaa gaa gaa gaa atg aaa aaa gag     1112
 Glu Lys Glu Lys Thr Phe Lys Arg Lys Glu Glu Glu Met Lys Lys Glu
 340                 345                 350                 355

 aaa gac aca ctt cgg gat aaa gga aag aag gct gaa agt aca gaa tca     1160
 Lys Asp Thr Leu Arg Asp Lys Gly Lys Lys Ala Glu Ser Thr Glu Ser
                 360                 365                 370

 ata ggc agc tca gaa aaa act gaa aag aaa gaa gaa gtg gtc aag aga     1208
 Ile Gly Ser Ser Glu Lys Thr Glu Lys Lys Glu Glu Val Val Lys Arg
             375                 380                 385

 gat cga ata aga aac aag gat cgt cca gcg atg cag ctt tac caa cca     1256
 Asp Arg Ile Arg Asn Lys Asp Arg Pro Ala Met Gln Leu Tyr Gln Pro
         390                 395                 400

 gga gct cga agc cga aat cga ctc tgt ccc cct gat gac agc acc aag     1304
 Gly Ala Arg Ser Arg Asn Arg Leu Cys Pro Pro Asp Asp Ser Thr Lys
     405                 410                 415

 tct gga gat tca gca gca gaa agg aag cag gaa agt ggt att agc cat     1352
 Ser Gly Asp Ser Ala Ala Glu Arg Lys Gln Glu Ser Gly Ile Ser His
 420                 425                 430                 435

 aga aaa gaa gga gga gag gag tg ataagtccag atggccttag gtgtcctgac     1405
 Arg Lys Glu Gly Gly Glu Glu 
                 440

 tgtctaggca gccaaagagc acacgttaag caatccagag gtgccttcag ggcaaagaat   1465

 agagagaaag ggagccgctg tgctggtggg gtacactgca gaggagtaag tcttgtgtca   1525

 aagcaggaat ctgatcagag gttcagaatt ggaagtacaa tttcattgct tttgcaattt   1585

 ctacaaatta attttaaagt gtcagaaaaa ggtgacggca aggacatgca ttgcaatttg   1645

 cagggggaat tgtcaagtga ggacttcatc acatatgaca cgagagaaaa gtaagagctg   1705

 gttctaaaat caaaagctgt tgttcatcct gaattgaatt ttctgaattt gggtggagca   1765

 gagtcgcttt gaagccttgt tccgatctaa ttctattgta ttgttgatga taagtgttga   1825

 cattgggtag tgtagaagca acaagcatgt ccttgtagta caggtacagt gaaggataga   1885

 acacactttc gttgatacaa aaatttaaat agttatgtta cttctgtatc cagtgtccta   1945

 aagttttagg attagtttta gttttttgtt tgcttatatg agcttagcgt aaagaatatt   2005

 tttaaacttc gtgttttgtc atcagcatct tttctattaa gaggtaaaat gtagtccttg   2065

 tttgactctt gacaatccag tgtgtttgat cttaggtctc atgatctgag tgcataccct   2125

 ctccaggaag gaaactgcac cagtgtctat tcctgttaaa tagcaacttt tagtctcagc   2185

 ttgtttcgtt ttgatgtcaa taaatagtaa cagcataaaa aaaaaaaa                2233




      <210> 78
      <211> 1353
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (28)..(855)

      <400> 78
 aaatgttttg tatatagtaa tggactc    atg gat cat cta tgt gtc tgt gaa      51
                                  Met Asp His Leu Cys Val Cys Glu
                                    1               5

 gag gga ggc aac aaa cta tgg tat aag aag cca gga aat ttc cag gga       99
 Glu Gly Gly Asn Lys Leu Trp Tyr Lys Lys Pro Gly Asn Phe Gln Gly
      10                  15                  20

 aca ttg gat gca ttt ttt aaa atc att cga aat gag ggc att aaa tct      147
 Thr Leu Asp Ala Phe Phe Lys Ile Ile Arg Asn Glu Gly Ile Lys Ser
  25                  30                  35                  40

 cta tgg agt ggc ctt cct cct acc cta gtg atg gca gtt cct gcc aca      195
 Leu Trp Ser Gly Leu Pro Pro Thr Leu Val Met Ala Val Pro Ala Thr
                  45                  50                  55

 gtt att tat ttt acc tgc tat gat caa tta agt gct ctt ctg aga tct      243
 Val Ile Tyr Phe Thr Cys Tyr Asp Gln Leu Ser Ala Leu Leu Arg Ser
              60                  65                  70

 aag tta gga gaa aat gaa acc tgc ata cca att gtt gct gga att gta      291
 Lys Leu Gly Glu Asn Glu Thr Cys Ile Pro Ile Val Ala Gly Ile Val
          75                  80                  85

 gcc aga ttt ggt gca gta act gtg ata agt cca cta gaa ttg att aga      339
 Ala Arg Phe Gly Ala Val Thr Val Ile Ser Pro Leu Glu Leu Ile Arg
      90                  95                 100

 acc aag atg cag tcc aag aag ttt tct tac gtg gaa ctg cat cga ttt      387
 Thr Lys Met Gln Ser Lys Lys Phe Ser Tyr Val Glu Leu His Arg Phe
 105                 110                 115                 120

 gtc agc aag aaa gta tct gaa gat ggt tgg att tcc ctt tgg agg ggc      435
 Val Ser Lys Lys Val Ser Glu Asp Gly Trp Ile Ser Leu Trp Arg Gly
                 125                 130                 135

 tgg gct cct act gtt ctt aga gat gta cct ttc tca gca atg tac tgg      483
 Trp Ala Pro Thr Val Leu Arg Asp Val Pro Phe Ser Ala Met Tyr Trp
             140                 145                 150

 tat aac tat gaa att tta aag aag tgg tta tgt gag aaa tct ggt tta      531
 Tyr Asn Tyr Glu Ile Leu Lys Lys Trp Leu Cys Glu Lys Ser Gly Leu
         155                 160                 165

 tat gag cca aca ttt atg atc aac ttt act tca ggg gca ttg tct ggt      579
 Tyr Glu Pro Thr Phe Met Ile Asn Phe Thr Ser Gly Ala Leu Ser Gly
     170                 175                 180

 tct ttt gct gct gtt gca act tta cca ttt gat gta gta aaa aca caa      627
 Ser Phe Ala Ala Val Ala Thr Leu Pro Phe Asp Val Val Lys Thr Gln
 185                 190                 195                 200

 aag cag aca caa ctt tgg aca tat gaa agt cat aaa att tct atg cct      675
 Lys Gln Thr Gln Leu Trp Thr Tyr Glu Ser His Lys Ile Ser Met Pro
                 205                 210                 215

 ttg cat atg tca acc tgg att ata atg aag aac att gtt gct aaa aat      723
 Leu His Met Ser Thr Trp Ile Ile Met Lys Asn Ile Val Ala Lys Asn
             220                 225                 230

 gga ttt tcc gga tta ttt tca ggc cta att cct cgc tta att aaa att      771
 Gly Phe Ser Gly Leu Phe Ser Gly Leu Ile Pro Arg Leu Ile Lys Ile
         235                 240                 245

 gct cct gct tgt gcc att atg atc agt aca tat gaa ttt gga aag gct      819
 Ala Pro Ala Cys Ala Ile Met Ile Ser Thr Tyr Glu Phe Gly Lys Ala
     250                 255                 260

 ttt ttc cag aaa caa aat gtt cga agg cag caa tac tagt gatgctgttt      869
 Phe Phe Gln Lys Gln Asn Val Arg Arg Gln Gln Tyr 
 265                 270                 275

 caacttgaaa caacaactat agccaaagaa gatggagact cttaggcaag aatgtttttc    929

 accattattc tctcacaatg attttatgtc tttctttcct ataatttaaa taaataattt    989

 cagctctacc tctaaatcat aattttaaaa taaattttat cttatttttg gtgatattga   1049

 aaaagatatt ctagaaatca ccaccattga gcattcttgt aaaaatagat tactccttag   1109

 catcaaaagc agtctcttga aagtttaata ttatatgttt cagtgtaaca taatcttact   1169

 gggagtgtgt tgaatacacc agaacttttt gaattgtgtg ctgaatgatg tacatagtct   1229

 agaagaaaaa agcccaagtc ttgtgcacat ttaaatcgtg tacataagta tttccgtatt   1289

 tcagtaaagt agataaagca ctcgttaaat agcattgttt acatcgacca aaaaaaaaaa   1349

 aaaa                                                                1353




      <210> 79
      <211> 3908
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (48)..(2972)

      <400> 79
 ggaatctctg cacgggcctt ggaaaacgac tgtcttcttc tgccaaa  atg tca gga      56
                                                      Met Ser Gly
                                                        1

 att gga aat aaa aga gca gct gga gaa cct gtc acc tcc atg cct cct      104
 Ile Gly Asn Lys Arg Ala Ala Gly Glu Pro Val Thr Ser Met Pro Pro
       5                  10                  15

 gag aag aag gca gct gtt gaa gat tca ggg acc aca gtg gaa aca att      152
 Glu Lys Lys Ala Ala Val Glu Asp Ser Gly Thr Thr Val Glu Thr Ile
  20                  25                  30                  35

 aag cta gga ggt gtc tct tca acg gag gaa cta gac att aga aca ctg      200
 Lys Leu Gly Gly Val Ser Ser Thr Glu Glu Leu Asp Ile Arg Thr Leu
                  40                  45                  50

 caa acc aaa aat cgc aag ctg gca gaa atg ttg gat cag cgg cag gcc      248
 Gln Thr Lys Asn Arg Lys Leu Ala Glu Met Leu Asp Gln Arg Gln Ala
              55                  60                  65

 att gaa gat gaa ctt cgt gag cac att gaa aaa ctg gaa cga cga cag      296
 Ile Glu Asp Glu Leu Arg Glu His Ile Glu Lys Leu Glu Arg Arg Gln
          70                  75                  80

 gcc act gat gat gcc tca cta ttg att gtc aac cga tac tgg agt cag      344
 Ala Thr Asp Asp Ala Ser Leu Leu Ile Val Asn Arg Tyr Trp Ser Gln
      85                  90                  95

 ttt gat gaa aac atc cgt atc atc ctt aaa cgt tat gat ctg gag cag      392
 Phe Asp Glu Asn Ile Arg Ile Ile Leu Lys Arg Tyr Asp Leu Glu Gln
 100                 105                 110                 115

 ggc ttg gga gac cta ctc aca gaa cga aaa gcc ctt gtt gtg cct gaa      440
 Gly Leu Gly Asp Leu Leu Thr Glu Arg Lys Ala Leu Val Val Pro Glu
                 120                 125                 130

 cca gaa cca gac tct gat agc aat cag gag cgt aaa gat gac cga gag      488
 Pro Glu Pro Asp Ser Asp Ser Asn Gln Glu Arg Lys Asp Asp Arg Glu
             135                 140                 145

 aga ggg gaa ggg caa gag cca gct ttc tct ttc ctt gct act ttg gcc      536
 Arg Gly Glu Gly Gln Glu Pro Ala Phe Ser Phe Leu Ala Thr Leu Ala
         150                 155                 160

 agc agt tcc agt gaa gag atg gag tct cag ctg cag gaa cgt gtg gag      584
 Ser Ser Ser Ser Glu Glu Met Glu Ser Gln Leu Gln Glu Arg Val Glu
     165                 170                 175

 tct tcc cgc cga gcc gtg tcc cag att gtg act gtt tat gat aaa ttg      632
 Ser Ser Arg Arg Ala Val Ser Gln Ile Val Thr Val Tyr Asp Lys Leu
 180                 185                 190                 195

 caa gaa aaa gtg gag ctc tta tcc cgg aag cta aac agt gga gat aat      680
 Gln Glu Lys Val Glu Leu Leu Ser Arg Lys Leu Asn Ser Gly Asp Asn
                 200                 205                 210

 ctg ata gtg gag gaa gca gtg cag gag ctg aac tct ttc ctc gca cag      728
 Leu Ile Val Glu Glu Ala Val Gln Glu Leu Asn Ser Phe Leu Ala Gln
             215                 220                 225

 gag aat atg agg cta cag gaa ttg aca gat ctt ctt cag gaa aag cat      776
 Glu Asn Met Arg Leu Gln Glu Leu Thr Asp Leu Leu Gln Glu Lys His
         230                 235                 240

 cgc acc atg tct cag gag ttc tcc aag ttg cag agt aaa gtg gag aca      824
 Arg Thr Met Ser Gln Glu Phe Ser Lys Leu Gln Ser Lys Val Glu Thr
     245                 250                 255

 gcc gaa tca cga gtg tct gtc ctg gag tcc atg att gat gac ctg cag      872
 Ala Glu Ser Arg Val Ser Val Leu Glu Ser Met Ile Asp Asp Leu Gln
 260                 265                 270                 275

 tgg gat att gac aaa att cga aag agg gaa cag cga ctc aac cga cac      920
 Trp Asp Ile Asp Lys Ile Arg Lys Arg Glu Gln Arg Leu Asn Arg His
                 280                 285                 290

 tta gca gaa gtc cta gaa cgg gtg aat tcc aaa ggt tat aag gtg tat      968
 Leu Ala Glu Val Leu Glu Arg Val Asn Ser Lys Gly Tyr Lys Val Tyr
             295                 300                 305

 gga gcg ggg agc agt ctg tat ggc ggc aca atc act atc aat gct cgg     1016
 Gly Ala Gly Ser Ser Leu Tyr Gly Gly Thr Ile Thr Ile Asn Ala Arg
         310                 315                 320

 aag ttt gag gaa atg aat gca gag ctt gag gag aac aaa gag ttg gct     1064
 Lys Phe Glu Glu Met Asn Ala Glu Leu Glu Glu Asn Lys Glu Leu Ala
     325                 330                 335

 cag aac cgt ctc tgt gag ctg gag aaa ctt cgg caa gac ttt gag gag     1112
 Gln Asn Arg Leu Cys Glu Leu Glu Lys Leu Arg Gln Asp Phe Glu Glu
 340                 345                 350                 355

 gtc act aca caa aat gaa aag ctg aag gtg gaa ttg cgg agt gca gtg     1160
 Val Thr Thr Gln Asn Glu Lys Leu Lys Val Glu Leu Arg Ser Ala Val
                 360                 365                 370

 gag caa gtc gtt aag gaa act cca gaa tat cgc tgc atg cag tca cag     1208
 Glu Gln Val Val Lys Glu Thr Pro Glu Tyr Arg Cys Met Gln Ser Gln
             375                 380                 385

 ttc tcc gtc ttg tat aat gag agc cta cag ttg aaa gca cac ttg gat     1256
 Phe Ser Val Leu Tyr Asn Glu Ser Leu Gln Leu Lys Ala His Leu Asp
         390                 395                 400

 gag gct cgg acc ctg ctt cat ggc acc aga gga acc cac cag cac cag     1304
 Glu Ala Arg Thr Leu Leu His Gly Thr Arg Gly Thr His Gln His Gln
     405                 410                 415

 gtt gag ctt att gag cga gat gag gtt agt ctt cat aag aag ctg agg     1352
 Val Glu Leu Ile Glu Arg Asp Glu Val Ser Leu His Lys Lys Leu Arg
 420                 425                 430                 435

 act gaa gta att cag cta gaa gat aca ttg gcc cag gtc cgc aag gag     1400
 Thr Glu Val Ile Gln Leu Glu Asp Thr Leu Ala Gln Val Arg Lys Glu
                 440                 445                 450

 tat gaa atg ctg agg ata gaa ttt gag cag acc ctt gct gcc aat gaa     1448
 Tyr Glu Met Leu Arg Ile Glu Phe Glu Gln Thr Leu Ala Ala Asn Glu
             455                 460                 465

 caa gca ggc cct ata aac agg gag atg cgc cac ctc atc agt agc ctc     1496
 Gln Ala Gly Pro Ile Asn Arg Glu Met Arg His Leu Ile Ser Ser Leu
         470                 475                 480

 cag aat cac aat cac cag ctg aaa ggg gag gtc ctg aga tat aag cgg     1544
 Gln Asn His Asn His Gln Leu Lys Gly Glu Val Leu Arg Tyr Lys Arg
     485                 490                 495

 aaa ttg aga gaa gcc cag tct gac ctg aac aag aca cgc ctg cgt agt     1592
 Lys Leu Arg Glu Ala Gln Ser Asp Leu Asn Lys Thr Arg Leu Arg Ser
 500                 505                 510                 515

 ggt agt gcc ctc ctg cag tcc cag tct agt act gag gac ccg aag gat     1640
 Gly Ser Ala Leu Leu Gln Ser Gln Ser Ser Thr Glu Asp Pro Lys Asp
                 520                 525                 530

 gag cct gcg gag cta aaa cca gat tct gag gac tta tcc tcc cag tcc     1688
 Glu Pro Ala Glu Leu Lys Pro Asp Ser Glu Asp Leu Ser Ser Gln Ser
             535                 540                 545

 tca gct tca aag gca tct cag gag gat gcc aat gaa atc aag tct aaa     1736
 Ser Ala Ser Lys Ala Ser Gln Glu Asp Ala Asn Glu Ile Lys Ser Lys
         550                 555                 560

 cgg gat gaa gaa gaa cga gaa cga gaa agg agg gag aag gag agg gaa     1784
 Arg Asp Glu Glu Glu Arg Glu Arg Glu Arg Arg Glu Lys Glu Arg Glu
     565                 570                 575

 cga gaa aga gaa cgg gag aag gag aag gag aga gaa cga gag aag cag     1832
 Arg Glu Arg Glu Arg Glu Lys Glu Lys Glu Arg Glu Arg Glu Lys Gln
 580                 585                 590                 595

 aag cta aaa gag tca gaa aaa gag aga gat tct gct aag gat aaa gag     1880
 Lys Leu Lys Glu Ser Glu Lys Glu Arg Asp Ser Ala Lys Asp Lys Glu
                 600                 605                 610

 aaa ggc aaa cat gat gat gga cgg aaa aag gaa gca gaa att atc aaa     1928
 Lys Gly Lys His Asp Asp Gly Arg Lys Lys Glu Ala Glu Ile Ile Lys
             615                 620                 625

 caa ttg aag att gaa ctc aag aag gca cag gag agc caa aag gag atg     1976
 Gln Leu Lys Ile Glu Leu Lys Lys Ala Gln Glu Ser Gln Lys Glu Met
         630                 635                 640

 aaa cta ttg ctg gat atg tac cgt tct gcc cca aag gaa cag aga gac     2024
 Lys Leu Leu Leu Asp Met Tyr Arg Ser Ala Pro Lys Glu Gln Arg Asp
     645                 650                 655

 aaa gtt cag ctg atg gca gct gag aag aag tct aag gca gag ttg gaa     2072
 Lys Val Gln Leu Met Ala Ala Glu Lys Lys Ser Lys Ala Glu Leu Glu
 660                 665                 670                 675

 gat cta agg caa aga ctc aag gat ctg gaa gat aaa gag aag aaa gag     2120
 Asp Leu Arg Gln Arg Leu Lys Asp Leu Glu Asp Lys Glu Lys Lys Glu
                 680                 685                 690

 aac aag aaa atg gct gat gag gat gcc ttg agg aag atc cgg gca gtg     2168
 Asn Lys Lys Met Ala Asp Glu Asp Ala Leu Arg Lys Ile Arg Ala Val
             695                 700                 705

 gag gag cag ata gaa tac cta cag aag aag cta gcc atg gcc aag cag     2216
 Glu Glu Gln Ile Glu Tyr Leu Gln Lys Lys Leu Ala Met Ala Lys Gln
         710                 715                 720

 gaa gaa gaa gca ctc ctc tct gaa atg gat gtc aca ggc cag gcc ttt     2264
 Glu Glu Glu Ala Leu Leu Ser Glu Met Asp Val Thr Gly Gln Ala Phe
     725                 730                 735

 gaa gac atg cag gag caa aat atc cgt ttg atg cag caa ttg cgg gag     2312
 Glu Asp Met Gln Glu Gln Asn Ile Arg Leu Met Gln Gln Leu Arg Glu
 740                 745                 750                 755

 aag gat gat gca aat ttc aag ctc atg tca gag cgt atc aag tcc aat     2360
 Lys Asp Asp Ala Asn Phe Lys Leu Met Ser Glu Arg Ile Lys Ser Asn
                 760                 765                 770

 cag atc cat aag ttg ctt aaa gaa gag aag gag gag ctg gca gac cag     2408
 Gln Ile His Lys Leu Leu Lys Glu Glu Lys Glu Glu Leu Ala Asp Gln
             775                 780                 785

 gtg ttg act ctg aag act cag gtt gat gcc cag cta cag gta gta agg     2456
 Val Leu Thr Leu Lys Thr Gln Val Asp Ala Gln Leu Gln Val Val Arg
         790                 795                 800

 aaa ctg gaa gag aag gag cat ctg tta cag agc aac att ggc aca ggg     2504
 Lys Leu Glu Glu Lys Glu His Leu Leu Gln Ser Asn Ile Gly Thr Gly
     805                 810                 815

 gag aaa gag ctg ggt ctt agg acc caa gcc tta gag atg aat aaa cgc     2552
 Glu Lys Glu Leu Gly Leu Arg Thr Gln Ala Leu Glu Met Asn Lys Arg
 820                 825                 830                 835

 aag gca atg gag gca gcc cag ctt gca gat gac ctc aaa gca caa ctg     2600
 Lys Ala Met Glu Ala Ala Gln Leu Ala Asp Asp Leu Lys Ala Gln Leu
                 840                 845                 850

 gag ttg gct cag aag aag cta cat gat ttt cag gat gag atc gtg gag     2648
 Glu Leu Ala Gln Lys Lys Leu His Asp Phe Gln Asp Glu Ile Val Glu
             855                 860                 865

 aac agt gtt acc aaa gaa aag gac atg ttc aat ttc aaa cga gcc cag     2696
 Asn Ser Val Thr Lys Glu Lys Asp Met Phe Asn Phe Lys Arg Ala Gln
         870                 875                 880

 gag gac atc tct aga ctt cgc agg aag ctg gag acc aca aag aaa cca     2744
 Glu Asp Ile Ser Arg Leu Arg Arg Lys Leu Glu Thr Thr Lys Lys Pro
     885                 890                 895

 gac aat gta ccc aag tgt gat gag att ctg atg gaa gag att aag gat     2792
 Asp Asn Val Pro Lys Cys Asp Glu Ile Leu Met Glu Glu Ile Lys Asp
 900                 905                 910                 915

 tac aag gca cgc ttg acc tgt ccg tgc tgt aac atg cgt aaa aag gat     2840
 Tyr Lys Ala Arg Leu Thr Cys Pro Cys Cys Asn Met Arg Lys Lys Asp
                 920                 925                 930

 gct gtt ctt act aag tgt ttt cat gtc ttc tgc ttt gag tgt gtg aag     2888
 Ala Val Leu Thr Lys Cys Phe His Val Phe Cys Phe Glu Cys Val Lys
             935                 940                 945

 aca cgc tat gac acc cgc cag cgc aaa tgt ccc aag tgt aat gct gct     2936
 Thr Arg Tyr Asp Thr Arg Gln Arg Lys Cys Pro Lys Cys Asn Ala Ala
         950                 955                 960

 ttt ggt gcc aat gat ttt cat cgc atc tac att ggt tgat ctaagtcaag     2986
 Phe Gly Ala Asn Asp Phe His Arg Ile Tyr Ile Gly 
     965                 970                 975

 agaagaagag gagctggcta gtcaggaact tattcattaa ccaccaaacc tctacctctt   3046

 ctctccttga ctgtcacctg taggacagtt tatcagtcaa ctacctttcc tccagacttt   3106

 acttccaggc tctcctcttc agtagctgga tgactttagc agaaaggact ggtaaataca   3166

 agccttgggt ttcagaatga attagaaaca aataactctt actgtcttcc ctcccagctt   3226

 tgtttatttt gtgcttttag acttttcagt gttttctttt tccagcccac tgtataaact   3286

 tggattgtcc attcctcctg aagaaatcaa gttggtattt ttgatgtgga aaagggaaca   3346

 aaagtggaaa catggctact tttggggagt gatattttaa aaaataagtt gtctatgggc   3406

 acaaagtttt cttcatttgt gtagcaaact tcttgtgaat gtggattaca aaatggtata   3466

 attgtgctac tctcccctgg gtggtttgca gccctaatga aattatgtct aggatgattc   3526

 agtctatttc ccatttacta gcagagtaac ttgttaagat cagctggctt tcttgttaaa   3586

 gttatttaag ttttgaatgc tctactactt caagtcttta aatttcttga gactagaata   3646

 attttaaata atatgaccct ttgtcttcta atgaaataaa gattgaagag gttgagtcag   3706

 gactgagctg gtgaagaaat cttgtgggta ttctggaaat ttgatacgga gagaacttgg   3766

 tgagctatga attactctca gtctcctttt tacagggttg ttgtgatccc tcttttccag   3826

 aaaattctgt ggaatgtttc tgtaggactt tgttctccac aagcttgaat taaagcagga   3886

 ttcagtttgc aaaaaaaaaa aa                                            3908




      <210> 80
      <211> 1702
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (347)..(619)

      <400> 80
 cctgttcacg gattttcaag caagtttcta gagcatgtgt acgtccttcc cattcagatt     60

 ttttatgagc caccattatg tcaatctgtt tcatgagctc ctgtagttct gcttcacaag    120

 atgtcaaaaa tcccccacca tgccctcgat tttgtattcc ttctaacaaa gcctccatca    180

 ccaaatcccc tttgttttgg caaccacatc cgggaatccg aggaaagcga gtgcagacac    240

 gtgatgcggg ggagggcggg gcgtggcagg agcaagcgtc tgccgcggtg gccgggtgcc    300

 ggtaagggtt tccagcgccc ccggcctagg ttttggaggc gcggga   atg cgt tcg     355
                                                      Met Arg Ser
                                                        1

 ttg ctc agt gtc gga ctt ccc cct att ccc atc ggc cga ggc tgt cac      403
 Leu Leu Ser Val Gly Leu Pro Pro Ile Pro Ile Gly Arg Gly Cys His
       5                  10                  15

 ttt acg ctc ata acc gtt ttt ctt tac tgc act cgt gtc ggg agg aaa      451
 Phe Thr Leu Ile Thr Val Phe Leu Tyr Cys Thr Arg Val Gly Arg Lys
  20                  25                  30                  35

 ggg act tgc gtg gca ccc cca gac ctc ccc gtc tcc gct tcc acg ttt      499
 Gly Thr Cys Val Ala Pro Pro Asp Leu Pro Val Ser Ala Ser Thr Phe
                  40                  45                  50

 ggt aca tcc tgc ctg agg cag gaa gcc gca gct gag gga cgg cct gtc      547
 Gly Thr Ser Cys Leu Arg Gln Glu Ala Ala Ala Glu Gly Arg Pro Val
              55                  60                  65

 gta cga ttt gac aag atc aaa gct gca gga aaa tgg aca gtg agg ttc      595
 Val Arg Phe Asp Lys Ile Lys Ala Ala Gly Lys Trp Thr Val Arg Phe
          70                  75                  80

 aga gag gtg gaa gga tct tgg att tgattgatga tgcttggcga gaagacaagc     649
 Arg Glu Val Glu Gly Ser Trp Ile 
      85                  90

 tgccttatga ggatgtcgca ataccactga atgagcttcc tgaacctgaa caagacaatg    709

 gtggcaccac agaatctgtc aaagaacaag aaatgaagtg gacagactta gccttacagt    769

 acctccatgg gaatgttccc cccattggaa actgacgctt ggctcctttc ttgtggatgg    829

 attttctcaa agtacacaga taaagcatgg tttgtttcag tctccaaatt caaacctttg    889

 agtaataaat cagcactcaa aaatgtacac ccatttagtt tgtggtagca aagtgcaatg    949

 ccgaaattga atgagaaact gagatttctc agtaatggtg aatatttcgc tctttaaacc   1009

 taaaactctt cattgagtag cttatatttg aacatgattg gttaaacatt tgcctctacc   1069

 tctgattttg ctttgctgtc aaagtttaac accttccaac tacttatgtg tgtcctgtaa   1129

 cacaggtgat tgaacgtatg agagggaaag gcaaagaaaa aggaagccag acactaggag   1189

 aattattaac ttctcatact tccccacatt gagaagcatt cggagtgtat ttagcctgta   1249

 gatgttgtga tatgcaaata tcccattccc tggttactgg cattcctaag attcttcatg   1309

 gtattttcaa actttggata aatttacaga ttagaaagat atctgacagt taatctctgt   1369

 tctccttaca aattcctttt gtgctgctgg aaaggatctt tggctaggtg gatgactagt   1429

 tttattcaaa gccttttctc aaagcccttt cagttacaac caccccacta tggaatcagt   1489

 atttagttat acatttgtat aagaacctgt attttgaaaa acacattcat gtatatttat   1549

 tcctggaatt atttgcctgt taaacagtgt ctttcatgtt ctctccccag attgtaaact   1609

 ctgtaagaag ctgcttgtat ctgtatccct tgttgaaact ctgaaaacac tgaataacta   1669

 aaatctcttc tcatcctttt aaaaaaaaaa aaa                                1702




      <210> 81
      <211> 670
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (48)..(449)

      <400> 81
 cttgcgcgga gaactcagcg ctgagattgt ctaaagcccc aggaaaa  atg gtg gaa      56
                                                      Met Val Glu
                                                        1

 aat tca ccg tcg cca ttg cca gaa aga gcg att tat ggc ttt gtt ctt      104
 Asn Ser Pro Ser Pro Leu Pro Glu Arg Ala Ile Tyr Gly Phe Val Leu
       5                  10                  15

 ttc tta agc tcc caa ttt ggc ttc ata ctt tac ctc gtg tgg gcc ttt      152
 Phe Leu Ser Ser Gln Phe Gly Phe Ile Leu Tyr Leu Val Trp Ala Phe
  20                  25                  30                  35

 att cct gaa tct tgg cta aac tct tta ggt tta acc tat tgg cct caa      200
 Ile Pro Glu Ser Trp Leu Asn Ser Leu Gly Leu Thr Tyr Trp Pro Gln
                  40                  45                  50

 aaa tat tgg gca gtt gca tta cct gtc tac ctc ctt att gct ata gta      248
 Lys Tyr Trp Ala Val Ala Leu Pro Val Tyr Leu Leu Ile Ala Ile Val
              55                  60                  65

 att ggc tac gtg ctc ttg ttt ggg att aac atg atg agt acc tct cca      296
 Ile Gly Tyr Val Leu Leu Phe Gly Ile Asn Met Met Ser Thr Ser Pro
          70                  75                  80

 ctc gac tcc atc cat aca atc aca gat aac tat gca aaa aat caa cag      344
 Leu Asp Ser Ile His Thr Ile Thr Asp Asn Tyr Ala Lys Asn Gln Gln
      85                  90                  95

 cag aag aaa tac caa gag gag gcc att cca gcc tta aga gat att tct      392
 Gln Lys Lys Tyr Gln Glu Glu Ala Ile Pro Ala Leu Arg Asp Ile Ser
 100                 105                 110                 115

 att agt gaa gta aac caa atg ttc ttt ctt gca gcc aaa gaa ctt tac      440
 Ile Ser Glu Val Asn Gln Met Phe Phe Leu Ala Ala Lys Glu Leu Tyr
                 120                 125                 130

 acc aaa aac tgaactg tgtgtaacca tagtaacacc aagcacgtat ttatttataa      496
 Thr Lys Asn 


 gtttttgcca ttataatttt gaccataaat taatttgacc atctctctta ttaatagaga    556

 agtaaaaaat gtaacttgac cttctcttag attatgttca atgaatattg taaatgttca    616

 agtattgtta atgaatagaa taaatacaat attgcattcc cataaaaaaa aaaa          670




      <210> 82
      <211> 1584
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (176)..(1534)

      <400> 82
 ggcagttcct cccggtgtcg gaggccgatt cgccgtgtgg cgggttcggg tcccgcctcc     60

 tgactctggc ctctagtccc tgagtcccgg gcgggctgca ttcgtcgggg aaacctctcc    120

 tcgaccaggg gcacctctac tcgaccaggg gcgacggcgt actttgggct tcatc atg     178
                                                              Met
                                                                1

 gag gac tac ctg cag ggt tgt cga gct gct ctg cag gag tcc cga cct      226
 Glu Asp Tyr Leu Gln Gly Cys Arg Ala Ala Leu Gln Glu Ser Arg Pro
               5                  10                  15

 cta cat gtt gtg ctg gga aat gaa gcc tgt gat ttg gac tcc aca gtg      274
 Leu His Val Val Leu Gly Asn Glu Ala Cys Asp Leu Asp Ser Thr Val
          20                  25                  30

 tct gct ctt gcc ctg gct ttt tac cta gca aag aca act gag gct gag      322
 Ser Ala Leu Ala Leu Ala Phe Tyr Leu Ala Lys Thr Thr Glu Ala Glu
      35                  40                  45

 gaa gtc ttt gtg cca gtt tta aat ata aaa cgt tct gaa cta cct ctg      370
 Glu Val Phe Val Pro Val Leu Asn Ile Lys Arg Ser Glu Leu Pro Leu
  50                  55                  60                  65

 cga ggt gac att gtc ttc ttt ctt cag aag gtt cat att cca gag agt      418
 Arg Gly Asp Ile Val Phe Phe Leu Gln Lys Val His Ile Pro Glu Ser
                  70                  75                  80

 atc ttg att ttt cgg gat gag att gac ctc cat gca tta tac cag gct      466
 Ile Leu Ile Phe Arg Asp Glu Ile Asp Leu His Ala Leu Tyr Gln Ala
              85                  90                  95

 ggc caa ctc acc ctc atc ctt gtc gac cat cat atc tta tcc aaa agt      514
 Gly Gln Leu Thr Leu Ile Leu Val Asp His His Ile Leu Ser Lys Ser
         100                 105                 110

 gac aca gcc cta gag gag gca gta gca gag gtg cta gac cat cga ccc      562
 Asp Thr Ala Leu Glu Glu Ala Val Ala Glu Val Leu Asp His Arg Pro
     115                 120                 125

 atc gag ccg aaa cac tgc cct ccc tgc cat gtt tca gtt gag ctg gtg      610
 Ile Glu Pro Lys His Cys Pro Pro Cys His Val Ser Val Glu Leu Val
 130                 135                 140                 145

 ggg tcc tgt gct acc ctg gtg acc gag aga atc ctg cag ggg gca cca      658
 Gly Ser Cys Ala Thr Leu Val Thr Glu Arg Ile Leu Gln Gly Ala Pro
                 150                 155                 160

 gag atc ttg gac agg caa act gca gcc ctt ctg cat gga acc atc atc      706
 Glu Ile Leu Asp Arg Gln Thr Ala Ala Leu Leu His Gly Thr Ile Ile
             165                 170                 175

 ctg gac tgt gtc aac atg gac ctt aaa att gga aag gca acc cca aag      754
 Leu Asp Cys Val Asn Met Asp Leu Lys Ile Gly Lys Ala Thr Pro Lys
         180                 185                 190

 gac agc aaa tat gtg gag aaa cta gag gcc ctt ttc cca gac cta ccc      802
 Asp Ser Lys Tyr Val Glu Lys Leu Glu Ala Leu Phe Pro Asp Leu Pro
     195                 200                 205

 aag aga aat gat ata ttt gat tcc cta caa aag gca aag ttt gat gta      850
 Lys Arg Asn Asp Ile Phe Asp Ser Leu Gln Lys Ala Lys Phe Asp Val
 210                 215                 220                 225

 tca gga ctg acc act gag cag atg ctg aga aaa gac cag aag act atc      898
 Ser Gly Leu Thr Thr Glu Gln Met Leu Arg Lys Asp Gln Lys Thr Ile
                 230                 235                 240

 tat aga caa ggc gtc aag gtg gcc att agt gca ata tat atg gat ttg      946
 Tyr Arg Gln Gly Val Lys Val Ala Ile Ser Ala Ile Tyr Met Asp Leu
             245                 250                 255

 gag gcc ttt ctg cag agg tct aac ctc ctt gca gat ctc cat gct ttc      994
 Glu Ala Phe Leu Gln Arg Ser Asn Leu Leu Ala Asp Leu His Ala Phe
         260                 265                 270

 tgc cag gct cac agc tat gat gtc ctg gtt gcc atg act atc ttt ttc     1042
 Cys Gln Ala His Ser Tyr Asp Val Leu Val Ala Met Thr Ile Phe Phe
     275                 280                 285

 aac act cac aat gag cca gtg cgg cag ttg gct att ttc tgt ccc cat     1090
 Asn Thr His Asn Glu Pro Val Arg Gln Leu Ala Ile Phe Cys Pro His
 290                 295                 300                 305

 gtg gca ctc caa aca acg atc tgt gaa gtc ctg gaa cgc tcc cac tct     1138
 Val Ala Leu Gln Thr Thr Ile Cys Glu Val Leu Glu Arg Ser His Ser
                 310                 315                 320

 cca ccc ctg aag ctg acc cct gcc tca agt acc cac cct aac ctc cat     1186
 Pro Pro Leu Lys Leu Thr Pro Ala Ser Ser Thr His Pro Asn Leu His
             325                 330                 335

 gcc tat ctt caa ggc aac acc cag gtc tct cga aag aaa ctt ctg ccc     1234
 Ala Tyr Leu Gln Gly Asn Thr Gln Val Ser Arg Lys Lys Leu Leu Pro
         340                 345                 350

 ctg ctc cag gaa gcc ctg tca gca tat ttt gac tcc atg aag atc cct     1282
 Leu Leu Gln Glu Ala Leu Ser Ala Tyr Phe Asp Ser Met Lys Ile Pro
     355                 360                 365

 tca gga cag cct gag aca gca gat gtg tcc agg gag caa gtg gac aag     1330
 Ser Gly Gln Pro Glu Thr Ala Asp Val Ser Arg Glu Gln Val Asp Lys
 370                 375                 380                 385

 gaa ttg gac agg gca agt aac tcc ctg att tct gga ctg agt caa gat     1378
 Glu Leu Asp Arg Ala Ser Asn Ser Leu Ile Ser Gly Leu Ser Gln Asp
                 390                 395                 400

 gag gag gac cct ccg ctg ccc ccg acg ccc atg aac agc ttg gtg gat     1426
 Glu Glu Asp Pro Pro Leu Pro Pro Thr Pro Met Asn Ser Leu Val Asp
             405                 410                 415

 gag tgc cct cta gat cag ggg ctg cct aaa ctc tct gct gag gcc gtc     1474
 Glu Cys Pro Leu Asp Gln Gly Leu Pro Lys Leu Ser Ala Glu Ala Val
         420                 425                 430

 ttc gag aag tgc agt cag atc tca ctg tca cag tct acc aca gcc tcc     1522
 Phe Glu Lys Cys Ser Gln Ile Ser Leu Ser Gln Ser Thr Thr Ala Ser
     435                 440                 445

 ctg tcc aag aag tga ctgttgagag gcgaggaggt agtgggtgag gctacctgac     1577
 Leu Ser Lys Lys 
 450

 tcacttc                                                             1584




      <210> 83
      <211> 784
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (65)..(439)

      <400> 83
 gaaacgctat gtattagagg aagctgagca actggagcct cgagttaatg ctctggaaga     60

 ggac atg gat gat gtg gag tcc agt gaa gag gaa gaa gag gag gat gag     109
      Met Asp Asp Val Glu Ser Ser Glu Glu Glu Glu Glu Glu Asp Glu
        1               5                  10                  15

 aag ttg gaa aga gtg cca tca cct gat cac cgc cgg aga agc tac cga      157
 Lys Leu Glu Arg Val Pro Ser Pro Asp His Arg Arg Arg Ser Tyr Arg
                  20                  25                  30

 gac ttg gac aag ccc cgt cgc tct ccc aca ctg cgc tac agg agg agt      205
 Asp Leu Asp Lys Pro Arg Arg Ser Pro Thr Leu Arg Tyr Arg Arg Ser
              35                  40                  45

 agg agc cgg tct ccc aga agg cgg agt cga tct ccc aaa agg aga agc      253
 Arg Ser Arg Ser Pro Arg Arg Arg Ser Arg Ser Pro Lys Arg Arg Ser
          50                  55                  60

 ccc tcc cct cgc cga gaa agg cat cgg agc aag agt cca aga cgt cac      301
 Pro Ser Pro Arg Arg Glu Arg His Arg Ser Lys Ser Pro Arg Arg His
      65                  70                  75

 cgc agc agg tcc cga gat cgg cgg cac aga tcc cgt tcc aag tcc cca      349
 Arg Ser Arg Ser Arg Asp Arg Arg His Arg Ser Arg Ser Lys Ser Pro
  80                  85                  90                  95

 ggt cat cac cgt agt cac aga cac agg agc cac tca aag tct ccc gaa      397
 Gly His His Arg Ser His Arg His Arg Ser His Ser Lys Ser Pro Glu
                 100                 105                 110

 agg tct aag aag agc cac aag aag agc cgg aga ggg aat gag taatgga      446
 Arg Ser Lys Lys Ser His Lys Lys Ser Arg Arg Gly Asn Glu 
             115                 120                 125

 ctcagtttgg ttttagtcca catggcctcc tgtggatata aggatatctg tatgtggaag    506

 gattaagatc tcccccaggc agctataaga atattttagt ttttttctta tcaagtttct    566

 caacctttat ttttaatgaa ggaggtgctg agttttgtat ctttttaatc ataatcaaca    626

 tcagtttttg acccaactaa ccttgactgt attcaaactt atgagagtat aaaggatctg    686

 gaggttgggg atatgactga caaggaaagg ctgtggccac ctgatgaccc tttccctttt    746

 tattaaaccg gacacacctg tttcccaaaa aaaaaaaa                            784




      <210> 84
      <211> 1350
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(822)

      <400> 84
  atg ccg agg gcg gag cca aga gcg aca ctg ggg gag cag gaa aag gcg      48
  Met Pro Arg Ala Glu Pro Arg Ala Thr Leu Gly Glu Gln Glu Lys Ala
    1               5                  10                  15

 ggg ctt ccg ctt ggg gca tgg agg ctg tac ctc tta cgt cac ttc cgt       96
 Gly Leu Pro Leu Gly Ala Trp Arg Leu Tyr Leu Leu Arg His Phe Arg
              20                  25                  30

 aaa caa acg gag ctg cgg agg agc ggg tcc cgg gat gtg acc ggg gct      144
 Lys Gln Thr Glu Leu Arg Arg Ser Gly Ser Arg Asp Val Thr Gly Ala
          35                  40                  45

 ctg ctt gtg gct gcg gcg gtg gct tct gag gct gtc ggg tct ttg cgg      192
 Leu Leu Val Ala Ala Ala Val Ala Ser Glu Ala Val Gly Ser Leu Arg
      50                  55                  60

 gtt gcg gaa ggg ggc ccc aat acc ctt ctt ctt cag gtc tta aga agc      240
 Val Ala Glu Gly Gly Pro Asn Thr Leu Leu Leu Gln Val Leu Arg Ser
  65                  70                  75                  80

 tgg ccg tgg tgc aat aag gaa ctt aaa aca atg gaa gag cgg aaa gtg      288
 Trp Pro Trp Cys Asn Lys Glu Leu Lys Thr Met Glu Glu Arg Lys Val
                  85                  90                  95

 aag agg agg agt cct aag tct ttt agt gcc cac tgt act cag gtt gtc      336
 Lys Arg Arg Ser Pro Lys Ser Phe Ser Ala His Cys Thr Gln Val Val
             100                 105                 110

 aat gcc aaa aaa aat gcc att cca gtg agt aaa agc aca ggg ttt tca      384
 Asn Ala Lys Lys Asn Ala Ile Pro Val Ser Lys Ser Thr Gly Phe Ser
         115                 120                 125

 aat cct gca tca cag tca act tca cag cga cca aag tta aaa aga gtg      432
 Asn Pro Ala Ser Gln Ser Thr Ser Gln Arg Pro Lys Leu Lys Arg Val
     130                 135                 140

 atg aaa gaa aag acc aaa cct cag ggt gga gag ggc aaa ggc gct cag      480
 Met Lys Glu Lys Thr Lys Pro Gln Gly Gly Glu Gly Lys Gly Ala Gln
 145                 150                 155                 160

 tca act ccg atc cag cac tcc ttc ctc act gat gtc tca gat gtt cag      528
 Ser Thr Pro Ile Gln His Ser Phe Leu Thr Asp Val Ser Asp Val Gln
                 165                 170                 175

 gag atg gag aga ggg ctg ctc agt ctt ttg aat gat ttc cac tct gga      576
 Glu Met Glu Arg Gly Leu Leu Ser Leu Leu Asn Asp Phe His Ser Gly
             180                 185                 190

 aaa ctt caa gca ttt gga aat gaa tgt tcc att gaa cag atg gaa cat      624
 Lys Leu Gln Ala Phe Gly Asn Glu Cys Ser Ile Glu Gln Met Glu His
         195                 200                 205

 gtt cgg gga atg cag gag aaa tta gct cgc ttg aat ttg gag ctc tat      672
 Val Arg Gly Met Gln Glu Lys Leu Ala Arg Leu Asn Leu Glu Leu Tyr
     210                 215                 220

 ggg gag tta gag gaa ctt cct gag gat aag aga aaa aca gcc agt gac      720
 Gly Glu Leu Glu Glu Leu Pro Glu Asp Lys Arg Lys Thr Ala Ser Asp
 225                 230                 235                 240

 tcc aat ctg gat agg ctt ctg tca gat tta gaa gaa ttg aat tct tcc      768
 Ser Asn Leu Asp Arg Leu Leu Ser Asp Leu Glu Glu Leu Asn Ser Ser
                 245                 250                 255

 ata caa aaa ctc cat ttg gca gat gca caa gat gtt cca aat act tct      816
 Ile Gln Lys Leu His Leu Ala Asp Ala Gln Asp Val Pro Asn Thr Ser
             260                 265                 270

 gct agc taaaatgaaa tgtagtttgc tttcttgtga tttgaagaga agcagcagtc       872
 Ala Ser 


 tttacttttc cagccaaatc cagtagcaga atcatcttcc acaacaagga attaaagtaa    932

 ttaaagtgca agttcaatga tcgttttcac ttactgcttt tagtaaatgt gactcgctgt    992

 aattcgccat aactggaggc ctaggccttg ttgaaggctt catcaggaaa tgtgacgcag   1052

 agattgtgct gctgtgcttc atattgttgc cttatgggat tatacttgaa atgcattgtg   1112

 ctgatgttct tgacagggcg gagggatttc tctttcctga gctcaccaaa cttattccag   1172

 tgttgatcgc aagctgttga tgcacaggcg tcttgtggca agcccagctt cagtttatgt   1232

 tagacaatca gtacacatgc tggtgtgttt tccaatggcc agtgataaga aattaaataa   1292

 gtatttgtga gatttgctat tttttaataa agtaattgtt ttaaattaaa aaaaaaaa     1350




      <210> 85
      <211> 3109
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (610)..(1479)

      <400> 85
 ttctttgggt tgactggatg gatcctttgc tccatggtgg ggattgctgg gttcatcatg     60

 cagatgcact caggagtgag tttggctgtg actgggatgt ccaagatggc ttcactcatg    120

 tgtctggtgc ctcaggtggg ttgtcttcgt gccagagcag aacatgcctt gtagttactg    180

 ccatattcta gccaagttac tccatttact gttcctttgt tcgtttttcg tcgctttccc    240

 acgatcacac agatctcagg tccaggagga cgcatcgtct ttttagtaac agtgcatgct    300

 gtgaggcttg tagagtcgcc tctctcttca ggcgcagcag agggcggccg caatagtacg    360

 ctcgcgcggc ggtggcgggt ggtggtcctt ggaccacgcg gtgggcggac agcggcacgg    420

 cctcccctcc cctccggacg caagccgaag tacgtgagag gagacttccg gccactgcgt    480

 tgtagtcggc ccggctgcaa agcgtttttc tgcaggctgt tttcccaggt tccctcggcc    540

 tgtacctcgc gcactcctct tgctccaggt ccttcagtct ccgctcgtct caccgtaggc    600

 tgtgacgac    atg agc aac aaa gaa gga tca gga ggg ttc agg aaa agg     648
              Met Ser Asn Lys Glu Gly Ser Gly Gly Phe Arg Lys Arg
                1               5                  10

 aag cat gac aat ttc cca cat aac caa aga aga gaa ggg aag gat gtt      696
 Lys His Asp Asn Phe Pro His Asn Gln Arg Arg Glu Gly Lys Asp Val
      15                  20                  25

 aat tca tct tca ccc gtg atg ttg gcc ttt aaa tca ttt cag cag gaa      744
 Asn Ser Ser Ser Pro Val Met Leu Ala Phe Lys Ser Phe Gln Gln Glu
  30                  35                  40                  45

 ctt gat gca agg cat gac aaa tat gag aga ctt gtg aaa ctt agt cgg      792
 Leu Asp Ala Arg His Asp Lys Tyr Glu Arg Leu Val Lys Leu Ser Arg
                  50                  55                  60

 gat ata act gtt gaa agt aaa agg aca att ttt ctc ctc cat agg att      840
 Asp Ile Thr Val Glu Ser Lys Arg Thr Ile Phe Leu Leu His Arg Ile
              65                  70                  75

 aca agt gct cct gat atg gaa gat ata ttg act gaa tca gaa att aaa      888
 Thr Ser Ala Pro Asp Met Glu Asp Ile Leu Thr Glu Ser Glu Ile Lys
          80                  85                  90

 ttg gat ggt gtc aga caa aag ata ttc cag gta gcc caa gag cta tca      936
 Leu Asp Gly Val Arg Gln Lys Ile Phe Gln Val Ala Gln Glu Leu Ser
      95                 100                 105

 ggg gaa gat atg cat cag ttc cat cga gcc att act aca gga cta cag      984
 Gly Glu Asp Met His Gln Phe His Arg Ala Ile Thr Thr Gly Leu Gln
 110                 115                 120                 125

 gaa tat gtg gaa gct gtc tct ttt caa cac ttc atc aaa aca cga tca     1032
 Glu Tyr Val Glu Ala Val Ser Phe Gln His Phe Ile Lys Thr Arg Ser
                 130                 135                 140

 tta att agt atg gat gaa att aat aaa caa ttg ata ttt acg act gaa     1080
 Leu Ile Ser Met Asp Glu Ile Asn Lys Gln Leu Ile Phe Thr Thr Glu
             145                 150                 155

 gac aat ggg aaa gaa aat aaa act ccc tcc tct gat gca cag gat aag     1128
 Asp Asn Gly Lys Glu Asn Lys Thr Pro Ser Ser Asp Ala Gln Asp Lys
         160                 165                 170

 cag ttt ggt act tgg aga ctg aga gtc aca cct gtc gat tac ctt ctg     1176
 Gln Phe Gly Thr Trp Arg Leu Arg Val Thr Pro Val Asp Tyr Leu Leu
     175                 180                 185

 gga gtg gct gac tta act gga gaa ttg atg cgg atg tgt att aac agt     1224
 Gly Val Ala Asp Leu Thr Gly Glu Leu Met Arg Met Cys Ile Asn Ser
 190                 195                 200                 205

 gtg ggg aat ggg gac att gat acc ccc ttt gaa gtg agc cag ttt tta     1272
 Val Gly Asn Gly Asp Ile Asp Thr Pro Phe Glu Val Ser Gln Phe Leu
                 210                 215                 220

 cgt cag gtt tat gat ggg ttt tca ttc att ggc aac act gga cct tac     1320
 Arg Gln Val Tyr Asp Gly Phe Ser Phe Ile Gly Asn Thr Gly Pro Tyr
             225                 230                 235

 gag gtt tct aag aag ctg tat acc ttg aaa caa agt ttg gcc aaa gtg     1368
 Glu Val Ser Lys Lys Leu Tyr Thr Leu Lys Gln Ser Leu Ala Lys Val
         240                 245                 250

 gag aat gct tgt tat gcc ttg aaa gtc aga ggg tca gaa att cca aaa     1416
 Glu Asn Ala Cys Tyr Ala Leu Lys Val Arg Gly Ser Glu Ile Pro Lys
     255                 260                 265

 cat atg ttg gca gat gtg ttt tca gtt aaa aca gaa atg ata gat caa     1464
 His Met Leu Ala Asp Val Phe Ser Val Lys Thr Glu Met Ile Asp Gln
 270                 275                 280                 285

 gaa gag ggc att tct tagaatctaa cgttactcag ttactaattc ttttgagaac     1519
 Glu Glu Gly Ile Ser 
                 290

 tcctaagaga ccaatttgta agacttattt agtatttcat ttaactttat tgtggctttt   1579

 acatagaaac atattcagtt gtacttgttt taaattgtat acaagctgta cataaaatta   1639

 gccaaatgaa tcatttctta tatcttattc atgaaagttt gcatacagat gtttgcatat   1699

 atgccttttt gaatttttgc tggttaacct ttatcattta tctttgtaat gtgaacatgc   1759

 ttcagagtgt accttttgcc ataacctatt ttaatttact ttttctgaag tttggagtga   1819

 taatttttag tggaagcaat ttgtaattta agttggtagt tatattatat atagaaaaga   1879

 ttttttagtt aaacttctgg acatgagcgt cctgtttaaa tttcttgtta atatcgtgcc   1939

 aagcctcaaa aataggctta ttccatggaa caagaattaa aaatgaataa gctatcaata   1999

 tataatttaa gtacaagttt aggctgggcg tggtggctca cgcctgtaat cccagcactt   2059

 tgggaggccg aggtaggcag atcacgaggt caagagatca agaccagcct gaccaacgtg   2119

 gcgaaacctc gtctctacta gaaatacaaa aattagctgg atatggtggt atgtgcctgt   2179

 aatcccagct acttgggagg ctgaggcagg agactcgctt gaacctggga ggcagaggtt   2239

 gcagtgagcc gagattgcgc cactgcactc cagcctgggt aacagagcaa gactccatct   2299

 caaaaaaaag aaagaaagaa aaaaagaaag tacaagttta taaagtatta tagtgaaaaa   2359

 ttcgcattct ggctgatttt aagccattta aaatttatat aaaacaacct tccataaaaa   2419

 tttgacaggt gcccagatgt tgctttctcc atttattttt tgtttttttt taatcacagt   2479

 aggtctgata gagaattgga gctaaattat aatatttttg ttggtaaagt tgagttatat   2539

 acttgtacat acaatggaaa tgcttttagt agtgattatt tagcaatttt tgtttttgtt   2599

 atattaggca tgtttggagg ctttcctatt ctagcattta aatttaaatt ttattaaaat   2659

 taaataattt aaatctagca tttaaattta aataatttaa gtctagcatt tacttttaaa   2719

 taattataat gaagttttga aatactaagt taatccagac ctttagttgt cccatggtgt   2779

 taataaagtt gccaaagaag atgtattatg aacaattcag caataagaca attgtcaaca   2839

 cagttgagaa taacaatggt aatcgttagt aatatttaga attggaattt gcctactgaa   2899

 atagttatag atgattactt gtgatgtgaa actgaattga gcatgacaac cagacatttc   2959

 cagttggttt tgtaagtttt gagaatctag atactgggtt ttattttttg aaagattagc   3019

 tctgtttgta agggctgatt ccttgaaaat gtaattttcc agaaaaacac ctaaagaaaa   3079

 taaaacatgg acatgcctaa aaaaaaaaaa                                    3109




      <210> 86
      <211> 890
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (208)..(831)

      <400> 86
 agttggctgg ttgcaccgat ctgggggctt cccgggctcg ggtaaccgga gtgctggtat     60

 ctaatcgtcg ctcaaaagct cctaggtgcg cgggtggata taattcccgg cttctcgaga    120

 agacactaca gcctcaagga ggtatatccc gtgccttacc tgactggggg ctctgagtcc    180

 agttgtgttg tcttcaactt agacacc    atg gag gca cct cca gtc acc atg     231
                                  Met Glu Ala Pro Pro Val Thr Met
                                    1               5

 atg cct gtc act ggg ggc acc att aac atg atg gag tac ctg ttg cag      279
 Met Pro Val Thr Gly Gly Thr Ile Asn Met Met Glu Tyr Leu Leu Gln
      10                  15                  20

 gga agt gtt tta gat cac agt ttg gaa agc ctc atc cac cgc ctt cgt      327
 Gly Ser Val Leu Asp His Ser Leu Glu Ser Leu Ile His Arg Leu Arg
  25                  30                  35                  40

 ggt ttg tgt gac aac atg gaa cct gag act ttc ctt gac cat gag atg      375
 Gly Leu Cys Asp Asn Met Glu Pro Glu Thr Phe Leu Asp His Glu Met
                  45                  50                  55

 gta ttc ctc ctt aag ggc cag caa gcc agc cca ttt gtt ctc agg gcc      423
 Val Phe Leu Leu Lys Gly Gln Gln Ala Ser Pro Phe Val Leu Arg Ala
              60                  65                  70

 cga cgc tct atg gac agg gca ggg gca ccc tgg cat ctg cgc tac ctg      471
 Arg Arg Ser Met Asp Arg Ala Gly Ala Pro Trp His Leu Arg Tyr Leu
          75                  80                  85

 gga cag cca gaa atg gga gac aag aac cgc cat gcc ctg gtg cga aac      519
 Gly Gln Pro Glu Met Gly Asp Lys Asn Arg His Ala Leu Val Arg Asn
      90                  95                 100

 tgc gtg gac att gcc aca tct gag aac ctc acc gac ttc ttg atg gaa      567
 Cys Val Asp Ile Ala Thr Ser Glu Asn Leu Thr Asp Phe Leu Met Glu
 105                 110                 115                 120

 atg ggc ttc cgc atg gac cat gag ttt gtt gct aag gga cat ttg ttc      615
 Met Gly Phe Arg Met Asp His Glu Phe Val Ala Lys Gly His Leu Phe
                 125                 130                 135

 cgt aag ggc atc atg aag att atg gtg tac aag att ttc cgc atc ctg      663
 Arg Lys Gly Ile Met Lys Ile Met Val Tyr Lys Ile Phe Arg Ile Leu
             140                 145                 150

 gtg cca ggg aac aca gac agc act gag gcc ttg tca ctc tcc tat ctc      711
 Val Pro Gly Asn Thr Asp Ser Thr Glu Ala Leu Ser Leu Ser Tyr Leu
         155                 160                 165

 gtg gaa tta agt gtg gta gca ccc gct ggg cag gac atg gtc tct gat      759
 Val Glu Leu Ser Val Val Ala Pro Ala Gly Gln Asp Met Val Ser Asp
     170                 175                 180

 gac atg aag aac ttc gca gaa cag cta aaa cct ctg gtt cac cta gag      807
 Asp Met Lys Asn Phe Ala Glu Gln Leu Lys Pro Leu Val His Leu Glu
 185                 190                 195                 200

 aaa ata gac ccc aag agg ctc atg tgactaagag gatctgtcca catttggggc     861
 Lys Ile Asp Pro Lys Arg Leu Met 
                 205

 ctatccttac ttgtttgaaa aaaaaaaaa                                      890




      <210> 87
      <211> 1044
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (85)..(387)

      <400> 87
 ggaatacttc caagttgtag tgttgttgtt ttcagcctgc tgctgctgct gctgttgcgg     60

 ctaggggaac cgtcgtgggg aagg   atg gtg tgc gaa aaa tgt gaa aag aaa     111
                              Met Val Cys Glu Lys Cys Glu Lys Lys
                                1               5

 ctt ggt act gtt atc act cca gat aca tgg aaa gat ggt gct agg aat      159
 Leu Gly Thr Val Ile Thr Pro Asp Thr Trp Lys Asp Gly Ala Arg Asn
  10                  15                  20                  25

 acc aca gaa agt ggt gga aga aag ctg aat gaa aat aaa gct ttg act      207
 Thr Thr Glu Ser Gly Gly Arg Lys Leu Asn Glu Asn Lys Ala Leu Thr
                  30                  35                  40

 tca aaa aaa gca aga ttt gat cca tat gga aag aat aag ttc tcc act      255
 Ser Lys Lys Ala Arg Phe Asp Pro Tyr Gly Lys Asn Lys Phe Ser Thr
              45                  50                  55

 tgt aga att tgt aaa agt tct gtg cac caa cca ggt tct cat tac tgc      303
 Cys Arg Ile Cys Lys Ser Ser Val His Gln Pro Gly Ser His Tyr Cys
          60                  65                  70

 cag ggc tgt gcc tac aaa aaa ggc atc tgt gcg atg tgt gga aaa aag      351
 Gln Gly Cys Ala Tyr Lys Lys Gly Ile Cys Ala Met Cys Gly Lys Lys
      75                  80                  85

 gtt ttg gat acc aaa aac tac aag caa aca tct gtc taga tgtattgatg      401
 Val Leu Asp Thr Lys Asn Tyr Lys Gln Thr Ser Val 
  90                  95                 100

 gaatttctgg ctttctaaat gattttactt tctgccttga attttcaagg catagatgtc    461

 aacttacaga ataacatgtt ttaagataat taagtttaaa ccagagaatt tgattgttac    521

 tcattttgct ctcatgttct aaacagcaac agtgtaacta gtcttttgtt gtaaatggtt    581

 attttcctta taagaatttt aagaactaag tggcaaattc catgaaaata tttctcagtt    641

 ctgtatgcac ttttatttaa cattattcat ataattctcc ccccaccact ttatttatag    701

 atactgcaaa agtgagaagg agataataga tactttgctc tgaatttggc atccagagtt    761

 aacatttctc ccctcactcc cttgctggtg tcatagttat tagaatcagc agcctcttaa    821

 ctaattgcgg tttcatagga tatataaatg tttcaagcca ttattgctga atggttcttt    881

 agttattaac ctagacccaa atcaaagacc agttggattt atgatatttt ttatttgttc    941

 ttgcagccaa agtgccagtt tctttaatat gtgaccaaga acacaaggag catccatatg   1001

 gccaaataaa tacactgaat tttagaaaaa caaaaaaaaa aaa                     1044




      <210> 88
      <211> 1467
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (5)..(1165)

      <400> 88
 agcc atg gcg gga agc gag ccg cgc agc gga aca aac tcg ccg ccg ccg      49
      Met Ala Gly Ser Glu Pro Arg Ser Gly Thr Asn Ser Pro Pro Pro
        1               5                  10                  15

 ccc ttc agc gac tgg ggc cgc ctg gag gcg gcc atc ctc agc ggc tgg       97
 Pro Phe Ser Asp Trp Gly Arg Leu Glu Ala Ala Ile Leu Ser Gly Trp
                  20                  25                  30

 aag acc ttc tgg cag tca gtg agc aag gag agg gtg gcg cgt acg acc      145
 Lys Thr Phe Trp Gln Ser Val Ser Lys Glu Arg Val Ala Arg Thr Thr
              35                  40                  45

 tca cgg gag gag gtg gat gag gcg gcc agc acc ctg acg cgg ctg ccg      193
 Ser Arg Glu Glu Val Asp Glu Ala Ala Ser Thr Leu Thr Arg Leu Pro
          50                  55                  60

 att gat gta cag cta tat att ttg tcc ttt ctt tca cct cat gat ctg      241
 Ile Asp Val Gln Leu Tyr Ile Leu Ser Phe Leu Ser Pro His Asp Leu
      65                  70                  75

 tgt cag ttg gga agt aca aat cat tat tgg aat gaa act gta aga gat      289
 Cys Gln Leu Gly Ser Thr Asn His Tyr Trp Asn Glu Thr Val Arg Asp
  80                  85                  90                  95

 cca att ctg tgg aga tac ttt ttg ttg agg gat ctt cct tct tgg tct      337
 Pro Ile Leu Trp Arg Tyr Phe Leu Leu Arg Asp Leu Pro Ser Trp Ser
                 100                 105                 110

 tct gtt gac tgg aag tct ctt cca gat cta gaa atc tta aaa aag cct      385
 Ser Val Asp Trp Lys Ser Leu Pro Asp Leu Glu Ile Leu Lys Lys Pro
             115                 120                 125

 ata tct gag gtc act gat ggt gca ttt ttt gac tac atg gca gtc tat      433
 Ile Ser Glu Val Thr Asp Gly Ala Phe Phe Asp Tyr Met Ala Val Tyr
         130                 135                 140

 aga atg tgc tgt cca tac aca aga aga gct tca aaa tcc agc cgt cct      481
 Arg Met Cys Cys Pro Tyr Thr Arg Arg Ala Ser Lys Ser Ser Arg Pro
     145                 150                 155

 atg tat gga gct gtc act tct ttt tta cac tcc ctg atc att cag aat      529
 Met Tyr Gly Ala Val Thr Ser Phe Leu His Ser Leu Ile Ile Gln Asn
 160                 165                 170                 175

 gaa cca cga ttt gct atg ttt gga cca ggt ttg gaa gaa ttg aat acc      577
 Glu Pro Arg Phe Ala Met Phe Gly Pro Gly Leu Glu Glu Leu Asn Thr
                 180                 185                 190

 tct ttg gtg ttg agc ttg atg tct tca gag gaa ctt tgc cca aca gct      625
 Ser Leu Val Leu Ser Leu Met Ser Ser Glu Glu Leu Cys Pro Thr Ala
             195                 200                 205

 ggt ttg cct cag agg cag att gat ggt att gga tca gga gtc aat ttt      673
 Gly Leu Pro Gln Arg Gln Ile Asp Gly Ile Gly Ser Gly Val Asn Phe
         210                 215                 220

 cag ttg aac aac caa cat aaa ttc aac att cta atc tta tat tca act      721
 Gln Leu Asn Asn Gln His Lys Phe Asn Ile Leu Ile Leu Tyr Ser Thr
     225                 230                 235

 acc aga aag gaa aga gat aga gca agg gaa gag cat aca agt gca gtt      769
 Thr Arg Lys Glu Arg Asp Arg Ala Arg Glu Glu His Thr Ser Ala Val
 240                 245                 250                 255

 aac aag atg ttc agt cga cac aat gaa ggt gat gat caa caa gga agc      817
 Asn Lys Met Phe Ser Arg His Asn Glu Gly Asp Asp Gln Gln Gly Ser
                 260                 265                 270

 cgg tac agt gtg att cca cag att caa aaa gtg tgt gaa gtt gta gat      865
 Arg Tyr Ser Val Ile Pro Gln Ile Gln Lys Val Cys Glu Val Val Asp
             275                 280                 285

 ggg ttc atc tat gtt gca aat gct gaa gct cat aaa aga cat gaa tgg      913
 Gly Phe Ile Tyr Val Ala Asn Ala Glu Ala His Lys Arg His Glu Trp
         290                 295                 300

 caa gat gaa ttt tct cat att atg gca atg aca gat cca gcc ttt ggg      961
 Gln Asp Glu Phe Ser His Ile Met Ala Met Thr Asp Pro Ala Phe Gly
     305                 310                 315

 tct tcg gga aga cca ttg ttg gtt tta tct tgt att tct caa ggg gat     1009
 Ser Ser Gly Arg Pro Leu Leu Val Leu Ser Cys Ile Ser Gln Gly Asp
 320                 325                 330                 335

 gta aaa aga atg ccc tgt ttt tat ttg gct cat gag ctg cat ctg aat     1057
 Val Lys Arg Met Pro Cys Phe Tyr Leu Ala His Glu Leu His Leu Asn
                 340                 345                 350

 ctt cta aat cac cca tgg ctg gtc cag gat aca gag gct gaa act ctg     1105
 Leu Leu Asn His Pro Trp Leu Val Gln Asp Thr Glu Ala Glu Thr Leu
             355                 360                 365

 act ggt ttt ttg aat ggc att gag tgg att ctt gaa gaa gtg gaa tct     1153
 Thr Gly Phe Leu Asn Gly Ile Glu Trp Ile Leu Glu Glu Val Glu Ser
         370                 375                 380

 aag cgt gca aga tga ttctcttttc agatcttggg aactgaaacc atttgaaatt     1208
 Lys Arg Ala Arg 
     385

 tattactaag gtcgtgatgt gaatatttgc tcagtcagcc caccttgtcc tgcctttttg   1268

 cagataggct ttcatttgga cagctataac tgctgtgttt tttatattat ttttactctt   1328

 taccataaat caattacaag aaaagagttt cagtcctagt atttagcccc aaaatgaacc   1388

 tttaaacatt tttttggtaa tttttatatt ttctgtcttt ttaaaaatat taaattctgg   1448

 aaaaaacaaa aaaaaaaaa                                                1467




      <210> 89
      <211> 894
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (72)..(536)

      <400> 89
 ggccaagtag agctccgtcc tgacgcgccg cctcccgtgg gctccggccg gctaagccgc     60

 ggcggacaac t atg ctg aaa gcc aag atc ctc ttc gtg ggg cct tgc gag     110
              Met Leu Lys Ala Lys Ile Leu Phe Val Gly Pro Cys Glu
                1               5                  10

 agt gga aaa act gtt ttg gcc aac ttt ctg aca gaa tct tct gac atc      158
 Ser Gly Lys Thr Val Leu Ala Asn Phe Leu Thr Glu Ser Ser Asp Ile
      15                  20                  25

 act gaa tac agc cca acc caa gga gtg agg ttt gag tcc tgc tgg ccg      206
 Thr Glu Tyr Ser Pro Thr Gln Gly Val Arg Phe Glu Ser Cys Trp Pro
  30                  35                  40                  45

 gcc ctg atg aag gat gct cat gga gtg gtg atc gtc ttc aat gct gac      254
 Ala Leu Met Lys Asp Ala His Gly Val Val Ile Val Phe Asn Ala Asp
                  50                  55                  60

 atc cca agc cac cgg aag gaa atg gag atg tgg tat tcc tgc ttt gtc      302
 Ile Pro Ser His Arg Lys Glu Met Glu Met Trp Tyr Ser Cys Phe Val
              65                  70                  75

 caa cag ccg tcc tta cag gac aca cag tgt atg cta att gca cac cac      350
 Gln Gln Pro Ser Leu Gln Asp Thr Gln Cys Met Leu Ile Ala His His
          80                  85                  90

 aaa cca ggc tct gga gat gat aaa gga agc ctg tct ttg tcg cca ccc      398
 Lys Pro Gly Ser Gly Asp Asp Lys Gly Ser Leu Ser Leu Ser Pro Pro
      95                 100                 105

 ttg aac aag ctg aag ctg gtg cac tca aac ctg gaa gat gac cct gag      446
 Leu Asn Lys Leu Lys Leu Val His Ser Asn Leu Glu Asp Asp Pro Glu
 110                 115                 120                 125

 gag atc cgg atg gaa ttc ata aag tat tta aaa agc ata atc aac tcc      494
 Glu Ile Arg Met Glu Phe Ile Lys Tyr Leu Lys Ser Ile Ile Asn Ser
                 130                 135                 140

 atg tct gag agc aga gac agg gag gag atg tca att atg acc tagccag      543
 Met Ser Glu Ser Arg Asp Arg Glu Glu Met Ser Ile Met Thr 
             145                 150                 155

 ccttcacctg ggactgccac atccccagtg aaatcagcat gtttctcggt gcagatctga    603

 aatcacatcc agctcctgat gttttcttct ccctctgact gcagaggaag tgttcctacc    663

 tgcaggaagg cacctgtcac acagggcgtt cactcagacc atctgtgctc tgccctgagt    723

 tcagttgaga aaatcctatt atcaaatttg gatttcctgg ccccagaact tcccaaagac    783

 ctgtaaaatg gagggattta ccacctcaca tatgtccagt taaacagttt gtggacttgt    843

 aaccgtcgca gcccaatgat acaacagtag tttaatcacg aaaaaaaaaa a             894




      <210> 90
      <211> 1060
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (623)..(1057)

      <400> 90
 accatgagtt cttattatat atatgtatat atccaaatta acaaaattgt gtctgaagtt     60

 gagtaactaa taaaaatgaa tcttactctt tttttctttt tttttaagat ggagttttgc    120

 tcttgtcacc caggcgggag tgcaatggcg tgatctcggc tcactgcaac cttcgcctcc    180

 tgggttcaag cgattctcct gcctcagccc cccaagtagc tgggattaca gatgcccgct    240

 accacgcctg gctaattttt gcgtacagac ggggtttcac catgttggcc aggctggtct    300

 caaactcctg acctcaagtg atctgcccgc cttggcctcc caggtccagt gtaaactcgt    360

 ggtccctgca tctgcagaaa ggcacatttc ccctctgcag cgcggactga ttgcgttctc    420

 gctgcgtcca gatccagggc tcgccggcga cagagccagt ctcggggtcc cactgtgcgg    480

 ataccggatt ggtaatccga ggcggagccc taagcgcaca cgccattgcg cccggacagc    540

 ggctgtctca tgctctgcat acagcaagtg cttatatcaa ttcaggccga atgtgggaca    600

 cagtgcatct accccaaaag cg atg tgt cag acc acg gcc gca ggg gag ggt     652
                          Met Cys Gln Thr Thr Ala Ala Gly Glu Gly
                            1               5                  10

 gcg cac gcc gcg gac gag ggc tac aca caa aga gta gtg gga gcg agg      700
 Ala His Ala Ala Asp Glu Gly Tyr Thr Gln Arg Val Val Gly Ala Arg
                  15                  20                  25

 cga ggg aca cct caa cgc tac acg ggc ggg gca gag act aag aac cga      748
 Arg Gly Thr Pro Gln Arg Tyr Thr Gly Gly Ala Glu Thr Lys Asn Arg
              30                  35                  40

 gcc ttt cgc agc tac ccc aaa atg gag acc tct tgg ccg cgc ggc gga      796
 Ala Phe Arg Ser Tyr Pro Lys Met Glu Thr Ser Trp Pro Arg Gly Gly
          45                  50                  55

 ggg agc acc ccg cct gta gca ctg gat gca caa gtg gag cgc gag tgc      844
 Gly Ser Thr Pro Pro Val Ala Leu Asp Ala Gln Val Glu Arg Glu Cys
      60                  65                  70

 gct cta ggg tct ggc gcg cag ggc aag cac tcg tgc ctg gct gtg cgg      892
 Ala Leu Gly Ser Gly Ala Gln Gly Lys His Ser Cys Leu Ala Val Arg
  75                  80                  85                  90

 gtt gtg ctt ata ttt tgc att aac gaa cat tac ccc caa aca ctc acc      940
 Val Val Leu Ile Phe Cys Ile Asn Glu His Tyr Pro Gln Thr Leu Thr
                  95                 100                 105

 tac cga tta cct ttc gtg ctt cct ctc cgc tca ggg gga acc cca acc      988
 Tyr Arg Leu Pro Phe Val Leu Pro Leu Arg Ser Gly Gly Thr Pro Thr
             110                 115                 120

 tcc tgg aga gct ctg ttc ttt ccc agt tcc agc gac tct aac tgt aag     1036
 Ser Trp Arg Ala Leu Phe Phe Pro Ser Ser Ser Asp Ser Asn Cys Lys
         125                 130                 135

 ctc tgt ggg ggc acg agc tca tag                                     1060
 Leu Cys Gly Gly Thr Ser Ser 
     140                 145





      <210> 91
      <211> 1349
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (329)..(829)

      <400> 91
 gacaggaccg tgtttgttgg gaatttagag gcccgagttc gggaagagat tctgtacgag     60

 ctgttccttc agtttcttat aggcggggcc actaaccaaa gtgactatat gcaaagacag    120

 agaaggaaag ccaaagtctt ttggatttgt ctgctttaaa cacccagaat cggtgtctta    180

 tgccatagct ttgctgaatg gaattcgttt atatggaaga ccaattaacg tgcagtatcg    240

 atttgggagt tctcgctctt ctgaaccagc taaccaaagt tttgagagct gtgttaagat    300

 aaattcacac aactacagga atgaagaa   atg gtg gtg ggc aga tct tcc ttt     352
                                  Met Val Val Gly Arg Ser Ser Phe
                                    1               5

 ccc atg cag tat ttt cca att aat aat act tct tta cct caa gaa tat      400
 Pro Met Gln Tyr Phe Pro Ile Asn Asn Thr Ser Leu Pro Gln Glu Tyr
      10                  15                  20

 ttt ctc ttt cag aag atg cag tgg cat gtg tat aat cca gtg ctg cag      448
 Phe Leu Phe Gln Lys Met Gln Trp His Val Tyr Asn Pro Val Leu Gln
  25                  30                  35                  40

 ctt cct tac tat gaa atg aca gct cca ctt cct aat agt gca tcc gtg      496
 Leu Pro Tyr Tyr Glu Met Thr Ala Pro Leu Pro Asn Ser Ala Ser Val
                  45                  50                  55

 tct tcc tca ctg aat cat gtt cca gat ctt gag gct gga ccc agc tca      544
 Ser Ser Ser Leu Asn His Val Pro Asp Leu Glu Ala Gly Pro Ser Ser
              60                  65                  70

 tat aaa tgg act cac caa caa cca agt gac tct gac ctt tat cag atg      592
 Tyr Lys Trp Thr His Gln Gln Pro Ser Asp Ser Asp Leu Tyr Gln Met
          75                  80                  85

 aca gct cca ctt cct aat agt gca tcc gtg tct tcc tca ctg aat cat      640
 Thr Ala Pro Leu Pro Asn Ser Ala Ser Val Ser Ser Ser Leu Asn His
      90                  95                 100

 gtt cca gat ctt gag gct gga ccc agc tca tat aaa tgg act cgc caa      688
 Val Pro Asp Leu Glu Ala Gly Pro Ser Ser Tyr Lys Trp Thr Arg Gln
 105                 110                 115                 120

 caa cca agt gac tct gac ctt tat cag atg aat aaa cga aag aga caa      736
 Gln Pro Ser Asp Ser Asp Leu Tyr Gln Met Asn Lys Arg Lys Arg Gln
                 125                 130                 135

 aag caa aca agt gat agt gat agt agc aca gac aac aac aga ggc aac      784
 Lys Gln Thr Ser Asp Ser Asp Ser Ser Thr Asp Asn Asn Arg Gly Asn
             140                 145                 150

 gaa tgt agc caa aag ttc cga aag tct aag aag aag aaa aga tac tag      832
 Glu Cys Ser Gln Lys Phe Arg Lys Ser Lys Lys Lys Lys Arg Tyr 
         155                 160                 165

 tattacctac aaatgaaact tacctacact gatcttagtt ctcttatgaa aaaaaataag    892

 atgttatccc atcaaataaa caatgtcatg gctatcttgt cttttgaaat atgtagtaat    952

 aagacttatc tctggtttgc tgttcaattt ttgccttgaa cgacaaaagc tttctaaaaa   1012

 tagtataatg taccactttt tgtatttgtc atgatatttt tgacccattg gcaacaaata   1072

 gactattgtc attttattag taccaatgat gaaatttcac caaactatta atcaaaagtc   1132

 acttattgaa cacattgata aagcatcatg ttccctttga ttatccccta taaccaacac   1192

 tcaactacaa ataggctggg attcaatgtg gagtggtgga tttcctgaaa gaaagtagtg   1252

 cagatattta aggattgcat attggtccta atgaggatgt aataaacagg cattagtacc   1312

 cctttctttt agtacctaaa tatgttgttt ctgagcc                            1349




      <210> 92
      <211> 2840
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (163)..(1287)

      <400> 92
 tgaaaatctt gttgattctg gggagccgag cgcgcggcgc gagcgtcacg ccagacagcg     60

 gcccgcgcgc cttctcctcg gcgtcggccg ccgccgcctc ccagaacctc ctcgtgccct    120

 cgcgtgccag gcccgcggcg gccgaaatcc gcggttcaca gc   atg tcc gcc tcg     174
                                                  Met Ser Ala Ser
                                                    1

 gcc cct gct gcg gag ggg gag gga acc ccc acc cag ccc gcg tcc gag      222
 Ala Pro Ala Ala Glu Gly Glu Gly Thr Pro Thr Gln Pro Ala Ser Glu
   5                  10                  15                  20

 aaa gaa ccc gaa atg ccc ggt ccc aga gag gag agc gag gag gaa gag      270
 Lys Glu Pro Glu Met Pro Gly Pro Arg Glu Glu Ser Glu Glu Glu Glu
                  25                  30                  35

 gac gag gac gac gag gag gag gag gag gag gaa aaa gaa aag agt ctc      318
 Asp Glu Asp Asp Glu Glu Glu Glu Glu Glu Glu Lys Glu Lys Ser Leu
              40                  45                  50

 atc gtg gaa ggc aag agg gaa aag aaa aaa gta gag agg ttg aca atg      366
 Ile Val Glu Gly Lys Arg Glu Lys Lys Lys Val Glu Arg Leu Thr Met
          55                  60                  65

 caa gtc tct tcc tta cag aga gag cca ttt aca att gca caa gga aag      414
 Gln Val Ser Ser Leu Gln Arg Glu Pro Phe Thr Ile Ala Gln Gly Lys
      70                  75                  80

 ggg cag aaa ctt tgt gaa att gag agg ata cat ttt ttt cta agt aag      462
 Gly Gln Lys Leu Cys Glu Ile Glu Arg Ile His Phe Phe Leu Ser Lys
  85                  90                  95                 100

 aag aaa acc gat gaa ctt aga aat cta cac aaa ctg ctt tac aac agg      510
 Lys Lys Thr Asp Glu Leu Arg Asn Leu His Lys Leu Leu Tyr Asn Arg
                 105                 110                 115

 cca ggc act gtg tcc tca tta aag aag aat gtg ggt cag ttc agt ggc      558
 Pro Gly Thr Val Ser Ser Leu Lys Lys Asn Val Gly Gln Phe Ser Gly
             120                 125                 130

 ttt cca ttt gaa aaa gga agt gtc caa tat aaa aag aag gaa gaa atg      606
 Phe Pro Phe Glu Lys Gly Ser Val Gln Tyr Lys Lys Lys Glu Glu Met
         135                 140                 145

 ttg aaa aaa ttt aga aat gcc atg tta aag agc atc tgt gag gtt ctt      654
 Leu Lys Lys Phe Arg Asn Ala Met Leu Lys Ser Ile Cys Glu Val Leu
     150                 155                 160

 gat ttg gag aga tca ggt gta aat agt gaa cta gtg aag agg atc ttg      702
 Asp Leu Glu Arg Ser Gly Val Asn Ser Glu Leu Val Lys Arg Ile Leu
 165                 170                 175                 180

 aat ttc tta atg cat cca aag cct tct ggc aaa cca ttg ccg aaa tct      750
 Asn Phe Leu Met His Pro Lys Pro Ser Gly Lys Pro Leu Pro Lys Ser
                 185                 190                 195

 aaa aaa act tgt agc aaa ggc agt aaa aag gaa cgg aac agt tct gga      798
 Lys Lys Thr Cys Ser Lys Gly Ser Lys Lys Glu Arg Asn Ser Ser Gly
             200                 205                 210

 atg gca agg aag gct aag cga acc aaa tgt cct gaa att ctg tca gat      846
 Met Ala Arg Lys Ala Lys Arg Thr Lys Cys Pro Glu Ile Leu Ser Asp
         215                 220                 225

 gaa tct agt agt gat gaa gat gaa aag aaa aac aag gaa gag tct tca      894
 Glu Ser Ser Ser Asp Glu Asp Glu Lys Lys Asn Lys Glu Glu Ser Ser
     230                 235                 240

 gat gat gaa gat aaa gaa agt gaa gag gag cca cca aaa aag aca gcc      942
 Asp Asp Glu Asp Lys Glu Ser Glu Glu Glu Pro Pro Lys Lys Thr Ala
 245                 250                 255                 260

 aaa aga gaa aaa cct aaa cag aaa gct act tct aaa agt aaa aaa tct      990
 Lys Arg Glu Lys Pro Lys Gln Lys Ala Thr Ser Lys Ser Lys Lys Ser
                 265                 270                 275

 gtg aaa agt gcc aat gtt aag aaa gca gat agc agc acc acc aag aag     1038
 Val Lys Ser Ala Asn Val Lys Lys Ala Asp Ser Ser Thr Thr Lys Lys
             280                 285                 290

 aat caa aac agt tcc aaa aaa gaa agt gag tct gag gat agt tca gat     1086
 Asn Gln Asn Ser Ser Lys Lys Glu Ser Glu Ser Glu Asp Ser Ser Asp
         295                 300                 305

 gat gaa cct tta att aaa aag ttg aag aaa ccc cct aca gat gaa gag     1134
 Asp Glu Pro Leu Ile Lys Lys Leu Lys Lys Pro Pro Thr Asp Glu Glu
     310                 315                 320

 tta aag gaa aca ata aag aaa tta ctg gcc agt gct aac ttg gaa gaa     1182
 Leu Lys Glu Thr Ile Lys Lys Leu Leu Ala Ser Ala Asn Leu Glu Glu
 325                 330                 335                 340

 gtc aca atg aaa cag att tgc aaa aag gtc tat gaa aat tat cct act     1230
 Val Thr Met Lys Gln Ile Cys Lys Lys Val Tyr Glu Asn Tyr Pro Thr
                 345                 350                 355

 tat gat tta act gaa aga aaa gat ttc ata aaa aca act gta aaa gag     1278
 Tyr Asp Leu Thr Glu Arg Lys Asp Phe Ile Lys Thr Thr Val Lys Glu
             360                 365                 370

 cta att tct tgagata gaggacagag aagatgactc gttcccatag atttgaagat     1334
 Leu Ile Ser 
         375

 ctgatttata ccattatacc agcaaagaga atgtatttcc ttttctaaat ccttgttaag   1394

 caacgttagt agaacttact gctgaccttt ttatcttgag tgttatgtga atttgagttt   1454

 gctgttttaa attgcatttc tatgccattt ttagtttaaa atcttgcatg gcattaattg   1514

 ttccttgctt ttatagttgt attttgtaca ttttggattt ctttatataa ggtcatagat   1574

 tcttgagctg ttgtggtttt tagtgcactt aatattagct tgcttaaggc atacttttaa   1634

 tcaagtagaa caaaaactat tatcaccagg atttatacat acagagattg tagtatttag   1694

 tatatgaaat attttgaata cacatctctg tcagtgtgaa aattcagcgg cagtgtgtcc   1754

 atcatattaa aaatatacaa gctacagttg tccagatcac tgaattggaa cttttctcct   1814

 gcatgtgtat atatgtcaaa ttgtcagcat gacaaaagtg acagatgtta tttttgtatt   1874

 tttaaaaaac aattggttgt atataaagtt tttttatttc ttttgtgcag atcacttttt   1934

 aaactcacat aggtaggtat ctttatagtt gtagactatg gaatgtcagt gttcagccaa   1994

 acagtatgat ggaacagtga aagtcaattc agtgatggca acactgaagg aacagttacc   2054

 ctgctttgcc tcgaaagtgt catcaatttg taattttagt attaactctg taaaagtgtc   2114

 tgtaggtacg ttttatatta tataaggaca gaccaaaaat caacctatca aagcttcaaa   2174

 aactttggga aagggtggga ttaagtacaa gcacatttgg cttacagtaa atgaactgat   2234

 ttttattaac tgcttttgcc catataaaat gctgatattt actggaaacc tagccagctt   2294

 cacgattatg actaaagtac cagattataa tgccagaata taatgtgcag gcaatcgtgg   2354

 atgtctctga caaagtgtgt ctcaaaaata atatactttt acattaaaga aatttaatgt   2414

 ttctctggag ttggggctct tggctttcag agtttggtta atcagtgttg attctagatg   2474

 atcaacataa tggaccactc ctgaatgaga cttaattttg tctttcaaat ttactgtctt   2534

 aaatcagttt attaaatctg aattttaaaa catgctgttt atgacacaat gacacatttg   2594

 ttgcaccaat taagtgttga aaaatatctt tgcatcatag aacagaaata tataaaaata   2654

 tatgttgaat gttaacaggt attttcacag gtttgtttct tgatagttac tcagacacta   2714

 gggaaaggta aatacaagtg aacaaaataa gcaactaaat gagacctaat aattggcctt   2774

 cgattttaaa tatttgttct tataaacctt gtcaataaaa ataaatctaa atcaaaaaaa   2834

 aaaaaa                                                              2840




      <210> 93
      <211> 1258
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (111)..(977)

      <400> 93
 taagcttgcg gccgctcctc gcctggctgc agcggcggca gccccagtgc tgcccctgtg     60

 cggcgcccct ttcccgctcc gccgcgcact gttgtcatgg aggaaccaag   atg gcg     116
                                                          Met Ala
                                                            1

 gct ctg gcc tac aac ctg ggc aag cgg gag atc aac cac tac ttc agc      164
 Ala Leu Ala Tyr Asn Leu Gly Lys Arg Glu Ile Asn His Tyr Phe Ser
           5                  10                  15

 gtg agg agc gcc aag gtg ctg gcg ctg gtg gcc gtg ctg ctg ctc gca      212
 Val Arg Ser Ala Lys Val Leu Ala Leu Val Ala Val Leu Leu Leu Ala
      20                  25                  30

 gcg tgc cac ctc gcc tcc cgc cgc tac cga ggc aat gat tcg tgt gaa      260
 Ala Cys His Leu Ala Ser Arg Arg Tyr Arg Gly Asn Asp Ser Cys Glu
  35                  40                  45                  50

 tac ctt ctc tca agt ggc aga ttt ctt gga gag aaa gtt tgg caa cct      308
 Tyr Leu Leu Ser Ser Gly Arg Phe Leu Gly Glu Lys Val Trp Gln Pro
                  55                  60                  65

 cac agt tgt atg atg cat aaa tac aaa atc agt gaa gca aag aac tgc      356
 His Ser Cys Met Met His Lys Tyr Lys Ile Ser Glu Ala Lys Asn Cys
              70                  75                  80

 ctt gta gat aaa cat att gca ttt att gga gat tcc aga att cgt caa      404
 Leu Val Asp Lys His Ile Ala Phe Ile Gly Asp Ser Arg Ile Arg Gln
          85                  90                  95

 ttg ttt tat tct ttt gta aaa ata att aat ccc caa ttc aaa gaa gaa      452
 Leu Phe Tyr Ser Phe Val Lys Ile Ile Asn Pro Gln Phe Lys Glu Glu
     100                 105                 110

 gga aat aag cat gaa aac att cct ttt gaa gac aag act gca tca gtt      500
 Gly Asn Lys His Glu Asn Ile Pro Phe Glu Asp Lys Thr Ala Ser Val
 115                 120                 125                 130

 aaa gtg gat ttt ctg tgg cat cct gaa gtt aat ggt tct atg aaa cag      548
 Lys Val Asp Phe Leu Trp His Pro Glu Val Asn Gly Ser Met Lys Gln
                 135                 140                 145

 tgt atc aaa gtg tgg act gag gat tcc att gca aag cca cat gtg att      596
 Cys Ile Lys Val Trp Thr Glu Asp Ser Ile Ala Lys Pro His Val Ile
             150                 155                 160

 gta gca gga gct gcc aca tgg tcc atc aag att cac aat ggt agc agt      644
 Val Ala Gly Ala Ala Thr Trp Ser Ile Lys Ile His Asn Gly Ser Ser
         165                 170                 175

 gaa gcg ctt tct caa tat aaa atg aac atc acc tcc ata gca cca ctt      692
 Glu Ala Leu Ser Gln Tyr Lys Met Asn Ile Thr Ser Ile Ala Pro Leu
     180                 185                 190

 tta gaa aaa ttg gca aag act agt gat gtt tat tgg gtc tta caa gat      740
 Leu Glu Lys Leu Ala Lys Thr Ser Asp Val Tyr Trp Val Leu Gln Asp
 195                 200                 205                 210

 cct gtt tat gaa gat cta tta agt gaa aat agg aag atg atc act aat      788
 Pro Val Tyr Glu Asp Leu Leu Ser Glu Asn Arg Lys Met Ile Thr Asn
                 215                 220                 225

 gag aag ata gat gct tac aat gaa gct gca gtc agt att ttg aat agt      836
 Glu Lys Ile Asp Ala Tyr Asn Glu Ala Ala Val Ser Ile Leu Asn Ser
             230                 235                 240

 agc acc aga aat tct aaa tca aat gtt aag atg ttc agt gtt tcc aaa      884
 Ser Thr Arg Asn Ser Lys Ser Asn Val Lys Met Phe Ser Val Ser Lys
         245                 250                 255

 tta att gct caa gaa acc atc atg gaa tct ttg gat ggc tta cat ctt      932
 Leu Ile Ala Gln Glu Thr Ile Met Glu Ser Leu Asp Gly Leu His Leu
     260                 265                 270

 cct gaa tcg agc aga gaa act gtg aga aat ttt tac ata tgt cag tag      980
 Pro Glu Ser Ser Arg Glu Thr Val Arg Asn Phe Tyr Ile Cys Gln 
 275                 280                 285

 atggagacta taatatcaat tgctttaagc cataagtcat tataacatgg ttataaataa   1040

 tttgttttat tgcagtctta gtaacttgta gttattgtgt ataaagatac atctagaaat   1100

 tattttgctt tctatcatct agttgaatat atacgtaaga gttttggtat actccaagag   1160

 agaaagaagt tagggaagag gggaaattaa acttcattta ctgagtgcta atcactgtta   1220

 atatacattg tctctcagaa gcatatatgt tctcagcc                           1258




      <210> 94
      <211> 1213
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (111)..(932)

      <400> 94
 taagcttgcg gccgctcctc gcctggctgc agcggcggca gccccagtgc tgcccctgtg     60

 cggcgcccct ttcccgctcc gccgcgcact gttgtcatgg aggaaccaag   atg gcg     116
                                                          Met Ala
                                                            1

 gct ctg gcc tac aac ctg ggc aag cgg gag atc aac cac tac ttc agc      164
 Ala Leu Ala Tyr Asn Leu Gly Lys Arg Glu Ile Asn His Tyr Phe Ser
           5                  10                  15

 gtg agg agc gcc aag gtg ctg gcg ctg gtg gcc gtg ctg ctg ctc gca      212
 Val Arg Ser Ala Lys Val Leu Ala Leu Val Ala Val Leu Leu Leu Ala
      20                  25                  30

 gcg tgc cac ctc gcc tcc cgc cgc tac cga ggc aat gat tcg tgt gaa      260
 Ala Cys His Leu Ala Ser Arg Arg Tyr Arg Gly Asn Asp Ser Cys Glu
  35                  40                  45                  50

 tac ctt ctc tca agt ggc aga ttt ctt gga gag aaa gtt tgg caa cct      308
 Tyr Leu Leu Ser Ser Gly Arg Phe Leu Gly Glu Lys Val Trp Gln Pro
                  55                  60                  65

 cac agt tgt atg atg cat aaa tac aaa atc agt gaa gca aag aac tgc      356
 His Ser Cys Met Met His Lys Tyr Lys Ile Ser Glu Ala Lys Asn Cys
              70                  75                  80

 ctt gta gat aaa cat att gca ttt att gga gat tcc aga att cgt caa      404
 Leu Val Asp Lys His Ile Ala Phe Ile Gly Asp Ser Arg Ile Arg Gln
          85                  90                  95

 ttg ttt tat tct ttt gta aaa ata att aat ccc caa ttc aaa gaa gaa      452
 Leu Phe Tyr Ser Phe Val Lys Ile Ile Asn Pro Gln Phe Lys Glu Glu
     100                 105                 110

 gga aat aag gat ttt ctg tgg cat cct gaa gtt aat ggt tct atg aaa      500
 Gly Asn Lys Asp Phe Leu Trp His Pro Glu Val Asn Gly Ser Met Lys
 115                 120                 125                 130

 cag tgt atc aaa gtg tgg act gag gat tcc att gca aag cca cat gtg      548
 Gln Cys Ile Lys Val Trp Thr Glu Asp Ser Ile Ala Lys Pro His Val
                 135                 140                 145

 att gta gca gga gct gcc aca tgg tcc atc aag att cac aat ggt agc      596
 Ile Val Ala Gly Ala Ala Thr Trp Ser Ile Lys Ile His Asn Gly Ser
             150                 155                 160

 agt gaa gcg ctt tct caa tat aaa atg aac atc acc tcc ata gca cca      644
 Ser Glu Ala Leu Ser Gln Tyr Lys Met Asn Ile Thr Ser Ile Ala Pro
         165                 170                 175

 ctt tta gaa aaa ttg gca aag act agt gat gtt tat tgg gtc tta caa      692
 Leu Leu Glu Lys Leu Ala Lys Thr Ser Asp Val Tyr Trp Val Leu Gln
     180                 185                 190

 gat cct gtt tat gaa gat cta tta agt gaa aat agg aag atg atc act      740
 Asp Pro Val Tyr Glu Asp Leu Leu Ser Glu Asn Arg Lys Met Ile Thr
 195                 200                 205                 210

 aat gag aag ata gat gct tac aat gaa gct gca gtc agt att ttg aat      788
 Asn Glu Lys Ile Asp Ala Tyr Asn Glu Ala Ala Val Ser Ile Leu Asn
                 215                 220                 225

 agt agc acc aga aat tct aaa tca aat gtt aag atg ttc agt gtt tcc      836
 Ser Ser Thr Arg Asn Ser Lys Ser Asn Val Lys Met Phe Ser Val Ser
             230                 235                 240

 aaa tta att gct caa gaa acc atc atg gaa tct ttg gat ggc tta cat      884
 Lys Leu Ile Ala Gln Glu Thr Ile Met Glu Ser Leu Asp Gly Leu His
         245                 250                 255

 ctt cct gaa tcg agc aga gaa act gtg aga aat ttt tac ata tgt cag      932
 Leu Pro Glu Ser Ser Arg Glu Thr Val Arg Asn Phe Tyr Ile Cys Gln 
     260                 265                 270

 tagatggaga ctataatatc aattgcttta agccataagt cattataaca tggttataaa    992

 taatttgttt tattgcagtc ttagtaactt gtagttattg tgtataaaga tacatctaga   1052

 aattattttg ctttctatca tctagttgaa tatatacgta agagttttgg tatactccaa   1112

 gagagaaaga agttagggaa gaggggaaat taaacttcat ttactgagtg ctaatcactg   1172

 ttaatataca ttgtctctca gaagcatata tgttctcagc c                       1213




      <210> 95
      <211> 1048
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (565)..(1014)

      <220>
      <221> misc_feature
      <222> (1)...(1048)
      <223> n = a,t,c or g

      <400> 95
 attaaaagtt tgacccgntc ggacccaccc gttttccaaa accgggctca gctcggttag     60

 tgggcggggg gaaatttccc agaccctacc ccttgcttta gtcctaaaaa cagtggcaaa    120

 aacagctgtc ggtcgattcc ggaatttcac cccgttcgca aagtaagatg gagaaagctg    180

 cggaagggta ggaagtcagc agccactccg gcataagtag atcccagctt tgggcggtat    240

 tttttgccac atcagttgag gggtaaacca gtccctcgcg gccttgagga gcaggcccag    300

 aaataaagtc ttaaggggtc cggtggcttt ggccctagag tgttatcaac acctcccagc    360

 ccttgggccc tttagaagtg tcccccgtgc tggccgggac acgttccaag ctcgggttag    420

 agggtatttt ccgggacctc gcttttatag cacaacgagg gcagagtcca ttggtctgcg    480

 aaaagaancc gcgctaacta gtttgtctct acggcggcct cgtagtcact gccgcggcgc    540

 cttgagtctc cgggccgcct tgcc   atg gct gcc cgt ggt gtc atc gct cca     591
                              Met Ala Ala Arg Gly Val Ile Ala Pro
                                1               5

 gtt ggc gag agt ttg cgc tac gct gag tac ttg cag ccc tcg gcc aaa      639
 Val Gly Glu Ser Leu Arg Tyr Ala Glu Tyr Leu Gln Pro Ser Ala Lys
  10                  15                  20                  25

 cgg cca gac gcc gac gtc gac cag cag gga ctg gta aga agt ttg ata      687
 Arg Pro Asp Ala Asp Val Asp Gln Gln Gly Leu Val Arg Ser Leu Ile
                  30                  35                  40

 gct gta gga ctg ggt gtt gca gct ctt gca ttt gca ggt cgc tac gca      735
 Ala Val Gly Leu Gly Val Ala Ala Leu Ala Phe Ala Gly Arg Tyr Ala
              45                  50                  55

 ttt cgg atc tgg aaa cct cta gaa caa gtt atc aca gaa act gca aag      783
 Phe Arg Ile Trp Lys Pro Leu Glu Gln Val Ile Thr Glu Thr Ala Lys
          60                  65                  70

 aag att tca act cct agc ttt tca tcc tac tat aaa gga gga ttt gaa      831
 Lys Ile Ser Thr Pro Ser Phe Ser Ser Tyr Tyr Lys Gly Gly Phe Glu
      75                  80                  85

 cag aaa atg agt agg cga gaa gct ggt ctt att tta ggt gta agc cca      879
 Gln Lys Met Ser Arg Arg Glu Ala Gly Leu Ile Leu Gly Val Ser Pro
  90                  95                 100                 105

 tct gct ggc aag gct aag att aga aca gct cat agg aga gtc atg att      927
 Ser Ala Gly Lys Ala Lys Ile Arg Thr Ala His Arg Arg Val Met Ile
                 110                 115                 120

 ttg aat cac cca gat aaa ggt gga tct cct tac gta gca gcc aaa ata      975
 Leu Asn His Pro Asp Lys Gly Gly Ser Pro Tyr Val Ala Ala Lys Ile
             125                 130                 135

 aat gaa gca aaa gac ttg cta gaa aca acc acc aaa cat tgatgcttaa      1024
 Asn Glu Ala Lys Asp Leu Leu Glu Thr Thr Thr Lys His 
         140                 145                 150

 ggaccacact gaaggaaaaa aaaa                                          1048




      <210> 96
      <211> 1233
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1230)

      <400> 96
  atg ggc gag ggg aaa ctt aaa tca tca tcc cgg ggc agc cac ggc ggc      48
  Met Gly Glu Gly Lys Leu Lys Ser Ser Ser Arg Gly Ser His Gly Gly
    1               5                  10                  15

 tcc atg cgt gag gct ggt gcc acg cgg tct ccc ggt gtt ggc att gtc       96
 Ser Met Arg Glu Ala Gly Ala Thr Arg Ser Pro Gly Val Gly Ile Val
              20                  25                  30

 tcc agg cct tct cct cag ttc tgc aca cag cta caa aac aaa aga aca      144
 Ser Arg Pro Ser Pro Gln Phe Cys Thr Gln Leu Gln Asn Lys Arg Thr
          35                  40                  45

 gtt gcc agc act tgg aag agg atg tgg atc caa acc aaa tgg agg aca      192
 Val Ala Ser Thr Trp Lys Arg Met Trp Ile Gln Thr Lys Trp Arg Thr
      50                  55                  60

 gat act ccc tct atg gac aag ata ctc atg gaa gaa gtc aag tta gaa      240
 Asp Thr Pro Ser Met Asp Lys Ile Leu Met Glu Glu Val Lys Leu Glu
  65                  70                  75                  80

 gag cag ctg aag gag gct gtg gaa gaa gat aag caa gca ctg gca gat      288
 Glu Gln Leu Lys Glu Ala Val Glu Glu Asp Lys Gln Ala Leu Ala Asp
                  85                  90                  95

 act gag ggc tca gag cag agc agc caa aaa ttg gtg gag gag gga aat      336
 Thr Glu Gly Ser Glu Gln Ser Ser Gln Lys Leu Val Glu Glu Gly Asn
             100                 105                 110

 atg tat agc att cag ggc ttc tgc aag gac tcg tta gag gtt gca gat      384
 Met Tyr Ser Ile Gln Gly Phe Cys Lys Asp Ser Leu Glu Val Ala Asp
         115                 120                 125

 gtt ttg gag aag gca aca cag tgt gtt cca gaa gaa gaa att aaa gac      432
 Val Leu Glu Lys Ala Thr Gln Cys Val Pro Glu Glu Glu Ile Lys Asp
     130                 135                 140

 aat aac cct cac ctg aag aac ctc tct cta tgg gac cat cta gtt gca      480
 Asn Asn Pro His Leu Lys Asn Leu Ser Leu Trp Asp His Leu Val Ala
 145                 150                 155                 160

 gga aaa gaa ggt caa gac tcc cag tca ttc tac att atg tct atg gaa      528
 Gly Lys Glu Gly Gln Asp Ser Gln Ser Phe Tyr Ile Met Ser Met Glu
                 165                 170                 175

 aaa ctg tct tcc aca aaa ctg gtc cct gct ccc cca aaa att ggg gac      576
 Lys Leu Ser Ser Thr Lys Leu Val Pro Ala Pro Pro Lys Ile Gly Asp
             180                 185                 190

 cgc tgc act caa cac aga gag aaa aac aaa aag ctc aag tct tta cct      624
 Arg Cys Thr Gln His Arg Glu Lys Asn Lys Lys Leu Lys Ser Leu Pro
         195                 200                 205

 ctc agc cct cag cca aga tgt ctc acc cca ctc tct ctg atg caa caa      672
 Leu Ser Pro Gln Pro Arg Cys Leu Thr Pro Leu Ser Leu Met Gln Gln
     210                 215                 220

 gaa gcc cct gga gaa cgt ttc agt ccc att ttg tac ttc tgt cat gtg      720
 Glu Ala Pro Gly Glu Arg Phe Ser Pro Ile Leu Tyr Phe Cys His Val
 225                 230                 235                 240

 ctc atc aca gtc tgg ttg cct gac ctg ctg aga cct gtg ttt gct atc      768
 Leu Ile Thr Val Trp Leu Pro Asp Leu Leu Arg Pro Val Phe Ala Ile
                 245                 250                 255

 cct gca gat ggg tgg cta cca ctt aat gtt gat tgt gat gaa atg cca      816
 Pro Ala Asp Gly Trp Leu Pro Leu Asn Val Asp Cys Asp Glu Met Pro
             260                 265                 270

 gcc gag gca tat gcc att caa gct aag ggt gct aca ctt gac cac tgc      864
 Ala Glu Ala Tyr Ala Ile Gln Ala Lys Gly Ala Thr Leu Asp His Cys
         275                 280                 285

 ggc agt ata gat gag tct gaa gaa tgg tat ggg atg gat act tac gaa      912
 Gly Ser Ile Asp Glu Ser Glu Glu Trp Tyr Gly Met Asp Thr Tyr Glu
     290                 295                 300

 tgc act cga gca ggg gtc tcc atc cac agg gcc aca gag cca gag gtg      960
 Cys Thr Arg Ala Gly Val Ser Ile His Arg Ala Thr Glu Pro Glu Val
 305                 310                 315                 320

 agc agc agg ccc aga act gtt tcc agt ggc cct ctc cag gcc cgg ctc     1008
 Ser Ser Arg Pro Arg Thr Val Ser Ser Gly Pro Leu Gln Ala Arg Leu
                 325                 330                 335

 tcc atc cgg gcc gcg tcc agc ggt ccc aac ccc tgc ctc acg aca acc     1056
 Ser Ile Arg Ala Ala Ser Ser Gly Pro Asn Pro Cys Leu Thr Thr Thr
             340                 345                 350

 acg ttt ggc cca gct cct ggt agc ctt tgt agg ccc cag gct cct cga     1104
 Thr Phe Gly Pro Ala Pro Gly Ser Leu Cys Arg Pro Gln Ala Pro Arg
         355                 360                 365

 aag atc ttg ata ggg gaa gtc ctc ctt gat gct ctg cca aga cat gaa     1152
 Lys Ile Leu Ile Gly Glu Val Leu Leu Asp Ala Leu Pro Arg His Glu
     370                 375                 380

 gta acc ttg ccc tcc tct gga gtc cca cgg tac ttc ctc tgt gtt tgt     1200
 Val Thr Leu Pro Ser Ser Gly Val Pro Arg Tyr Phe Leu Cys Val Cys
 385                 390                 395                 400

 ctt gtg gat tct cag tac ctg act cgt ctt tag                         1233
 Leu Val Asp Ser Gln Tyr Leu Thr Arg Leu 
                 405                 410





      <210> 97
      <211> 3746
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (9)..(2141)

      <400> 97
 ggggcaga atg ctg gat ggc cca ctg ttc tcc gag ggg cct gac agc ccc      50
          Met Leu Asp Gly Pro Leu Phe Ser Glu Gly Pro Asp Ser Pro
            1               5                  10

 cgg gag ctc cag gat gag gag tct ggc agc tgc ctc tgg gtg cag aag       98
 Arg Glu Leu Gln Asp Glu Glu Ser Gly Ser Cys Leu Trp Val Gln Lys
  15                  20                  25                  30

 tcc aag cta ttg gtg ata gaa gtg aag act att tcc tgt cat tat agt      146
 Ser Lys Leu Leu Val Ile Glu Val Lys Thr Ile Ser Cys His Tyr Ser
                  35                  40                  45

 cgc cgc gcc cct tct cga cag ccc atg gac ttc cag gcc agc cac tgg      194
 Arg Arg Ala Pro Ser Arg Gln Pro Met Asp Phe Gln Ala Ser His Trp
              50                  55                  60

 gct cgc ggg ttc cag aac cgc acg tgt ggg ccg cgc ccg gga tcc cca      242
 Ala Arg Gly Phe Gln Asn Arg Thr Cys Gly Pro Arg Pro Gly Ser Pro
          65                  70                  75

 cag ccg ccg ccc cgc cgg ccc tgg gcc tcc agg gtg ctg cag gag gcg      290
 Gln Pro Pro Pro Arg Arg Pro Trp Ala Ser Arg Val Leu Gln Glu Ala
      80                  85                  90

 acc aac tgg cgg gcg ggg ccc ctg gcc gag gtc cga gct cgg gag caa      338
 Thr Asn Trp Arg Ala Gly Pro Leu Ala Glu Val Arg Ala Arg Glu Gln
  95                 100                 105                 110

 gag aaa agg aaa gcg gcg tcg cag gag cgg gag gcc aag gag acc gag      386
 Glu Lys Arg Lys Ala Ala Ser Gln Glu Arg Glu Ala Lys Glu Thr Glu
                 115                 120                 125

 cga aaa agg cgc aag gct ggt ggg gcc cga cgg agc ccc ccg ggt cga      434
 Arg Lys Arg Arg Lys Ala Gly Gly Ala Arg Arg Ser Pro Pro Gly Arg
             130                 135                 140

 ccc cgc ccg gag ccc cgc aac gcc cct cgg gtg gcc cag ctg gca ggg      482
 Pro Arg Pro Glu Pro Arg Asn Ala Pro Arg Val Ala Gln Leu Ala Gly
         145                 150                 155

 ctc cct gct ccc ttg cgg ccg gag cgc ctg gcg cct gtg ggg cga gcg      530
 Leu Pro Ala Pro Leu Arg Pro Glu Arg Leu Ala Pro Val Gly Arg Ala
     160                 165                 170

 ccc cgt cca tcc gcg cag ccg cag agc gac cca ggg tcg gcg tgg gcg      578
 Pro Arg Pro Ser Ala Gln Pro Gln Ser Asp Pro Gly Ser Ala Trp Ala
 175                 180                 185                 190

 ggg ccc tgg gga ggt cgg cgg ccc ggg ccc cca agc tac gag gct cac      626
 Gly Pro Trp Gly Gly Arg Arg Pro Gly Pro Pro Ser Tyr Glu Ala His
                 195                 200                 205

 ctg ctg ctg aga ggt tct gcc ggg acc gcc cca cga cgc cgc tgg gac      674
 Leu Leu Leu Arg Gly Ser Ala Gly Thr Ala Pro Arg Arg Arg Trp Asp
             210                 215                 220

 cgg ccg cca ccc tac gtg gct cca cct tct tac gaa ggc ccc cat agg      722
 Arg Pro Pro Pro Tyr Val Ala Pro Pro Ser Tyr Glu Gly Pro His Arg
         225                 230                 235

 acc ttg ggg act aag aga ggc ccc ggg aac tct cag gtg ccc act tca      770
 Thr Leu Gly Thr Lys Arg Gly Pro Gly Asn Ser Gln Val Pro Thr Ser
     240                 245                 250

 tca gcc cca gct gcg act cca gcc agg aca gac gga ggg cgc aca aag      818
 Ser Ala Pro Ala Ala Thr Pro Ala Arg Thr Asp Gly Gly Arg Thr Lys
 255                 260                 265                 270

 aag agg ctg gat cct cgg atc tac cgg gac gtc ctc ggg gct tgg ggt      866
 Lys Arg Leu Asp Pro Arg Ile Tyr Arg Asp Val Leu Gly Ala Trp Gly
                 275                 280                 285

 ctc cga cag ggg caa ggt ctc ttg ggg gga tcc cca ggc tgt gga gcg      914
 Leu Arg Gln Gly Gln Gly Leu Leu Gly Gly Ser Pro Gly Cys Gly Ala
             290                 295                 300

 gcc aga gca agg cca gag ccc ggc aag ggg gtc gtg gag aaa agc ctg      962
 Ala Arg Ala Arg Pro Glu Pro Gly Lys Gly Val Val Glu Lys Ser Leu
         305                 310                 315

 ggg ctg gct gct gct gac ctg aac agt ggt agc gac agc cat ccc caa     1010
 Gly Leu Ala Ala Ala Asp Leu Asn Ser Gly Ser Asp Ser His Pro Gln
     320                 325                 330

 gcc aaa gct aca ggg agc gca ggc acc gag ata gct cct gcg ggg tct     1058
 Ala Lys Ala Thr Gly Ser Ala Gly Thr Glu Ile Ala Pro Ala Gly Ser
 335                 340                 345                 350

 gca act gcg gct ccc tgt gcc ccg cat ccc gct ccc aga tcc agg cac     1106
 Ala Thr Ala Ala Pro Cys Ala Pro His Pro Ala Pro Arg Ser Arg His
                 355                 360                 365

 cac ctc aag ggc tcg agg gaa ggg aaa gaa gga gaa cag atc tgg ttt     1154
 His Leu Lys Gly Ser Arg Glu Gly Lys Glu Gly Glu Gln Ile Trp Phe
             370                 375                 380

 ccc aaa tgc tgg att ccc tcc cct aaa aag cag ccg ccc cgc cat agc     1202
 Pro Lys Cys Trp Ile Pro Ser Pro Lys Lys Gln Pro Pro Arg His Ser
         385                 390                 395

 cag aca ctc ccc aga ccc tgg gct ccc gga ggc acc gga tgg aga gaa     1250
 Gln Thr Leu Pro Arg Pro Trp Ala Pro Gly Gly Thr Gly Trp Arg Glu
     400                 405                 410

 tct ctg ggt ctt gga gag ggg gca gga ccg gag acc ctg gag ggt tgg     1298
 Ser Leu Gly Leu Gly Glu Gly Ala Gly Pro Glu Thr Leu Glu Gly Trp
 415                 420                 425                 430

 aag gcg acc cgc cgt gcc cac acc ttg ccc cgc agt tcc cag ggc ctg     1346
 Lys Ala Thr Arg Arg Ala His Thr Leu Pro Arg Ser Ser Gln Gly Leu
                 435                 440                 445

 tcc cgt ggg gaa ggc gtc ttt gtc att gac gcc acg tgc gta gtg ata     1394
 Ser Arg Gly Glu Gly Val Phe Val Ile Asp Ala Thr Cys Val Val Ile
             450                 455                 460

 cga tcc caa tat gtt cca acc ccc cga acc cag cag gtg cag ctt ttg     1442
 Arg Ser Gln Tyr Val Pro Thr Pro Arg Thr Gln Gln Val Gln Leu Leu
         465                 470                 475

 ccc tct ggg gtg aca cgc gtg gtg ggg gat tcc ccc agc caa tcg aag     1490
 Pro Ser Gly Val Thr Arg Val Val Gly Asp Ser Pro Ser Gln Ser Lys
     480                 485                 490

 ccc ggc aag gag gag ggt gaa ggg gcc acg gtc ttt cct tcc cct tgt     1538
 Pro Gly Lys Glu Glu Gly Glu Gly Ala Thr Val Phe Pro Ser Pro Cys
 495                 500                 505                 510

 caa aag cgg ctg tcg agc agt cgc ctt tta cac cag ccc ggc ggg ggc     1586
 Gln Lys Arg Leu Ser Ser Ser Arg Leu Leu His Gln Pro Gly Gly Gly
                 515                 520                 525

 cgc ggg ggc gaa gct gag ggc ggg agg ccg ggg gac tcc aca ctg gag     1634
 Arg Gly Gly Glu Ala Glu Gly Gly Arg Pro Gly Asp Ser Thr Leu Glu
             530                 535                 540

 gag cgc act ttc cgc atc ttg ggg ctc ccg gcc ccc gaa gta aac ctg     1682
 Glu Arg Thr Phe Arg Ile Leu Gly Leu Pro Ala Pro Glu Val Asn Leu
         545                 550                 555

 cgg gac gcc ccc acg cag cca ggt agc cca gag cac caa gcc tta ggc     1730
 Arg Asp Ala Pro Thr Gln Pro Gly Ser Pro Glu His Gln Ala Leu Gly
     560                 565                 570

 cca gca gct tcg gga gcc cag ggc aga gcc gag ggg tcg gaa gtg gcg     1778
 Pro Ala Ala Ser Gly Ala Gln Gly Arg Ala Glu Gly Ser Glu Val Ala
 575                 580                 585                 590

 gtg gtc cag cgg cgc gcc ggc cgg ggc tgg gcg cgg acc cca ggg ccc     1826
 Val Val Gln Arg Arg Ala Gly Arg Gly Trp Ala Arg Thr Pro Gly Pro
                 595                 600                 605

 tac gcc ggg gcc ctg cga gaa gcc gtg tcc cgt atc cgc cgc cac aca     1874
 Tyr Ala Gly Ala Leu Arg Glu Ala Val Ser Arg Ile Arg Arg His Thr
             610                 615                 620

 gcc cct gac tcg gac acg gac gaa gct gag gag ctc agc gtc cat agc     1922
 Ala Pro Asp Ser Asp Thr Asp Glu Ala Glu Glu Leu Ser Val His Ser
         625                 630                 635

 ggc tcc tct gat gga agc gac aca gaa gcc ccg ggc gcc tcc tgg cgg     1970
 Gly Ser Ser Asp Gly Ser Asp Thr Glu Ala Pro Gly Ala Ser Trp Arg
     640                 645                 650

 aat gag agg acc ctg ccc gag gtt gga aac agt tcg cca gag gaa gat     2018
 Asn Glu Arg Thr Leu Pro Glu Val Gly Asn Ser Ser Pro Glu Glu Asp
 655                 660                 665                 670

 ggg aag aca gcg gaa ctg agc gac agt gtc ggg gag atc cta gat gtc     2066
 Gly Lys Thr Ala Glu Leu Ser Asp Ser Val Gly Glu Ile Leu Asp Val
                 675                 680                 685

 ata agc caa acc gag gag gtc ctc ttc ggg gtg agg gac atc aga ggg     2114
 Ile Ser Gln Thr Glu Glu Val Leu Phe Gly Val Arg Asp Ile Arg Gly
             690                 695                 700

 acc caa cag gga aat agg aag agg cag tgaga ggccccttct tgtatttgtg     2166
 Thr Gln Gln Gly Asn Arg Lys Arg Gln 
         705                 710

 tccccaacgc atccatcctt gggtccactg gtccccattc ttccccacag acttcctttg   2226

 cttctctttt ccttgtatct ttacccatac ctgttctcat ccttgaaata taaatgaaag   2286

 gaagggaagc atatgcccat taatgatttt gtttcaggag aggtgagaat gagcagattt   2346

 aattaatgtc tgttatgttc agggcacaag ggtgagctct tcgcaggggc tgatgcactg   2406

 ggtgtggagc tgagcagaga ggcctaacca ggatcaggca ggagggcagg gatggtggca   2466

 gccataggag ggcagggtag ggtagggcct ctgaggagga gggaaaaagt gaaggagagg   2526

 ctttggacct ggtgacagag tgatcagatg acagaggggt tcttgggaga agaggcatag   2586

 gtccagcaac aaccaacaaa gcagaaggag ggctcacctt ggtgtcacaa gtcttggatt   2646

 tcaatcccaa ctctgccact gagttgctgg ttgactgagg ccagtcactt tccctctcca   2706

 ggcctccagg cctcctggta tataaaatga tggtattcta aggtccatcc ttccgtctct   2766

 gacattttga gatctttgga aaggactcta tctcatcctc ccctcgacaa gccaagaatg   2826

 agaattggga ataagtgaac agagtttgag ggtttctggg cggcctccgt gtcacccaaa   2886

 gtcatgatca attcaggaga ctgcccaagg cttgcagaag aggtaaggga gtgaggcact   2946

 cctatcccag tctcccaggt ttggttgagg gctccccaag gcagggcaag atagcggccc   3006

 tgtcactgac cctggcctgt ggtggtctga gctggggagg gaaggacacc aatgaatcag   3066

 cttgggacct ctttaggcct tccccttttc ctccaccccg atgctcctta gtgatgctct   3126

 gaggcgtggc cacgatctcc ctcccaggtg gtatcgccca cctgaaaaaa tcctgagaat   3186

 ttctcccatc ttggcctctt ccagaaaccg gccaggcaag gaaagaggcc ggtcaccaga   3246

 agccagcagg cgtggggtgt gatactctct atagccacta cagggcgcgc gcaggtcgcg   3306

 gatctcccca gttgctaatc ccggctctgc cactcaatcc tatccctagt tcccgagcgc   3366

 gggtcccccg ccttgcagtc tccagccgtg cggggccggg agcaggcctc cggcctccca   3426

 gacttctaga gcccgccggg cccatctttg tactcatcca ccccagccgg cttgggactc   3486

 agacaccgaa gtcttttttt ttttctctcc gatccttgga cacctcctct gtctgccatt   3546

 tattagccat gtgaacttgg ccacatcact tcacctccct gagcctcagt ttcctcatct   3606

 gtcaaatggg ggtttataaa cacctacctc gcagggttgt tgtgaggatt taatgcgata   3666

 atgtatgtaa agcgccttgc acactgcctg gcacacagta ggcgctcaat aaatctaagc   3726

 ttccctttaa aaaaaaaaaa                                               3746




      <210> 98
      <211> 986
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (327)..(929)

      <400> 98
 atgcctttcc ctttcgctcc tgctccaggc tccgcctccg ccgtgtccgg gctgctcgcc     60

 ccgcccccgc tcgccccgcc cccgctcgcc ccgcccccgc tcgccccgcc cccgctcgcc    120

 ccgcccccgc tcgccccgcc cccgctcgcc ccgcccccgc tcgccccgcc cctggatttg    180

 ctccctcaaa gcggaggtga ggccggactg aggctcttac agtggtccct gctggccctt    240

 ggtgacgggt cgcgtcagtt ccgacccgga cccgtacgct gctgcgctga cgtggctcct    300

 ggaagcaggg ctggcgtagg gccgcc atg ttg cag cag gat agt aat gat gac     353
                              Met Leu Gln Gln Asp Ser Asn Asp Asp
                                1               5

 act gaa gat gtt tca ctg ttt gat gcg gaa gag gag acg act aat aga      401
 Thr Glu Asp Val Ser Leu Phe Asp Ala Glu Glu Glu Thr Thr Asn Arg
  10                  15                  20                  25

 cca aga aaa gcc aaa atc aga cat cca gta gca tcg ttt ttc cac tta      449
 Pro Arg Lys Ala Lys Ile Arg His Pro Val Ala Ser Phe Phe His Leu
                  30                  35                  40

 ttc ttt cga gtc agt gca atc atc gtc tgt ctt ctc tgt gag ttg ctc      497
 Phe Phe Arg Val Ser Ala Ile Ile Val Cys Leu Leu Cys Glu Leu Leu
              45                  50                  55

 agc agc agc ttt att acc tgt atg gtt aca att atc ttg ttg ttg tcg      545
 Ser Ser Ser Phe Ile Thr Cys Met Val Thr Ile Ile Leu Leu Leu Ser
          60                  65                  70

 tgt gac ttt tgg gca gtg aag aat gtc aca ggt aga cta atg gtt ggc      593
 Cys Asp Phe Trp Ala Val Lys Asn Val Thr Gly Arg Leu Met Val Gly
      75                  80                  85

 cta cgt tgg tgg aat cac att gat gaa gat gga aag agc cat tgg gtg      641
 Leu Arg Trp Trp Asn His Ile Asp Glu Asp Gly Lys Ser His Trp Val
  90                  95                 100                 105

 ttt gaa tct aga aag gag tcc tct caa gag aat aaa act gtg tca gag      689
 Phe Glu Ser Arg Lys Glu Ser Ser Gln Glu Asn Lys Thr Val Ser Glu
                 110                 115                 120

 gct gaa tca aga atc ttt tgg ttg gga ctt att gcc tgt tca gta ctg      737
 Ala Glu Ser Arg Ile Phe Trp Leu Gly Leu Ile Ala Cys Ser Val Leu
             125                 130                 135

 tgg gtg ata ttt gcc ttt agt gca ctc ttc tcc ttc aca gta aag tgg      785
 Trp Val Ile Phe Ala Phe Ser Ala Leu Phe Ser Phe Thr Val Lys Trp
         140                 145                 150

 ctg gcg gtg gtt att atg ggt gtg gtg cta caa ggt gcc aac ctg tat      833
 Leu Ala Val Val Ile Met Gly Val Val Leu Gln Gly Ala Asn Leu Tyr
     155                 160                 165

 ggt tac atc agg tgt aag gtg cgc agc aga aag cat tta acc agc atg      881
 Gly Tyr Ile Arg Cys Lys Val Arg Ser Arg Lys His Leu Thr Ser Met
 170                 175                 180                 185

 gct act tca tat ttt gga aag cag ttt tta aga caa aac acg tgg aga      929
 Ala Thr Ser Tyr Phe Gly Lys Gln Phe Leu Arg Gln Asn Thr Trp Arg 
                 190                 195                 200

 tgatcagact tcctgaatag agaaagctta tgtgctttgt tacattgggg aacaact       986




      <210> 99
      <211> 1250
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (621)..(1193)

      <400> 99
 ggaacttgct aatctctttt gtcacattcg gattgctcct gctgccccac acacactaac     60

 ccaaccatct tggggtggac tccctgccag cccaactgtt gtattttcag ttcttccagt    120

 gtgaatcagt taatattctc gggaacgagg gagaggttga tcctatgagg aaatcaacca    180

 cagtgaaaag gcttgggccg cttttgtttt cacctgcttt tgttgaacaa atttgatttc    240

 cggagtcagt cattttactg tcaagacatt tcttcggcat tctgcaacag tttccaacat    300

 ggctagatcc atcagaaact gaagccgtgg agaacgctct cggggccttt gccacttctt    360

 ggagtagaag ccgacagaga gctgtttgga aacttctcct tcacacacca gttgaagact    420

 aggctttgga ggttttcaaa gcagacggtg cttggatggg cagggagaag taacattctg    480

 caaatcgccg tcagaggtcc tgaggacaca gacctacctg gcttgcattc cccttgctga    540

 atggcgtgtg ctgcagctgc ccactgaggg ctcttttccc tgggattctg gacttcagag    600

 taggacagca ggctgggaag    atg ctg agt tcc atc aag tgc gtg ttg gtg     650
                          Met Leu Ser Ser Ile Lys Cys Val Leu Val
                            1               5                  10

 ggc gac tct gct gtg ggg aaa acc tct ctg ttg gtg cgc ttc acc tcc      698
 Gly Asp Ser Ala Val Gly Lys Thr Ser Leu Leu Val Arg Phe Thr Ser
                  15                  20                  25

 gag acc ttc ccg gag gcc tac aag ccc aca gtg tac gag aac aca ggg      746
 Glu Thr Phe Pro Glu Ala Tyr Lys Pro Thr Val Tyr Glu Asn Thr Gly
              30                  35                  40

 gtg gac gtc ttc atg gat ggc atc cag atc agc ctg ggc ctc tgg gac      794
 Val Asp Val Phe Met Asp Gly Ile Gln Ile Ser Leu Gly Leu Trp Asp
          45                  50                  55

 aca gcc ggc aat gac gcc ttc aga agc atc cgg ccc ctg tcc tac cag      842
 Thr Ala Gly Asn Asp Ala Phe Arg Ser Ile Arg Pro Leu Ser Tyr Gln
      60                  65                  70

 cag gca gac gtg gtg ctg atg tgc tac tct gtg gcc aac cat aac tca      890
 Gln Ala Asp Val Val Leu Met Cys Tyr Ser Val Ala Asn His Asn Ser
  75                  80                  85                  90

 ttc ctg aac ttg aag aac aag tgg att ggt gaa att agg agc aac ttg      938
 Phe Leu Asn Leu Lys Asn Lys Trp Ile Gly Glu Ile Arg Ser Asn Leu
                  95                 100                 105

 ccc tgt acc cct gtg ctg gtg gtg gcc acc cag act gac cag cgg gag      986
 Pro Cys Thr Pro Val Leu Val Val Ala Thr Gln Thr Asp Gln Arg Glu
             110                 115                 120

 atg ggg ccc cac agg gcc tcc tgc gtc aat gcc atg gaa ggg aag aaa     1034
 Met Gly Pro His Arg Ala Ser Cys Val Asn Ala Met Glu Gly Lys Lys
         125                 130                 135

 ctg gcc cag gat gtc aga gcc aag ggc tac ctg gag tgc tca gcc ctt     1082
 Leu Ala Gln Asp Val Arg Ala Lys Gly Tyr Leu Glu Cys Ser Ala Leu
     140                 145                 150

 agc aat cgg gga gta cag cag gtg ttt gag tgc gcc gtc cga act gcc     1130
 Ser Asn Arg Gly Val Gln Gln Val Phe Glu Cys Ala Val Arg Thr Ala
 155                 160                 165                 170

 gtc aac cag gcc agg aga cga aac aga agg agg ctc ttc tcc atc aat     1178
 Val Asn Gln Ala Arg Arg Arg Asn Arg Arg Arg Leu Phe Ser Ile Asn
                 175                 180                 185

 gag tgc aag atc ttc taaaccccaa gagacttcac acaacactta tgtatgcacc     1233
 Glu Cys Lys Ile Phe 
             190

 ccaaagacta atgggga                                                  1250




      <210> 100
      <211> 1398
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (114)..(1352)

      <400> 100
 tttcgtgcgc cgaccaaggg tccattggtt gccatagaga tcgtcgagcg ctgggcctgt     60

 gatcgctgag gggcgagcag ttgcgaccct gggctcctgg ggacctgagc gtt   atg     116
                                                              Met
                                                                1

 tct ttc cgc gac ctc cgc aat ttc aca gag atg atg aga gcc ctg gga      164
 Ser Phe Arg Asp Leu Arg Asn Phe Thr Glu Met Met Arg Ala Leu Gly
               5                  10                  15

 tac cct cga cat att tct atg gaa aat ttc cgt aca ccc aat ttt gga      212
 Tyr Pro Arg His Ile Ser Met Glu Asn Phe Arg Thr Pro Asn Phe Gly
          20                  25                  30

 ctt gta tct gaa gtg ctt ctc tgg ctt gtg aaa aga tat gag ccc cag      260
 Leu Val Ser Glu Val Leu Leu Trp Leu Val Lys Arg Tyr Glu Pro Gln
      35                  40                  45

 act gac atc ccg cct gac gtg gat act gaa cag gac cga gtt ttc ttc      308
 Thr Asp Ile Pro Pro Asp Val Asp Thr Glu Gln Asp Arg Val Phe Phe
  50                  55                  60                  65

 att aag gca att gcc cag ttc atg gcc acc aag gca cat ata aaa ctc      356
 Ile Lys Ala Ile Ala Gln Phe Met Ala Thr Lys Ala His Ile Lys Leu
                  70                  75                  80

 aac act aag aag ctt tat caa gca gat ggg tat gcg gta aaa gag ctg      404
 Asn Thr Lys Lys Leu Tyr Gln Ala Asp Gly Tyr Ala Val Lys Glu Leu
              85                  90                  95

 ctg aag atc aca tct gtc ctt tat aat gct atg aag acc aag ggg atg      452
 Leu Lys Ile Thr Ser Val Leu Tyr Asn Ala Met Lys Thr Lys Gly Met
         100                 105                 110

 gag ggc tct gaa ata gta gag gaa gat gtc aac aag ttc aag ttt gat      500
 Glu Gly Ser Glu Ile Val Glu Glu Asp Val Asn Lys Phe Lys Phe Asp
     115                 120                 125

 ctt ggc tca aag att gca gat ttg aag gca gcc agg cag ctt gcg tct      548
 Leu Gly Ser Lys Ile Ala Asp Leu Lys Ala Ala Arg Gln Leu Ala Ser
 130                 135                 140                 145

 gaa atc acc tcc aaa gga gca tct ctg tat gac ttg ctc ggc atg gaa      596
 Glu Ile Thr Ser Lys Gly Ala Ser Leu Tyr Asp Leu Leu Gly Met Glu
                 150                 155                 160

 gta gag ttg agg gaa atg aga aca gaa gcc att gcc aga cct ctg gaa      644
 Val Glu Leu Arg Glu Met Arg Thr Glu Ala Ile Ala Arg Pro Leu Glu
             165                 170                 175

 ata aac gag act gaa aaa gtg atg aga att gca ata aaa gag att ttg      692
 Ile Asn Glu Thr Glu Lys Val Met Arg Ile Ala Ile Lys Glu Ile Leu
         180                 185                 190

 aca cag gtt cag aag act aaa gac ctg ctc aat aat gtg gcc tct gat      740
 Thr Gln Val Gln Lys Thr Lys Asp Leu Leu Asn Asn Val Ala Ser Asp
     195                 200                 205

 gaa gct aat tta gaa gcc aaa atc gaa aag aga aaa tta gaa ctg gaa      788
 Glu Ala Asn Leu Glu Ala Lys Ile Glu Lys Arg Lys Leu Glu Leu Glu
 210                 215                 220                 225

 aga aat cgg aag cga cta gag act ctg cag agt gtc agg cca tgt ttt      836
 Arg Asn Arg Lys Arg Leu Glu Thr Leu Gln Ser Val Arg Pro Cys Phe
                 230                 235                 240

 atg gat gag tat gag aag act gag gaa gaa tta caa aag cag tat gac      884
 Met Asp Glu Tyr Glu Lys Thr Glu Glu Glu Leu Gln Lys Gln Tyr Asp
             245                 250                 255

 act tat ctg gag aaa ttt caa aat ctg act tat ctg gaa caa cag ctt      932
 Thr Tyr Leu Glu Lys Phe Gln Asn Leu Thr Tyr Leu Glu Gln Gln Leu
         260                 265                 270

 gaa gac cat cat agg atg gag caa gaa agg ttt gag gaa gct aaa aac      980
 Glu Asp His His Arg Met Glu Gln Glu Arg Phe Glu Glu Ala Lys Asn
     275                 280                 285

 act ctc tgc ctg ata cag aac aag ctc aag gag gaa gag aag cgc ctg     1028
 Thr Leu Cys Leu Ile Gln Asn Lys Leu Lys Glu Glu Glu Lys Arg Leu
 290                 295                 300                 305

 ctc aag agt gga agt aac gat gac tcg gac ata gac atc cag gag gac     1076
 Leu Lys Ser Gly Ser Asn Asp Asp Ser Asp Ile Asp Ile Gln Glu Asp
                 310                 315                 320

 gat gaa tcc gac agt gag ttg gaa gaa agg cgg ctg ccc aag cca cag     1124
 Asp Glu Ser Asp Ser Glu Leu Glu Glu Arg Arg Leu Pro Lys Pro Gln
             325                 330                 335

 aca gcc atg gag atg ctc atg caa gga aga cct ggc aaa cgc att gtg     1172
 Thr Ala Met Glu Met Leu Met Gln Gly Arg Pro Gly Lys Arg Ile Val
         340                 345                 350

 ggc acg atg caa ggt gga gac tcc gat gac aat gag gac tcg gag gag     1220
 Gly Thr Met Gln Gly Gly Asp Ser Asp Asp Asn Glu Asp Ser Glu Glu
     355                 360                 365

 agt gaa att gac atg gaa gat gat gat gac gag gat gac gat ttg gaa     1268
 Ser Glu Ile Asp Met Glu Asp Asp Asp Asp Glu Asp Asp Asp Leu Glu
 370                 375                 380                 385

 gac gag agc att tct ctc tca cca acc aag ccc aat cga agg gtc cgg     1316
 Asp Glu Ser Ile Ser Leu Ser Pro Thr Lys Pro Asn Arg Arg Val Arg
                 390                 395                 400

 aaa tct gaa ccc ctg gat gag agt gac aat gac ttc tgac ccttttgcca     1366
 Lys Ser Glu Pro Leu Asp Glu Ser Asp Asn Asp Phe 
             405                 410

 agggaccctg gcagattaaa accctcagac tt                                 1398




      <210> 101
      <211> 1648
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1272)

      <400> 101
  atg gag gca gct cag tca tct tct acg gcc tca tct gca tgt ata cac      48
  Met Glu Ala Ala Gln Ser Ser Ser Thr Ala Ser Ser Ala Cys Ile His
    1               5                  10                  15

 tgt ggt gga tgc tac ggg cgc tcc ctc aaa aag tac tcg ttt gag tcg       96
 Cys Gly Gly Cys Tyr Gly Arg Ser Leu Lys Lys Tyr Ser Phe Glu Ser
              20                  25                  30

 atc cgt gag gag agc agc tac agc gac atc ccc gac gtc aag aac gac      144
 Ile Arg Glu Glu Ser Ser Tyr Ser Asp Ile Pro Asp Val Lys Asn Asp
          35                  40                  45

 ttc gcc ttc atg ctg cac ctc att gac caa tac gac ccg ctc tac tcc      192
 Phe Ala Phe Met Leu His Leu Ile Asp Gln Tyr Asp Pro Leu Tyr Ser
      50                  55                  60

 aag cgc ttc gcc gtc ttc ctg tcg gag gtg agt gag aac aag ctg cgg      240
 Lys Arg Phe Ala Val Phe Leu Ser Glu Val Ser Glu Asn Lys Leu Arg
  65                  70                  75                  80

 cag ctg aac ctc aac aac gag tgg acg ctg gac aag ctc cgg cag cgg      288
 Gln Leu Asn Leu Asn Asn Glu Trp Thr Leu Asp Lys Leu Arg Gln Arg
                  85                  90                  95

 ctc acc aag aac gcg cag gac aag ctg gag ctg cac ctg ttc atg ctc      336
 Leu Thr Lys Asn Ala Gln Asp Lys Leu Glu Leu His Leu Phe Met Leu
             100                 105                 110

 agt ggc atc cct gac act gtg ttt gac ctg gtg gag ctg gag gtc ctc      384
 Ser Gly Ile Pro Asp Thr Val Phe Asp Leu Val Glu Leu Glu Val Leu
         115                 120                 125

 aag ctg gag ctg atc ccc gac gtg acc atc ccg ccc agc att gcc cag      432
 Lys Leu Glu Leu Ile Pro Asp Val Thr Ile Pro Pro Ser Ile Ala Gln
     130                 135                 140

 ctc acg ggc ctc aag gag ctg tgg ctc tac cac aca gcg gcc aag att      480
 Leu Thr Gly Leu Lys Glu Leu Trp Leu Tyr His Thr Ala Ala Lys Ile
 145                 150                 155                 160

 gaa gcg ccc gcg ctg gcc ttc ctg cgc gag aac ctg cgg gcg ctg cac      528
 Glu Ala Pro Ala Leu Ala Phe Leu Arg Glu Asn Leu Arg Ala Leu His
                 165                 170                 175

 atc aag ttc acc gac atc aag gag atc ccg ctg tgg atc tat agc ctg      576
 Ile Lys Phe Thr Asp Ile Lys Glu Ile Pro Leu Trp Ile Tyr Ser Leu
             180                 185                 190

 aag aca ctg gag gag ctg cac ctg acg ggc aac ctg agc gcg gag aac      624
 Lys Thr Leu Glu Glu Leu His Leu Thr Gly Asn Leu Ser Ala Glu Asn
         195                 200                 205

 aac cgc tac atc gtc atc gac ggg ctg cgg gag ctc aaa cgc ctc aag      672
 Asn Arg Tyr Ile Val Ile Asp Gly Leu Arg Glu Leu Lys Arg Leu Lys
     210                 215                 220

 gtg ctg cgg ctc aag agc aac cta agc aag ctg cca cag gtg gtc aca      720
 Val Leu Arg Leu Lys Ser Asn Leu Ser Lys Leu Pro Gln Val Val Thr
 225                 230                 235                 240

 gat gtg ggc gtg cac ctg cag aag ctg tcc atc aac aat gag ggc acc      768
 Asp Val Gly Val His Leu Gln Lys Leu Ser Ile Asn Asn Glu Gly Thr
                 245                 250                 255

 aag ctc atc ctg tgg tac aac cac atc gcc tac atc ccc atc cag atc      816
 Lys Leu Ile Leu Trp Tyr Asn His Ile Ala Tyr Ile Pro Ile Gln Ile
             260                 265                 270

 ggc aac ctc acc aac ctg gag cgc ctc tac ctg aac cgc aac aag atc      864
 Gly Asn Leu Thr Asn Leu Glu Arg Leu Tyr Leu Asn Arg Asn Lys Ile
         275                 280                 285

 gag aag atc ccc acc cag ctc ttc tac tgc cgc aag ctg cgc tac ctg      912
 Glu Lys Ile Pro Thr Gln Leu Phe Tyr Cys Arg Lys Leu Arg Tyr Leu
     290                 295                 300

 gac ctc agc cac aac aac ctg acc ttc ctc cct gcc gac atc ggc ctc      960
 Asp Leu Ser His Asn Asn Leu Thr Phe Leu Pro Ala Asp Ile Gly Leu
 305                 310                 315                 320

 ctg cag aac ctc cag aac cta gcc atc acg gcc aac cgg atc gag acg     1008
 Leu Gln Asn Leu Gln Asn Leu Ala Ile Thr Ala Asn Arg Ile Glu Thr
                 325                 330                 335

 ctc cct ccg gag ctc ttc cag tgc cgg aag ctg cgg gcc ctg cac ctg     1056
 Leu Pro Pro Glu Leu Phe Gln Cys Arg Lys Leu Arg Ala Leu His Leu
             340                 345                 350

 ggc aac aac gtg ctg cag tca ctg ccc tcc agg gtg ggc gag ctg acc     1104
 Gly Asn Asn Val Leu Gln Ser Leu Pro Ser Arg Val Gly Glu Leu Thr
         355                 360                 365

 aac ctg acg cag atc gag ctg cgg ggc aac cgg ctg gag tgc ctg cct     1152
 Asn Leu Thr Gln Ile Glu Leu Arg Gly Asn Arg Leu Glu Cys Leu Pro
     370                 375                 380

 gtg gag ctg ggc gag tgc cca ctg ctc aag cgc agc ggc ttg gtg gtg     1200
 Val Glu Leu Gly Glu Cys Pro Leu Leu Lys Arg Ser Gly Leu Val Val
 385                 390                 395                 400

 gag gag gac ctg ttc aac aca ctg cca ccc gag gtg aag gag cgg ctg     1248
 Glu Glu Asp Leu Phe Asn Thr Leu Pro Pro Glu Val Lys Glu Arg Leu
                 405                 410                 415

 tgg agg gct gac aag gag cag gcc tgagcgaggc cggcccagca cagcaagcag    1302
 Trp Arg Ala Asp Lys Glu Gln Ala 
             420

 caggaccgct gcccagtcct caggcccgga ggggcaggcc tagcttctcc cagaactccc   1362

 ggacagccag gacagcctcg tggctgggca ggagcctggg gccgcttgtg agtcaggcca   1422

 aagcgagagg acagtatctg tggggctggc cccttttctc cctctgagac tcacgtcccc   1482

 cagggcaagt gcttgtggag gagagcaagt ctcaagagcg cagtatttgg ataatcaggg   1542

 tctcctccct ggaggccagc tctgccccag gggctgagct gccaccagag gtcctgggac   1602

 cctcacttta gttcttggca tttatttgtc tccatctgcc acctgc                  1648




      <210> 102
      <211> 2250
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (487)..(1686)

      <400> 102
 agtcctctcg gcctctgtgc gctcagttgt ttacctaggc gtccggggga ggcacactcg     60

 cgggactcgc gggactcggc cccggcctcc cagctcgccc aggacacgac gctggttctg    120

 cgggctctcg gagcccagcg cgaatccccc gggctaattc ccaagaaccg agaggcagca    180

 ctgcctggag gctgcccccg cctccgcgcc cccgtcctca ctttctgagg ctgttagcag    240

 agagtcccgc gggccgggga gaagcgggac gcgggggatg gcctcgcagc gccctgtgag    300

 cgtcggcagt agtcaggcag ccaggcctcc ttgggcgatc gccctgggta gaggagagga    360

 gtttccgggg ctcgggtccg ggtcgccttc caggggaacg agcgcggaag caagtgggcg    420

 gcgagaggcg gagcaagaga cgctggaggg cgtggacgca gcgggctttg gaaaggcccc    480

 aagtta   atg agg cgt gcg ccg gct gcc gag cgc ctc ttg gag ctg ggc     528
          Met Arg Arg Ala Pro Ala Ala Glu Arg Leu Leu Glu Leu Gly
            1               5                  10

 ttt ccc ccg cgg tgc ggg cgc cag gag ccg cct ttt ccg ctg ggt gtc      576
 Phe Pro Pro Arg Cys Gly Arg Gln Glu Pro Pro Phe Pro Leu Gly Val
  15                  20                  25                  30

 act cgg ggg tgg gga aga tgg ccc att caa aag cgc cgc gag ggg gcc      624
 Thr Arg Gly Trp Gly Arg Trp Pro Ile Gln Lys Arg Arg Glu Gly Ala
                  35                  40                  45

 cgg cca gtg ccc ttc agt gag cgc tcg caa gag gac ggc aga ggc ccg      672
 Arg Pro Val Pro Phe Ser Glu Arg Ser Gln Glu Asp Gly Arg Gly Pro
              50                  55                  60

 gca gct cgg agc tcc ggg acc ttg tgg cgc atc agg acg cgg ctg tcc      720
 Ala Ala Arg Ser Ser Gly Thr Leu Trp Arg Ile Arg Thr Arg Leu Ser
          65                  70                  75

 ctc tgc cgg gac cca gag ccg ccg ccg ccg ctc tgc ctc ctg cgt gtt      768
 Leu Cys Arg Asp Pro Glu Pro Pro Pro Pro Leu Cys Leu Leu Arg Val
      80                  85                  90

 agc ctc ctc tgc gcg ctc cgg gca ggc ggc cgt ggg agc cgc tgg ggc      816
 Ser Leu Leu Cys Ala Leu Arg Ala Gly Gly Arg Gly Ser Arg Trp Gly
  95                 100                 105                 110

 gag gac ggc gcg agg ctg ctg ctg ctg ccc ccg gcc cgc gcg gct gga      864
 Glu Asp Gly Ala Arg Leu Leu Leu Leu Pro Pro Ala Arg Ala Ala Gly
                 115                 120                 125

 aac gga gag gcc gag cca agc ggc ggc ccc tct tat gct ggg agg atg      912
 Asn Gly Glu Ala Glu Pro Ser Gly Gly Pro Ser Tyr Ala Gly Arg Met
             130                 135                 140

 ctg gag agt agc ggc tgc aaa gcg ctg aag gag ggc gtg ctg gag aag      960
 Leu Glu Ser Ser Gly Cys Lys Ala Leu Lys Glu Gly Val Leu Glu Lys
         145                 150                 155

 cgc agc gac ggg ttg ttg cag ctc tgg aag aaa aag tgt tgc atc ctc     1008
 Arg Ser Asp Gly Leu Leu Gln Leu Trp Lys Lys Lys Cys Cys Ile Leu
     160                 165                 170

 acc gag gaa ggg ctg ctg ctt atc ccg ccc aag cag ctg caa cac cag     1056
 Thr Glu Glu Gly Leu Leu Leu Ile Pro Pro Lys Gln Leu Gln His Gln
 175                 180                 185                 190

 cag cag cag caa cag cag cag cag cag cag caa caa cag ccc ggg cag     1104
 Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Gly Gln
                 195                 200                 205

 ggg ccg gcc gag ccg tcc caa ccc agt ggc ccc gct gtc gcc agc ctc     1152
 Gly Pro Ala Glu Pro Ser Gln Pro Ser Gly Pro Ala Val Ala Ser Leu
             210                 215                 220

 gag ccg ccg gtc aag ctc aag gaa ctg cac ttc tcc aac atg aag acc     1200
 Glu Pro Pro Val Lys Leu Lys Glu Leu His Phe Ser Asn Met Lys Thr
         225                 230                 235

 gtg gac tgt gtg gag cgc aag ggc aag tac atg tac ttc act gtg gtg     1248
 Val Asp Cys Val Glu Arg Lys Gly Lys Tyr Met Tyr Phe Thr Val Val
     240                 245                 250

 atg gca gag ggc aag gag atc gac ttt cgg tgc ccg caa gac cag ggc     1296
 Met Ala Glu Gly Lys Glu Ile Asp Phe Arg Cys Pro Gln Asp Gln Gly
 255                 260                 265                 270

 tgg aac gcc gag atc acg ctg cag atg gtg cag tac aag aat cgt cag     1344
 Trp Asn Ala Glu Ile Thr Leu Gln Met Val Gln Tyr Lys Asn Arg Gln
                 275                 280                 285

 gcc atc ctg gcg gtc aaa tcc acg cgg cag aag cag cag cac ctg gtc     1392
 Ala Ile Leu Ala Val Lys Ser Thr Arg Gln Lys Gln Gln His Leu Val
             290                 295                 300

 cag cag cag ccc ccc tcg cag ccg cag ccg cag ccg cag ctc cag ccc     1440
 Gln Gln Gln Pro Pro Ser Gln Pro Gln Pro Gln Pro Gln Leu Gln Pro
         305                 310                 315

 caa ccc cag cct cag cct cag ccg caa ccc cag ccc caa tca caa ccc     1488
 Gln Pro Gln Pro Gln Pro Gln Pro Gln Pro Gln Pro Gln Ser Gln Pro
     320                 325                 330

 cag cct cag ccc caa ccc aag cct cag ccc cag cag ctc cac ccg tat     1536
 Gln Pro Gln Pro Gln Pro Lys Pro Gln Pro Gln Gln Leu His Pro Tyr
 335                 340                 345                 350

 ccg cat cca cat cca cat cca cac tct cat cct cac tcg cac cca cac     1584
 Pro His Pro His Pro His Pro His Ser His Pro His Ser His Pro His
                 355                 360                 365

 cct cac ccg cac ccg cat ccg cac caa ata ccg cac cca cac cca cag     1632
 Pro His Pro His Pro His Pro His Gln Ile Pro His Pro His Pro Gln
             370                 375                 380

 ccg cac tcg cag ccg cac ggg cac cgg ctt ctc cgc agc acc tcc aac     1680
 Pro His Ser Gln Pro His Gly His Arg Leu Leu Arg Ser Thr Ser Asn
         385                 390                 395

 tct gcc tgaaaggggc agctcccggg caagacaagg ttttgaggac ttgaggaagt      1736
 Ser Ala 
     400

 gggacgagca catttctatt gtcttcactt ggatcaaaag caaaacagtc tctccgcccc   1796

 gcaccagatc aagtagtttg gacatcaccc tactgaaaac ttgcgattct tcttagtttt   1856

 ctgcatactt ttcatcacga tgcaggaaac gatttcgagt caagaagact tttatttatg   1916

 aacctttgaa aggatcgtct tgtatggtga attttctagg agcgatgatg tactgtaatt   1976

 ttattttaat gtattttgat ttatgattat ttattagttt tttttaaatg cttgttctaa   2036

 gacatttctg aatgtagacc attttccaaa aaggaaactt tattttcaaa aacctaatcc   2096

 gtagtaattc ctaatcttgg agaataaaaa agggcggtgg aggggaaaac attaagaatt   2156

 tattcattat ttctcgagta ctttcagaaa gtctgacact ttcattgttg tgccagctgg   2216

 ttgaaattaa aactctgata ttaaaaaaaa aaaa                               2250




      <210> 103
      <211> 4050
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3816)

      <400> 103
  atg gcc cgc acc gtg gtg ctc atc acc ggc tgt tcc tcg ggc atc ggc      48
  Met Ala Arg Thr Val Val Leu Ile Thr Gly Cys Ser Ser Gly Ile Gly
    1               5                  10                  15

 ctg cac ttg gcc gta cgt ctg gct tca gat cca tcc cag agc ttc aaa       96
 Leu His Leu Ala Val Arg Leu Ala Ser Asp Pro Ser Gln Ser Phe Lys
              20                  25                  30

 gtg tat gcc acg ttg agg gac ctg aaa aca cag ggc cgg ctg tgg gag      144
 Val Tyr Ala Thr Leu Arg Asp Leu Lys Thr Gln Gly Arg Leu Trp Glu
          35                  40                  45

 gcg gcc cgg gcc ctg gca tgc cct ccg gga tcc ctg gag acg ttg cag      192
 Ala Ala Arg Ala Leu Ala Cys Pro Pro Gly Ser Leu Glu Thr Leu Gln
      50                  55                  60

 ctg gac gta agg gac tca aaa tcc gtg gcc gct gcc cgg gaa cgc gtg      240
 Leu Asp Val Arg Asp Ser Lys Ser Val Ala Ala Ala Arg Glu Arg Val
  65                  70                  75                  80

 act gag ggc cgc gtg gac gtg ctg gtg tgt aac gca ggc ctg ggc ctg      288
 Thr Glu Gly Arg Val Asp Val Leu Val Cys Asn Ala Gly Leu Gly Leu
                  85                  90                  95

 ctg ggg ccg ctg gag gcg ctg ggg gag gac gcc gtg gcc tct gtg ctg      336
 Leu Gly Pro Leu Glu Ala Leu Gly Glu Asp Ala Val Ala Ser Val Leu
             100                 105                 110

 gac gtg aat gta gta ggg act gtg cgg atg ctg cag gcc ttc ctg cca      384
 Asp Val Asn Val Val Gly Thr Val Arg Met Leu Gln Ala Phe Leu Pro
         115                 120                 125

 gac atg aag agg cgc ggt tcg gga cgc gtg ttg gtg acc ggg agc gtg      432
 Asp Met Lys Arg Arg Gly Ser Gly Arg Val Leu Val Thr Gly Ser Val
     130                 135                 140

 gga gga ttg atg ggg ctg cct ttc aat gac gtt tat tgc gcc agc aag      480
 Gly Gly Leu Met Gly Leu Pro Phe Asn Asp Val Tyr Cys Ala Ser Lys
 145                 150                 155                 160

 ttc gcg ctc gaa ggc tta tgc gag agt ctg gcg gtt ctg ctg ctg ccc      528
 Phe Ala Leu Glu Gly Leu Cys Glu Ser Leu Ala Val Leu Leu Leu Pro
                 165                 170                 175

 ttt ggg gtc cac agc ttg agc ctg atc gag tgc ggc cca gtg cac acc      576
 Phe Gly Val His Ser Leu Ser Leu Ile Glu Cys Gly Pro Val His Thr
             180                 185                 190

 gcc ttc atg gag aag gtg ttg ggc agc cca gag gag gtg ctg gac cgc      624
 Ala Phe Met Glu Lys Val Leu Gly Ser Pro Glu Glu Val Leu Asp Arg
         195                 200                 205

 acg gac atc cac acc ttc cac cgc ttc tac caa tac ctc gcc cac agc      672
 Thr Asp Ile His Thr Phe His Arg Phe Tyr Gln Tyr Leu Ala His Ser
     210                 215                 220

 aag caa gtc ttt cgc gag gcg gcg cag aac cct gag gag gtg gcg gag      720
 Lys Gln Val Phe Arg Glu Ala Ala Gln Asn Pro Glu Glu Val Ala Glu
 225                 230                 235                 240

 gtc ttc ctc acc gct ttg cgc gcc ccg aag ccg acc ctg cgc tac ttc      768
 Val Phe Leu Thr Ala Leu Arg Ala Pro Lys Pro Thr Leu Arg Tyr Phe
                 245                 250                 255

 acc acc gag cgc ttc ctg ccc ctg ctg cgg atg cgc ctg gac gac ccc      816
 Thr Thr Glu Arg Phe Leu Pro Leu Leu Arg Met Arg Leu Asp Asp Pro
             260                 265                 270

 agc ggc tcc aac tac gtc acc gcc atg cac cgg gaa gtg ttc ggc gac      864
 Ser Gly Ser Asn Tyr Val Thr Ala Met His Arg Glu Val Phe Gly Asp
         275                 280                 285

 gtt ccg gca aag gcc gag gct ggg gcc gag gct ggg ggc ggg gcc ggg      912
 Val Pro Ala Lys Ala Glu Ala Gly Ala Glu Ala Gly Gly Gly Ala Gly
     290                 295                 300

 cct ggg gca gag gac gag gcc ggg cgc agt gcg aga ccc cgc aaa caa      960
 Pro Gly Ala Glu Asp Glu Ala Gly Arg Ser Ala Arg Pro Arg Lys Gln
 305                 310                 315                 320

 gcg cat cag agg atc tgg gtg gtg cga gag cct cct aca gca gcc agg     1008
 Ala His Gln Arg Ile Trp Val Val Arg Glu Pro Pro Thr Ala Ala Arg
                 325                 330                 335

 tac aca caa ggc ctc agt ttt tcc atc tgt gaa atg ggt acg tgg aca     1056
 Tyr Thr Gln Gly Leu Ser Phe Ser Ile Cys Glu Met Gly Thr Trp Thr
             340                 345                 350

 gac ctg tcc agt agc ctc cca tgt gag aat cct cgg act gag agg cgg     1104
 Asp Leu Ser Ser Ser Leu Pro Cys Glu Asn Pro Arg Thr Glu Arg Arg
         355                 360                 365

 ggg tcc gat cgg cat caa gga ttc acc cac tcc cag agc ctt cgg gat     1152
 Gly Ser Asp Arg His Gln Gly Phe Thr His Ser Gln Ser Leu Arg Asp
     370                 375                 380

 cag ccc cac ccc atc agc agg aca cag ccc atg cca ctg gaa atc tcg     1200
 Gln Pro His Pro Ile Ser Arg Thr Gln Pro Met Pro Leu Glu Ile Ser
 385                 390                 395                 400

 cga gaa tcc cgc gct gaa gcg aag tcg aga cgt ttg acc ttc ctc cgt     1248
 Arg Glu Ser Arg Ala Glu Ala Lys Ser Arg Arg Leu Thr Phe Leu Arg
                 405                 410                 415

 ttc cgt agt tcc gag ttg cgg ttt ctc cgc ctg ggc agc atg gcc gta     1296
 Phe Arg Ser Ser Glu Leu Arg Phe Leu Arg Leu Gly Ser Met Ala Val
             420                 425                 430

 ttc cgg tcg ggt ctc ctg gtg ctg acg acg ccg ctg gcc tcc cta gcc     1344
 Phe Arg Ser Gly Leu Leu Val Leu Thr Thr Pro Leu Ala Ser Leu Ala
         435                 440                 445

 cct cgc ctg gcc tcc atc ctg acc tcg gcg gcc cgg ctg gtg aat cac     1392
 Pro Arg Leu Ala Ser Ile Leu Thr Ser Ala Ala Arg Leu Val Asn His
     450                 455                 460

 aca ctc tat gtt cac ctg cag ccg ggc atg agc ctg gag ggc ccg gct     1440
 Thr Leu Tyr Val His Leu Gln Pro Gly Met Ser Leu Glu Gly Pro Ala
 465                 470                 475                 480

 cag ccc cag tac agc ccc gtg cag gcc acg ttt gag gtt ctt gat ttc     1488
 Gln Pro Gln Tyr Ser Pro Val Gln Ala Thr Phe Glu Val Leu Asp Phe
                 485                 490                 495

 atc acg cac ctc tat gct ggc gcc gac gtc cac agg cac ttg gac gtc     1536
 Ile Thr His Leu Tyr Ala Gly Ala Asp Val His Arg His Leu Asp Val
             500                 505                 510

 aga atc cta ctg acc aat atc cga acc aag agc acc ttt ctc cct ccc     1584
 Arg Ile Leu Leu Thr Asn Ile Arg Thr Lys Ser Thr Phe Leu Pro Pro
         515                 520                 525

 ctg ccc acc tca gtc cag aat ctc gcc cac ccg cca gaa gtc gtg ttg     1632
 Leu Pro Thr Ser Val Gln Asn Leu Ala His Pro Pro Glu Val Val Leu
     530                 535                 540

 aca gat ttc cag acc ctg gat gga agc cag tac aac ccg gtc aaa cag     1680
 Thr Asp Phe Gln Thr Leu Asp Gly Ser Gln Tyr Asn Pro Val Lys Gln
 545                 550                 555                 560

 cag cta gtg cgt tac gcc acc agc tgt tac agc tgt tgt ccg cga ctg     1728
 Gln Leu Val Arg Tyr Ala Thr Ser Cys Tyr Ser Cys Cys Pro Arg Leu
                 565                 570                 575

 gcc tcg gtg ctg cta tac tcc gat tat ggg ata gga gaa gtg ccc gtg     1776
 Ala Ser Val Leu Leu Tyr Ser Asp Tyr Gly Ile Gly Glu Val Pro Val
             580                 585                 590

 gag ccc ctg gat gtc ccc tta ccc tcc acg atc agg cca gct tcc ccc     1824
 Glu Pro Leu Asp Val Pro Leu Pro Ser Thr Ile Arg Pro Ala Ser Pro
         595                 600                 605

 gtg gcc ggg tct cca aag cag ccg gtg cgt ggc tac tac cgt ggc gct     1872
 Val Ala Gly Ser Pro Lys Gln Pro Val Arg Gly Tyr Tyr Arg Gly Ala
     610                 615                 620

 gtc ggt ggc acg ttt gac cgc ctg cac aac gcc cac aag gtg ttg ctc     1920
 Val Gly Gly Thr Phe Asp Arg Leu His Asn Ala His Lys Val Leu Leu
 625                 630                 635                 640

 agt gtc gcg tgc atc ctg gcc cag gag cag ctt gtg gtg gga gta gca     1968
 Ser Val Ala Cys Ile Leu Ala Gln Glu Gln Leu Val Val Gly Val Ala
                 645                 650                 655

 gac aaa gat ctg ttg aag agc aag ttg ctc cct gag ctg ctc caa cct     2016
 Asp Lys Asp Leu Leu Lys Ser Lys Leu Leu Pro Glu Leu Leu Gln Pro
             660                 665                 670

 tat aca gaa cgt gtg gaa cat ctg agt gaa ttc ctg gtg gac atc aag     2064
 Tyr Thr Glu Arg Val Glu His Leu Ser Glu Phe Leu Val Asp Ile Lys
         675                 680                 685

 ccc tcc ttg act ttt gat gtc atc ccc ctg ctg gac ccc tat ggg ccc     2112
 Pro Ser Leu Thr Phe Asp Val Ile Pro Leu Leu Asp Pro Tyr Gly Pro
     690                 695                 700

 gct ggc tct gac ccc tcc ctg gag ttc ctg gtg gtc agc gag gag acc     2160
 Ala Gly Ser Asp Pro Ser Leu Glu Phe Leu Val Val Ser Glu Glu Thr
 705                 710                 715                 720

 tat cgt ggg ggg atg gcc atc aac cgc ttc cgc ctt gag aat gac ctg     2208
 Tyr Arg Gly Gly Met Ala Ile Asn Arg Phe Arg Leu Glu Asn Asp Leu
                 725                 730                 735

 gag gaa ctt gct ttg tac cag atc cag ctg ctg aag gac ctc aga cat     2256
 Glu Glu Leu Ala Leu Tyr Gln Ile Gln Leu Leu Lys Asp Leu Arg His
             740                 745                 750

 acg gag aat gaa gag gac aaa gtc agc tcc tcc agc ttc cgc cag cga     2304
 Thr Glu Asn Glu Glu Asp Lys Val Ser Ser Ser Ser Phe Arg Gln Arg
         755                 760                 765

 atg ttg ggg aac ctg ctt cgg cct cca tat gaa agg cca gag ctc ccc     2352
 Met Leu Gly Asn Leu Leu Arg Pro Pro Tyr Glu Arg Pro Glu Leu Pro
     770                 775                 780

 aca tgt ctc tat gta att ggg ctg act ggc atc agt ggc tct ggg aag     2400
 Thr Cys Leu Tyr Val Ile Gly Leu Thr Gly Ile Ser Gly Ser Gly Lys
 785                 790                 795                 800

 agc tca ata gct cag cga ctg aag ggc ctg ggg gcg ttt gtc att gac     2448
 Ser Ser Ile Ala Gln Arg Leu Lys Gly Leu Gly Ala Phe Val Ile Asp
                 805                 810                 815

 agt gac cac ctg ggt cat cgg gcc tat gcc cca ggt ggc cct gcc tac     2496
 Ser Asp His Leu Gly His Arg Ala Tyr Ala Pro Gly Gly Pro Ala Tyr
             820                 825                 830

 cag cct gtg gtg gag gcc ttt gga aca gat att ctc cat aaa gat ggc     2544
 Gln Pro Val Val Glu Ala Phe Gly Thr Asp Ile Leu His Lys Asp Gly
         835                 840                 845

 atc atc aac agg aag gtc cta ggc agc cgg gtg ttt ggg aat aag aag     2592
 Ile Ile Asn Arg Lys Val Leu Gly Ser Arg Val Phe Gly Asn Lys Lys
     850                 855                 860

 cag ctg aag ata ctc acg gac att atg tgg cca att atc gca aag ctg     2640
 Gln Leu Lys Ile Leu Thr Asp Ile Met Trp Pro Ile Ile Ala Lys Leu
 865                 870                 875                 880

 gcc cga gag gag atg gat cgg gct gtg gct gag gga aag cgt gtg tgt     2688
 Ala Arg Glu Glu Met Asp Arg Ala Val Ala Glu Gly Lys Arg Val Cys
                 885                 890                 895

 gtg att gat gcc gct gtg ttg ctt gaa gcc ggc tgg cag aac ctg gtc     2736
 Val Ile Asp Ala Ala Val Leu Leu Glu Ala Gly Trp Gln Asn Leu Val
             900                 905                 910

 cat gag gtg tgg act gct gtc atc cca gag act gag gct gta aga cgc     2784
 His Glu Val Trp Thr Ala Val Ile Pro Glu Thr Glu Ala Val Arg Arg
         915                 920                 925

 att gtg gag agg gat ggc ctc agt gaa gcc gcg gct caa agc cgg ctg     2832
 Ile Val Glu Arg Asp Gly Leu Ser Glu Ala Ala Ala Gln Ser Arg Leu
     930                 935                 940

 cag agc cag atg agc ggg cag cag ctt gtg gaa cag agc cac gtg gtg     2880
 Gln Ser Gln Met Ser Gly Gln Gln Leu Val Glu Gln Ser His Val Val
 945                 950                 955                 960

 ctc agc acc ttg tgg gag ccg cat atc acc caa cgc cag agc ttg cag     2928
 Leu Ser Thr Leu Trp Glu Pro His Ile Thr Gln Arg Gln Ser Leu Gln
                 965                 970                 975

 cct ggt ggg gtc gga cga tgt ggc tgg ggg ctt ctc tgc ccg gtt cct     2976
 Pro Gly Gly Val Gly Arg Cys Gly Trp Gly Leu Leu Cys Pro Val Pro
             980                 985                 990

 gac aca ccg gcc agc agt gca ggt ccg gtg gag tat gcc tac agc gac     3024
 Asp Thr Pro Ala Ser Ser Ala Gly Pro Val Glu Tyr Ala Tyr Ser Asp
         995                1000                1005

 aac agc ctg gac ccc ggg ctt ttt gta gaa agc acc cgc aag ggg agt     3072
 Asn Ser Leu Asp Pro Gly Leu Phe Val Glu Ser Thr Arg Lys Gly Ser
    1010                1015                1020

 gta gtg tcc aga gct aat agc atc ggt tcc acc agt gcc tct tct gtc     3120
 Val Val Ser Arg Ala Asn Ser Ile Gly Ser Thr Ser Ala Ser Ser Val
1025                1030                1035                1040

 ccc aac aca gat gat gag gac agt gat tac cac cag gag gcc tac aag     3168
 Pro Asn Thr Asp Asp Glu Asp Ser Asp Tyr His Gln Glu Ala Tyr Lys
                1045                1050                1055

 gag tcc tac aaa gac cgg cgg cgg cgc gca cac act cag gct gag cag     3216
 Glu Ser Tyr Lys Asp Arg Arg Arg Arg Ala His Thr Gln Ala Glu Gln
            1060                1065                1070

 aag agg agg gac gcc atc aag aga ggc tat gat gac ctt cag acc atc     3264
 Lys Arg Arg Asp Ala Ile Lys Arg Gly Tyr Asp Asp Leu Gln Thr Ile
        1075                1080                1085

 gtc ccc act tgc cag cag cag gac ttc tcc att ggc tcc caa aag ctc     3312
 Val Pro Thr Cys Gln Gln Gln Asp Phe Ser Ile Gly Ser Gln Lys Leu
    1090                1095                1100

 agc aaa gcc atc gtt cta caa aag agt atg gct agg gaa agc act gga     3360
 Ser Lys Ala Ile Val Leu Gln Lys Ser Met Ala Arg Glu Ser Thr Gly
1105                1110                1115                1120

 ggg gat gga gcc aag agg ggc tgt gaa gag gcc agt gcc tcc tac cca     3408
 Gly Asp Gly Ala Lys Arg Gly Cys Glu Glu Ala Ser Ala Ser Tyr Pro
                1125                1130                1135

 ccc atg gct cgg cct tgg tgt ggt gat tgc cat ggg ata gtt ggg gtc     3456
 Pro Met Ala Arg Pro Trp Cys Gly Asp Cys His Gly Ile Val Gly Val
            1140                1145                1150

 tgg gcc att gac tac att cag ttt ttg cac aag gag aag aaa aag cag     3504
 Trp Ala Ile Asp Tyr Ile Gln Phe Leu His Lys Glu Lys Lys Lys Gln
        1155                1160                1165

 gag gag gag gtg tcc acg tta cgc aag gat gtc acc gcc cta aag atc     3552
 Glu Glu Glu Val Ser Thr Leu Arg Lys Asp Val Thr Ala Leu Lys Ile
    1170                1175                1180

 atg aaa gtg aac tat gag cag att gtg aag gca cac cgg gac aac ccc     3600
 Met Lys Val Asn Tyr Glu Gln Ile Val Lys Ala His Arg Asp Asn Pro
1185                1190                1195                1200

 cat gaa ggg gag gac cag gtc tct gac cag gtc aag ttc aac gtg ttt     3648
 His Glu Gly Glu Asp Gln Val Ser Asp Gln Val Lys Phe Asn Val Phe
                1205                1210                1215

 caa ggc atc atg gat tcc ctg ttc cag tcc ttc aat gcc tcc atc tca     3696
 Gln Gly Ile Met Asp Ser Leu Phe Gln Ser Phe Asn Ala Ser Ile Ser
            1220                1225                1230

 gtg gcc agc ttc cag gag ctg tca gcg tgt gtc ttc agc tgg atc gag     3744
 Val Ala Ser Phe Gln Glu Leu Ser Ala Cys Val Phe Ser Trp Ile Glu
        1235                1240                1245

 gag cac tgt aag cct cag acc ctg cgg gag att gtg att ggc gtc ctg     3792
 Glu His Cys Lys Pro Gln Thr Leu Arg Glu Ile Val Ile Gly Val Leu
    1250                1255                1260

 cac caa ttg aaa aac cag ctt tac tgaccggttc ttggaaacct ggagaacagc    3846
 His Gln Leu Lys Asn Gln Leu Tyr 
1265                1270

 caacaagagg cccttgaatc tctacgtggc cactgaactg ctgggcccgg gagactggac   3906

 tacaacacct cacactggtc agctggtttc tacttggtgt ttggtttttc ccagccccat   3966

 tttatcttca gcggagccgc ggtgtttgtt ttgtgaaagc ttctgattaa tttattatat   4026

 tgacgataaa actcaaaaaa aaaa                                          4050




      <210> 104
      <211> 4041
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3075)

      <400> 104
  atg gcc cgc acc gtg gtg ctc atc acc ggc tgt tcc tcg ggc atc ggc      48
  Met Ala Arg Thr Val Val Leu Ile Thr Gly Cys Ser Ser Gly Ile Gly
    1               5                  10                  15

 ctg cac ttg gcc gta cgt ctg gct tca gat cca tcc cag agc ttc aaa       96
 Leu His Leu Ala Val Arg Leu Ala Ser Asp Pro Ser Gln Ser Phe Lys
              20                  25                  30

 gtg tat gcc acg ttg agg gac ctg aaa aca cag ggc cgg ctg tgg gag      144
 Val Tyr Ala Thr Leu Arg Asp Leu Lys Thr Gln Gly Arg Leu Trp Glu
          35                  40                  45

 gcg gcc cgg gcc ctg gca tgc cct ccg gga tcc ctg gag acg ttg cag      192
 Ala Ala Arg Ala Leu Ala Cys Pro Pro Gly Ser Leu Glu Thr Leu Gln
      50                  55                  60

 ctg gac gta agg gac tca aaa tcc gtg gcc gct gcc cgg gaa cgc gtg      240
 Leu Asp Val Arg Asp Ser Lys Ser Val Ala Ala Ala Arg Glu Arg Val
  65                  70                  75                  80

 act gag ggc cgc gtg gac gtg ctg gtg tgt aac gca ggc ctg ggc ctg      288
 Thr Glu Gly Arg Val Asp Val Leu Val Cys Asn Ala Gly Leu Gly Leu
                  85                  90                  95

 ctg ggg ccg ctg gag gcg ctg ggg gag gac gcc gtg gcc tct gtg ctg      336
 Leu Gly Pro Leu Glu Ala Leu Gly Glu Asp Ala Val Ala Ser Val Leu
             100                 105                 110

 gac gtg aat gta gta ggg act gtg cgg atg ctg cag gcc ttc ctg cca      384
 Asp Val Asn Val Val Gly Thr Val Arg Met Leu Gln Ala Phe Leu Pro
         115                 120                 125

 gac atg aag agg cgc ggt tcg gga cgc gtg ttg gtg acc ggg agc gtg      432
 Asp Met Lys Arg Arg Gly Ser Gly Arg Val Leu Val Thr Gly Ser Val
     130                 135                 140

 gga gga ttg atg ggg ctg cct ttc aat gac gtt tat tgc gcc agc aag      480
 Gly Gly Leu Met Gly Leu Pro Phe Asn Asp Val Tyr Cys Ala Ser Lys
 145                 150                 155                 160

 ttc gcg ctc gaa ggc tta tgc gag agt ctg gcg gtt ctg ctg ctg ccc      528
 Phe Ala Leu Glu Gly Leu Cys Glu Ser Leu Ala Val Leu Leu Leu Pro
                 165                 170                 175

 ttt ggg gtc cac agc ttg agc ctg atc gag tgc ggc cca gtg cac acc      576
 Phe Gly Val His Ser Leu Ser Leu Ile Glu Cys Gly Pro Val His Thr
             180                 185                 190

 gcc ttc atg gag aag gtg ttg ggc agc cca gag gag gtg ctg gac cgc      624
 Ala Phe Met Glu Lys Val Leu Gly Ser Pro Glu Glu Val Leu Asp Arg
         195                 200                 205

 acg gac atc cac acc ttc cac cgc ttc tac caa tac ctc gcc cac agc      672
 Thr Asp Ile His Thr Phe His Arg Phe Tyr Gln Tyr Leu Ala His Ser
     210                 215                 220

 aag caa gtc ttt cgc gag gcg gcg cag aac cct gag gag gtg gcg gag      720
 Lys Gln Val Phe Arg Glu Ala Ala Gln Asn Pro Glu Glu Val Ala Glu
 225                 230                 235                 240

 gtc ttc ctc acc gct ttg cgc gcc ccg aag ccg acc ctg cgc tac ttc      768
 Val Phe Leu Thr Ala Leu Arg Ala Pro Lys Pro Thr Leu Arg Tyr Phe
                 245                 250                 255

 acc acc gag cgc ttc ctg ccc ctg ctg cgg atg cgc ctg gac gac ccc      816
 Thr Thr Glu Arg Phe Leu Pro Leu Leu Arg Met Arg Leu Asp Asp Pro
             260                 265                 270

 agc ggc tcc aac tac gtc acc gcc atg cac cgg gaa gtg ttc ggc gac      864
 Ser Gly Ser Asn Tyr Val Thr Ala Met His Arg Glu Val Phe Gly Asp
         275                 280                 285

 gtt ccg gca aag gcc gag gct ggg gcc gag gct ggg ggc ggg gcc ggg      912
 Val Pro Ala Lys Ala Glu Ala Gly Ala Glu Ala Gly Gly Gly Ala Gly
     290                 295                 300

 cct ggg gca gag gac gag gcc ggg cgc agt gcg aga ccc cgc aaa caa      960
 Pro Gly Ala Glu Asp Glu Ala Gly Arg Ser Ala Arg Pro Arg Lys Gln
 305                 310                 315                 320

 gcg cat cag agg atc tgg gtg gtg cga gag cct cct aca gca gcc agg     1008
 Ala His Gln Arg Ile Trp Val Val Arg Glu Pro Pro Thr Ala Ala Arg
                 325                 330                 335

 tac aca caa ggc ctc agt ttt tcc atc tgt gaa atg ggt acg tgg aca     1056
 Tyr Thr Gln Gly Leu Ser Phe Ser Ile Cys Glu Met Gly Thr Trp Thr
             340                 345                 350

 gac ctg tcc agt agc ctc cca tgt gag aat cct cgg act gag agg cgg     1104
 Asp Leu Ser Ser Ser Leu Pro Cys Glu Asn Pro Arg Thr Glu Arg Arg
         355                 360                 365

 ggg tcc gat cgg cat caa gga ttc acc cac tcc cag agc ctt cgg gat     1152
 Gly Ser Asp Arg His Gln Gly Phe Thr His Ser Gln Ser Leu Arg Asp
     370                 375                 380

 cag ccc cac ccc atc agc agg aca cag ccc atg cca ctg gaa atc tcg     1200
 Gln Pro His Pro Ile Ser Arg Thr Gln Pro Met Pro Leu Glu Ile Ser
 385                 390                 395                 400

 cga gaa tcc cgc gct gaa gcg aag tcg aga cgt ttg acc ttc ctc cgt     1248
 Arg Glu Ser Arg Ala Glu Ala Lys Ser Arg Arg Leu Thr Phe Leu Arg
                 405                 410                 415

 ttc cgt agt tcc gag ttg cgg ttt ctc cgc ctg ggc agc atg gcc gta     1296
 Phe Arg Ser Ser Glu Leu Arg Phe Leu Arg Leu Gly Ser Met Ala Val
             420                 425                 430

 ttc cgg tcg ggt ctc ctg gtg ctg acg acg ccg ctg gcc tcc cta gcc     1344
 Phe Arg Ser Gly Leu Leu Val Leu Thr Thr Pro Leu Ala Ser Leu Ala
         435                 440                 445

 cct cgc ctg gcc tcc atc ctg acc tcg gcg gcc cgg ctg gtg aat cac     1392
 Pro Arg Leu Ala Ser Ile Leu Thr Ser Ala Ala Arg Leu Val Asn His
     450                 455                 460

 aca ctc tat gtt cac ctg cag ccg ggc atg agc ctg gag ggc ccg gct     1440
 Thr Leu Tyr Val His Leu Gln Pro Gly Met Ser Leu Glu Gly Pro Ala
 465                 470                 475                 480

 cag ccc cag tac agc ccc gtg cag gcc acg ttt gag gtt ctt gat ttc     1488
 Gln Pro Gln Tyr Ser Pro Val Gln Ala Thr Phe Glu Val Leu Asp Phe
                 485                 490                 495

 atc acg cac ctc tat gct ggc gcc gac gtc cac agg cac ttg gac gtc     1536
 Ile Thr His Leu Tyr Ala Gly Ala Asp Val His Arg His Leu Asp Val
             500                 505                 510

 aga atc cta ctg acc aat atc cga acc aag agc acc ttt ctc cct ccc     1584
 Arg Ile Leu Leu Thr Asn Ile Arg Thr Lys Ser Thr Phe Leu Pro Pro
         515                 520                 525

 ctg ccc acc tca gtc cag aat ctc gcc cac ccg cca gaa gtc gtg ttg     1632
 Leu Pro Thr Ser Val Gln Asn Leu Ala His Pro Pro Glu Val Val Leu
     530                 535                 540

 aca gat ttc cag acc ctg gat gga agc cag tac aac ccg gtc aaa cag     1680
 Thr Asp Phe Gln Thr Leu Asp Gly Ser Gln Tyr Asn Pro Val Lys Gln
 545                 550                 555                 560

 cag cta gtg cgt tac gcc acc agc tgt tac agc tgt tgt ccg cga ctg     1728
 Gln Leu Val Arg Tyr Ala Thr Ser Cys Tyr Ser Cys Cys Pro Arg Leu
                 565                 570                 575

 gcc tcg gtg ctg cta tac tcc gat tat ggg ata gga gaa gtg ccc gtg     1776
 Ala Ser Val Leu Leu Tyr Ser Asp Tyr Gly Ile Gly Glu Val Pro Val
             580                 585                 590

 gag ccc ctg gat gtc ccc tta ccc tcc acg atc agg cca gct tcc ccc     1824
 Glu Pro Leu Asp Val Pro Leu Pro Ser Thr Ile Arg Pro Ala Ser Pro
         595                 600                 605

 gtg gcc ggg tct cca aag cag ccg gtg cgt ggc tac tac cgt ggc gct     1872
 Val Ala Gly Ser Pro Lys Gln Pro Val Arg Gly Tyr Tyr Arg Gly Ala
     610                 615                 620

 gtc ggt ggc acg ttt gac cgc ctg cac aac gcc cac aag gtg ttg ctc     1920
 Val Gly Gly Thr Phe Asp Arg Leu His Asn Ala His Lys Val Leu Leu
 625                 630                 635                 640

 agt gtc gcg tgc atc ctg gcc cag gag cag ctt gtg gtg gga gta gca     1968
 Ser Val Ala Cys Ile Leu Ala Gln Glu Gln Leu Val Val Gly Val Ala
                 645                 650                 655

 gac aaa gat ctg ttg aag agc aag ttg ctc cct gag ctg ctc caa cct     2016
 Asp Lys Asp Leu Leu Lys Ser Lys Leu Leu Pro Glu Leu Leu Gln Pro
             660                 665                 670

 tat aca gaa cgt gtg gaa cat ctg agt gaa ttc ctg gtg gac atc aag     2064
 Tyr Thr Glu Arg Val Glu His Leu Ser Glu Phe Leu Val Asp Ile Lys
         675                 680                 685

 ccc tcc ttg act ttt gat gtc atc ccc ctg ctg gac ccc tat ggg ccc     2112
 Pro Ser Leu Thr Phe Asp Val Ile Pro Leu Leu Asp Pro Tyr Gly Pro
     690                 695                 700

 gct ggc tct gac ccc tcc ctg gag ttc ctg gtg gtc agc gag gag acc     2160
 Ala Gly Ser Asp Pro Ser Leu Glu Phe Leu Val Val Ser Glu Glu Thr
 705                 710                 715                 720

 tat cgt ggg ggg atg gcc atc aac cgc ttc cgc ctt gag aat gac ctg     2208
 Tyr Arg Gly Gly Met Ala Ile Asn Arg Phe Arg Leu Glu Asn Asp Leu
                 725                 730                 735

 gag gaa ctt gct ttg tac cag atc cag ctg ctg aag gac ctc aga cat     2256
 Glu Glu Leu Ala Leu Tyr Gln Ile Gln Leu Leu Lys Asp Leu Arg His
             740                 745                 750

 acg gag aat gaa gag gac aaa gtc agc tcc tcc agc ttc cgc cag cga     2304
 Thr Glu Asn Glu Glu Asp Lys Val Ser Ser Ser Ser Phe Arg Gln Arg
         755                 760                 765

 atg ttg ggg aac ctg ctt cgg cct cca tat gaa agg cca gag ctc ccc     2352
 Met Leu Gly Asn Leu Leu Arg Pro Pro Tyr Glu Arg Pro Glu Leu Pro
     770                 775                 780

 aca tgt ctc tat gta att ggg ctg act ggc atc agt ggc tct ggg aag     2400
 Thr Cys Leu Tyr Val Ile Gly Leu Thr Gly Ile Ser Gly Ser Gly Lys
 785                 790                 795                 800

 agc tca ata gct cag cga ctg aag ggc ctg ggg gcg ttt gtc att gac     2448
 Ser Ser Ile Ala Gln Arg Leu Lys Gly Leu Gly Ala Phe Val Ile Asp
                 805                 810                 815

 agt gac cac ctg ggt cat cgg gcc tat gcc cca ggt ggc cct gcc tac     2496
 Ser Asp His Leu Gly His Arg Ala Tyr Ala Pro Gly Gly Pro Ala Tyr
             820                 825                 830

 cag cct gtg gtg gag gcc ttt gga aca gat att ctc cat aaa gat ggc     2544
 Gln Pro Val Val Glu Ala Phe Gly Thr Asp Ile Leu His Lys Asp Gly
         835                 840                 845

 atc atc aac agg aag gtc cta ggc agc cgg gtg ttt ggg aat aag aag     2592
 Ile Ile Asn Arg Lys Val Leu Gly Ser Arg Val Phe Gly Asn Lys Lys
     850                 855                 860

 cag ctg aag ata ctc acg gac att atg tgg cca att atc gca aag ctg     2640
 Gln Leu Lys Ile Leu Thr Asp Ile Met Trp Pro Ile Ile Ala Lys Leu
 865                 870                 875                 880

 gcc cga gag gag atg gat cgg gct gtg gct gag gga aag cgt gtg tgt     2688
 Ala Arg Glu Glu Met Asp Arg Ala Val Ala Glu Gly Lys Arg Val Cys
                 885                 890                 895

 gtg att gat gcc gct gtg ttg ctt gaa gcc ggc tgg cag aac ctg gtc     2736
 Val Ile Asp Ala Ala Val Leu Leu Glu Ala Gly Trp Gln Asn Leu Val
             900                 905                 910

 cat gag gtg tgg act gct gtc atc cca gag act gag gct gta aga cgc     2784
 His Glu Val Trp Thr Ala Val Ile Pro Glu Thr Glu Ala Val Arg Arg
         915                 920                 925

 att gtg gag agg gat ggc ctc agt gaa gcc gcg gct caa agc cgg ctg     2832
 Ile Val Glu Arg Asp Gly Leu Ser Glu Ala Ala Ala Gln Ser Arg Leu
     930                 935                 940

 cag agc cag atg agc ggg cag cag ctt gtg gaa cag agc cac gtg gtg     2880
 Gln Ser Gln Met Ser Gly Gln Gln Leu Val Glu Gln Ser His Val Val
 945                 950                 955                 960

 ctc agc acc ttg tgg gag ccg cat atc acc caa cgc cag agc ttg cag     2928
 Leu Ser Thr Leu Trp Glu Pro His Ile Thr Gln Arg Gln Ser Leu Gln
                 965                 970                 975

 cct ggt ggg gtc gga cga tgt ggc tgg ggg ctt ctc tgc ccg gtt cct     2976
 Pro Gly Gly Val Gly Arg Cys Gly Trp Gly Leu Leu Cys Pro Val Pro
             980                 985                 990

 gac aca ccg gcc agc agt gca ggt ccg gtg gag tat gcc tac act gga     3024
 Asp Thr Pro Ala Ser Ser Ala Gly Pro Val Glu Tyr Ala Tyr Thr Gly
         995                1000                1005

 ccc cgg gct ttt tgt aga aag cac ccg caa ggg gag tgt agt gtc cag     3072
 Pro Arg Ala Phe Cys Arg Lys His Pro Gln Gly Glu Cys Ser Val Gln
    1010                1015                1020

 agc taat agcatcggtt ccaccagtgc ctcttctgtc cccaacacag atgatgagga     3129
 Ser 
1025

 cagtgattac caccaggagg cctacaagga gtcctacaaa gaccggcggc ggcgcgcaca   3189

 cactcaggct gagcagaaga ggagggacgc catcaagaga ggctatgatg accttcagac   3249

 catcgtcccc acttgccagc agcaggactt ctccattggc tcccaaaagc tcagcaaagc   3309

 catcgttcta caaaagagta tggctaggga aagcactgga ggggatggag ccaagagggg   3369

 ctgtgaagag gccagtgcct cctacccacc catggctcgg ccttggtgtg gtgattgcca   3429

 tgggatagtt ggggtctggg ccattgacta cattcagttt ttgcacaagg agaagaaaaa   3489

 gcaggaggag gaggtgtcca cgttacgcaa ggatgtcacc gccctaaaga tcatgaaagt   3549

 gaactatgag cagattgtga aggcacaccg ggacaacccc catgaagggg aggaccaggt   3609

 ctctgaccag gtcaagttca acgtgtttca aggcatcatg gattccctgt tccagtcctt   3669

 caatgcctcc atctcagtgg ccagcttcca ggagctgtca gcgtgtgtct tcagctggat   3729

 cgaggagcac tgtaagcctc agaccctgcg ggagattgtg attggcgtcc tgcaccaatt   3789

 gaaaaaccag ctttactgac cggttcttgg aaacctggag aacagccaac aagaggccct   3849

 tgaatctcta cgtggccact gaactgctgg gcccgggaga ctggactaca acacctcaca   3909

 ctggtcagct ggtttctact tggtgtttgg tttttcccag ccccatttta tcttcagcgg   3969

 agccgcggtg tttgttttgt gaaagcttct gattaattta ttatattgac gataaaactc   4029

 aaaaaaaaaa aa                                                       4041




      <210> 105
      <211> 4041
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3063)

      <400> 105
  atg gcc cgc acc gtg gtg ctc atc acc ggc tgt tcc tcg ggc atc ggc      48
  Met Ala Arg Thr Val Val Leu Ile Thr Gly Cys Ser Ser Gly Ile Gly
    1               5                  10                  15

 ctg cac ttg gcc gta cgt ctg gct tca gat cca tcc cag agc ttc aaa       96
 Leu His Leu Ala Val Arg Leu Ala Ser Asp Pro Ser Gln Ser Phe Lys
              20                  25                  30

 gtg tat gcc acg ttg agg gac ctg aaa aca cag ggc cgg ctg tgg gag      144
 Val Tyr Ala Thr Leu Arg Asp Leu Lys Thr Gln Gly Arg Leu Trp Glu
          35                  40                  45

 gcg gcc cgg gcc ctg gca tgc cct ccg gga tcc ctg gag acg ttg cag      192
 Ala Ala Arg Ala Leu Ala Cys Pro Pro Gly Ser Leu Glu Thr Leu Gln
      50                  55                  60

 ctg gac gta agg gac tca aaa tcc gtg gcc gct gcc cgg gaa cgc gtg      240
 Leu Asp Val Arg Asp Ser Lys Ser Val Ala Ala Ala Arg Glu Arg Val
  65                  70                  75                  80

 act gag ggc cgc gtg gac gtg ctg gtg tgt aac gca ggc ctg ggc ctg      288
 Thr Glu Gly Arg Val Asp Val Leu Val Cys Asn Ala Gly Leu Gly Leu
                  85                  90                  95

 ctg ggg ccg ctg gag gcg ctg ggg gag gac gcc gtg gcc tct gtg ctg      336
 Leu Gly Pro Leu Glu Ala Leu Gly Glu Asp Ala Val Ala Ser Val Leu
             100                 105                 110

 gac gtg aat gta gta ggg act gtg cgg atg ctg cag gcc ttc ctg cca      384
 Asp Val Asn Val Val Gly Thr Val Arg Met Leu Gln Ala Phe Leu Pro
         115                 120                 125

 gac atg aag agg cgc ggt tcg gga cgc gtg ttg gtg acc ggg agc gtg      432
 Asp Met Lys Arg Arg Gly Ser Gly Arg Val Leu Val Thr Gly Ser Val
     130                 135                 140

 gga gga ttg atg ggg ctg cct ttc aat gac gtt tat tgc gcc agc aag      480
 Gly Gly Leu Met Gly Leu Pro Phe Asn Asp Val Tyr Cys Ala Ser Lys
 145                 150                 155                 160

 ttc gcg ctc gaa ggc tta tgc gag agt ctg gcg gtt ctg ctg ctg ccc      528
 Phe Ala Leu Glu Gly Leu Cys Glu Ser Leu Ala Val Leu Leu Leu Pro
                 165                 170                 175

 ttt ggg gtc cac agc ttg agc ctg atc gag tgc ggc cca gtg cac acc      576
 Phe Gly Val His Ser Leu Ser Leu Ile Glu Cys Gly Pro Val His Thr
             180                 185                 190

 gcc ttc atg gag aag gtg ttg ggc agc cca gag gag gtg ctg gac cgc      624
 Ala Phe Met Glu Lys Val Leu Gly Ser Pro Glu Glu Val Leu Asp Arg
         195                 200                 205

 acg gac atc cac acc ttc cac cgc ttc tac caa tac ctc gcc cac agc      672
 Thr Asp Ile His Thr Phe His Arg Phe Tyr Gln Tyr Leu Ala His Ser
     210                 215                 220

 aag caa gtc ttt cgc gag gcg gcg cag aac cct gag gag gtg gcg gag      720
 Lys Gln Val Phe Arg Glu Ala Ala Gln Asn Pro Glu Glu Val Ala Glu
 225                 230                 235                 240

 gtc ttc ctc acc gct ttg cgc gcc ccg aag ccg acc ctg cgc tac ttc      768
 Val Phe Leu Thr Ala Leu Arg Ala Pro Lys Pro Thr Leu Arg Tyr Phe
                 245                 250                 255

 acc acc gag cgc ttc ctg ccc ctg ctg cgg atg cgc ctg gac gac ccc      816
 Thr Thr Glu Arg Phe Leu Pro Leu Leu Arg Met Arg Leu Asp Asp Pro
             260                 265                 270

 agc ggc tcc aac tac gtc acc gcc atg cac cgg gaa gtg ttc ggc gac      864
 Ser Gly Ser Asn Tyr Val Thr Ala Met His Arg Glu Val Phe Gly Asp
         275                 280                 285

 gtt ccg gca aag gcc gag gct ggg gcc gag gct ggg ggc ggg gcc ggg      912
 Val Pro Ala Lys Ala Glu Ala Gly Ala Glu Ala Gly Gly Gly Ala Gly
     290                 295                 300

 cct ggg gca gag gac gag gcc ggg cgc agt gcg aga ccc cgc aaa caa      960
 Pro Gly Ala Glu Asp Glu Ala Gly Arg Ser Ala Arg Pro Arg Lys Gln
 305                 310                 315                 320

 gcg cat cag agg atc tgg gtg gtg cga gag cct cct aca gca gcc agg     1008
 Ala His Gln Arg Ile Trp Val Val Arg Glu Pro Pro Thr Ala Ala Arg
                 325                 330                 335

 tac aca caa ggc ctc agt ttt tcc atc tgt gaa atg ggt acg tgg aca     1056
 Tyr Thr Gln Gly Leu Ser Phe Ser Ile Cys Glu Met Gly Thr Trp Thr
             340                 345                 350

 gac ctg tcc agt agc ctc cca tgt gag aat cct cgg act gag agg cgg     1104
 Asp Leu Ser Ser Ser Leu Pro Cys Glu Asn Pro Arg Thr Glu Arg Arg
         355                 360                 365

 ggg tcc gat cgg cat caa gga ttc acc cac tcc cag agc ctt cgg gat     1152
 Gly Ser Asp Arg His Gln Gly Phe Thr His Ser Gln Ser Leu Arg Asp
     370                 375                 380

 cag ccc cac ccc atc agc agg aca cag ccc atg cca ctg gaa atc tcg     1200
 Gln Pro His Pro Ile Ser Arg Thr Gln Pro Met Pro Leu Glu Ile Ser
 385                 390                 395                 400

 cga gaa tcc cgc gct gaa gcg aag tcg aga cgt ttg acc ttc ctc cgt     1248
 Arg Glu Ser Arg Ala Glu Ala Lys Ser Arg Arg Leu Thr Phe Leu Arg
                 405                 410                 415

 ttc cgt agt tcc gag ttg cgg ttt ctc cgc ctg ggc agc atg gcc gta     1296
 Phe Arg Ser Ser Glu Leu Arg Phe Leu Arg Leu Gly Ser Met Ala Val
             420                 425                 430

 ttc cgg tcg ggt ctc ctg gtg ctg acg acg ccg ctg gcc tcc cta gcc     1344
 Phe Arg Ser Gly Leu Leu Val Leu Thr Thr Pro Leu Ala Ser Leu Ala
         435                 440                 445

 cct cgc ctg gcc tcc atc ctg acc tcg gcg gcc cgg ctg gtg aat cac     1392
 Pro Arg Leu Ala Ser Ile Leu Thr Ser Ala Ala Arg Leu Val Asn His
     450                 455                 460

 aca ctc tat gtt cac ctg cag ccg ggc atg agc ctg gag ggc ccg gct     1440
 Thr Leu Tyr Val His Leu Gln Pro Gly Met Ser Leu Glu Gly Pro Ala
 465                 470                 475                 480

 cag ccc cag tac agc ccc gtg cag gcc acg ttt gag gtt ctt gat ttc     1488
 Gln Pro Gln Tyr Ser Pro Val Gln Ala Thr Phe Glu Val Leu Asp Phe
                 485                 490                 495

 atc acg cac ctc tat gct ggc gcc gac gtc cac agg cac ttg gac gtc     1536
 Ile Thr His Leu Tyr Ala Gly Ala Asp Val His Arg His Leu Asp Val
             500                 505                 510

 aga atc cta ctg acc aat atc cga acc aag agc acc ttt ctc cct ccc     1584
 Arg Ile Leu Leu Thr Asn Ile Arg Thr Lys Ser Thr Phe Leu Pro Pro
         515                 520                 525

 ctg ccc acc tca gtc cag aat ctc gcc cac ccg cca gaa gtc gtg ttg     1632
 Leu Pro Thr Ser Val Gln Asn Leu Ala His Pro Pro Glu Val Val Leu
     530                 535                 540

 aca gat ttc cag acc ctg gat gga agc cag tac aac ccg gtc aaa cag     1680
 Thr Asp Phe Gln Thr Leu Asp Gly Ser Gln Tyr Asn Pro Val Lys Gln
 545                 550                 555                 560

 cag cta gtg cgt tac gcc acc agc tgt tac agc tgt tgt ccg cga ctg     1728
 Gln Leu Val Arg Tyr Ala Thr Ser Cys Tyr Ser Cys Cys Pro Arg Leu
                 565                 570                 575

 gcc tcg gtg ctg cta tac tcc gat tat ggg ata gga gaa gtg ccc gtg     1776
 Ala Ser Val Leu Leu Tyr Ser Asp Tyr Gly Ile Gly Glu Val Pro Val
             580                 585                 590

 gag ccc ctg gat gtc ccc tta ccc tcc acg atc agg cca gct tcc ccc     1824
 Glu Pro Leu Asp Val Pro Leu Pro Ser Thr Ile Arg Pro Ala Ser Pro
         595                 600                 605

 gtg gcc ggg tct cca aag cag ccg gtg cgt ggc tac tac cgt ggc gct     1872
 Val Ala Gly Ser Pro Lys Gln Pro Val Arg Gly Tyr Tyr Arg Gly Ala
     610                 615                 620

 gtc ggt ggc acg ttt gac cgc ctg cac aac gcc cac aag gtg ttg ctc     1920
 Val Gly Gly Thr Phe Asp Arg Leu His Asn Ala His Lys Val Leu Leu
 625                 630                 635                 640

 agt gtc gcg tgc atc ctg gcc cag gag cag ctt gtg gtg gga gta gca     1968
 Ser Val Ala Cys Ile Leu Ala Gln Glu Gln Leu Val Val Gly Val Ala
                 645                 650                 655

 gac aaa gat ctg ttg aag agc aag ttg ctc cct gag ctg ctc caa cct     2016
 Asp Lys Asp Leu Leu Lys Ser Lys Leu Leu Pro Glu Leu Leu Gln Pro
             660                 665                 670

 tat aca gaa cgt gtg gaa cat ctg agt gaa ttc ctg gtg gac atc aag     2064
 Tyr Thr Glu Arg Val Glu His Leu Ser Glu Phe Leu Val Asp Ile Lys
         675                 680                 685

 ccc tcc ttg act ttt gat gtc atc ccc ctg ctg gac ccc tat ggg ccc     2112
 Pro Ser Leu Thr Phe Asp Val Ile Pro Leu Leu Asp Pro Tyr Gly Pro
     690                 695                 700

 gct ggc tct gac ccc tcc ctg gag ttc ctg gtg gtc agc gag gag acc     2160
 Ala Gly Ser Asp Pro Ser Leu Glu Phe Leu Val Val Ser Glu Glu Thr
 705                 710                 715                 720

 tat cgt ggg ggg atg gcc atc aac cgc ttc cgc ctt gag aat gac ctg     2208
 Tyr Arg Gly Gly Met Ala Ile Asn Arg Phe Arg Leu Glu Asn Asp Leu
                 725                 730                 735

 gag gaa ctt gct ttg tac cag atc cag ctg ctg aag gac ctc aga cat     2256
 Glu Glu Leu Ala Leu Tyr Gln Ile Gln Leu Leu Lys Asp Leu Arg His
             740                 745                 750

 acg gag aat gaa gag gac aaa gtc agc tcc tcc agc ttc cgc cag cga     2304
 Thr Glu Asn Glu Glu Asp Lys Val Ser Ser Ser Ser Phe Arg Gln Arg
         755                 760                 765

 atg ttg ggg aac ctg ctt cgg cct cca tat gaa agg cca gag ctc ccc     2352
 Met Leu Gly Asn Leu Leu Arg Pro Pro Tyr Glu Arg Pro Glu Leu Pro
     770                 775                 780

 aca tgt ctc tat gta att ggg ctg act ggc atc agt ggc tct ggg aag     2400
 Thr Cys Leu Tyr Val Ile Gly Leu Thr Gly Ile Ser Gly Ser Gly Lys
 785                 790                 795                 800

 agc tca ata gct cag cga ctg aag ggc ctg ggg gcg ttt gtc att gac     2448
 Ser Ser Ile Ala Gln Arg Leu Lys Gly Leu Gly Ala Phe Val Ile Asp
                 805                 810                 815

 agt gac cac ctg ggt cat cgg gcc tat gcc cca ggt ggc cct gcc tac     2496
 Ser Asp His Leu Gly His Arg Ala Tyr Ala Pro Gly Gly Pro Ala Tyr
             820                 825                 830

 cag cct gtg gtg gag gcc ttt gga aca gat att ctc cat aaa gat ggc     2544
 Gln Pro Val Val Glu Ala Phe Gly Thr Asp Ile Leu His Lys Asp Gly
         835                 840                 845

 atc atc aac agg aag gtc cta ggc agc cgg gtg ttt ggg aat aag aag     2592
 Ile Ile Asn Arg Lys Val Leu Gly Ser Arg Val Phe Gly Asn Lys Lys
     850                 855                 860

 cag ctg aag ata ctc acg gac att atg tgg cca att atc gca aag ctg     2640
 Gln Leu Lys Ile Leu Thr Asp Ile Met Trp Pro Ile Ile Ala Lys Leu
 865                 870                 875                 880

 gcc cga gag gag atg gat cgg gct gtg gct gag gga aag cgt gtg tgt     2688
 Ala Arg Glu Glu Met Asp Arg Ala Val Ala Glu Gly Lys Arg Val Cys
                 885                 890                 895

 gtg att gat gcc gct gtg ttg ctt gaa gcc ggc tgg cag aac ctg gtc     2736
 Val Ile Asp Ala Ala Val Leu Leu Glu Ala Gly Trp Gln Asn Leu Val
             900                 905                 910

 cat gag gtg tgg act gct gtc atc cca gag act gag gct gta aga cgc     2784
 His Glu Val Trp Thr Ala Val Ile Pro Glu Thr Glu Ala Val Arg Arg
         915                 920                 925

 att gtg gag agg gat ggc ctc agt gaa gcc gcg gct caa agc cgg ctg     2832
 Ile Val Glu Arg Asp Gly Leu Ser Glu Ala Ala Ala Gln Ser Arg Leu
     930                 935                 940

 cag agc cag atg agc ggg cag cag ctt gtg gaa cag agc cac gtg gtg     2880
 Gln Ser Gln Met Ser Gly Gln Gln Leu Val Glu Gln Ser His Val Val
 945                 950                 955                 960

 ctc agc acc ttg tgg gag ccg cat atc acc caa cgc cag agc ttg cag     2928
 Leu Ser Thr Leu Trp Glu Pro His Ile Thr Gln Arg Gln Ser Leu Gln
                 965                 970                 975

 cct ggt ggg gtc gga cga tgt ggc tgg ggg ctt ctc tgc ccg gtt cct     2976
 Pro Gly Gly Val Gly Arg Cys Gly Trp Gly Leu Leu Cys Pro Val Pro
             980                 985                 990

 gac aca ccg gcc agc agt gca ggt ccg gtg gag tat gcc tac agc gac     3024
 Asp Thr Pro Ala Ser Ser Ala Gly Pro Val Glu Tyr Ala Tyr Ser Asp
         995                1000                1005

 aac agc ctg gac ccc ggg ctt tta ccc gca agg gga gtg tagtgtccag      3073
 Asn Ser Leu Asp Pro Gly Leu Leu Pro Ala Arg Gly Val 
    1010                1015                1020

 agctaatagc atcggttcca ccagtgcctc ttctgtcccc aacacagatg atgaggacag   3133

 tgattaccac caggaggcct acaaggagtc ctacaaagac cggcggcggc gcgcacacac   3193

 tcaggctgag cagaagagga gggacgccat caagagaggc tatgatgacc ttcagaccat   3253

 cgtccccact tgccagcagc aggacttctc cattggctcc caaaagctca gcaaagccat   3313

 cgttctacaa aagagtatgg ctagggaaag cactggaggg gatggagcca agaggggctg   3373

 tgaagaggcc agtgcctcct acccacccat ggctcggcct tggtgtggtg attgccatgg   3433

 gatagttggg gtctgggcca ttgactacat tcagtttttg cacaaggaga agaaaaagca   3493

 ggaggaggag gtgtccacgt tacgcaagga tgtcaccgcc ctaaagatca tgaaagtgaa   3553

 ctatgagcag attgtgaagg cacaccggga caacccccat gaaggggagg accaggtctc   3613

 tgaccaggtc aagttcaacg tgtttcaagg catcatggat tccctgttcc agtccttcaa   3673

 tgcctccatc tcagtggcca gcttccagga gctgtcagcg tgtgtcttca gctggatcga   3733

 ggagcactgt aagcctcaga ccctgcggga gattgtgatt ggcgtcctgc accaattgaa   3793

 aaaccagctt tactgaccgg ttcttggaaa cctggagaac agccaacaag aggcccttga   3853

 atctctacgt ggccactgaa ctgctgggcc cgggagactg gactacaaca cctcacactg   3913

 gtcagctggt ttctacttgg tgtttggttt ttcccagccc cattttatct tcagcggagc   3973

 cgcggtgttt gttttgtgaa agcttctgat taatttatta tattgacgat aaaactcaaa   4033

 aaaaaaaa                                                            4041




      <210> 106
      <211> 4057
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3138)

      <400> 106
  atg gcc cgc acc gtg gtg ctc atc acc ggc tgt tcc tcg ggc atc ggc      48
  Met Ala Arg Thr Val Val Leu Ile Thr Gly Cys Ser Ser Gly Ile Gly
    1               5                  10                  15

 ctg cac ttg gcc gta cgt ctg gct tca gat cca tcc cag agc ttc aaa       96
 Leu His Leu Ala Val Arg Leu Ala Ser Asp Pro Ser Gln Ser Phe Lys
              20                  25                  30

 gtg tat gcc acg ttg agg gac ctg aaa aca cag ggc cgg ctg tgg gag      144
 Val Tyr Ala Thr Leu Arg Asp Leu Lys Thr Gln Gly Arg Leu Trp Glu
          35                  40                  45

 gcg gcc cgg gcc ctg gca tgc cct ccg gga tcc ctg gag acg ttg cag      192
 Ala Ala Arg Ala Leu Ala Cys Pro Pro Gly Ser Leu Glu Thr Leu Gln
      50                  55                  60

 ctg gac gta agg gac tca aaa tcc gtg gcc gct gcc cgg gaa cgc gtg      240
 Leu Asp Val Arg Asp Ser Lys Ser Val Ala Ala Ala Arg Glu Arg Val
  65                  70                  75                  80

 act gag ggc cgc gtg gac gtg ctg gtg tgt aac gca ggc ctg ggc ctg      288
 Thr Glu Gly Arg Val Asp Val Leu Val Cys Asn Ala Gly Leu Gly Leu
                  85                  90                  95

 ctg ggg ccg ctg gag gcg ctg ggg gag gac gcc gtg gcc tct gtg ctg      336
 Leu Gly Pro Leu Glu Ala Leu Gly Glu Asp Ala Val Ala Ser Val Leu
             100                 105                 110

 gac gtg aat gta gta ggg act gtg cgg atg ctg cag gcc ttc ctg cca      384
 Asp Val Asn Val Val Gly Thr Val Arg Met Leu Gln Ala Phe Leu Pro
         115                 120                 125

 gac atg aag agg cgc ggt tcg gga cgc gtg ttg gtg acc ggg agc gtg      432
 Asp Met Lys Arg Arg Gly Ser Gly Arg Val Leu Val Thr Gly Ser Val
     130                 135                 140

 gga gga ttg atg ggg ctg cct ttc aat gac gtt tat tgc gcc agc aag      480
 Gly Gly Leu Met Gly Leu Pro Phe Asn Asp Val Tyr Cys Ala Ser Lys
 145                 150                 155                 160

 ttc gcg ctc gaa ggc tta tgc gag agt ctg gcg gtt ctg ctg ctg ccc      528
 Phe Ala Leu Glu Gly Leu Cys Glu Ser Leu Ala Val Leu Leu Leu Pro
                 165                 170                 175

 ttt ggg gtc cac agc ttg agc ctg atc gag tgc ggc cca gtg cac acc      576
 Phe Gly Val His Ser Leu Ser Leu Ile Glu Cys Gly Pro Val His Thr
             180                 185                 190

 gcc ttc atg gag aag gtg ttg ggc agc cca gag gag gtg ctg gac cgc      624
 Ala Phe Met Glu Lys Val Leu Gly Ser Pro Glu Glu Val Leu Asp Arg
         195                 200                 205

 acg gac atc cac acc ttc cac cgc ttc tac caa tac ctc gcc cac agc      672
 Thr Asp Ile His Thr Phe His Arg Phe Tyr Gln Tyr Leu Ala His Ser
     210                 215                 220

 aag caa gtc ttt cgc gag gcg gcg cag aac cct gag gag gtg gcg gag      720
 Lys Gln Val Phe Arg Glu Ala Ala Gln Asn Pro Glu Glu Val Ala Glu
 225                 230                 235                 240

 gtc ttc ctc acc gct ttg cgc gcc ccg aag ccg acc ctg cgc tac ttc      768
 Val Phe Leu Thr Ala Leu Arg Ala Pro Lys Pro Thr Leu Arg Tyr Phe
                 245                 250                 255

 acc acc gag cgc ttc ctg ccc ctg ctg cgg atg cgc ctg gac gac ccc      816
 Thr Thr Glu Arg Phe Leu Pro Leu Leu Arg Met Arg Leu Asp Asp Pro
             260                 265                 270

 agc ggc tcc aac tac gtc acc gcc atg cac cgg gaa gtg ttc ggc gac      864
 Ser Gly Ser Asn Tyr Val Thr Ala Met His Arg Glu Val Phe Gly Asp
         275                 280                 285

 gtt ccg gca aag gcc gag gct ggg gcc gag gct ggg ggc ggg gcc ggg      912
 Val Pro Ala Lys Ala Glu Ala Gly Ala Glu Ala Gly Gly Gly Ala Gly
     290                 295                 300

 cct ggg gca gag gac gag gcc ggg cgc agt gcg aga ccc cgc aaa caa      960
 Pro Gly Ala Glu Asp Glu Ala Gly Arg Ser Ala Arg Pro Arg Lys Gln
 305                 310                 315                 320

 gcg cat cag agg atc tgg gtg gtg cga gag cct cct aca gca gcc agg     1008
 Ala His Gln Arg Ile Trp Val Val Arg Glu Pro Pro Thr Ala Ala Arg
                 325                 330                 335

 tac aca caa ggc ctc agt ttt tcc atc tgt gaa atg ggt acg tgg aca     1056
 Tyr Thr Gln Gly Leu Ser Phe Ser Ile Cys Glu Met Gly Thr Trp Thr
             340                 345                 350

 gac ctg tcc agt agc ctc cca tgt gag aat cct cgg act gag agg cgg     1104
 Asp Leu Ser Ser Ser Leu Pro Cys Glu Asn Pro Arg Thr Glu Arg Arg
         355                 360                 365

 ggg tcc gat cgg cat caa gga ttc acc cac tcc cag agc ctt cgg gat     1152
 Gly Ser Asp Arg His Gln Gly Phe Thr His Ser Gln Ser Leu Arg Asp
     370                 375                 380

 cag ccc cac ccc atc agc agg aca cag ccc atg cca ctg gaa atc tcg     1200
 Gln Pro His Pro Ile Ser Arg Thr Gln Pro Met Pro Leu Glu Ile Ser
 385                 390                 395                 400

 cga gaa tcc cgc gct gaa gcg aag tcg aga cgt ttg acc ttc ctc cgt     1248
 Arg Glu Ser Arg Ala Glu Ala Lys Ser Arg Arg Leu Thr Phe Leu Arg
                 405                 410                 415

 ttc cgt agt tcc gag ttg cgg ttt ctc cgc ctg ggc agc atg gcc gta     1296
 Phe Arg Ser Ser Glu Leu Arg Phe Leu Arg Leu Gly Ser Met Ala Val
             420                 425                 430

 ttc cgg tcg ggt ctc ctg gtg ctg acg acg ccg ctg gcc tcc cta gcc     1344
 Phe Arg Ser Gly Leu Leu Val Leu Thr Thr Pro Leu Ala Ser Leu Ala
         435                 440                 445

 cct cgc ctg gcc tcc atc ctg acc tcg gcg gcc cgg ctg gtg aat cac     1392
 Pro Arg Leu Ala Ser Ile Leu Thr Ser Ala Ala Arg Leu Val Asn His
     450                 455                 460

 aca ctc tat gtt cac ctg cag ccg ggc atg agc ctg gag ggc ccg gct     1440
 Thr Leu Tyr Val His Leu Gln Pro Gly Met Ser Leu Glu Gly Pro Ala
 465                 470                 475                 480

 cag ccc cag tac agc ccc gtg cag gcc acg ttt gag gtt ctt gat ttc     1488
 Gln Pro Gln Tyr Ser Pro Val Gln Ala Thr Phe Glu Val Leu Asp Phe
                 485                 490                 495

 atc acg cac ctc tat gct ggc gcc gac gtc cac agg cac ttg gac gtc     1536
 Ile Thr His Leu Tyr Ala Gly Ala Asp Val His Arg His Leu Asp Val
             500                 505                 510

 aga atc cta ctg acc aat atc cga acc aag agc acc ttt ctc cct ccc     1584
 Arg Ile Leu Leu Thr Asn Ile Arg Thr Lys Ser Thr Phe Leu Pro Pro
         515                 520                 525

 ctg ccc acc tca gtc cag aat ctc gcc cac ccg cca gaa gtc gtg ttg     1632
 Leu Pro Thr Ser Val Gln Asn Leu Ala His Pro Pro Glu Val Val Leu
     530                 535                 540

 aca gat ttc cag acc ctg gat gga agc cag tac aac ccg gtc aaa cag     1680
 Thr Asp Phe Gln Thr Leu Asp Gly Ser Gln Tyr Asn Pro Val Lys Gln
 545                 550                 555                 560

 cag cta gtg cgt tac gcc acc agc tgt tac agc tgt tgt ccg cga ctg     1728
 Gln Leu Val Arg Tyr Ala Thr Ser Cys Tyr Ser Cys Cys Pro Arg Leu
                 565                 570                 575

 gcc tcg gtg ctg cta tac tcc gat tat ggg ata gga gaa gtg ccc gtg     1776
 Ala Ser Val Leu Leu Tyr Ser Asp Tyr Gly Ile Gly Glu Val Pro Val
             580                 585                 590

 gag ccc ctg gat gtc ccc tta ccc tcc acg atc agg cca gct tcc ccc     1824
 Glu Pro Leu Asp Val Pro Leu Pro Ser Thr Ile Arg Pro Ala Ser Pro
         595                 600                 605

 gtg gcc ggg tct cca aag cag ccg gtg cgt ggc tac tac cgt ggc gct     1872
 Val Ala Gly Ser Pro Lys Gln Pro Val Arg Gly Tyr Tyr Arg Gly Ala
     610                 615                 620

 gtc ggt ggc acg ttt gac cgc ctg cac aac gcc cac aag gtg ttg ctc     1920
 Val Gly Gly Thr Phe Asp Arg Leu His Asn Ala His Lys Val Leu Leu
 625                 630                 635                 640

 agt gtc gcg tgc atc ctg gcc cag gag cag ctt gtg gtg gga gta gca     1968
 Ser Val Ala Cys Ile Leu Ala Gln Glu Gln Leu Val Val Gly Val Ala
                 645                 650                 655

 gac aaa gat ctg ttg aag agc aag ttg ctc cct gag ctg ctc caa cct     2016
 Asp Lys Asp Leu Leu Lys Ser Lys Leu Leu Pro Glu Leu Leu Gln Pro
             660                 665                 670

 tat aca gaa cgt gtg gaa cat ctg agt gaa ttc ctg gtg gac atc aag     2064
 Tyr Thr Glu Arg Val Glu His Leu Ser Glu Phe Leu Val Asp Ile Lys
         675                 680                 685

 ccc tcc ttg act ttt gat gtc atc ccc ctg ctg gac ccc tat ggg ccc     2112
 Pro Ser Leu Thr Phe Asp Val Ile Pro Leu Leu Asp Pro Tyr Gly Pro
     690                 695                 700

 gct ggc tct gac ccc tcc ctg gag ttc ctg gtg gtc agc gag gag acc     2160
 Ala Gly Ser Asp Pro Ser Leu Glu Phe Leu Val Val Ser Glu Glu Thr
 705                 710                 715                 720

 tat cgt ggg ggg atg gcc atc aac cgc ttc cgc ctt gag aat gac ctg     2208
 Tyr Arg Gly Gly Met Ala Ile Asn Arg Phe Arg Leu Glu Asn Asp Leu
                 725                 730                 735

 gag gaa ctt gct ttg tac cag atc cag ctg ctg aag gac ctc aga cat     2256
 Glu Glu Leu Ala Leu Tyr Gln Ile Gln Leu Leu Lys Asp Leu Arg His
             740                 745                 750

 acg gag aat gaa gag gac aaa gtc agc tcc tcc agc ttc cgc cag cga     2304
 Thr Glu Asn Glu Glu Asp Lys Val Ser Ser Ser Ser Phe Arg Gln Arg
         755                 760                 765

 atg ttg ggg aac ctg ctt cgg cct cca tat gaa agg cca gag ctc ccc     2352
 Met Leu Gly Asn Leu Leu Arg Pro Pro Tyr Glu Arg Pro Glu Leu Pro
     770                 775                 780

 aca tgt ctc tat gta att ggg ctg act ggc atc agt ggc tct ggg aag     2400
 Thr Cys Leu Tyr Val Ile Gly Leu Thr Gly Ile Ser Gly Ser Gly Lys
 785                 790                 795                 800

 agc tca ata gct cag cga ctg aag ggc ctg ggg gcg ttt gtc att gac     2448
 Ser Ser Ile Ala Gln Arg Leu Lys Gly Leu Gly Ala Phe Val Ile Asp
                 805                 810                 815

 agt gac cac ctg ggt cat cgg gcc tat gcc cca ggt ggc cct gcc tac     2496
 Ser Asp His Leu Gly His Arg Ala Tyr Ala Pro Gly Gly Pro Ala Tyr
             820                 825                 830

 cag cct gtg gtg gag gcc ttt gga aca gat att ctc cat aaa gat ggc     2544
 Gln Pro Val Val Glu Ala Phe Gly Thr Asp Ile Leu His Lys Asp Gly
         835                 840                 845

 atc atc aac agg aag gtc cta ggc agc cgg gtg ttt ggg aat aag aag     2592
 Ile Ile Asn Arg Lys Val Leu Gly Ser Arg Val Phe Gly Asn Lys Lys
     850                 855                 860

 cag ctg aag ata ctc acg gac att atg tgg cca att atc gca aag ctg     2640
 Gln Leu Lys Ile Leu Thr Asp Ile Met Trp Pro Ile Ile Ala Lys Leu
 865                 870                 875                 880

 gcc cga gag gag atg gat cgg gct gtg gct gag gga aag cgt gtg tgt     2688
 Ala Arg Glu Glu Met Asp Arg Ala Val Ala Glu Gly Lys Arg Val Cys
                 885                 890                 895

 gtg att gat gcc gct gtg ttg ctt gaa gcc ggc tgg cag aac ctg gtc     2736
 Val Ile Asp Ala Ala Val Leu Leu Glu Ala Gly Trp Gln Asn Leu Val
             900                 905                 910

 cat gag gtg tgg act gct gtc atc cca gag act gag gct gta aga cgc     2784
 His Glu Val Trp Thr Ala Val Ile Pro Glu Thr Glu Ala Val Arg Arg
         915                 920                 925

 att gtg gag agg gat ggc ctc agt gaa gcc gcg gct caa agc cgg ctg     2832
 Ile Val Glu Arg Asp Gly Leu Ser Glu Ala Ala Ala Gln Ser Arg Leu
     930                 935                 940

 cag agc cag atg agc ggg cag cag ctt gtg gaa cag agc cac gtg gtg     2880
 Gln Ser Gln Met Ser Gly Gln Gln Leu Val Glu Gln Ser His Val Val
 945                 950                 955                 960

 ctc agc acc ttg tgg gag ccg cat atc acc caa cgc cag agc ttg cag     2928
 Leu Ser Thr Leu Trp Glu Pro His Ile Thr Gln Arg Gln Ser Leu Gln
                 965                 970                 975

 cct ggt ggg gtc gga cga tgt ggc tgg ggg ctt ctc tgc ccg gtt cct     2976
 Pro Gly Gly Val Gly Arg Cys Gly Trp Gly Leu Leu Cys Pro Val Pro
             980                 985                 990

 gac aca ccg gcc agc agt gca ggt ccg gtg gag tat gcc tac agc gac     3024
 Asp Thr Pro Ala Ser Ser Ala Gly Pro Val Glu Tyr Ala Tyr Ser Asp
         995                1000                1005

 aac agc ctg gac ccc ggg ctt ttt gta gaa agc acc cgc aag ggg agt     3072
 Asn Ser Leu Asp Pro Gly Leu Phe Val Glu Ser Thr Arg Lys Gly Ser
    1010                1015                1020

 gta gtg tcc aga gct aat agc atc ggt tcc acc agt gcc tct tct gtc     3120
 Val Val Ser Arg Ala Asn Ser Ile Gly Ser Thr Ser Ala Ser Ser Val
1025                1030                1035                1040

 ccc aac act gag cgt aga tgatga ggacagtgat taccaccagg aggcctacaa     3174
 Pro Asn Thr Glu Arg Arg 
                1045

 ggagtcctac aaagaccggc ggcggcgcgc acacactcag gctgagcaga agaggaggga   3234

 cgccatcaag agaggctatg atgaccttca gaccatcgtc cccacttgcc agcagcagga   3294

 cttctccatt ggctcccaaa agctcagcaa agccatcgtt ctacaaaaga gtatggctag   3354

 ggaaagcact ggaggggatg gagccaagag gggctgtgaa gaggccagtg cctcctaccc   3414

 acccatggct cggccttggt gtggtgattg ccatgggata gttggggtct gggccattga   3474

 ctacattcag tttttgcaca aggagaagaa aaagcaggag gaggaggtgt ccacgttacg   3534

 caaggatgtc accgccctaa agatcatgaa agtgaactat gagcagattg tgaaggcaca   3594

 ccgggacaac ccccatgaag gggaggacca ggtctctgac caggtcaagt tcaacgtgtt   3654

 tcaaggcatc atggattccc tgttccagtc cttcaatgcc tccatctcag tggccagctt   3714

 ccaggagctg tcagcgtgtg tcttcagctg gatcgaggag cactgtaagc ctcagaccct   3774

 gcgggagatt gtgattggcg tcctgcacca attgaaaaac cagctttact gaccggttct   3834

 tggaaacctg gagaacagcc aacaagaggc ccttgaatct ctacgtggcc actgaactgc   3894

 tgggcccggg agactggact acaacacctc acactggtca gctggtttct acttggtgtt   3954

 tggtttttcc cagccccatt ttatcttcag cggagccgcg gtgtttgttt tgtgaaagct   4014

 tctgattaat ttattatatt gacgataaaa ctcaaaaaaa aaa                     4057




      <210> 107
      <211> 3214
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(879)

      <400> 107
  atg cgg ctg cac aga ctt cac gcg cgg ccg agc gcg gtg gcc tgt ggg      48
  Met Arg Leu His Arg Leu His Ala Arg Pro Ser Ala Val Ala Cys Gly
    1               5                  10                  15

 ctc ctg ctg ctt ctc ctc cag ggt cac tat gag gct ccc gcg gag ggc       96
 Leu Leu Leu Leu Leu Leu Gln Gly His Tyr Glu Ala Pro Ala Glu Gly
              20                  25                  30

 ctg tgc tgc cgg ccg gta ata aca gta ata gct tct ggc agc agc tgg      144
 Leu Cys Cys Arg Pro Val Ile Thr Val Ile Ala Ser Gly Ser Ser Trp
          35                  40                  45

 ctc tca atg tgt ggc gtc ctt ggc caa ggg ggc gcg ctg agc cct cca      192
 Leu Ser Met Cys Gly Val Leu Gly Gln Gly Gly Ala Leu Ser Pro Pro
      50                  55                  60

 aag ggg cct cag aca agc atg atg aga aag cct gcc tgt ttt gat ggt      240
 Lys Gly Pro Gln Thr Ser Met Met Arg Lys Pro Ala Cys Phe Asp Gly
  65                  70                  75                  80

 tcc aag ctt gga aag ttt ggg aaa gaa tcc aag aac atg gca ggt tat      288
 Ser Lys Leu Gly Lys Phe Gly Lys Glu Ser Lys Asn Met Ala Gly Tyr
                  85                  90                  95

 caa ggc gtt atc agc tgg gac aca aaa gga gag aag ggc ggg aag atg      336
 Gln Gly Val Ile Ser Trp Asp Thr Lys Gly Glu Lys Gly Gly Lys Met
             100                 105                 110

 ccg cgc gtc gtg ccc gac cag aga agc aag ttc gag aac gag gag ttt      384
 Pro Arg Val Val Pro Asp Gln Arg Ser Lys Phe Glu Asn Glu Glu Phe
         115                 120                 125

 ttt agg aag ctg agc cgc gag tgt gag att aag tac acg ggc ttc agg      432
 Phe Arg Lys Leu Ser Arg Glu Cys Glu Ile Lys Tyr Thr Gly Phe Arg
     130                 135                 140

 gac cgg ccc cac gag gaa cgc cag gca cgc ttc cag aac gcc tgc cgc      480
 Asp Arg Pro His Glu Glu Arg Gln Ala Arg Phe Gln Asn Ala Cys Arg
 145                 150                 155                 160

 gac ggc cgc tcg gaa atc gct ttt gtg gcc aca gga acc aat ctg tct      528
 Asp Gly Arg Ser Glu Ile Ala Phe Val Ala Thr Gly Thr Asn Leu Ser
                 165                 170                 175

 ctc cag ttt ttt ccg gcc agc tgg cag gga gaa cag cga caa aca cct      576
 Leu Gln Phe Phe Pro Ala Ser Trp Gln Gly Glu Gln Arg Gln Thr Pro
             180                 185                 190

 agc cga gag tat gtc gac tta gaa aga gaa gca ggc aag gta tat ttg      624
 Ser Arg Glu Tyr Val Asp Leu Glu Arg Glu Ala Gly Lys Val Tyr Leu
         195                 200                 205

 aag gct ccc atg att ctg aat gga gtc tgt gtt atc tgg aaa ggc tgg      672
 Lys Ala Pro Met Ile Leu Asn Gly Val Cys Val Ile Trp Lys Gly Trp
     210                 215                 220

 att gat ctc caa aga ctg gat ggt atg ggc tgt ctg gag ttt gat gag      720
 Ile Asp Leu Gln Arg Leu Asp Gly Met Gly Cys Leu Glu Phe Asp Glu
 225                 230                 235                 240

 gag cga gcc cag cag gag gat gca tta gca caa cag gcc ttt gaa gag      768
 Glu Arg Ala Gln Gln Glu Asp Ala Leu Ala Gln Gln Ala Phe Glu Glu
                 245                 250                 255

 gct cgg aga agg aca cgc gaa ttt gaa gat aga gac agg tct cat cgg      816
 Ala Arg Arg Arg Thr Arg Glu Phe Glu Asp Arg Asp Arg Ser His Arg
             260                 265                 270

 gag gaa atg gag gtg aga gtt tca cag ctg ctg gca gta act ggc aag      864
 Glu Glu Met Glu Val Arg Val Ser Gln Leu Leu Ala Val Thr Gly Lys
         275                 280                 285

 aag aca aca aga ccc tagtcctggt tccaatttag gtggtggtga tgacctcaaa      919
 Lys Thr Thr Arg Pro 
     290

 cttcgttaat taatagcaca gcagatgtgt gctgcccatc tttacataca cattgcttct    979

 agttggcaga aataattgat taaaagacca gaaactgtga taactggagg tactacggtc   1039

 tatttctcaa ccttaggcag taatagacat cacaaactgc catggttttg cactatgatt   1099

 ataatacctg catttctaat tttttaagca tgtagccagt aataatttga agtttttttt   1159

 ctatgcaagc ttaccttgtt ggcattattt tagggagttg aaactatcaa ctgtaaagct   1219

 ccttttcttc cactttaatt taaaagttca tgtcatttaa aaacaagtca agaaattaaa   1279

 attgtatcag agggttttct ctaatcattt tttctatttt tttttttgta cttctagatg   1339

 ttttggttat acagcttcat tttagatgag cattcttatt ttttgttttg tttgccccat   1399

 ttccttttgt gtttttatag tctatagcat tttaaaactg ctgatgttgt ttgcattatt   1459

 tacaggctaa aaacttagta gcatagagct gtctgccaca gccttctgac aaagtttaca   1519

 gttattaaag ttgcagtatc cttttaaatg ctagtaatca gcactctttt tttttttttt   1579

 ttttaataga gacagggtct cgcagtgttg cccaggctgg tctcgaactc ctggcatcaa   1639

 gcgatcctcc tgccttagcc tcccagagta ctgggattac aggctctttc tttttaaaca   1699

 taaaagtttt aaattggtat taactctgta ctctgcccta gattgtttta gcttctgttc   1759

 tgtaatcatg agtttggttg gagatattct ccatagatga tcttctactg aaatgcctaa   1819

 agaagtcaca ggctggcttc tgttttattc agggattttt ttaaaaagtc aatcagaaaa   1879

 gggatactgg agcttcttca tgtatgtaac agcatattaa actggagaca gtgatgaatc   1939

 agctacaaag gtaatattgt attaaaatca tgtttaagat agctgctttt atgtgtattt   1999

 tatattgcat gcttttgtaa aaacatgctg ggtgatgaaa gattagtttt agagagaaaa   2059

 tgttcatctg tgcagaggat gcattttctt ccattaattc tggaaaaaac gttcacagtt   2119

 atatatatgg tattttgcaa aaggactatt aatagaacct tttgagatga attaatgtaa   2179

 gaatattttt taaataggct tactgtcaaa ttgcaacttt ttttttagat acagagtgga   2239

 aaacagtgct aagtcatttg gcacctcctt acaaatattt ttcatggtca catttattaa   2299

 atgttactac atttctgaat ttttgaaaaa tgtattttat cattaaatgg cattatttta   2359

 aagggtgaaa aactgacaca gtcaattcag aaaatggact gaagtctgaa taaggtcatt   2419

 gcatttaaaa agcatataac tgtacttgac tgatgaggga ggtgttactt tcattgtata   2479

 taggtcttat ttcataaaca gatatcctgt atcaaataaa agtatttgtt atatatttga   2539

 agttatgcat ggaaaggagt gtgtttaaat tgttacaaac aataatgcgt cattaaaggc   2599

 catgctgatc ttgcataact ataagtacta tgaatgaatt tggttggttt tggtgttgta   2659

 cagctcacat gtttacacac tcagtgccct aatttcccct gagggaatcg ctttttaagt   2719

 gatccttaca gtggtgtttt atgttacttt attacagagc tccttggttt tttacttctg   2779

 cacttaaatt tttttaaata acatgatgat ggtacatttt cctctattgt ctagctaagg   2839

 gctttcggtc caccagtaaa taagatcaaa tgctcttaaa tgttcctgtt accatcctaa   2899

 tgtaaatact ggatttttct gtcatttagc accatgctgc ttctgtctgt cttaatgctg   2959

 gcattaagat catgagccct ttttctccag tagtacaggc tttgaaaact acttctatta   3019

 agttattgat gcaatttgat attttttcat aatctatatt taaacaaaat tacatcattg   3079

 catcatcttt tctaaattca tctccattaa aacttgcctt aagctaccag attgcttttg   3139

 ccaccattgg ccatactgtg tgtttgtttg tttaatttac tttcacaata aacttctgtg   3199

 tagtaaaaaa aaaaa                                                    3214




      <210> 108
      <211> 447
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (139)..(303)

      <400> 108
 ggcgccgagc tttacgctgg gctccctgct gcggacgttc aagcgggtca ggcctctact     60

 tttatctaca ccgctacccc tcaccgctga gggtcataac gcacgggtcc cccacggctc    120

 tgccacctgt agtgctcg  atg gtt cct tca tca gct tca ggc caa gtt cga     171
                      Met Val Pro Ser Ser Ala Ser Gly Gln Val Arg
                        1               5                  10

 agt cac tat gta gac tgg aga atg tgg cgc gat gtg aag aga cga aaa      219
 Ser His Tyr Val Asp Trp Arg Met Trp Arg Asp Val Lys Arg Arg Lys
              15                  20                  25

 atg gcc tat gaa tac gca gat gag agg cta cgt att aat tca ctc agg      267
 Met Ala Tyr Glu Tyr Ala Asp Glu Arg Leu Arg Ile Asn Ser Leu Arg
          30                  35                  40

 aag aat acc att ttg cca aaa att ctt cag gtt agc taat taagatgagt      317
 Lys Asn Thr Ile Leu Pro Lys Ile Leu Gln Val Ser 
      45                  50                  55

 ccctttgtac cacaagatca ttaactcaac atcagatcac ttttgatact gtttgttgtg    377

 acttggtatc aatataattt ctggagaata agatccacat caatataaac aaatagtctt    437

 tgaactgagg                                                           447




      <210> 109
      <211> 2005
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (224)..(1933)

      <400> 109
 gtgtctcgtg cctctgctgg accctgactc tgggctcctg gtcctggcag gaaaggggtt     60

 cagtcagcaa acggggctca gttcagactc atttcagggc gagaggcagc tgtactgtta    120

 cgaggtggtc ccgcagcagc cggcgctgag cccagtgacc cagtgtgtcc tggagagcgt    180

 gctgcgtggg gctgcccttg tgccccggca ggcgctggcc gtc  atg agc tgc gag     235
                                                  Met Ser Cys Glu
                                                    1

 gta ctc cgc gtc cta cag ctg agc gac aca gcc atc gtg ccc atc ggc      283
 Val Leu Arg Val Leu Gln Leu Ser Asp Thr Ala Ile Val Pro Ile Gly
   5                  10                  15                  20

 tac cat gtg ccc cgc aag gct gtg gag ttc cac gag gac ctg ttc ccg      331
 Tyr His Val Pro Arg Lys Ala Val Glu Phe His Glu Asp Leu Phe Pro
                  25                  30                  35

 gac act gcc ggc tgt gtg cct gcc acc gac ccc cat agc tgg tgg gct      379
 Asp Thr Ala Gly Cys Val Pro Ala Thr Asp Pro His Ser Trp Trp Ala
              40                  45                  50

 ggg gac aac cag cag gtg cag aag gtc agc ctc aac ccc gcc tgc cgg      427
 Gly Asp Asn Gln Gln Val Gln Lys Val Ser Leu Asn Pro Ala Cys Arg
          55                  60                  65

 ccc cac ccg agc ttc act tcc tgt ctg gtg ccc cct gcg gag ccc ctc      475
 Pro His Pro Ser Phe Thr Ser Cys Leu Val Pro Pro Ala Glu Pro Leu
      70                  75                  80

 cct gac aca gcc cag cct gcg gtg atg gag aca ccc gtg ggt gat gca      523
 Pro Asp Thr Ala Gln Pro Ala Val Met Glu Thr Pro Val Gly Asp Ala
  85                  90                  95                 100

 gac gca agc cct ggg gcc ctc act ctc cag cac cag tgg cat cgg gac      571
 Asp Ala Ser Pro Gly Ala Leu Thr Leu Gln His Gln Trp His Arg Asp
                 105                 110                 115

 cag ccc cag ttt gag gtc gct gca gag cct gct ggt tcc aag ttc cgc      619
 Gln Pro Gln Phe Glu Val Ala Ala Glu Pro Ala Gly Ser Lys Phe Arg
             120                 125                 130

 cat gct cag ggc act gtc ctg cac cga gac agc cac atc acc aac ctc      667
 His Ala Gln Gly Thr Val Leu His Arg Asp Ser His Ile Thr Asn Leu
         135                 140                 145

 aag ggg ctc aac ctc acc aca cct ggt gag agt gac ggc ttc tgt gcc      715
 Lys Gly Leu Asn Leu Thr Thr Pro Gly Glu Ser Asp Gly Phe Cys Ala
     150                 155                 160

 aac aag ctg cgt gtg gcc gtg ccg ctg ctc agc agc ggg gga cag gtg      763
 Asn Lys Leu Arg Val Ala Val Pro Leu Leu Ser Ser Gly Gly Gln Val
 165                 170                 175                 180

 gct gtg ctt gag cta cgg aag cct ggc cgc ctg ccc gac acg gca ctg      811
 Ala Val Leu Glu Leu Arg Lys Pro Gly Arg Leu Pro Asp Thr Ala Leu
                 185                 190                 195

 ccc acg ctg cag aat ggg gca gct gtg act gat ctg gcc tgg gac ccc      859
 Pro Thr Leu Gln Asn Gly Ala Ala Val Thr Asp Leu Ala Trp Asp Pro
             200                 205                 210

 ttt gac ccc cat cgc ctc gct gtg gct ggt gag gac gcc agg atc cga      907
 Phe Asp Pro His Arg Leu Ala Val Ala Gly Glu Asp Ala Arg Ile Arg
         215                 220                 225

 ctg tgg cgg gta ccc gca gag ggc ctg gaa gag gtg ctc acc acg cca      955
 Leu Trp Arg Val Pro Ala Glu Gly Leu Glu Glu Val Leu Thr Thr Pro
     230                 235                 240

 gag act gtg ctc aca ggc cac acg gag aag atc tgc tcc ctg cgc ttc     1003
 Glu Thr Val Leu Thr Gly His Thr Glu Lys Ile Cys Ser Leu Arg Phe
 245                 250                 255                 260

 cac cca ctg gca gcc aat gtg ctg gcc tcg tcc tcc tat gac ctc act     1051
 His Pro Leu Ala Ala Asn Val Leu Ala Ser Ser Ser Tyr Asp Leu Thr
                 265                 270                 275

 gtt cgc atc tgg gac ctt cag gct gga gct gat cgg ctg aag ctg cag     1099
 Val Arg Ile Trp Asp Leu Gln Ala Gly Ala Asp Arg Leu Lys Leu Gln
             280                 285                 290

 ggc cac caa gac cag atc ttc agc ctg gcc tgg agt cct gat ggg cag     1147
 Gly His Gln Asp Gln Ile Phe Ser Leu Ala Trp Ser Pro Asp Gly Gln
         295                 300                 305

 cag ctg gcc act gtc tgc aag gat ggg cgt gtg cgg gtc tac agg ccc     1195
 Gln Leu Ala Thr Val Cys Lys Asp Gly Arg Val Arg Val Tyr Arg Pro
     310                 315                 320

 cgg agt ggc cct gag ccc ctg cag gaa ggc cca ggg ccc aag gga gga     1243
 Arg Ser Gly Pro Glu Pro Leu Gln Glu Gly Pro Gly Pro Lys Gly Gly
 325                 330                 335                 340

 cgc gga gct cgc att gtc tgg gta tgt gat ggt cgc tgt ctg ctg gtg     1291
 Arg Gly Ala Arg Ile Val Trp Val Cys Asp Gly Arg Cys Leu Leu Val
                 345                 350                 355

 tct ggc ttt gac agc caa agt gag cgc cag ctg ctc cta tat gaa gct     1339
 Ser Gly Phe Asp Ser Gln Ser Glu Arg Gln Leu Leu Leu Tyr Glu Ala
             360                 365                 370

 gag gcc ctg gcc ggc gga ccc ttg gca gtg ttg ggc ctg gac gtg gct     1387
 Glu Ala Leu Ala Gly Gly Pro Leu Ala Val Leu Gly Leu Asp Val Ala
         375                 380                 385

 ccc tca acc ctg ctg ccc agc tac gac cca gac act ggc ctg gtg ctc     1435
 Pro Ser Thr Leu Leu Pro Ser Tyr Asp Pro Asp Thr Gly Leu Val Leu
     390                 395                 400

 ctg acc ggc aag ggc gac acc cgt gta ttc ctg tac gag ctg ctc ccc     1483
 Leu Thr Gly Lys Gly Asp Thr Arg Val Phe Leu Tyr Glu Leu Leu Pro
 405                 410                 415                 420

 gag tcc cct ttc ttc ctg gag tgc aac agc ttc acg tcg cct gac ccc     1531
 Glu Ser Pro Phe Phe Leu Glu Cys Asn Ser Phe Thr Ser Pro Asp Pro
                 425                 430                 435

 cac aag ggc ctc gtc ctc ctg cct aag acg gag tgc gac gtg cgg gaa     1579
 His Lys Gly Leu Val Leu Leu Pro Lys Thr Glu Cys Asp Val Arg Glu
             440                 445                 450

 gtg gag ctg atg cgg tgc ctg cgg ctg cgt cag tcc tcc ctg gag cct     1627
 Val Glu Leu Met Arg Cys Leu Arg Leu Arg Gln Ser Ser Leu Glu Pro
         455                 460                 465

 gtg gcc ttc cgg ctg ccc cga gtc cgg aaa gag ttc ttc cag gat gac     1675
 Val Ala Phe Arg Leu Pro Arg Val Arg Lys Glu Phe Phe Gln Asp Asp
     470                 475                 480

 gtg ttc cca gac acg gct gtg atc tgg gag cct gtg ctc agt gcc gag     1723
 Val Phe Pro Asp Thr Ala Val Ile Trp Glu Pro Val Leu Ser Ala Glu
 485                 490                 495                 500

 gcc tgg ctg caa ggc gct aat ggg cag ccc tgg ctt ctc agc ctg cag     1771
 Ala Trp Leu Gln Gly Ala Asn Gly Gln Pro Trp Leu Leu Ser Leu Gln
                 505                 510                 515

 cct cct gac atg agc cca ggt gca ccg agg gac tgg gtg tgg gga gga     1819
 Pro Pro Asp Met Ser Pro Gly Ala Pro Arg Asp Trp Val Trp Gly Gly
             520                 525                 530

 agc ggg atg ggg gtt gga gaa agg gac aga agg ccc agg ttg aag ttc     1867
 Ser Gly Met Gly Val Gly Glu Arg Asp Arg Arg Pro Arg Leu Lys Phe
         535                 540                 545

 cat tcc tgt tgg cac gca gaa tcc tct ggc ctt tgg gag ggt gga gtg     1915
 His Ser Cys Trp His Ala Glu Ser Ser Gly Leu Trp Glu Gly Gly Val
     550                 555                 560

 gct gtg tca atc agt ctc tgagcc agtggagggc agggctcgtg gtctgtgttt     1969
 Ala Val Ser Ile Ser Leu 
 565                 570

 tcatcacagg tccccacccc ccccaaaaaa aaaaaa                             2005




      <210> 110
      <211> 740
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (191)..(466)

      <400> 110
 cggccgcgtc gacggagagt gtcatggagg cctacgagca ggtccaaaag ggacccctga     60

 agctgaaagg cgtcgcaaag ctgggagtga ccaagcggtg aggcccgagg gcccgcggga    120

 ttccgtcttc atccccctta gaccttttct cgggacccct ggccctgatc ctccgacccg    180

 ccgcctcctc   atg tct ttt tcc agg aag aag aaa aag aag gac aaa gac     229
              Met Ser Phe Ser Arg Lys Lys Lys Lys Lys Asp Lys Asp
                1               5                  10

 aaa gcg aaa ctc ctg gaa gca atg gga acg agc aaa aag aac gag gag      277
 Lys Ala Lys Leu Leu Glu Ala Met Gly Thr Ser Lys Lys Asn Glu Glu
      15                  20                  25

 gag aag cgg cgc ggc ctg gac aag cgg acc ccg gcc cag gcg gcc ttc      325
 Glu Lys Arg Arg Gly Leu Asp Lys Arg Thr Pro Ala Gln Ala Ala Phe
  30                  35                  40                  45

 gag aaa atg cag gag aag cgg caa atg gaa agg atc cta aag aag gca      373
 Glu Lys Met Gln Glu Lys Arg Gln Met Glu Arg Ile Leu Lys Lys Ala
                  50                  55                  60

 tcc aaa acc cac aag cag aga gtg gag gac ttc aac aga cac ctg gac      421
 Ser Lys Thr His Lys Gln Arg Val Glu Asp Phe Asn Arg His Leu Asp
              65                  70                  75

 aca ctc acg gag cat tac gac att ccc aaa gtc agc tgg acg aag tag      469
 Thr Leu Thr Glu His Tyr Asp Ile Pro Lys Val Ser Trp Thr Lys 
          80                  85                  90

 ccgcctgccc ccagtatgga gcagcatcga gggttcgcaa aaggccacac tggggttgtg    529

 tgtgtttcct ttggtatatt ctggaaacat ggctacacac acccttgcat cttctgctac    589

 agactgcttt tcgaagctgt gtaccctcat tctggaactt gattaaagta agatcgtcct    649

 tgtactcagt ttaggcttct tggcaacata cagaagatac acccttttcg tttggatgga    709

 aagtttctaa gtttatccag aggtaaagcc t                                   740




      <210> 111
      <211> 792
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (18)..(749)

      <220>
      <221> misc_feature
      <222> (1)...(792)
      <223> n = a,t,c or g

      <400> 111
 ctcagagctg gtctgcc   atg gac atc ctg gtc cca ctc ctg cag ctg ctg      50
                      Met Asp Ile Leu Val Pro Leu Leu Gln Leu Leu
                        1               5                  10

 gtg ctg ctt ctt acc ctg ccc ctg cac ctc atg gct ctg ctg ggc tgc       98
 Val Leu Leu Leu Thr Leu Pro Leu His Leu Met Ala Leu Leu Gly Cys
              15                  20                  25

 tgg cag ccc ctg tgc aaa agc tac ttc ccc tac ctg atg gcc gtg ctg      146
 Trp Gln Pro Leu Cys Lys Ser Tyr Phe Pro Tyr Leu Met Ala Val Leu
          30                  35                  40

 act ccc aag agc aac cgc aag atg gag agc aag aaa cgg gag ctc ttc      194
 Thr Pro Lys Ser Asn Arg Lys Met Glu Ser Lys Lys Arg Glu Leu Phe
      45                  50                  55

 agc cag ata aag ggg ctt aca gga gcc tcc ggg aaa gtg gcc cta ctg      242
 Ser Gln Ile Lys Gly Leu Thr Gly Ala Ser Gly Lys Val Ala Leu Leu
  60                  65                  70                  75

 gag ctg ggc tgc gga acc gga gcc aac ttt cag ttc tac cca ccg ggc      290
 Glu Leu Gly Cys Gly Thr Gly Ala Asn Phe Gln Phe Tyr Pro Pro Gly
                  80                  85                  90

 tgc agg gtc acc tgc cta gac cca aat ccc cac ttt gag aag ttc ctg      338
 Cys Arg Val Thr Cys Leu Asp Pro Asn Pro His Phe Glu Lys Phe Leu
              95                 100                 105

 aca aag agc atg gct gag aac agg cac ctc caa tat gag cgg ttt gtg      386
 Thr Lys Ser Met Ala Glu Asn Arg His Leu Gln Tyr Glu Arg Phe Val
         110                 115                 120

 gtg gct cct gga gag gac atg aga cag ctg gct gat ggc tcc atg gat      434
 Val Ala Pro Gly Glu Asp Met Arg Gln Leu Ala Asp Gly Ser Met Asp
     125                 130                 135

 gtg gtg gtc tgc act ctg gtg ctg tgc tct gtg cag agc cca agg aag      482
 Val Val Val Cys Thr Leu Val Leu Cys Ser Val Gln Ser Pro Arg Lys
 140                 145                 150                 155

 gtc ctg cag gag gtc cgg aga gta ctg aga ccg gga ggt gtg ctc ttt      530
 Val Leu Gln Glu Val Arg Arg Val Leu Arg Pro Gly Gly Val Leu Phe
                 160                 165                 170

 ttc tgg gag cat gtg gca gaa cca tat gga agc tgg gcc ttc atg tgg      578
 Phe Trp Glu His Val Ala Glu Pro Tyr Gly Ser Trp Ala Phe Met Trp
             175                 180                 185

 cag caa gtt ttc gag ccc acc tgg aaa cac att ggg gat ggc tgc tgc      626
 Gln Gln Val Phe Glu Pro Thr Trp Lys His Ile Gly Asp Gly Cys Cys
         190                 195                 200

 ctc acc aga gag acc tgg aag gat ctt gag aac gcc cag ttc tcc gaa      674
 Leu Thr Arg Glu Thr Trp Lys Asp Leu Glu Asn Ala Gln Phe Ser Glu
     205                 210                 215

 atc caa atg gaa cga cag ccc cct ccc ttg aag tgg cta cct gat ggg      722
 Ile Gln Met Glu Arg Gln Pro Pro Pro Leu Lys Trp Leu Pro Asp Gly
 220                 225                 230                 235

 cac cac atc atg gga aag gct gtc aaa taatc gacagcgaag tcgacgnnnn      774
 His His Ile Met Gly Lys Ala Val Lys 
                 240

 aattccggag cggtcgcg                                                  792




      <210> 112
      <211> 2295
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2292)

      <400> 112
  atg aca tgt ctc cgc acc ggc acc gag ggg gcg cag ggc ggc gtg ggg      48
  Met Thr Cys Leu Arg Thr Gly Thr Glu Gly Ala Gln Gly Gly Val Gly
    1               5                  10                  15

 agg ggg acc cag gcc ggg ggt ccg ggt ggc gcg ccc tct ctc acc ccc       96
 Arg Gly Thr Gln Ala Gly Gly Pro Gly Gly Ala Pro Ser Leu Thr Pro
              20                  25                  30

 gag gcg gca gga gca gcg cgg cgc gag gac acc tcc ggg ccg tcg gtg      144
 Glu Ala Ala Gly Ala Ala Arg Arg Glu Asp Thr Ser Gly Pro Ser Val
          35                  40                  45

 ccc ctg agc ttc ccg gcg gcg cgc tgc ccc agg aaa gtt ccc ggc ctg      192
 Pro Leu Ser Phe Pro Ala Ala Arg Cys Pro Arg Lys Val Pro Gly Leu
      50                  55                  60

 ccg ccc ctc ggg ctg ttg gaa agt ttc ggc ggc tgc agg gcc ctg gca      240
 Pro Pro Leu Gly Leu Leu Glu Ser Phe Gly Gly Cys Arg Ala Leu Ala
  65                  70                  75                  80

 gct agg cgc caa gcg tcg cgc ggg gcg ggc acg gct gcg ggg tcg ggc      288
 Ala Arg Arg Gln Ala Ser Arg Gly Ala Gly Thr Ala Ala Gly Ser Gly
                  85                  90                  95

 cgc gct cgg ctg gag tgc tca gtg caa gac gcc cgg acg ggc cca gcg      336
 Arg Ala Arg Leu Glu Cys Ser Val Gln Asp Ala Arg Thr Gly Pro Ala
             100                 105                 110

 cgc aac ccg aga ccc cgg gcc agc cct ccc gcc ctc acg cgg ccc gtg      384
 Arg Asn Pro Arg Pro Arg Ala Ser Pro Pro Ala Leu Thr Arg Pro Val
         115                 120                 125

 cgc aaa gcg gac cgg gcc ggc gac gcg aat ctc cgc ccc gcc cca tct      432
 Arg Lys Ala Asp Arg Ala Gly Asp Ala Asn Leu Arg Pro Ala Pro Ser
     130                 135                 140

 gac agc aaa ttt tcc cat tgg tcg aga gac ccg gcg cgg cac ggc aac      480
 Asp Ser Lys Phe Ser His Trp Ser Arg Asp Pro Ala Arg His Gly Asn
 145                 150                 155                 160

 cgg cgc cga ttg ggc gga tgc gcg gag atg acg gct tgc cat tgg gcc      528
 Arg Arg Arg Leu Gly Gly Cys Ala Glu Met Thr Ala Cys His Trp Ala
                 165                 170                 175

 tcc ggg atg tca gtc ccg gcg gat gac cgg ccc cct cgc gga ggg gcc      576
 Ser Gly Met Ser Val Pro Ala Asp Asp Arg Pro Pro Arg Gly Gly Ala
             180                 185                 190

 gcg gcc ccg cac ctg ccc gaa cct ctg cgg cgg cgg tgg cag ggt acg      624
 Ala Ala Pro His Leu Pro Glu Pro Leu Arg Arg Arg Trp Gln Gly Thr
         195                 200                 205

 cgg gac cgc tcc ctc cca gcc gac tta cga gaa cat ccc ccg acc atc      672
 Arg Asp Arg Ser Leu Pro Ala Asp Leu Arg Glu His Pro Pro Thr Ile
     210                 215                 220

 cag ccc cga gca ggg act ggc aga gcc ggc gcc cct tcc ccg gac tct      720
 Gln Pro Arg Ala Gly Thr Gly Arg Ala Gly Ala Pro Ser Pro Asp Ser
 225                 230                 235                 240

 ggc cgc gta gcc tcc gcc acc act ccc agt tca cag gta tcc ttc ttc      768
 Gly Arg Val Ala Ser Ala Thr Thr Pro Ser Ser Gln Val Ser Phe Phe
                 245                 250                 255

 agc gcc tgc tac tcg ctg cgc gct gcg cgc cgc tcc ctc ctg tcg aca      816
 Ser Ala Cys Tyr Ser Leu Arg Ala Ala Arg Arg Ser Leu Leu Ser Thr
             260                 265                 270

 tcg aat tgt att ctt cac gca agc cgc gag aga gag ttc tgc tgc tat      864
 Ser Asn Cys Ile Leu His Ala Ser Arg Glu Arg Glu Phe Cys Cys Tyr
         275                 280                 285

 ccc cat ttt aca gtt ggg aaa cag cct cag aga ggt tct cac ttg ctt      912
 Pro His Phe Thr Val Gly Lys Gln Pro Gln Arg Gly Ser His Leu Leu
     290                 295                 300

 gaa cac agt cgt ctg acc ctg ggg cct ggg ggc tct ctc atc ctc acg      960
 Glu His Ser Arg Leu Thr Leu Gly Pro Gly Gly Ser Leu Ile Leu Thr
 305                 310                 315                 320

 ccc ctg ggt ccc cgc agc ggg gag acg atg gag gga gcc gcg gag tcc     1008
 Pro Leu Gly Pro Arg Ser Gly Glu Thr Met Glu Gly Ala Ala Glu Ser
                 325                 330                 335

 ccg aag gcc gct gga tca gga agc gct cag acg ccc gcg cag ccc gaa     1056
 Pro Lys Ala Ala Gly Ser Gly Ser Ala Gln Thr Pro Ala Gln Pro Glu
             340                 345                 350

 gct ttg gcg cag ccc cgg ggg cgg ggc gcc agg agg tgg cag cct ccg     1104
 Ala Leu Ala Gln Pro Arg Gly Arg Gly Ala Arg Arg Trp Gln Pro Pro
         355                 360                 365

 agc gac agc gcg ccc agc caa cgg gac gcc ggc atg cgg cgc gcc gcc     1152
 Ser Asp Ser Ala Pro Ser Gln Arg Asp Ala Gly Met Arg Arg Ala Ala
     370                 375                 380

 ccg ccc ctc gct gcg cgg ccc aat ggt gaa cgc gcc ggc ttc ggg ctg     1200
 Pro Pro Leu Ala Ala Arg Pro Asn Gly Glu Arg Ala Gly Phe Gly Leu
 385                 390                 395                 400

 ggc ggt act ggg ctg gct gcg gtg gcg cgc ggg cgc ggc acc cgg aag     1248
 Gly Gly Thr Gly Leu Ala Ala Val Ala Arg Gly Arg Gly Thr Arg Lys
                 405                 410                 415

 tcg gcg gcg gtg gcg gag gcg acc tcg cga cct gtg tca gca gag ccg     1296
 Ser Ala Ala Val Ala Glu Ala Thr Ser Arg Pro Val Ser Ala Glu Pro
             420                 425                 430

 ccc tgc acc acc atg tgc atc atc ttc ttt aag ttt gat cct cgc cct     1344
 Pro Cys Thr Thr Met Cys Ile Ile Phe Phe Lys Phe Asp Pro Arg Pro
         435                 440                 445

 gtt tcc aaa aac gcg tac agg ctc atc ttg gca gcc aac agg gat gaa     1392
 Val Ser Lys Asn Ala Tyr Arg Leu Ile Leu Ala Ala Asn Arg Asp Glu
     450                 455                 460

 ttc tac agc cga ccc tcc aag tta gct gac ttc tgg ggg aac aac aac     1440
 Phe Tyr Ser Arg Pro Ser Lys Leu Ala Asp Phe Trp Gly Asn Asn Asn
 465                 470                 475                 480

 gag atc ctc agt ggg ctg gac atg gag gaa ggc aag gaa gga ggc aca     1488
 Glu Ile Leu Ser Gly Leu Asp Met Glu Glu Gly Lys Glu Gly Gly Thr
                 485                 490                 495

 tgg ctg ggc atc agc aca cgt ggc aag ctg gca gca ctc acc aac tac     1536
 Trp Leu Gly Ile Ser Thr Arg Gly Lys Leu Ala Ala Leu Thr Asn Tyr
             500                 505                 510

 ctg cag ccg cag ctg gac tgg cag gca cga ggg cga ggt gaa ctt gtc     1584
 Leu Gln Pro Gln Leu Asp Trp Gln Ala Arg Gly Arg Gly Glu Leu Val
         515                 520                 525

 acc cac ttt ctg acc act gac gtg gac agc ttg tcc tac ctg aag aag     1632
 Thr His Phe Leu Thr Thr Asp Val Asp Ser Leu Ser Tyr Leu Lys Lys
     530                 535                 540

 gtc tct atg gag ggc cat ctg tac aat ggc ttc aac ctc ata gca gcc     1680
 Val Ser Met Glu Gly His Leu Tyr Asn Gly Phe Asn Leu Ile Ala Ala
 545                 550                 555                 560

 gac ctg agc aca gca aag gga gac gtc att tgc tac tat ggg aac cga     1728
 Asp Leu Ser Thr Ala Lys Gly Asp Val Ile Cys Tyr Tyr Gly Asn Arg
                 565                 570                 575

 ggg gag cct gat cct atc gtt ttg acg cca ggc acc tac ggg ctg agc     1776
 Gly Glu Pro Asp Pro Ile Val Leu Thr Pro Gly Thr Tyr Gly Leu Ser
             580                 585                 590

 aac gcg ctg ctg gag act ccc tgg agg aag ctg tgc ttt ggg aag cag     1824
 Asn Ala Leu Leu Glu Thr Pro Trp Arg Lys Leu Cys Phe Gly Lys Gln
         595                 600                 605

 ctc ttc ctg gag gct gtg gaa cgg agc cag gcg ctg ccc aag gat gtg     1872
 Leu Phe Leu Glu Ala Val Glu Arg Ser Gln Ala Leu Pro Lys Asp Val
     610                 615                 620

 ctc atc gcc agc ctc ctg gat gtg ctc aac aat gaa gag gcg cag ctg     1920
 Leu Ile Ala Ser Leu Leu Asp Val Leu Asn Asn Glu Glu Ala Gln Leu
 625                 630                 635                 640

 cca gac ccg gcc atc gag gac cag ggt ggg gag tac gtg cag ccc atg     1968
 Pro Asp Pro Ala Ile Glu Asp Gln Gly Gly Glu Tyr Val Gln Pro Met
                 645                 650                 655

 ctg agc aag tac gcg gct gtg tgc gtg cgc tgc cct ggc tac ggc acc     2016
 Leu Ser Lys Tyr Ala Ala Val Cys Val Arg Cys Pro Gly Tyr Gly Thr
             660                 665                 670

 agg tat tgc agc acc gtg ggt gcg cca cct cct atc cca tgt ccc acc     2064
 Arg Tyr Cys Ser Thr Val Gly Ala Pro Pro Pro Ile Pro Cys Pro Thr
         675                 680                 685

 tcc cac gct aga ggg ccg gca aag aag cca agt gcc cat agc cag agc     2112
 Ser His Ala Arg Gly Pro Ala Lys Lys Pro Ser Ala His Ser Gln Ser
     690                 695                 700

 cag gct tct tcc tcg cct gag tgg att cca gag ctt ctg ccc tgt cca     2160
 Gln Ala Ser Ser Ser Pro Glu Trp Ile Pro Glu Leu Leu Pro Cys Pro
 705                 710                 715                 720

 gac gca gct gca gga acc aac act atc atc ctg gta gat gcg gac ggc     2208
 Asp Ala Ala Ala Gly Thr Asn Thr Ile Ile Leu Val Asp Ala Asp Gly
                 725                 730                 735

 cac gtg acc ttc act gag cgt agc atg atg gac aag gac ctc tcc cac     2256
 His Val Thr Phe Thr Glu Arg Ser Met Met Asp Lys Asp Leu Ser His
             740                 745                 750

 tgg gag acc aga acc tat gag ttc aca ctg cag agc taa                 2295
 Trp Glu Thr Arg Thr Tyr Glu Phe Thr Leu Gln Ser 
         755                 760





      <210> 113
      <211> 2411
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (124)..(1110)

      <400> 113
 tggaggttaa aaaaattaca gaaatcctta cctgtgttac tgagtagcaa tactatttat     60

 tatgtatgta ttttaaaggc attaacattt tttatttttc aggattaatt ggaattcttc    120

 aaa  atg tca ggt gtg gta ccc aca gcc cct gaa cag cct gca ggt gaa     168
      Met Ser Gly Val Val Pro Thr Ala Pro Glu Gln Pro Ala Gly Glu
        1               5                  10                  15

 atg gaa aat caa aca aaa cca cca gat cca agg cct gat gct cct cct      216
 Met Glu Asn Gln Thr Lys Pro Pro Asp Pro Arg Pro Asp Ala Pro Pro
                  20                  25                  30

 gaa tac aat tct cat ttt tta cca aga ccc cct gga aca gct gtc cct      264
 Glu Tyr Asn Ser His Phe Leu Pro Arg Pro Pro Gly Thr Ala Val Pro
              35                  40                  45

 cca cct act ggc tac cca gga ggc ttg cct atg gga tac tac agt cca      312
 Pro Pro Thr Gly Tyr Pro Gly Gly Leu Pro Met Gly Tyr Tyr Ser Pro
          50                  55                  60

 cag caa ccc agt acc ttc cct ttg tac cag cca gtt ggt ggt atc cat      360
 Gln Gln Pro Ser Thr Phe Pro Leu Tyr Gln Pro Val Gly Gly Ile His
      65                  70                  75

 cct gtc cgg tat cag cct ggc aaa tat cct atg cca aat cag tct gtt      408
 Pro Val Arg Tyr Gln Pro Gly Lys Tyr Pro Met Pro Asn Gln Ser Val
  80                  85                  90                  95

 cca ata aca tgg atg cca ggg cca act cct atg gca aac tgc cct cct      456
 Pro Ile Thr Trp Met Pro Gly Pro Thr Pro Met Ala Asn Cys Pro Pro
                 100                 105                 110

 ggt ctg gaa tac tta gtt cag ttg gac aac ata cat gtt ctt cag cat      504
 Gly Leu Glu Tyr Leu Val Gln Leu Asp Asn Ile His Val Leu Gln His
             115                 120                 125

 ttt gag cct ctg gaa atg atg aca tgt ttt gaa act aat aat aga tat      552
 Phe Glu Pro Leu Glu Met Met Thr Cys Phe Glu Thr Asn Asn Arg Tyr
         130                 135                 140

 gat att aaa aac aac tca gac cag atg gtt tac gtt gta acc gaa gac      600
 Asp Ile Lys Asn Asn Ser Asp Gln Met Val Tyr Val Val Thr Glu Asp
     145                 150                 155

 aca gat gac ttt acc agg aat gcc tat cgg aca cta agg ccc ttc gtc      648
 Thr Asp Asp Phe Thr Arg Asn Ala Tyr Arg Thr Leu Arg Pro Phe Val
 160                 165                 170                 175

 ctc cgg gtc act gat tgt atg ggc cga gaa atc atg aca atg cag aga      696
 Leu Arg Val Thr Asp Cys Met Gly Arg Glu Ile Met Thr Met Gln Arg
                 180                 185                 190

 ccc ttc aga tgc acc tgc tgt tgc ttc tgt tgc ccc tct gcc aga caa      744
 Pro Phe Arg Cys Thr Cys Cys Cys Phe Cys Cys Pro Ser Ala Arg Gln
             195                 200                 205

 gag ctg gag gtg cag tgt cct cct ggt gtc acc att ggc ttt gtt gcg      792
 Glu Leu Glu Val Gln Cys Pro Pro Gly Val Thr Ile Gly Phe Val Ala
         210                 215                 220

 gaa cat tgg aac ctg tgc agg gcg gtg tac agc atc caa aat gag aag      840
 Glu His Trp Asn Leu Cys Arg Ala Val Tyr Ser Ile Gln Asn Glu Lys
     225                 230                 235

 aaa gaa aat gtg atg aga gtt cgt ggg cca tgc tca acc tat ggc tgt      888
 Lys Glu Asn Val Met Arg Val Arg Gly Pro Cys Ser Thr Tyr Gly Cys
 240                 245                 250                 255

 ggt tca gat tct gtt ttt gag gtc aaa tcc ctt gat ggc ata tcc aac      936
 Gly Ser Asp Ser Val Phe Glu Val Lys Ser Leu Asp Gly Ile Ser Asn
                 260                 265                 270

 atc ggc agt att atc cgg aag tgg aat ggt ttg tta tca gca atg gca      984
 Ile Gly Ser Ile Ile Arg Lys Trp Asn Gly Leu Leu Ser Ala Met Ala
             275                 280                 285

 gat gct gac cat ttt gac att cac ttc cca cta gac ctg gat gtg aag     1032
 Asp Ala Asp His Phe Asp Ile His Phe Pro Leu Asp Leu Asp Val Lys
         290                 295                 300

 atg aaa gcc atg att ttt gga gct tgc ttc ctc att gac ttc atg tat     1080
 Met Lys Ala Met Ile Phe Gly Ala Cys Phe Leu Ile Asp Phe Met Tyr
     305                 310                 315

 ttt gaa aga tct cca cca caa cgt tca aga t agagagacac agcaagccat     1131
 Phe Glu Arg Ser Pro Pro Gln Arg Ser Arg 
 320                 325

 cacctatggt taattttgaa aaatggaaaa gttggattgg gcttacagtc agcactcagt   1191

 tatttgcaag tgtatttctt tgctttgtag agtattttta ttgggtgtta actttgacag   1251

 ctgagagtgg gcttgcaaga acacaatcta aaagtgtgtt tcaattgagt atctctctag   1311

 tagaatagga gttcatcctg aaaagctgtg actcattaac ccagtaaaca tatacaaagt   1371

 aagcttaaag cactataaac atgagataag ggaaaatgaa tccagagttc tcatattaat   1431

 aggtagtgaa acaataaggc tttttagagc agactttgtt ggcataaaat aacctggctt   1491

 ctatccctaa ccctttccta cctttcctct ccgtcaacat gtcctcatac tgaagacaaa   1551

 cttgtttcaa tgatagtctt cattttcaaa aacaaaaagg caggcagaca gaaataatga   1611

 tgttttcttg cactaagaag gtactacttg tacacatata tcaaaacctc attctgcaaa   1671

 gtttttgaag gtttcaatgg gaaatttgat tttattacaa aataaaacat tttttaatgt   1731

 taaagtttat atattccatg cttgttttct cattcactgg catggatgat caggagctgc   1791

 ctatatgtga aggcagaatc agactatcag gaaaggagct ggccagggcc acagccagtc   1851

 aagatctctg agcaacttag agacattggt gtcattatat gaagcttgca tttaatacat   1911

 ttatacataa tacatttgta catttaattc ataacgtctc ttggtcacag atgccttata   1971

 tataaaataa gttgccagat ctctaagatt gcctagtaca cctttgtatc tcatttgatg   2031

 tgatacccag aagagatcat tgttttttgt ttttgttttt gtttttttca agaagatcct   2091

 tcgtgatcac catgctgttc tcatggtaag aactggagtt atgtttttaa atttggaaat   2151

 atgacatttt atgtagcact ttataaaaag tgaaagcgac aaattccacc gctgcttaat   2211

 actgctttgc ttctttttat tgacatgata gataaatatg tatctacaca gagtaataat   2271

 aataaaacac agtaaacatt ctatttctct atggtctaca gcatgccagt aaataatatg   2331

 taggaccaat aataaattat caattacaca tttttgtgtt aactaattaa aagcatagtg   2391

 tataagtgaa aaaaaaaaaa                                               2411




      <210> 114
      <211> 2367
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1729)..(2085)

      <400> 114
 ttagtccaca ggtcgctttt ccccatattt ctttgtaaac tcttcagcat tcttacagaa     60

 ttttttacgg tccttagagt attcttcagc taggtcagcc cgaagcgggt gctcaggctg    120

 ggggtcattc accagtgcta tgagggactg gattacaggg tggagcgccg tgtcctccac    180

 cgacgtcaat gacgtgctga ggttcaccca ttcattcacc tgcgaatgct gcaccgactg    240

 gggaccgggc tcctcactgt tcttggaaaa gttcagcttg atcagggacc tcccgtccag    300

 cttctctcca ttgctggggt tggtcccgta cttcttaagc catggaacaa tgttcagtaa    360

 gtcaaagacg atgccatcgg gagtgcagac tggcttcttg ccaccataaa agtgagtgta    420

 ttcagcacag gtaatgtaca ttttgtcctt ttggtgctgt cgcttcccca tggcggagcg    480

 gcggcggcga aattgagacc tgttgctgtt gggcccggag ttggccatgc tgaggatgcc    540

 gcggcccgtg tgcgagaggt tgggccggaa ctcgtctttg aagggcttcc cccagtatga    600

 ctccccaccc gtgcctgtgc ctgtggggtc gcccccttgg atcacaaagt tccggatgga    660

 tctgtggaag atggtgccat cgtaataatg cttcttgcaa agcctgatga agttttcgca    720

 ggtttttggt gtctgtgcgc aggccatgct gccaacgcgg ccccctagga aggacacagg    780

 gcactgctgc gggtcccgcc tagtgacagg ctgaatttcc agtggcagcc ctatatttaa    840

 gacatggctg tcagatgacc cagagatgac cttggggcat ggggagtggc tggcctccac    900

 acccaccagg tcgcagtgca gctccaggtt gaggtcgccc ttgttggtgt gcagccgcac    960

 gtagcccttc ttcttcacaa actggtagcg cagcacatcc tcgtcgatgg cagctgcttc   1020

 atgtgtggtc tccgggacca tcgcggtgga ggtgaaggaa gcgctgacct tccctgtgga   1080

 atagtgggca gcattcagct tgtccacttt cttcttctcc ggggccttca tggtggctgc   1140

 cagaatctcg tcccctttga actccttgta gagctcctgc agggtctctc gggtctcggc   1200

 atttgtattt ttcagataat aagacgggtc ctgtttggcc ttctcttcat ctgggtctat   1260

 tattttcatg ttattcttca catgatagaa gttagagaca ttgaacttgt ccaaattggt   1320

 ggggtcctgg agggtgatga tgtcctgccg ggagaagggc tcgtcggtca gcaggtcccg   1380

 gaagttcttg gccttgatat ttagctgttc cactgcctca taggcgtaga cgttgccggt   1440

 cgtcctcaca gccacgatgt gggtgttgtt ggtgaacacg gtaaacagca ctgggcagtg   1500

 gtacttccct gcttcacacg catgttctct ctgtaaccca ccactttgtc tgattggttg   1560

 gcaggttacg tttttctctc gtcccagctg tgtggacagt gccacacgcc ctcctggaca   1620

 acgacggctc ttgcgtgcat tttccagtgt tgcttttgtc agagaggcca gcagagccac   1680

 ggttcttcca gaaccagccc tgagctgagt gaggagtgcc caggagag atg gtg aaa    1737
                                                      Met Val Lys
                                                        1

 atg aca aag tcc aaa act ttc caa gcg tat ctg ccg aac tgt cac cga     1785
 Met Thr Lys Ser Lys Thr Phe Gln Ala Tyr Leu Pro Asn Cys His Arg
       5                  10                  15

 acg tac agc tgt atc cac tgc aga gca cac ctg gcc aat cat gac gag     1833
 Thr Tyr Ser Cys Ile His Cys Arg Ala His Leu Ala Asn His Asp Glu
  20                  25                  30                  35

 ctc atc tcc aag tcc ttt cag ggg agc cag gga cgc gcc tac ctc ttc     1881
 Leu Ile Ser Lys Ser Phe Gln Gly Ser Gln Gly Arg Ala Tyr Leu Phe
                  40                  45                  50

 aat tcc gtg gtg aac gtg ggc tgc ggc cct gca gag gag agg gtc ctt     1929
 Asn Ser Val Val Asn Val Gly Cys Gly Pro Ala Glu Glu Arg Val Leu
              55                  60                  65

 ctc acc ggg ctg cat gcg gtt gcc gac atc tac tgc gag aac tgc aag     1977
 Leu Thr Gly Leu His Ala Val Ala Asp Ile Tyr Cys Glu Asn Cys Lys
          70                  75                  80

 acc acg ctc ggg tgg aaa tac gag cat gcc ttt gag agc agt cag aaa     2025
 Thr Thr Leu Gly Trp Lys Tyr Glu His Ala Phe Glu Ser Ser Gln Lys
      85                  90                  95

 tat aag gaa gga aaa ttc atc att gag ctt gct cat atg atc aaa gac     2073
 Tyr Lys Glu Gly Lys Phe Ile Ile Glu Leu Ala His Met Ile Lys Asp
 100                 105                 110                 115

 aat ggc tgg gag taa tgtgcgaact ttcccttctc cttcgaatgc tgttttgtga     2128
 Asn Gly Trp Glu 


 aagaaactgt gaatgtaatg gaaacgtagg agcatctggt gacagccttt cttgccctct   2188

 gacctcaaag gctagctgcg catagctctt gacactctcg gccatctctg tgggtaaggt   2248

 gtccctcgga tctgtcctct tcgtgtacac agttgtttct gaaaattttc aatgagcttt   2308

 ttctaacttc tcaagttcta gagaaagaat taaccaactg atgacttaaa aaaaaaaaa    2367




      <210> 115
      <211> 9870
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (3442)..(9387)

      <400> 115
 atggcacgat cacagctcac tgtagtcttg acctcctggg ctcaggcgat tctcctgctt     60

 cagcctctcg aggagctggg cccacaggaa ctgggtggca tagcaggagg tgagcagcag    120

 gcaagccagc attacccgct gagctccgct tcctgtcaga tcagaggcaa cgctgattct    180

 cataggagca cggatcctac tgtgaacagc ccatgcgaag gatctaggtt gtgcggcact    240

 cccaagaatc taacgcctga tgatgttcac ttatgtagtt cccatttgtt acttcgacga    300

 gcagctgtgg catgtcttcg gcaacttgca caaagagaag cagcggaagt atgtgaatat    360

 gccatgagcc tggcaaaaaa tacaggggac aaagagagca gtagtgccaa tgtcagtcct    420

 tttgcccctg gggttagttc tcgaactgat atccattgcc ggcaccaagg tgttaatata    480

 acagaaactg gtcttgaggg acttcttttt ggaatgctag accgggagac agatcgaaaa    540

 ttatgttctg atattcatga cactttggga catatgcttt cttcgctggc agtagaaaaa    600

 ctttctcatt ggctaatgct ttgtaaagat gtcctggcag cttctagtga tatgagtact    660

 gcaactctct taagtagtgg aaaagatgaa gaagctgaaa agaaagatga gatggatgat    720

 gataccatgt ttaccacgtt aggtgaagaa gataaatcaa agccctttgt ggcccctcgc    780

 tgggccactc gagtatttgc tgccgattgc ctgtgtcgaa tcatcaattt gtgtgagaat    840

 gcagaccagg ctcactttga tcttgccttg gcacgttctg ctaaacttcg aaaccctaca    900

 aatgacctct tggtacttca tctctctgac ctcattcgca tggcattcat ggctgcaact    960

 gatcatagca accagctgcg aatggctggg ctccaggcgc ttgaagacat tatcaagaag   1020

 tttgcgtctg tgcctgagcc agaatttcca ggtcatgtga tactggagca gtatcaggct   1080

 aatgtgggag ctgctctaag accagccttt tcacaagata caccatcaga tataatagcg   1140

 aaagcttgcc aggtatgtag tacatggata ggaagtggag ttgtcagtga tctcaatgat   1200

 ctccgtcgag tacacaatct tcttgtttct tctctggaca aagttcaggc tggaaaagga   1260

 tcttccagcc agctgtaccg agagagtgcc acgaccatgg aaaaactggc tgttctcaaa   1320

 gcttgggcag aggtatatgt ggtcgctatg aatattaaaa aggaagcaga gtcaaaacca   1380

 aaaagagcaa ttaaaaatac tgacgatgat gatgacgact gtggtaccat cgatgaactg   1440

 ccaccagata gtttaataac actggtacaa cctgaactac caacactcag tcgcctgtgg   1500

 ttagcagcat taaaagatta tgcactcttg actttaccag ccgaattttc tagtcagctt   1560

 cctccagatg caaggagtga tgaggaagtc ctcagtgtta gtagaggaaa caacaggagg   1620

 tggagaggaa tagcagaaga agaaagaaac agagggaaga aacagagttc cctggttgtg   1680

 atagaaagag aagatgatag ggttttagga gccactggca acaatgaaga ggtaaattct   1740

 gtgacaacag gacctgagga gcccattgaa catgttacag catgcctgca ggccttacat   1800

 accttgctag actcccctta tgctcgagtc catattgcag aagatcagct gataggtgtt   1860

 gagttgctga gtgttttgca ccgccttcta ttgacctgga atccatcatc tgtccagctg   1920

 ttggttactg gagttgtaca acagatagta agagctgctc aggattattt gcaagagaaa   1980

 agaaacactc taaatgaaga tgatatggaa aaagaggcct gtaccgtatt gggagaagga   2040

 ggtgacagcg gtggtctcat tcctggaaaa tctcttgtgt ttgcaactat ggagctgctg   2100

 atgttcattt tagtacggca tatgccacat ctcagtacca aggtgtcaga ctctccaagt   2160

 cacatagcca ctaaaactcg actatcagaa gaaagtgctc gtttggtggc agccacagtt   2220

 accatactct ctgatttacc atccctttgt tcacccgctg agttacccta catatgtgaa   2280

 aataatgaat tctccatatt tggagttttg caagcagagg ctacaatggc tgcaggtcag   2340

 agtggtgaag gatgtatgac aatcctgccc acaattctgt tcttaattgc aagaatattg   2400

 aaagacacag caataaagtc tgcagataat caggttcctc caccagtcag tgcagctctt   2460

 caagggatta aaagtattgt gacactttca atggccaaaa ctgaggctgg cgttcaaaaa   2520

 cagtggacag ctctgattcg tagcacgctt gcttgcatcc tggaatattc tcaaccagaa   2580

 gactctgtac ctacacctga tgaagtaagc atgctaacag caattgcact cttcctgtgg   2640

 tctgctagta atgaaataat aggagtccag tcattacaga atggctgcat gaacagattt   2700

 aaaaatgcat taaattcatg cgacccatgg gttcaagcca aatgttacca gcttctcctc   2760

 tcagtcttcc agcattccaa tcgtgccctt tcaactcctt atattcattc attagctcca   2820

 atagtggttg aaaagctaaa agctgttgaa agaaacagac cagccagtaa catagagctt   2880

 ttagcggttc aagaaggaat aaaagttctt gaaacactgg ttgctcttgg tgaagaacaa   2940

 aacagagtcc agctacttgc tcttttagtt cccactttga tatcttacct gctggatgaa   3000

 aattcttttg cctcagcaag ttcagcttcc aaagatcttc atgagtttgc actccagaat   3060

 ttaatgcata ttggacctct gtatccacat gctttcaaga cagtaatggg ggctgctcct   3120

 gagttgaaaa ggtttccact ggttacttgg tgtgcgccct atgtaaatga agaggatgaa   3180

 gtaaagttac aacgtcattt agttggtgtg cgccctatga tttactgcag gaggactgca   3240

 aagggaaaga aacttcaacg gagcagtttt tcagatgggc tgtcaacaaa ccacaatttg   3300

 gaagcagcag cagaaagctg cggcgttgtc ttagaaaggt gatcggcgtt ccttagaaat   3360

 gaaaactggt caggtaacag gtttgagccc ctcgagtcaa aagagaaagg caagagcgac   3420

 agcgactcgc agattggcag a  atg gag gag cgt cta ggg agg ctg ctc cct    3471
                          Met Glu Glu Arg Leu Gly Arg Leu Leu Pro
                            1               5                  10

 gct gac tgg ggt gtg ggc ggg acg gcg gag gga gga gga ggc gct gct     3519
 Ala Asp Trp Gly Val Gly Gly Thr Ala Glu Gly Gly Gly Gly Ala Ala
                  15                  20                  25

 tgc cgc cgc tgt tgc ctc cgc tgc tgg gcg ccg ggg cag ctc ccc ggt     3567
 Cys Arg Arg Cys Cys Leu Arg Cys Trp Ala Pro Gly Gln Leu Pro Gly
              30                  35                  40

 act ctg cgg ccg cca tgg acg agc agg cgt gtc acg gcg tct tct tca     3615
 Thr Leu Arg Pro Pro Trp Thr Ser Arg Arg Val Thr Ala Ser Ser Ser
          45                  50                  55

 gca aca acc acc cgg gcg ccg cgg tgc aag gtg ctc tgg gct ctg cgg     3663
 Ala Thr Thr Thr Arg Ala Pro Arg Cys Lys Val Leu Trp Ala Leu Arg
      60                  65                  70

 agt gct gcc gcg gcc gcg acg ggc gct gcg tgg tat gct tca ttg cct     3711
 Ser Ala Ala Ala Ala Ala Thr Gly Ala Ala Trp Tyr Ala Ser Leu Pro
  75                  80                  85                  90

 gat gtc cag tgt ctt gaa aac tgt tgt ttc att tat ttt gtc gag ttt     3759
 Asp Val Gln Cys Leu Glu Asn Cys Cys Phe Ile Tyr Phe Val Glu Phe
                  95                 100                 105

 ttt ggt tat ctc agg aga ggt gaa cta cag aat gaa gct gta ttt atg     3807
 Phe Gly Tyr Leu Arg Arg Gly Glu Leu Gln Asn Glu Ala Val Phe Met
             110                 115                 120

 tgg act gct gaa cta gaa aat ata gcc act ctc tgc ttt aag gct ttg     3855
 Trp Thr Ala Glu Leu Glu Asn Ile Ala Thr Leu Cys Phe Lys Ala Leu
         125                 130                 135

 gaa aac tca aat tat ggg gta cga gtg gca gtg tct aaa ctt tta gga     3903
 Glu Asn Ser Asn Tyr Gly Val Arg Val Ala Val Ser Lys Leu Leu Gly
     140                 145                 150

 aca gtc atg gcc aca gca tta atg cca aaa cag gca aca gta atg cgt     3951
 Thr Val Met Ala Thr Ala Leu Met Pro Lys Gln Ala Thr Val Met Arg
 155                 160                 165                 170

 cag aat gtg aag cga gca aca ttt gat gaa gtc tta gaa ctc atg gcc     3999
 Gln Asn Val Lys Arg Ala Thr Phe Asp Glu Val Leu Glu Leu Met Ala
                 175                 180                 185

 aca gga ttt ctg cgt gga ggg tca ggt ttc tta aag agc ggt gga gaa     4047
 Thr Gly Phe Leu Arg Gly Gly Ser Gly Phe Leu Lys Ser Gly Gly Glu
             190                 195                 200

 atg tta aaa gtt gga ggg tcc gtt aat cgt gaa gtg aga gtt gga gtt     4095
 Met Leu Lys Val Gly Gly Ser Val Asn Arg Glu Val Arg Val Gly Val
         205                 210                 215

 acg cag gcg tat gtt gtt ttt gtg aca aca ttg ggt ggt cag tgg ttg     4143
 Thr Gln Ala Tyr Val Val Phe Val Thr Thr Leu Gly Gly Gln Trp Leu
     220                 225                 230

 gag cgc agc ttt gcc acg ttc ctg tcc cat gta ctt gat ctg gtt tcc     4191
 Glu Arg Ser Phe Ala Thr Phe Leu Ser His Val Leu Asp Leu Val Ser
 235                 240                 245                 250

 cat cct cgg gca aca caa aca cat gtg gag gct gtg tac tcc aga cga     4239
 His Pro Arg Ala Thr Gln Thr His Val Glu Ala Val Tyr Ser Arg Arg
                 255                 260                 265

 tgt gtt tcc ttt atc cta aga gct act gtg ggc agt ttg cta ggt gaa     4287
 Cys Val Ser Phe Ile Leu Arg Ala Thr Val Gly Ser Leu Leu Gly Glu
             270                 275                 280

 aaa gcc cag att gca gct gcc aaa gaa atc tgc caa gct att gga aaa     4335
 Lys Ala Gln Ile Ala Ala Ala Lys Glu Ile Cys Gln Ala Ile Gly Lys
         285                 290                 295

 caa atg aaa gcc gta gaa gca gta gtg aat gac aca agt gga gaa aac     4383
 Gln Met Lys Ala Val Glu Ala Val Val Asn Asp Thr Ser Gly Glu Asn
     300                 305                 310

 aaa ttt ggc gca gca gac att gca gca agc cag cat gtg atg gtc tgt     4431
 Lys Phe Gly Ala Ala Asp Ile Ala Ala Ser Gln His Val Met Val Cys
 315                 320                 325                 330

 gcc ctc cag gaa ctc ggg agc ctg gtg cag agc ttg aat gcc acc gca     4479
 Ala Leu Gln Glu Leu Gly Ser Leu Val Gln Ser Leu Asn Ala Thr Ala
                 335                 340                 345

 tcc cct ctt att caa gaa gca tct ata ggg ctt ttg gag att gtg act     4527
 Ser Pro Leu Ile Gln Glu Ala Ser Ile Gly Leu Leu Glu Ile Val Thr
             350                 355                 360

 tca gtg ctg ctt cat cca agc atg gct gcc cga ctt gct gct gca tgg     4575
 Ser Val Leu Leu His Pro Ser Met Ala Ala Arg Leu Ala Ala Ala Trp
         365                 370                 375

 tgt ttg cgc tgt gtg gct gtg gca tta cct ttc cag ctg aca cca ttt     4623
 Cys Leu Arg Cys Val Ala Val Ala Leu Pro Phe Gln Leu Thr Pro Phe
     380                 385                 390

 cta gac agg tgt gca gaa cgg ctc aac aac ttg aag acc tca cca gaa     4671
 Leu Asp Arg Cys Ala Glu Arg Leu Asn Asn Leu Lys Thr Ser Pro Glu
 395                 400                 405                 410

 gct gtc agt gga tat agt ttt gca atg gct gct ttg tta ggt gga gta     4719
 Ala Val Ser Gly Tyr Ser Phe Ala Met Ala Ala Leu Leu Gly Gly Val
                 415                 420                 425

 cat cag tgt cct ttg ggc att cct cat gcc aaa gga aag atg gta gtt     4767
 His Gln Cys Pro Leu Gly Ile Pro His Ala Lys Gly Lys Met Val Val
             430                 435                 440

 agt att gct gaa gat ctt tta cga act gct gcc caa aat agc agg cta     4815
 Ser Ile Ala Glu Asp Leu Leu Arg Thr Ala Ala Gln Asn Ser Arg Leu
         445                 450                 455

 tct tta cag cgc acc caa gct ggc tgg ctt tta ctt gga gca ctt atg     4863
 Ser Leu Gln Arg Thr Gln Ala Gly Trp Leu Leu Leu Gly Ala Leu Met
     460                 465                 470

 act tta gga cca tct gtc gtt cgt tac cat ctg ccc aag atg ttg tta     4911
 Thr Leu Gly Pro Ser Val Val Arg Tyr His Leu Pro Lys Met Leu Leu
 475                 480                 485                 490

 ttg tgg cga aat gtt ttc cca cgt tcc tta aag gaa ttg gaa gct gag     4959
 Leu Trp Arg Asn Val Phe Pro Arg Ser Leu Lys Glu Leu Glu Ala Glu
                 495                 500                 505

 aag gcc cga ggc gat tct ttt acc tgg cag gta act ttg gaa ggt cgt     5007
 Lys Ala Arg Gly Asp Ser Phe Thr Trp Gln Val Thr Leu Glu Gly Arg
             510                 515                 520

 gct gga gct cta tgt gcc atg agg agc ttc gtt gca cat tgt cct gag     5055
 Ala Gly Ala Leu Cys Ala Met Arg Ser Phe Val Ala His Cys Pro Glu
         525                 530                 535

 cta cta act gaa gat gtg att cga aaa ttg atg acc cct att gaa tgt     5103
 Leu Leu Thr Glu Asp Val Ile Arg Lys Leu Met Thr Pro Ile Glu Cys
     540                 545                 550

 gcc atg act atg atg tca cac att cca tct gta atg aaa gcc cat gga     5151
 Ala Met Thr Met Met Ser His Ile Pro Ser Val Met Lys Ala His Gly
 555                 560                 565                 570

 gct cat ctg aaa gct agt gct gca atg gtc cgt tta aga ctt tat gat     5199
 Ala His Leu Lys Ala Ser Ala Ala Met Val Arg Leu Arg Leu Tyr Asp
                 575                 580                 585

 atc ttg gct ttg tta cct cca aaa act tat gaa gga tct ttt aat gca     5247
 Ile Leu Ala Leu Leu Pro Pro Lys Thr Tyr Glu Gly Ser Phe Asn Ala
             590                 595                 600

 ctt ctt aga gaa ctg gta gcg gaa ttc act ttg act gac aac tca gcc     5295
 Leu Leu Arg Glu Leu Val Ala Glu Phe Thr Leu Thr Asp Asn Ser Ala
         605                 610                 615

 aac aca act act tcc ctc ctc aga tcc ctc tgc cat tat gat gat agt     5343
 Asn Thr Thr Thr Ser Leu Leu Arg Ser Leu Cys His Tyr Asp Asp Ser
     620                 625                 630

 gtt ctt ctt ggt tct tgg ctt cag gaa act gat cat aaa tca att gaa     5391
 Val Leu Leu Gly Ser Trp Leu Gln Glu Thr Asp His Lys Ser Ile Glu
 635                 640                 645                 650

 gac cag ctc cag cca aac agt gcc tct gga agt ggg gct ctg gag cat     5439
 Asp Gln Leu Gln Pro Asn Ser Ala Ser Gly Ser Gly Ala Leu Glu His
                 655                 660                 665

 gat cct tcc tct att tat tta cgc ata cct gct gga gaa gca gta cct     5487
 Asp Pro Ser Ser Ile Tyr Leu Arg Ile Pro Ala Gly Glu Ala Val Pro
             670                 675                 680

 ggt ccc ctc cct ctc gga gtc tca gtc att gat gct tct gtg gcc ctt     5535
 Gly Pro Leu Pro Leu Gly Val Ser Val Ile Asp Ala Ser Val Ala Leu
         685                 690                 695

 ttt ggt gta gtg ttt cct cat gtt tct tat aaa cac cga tta caa atg     5583
 Phe Gly Val Val Phe Pro His Val Ser Tyr Lys His Arg Leu Gln Met
     700                 705                 710

 ttg gat cac ttt gct gaa tgt gtt aaa caa gct aaa ggt gtc cgc cag     5631
 Leu Asp His Phe Ala Glu Cys Val Lys Gln Ala Lys Gly Val Arg Gln
 715                 720                 725                 730

 cag gct gtg cag ctt aac ata ttt act gct gtt ctt agt gca cta aag     5679
 Gln Ala Val Gln Leu Asn Ile Phe Thr Ala Val Leu Ser Ala Leu Lys
                 735                 740                 745

 ggc tta gct gaa aac aaa agt act tta gga cct gag gaa gtt cgt aaa     5727
 Gly Leu Ala Glu Asn Lys Ser Thr Leu Gly Pro Glu Glu Val Arg Lys
             750                 755                 760

 tct gcc ctg aca ctg gtt atg ggt cct ctg gac aac cca aac ccc atc     5775
 Ser Ala Leu Thr Leu Val Met Gly Pro Leu Asp Asn Pro Asn Pro Ile
         765                 770                 775

 tta cgt tgt gca gcg ggg gaa gct ctt gga aga atg gct cag gtg gtt     5823
 Leu Arg Cys Ala Ala Gly Glu Ala Leu Gly Arg Met Ala Gln Val Val
     780                 785                 790

 gga gaa gca act ttt att gct aga atg gcc caa tat agc ttt gac aag     5871
 Gly Glu Ala Thr Phe Ile Ala Arg Met Ala Gln Tyr Ser Phe Asp Lys
 795                 800                 805                 810

 ttg aaa tcg gct cga gat gtt gta tct agg act ggt cat tca ttg gct     5919
 Leu Lys Ser Ala Arg Asp Val Val Ser Arg Thr Gly His Ser Leu Ala
                 815                 820                 825

 ctt ggt tgt ttg cat cgt tat gtt ggt gga ata ggc tca gga caa cat     5967
 Leu Gly Cys Leu His Arg Tyr Val Gly Gly Ile Gly Ser Gly Gln His
             830                 835                 840

 ctg aag acc agt gtc agc att tta ttg gct cta gca caa gat ggg aca     6015
 Leu Lys Thr Ser Val Ser Ile Leu Leu Ala Leu Ala Gln Asp Gly Thr
         845                 850                 855

 tcc cct gaa gtc cag act tgg tct ctt cat tca ctt gct ttg ata gtg     6063
 Ser Pro Glu Val Gln Thr Trp Ser Leu His Ser Leu Ala Leu Ile Val
     860                 865                 870

 gat tct agt ggt ccg atg tat cgt ggc tat gtg gaa cca aca tta tct     6111
 Asp Ser Ser Gly Pro Met Tyr Arg Gly Tyr Val Glu Pro Thr Leu Ser
 875                 880                 885                 890

 cta gtt ctt acc ttg ctg ttg aca gtt ccg cct tca cat aca gaa gtt     6159
 Leu Val Leu Thr Leu Leu Leu Thr Val Pro Pro Ser His Thr Glu Val
                 895                 900                 905

 cat cag tgt ttg ggt cga tgc ttg ggt gct ata ata act act gtt ggc     6207
 His Gln Cys Leu Gly Arg Cys Leu Gly Ala Ile Ile Thr Thr Val Gly
             910                 915                 920

 cct gaa cta caa ggg aat gga gca aca act tct aca att cgt tcc tct     6255
 Pro Glu Leu Gln Gly Asn Gly Ala Thr Thr Ser Thr Ile Arg Ser Ser
         925                 930                 935

 tgt ttg gtg ggt tgt gca ata aca caa gac cat tca gat tct ctt gtt     6303
 Cys Leu Val Gly Cys Ala Ile Thr Gln Asp His Ser Asp Ser Leu Val
     940                 945                 950

 cag gca gct gcc ata tct tgc ctt cag cag ctt cac atg ttt gca cca     6351
 Gln Ala Ala Ala Ile Ser Cys Leu Gln Gln Leu His Met Phe Ala Pro
 955                 960                 965                 970

 cga cat gtc aat cta tct agc ctt gtt cct agc ctt tgt gtt cac tta     6399
 Arg His Val Asn Leu Ser Ser Leu Val Pro Ser Leu Cys Val His Leu
                 975                 980                 985

 tgt agt tcc cat ttg tta ctt cga cga gca gct gtg gca tgt ctt cgg     6447
 Cys Ser Ser His Leu Leu Leu Arg Arg Ala Ala Val Ala Cys Leu Arg
             990                 995                1000

 caa ctt gca caa aga gaa gca gcg gaa gta tgt gaa tat gcc atg agc     6495
 Gln Leu Ala Gln Arg Glu Ala Ala Glu Val Cys Glu Tyr Ala Met Ser
        1005                1010                1015

 ctg gca aaa aat aca ggg gac aaa gag agc agt agt gcc aat gtc agt     6543
 Leu Ala Lys Asn Thr Gly Asp Lys Glu Ser Ser Ser Ala Asn Val Ser
    1020                1025                1030

 cct ttt gcc cct ggg gtt agt tct cga act gat atc cat tgc cgg cac     6591
 Pro Phe Ala Pro Gly Val Ser Ser Arg Thr Asp Ile His Cys Arg His
1035                1040                1045                1050

 caa ggt gtt aat ata aca gaa act ggt ctt gag gga ctt ctt ttt gga     6639
 Gln Gly Val Asn Ile Thr Glu Thr Gly Leu Glu Gly Leu Leu Phe Gly
                1055                1060                1065

 atg cta gac cgg gag aca gat cga aaa tta tgt tct gat att cat gac     6687
 Met Leu Asp Arg Glu Thr Asp Arg Lys Leu Cys Ser Asp Ile His Asp
            1070                1075                1080

 act ttg gga cat atg ctt tct tcg ctg gca gta gaa aaa ctt tct cat     6735
 Thr Leu Gly His Met Leu Ser Ser Leu Ala Val Glu Lys Leu Ser His
        1085                1090                1095

 tgg cta atg ctt tgt aaa gat gtc ctg gca gct tct agt gat atg agt     6783
 Trp Leu Met Leu Cys Lys Asp Val Leu Ala Ala Ser Ser Asp Met Ser
    1100                1105                1110

 act gca act ctc tta agt agt gga aaa gat gaa gaa gct gaa aag aaa     6831
 Thr Ala Thr Leu Leu Ser Ser Gly Lys Asp Glu Glu Ala Glu Lys Lys
1115                1120                1125                1130

 gat gag atg gat gat gat acc atg ttt acc acg tta ggt gaa gaa gat     6879
 Asp Glu Met Asp Asp Asp Thr Met Phe Thr Thr Leu Gly Glu Glu Asp
                1135                1140                1145

 aaa tca aag ccc ttt gtg gcc cct cgc tgg gcc act cga gta ttt gct     6927
 Lys Ser Lys Pro Phe Val Ala Pro Arg Trp Ala Thr Arg Val Phe Ala
            1150                1155                1160

 gcc gat tgc ctg tgt cga atc atc aat ttg tgt gag aat gca gac cag     6975
 Ala Asp Cys Leu Cys Arg Ile Ile Asn Leu Cys Glu Asn Ala Asp Gln
        1165                1170                1175

 gct cac ttt gat ctt gcc ttg gca cgt tct gct aaa ctt cga aac cct     7023
 Ala His Phe Asp Leu Ala Leu Ala Arg Ser Ala Lys Leu Arg Asn Pro
    1180                1185                1190

 aca aat gac ctc ttg gta ctt cat ctc tct gac ctc att cgc atg gca     7071
 Thr Asn Asp Leu Leu Val Leu His Leu Ser Asp Leu Ile Arg Met Ala
1195                1200                1205                1210

 ttc atg gct gca act gat cat agc aac cag ctg cga atg gct ggg ctc     7119
 Phe Met Ala Ala Thr Asp His Ser Asn Gln Leu Arg Met Ala Gly Leu
                1215                1220                1225

 cag gcg ctt gaa gac att atc aag aag ttt gcg tct gtg cct gag cca     7167
 Gln Ala Leu Glu Asp Ile Ile Lys Lys Phe Ala Ser Val Pro Glu Pro
            1230                1235                1240

 gaa ttt cca ggt cat gtg ata ctg gag cag tat cag gct aat gtg gga     7215
 Glu Phe Pro Gly His Val Ile Leu Glu Gln Tyr Gln Ala Asn Val Gly
        1245                1250                1255

 gct gct cta aga cca gcc ttt tca caa gat aca cca tca gat ata ata     7263
 Ala Ala Leu Arg Pro Ala Phe Ser Gln Asp Thr Pro Ser Asp Ile Ile
    1260                1265                1270

 gcg aaa gct tgc cag gta tgt agt aca tgg ata gga agt gga gtt gtc     7311
 Ala Lys Ala Cys Gln Val Cys Ser Thr Trp Ile Gly Ser Gly Val Val
1275                1280                1285                1290

 agt gat ctc aat gat ctc cgt cga gta cac aat ctt ctt gtt tct tct     7359
 Ser Asp Leu Asn Asp Leu Arg Arg Val His Asn Leu Leu Val Ser Ser
                1295                1300                1305

 ctg gac aaa gtt cag gct gga aaa gga tct tcc agc cag ctg tac cga     7407
 Leu Asp Lys Val Gln Ala Gly Lys Gly Ser Ser Ser Gln Leu Tyr Arg
            1310                1315                1320

 gag agt gcc acg acc atg gaa aaa ctg gct gtt ctc aaa gct tgg gca     7455
 Glu Ser Ala Thr Thr Met Glu Lys Leu Ala Val Leu Lys Ala Trp Ala
        1325                1330                1335

 gag gta tat gtg gtc gct atg aat att aaa aag gaa gca gag tca aaa     7503
 Glu Val Tyr Val Val Ala Met Asn Ile Lys Lys Glu Ala Glu Ser Lys
    1340                1345                1350

 cca aaa aga gca att aaa aat act gac gat gat gat gac gac tgt ggt     7551
 Pro Lys Arg Ala Ile Lys Asn Thr Asp Asp Asp Asp Asp Asp Cys Gly
1355                1360                1365                1370

 acc atc gat gaa ctg cca cca gat agt tta ata aca ctg gta caa cct     7599
 Thr Ile Asp Glu Leu Pro Pro Asp Ser Leu Ile Thr Leu Val Gln Pro
                1375                1380                1385

 gaa cta cca aca ctc agt cgc ctg tgg tta gca gca tta aaa gat tat     7647
 Glu Leu Pro Thr Leu Ser Arg Leu Trp Leu Ala Ala Leu Lys Asp Tyr
            1390                1395                1400

 gca ctc ttg act tta cca gcc gaa ttt tct agt cag ctt cct cca gat     7695
 Ala Leu Leu Thr Leu Pro Ala Glu Phe Ser Ser Gln Leu Pro Pro Asp
        1405                1410                1415

 ggt gga gca ttt tat acc cct gaa act att gat aca gct aga ctt cac     7743
 Gly Gly Ala Phe Tyr Thr Pro Glu Thr Ile Asp Thr Ala Arg Leu His
    1420                1425                1430

 tat cgg aat tcc tgg gcc cca att ctc cat gcg gtg gca ctt tgg tta     7791
 Tyr Arg Asn Ser Trp Ala Pro Ile Leu His Ala Val Ala Leu Trp Leu
1435                1440                1445                1450

 aat agc aca gga ttt acg tgc tca gag tct aca gaa gca gca gca ata     7839
 Asn Ser Thr Gly Phe Thr Cys Ser Glu Ser Thr Glu Ala Ala Ala Ile
                1455                1460                1465

 tct ggt tta caa aaa cgt tct aca tct gtc aat tta aac cag gca tca     7887
 Ser Gly Leu Gln Lys Arg Ser Thr Ser Val Asn Leu Asn Gln Ala Ser
            1470                1475                1480

 gga gca gtg ggt agt gct aaa tct ttg cca gaa att aac aaa gac aga     7935
 Gly Ala Val Gly Ser Ala Lys Ser Leu Pro Glu Ile Asn Lys Asp Arg
        1485                1490                1495

 atg cat ctg att tta ggt gtg agt ata cag ttt ctt tgt tcc cct aga     7983
 Met His Leu Ile Leu Gly Val Ser Ile Gln Phe Leu Cys Ser Pro Arg
    1500                1505                1510

 cct gag gag ccc att gaa cat gtt aca gca tgc ctg cag gcc tta cat     8031
 Pro Glu Glu Pro Ile Glu His Val Thr Ala Cys Leu Gln Ala Leu His
1515                1520                1525                1530

 acc ttg cta gac tcc cct tat gct cga gtc cat att gca gaa gat cag     8079
 Thr Leu Leu Asp Ser Pro Tyr Ala Arg Val His Ile Ala Glu Asp Gln
                1535                1540                1545

 ctg ata ggt gtt gag ttg ctg agt gtt ttg cac cgc ctt cta ttg acc     8127
 Leu Ile Gly Val Glu Leu Leu Ser Val Leu His Arg Leu Leu Leu Thr
            1550                1555                1560

 tgg aat cca tca tct gtc cag ctg ttg gtt act gga gtt gta caa cag     8175
 Trp Asn Pro Ser Ser Val Gln Leu Leu Val Thr Gly Val Val Gln Gln
        1565                1570                1575

 ata gta aga gct gct cag gat tat ttg caa gag aaa aga aac act cta     8223
 Ile Val Arg Ala Ala Gln Asp Tyr Leu Gln Glu Lys Arg Asn Thr Leu
    1580                1585                1590

 aat gaa gat gat atg gaa aaa gag gcc tgt acc gta ttg gga gaa gga     8271
 Asn Glu Asp Asp Met Glu Lys Glu Ala Cys Thr Val Leu Gly Glu Gly
1595                1600                1605                1610

 ggt gac agc ggt ggt ctc att cct gga aaa tct ctt gtg ttt gca act     8319
 Gly Asp Ser Gly Gly Leu Ile Pro Gly Lys Ser Leu Val Phe Ala Thr
                1615                1620                1625

 atg gag ctg ctg atg ttc att tta gta cgg cat atg cca cat ctc agt     8367
 Met Glu Leu Leu Met Phe Ile Leu Val Arg His Met Pro His Leu Ser
            1630                1635                1640

 acc aag gtg tca gac tct cca agt cac ata gcc act aaa act cga cta     8415
 Thr Lys Val Ser Asp Ser Pro Ser His Ile Ala Thr Lys Thr Arg Leu
        1645                1650                1655

 tca gaa gaa agt gct cgt ttg gtg gca gcc aca gtt acc ata ctc tct     8463
 Ser Glu Glu Ser Ala Arg Leu Val Ala Ala Thr Val Thr Ile Leu Ser
    1660                1665                1670

 gat tta cca tcc ctt tgt tca ccc gct gga tgt atg aca atc ctg ccc     8511
 Asp Leu Pro Ser Leu Cys Ser Pro Ala Gly Cys Met Thr Ile Leu Pro
1675                1680                1685                1690

 aca att ctg ttc tta att gca aga ata ttg aaa gac aca gca ata aag     8559
 Thr Ile Leu Phe Leu Ile Ala Arg Ile Leu Lys Asp Thr Ala Ile Lys
                1695                1700                1705

 tct gca gat aat cag gtt cct cca cca gtc agt gca gct ctt caa ggg     8607
 Ser Ala Asp Asn Gln Val Pro Pro Pro Val Ser Ala Ala Leu Gln Gly
            1710                1715                1720

 att aaa agt att gtg aca ctt tca atg gcc aaa act gag gct ggc gtt     8655
 Ile Lys Ser Ile Val Thr Leu Ser Met Ala Lys Thr Glu Ala Gly Val
        1725                1730                1735

 caa aaa cag tgg aca gct ctg att cgt agc acg ctt gct tgc atc ctg     8703
 Gln Lys Gln Trp Thr Ala Leu Ile Arg Ser Thr Leu Ala Cys Ile Leu
    1740                1745                1750

 gaa tat tct caa cca gaa gac tct gta cct aca cct gat gaa gta agc     8751
 Glu Tyr Ser Gln Pro Glu Asp Ser Val Pro Thr Pro Asp Glu Val Ser
1755                1760                1765                1770

 atg cta aca gca att gca ctc ttc ctg tgg tct gct agt aat gaa ata     8799
 Met Leu Thr Ala Ile Ala Leu Phe Leu Trp Ser Ala Ser Asn Glu Ile
                1775                1780                1785

 ata gga gtc cag tca tta cag aat ggc tgc atg aac aga ttt aaa aat     8847
 Ile Gly Val Gln Ser Leu Gln Asn Gly Cys Met Asn Arg Phe Lys Asn
            1790                1795                1800

 gca tta aat tca tgc gac cca tgg gtt caa gcc aaa tgt tac cag ctt     8895
 Ala Leu Asn Ser Cys Asp Pro Trp Val Gln Ala Lys Cys Tyr Gln Leu
        1805                1810                1815

 ctc ctc tca gtc ttc cag cat tcc aat cgt gcc ctt tca act cct tat     8943
 Leu Leu Ser Val Phe Gln His Ser Asn Arg Ala Leu Ser Thr Pro Tyr
    1820                1825                1830

 att cat tca tta gct cca ata gtg gtt gaa aag cta aaa gct gtt gaa     8991
 Ile His Ser Leu Ala Pro Ile Val Val Glu Lys Leu Lys Ala Val Glu
1835                1840                1845                1850

 aga aac aga cca gcc agt aac ata gag ctt tta gcg gtt caa gaa gga     9039
 Arg Asn Arg Pro Ala Ser Asn Ile Glu Leu Leu Ala Val Gln Glu Gly
                1855                1860                1865

 ata aaa gtt ctt gaa aca ctg gtt gct ctt ggt gaa gaa caa aac aga     9087
 Ile Lys Val Leu Glu Thr Leu Val Ala Leu Gly Glu Glu Gln Asn Arg
            1870                1875                1880

 gtc cag cta ctt gct ctt tta gtt ccc act ttg ata tct tac ctg ctg     9135
 Val Gln Leu Leu Ala Leu Leu Val Pro Thr Leu Ile Ser Tyr Leu Leu
        1885                1890                1895

 gat gaa aat tct ttt gcc tca gca agt tca gct tcc aaa gat ctt cat     9183
 Asp Glu Asn Ser Phe Ala Ser Ala Ser Ser Ala Ser Lys Asp Leu His
    1900                1905                1910

 gag ttt gca ctc cag aat tta atg cat att gga cct ctg tat cca cat     9231
 Glu Phe Ala Leu Gln Asn Leu Met His Ile Gly Pro Leu Tyr Pro His
1915                1920                1925                1930

 gct ttc aag aca gta atg ggg gct gct cct gag ttg aaa gtg cgt cta     9279
 Ala Phe Lys Thr Val Met Gly Ala Ala Pro Glu Leu Lys Val Arg Leu
                1935                1940                1945

 gaa act gcc gtt cga gca agc caa gcg agc aaa gct aaa gcg gct gcc     9327
 Glu Thr Ala Val Arg Ala Ser Gln Ala Ser Lys Ala Lys Ala Ala Ala
            1950                1955                1960

 aga caa cca gcc ccc gcc ata cat tct gca cca aca att aag cta aaa     9375
 Arg Gln Pro Ala Pro Ala Ile His Ser Ala Pro Thr Ile Lys Leu Lys
        1965                1970                1975

 aca agt ttt ttt taa tttgtaattt catttatttg tatttatgtt gtcaactagc     9430
 Thr Ser Phe Phe 
    1980

 ccctaattag tgatggccac tgtatcattc caggctacct atgggttctg ttttatttgt   9490

 atattggtat tatagtgctt ccaagtaggt taagtgaaat aatgctcaca ccatttattg   9550

 atttttaagg agtgattttt tttatcatgt ggtgaatatg ttttcatttt cctcctaata   9610

 atgtttctct tttgttaact tatttatttt tcaaacactg agccatagtc ttaaatttaa   9670

 atgctaaaaa caattgtatc atgtagtcgg gcagcctatt gatactgtca ggggaaaaaa   9730

 atgggtcaga actcagcatc tgtcatgaaa aaaatcaatt gaaaaacaag cagattttaa   9790

 attttgaagt aatcaaaata atggaaagtg tctgttttgt ggtgtatata ctatgaataa   9850

 aatcacagca ttttctaagc                                               9870




      <210> 116
      <211> 2757
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (781)..(2700)

      <400> 116
 aaatctgagc agtcagatcc tcattatttc acatgggaag gtggcaatta ataatatttt     60

 ctcaaacaca tgaccctata ttttgtcagc aagagtcccc agttatgtgt caaggagata    120

 tgacaggccc cactatcatc attcttagac atttagacta attctgctca aagtatcctt    180

 tgtagacttt attgcaggtc tgtgaaagaa taggtaaata aattgaaagt aagggctgag    240

 aaattttggt agcaatttga cattgttata atgtccaatt tttctaatat tttattttta    300

 ttgtatctta cgaaatatcc atatgcaatg gattcgaaat aaagaaaaat ctggtccttc    360

 atcagaacta ggaaagcact gatttaaaca tttggtcaga cattttaaat tgaattagta    420

 agctgtgtgg gctggactac tgctgaagag ctgtattcat gtagtgatga tcaccagata    480

 gtgaagtgga acttgttaac cagtgaaaca actcaaatag taaagcttcc tgatgatatt    540

 taccctattg attttcactg gtttccaaaa agtttgggtg taaagaaaca aacccaggca    600

 gaaagctttg tcctcacaag ttctgatggt aaatttcatc tgatttccaa gttaggaaga    660

 gtggaaaaaa gtgtagaagc tcactgtgga gcagtacttg caggaagatg gaattatgaa    720

 ggaacagcat tagttacagt tggagaagat ggacaaataa aaatttggtc aaagactggg    780
                                                                 
 atg ctt aga tca act tta gct cag caa gga aca cca gtg tat tca gta      828
 Met Leu Arg Ser Thr Leu Ala Gln Gln Gly Thr Pro Val Tyr Ser Val
   1               5                  10                  15

 gcg tgg ggc cct gat tca gaa aag gtt ctt tat aca gca ggc aag cag      876
 Ala Trp Gly Pro Asp Ser Glu Lys Val Leu Tyr Thr Ala Gly Lys Gln
              20                  25                  30

 cta atc att aaa cct ctt caa cca aat gct aaa gtt ttg cag tgg aaa      924
 Leu Ile Ile Lys Pro Leu Gln Pro Asn Ala Lys Val Leu Gln Trp Lys
          35                  40                  45

 gct cat gat ggc att att tta aaa gta gat tgg aac tcg gtc aat gat      972
 Ala His Asp Gly Ile Ile Leu Lys Val Asp Trp Asn Ser Val Asn Asp
      50                  55                  60

 ctt att tta tct gct ggt gaa gac tgt aaa tat aag gta tgg gat agt     1020
 Leu Ile Leu Ser Ala Gly Glu Asp Cys Lys Tyr Lys Val Trp Asp Ser
  65                  70                  75                  80

 tac ggc cgc cca ctg tac aat tca caa cct cat gag cat ccc att act     1068
 Tyr Gly Arg Pro Leu Tyr Asn Ser Gln Pro His Glu His Pro Ile Thr
                  85                  90                  95

 tca gtt gcc tgg gct cca gat gga gaa tta ttt gct gtt gga tcg ttt     1116
 Ser Val Ala Trp Ala Pro Asp Gly Glu Leu Phe Ala Val Gly Ser Phe
             100                 105                 110

 cat act tta cgc ttg tgt gat aaa act ggg tgg tca tat gca tta gaa     1164
 His Thr Leu Arg Leu Cys Asp Lys Thr Gly Trp Ser Tyr Ala Leu Glu
         115                 120                 125

 aaa ccc aac act ggc agc ata ttt aat att gca tgg tct atc gat ggc     1212
 Lys Pro Asn Thr Gly Ser Ile Phe Asn Ile Ala Trp Ser Ile Asp Gly
     130                 135                 140

 act cag att gct gga gcc tgt gga aat gga cat gtc gtt ttt gca cat     1260
 Thr Gln Ile Ala Gly Ala Cys Gly Asn Gly His Val Val Phe Ala His
 145                 150                 155                 160

 gtg gtg gaa caa cat tgg gag tgg aaa aat ttt caa gta aca tta acg     1308
 Val Val Glu Gln His Trp Glu Trp Lys Asn Phe Gln Val Thr Leu Thr
                 165                 170                 175

 aaa aga aga gcc atg cag gtt cgt aat gtt ctt aat gat gca gtg gat     1356
 Lys Arg Arg Ala Met Gln Val Arg Asn Val Leu Asn Asp Ala Val Asp
             180                 185                 190

 tta ctg gaa ttc cgt gat aga gtc att aaa gca tct ttg aac tat gca     1404
 Leu Leu Glu Phe Arg Asp Arg Val Ile Lys Ala Ser Leu Asn Tyr Ala
         195                 200                 205

 cac tta gtt gtt tca acg tct ctt caa tgt tac gtg ttc tcc acg aag     1452
 His Leu Val Val Ser Thr Ser Leu Gln Cys Tyr Val Phe Ser Thr Lys
     210                 215                 220

 aac tgg aac aca cca att ata ttt gat ctc aaa gaa gga act gtt agt     1500
 Asn Trp Asn Thr Pro Ile Ile Phe Asp Leu Lys Glu Gly Thr Val Ser
 225                 230                 235                 240

 ttg att ctg cag gca gaa aga cat ttt ctt ctt gta gat ggt agt agt     1548
 Leu Ile Leu Gln Ala Glu Arg His Phe Leu Leu Val Asp Gly Ser Ser
                 245                 250                 255

 atc tat tta tat tca tat gaa ggg cgc ttt att tca tct cca aaa ttt     1596
 Ile Tyr Leu Tyr Ser Tyr Glu Gly Arg Phe Ile Ser Ser Pro Lys Phe
             260                 265                 270

 cct gga atg aga aca gat att ctg aat gca cag act gtg tct ttg agt     1644
 Pro Gly Met Arg Thr Asp Ile Leu Asn Ala Gln Thr Val Ser Leu Ser
         275                 280                 285

 aat gat acc ata gca ata aga gac aaa gct gat gaa aaa ata atc ttc     1692
 Asn Asp Thr Ile Ala Ile Arg Asp Lys Ala Asp Glu Lys Ile Ile Phe
     290                 295                 300

 ctc ttt gag gca tca acc gga aag ccg tta ggt gat gga aag ttt ctt     1740
 Leu Phe Glu Ala Ser Thr Gly Lys Pro Leu Gly Asp Gly Lys Phe Leu
 305                 310                 315                 320

 tct cat aag aat gaa atc ttg gaa att gct ctg gat caa aaa gga ctt     1788
 Ser His Lys Asn Glu Ile Leu Glu Ile Ala Leu Asp Gln Lys Gly Leu
                 325                 330                 335

 acc aat gat aga aaa att gct ttc att gat aaa aat aga gat ctc tgt     1836
 Thr Asn Asp Arg Lys Ile Ala Phe Ile Asp Lys Asn Arg Asp Leu Cys
             340                 345                 350

 atc act tct gtg aaa cga ttt ggg aag gaa gaa caa att atc aag ctt     1884
 Ile Thr Ser Val Lys Arg Phe Gly Lys Glu Glu Gln Ile Ile Lys Leu
         355                 360                 365

 gga aca atg gtg cat act ttg gca tgg aac gat aca tgc aat atc ctt     1932
 Gly Thr Met Val His Thr Leu Ala Trp Asn Asp Thr Cys Asn Ile Leu
     370                 375                 380

 tgt gga ctt caa gat act cga ttt ata gtg tgg tat tac ccc aat aca     1980
 Cys Gly Leu Gln Asp Thr Arg Phe Ile Val Trp Tyr Tyr Pro Asn Thr
 385                 390                 395                 400

 gtt tat gtg gac aga gac att ttg cct aaa aca tta tat gaa agg gat     2028
 Val Tyr Val Asp Arg Asp Ile Leu Pro Lys Thr Leu Tyr Glu Arg Asp
                 405                 410                 415

 gca agt gaa ttt agt aaa aat ccc cat att gtg agt ttt gtt gga aat     2076
 Ala Ser Glu Phe Ser Lys Asn Pro His Ile Val Ser Phe Val Gly Asn
             420                 425                 430

 caa gta act att aga aga gct gat ggc tcc ctg gtt cac atc agc ata     2124
 Gln Val Thr Ile Arg Arg Ala Asp Gly Ser Leu Val His Ile Ser Ile
         435                 440                 445

 aca cca tat cct gct att ctc cat gaa tat gta agc agt tca aaa tgg     2172
 Thr Pro Tyr Pro Ala Ile Leu His Glu Tyr Val Ser Ser Ser Lys Trp
     450                 455                 460

 gaa gat gct gtg aga ctt tgt cgc ttt gtt aag gag caa acc atg tgg     2220
 Glu Asp Ala Val Arg Leu Cys Arg Phe Val Lys Glu Gln Thr Met Trp
 465                 470                 475                 480

 gct tgt cta gct gct atg gca gtt gct aat cga gat atg act act gca     2268
 Ala Cys Leu Ala Ala Met Ala Val Ala Asn Arg Asp Met Thr Thr Ala
                 485                 490                 495

 gaa ata gcc tat gca gca att ggt gaa att gat aag gtt cag tac atc     2316
 Glu Ile Ala Tyr Ala Ala Ile Gly Glu Ile Asp Lys Val Gln Tyr Ile
             500                 505                 510

 aat tct ata aaa aat ctt cca tct aaa gaa tca aaa atg gcc cac ata     2364
 Asn Ser Ile Lys Asn Leu Pro Ser Lys Glu Ser Lys Met Ala His Ile
         515                 520                 525

 cta ctg ttt agt ggg aac ata cag gag gct gaa ata gta ctt ctt cag     2412
 Leu Leu Phe Ser Gly Asn Ile Gln Glu Ala Glu Ile Val Leu Leu Gln
     530                 535                 540

 gct ggc ctt gtt tat caa gca atc cag atc aat att aat ctc tac aac     2460
 Ala Gly Leu Val Tyr Gln Ala Ile Gln Ile Asn Ile Asn Leu Tyr Asn
 545                 550                 555                 560

 tgg gaa agg gca ctg gaa ttg gct gta aaa tac aaa aca cat gtt gat     2508
 Trp Glu Arg Ala Leu Glu Leu Ala Val Lys Tyr Lys Thr His Val Asp
                 565                 570                 575

 aca gtt ctt gct tac cgt caa aag ttt ttg gag aca ttt ggt aaa cag     2556
 Thr Val Leu Ala Tyr Arg Gln Lys Phe Leu Glu Thr Phe Gly Lys Gln
             580                 585                 590

 gaa act aat aaa cga tac ttg cat tat gca gaa ggt ctc caa ata gat     2604
 Glu Thr Asn Lys Arg Tyr Leu His Tyr Ala Glu Gly Leu Gln Ile Asp
         595                 600                 605

 tgg gag aaa atc aaa gcc aaa att gag atg gaa att aca aaa gaa aga     2652
 Trp Glu Lys Ile Lys Ala Lys Ile Glu Met Glu Ile Thr Lys Glu Arg
     610                 615                 620

 gag caa tca tca agc agc caa tcc agc aag agt ata ggt tta aag ccc     2700
 Glu Gln Ser Ser Ser Ser Gln Ser Ser Lys Ser Ile Gly Leu Lys Pro 
 625                 630                 635                 640

 taaatgccat gcgtatcttt aagaaatttt atcttttgaa acacgttctg attaacc      2757




      <210> 117
      <211> 693
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (58)..(435)

      <400> 117
 ccacgcgtcc gcggacgcgt gggccgaagg ggacgccggg aacaggaatt tcttcac        57                                                                 
 atg gct cct gga gaa gtg acc atc aca gtt cgc ctc atc cgt tcc ttt      105
 Met Ala Pro Gly Glu Val Thr Ile Thr Val Arg Leu Ile Arg Ser Phe
   1               5                  10                  15

 gaa cat cgc aat ttc aaa cct gta gtg tat cac gga gtg aat ttg gac      153
 Glu His Arg Asn Phe Lys Pro Val Val Tyr His Gly Val Asn Leu Asp
              20                  25                  30

 caa act gta aag gaa ttt atc gta ttt cta aag caa gat gtc cct tta      201
 Gln Thr Val Lys Glu Phe Ile Val Phe Leu Lys Gln Asp Val Pro Leu
          35                  40                  45

 agg acc aac ctg cca cca cca ttc aga aat tat aaa tat gat gca cta      249
 Arg Thr Asn Leu Pro Pro Pro Phe Arg Asn Tyr Lys Tyr Asp Ala Leu
      50                  55                  60

 aag att att cat caa gca cat aaa tca aag aca aat gaa ctt gtg ttg      297
 Lys Ile Ile His Gln Ala His Lys Ser Lys Thr Asn Glu Leu Val Leu
  65                  70                  75                  80

 agt ttg gaa gat gac gaa aga ctc ctg ctg aaa gaa gac agc act ctg      345
 Ser Leu Glu Asp Asp Glu Arg Leu Leu Leu Lys Glu Asp Ser Thr Leu
                  85                  90                  95

 aaa gca gct gga atc gcc agt gaa act gaa att gca ttc ttc tgt gaa      393
 Lys Ala Ala Gly Ile Ala Ser Glu Thr Glu Ile Ala Phe Phe Cys Glu
             100                 105                 110

 gaa gat tat agg aac tac aaa gct aat ccc att tca tcc tgg tgaaaac      442
 Glu Asp Tyr Arg Asn Tyr Lys Ala Asn Pro Ile Ser Ser Trp 
         115                 120                 125

 atctcgaggg cttccttttt gcatacctgt attaagctct ttattccact gctgagtttt    502

 tgaaattgac aaacaaatct taaaaaatta atcccaggct atactctttg agctaaaatc    562

 tggttatttc tttctcttca ggtctttctt tccttctctc tttctttttc tttgttgttg    622

 taaaataata tattatgaga aaaacatttg atctttttaa agggaaataa attgttatta    682

 aaaaaaaaaa a                                                         693




      <210> 118
      <211> 2434
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (157)..(1557)

      <400> 118
 tgcccgggcg tcccctgcag acacgcagcc ccgtggaact cccggcggga cggttggggc     60

 tggaggaaca ggacgcccgc tctcggcctc ccttcccggg cctgggctga gggcagccgt    120

 tggtgggttt cagggccgcc tgggcagaat gtcacg  atg gac gag ggc ggc acg     174
                                          Met Asp Glu Gly Gly Thr
                                            1               5

 ccc ctg ctc ccc gac agc ctg gtc tac cag atc ttc ctg agc ctg ggc      222
 Pro Leu Leu Pro Asp Ser Leu Val Tyr Gln Ile Phe Leu Ser Leu Gly
              10                  15                  20

 ccg gcc gac gtg ctg gcc gcc ggg ctg gtg tgc cgc caa tgg cag gcc      270
 Pro Ala Asp Val Leu Ala Ala Gly Leu Val Cys Arg Gln Trp Gln Ala
          25                  30                  35

 gtg tcg cgg gac gag ttc ctg tgg agg gag cag ttc tac cgc tac tac      318
 Val Ser Arg Asp Glu Phe Leu Trp Arg Glu Gln Phe Tyr Arg Tyr Tyr
      40                  45                  50

 cag gtg gcc cgc gac gtg ccc cga cac cca gcg gcc atg tcc tgg tac      366
 Gln Val Ala Arg Asp Val Pro Arg His Pro Ala Ala Met Ser Trp Tyr
  55                  60                  65                  70

 gag gag ttc cag cgg ctg tat gac acg gtg ccc tgc gtg gag gtg cag      414
 Glu Glu Phe Gln Arg Leu Tyr Asp Thr Val Pro Cys Val Glu Val Gln
                  75                  80                  85

 acg ctg cgg gaa cac aca gac cag gtc ctg cac ctc agc ttc tcc cat      462
 Thr Leu Arg Glu His Thr Asp Gln Val Leu His Leu Ser Phe Ser His
              90                  95                 100

 tcc ggg tac cag ttc gcg tcc tgc tcc aag gac tgc act gtg aag atc      510
 Ser Gly Tyr Gln Phe Ala Ser Cys Ser Lys Asp Cys Thr Val Lys Ile
         105                 110                 115

 tgg agc aac gac ctg acc atc tcg ctg ctg cac agc gcg gac atg cgg      558
 Trp Ser Asn Asp Leu Thr Ile Ser Leu Leu His Ser Ala Asp Met Arg
     120                 125                 130

 ccc tac aac tgg agc tac acc cag ttc tcc cag ttc aac aag gac gac      606
 Pro Tyr Asn Trp Ser Tyr Thr Gln Phe Ser Gln Phe Asn Lys Asp Asp
 135                 140                 145                 150

 tcg cta ctg ctg gcc tcg ggg gtg ttc ctg ggg ccg cac aac tcc tca      654
 Ser Leu Leu Leu Ala Ser Gly Val Phe Leu Gly Pro His Asn Ser Ser
                 155                 160                 165

 tcc ggc gag att gct gtc atc agc cta gac tcc ttc gcg ctg ctg tcc      702
 Ser Gly Glu Ile Ala Val Ile Ser Leu Asp Ser Phe Ala Leu Leu Ser
             170                 175                 180

 cgc gtg cgg aac aag ccc tat gac gtg ttt ggc tgt tgg ctc acc gag      750
 Arg Val Arg Asn Lys Pro Tyr Asp Val Phe Gly Cys Trp Leu Thr Glu
         185                 190                 195

 acc agc ctc atc tcg ggg aac ctg cac cgc atc gga gat atc acc tcc      798
 Thr Ser Leu Ile Ser Gly Asn Leu His Arg Ile Gly Asp Ile Thr Ser
     200                 205                 210

 tgc tcg gtg ctg tgg ctc aac aat gcc ttc cag gat gtg gag tca gag      846
 Cys Ser Val Leu Trp Leu Asn Asn Ala Phe Gln Asp Val Glu Ser Glu
 215                 220                 225                 230

 aac gtc aac gtg gtg aag cgg ctg ttc aag atc cag aac ctc aat gcc      894
 Asn Val Asn Val Val Lys Arg Leu Phe Lys Ile Gln Asn Leu Asn Ala
                 235                 240                 245

 agc acc gtc cgc acg gtg atg gtg gcc gac tgc agc cgc ttc gac agc      942
 Ser Thr Val Arg Thr Val Met Val Ala Asp Cys Ser Arg Phe Asp Ser
             250                 255                 260

 cct gac ctg ctg ctg gaa gcc ggt gac ccg gcc acg tcc ccc tgc cgc      990
 Pro Asp Leu Leu Leu Glu Ala Gly Asp Pro Ala Thr Ser Pro Cys Arg
         265                 270                 275

 atc ttt gac ctg ggc agc gac aac gag gag gtg gtg gct ggc ccg gcc     1038
 Ile Phe Asp Leu Gly Ser Asp Asn Glu Glu Val Val Ala Gly Pro Ala
     280                 285                 290

 ccc gcc cac gcc aag gag ggc ttg cgg cac ttt ctg gac cgc gtg ctg     1086
 Pro Ala His Ala Lys Glu Gly Leu Arg His Phe Leu Asp Arg Val Leu
 295                 300                 305                 310

 gag ggg cgg gcg cag cca cag ctg tcg gag cgc atg cta gag acc aag     1134
 Glu Gly Arg Ala Gln Pro Gln Leu Ser Glu Arg Met Leu Glu Thr Lys
                 315                 320                 325

 gtg gcc gag ctg ctg gcc cag ggc cac acc aag cca ccc gag cgc agt     1182
 Val Ala Glu Leu Leu Ala Gln Gly His Thr Lys Pro Pro Glu Arg Ser
             330                 335                 340

 gcc aca ggc gcc aag agc aag tac ctc atc ttc acc act ggc tgc ctc     1230
 Ala Thr Gly Ala Lys Ser Lys Tyr Leu Ile Phe Thr Thr Gly Cys Leu
         345                 350                 355

 acc tac tcc cca cac cag atc ggc atc aag cag atc ctg cca cac cag     1278
 Thr Tyr Ser Pro His Gln Ile Gly Ile Lys Gln Ile Leu Pro His Gln
     360                 365                 370

 atg acc acg gca ggg ccc gtg ctg ggt gag ggc cgg ggc tcc gat gcc     1326
 Met Thr Thr Ala Gly Pro Val Leu Gly Glu Gly Arg Gly Ser Asp Ala
 375                 380                 385                 390

 ttc ttc gac gcg ctg gac cac gtc ata gac ata cac gga cac atc atc     1374
 Phe Phe Asp Ala Leu Asp His Val Ile Asp Ile His Gly His Ile Ile
                 395                 400                 405

 ggc atg ggc ctg tcg ccc gac aac agg tgg gcc tct tgc cag tgt ccc     1422
 Gly Met Gly Leu Ser Pro Asp Asn Arg Trp Ala Ser Cys Gln Cys Pro
             410                 415                 420

 agg cgg ggt gcc cgc agg cgg ccc aca cct agc aca gtg ccc ctc gcc     1470
 Arg Arg Gly Ala Arg Arg Arg Pro Thr Pro Ser Thr Val Pro Leu Ala
         425                 430                 435

 cag gta cct gta cgt gaa cag ccg cgc ctg gcc caa cgg tgc ggt ggt     1518
 Gln Val Pro Val Arg Glu Gln Pro Arg Leu Ala Gln Arg Cys Gly Gly
     440                 445                 450

 ggc cga ccc cat gca gcc gcc acc aat cgc gga gga gat tgacctgctg      1567
 Gly Arg Pro His Ala Ala Ala Thr Asn Arg Gly Gly Asp 
 455                 460                 465

 gtgttcgacc tcaagaccat gcgggaggtg aggcgggctc tgcgtgcgca ccgcgcctac   1627

 acgcccaacg acgagtgctt cttcatcttc ctggacgtca gcagggactt cgtggccagc   1687

 ggggcggagg accggcacgg ctacatctgg gaccgccact acaacatctg tctggccagg   1747

 ctgcggcacg aggatgtggt caactcagtg gtcttcagtc cccaggagca ggagctgctg   1807

 ctcacggcca gcgacgacgc caccatcaaa gcctggcgct ccccacgcac catgcgcgtc   1867

 ctccaggcac ctcgcccacg gcctcgcacc ttcttctcct ggcttgccag ccagaggcgc   1927

 tgaggtgtgc tgggtgcact ggagccaccg ggaccccttg aggacatcgc caggctctgt   1987

 ggctttttcc cgagcgggag aggtggagat gcttatagca gttacgcctt aggaagggga   2047

 caaccaggcc ccgccacacg ctcacacaca aacctgctca cgcagctgtg atgcttggca   2107

 cggggtggcc agtgcagatg gagcccaagg ccccctcggc ctcctgggca acttggggta   2167

 cacaggatac tgggggtgcc gctcctcact caaccccagg ctaggggtac acctgaccca   2227

 gctggcctcg gcccggggca ccttcggctg gtcctgtggg gccctggacg gtggcccagt   2287

 ggtggcaggg gctgctcctg gctgtggttg tgcgcccggg gcttgggagc ggccggtcac   2347

 gctgctgtgg gcccgagtgt gttgcatgtc cacgcaccac ccgttcaggg ccctgaataa   2407

 acagttggca acagcaaaaa aaaaaaa                                       2434




      <210> 119
      <211> 4389
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (223)..(2388)

      <400> 119
 attctttgga atactactgc tagaagtctg acttaagacc cagcttatgg gccacatggc     60

 acccagctgc ttctgcagag aaggcaggcc actgatgggt acagcaaagt gtggtgctgc    120

 tggccaagcc aaagacccgt gtaggatgac tgggcctctg ccccttgtgg gtgttgccac    180

 tgtgcttgag tgcctggtga agaatgtgat gggatcacta gc   atg tct gcg gag     234
                                                  Met Ser Ala Glu
                                                    1

 agc ggc cct ggg acg aga ttg aga aat ctg cca gta atg ggg gat gga      282
 Ser Gly Pro Gly Thr Arg Leu Arg Asn Leu Pro Val Met Gly Asp Gly
   5                  10                  15                  20

 cta gaa act tcc caa atg tct aca aca cag gcc cag gcc caa ccc cag      330
 Leu Glu Thr Ser Gln Met Ser Thr Thr Gln Ala Gln Ala Gln Pro Gln
                  25                  30                  35

 cca gcc aac gca gcc agc acc aac ccc ccg ccc cca gag acc tcc aac      378
 Pro Ala Asn Ala Ala Ser Thr Asn Pro Pro Pro Pro Glu Thr Ser Asn
              40                  45                  50

 cct aac aag ccc aag agg cag acc aac caa ctg caa tac ctg ctc aga      426
 Pro Asn Lys Pro Lys Arg Gln Thr Asn Gln Leu Gln Tyr Leu Leu Arg
          55                  60                  65

 gtg gtg ctc aag aca cta tgg aaa cac cag ttt gca tgg cct ttc cag      474
 Val Val Leu Lys Thr Leu Trp Lys His Gln Phe Ala Trp Pro Phe Gln
      70                  75                  80

 cag cct gtg gat gcc gtc aag ctg aac ctc cct gat tac tat aag atc      522
 Gln Pro Val Asp Ala Val Lys Leu Asn Leu Pro Asp Tyr Tyr Lys Ile
  85                  90                  95                 100

 att aaa acg cct atg gat atg gga aca ata aag aag cgc ttg gaa aac      570
 Ile Lys Thr Pro Met Asp Met Gly Thr Ile Lys Lys Arg Leu Glu Asn
                 105                 110                 115

 aac tat tac tgg aat gct cag gaa tgt atc cag gac ttc aac act atg      618
 Asn Tyr Tyr Trp Asn Ala Gln Glu Cys Ile Gln Asp Phe Asn Thr Met
             120                 125                 130

 ttt aca aat tgt tac atc tac aac aag cct gga gat gac ata gtc tta      666
 Phe Thr Asn Cys Tyr Ile Tyr Asn Lys Pro Gly Asp Asp Ile Val Leu
         135                 140                 145

 atg gca gaa gct ctg gaa aag ctc ttc ttg caa aaa ata aat gag cta      714
 Met Ala Glu Ala Leu Glu Lys Leu Phe Leu Gln Lys Ile Asn Glu Leu
     150                 155                 160

 ccc aca gaa gaa acc gag atc atg ata gtc cag gca aaa gga aga gga      762
 Pro Thr Glu Glu Thr Glu Ile Met Ile Val Gln Ala Lys Gly Arg Gly
 165                 170                 175                 180

 cgt ggg agg aaa gaa aca ggg aca gca aaa cct ggc gtt tcc acg gta      810
 Arg Gly Arg Lys Glu Thr Gly Thr Ala Lys Pro Gly Val Ser Thr Val
                 185                 190                 195

 cca aac aca act caa gca tcg act cct ccg cag acc cag acc cct cag      858
 Pro Asn Thr Thr Gln Ala Ser Thr Pro Pro Gln Thr Gln Thr Pro Gln
             200                 205                 210

 ccg aat cct cct cct gtg cag gcc acg cct cac ccc ttc cct gcc gtc      906
 Pro Asn Pro Pro Pro Val Gln Ala Thr Pro His Pro Phe Pro Ala Val
         215                 220                 225

 acc ccg gac ctc atc gtc cag acc cct gtc atg aca gtg gtg cct ccc      954
 Thr Pro Asp Leu Ile Val Gln Thr Pro Val Met Thr Val Val Pro Pro
     230                 235                 240

 cag cca ctg cag acg ccc ccg cca gtg ccc ccc cag cca caa ccc cca     1002
 Gln Pro Leu Gln Thr Pro Pro Pro Val Pro Pro Gln Pro Gln Pro Pro
 245                 250                 255                 260

 ccc gct cca gct ccc cag ccc gta cag agc cac cca ccc atc atc gcg     1050
 Pro Ala Pro Ala Pro Gln Pro Val Gln Ser His Pro Pro Ile Ile Ala
                 265                 270                 275

 gcc acc cca cag cct gtg aag aca aag aag gga gtg aag agg aaa gca     1098
 Ala Thr Pro Gln Pro Val Lys Thr Lys Lys Gly Val Lys Arg Lys Ala
             280                 285                 290

 gac acc acc acc ccc acc acc att gac ccc att cac gag cca ccc tcg     1146
 Asp Thr Thr Thr Pro Thr Thr Ile Asp Pro Ile His Glu Pro Pro Ser
         295                 300                 305

 ctg ccc ccg gag ccc aag acc acc aag ctg ggc cag cgg cgg gag agc     1194
 Leu Pro Pro Glu Pro Lys Thr Thr Lys Leu Gly Gln Arg Arg Glu Ser
     310                 315                 320

 agc cgg cct gtg aaa cct cca aag aag gac gtg ccc gac tct cag cag     1242
 Ser Arg Pro Val Lys Pro Pro Lys Lys Asp Val Pro Asp Ser Gln Gln
 325                 330                 335                 340

 cac cca gca cca gag aag agc agc aag gtc tcg gag cag ctc aag tgc     1290
 His Pro Ala Pro Glu Lys Ser Ser Lys Val Ser Glu Gln Leu Lys Cys
                 345                 350                 355

 tgc agc ggc atc ctc aag gag atg ttt gcc aag aag cac gcc gcc tac     1338
 Cys Ser Gly Ile Leu Lys Glu Met Phe Ala Lys Lys His Ala Ala Tyr
             360                 365                 370

 gcc tgg ccc ttc tac aag cct gtg gac gtg gag gca ctg ggc cta cac     1386
 Ala Trp Pro Phe Tyr Lys Pro Val Asp Val Glu Ala Leu Gly Leu His
         375                 380                 385

 gac tac tgt gac atc atc aag cac ccc atg gac atg agc aca atc aag     1434
 Asp Tyr Cys Asp Ile Ile Lys His Pro Met Asp Met Ser Thr Ile Lys
     390                 395                 400

 tct aaa ctg gag gcc cgt gag tac cgt gat gct cag gag ttt ggt gct     1482
 Ser Lys Leu Glu Ala Arg Glu Tyr Arg Asp Ala Gln Glu Phe Gly Ala
 405                 410                 415                 420

 gac gtc cga ttg atg ttc tcc aac tgc tat aag tac aac cct cct gac     1530
 Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr Asn Pro Pro Asp
                 425                 430                 435

 cat gag gtg gtg gcc atg gcc cgc aag ctc cag gat gtg ttc gaa atg     1578
 His Glu Val Val Ala Met Ala Arg Lys Leu Gln Asp Val Phe Glu Met
             440                 445                 450

 cgc ttt gcc aag atg ccg gac gag cct gag gag cca gtg gtg gcc gtg     1626
 Arg Phe Ala Lys Met Pro Asp Glu Pro Glu Glu Pro Val Val Ala Val
         455                 460                 465

 tcc tcc ccg gca gtg ccc cct ccc acc aag gtt gtg gcc ccg ccc tca     1674
 Ser Ser Pro Ala Val Pro Pro Pro Thr Lys Val Val Ala Pro Pro Ser
     470                 475                 480

 tcc agc gac agc agc agc gat agc tcc tcg gac agt gac agt tcg act     1722
 Ser Ser Asp Ser Ser Ser Asp Ser Ser Ser Asp Ser Asp Ser Ser Thr
 485                 490                 495                 500

 gat gac tct gag gag gag cga gcc cag cgg ctg gct gag ctc cag gag     1770
 Asp Asp Ser Glu Glu Glu Arg Ala Gln Arg Leu Ala Glu Leu Gln Glu
                 505                 510                 515

 cag ctc aaa gcc gtg cac gag cag ctt gca gcc ctc tct cag ccc cag     1818
 Gln Leu Lys Ala Val His Glu Gln Leu Ala Ala Leu Ser Gln Pro Gln
             520                 525                 530

 cag aac aaa cca aag aaa aag gag aaa gac aag aag gaa aag aaa aaa     1866
 Gln Asn Lys Pro Lys Lys Lys Glu Lys Asp Lys Lys Glu Lys Lys Lys
         535                 540                 545

 gaa aag cac aaa agg aaa gag gaa gtg gaa gag aat aaa aaa agc aaa     1914
 Glu Lys His Lys Arg Lys Glu Glu Val Glu Glu Asn Lys Lys Ser Lys
     550                 555                 560

 gcc aag gaa cct cct cct aaa aag acg aag aaa aat aat agc agc aac     1962
 Ala Lys Glu Pro Pro Pro Lys Lys Thr Lys Lys Asn Asn Ser Ser Asn
 565                 570                 575                 580

 agc aat gtg agc aag aag gag cca gcg ccc atg aag agc aag ccc cct     2010
 Ser Asn Val Ser Lys Lys Glu Pro Ala Pro Met Lys Ser Lys Pro Pro
                 585                 590                 595

 ccc acg tat gag tcg gag gaa gag gac aag tgc aag cct atg tcc tat     2058
 Pro Thr Tyr Glu Ser Glu Glu Glu Asp Lys Cys Lys Pro Met Ser Tyr
             600                 605                 610

 gag gag aag cgg cag ctc agc ttg gac atc aac aag ctc ccc ggc gag     2106
 Glu Glu Lys Arg Gln Leu Ser Leu Asp Ile Asn Lys Leu Pro Gly Glu
         615                 620                 625

 aag ctg ggc cgc gtg gtg cac atc atc cag tca cgg gag ccc tcc ctg     2154
 Lys Leu Gly Arg Val Val His Ile Ile Gln Ser Arg Glu Pro Ser Leu
     630                 635                 640

 aag aat tcc aac ccc gac gag att gaa atc gac ttt gag acc ctg aag     2202
 Lys Asn Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe Glu Thr Leu Lys
 645                 650                 655                 660

 ccg tcc aca ctg cgt gag ctg gag cgc tat gtc acc tcc tgt ttg cgg     2250
 Pro Ser Thr Leu Arg Glu Leu Glu Arg Tyr Val Thr Ser Cys Leu Arg
                 665                 670                 675

 aag aaa agg aaa cct caa gct gag aaa gtt gat gtg att gcc ggc tcc     2298
 Lys Lys Arg Lys Pro Gln Ala Glu Lys Val Asp Val Ile Ala Gly Ser
             680                 685                 690

 tcc aag atg aag ggc ttc tcg tcc tca gag tcg gag agc tcc agt gag     2346
 Ser Lys Met Lys Gly Phe Ser Ser Ser Glu Ser Glu Ser Ser Ser Glu
         695                 700                 705

 tcc agc tcc tct gac agc gaa gac tcc gaa aca ggt cct gcc taatcat     2395
 Ser Ser Ser Ser Asp Ser Glu Asp Ser Glu Thr Gly Pro Ala 
     710                 715                 720

 tggacacgga ctcttaataa aacggtcttc agttccagat tccttcccag caagctatag   2455

 cttaagtcca ttttcttccg tgaaagggac aggactccat caagttatgg aattcctcag   2515

 agccctgggc ctgtcccccg gggtggatta gtcatgtcca gcagcacacg cctagtcccg   2575

 ccttcgggaa ggctgcctgc ctggccagcc gcccaggcct ctctgtgtaa agactgcctg   2635

 gctgtcctgc ccagccttcc tggttctctg gggtcctctg ggtgggtggc atctcctgga   2695

 gggtgatgac aatccccaac acatgcattc atgtggtgct actctgtgtg caaagccaga   2755

 ccccaagtat gttttctctc tttgtcccat ccctcttttt ctgggacttt ggaccctaac   2815

 tacttccctc ctgaaccttg cagtgacatc agtccaggag agctctcgtt cagtgtgcgg   2875

 aagaacactc tgacctctag agctgtccta gataaggagt gggagcttta gaggcaaggc   2935

 ctctagaccc tggaaggctc agtgaggctc ttcccacagc atgcttctca ctggtgccct   2995

 gtaaggctcg agccaccgct gactctgagc cttttggagt ctttcctcct tcgtctccat   3055

 tgttcccgtg catttccaaa agcttaagtt gcctggtggg catttcccca gtttctttgg   3115

 cctccgtctt ctcaagtcac atagggaaag tacctcctgg aaccaggctg cagtatgcag   3175

 gacctgccag gcaggcactg gtgaagggcc ttgggcctat catcccctca accccacctc   3235

 accccacccg cctcctctag tggggtgagt ctgggctggt ggaccagaga gggtgtcaca   3295

 gaccctcagg gactgcccca tggacacctc tgactggtgt taacagtgtg aacattttcc   3355

 ccgtcttcag tcccttagaa tgacgacagc ccctggggtt ggggcaggcg agtgtggcca   3415

 catcatccaa gccctcccag agacacaaat aggctttttt gctctaaaaa taaataccag   3475

 cccttttttg gtcacaaatc cagcatctca gcagaaaact gcctgacatg aaaagtcccc   3535

 tgaggaactg catctgcgtt tcaggggctt ttcatttttt ctcctttttt aaagtgtaga   3595

 ttgtgggtgc ttcctagagg cctgccttct tctggaactg gaagtgggct atcaccatgg   3655

 gcaagccctt gggtgcaggc tccccacctg cctgggaact ctggcagctc tcctcagctc   3715

 cttgggcttg agcagctgca actgccccag atttgctgtg gaagcagggg ctagccctgg   3775

 cctcaccagg gcctcccggg gccctgcatt gatgctcagg agttcctggg ctgctcttga   3835

 tcctttctgg gcatccagct tccagttaag ctctgtttgc caaacaaact attctcagct   3895

 gccctttggc ctgcgcctga tgtgttcctg ttgcagtccc gcctgcctga gacaggagca   3955

 ggcaggagag ccttcatgcc cagattccca caggacaatt ggggagctgc tggcattgtc   4015

 tttctgggaa gattctgctt tcttggacca aatggcagcc tgattaccag tgtcgggcct   4075

 gcatgctgcc cccgacacac gcacgcacgc gcacacacgt gtgcacatgg gccatagcca   4135

 caagccagct ctcctccagg gtcctttcaa cctcgctgtc cagggaccct gtccttcttg   4195

 cccgtggggc ttccatctgg cagagaacgt tcagggcttg ttgaacttga aagctcatta   4255

 gacttaagct gtcacctgtg cttggtgccc caggaacagc cagagaggac agtgcccact   4315

 cacttcttgt tggcagcctc ctgtgcagga agtgccagcc gggcctcgac gcaccagctg   4375

 gctgtgggtc ctga                                                     4389




      <210> 120
      <211> 1796
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (55)..(1743)

      <400> 120
 cgagagccgc gtccacgttc ctgcctcctg ctcccgccgc cctggggcgc cgcc  atg      57
                                                              Met
                                                                1

 acg ccc gat ctg ctc aac ttc aag aag gga tgg atg tcg atc ttg gac      105
 Thr Pro Asp Leu Leu Asn Phe Lys Lys Gly Trp Met Ser Ile Leu Asp
               5                  10                  15

 gag cct gga gag cct ccc tcc ccc tcg ctc acc acc acc tct act tcg      153
 Glu Pro Gly Glu Pro Pro Ser Pro Ser Leu Thr Thr Thr Ser Thr Ser
          20                  25                  30

 cag tgg aag aaa cat tgg ttt gtg ctg aca gat tca agt ctc aaa tat      201
 Gln Trp Lys Lys His Trp Phe Val Leu Thr Asp Ser Ser Leu Lys Tyr
      35                  40                  45

 tac aga gac tcc act gct gag gag gca gat gag ctg gat ggt gag atc      249
 Tyr Arg Asp Ser Thr Ala Glu Glu Ala Asp Glu Leu Asp Gly Glu Ile
  50                  55                  60                  65

 gac ctg cgt tcc tgc acg gat gtc act gag tac gcg gtg cag cgc aac      297
 Asp Leu Arg Ser Cys Thr Asp Val Thr Glu Tyr Ala Val Gln Arg Asn
                  70                  75                  80

 tat ggc ttc cag atc cac acc aag gat gct gtc tat acc ttg tcg gcc      345
 Tyr Gly Phe Gln Ile His Thr Lys Asp Ala Val Tyr Thr Leu Ser Ala
              85                  90                  95

 atg acc tca ggc atc cgg cgg aac tgg atc gag gct ctg aga aag acc      393
 Met Thr Ser Gly Ile Arg Arg Asn Trp Ile Glu Ala Leu Arg Lys Thr
         100                 105                 110

 gta cgt cca act tca gcc cca gat gtc acc aag ctc tcg gac tct aac      441
 Val Arg Pro Thr Ser Ala Pro Asp Val Thr Lys Leu Ser Asp Ser Asn
     115                 120                 125

 aag gag aac gcg ctg cac agc tac agc acc cag aag ggc ccc ctg aag      489
 Lys Glu Asn Ala Leu His Ser Tyr Ser Thr Gln Lys Gly Pro Leu Lys
 130                 135                 140                 145

 gca ggg gag cag cgg gcg ggc tct gag gtc atc agc cgg ggt ggc cct      537
 Ala Gly Glu Gln Arg Ala Gly Ser Glu Val Ile Ser Arg Gly Gly Pro
                 150                 155                 160

 cgg aag gcg gac ggg cag cgt cag gcc ttg gac tac gtg gag ctc tcg      585
 Arg Lys Ala Asp Gly Gln Arg Gln Ala Leu Asp Tyr Val Glu Leu Ser
             165                 170                 175

 ccg ctg acc cag gct tcc ccg cag cgg gcc cgc acc cca gcc cgc act      633
 Pro Leu Thr Gln Ala Ser Pro Gln Arg Ala Arg Thr Pro Ala Arg Thr
         180                 185                 190

 cct gac cgc ctg gcc aag cag gag gag ctg gag cgg gac ctg gcc cag      681
 Pro Asp Arg Leu Ala Lys Gln Glu Glu Leu Glu Arg Asp Leu Ala Gln
     195                 200                 205

 cgc tcc gag gag cgg cgc aag tgg ttt gag gcc aca gac agc agg acc      729
 Arg Ser Glu Glu Arg Arg Lys Trp Phe Glu Ala Thr Asp Ser Arg Thr
 210                 215                 220                 225

 cca gag gtg cct gct ggt gag ggg ccg cgc cgg ggc ctg ggt gcc ccc      777
 Pro Glu Val Pro Ala Gly Glu Gly Pro Arg Arg Gly Leu Gly Ala Pro
                 230                 235                 240

 ctg act gag gac cag caa aac cgg ctt agt gag gag atc gag aag aag      825
 Leu Thr Glu Asp Gln Gln Asn Arg Leu Ser Glu Glu Ile Glu Lys Lys
             245                 250                 255

 tgg cag gag ctg gag aag ctg ccc ctg cgg gag aat aag cgg gtg ccc      873
 Trp Gln Glu Leu Glu Lys Leu Pro Leu Arg Glu Asn Lys Arg Val Pro
         260                 265                 270

 ctc act gcc ctg ctc aac caa agc cgc gga gag cgc cga ggg ccc cca      921
 Leu Thr Ala Leu Leu Asn Gln Ser Arg Gly Glu Arg Arg Gly Pro Pro
     275                 280                 285

 agt gac ggc cac gag gca ctg gag aag gag gtt cag gct ctt cgg gcc      969
 Ser Asp Gly His Glu Ala Leu Glu Lys Glu Val Gln Ala Leu Arg Ala
 290                 295                 300                 305

 cag ctg gag gcg tgg cgt ctc caa ggg gag gct cct cag agt gca ctg     1017
 Gln Leu Glu Ala Trp Arg Leu Gln Gly Glu Ala Pro Gln Ser Ala Leu
                 310                 315                 320

 aga tcc cag gag gat ggc cac atc ccc ccg ggc tac atc tca cag gag     1065
 Arg Ser Gln Glu Asp Gly His Ile Pro Pro Gly Tyr Ile Ser Gln Glu
             325                 330                 335

 gca tgt gag cgc agc ctg gca gag atg gag tcc tcg cac cag cag gtg     1113
 Ala Cys Glu Arg Ser Leu Ala Glu Met Glu Ser Ser His Gln Gln Val
         340                 345                 350

 atg gag gag ctg cag cgg cac cac gag cgg gag ctg cag cgc ctg cag     1161
 Met Glu Glu Leu Gln Arg His His Glu Arg Glu Leu Gln Arg Leu Gln
     355                 360                 365

 cag gag aag gag tgg ctc ctg gct gag gag acg gca gcc acg gcc tca     1209
 Gln Glu Lys Glu Trp Leu Leu Ala Glu Glu Thr Ala Ala Thr Ala Ser
 370                 375                 380                 385

 gcc att gaa gcc atg aag aag gcc tac cag gaa gag ctg agc cga gag     1257
 Ala Ile Glu Ala Met Lys Lys Ala Tyr Gln Glu Glu Leu Ser Arg Glu
                 390                 395                 400

 ctg agc aaa aca cgg agt ctc cag cag ggc ccg gat ggc ctc cgg aag     1305
 Leu Ser Lys Thr Arg Ser Leu Gln Gln Gly Pro Asp Gly Leu Arg Lys
             405                 410                 415

 cag cac cag tca gat gtg gag gca ctg aag cga gag ctg cag gtg cta     1353
 Gln His Gln Ser Asp Val Glu Ala Leu Lys Arg Glu Leu Gln Val Leu
         420                 425                 430

 tcg gag cag tac tcg cag aag tgc ctg gag att ggg gca ctc atg cgg     1401
 Ser Glu Gln Tyr Ser Gln Lys Cys Leu Glu Ile Gly Ala Leu Met Arg
     435                 440                 445

 cag gct gag gag cgc gag cac acg ctg cgc cgc tgc cag cag gag ggc     1449
 Gln Ala Glu Glu Arg Glu His Thr Leu Arg Arg Cys Gln Gln Glu Gly
 450                 455                 460                 465

 cag gag ctg ctg cgc cac aac cag gag ctg cat ggg ccg cct gtc aga     1497
 Gln Glu Leu Leu Arg His Asn Gln Glu Leu His Gly Pro Pro Val Arg
                 470                 475                 480

 gga gat aga cca gct gcg cgg ctt cat tgc ctc gca ggg cat ggg caa     1545
 Gly Asp Arg Pro Ala Ala Arg Leu His Cys Leu Ala Gly His Gly Gln
             485                 490                 495

 tgg ctg cgg gcg cag caa cga gcg gag ttc ctg cga gct aga ggt gct     1593
 Trp Leu Arg Ala Gln Gln Arg Ala Glu Phe Leu Arg Ala Arg Gly Ala
         500                 505                 510

 gct tcg cgt aaa aga aaa cga act cca gta cct aaa gaa gga ggt gca     1641
 Ala Ser Arg Lys Arg Lys Arg Thr Pro Val Pro Lys Glu Gly Gly Ala
     515                 520                 525

 gtg cct ccg gga cga gct cca gat gat gca gaa gga caa gcg ctt cac     1689
 Val Pro Pro Gly Arg Ala Pro Asp Asp Ala Glu Gly Gln Ala Leu His
 530                 535                 540                 545

 ctc ggg aaa gta cca gga cgt cta tgt gga gct gag cca cat caa gac     1737
 Leu Gly Lys Val Pro Gly Arg Leu Cys Gly Ala Glu Pro His Gln Asp
                 550                 555                 560

 acg gtc tgagcgggag atcgagcagc tgaaggagca cctgcgtctt gccatggccg      1793
 Thr Val 


 ccc                                                                 1796




      <210> 121
      <211> 1683
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (967)..(1368)

      <400> 121
 gttctggaaa tagagtggtt tgttttattt tgagacagtg gcacctaggc tggagtgcac     60

 tgaagcgtca acctcctagg cccaagtgat ccttccacct cagcctcctg agtagctggg    120

 actacaggca cctgctacca cgcctgacta atttttgtat ttttagtaca gatggggttt    180

 cgccacgttg gccaggctgg tctcgaactc ctgacctcag gtgatctgcc cgtctcgtcc    240

 tcccaaagtg ctgggattac aggtgtgagc caccacgccc agccaccact acgcacttta    300

 aaaccaaaaa aagctcaaag ggatggatca ttgtccatgg ctcaggagcc ccactgtggg    360

 ctaagtgtga tgtcgatgga ttaatttaga cagtggtgta ttcatcaggg caaaggaaat    420

 tcttccagag gtgatgatgc ggcagactac ttcccagtcg tctctcccaa acgcatagca    480

 tggcccgtcg ttgtcgactc ctcgtcgagt tgggctggca accagctttg ccactcgctt    540

 tcctacgaat gctactcaac gcctcgttct gtaaactact cgaagcgaat tcgactgggc    600

 gttcgagcga aacggatggc tgcatgtgac cagggtccca aggccacagc ttttcagatc    660

 ctaggaagca agtggcattt gcttgagttg tggcctcgga aggagaatgt ttatctgttt    720

 tctaactttg ctgacaccag gattctccct gtcattgaga agaaagcatt atctaattac    780

 cttcaggtgg tttacttatt ctgtaaagaa tatgtgtaaa tattttgtac agagccctgt    840

 atcaaataaa cagccatatg tggttactaa tcacctcttc tgtcattccg tccttggcca    900

 ccgctcagtg ggaatggtct ctgatctgga tgctcccacc ttccatgtca ggcccagaac    960

 tgtgcc   atg gtc tgt gga ctc ctg gtc agc ctt gac tgg cta gga gac    1008
          Met Val Cys Gly Leu Leu Val Ser Leu Asp Trp Leu Gly Asp
            1               5                  10

 ctt ggg cag tac cta cag tct tgc tgt ttc tgt ttc atc tgc aag aat     1056
 Leu Gly Gln Tyr Leu Gln Ser Cys Cys Phe Cys Phe Ile Cys Lys Asn
  15                  20                  25                  30

 tat gac cca cac act cca gct gca gcc cag ggc act gtg ata ttt tat     1104
 Tyr Asp Pro His Thr Pro Ala Ala Ala Gln Gly Thr Val Ile Phe Tyr
                  35                  40                  45

 acg tgt gta gat gtt ttt gtc cac agt tcc tgg ttc atc act ccc ata     1152
 Thr Cys Val Asp Val Phe Val His Ser Ser Trp Phe Ile Thr Pro Ile
              50                  55                  60

 acc ctt tgt tat aat gtt ggg aca ctg cag gcc tca gaa aac gga atc     1200
 Thr Leu Cys Tyr Asn Val Gly Thr Leu Gln Ala Ser Glu Asn Gly Ile
          65                  70                  75

 tct gtc tgt gac ctt ctc ctg ccc cat ttc act tgc tca aca cca gac     1248
 Ser Val Cys Asp Leu Leu Leu Pro His Phe Thr Cys Ser Thr Pro Asp
      80                  85                  90

 ttt aat ctg act gta gct cat aag acc ctc att cca gag agg gtg ctg     1296
 Phe Asn Leu Thr Val Ala His Lys Thr Leu Ile Pro Glu Arg Val Leu
  95                 100                 105                 110

 ccc cat acc cgg aag gag gaa cgc tgc aca gag agg cca aga agc atc     1344
 Pro His Thr Arg Lys Glu Glu Arg Cys Thr Glu Arg Pro Arg Ser Ile
                 115                 120                 125

 tgg aca gac agg cct tgc tgg gtt tagaccttat gctttttgtc cagtttcatc    1398
 Trp Thr Asp Arg Pro Cys Trp Val 
             130

 tcaacacagc tgccatgctt cagccatgcc tatccaatga cgtctccata aaaggcccag   1458

 gaacacggga gcttctgaag agctgaacat gtggagggag gggaacgaga acttgtccat   1518

 gtgccaagag ggtggcgcac ccccactcca tggggacaga agctccagca tttgcccagg   1578

 acccgtccag acctcaccct gtgtgtatct tcatctggct gtttacttat ttgtatcctt   1638

 ttctaataac gtttgtaata aactggtaaa cataaaaaaa aaaaa                   1683




      <210> 122
      <211> 9212
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2915)..(9037)

      <400> 122
 atggcacaac tagaagagtc tacaatgtta cccagcacgc tgctggcatt gttgtatacc     60

 aacaagggcc tgattcttgc caagagaatt aatgtgcgta tcgagcacat taagctcact    120

 aagagccgag atagcttcct gaaacacatg aaggaaaatg accagaaaaa gaaaacaaag    180

 agaaaggcgg cgggaccagt gcagccgccg cctcccagga tcgtccgccg gtcagggccc    240

 ttgccctccc cggcacaggc caccatggcc accaacccac agccgcagcc gcctcctccg    300

 gcgccgccgc ctcccccgcc gcagccgcag ccgcagccac cgccgccgcc gccgggcccc    360

 ggggctggcc ccggcgcggg cggggcgggc ggcgcgggtg cgggcgccgg ggacccgcag    420

 ctcgtggcca tgatcgtgaa ccacctcaag agccaggggc tcttcgacca gttccgcaga    480

 gactgcctgg ccgacgtgga caccaagcct gcgtatcaga atctgagaca gcgtgttgac    540

 aactttgttg caaatcactt ggcaactcac acatggagtc cgcatctcaa taagaaccag    600

 ctaagaaaca acattagaca acaagtcctc aaatcaggaa tgttggagtc tggtattgac    660

 cgaattattt ctcaggttgt ggacccaaag atcaaccaca cattcagacc tcaggtagag    720

 aaagctgtgc atgagttttt ggccacgcta aatcacaaag aggaaggaag tggcaacaca    780

 gctcccgatg atgagaaacc agacacttcc cttattacac aaggtgttcc tactcctggg    840

 cccagtgcta atgtagccaa tgatgccatg tcgatattgg aaaccataac ttctcttaac    900

 caagaagcca gtgctgctag ggcttcaaca gaaacatcaa atgccaagac cagtgagaga    960

 gcgtcaaaaa aacttccatc tcagccaacc actgatacta gtactgacaa agaaagaact   1020

 tcagaggaca tggctgataa agaaaaatct acagctgact ctggaggtga aggactggaa   1080

 acagccccaa agtctgaaga gttcagcgac ctcccctgtc cagtcgaaga aattaaaaat   1140

 tacacaaaag agcataataa tttaattctg ctaaataagg atgttcaaca ggaaagcagt   1200

 gagcaaaaaa ataaatcaac agacaaaggt gaaaagaagc cagacagcaa tgagaaagga   1260

 gaaagaaaga aagaaaagaa ggaaaagact gaaaagaaat ttgatcactc aaaaaagagt   1320

 gaagatacac agaaagttaa agatgaaaaa caagcaaagg aaaaagaagt agagagttta   1380

 aaacttcctt cagaaaagaa cagtaataaa gctaaaactg ttgaagggac aaaagaagat   1440

 ttctctttga tagattctga tgtggatgga cttacagaca tcacagttag ctctgttcat   1500

 accagtgacc tttcatcttt tgaagaagat actgaggagg aagttgtaac gtctgatagc   1560

 atggaagaag gagagattac gtcagatgat gaagagaaga acaaacagaa taaaacaaaa   1620

 actcaaacta gtgattctag tgaaggaaaa acaaaaagtg tacggcatgc gtatgtccac   1680

 aaaccatatc tttactcaaa atactatagt gattctgatg atgagcttac tgtagaacaa   1740

 cgacgacagt ccattggtat tttgtggttt taggccaaag aaaaagaaga gaggctttta   1800

 agaaggcaaa tcaatagaga aaaacttgaa gaaaaacgaa aacagaaagc agaaaagaca   1860

 aagtcttcaa aaaccaaggg tcaaggcagg agtagtgtgg acttagaaga atcatcaaca   1920

 aagagtttgg aacctaaagc cgccagaatt aaagaagtcc ttaaagaacg gaaagtttta   1980

 gaaaaaaaag tagccttaag caaaaagaga aaaaaagatt caaggaatgt tgaagagaac   2040

 tccaaaaaga aacagcaata tgaagaagat tccaaagaaa cccttaaaac aagtgagcat   2100

 tgtgaaaagg aaaaaatttc ttcttcaaag gagctgaagc atgttcatgc aaaaagtgaa   2160

 ccaagtaaac ctgcccggag actttcagag tctttgcatg tagttgacga aaacaaaaat   2220

 gaatccaaaa tagaaagaga acataaaaga cggacatcta cccctgttat catggagggg   2280

 gtacaggaag agactgacac aagagatgta aaaaggcaag tagaacgctc agaaatttgc   2340

 accgaagagc cccagaaaca gaaaagcaca cttaaaaacg aaaagcatct aaagaaagat   2400

 gattctgaaa caccacattt gaaaagccta cttaagaaag aggtgaaatc ctccaaggag   2460

 aagcctgaaa gagagaaaac tccatcggaa gacaaattgt ctgtgaaaca taaatataaa   2520

 ggtgattgta tgcataaaac aggtgatgag actgagcttc actcttctga gaaaggttta   2580

 aaagtagagg aaaatattca aaagcaaagt caacaaacaa agctttcttc agatgataaa   2640

 accgaacgaa aaagtaaaca taggaatgaa aggaaattat cagtattagg caaagatgga   2700

 aagccagttt ctgaatatat tataaaaaca gatgagaatg ttcgtaaaaa aaaaaaaaaa   2760

 aaatgagaga cgcttgtcag ctgaaaaaac taaggcagag cacaaatcaa gaaggtcaag   2820

 tgattctaaa attcagaaag attctctggg ttccaagcaa catggtatca cattacagag   2880

 aagaagtgaa agttattcgg aagataagtg tgat    atg gac tcc act aac atg    2932
                                          Met Asp Ser Thr Asn Met
                                            1               5

 gat agt aat ttg aaa cca gaa gag gtt gtt cac aag gag aaa cga cga     2980
 Asp Ser Asn Leu Lys Pro Glu Glu Val Val His Lys Glu Lys Arg Arg
              10                  15                  20

 aca aag agc ttg tta gaa gag aaa ctt gtg ttg aag tct aaa tca aaa     3028
 Thr Lys Ser Leu Leu Glu Glu Lys Leu Val Leu Lys Ser Lys Ser Lys
          25                  30                  35

 act caa ggc aaa cag gta aaa gtt gta gaa aca gaa tta caa gaa ggt     3076
 Thr Gln Gly Lys Gln Val Lys Val Val Glu Thr Glu Leu Gln Glu Gly
      40                  45                  50

 gcc aca aaa cag gca acc act cca aaa cca gac aag gag aag aac aca     3124
 Ala Thr Lys Gln Ala Thr Thr Pro Lys Pro Asp Lys Glu Lys Asn Thr
  55                  60                  65                  70

 gaa gaa aat gac tca gaa aaa cag cgt aag tct aaa gtt gaa gac aaa     3172
 Glu Glu Asn Asp Ser Glu Lys Gln Arg Lys Ser Lys Val Glu Asp Lys
                  75                  80                  85

 cct ttt gaa gaa act ggt gtt gaa cct gta tta gag act gct tct tct     3220
 Pro Phe Glu Glu Thr Gly Val Glu Pro Val Leu Glu Thr Ala Ser Ser
              90                  95                 100

 tca gca cat agt aca cag aag gat tct agt cat aga gcc aag tta cca     3268
 Ser Ala His Ser Thr Gln Lys Asp Ser Ser His Arg Ala Lys Leu Pro
         105                 110                 115

 tta gca aag gag aaa tat aag agt gat aaa gac tcc act tcc acc agg     3316
 Leu Ala Lys Glu Lys Tyr Lys Ser Asp Lys Asp Ser Thr Ser Thr Arg
     120                 125                 130

 ctt gag aga aag ttg tca gat ggc cac aaa agc aga agc tta aag cat     3364
 Leu Glu Arg Lys Leu Ser Asp Gly His Lys Ser Arg Ser Leu Lys His
 135                 140                 145                 150

 agt agt aaa aac ata aaa aaa aag gac gaa aat aaa tca gat gac aag     3412
 Ser Ser Lys Asn Ile Lys Lys Lys Asp Glu Asn Lys Ser Asp Asp Lys
                 155                 160                 165

 gat ggt aaa gaa gtt gac agt agt cat gaa aag gcc aga ggt aat agt     3460
 Asp Gly Lys Glu Val Asp Ser Ser His Glu Lys Ala Arg Gly Asn Ser
             170                 175                 180

 tca ctc atg gaa aag aaa tta agt aga agg ttg tgc gaa aat cgg aga     3508
 Ser Leu Met Glu Lys Lys Leu Ser Arg Arg Leu Cys Glu Asn Arg Arg
         185                 190                 195

 gga agc ttg tca caa gaa atg gcc aaa gga gaa gaa aaa tta gca gca     3556
 Gly Ser Leu Ser Gln Glu Met Ala Lys Gly Glu Glu Lys Leu Ala Ala
     200                 205                 210

 aac act ttg agc act ccc agc ggt tcc tcc ctt cag aga cca aaa aag     3604
 Asn Thr Leu Ser Thr Pro Ser Gly Ser Ser Leu Gln Arg Pro Lys Lys
 215                 220                 225                 230

 agt ggt gat atg aca ttg atc cct gaa caa gag cca atg gaa att gat     3652
 Ser Gly Asp Met Thr Leu Ile Pro Glu Gln Glu Pro Met Glu Ile Asp
                 235                 240                 245

 tct gag cca ggt gtt gaa aat gtg ttt gaa gta tct aaa acc caa gac     3700
 Ser Glu Pro Gly Val Glu Asn Val Phe Glu Val Ser Lys Thr Gln Asp
             250                 255                 260

 aac cgc aat aat aat tct cag caa gac att gac tct gaa aat atg aaa     3748
 Asn Arg Asn Asn Asn Ser Gln Gln Asp Ile Asp Ser Glu Asn Met Lys
         265                 270                 275

 caa aaa act tct gcc act gtt caa aag gat gaa ttg aga act tgc aca     3796
 Gln Lys Thr Ser Ala Thr Val Gln Lys Asp Glu Leu Arg Thr Cys Thr
     280                 285                 290

 gca gat tca aaa gca aca gct cca gct tat aag cca ggc cgt gga aca     3844
 Ala Asp Ser Lys Ala Thr Ala Pro Ala Tyr Lys Pro Gly Arg Gly Thr
 295                 300                 305                 310

 gga gtt aat agt aat tct gaa aag cat gcc gat cat aga agc acc ttg     3892
 Gly Val Asn Ser Asn Ser Glu Lys His Ala Asp His Arg Ser Thr Leu
                 315                 320                 325

 acc aag aaa atg cat ata caa agt gct gtg tcc aaa atg aac cct ggg     3940
 Thr Lys Lys Met His Ile Gln Ser Ala Val Ser Lys Met Asn Pro Gly
             330                 335                 340

 gag aaa gaa ccc att cat aga gga act act gaa gtg aat ata gat tct     3988
 Glu Lys Glu Pro Ile His Arg Gly Thr Thr Glu Val Asn Ile Asp Ser
         345                 350                 355

 gaa act gtt cat aga atg tta ctg agt gcc cca tca gaa aat gat agg     4036
 Glu Thr Val His Arg Met Leu Leu Ser Ala Pro Ser Glu Asn Asp Arg
     360                 365                 370

 gta cag aag aat ttg aaa aac aca gct gct gaa gaa cat gtt gct caa     4084
 Val Gln Lys Asn Leu Lys Asn Thr Ala Ala Glu Glu His Val Ala Gln
 375                 380                 385                 390

 gga gat gcc act ctt gaa cat tcc aca aat tta gac tcc tca cca tcc     4132
 Gly Asp Ala Thr Leu Glu His Ser Thr Asn Leu Asp Ser Ser Pro Ser
                 395                 400                 405

 tta agt tca gtg act gtt gtg cct ctg agg gaa tcg tat gat cca gat     4180
 Leu Ser Ser Val Thr Val Val Pro Leu Arg Glu Ser Tyr Asp Pro Asp
             410                 415                 420

 gta att cct ctg ttt gac aaa aga act gtt ttg gaa ggt agc aca gcc     4228
 Val Ile Pro Leu Phe Asp Lys Arg Thr Val Leu Glu Gly Ser Thr Ala
         425                 430                 435

 agc acc tcc cct gcg gat cac tct gct ctc cct aac caa agt ctg act     4276
 Ser Thr Ser Pro Ala Asp His Ser Ala Leu Pro Asn Gln Ser Leu Thr
     440                 445                 450

 gtt agg gaa tca gaa gtc ctt aag aca agt gac agc aaa gaa ggt ggt     4324
 Val Arg Glu Ser Glu Val Leu Lys Thr Ser Asp Ser Lys Glu Gly Gly
 455                 460                 465                 470

 gaa ggt ttc aca gta gat aca cca gca aaa gca agc atc act agc aaa     4372
 Glu Gly Phe Thr Val Asp Thr Pro Ala Lys Ala Ser Ile Thr Ser Lys
                 475                 480                 485

 aga cac att cca gaa gct cac cag gct act tta ttg gat ggt aaa caa     4420
 Arg His Ile Pro Glu Ala His Gln Ala Thr Leu Leu Asp Gly Lys Gln
             490                 495                 500

 gga aag gta atc atg cct ctt gga agt aag tta acg ggc gtg att gtg     4468
 Gly Lys Val Ile Met Pro Leu Gly Ser Lys Leu Thr Gly Val Ile Val
         505                 510                 515

 gaa aat gag aat att acc aaa gaa ggt ggc tta gtg gac atg gcc aag     4516
 Glu Asn Glu Asn Ile Thr Lys Glu Gly Gly Leu Val Asp Met Ala Lys
     520                 525                 530

 aaa gaa aat gac tta aat gca gag ccc aat tta aag cag aca att aaa     4564
 Lys Glu Asn Asp Leu Asn Ala Glu Pro Asn Leu Lys Gln Thr Ile Lys
 535                 540                 545                 550

 gca aca gta gag aat ggc aag aag gat ggc att gct gtt gat cat gtt     4612
 Ala Thr Val Glu Asn Gly Lys Lys Asp Gly Ile Ala Val Asp His Val
                 555                 560                 565

 gta ggc ctg aat aca gaa aaa tat gct gaa act gtc aaa ctt aag cat     4660
 Val Gly Leu Asn Thr Glu Lys Tyr Ala Glu Thr Val Lys Leu Lys His
             570                 575                 580

 aaa aga agc cca ggt aaa gta aaa gac ata tca att gat gtt gaa aga     4708
 Lys Arg Ser Pro Gly Lys Val Lys Asp Ile Ser Ile Asp Val Glu Arg
         585                 590                 595

 agg aat gaa aac agt gag gta gac acc agt gct gga agt ggc tct gca     4756
 Arg Asn Glu Asn Ser Glu Val Asp Thr Ser Ala Gly Ser Gly Ser Ala
     600                 605                 610

 ccc tct gtt tta cac caa agg aac gga caa act gag gat gtg gca act     4804
 Pro Ser Val Leu His Gln Arg Asn Gly Gln Thr Glu Asp Val Ala Thr
 615                 620                 625                 630

 ggg cct agg aga gca gaa aag act tct gtt gcc act agt act gaa ggg     4852
 Gly Pro Arg Arg Ala Glu Lys Thr Ser Val Ala Thr Ser Thr Glu Gly
                 635                 640                 645

 aag gac aaa gat gtc acc tta agt cca gtg aag gct ggg cct gcc aca     4900
 Lys Asp Lys Asp Val Thr Leu Ser Pro Val Lys Ala Gly Pro Ala Thr
             650                 655                 660

 acc act tct tca gaa aca aga caa agt gag gtg gct ttg cct tgc acc     4948
 Thr Thr Ser Ser Glu Thr Arg Gln Ser Glu Val Ala Leu Pro Cys Thr
         665                 670                 675

 agc att gag gca gat gaa ggc ctc ata ata gga aca cat tcc aga aat     4996
 Ser Ile Glu Ala Asp Glu Gly Leu Ile Ile Gly Thr His Ser Arg Asn
     680                 685                 690

 aat cct ctt cat gtt ggt gca gaa gcc agt gaa tgc act gtt ttt gct     5044
 Asn Pro Leu His Val Gly Ala Glu Ala Ser Glu Cys Thr Val Phe Ala
 695                 700                 705                 710

 gca gct gaa gaa ggt ggg gct gtt gtc aca gag gga ttt gct gaa agt     5092
 Ala Ala Glu Glu Gly Gly Ala Val Val Thr Glu Gly Phe Ala Glu Ser
                 715                 720                 725

 gaa acc ttc ctc aca agc act aag gaa ggg gaa agt ggg gag tgt gct     5140
 Glu Thr Phe Leu Thr Ser Thr Lys Glu Gly Glu Ser Gly Glu Cys Ala
             730                 735                 740

 gtg gct gaa tct gag gac aga gca gca gac cta ctg gct gtg cat gca     5188
 Val Ala Glu Ser Glu Asp Arg Ala Ala Asp Leu Leu Ala Val His Ala
         745                 750                 755

 gtt aaa atc gaa gcc aat gta aat agc gtt gtg aca gag gaa aag gat     5236
 Val Lys Ile Glu Ala Asn Val Asn Ser Val Val Thr Glu Glu Lys Asp
     760                 765                 770

 gat gct gta acc agt gca ggc tct gaa gaa aaa tgt gat ggt tct tta     5284
 Asp Ala Val Thr Ser Ala Gly Ser Glu Glu Lys Cys Asp Gly Ser Leu
 775                 780                 785                 790

 agt aga gac tca gaa ata gtt gaa gga act att act ttt att agt gaa     5332
 Ser Arg Asp Ser Glu Ile Val Glu Gly Thr Ile Thr Phe Ile Ser Glu
                 795                 800                 805

 gtt gaa agt gat gga gca gtt aca agt gct gga aca gag ata aga gca     5380
 Val Glu Ser Asp Gly Ala Val Thr Ser Ala Gly Thr Glu Ile Arg Ala
             810                 815                 820

 gga tct ata agc agt gaa gag gtg gat ggc tcc cag gga aat atg atg     5428
 Gly Ser Ile Ser Ser Glu Glu Val Asp Gly Ser Gln Gly Asn Met Met
         825                 830                 835

 aga atg ggt ccc aaa aaa gaa aca gag ggc act gtg aca tgt aca gga     5476
 Arg Met Gly Pro Lys Lys Glu Thr Glu Gly Thr Val Thr Cys Thr Gly
     840                 845                 850

 gca gaa ggc aga agt gat aac ttt gtg atc tgc tca gta act gga gca     5524
 Ala Glu Gly Arg Ser Asp Asn Phe Val Ile Cys Ser Val Thr Gly Ala
 855                 860                 865                 870

 ggg ccc cgg gag gaa cgc atg gtt aca ggt gca ggt gtt gtc ctg gga     5572
 Gly Pro Arg Glu Glu Arg Met Val Thr Gly Ala Gly Val Val Leu Gly
                 875                 880                 885

 gat aat gat gca cca cca gga aca agt gcc agc caa gaa gga gat ggt     5620
 Asp Asn Asp Ala Pro Pro Gly Thr Ser Ala Ser Gln Glu Gly Asp Gly
             890                 895                 900

 tct gtg aat gat ggt aca gaa ggt gag agt gca gtc acc agc acg ggg     5668
 Ser Val Asn Asp Gly Thr Glu Gly Glu Ser Ala Val Thr Ser Thr Gly
         905                 910                 915

 ata aca gaa gat gga gag ggg cca gca agt tgc aca ggt tca gaa gat     5716
 Ile Thr Glu Asp Gly Glu Gly Pro Ala Ser Cys Thr Gly Ser Glu Asp
     920                 925                 930

 agc agc gaa ggc ttt gct ata agt tct gaa tcg gaa gaa aat gga gag     5764
 Ser Ser Glu Gly Phe Ala Ile Ser Ser Glu Ser Glu Glu Asn Gly Glu
 935                 940                 945                 950

 agt gca atg gac agc aca gtg gcc aaa gaa ggc act aat gta cca tta     5812
 Ser Ala Met Asp Ser Thr Val Ala Lys Glu Gly Thr Asn Val Pro Leu
                 955                 960                 965

 gtt gct gct ggt cct tgt gat gat gaa ggc att gtg act agc aca ggc     5860
 Val Ala Ala Gly Pro Cys Asp Asp Glu Gly Ile Val Thr Ser Thr Gly
             970                 975                 980

 gca aaa gag gaa gac gag gaa ggg gag gat gtt gtg act agt act gga     5908
 Ala Lys Glu Glu Asp Glu Glu Gly Glu Asp Val Val Thr Ser Thr Gly
         985                 990                 995

 aga gga aat gaa att ggg cat gct tca act tgt aca ggg tta gga gaa     5956
 Arg Gly Asn Glu Ile Gly His Ala Ser Thr Cys Thr Gly Leu Gly Glu
    1000                1005                1010

 gaa agt gaa ggg gtc ttg att tgt gaa agt gca gaa ggg gac agt cag     6004
 Glu Ser Glu Gly Val Leu Ile Cys Glu Ser Ala Glu Gly Asp Ser Gln
1015                1020                1025                1030

 att ggt act gtg gta gag cat gtg gaa gct gag gct gga gct gcc atc     6052
 Ile Gly Thr Val Val Glu His Val Glu Ala Glu Ala Gly Ala Ala Ile
                1035                1040                1045

 atg aat gca aat gaa aat aat gtt gac agc atg agt ggc aca gag aaa     6100
 Met Asn Ala Asn Glu Asn Asn Val Asp Ser Met Ser Gly Thr Glu Lys
            1050                1055                1060

 gga agt aaa gac aca gat atc tgc tcc agt gca aaa ggg att gta gaa     6148
 Gly Ser Lys Asp Thr Asp Ile Cys Ser Ser Ala Lys Gly Ile Val Glu
        1065                1070                1075

 agc agt gtg acc agt gca gtc tca gga aag gat gaa gtg aca cca gtt     6196
 Ser Ser Val Thr Ser Ala Val Ser Gly Lys Asp Glu Val Thr Pro Val
    1080                1085                1090

 cca gga ggt tgt gag ggt cct atg act agt gct gca tct gat caa agt     6244
 Pro Gly Gly Cys Glu Gly Pro Met Thr Ser Ala Ala Ser Asp Gln Ser
1095                1100                1105                1110

 gac agt cag ctc gaa aaa gtt gaa gat acc act att tcc act ggc ctg     6292
 Asp Ser Gln Leu Glu Lys Val Glu Asp Thr Thr Ile Ser Thr Gly Leu
                1115                1120                1125

 gtc ggg ggt agt tac gat gtt ctt gta tct ggt gaa gtc cca gaa tgt     6340
 Val Gly Gly Ser Tyr Asp Val Leu Val Ser Gly Glu Val Pro Glu Cys
            1130                1135                1140

 gaa gtt gct cac aca tca cca agt gaa aaa gaa gat gag gac atc atc     6388
 Glu Val Ala His Thr Ser Pro Ser Glu Lys Glu Asp Glu Asp Ile Ile
        1145                1150                1155

 acc tct gta gaa aat gaa gag tgt gat ggt ctc atg gca act aca gcc     6436
 Thr Ser Val Glu Asn Glu Glu Cys Asp Gly Leu Met Ala Thr Thr Ala
    1160                1165                1170

 agt ggt gat att acc aac cag aat agc tta gca ggg ggt aaa aat caa     6484
 Ser Gly Asp Ile Thr Asn Gln Asn Ser Leu Ala Gly Gly Lys Asn Gln
1175                1180                1185                1190

 ggc aaa gtt ttg att att tcc acc agt acc aca aat gat tac acc cct     6532
 Gly Lys Val Leu Ile Ile Ser Thr Ser Thr Thr Asn Asp Tyr Thr Pro
                1195                1200                1205

 cag gta agc gca att aca gat gtg gaa gga ggt ctc tca gat gct ctg     6580
 Gln Val Ser Ala Ile Thr Asp Val Glu Gly Gly Leu Ser Asp Ala Leu
            1210                1215                1220

 aga act gaa gaa aat atg gaa ggt acc aga gta acc aca gaa gaa ttt     6628
 Arg Thr Glu Glu Asn Met Glu Gly Thr Arg Val Thr Thr Glu Glu Phe
        1225                1230                1235

 gag gcc ccc atg ccc agt gca gtc tca gga gat gac agc caa ctc act     6676
 Glu Ala Pro Met Pro Ser Ala Val Ser Gly Asp Asp Ser Gln Leu Thr
    1240                1245                1250

 gcc agc aga agt gaa gag aaa gat gag tgt gcc atg att tcc aca agc     6724
 Ala Ser Arg Ser Glu Glu Lys Asp Glu Cys Ala Met Ile Ser Thr Ser
1255                1260                1265                1270

 ata ggg gaa gaa ttc gaa ttg cct atc tcc agt gca aca acc atc aag     6772
 Ile Gly Glu Glu Phe Glu Leu Pro Ile Ser Ser Ala Thr Thr Ile Lys
                1275                1280                1285

 tgt gct gaa agt ctt cag ccg gtt gct gca gca gtg gaa gaa agg gct     6820
 Cys Ala Glu Ser Leu Gln Pro Val Ala Ala Ala Val Glu Glu Arg Ala
            1290                1295                1300

 aca ggt cca gtc ttg ata agc acc gcc gac ttt gag ggg cct atg ccc     6868
 Thr Gly Pro Val Leu Ile Ser Thr Ala Asp Phe Glu Gly Pro Met Pro
        1305                1310                1315

 agt gcg ccc cca gaa gct gaa agt cct ctt gcc tca acc agc aag gag     6916
 Ser Ala Pro Pro Glu Ala Glu Ser Pro Leu Ala Ser Thr Ser Lys Glu
    1320                1325                1330

 gag aag gat gaa tgt gct ctc att tcc act agc ata gca gaa gaa tgt     6964
 Glu Lys Asp Glu Cys Ala Leu Ile Ser Thr Ser Ile Ala Glu Glu Cys
1335                1340                1345                1350

 gag gct tct gtt tcc ggt gta gtt gtt gaa agt gaa aat gag cga gct     7012
 Glu Ala Ser Val Ser Gly Val Val Val Glu Ser Glu Asn Glu Arg Ala
                1355                1360                1365

 ggc aca gtc atg gaa gaa aaa gac ggg agt ggc atc atc tct acg agc     7060
 Gly Thr Val Met Glu Glu Lys Asp Gly Ser Gly Ile Ile Ser Thr Ser
            1370                1375                1380

 tcg gtg gaa gac tgt gag ggc cca gtg tcc agt gct gtc cct caa gag     7108
 Ser Val Glu Asp Cys Glu Gly Pro Val Ser Ser Ala Val Pro Gln Glu
        1385                1390                1395

 gaa ggc gac ccc tca gtc aca cca gcg gaa gag atg ggt gac acc gcc     7156
 Glu Gly Asp Pro Ser Val Thr Pro Ala Glu Glu Met Gly Asp Thr Ala
    1400                1405                1410

 atg att tcc aca agc acc tct gaa ggg tgt gaa gca gtc atg att ggt     7204
 Met Ile Ser Thr Ser Thr Ser Glu Gly Cys Glu Ala Val Met Ile Gly
1415                1420                1425                1430

 gct gtc ctc cag gat gaa gat cgg ctc acc atc aca aga gta gaa gac     7252
 Ala Val Leu Gln Asp Glu Asp Arg Leu Thr Ile Thr Arg Val Glu Asp
                1435                1440                1445

 ttg agc gat gct gcc atc atc tcc acc agc aca gca gaa tgt atg cca     7300
 Leu Ser Asp Ala Ala Ile Ile Ser Thr Ser Thr Ala Glu Cys Met Pro
            1450                1455                1460

 att tcc gcc agc att gac aga cat gaa gag aat cag ctg act gca gac     7348
 Ile Ser Ala Ser Ile Asp Arg His Glu Glu Asn Gln Leu Thr Ala Asp
        1465                1470                1475

 aac cca gaa ggg aac ggt gac ctg tca gcc aca gaa gtg agc aag cac     7396
 Asn Pro Glu Gly Asn Gly Asp Leu Ser Ala Thr Glu Val Ser Lys His
    1480                1485                1490

 aag gtc ccc atg ccc agc cta att gct gag aat aac tgt cgg tgt cct     7444
 Lys Val Pro Met Pro Ser Leu Ile Ala Glu Asn Asn Cys Arg Cys Pro
1495                1500                1505                1510

 ggg cca gtc agg gga ggc aaa gaa ccg ggt ccc gtg ttg gca gtg agc     7492
 Gly Pro Val Arg Gly Gly Lys Glu Pro Gly Pro Val Leu Ala Val Ser
                1515                1520                1525

 acc gag gag ggg cac aac ggg cca tca gtc cac aag ccc tct gca ggg     7540
 Thr Glu Glu Gly His Asn Gly Pro Ser Val His Lys Pro Ser Ala Gly
            1530                1535                1540

 caa ggc cat cca agt gct gtt tgt gcg gaa aaa gaa gag aag cat ggc     7588
 Gln Gly His Pro Ser Ala Val Cys Ala Glu Lys Glu Glu Lys His Gly
        1545                1550                1555

 aag gag tgc ccc gaa ata gga cca ttt gca gga aga gga cag aaa gag     7636
 Lys Glu Cys Pro Glu Ile Gly Pro Phe Ala Gly Arg Gly Gln Lys Glu
    1560                1565                1570

 agc act tta cac ctc ata aat gca gaa gag aag aat gta ttg ttg aac     7684
 Ser Thr Leu His Leu Ile Asn Ala Glu Glu Lys Asn Val Leu Leu Asn
1575                1580                1585                1590

 tcc ctt cag aaa gaa gat aag agc cca gag aca ggg aca gca ggg ggc     7732
 Ser Leu Gln Lys Glu Asp Lys Ser Pro Glu Thr Gly Thr Ala Gly Gly
                1595                1600                1605

 agt agc aca gca agt tat tca gca gga agg ggc tta gag ggg aat gct     7780
 Ser Ser Thr Ala Ser Tyr Ser Ala Gly Arg Gly Leu Glu Gly Asn Ala
            1610                1615                1620

 aac tca cct gcc cac ctg aga gga cca gaa cag acg tct ggg cag acg     7828
 Asn Ser Pro Ala His Leu Arg Gly Pro Glu Gln Thr Ser Gly Gln Thr
        1625                1630                1635

 gct aag gat tcc tct gtc agc agc att cgc tat ttg gca gca gta aac     7876
 Ala Lys Asp Ser Ser Val Ser Ser Ile Arg Tyr Leu Ala Ala Val Asn
    1640                1645                1650

 acc ggt gct ata aaa gct gat gac atg cca cct gtt caa ggg acc gtg     7924
 Thr Gly Ala Ile Lys Ala Asp Asp Met Pro Pro Val Gln Gly Thr Val
1655                1660                1665                1670

 gct gag cat tcc ttt ctt cct gct gag cag cag ggg tct gaa gac aac     7972
 Ala Glu His Ser Phe Leu Pro Ala Glu Gln Gln Gly Ser Glu Asp Asn
                1675                1680                1685

 ttg aaa acc agt acc acc aaa tgt att act ggc caa gaa tca aaa att     8020
 Leu Lys Thr Ser Thr Thr Lys Cys Ile Thr Gly Gln Glu Ser Lys Ile
            1690                1695                1700

 gct cct tcc cac aca atg atc cct cca gct act tac agt gta gct ctg     8068
 Ala Pro Ser His Thr Met Ile Pro Pro Ala Thr Tyr Ser Val Ala Leu
        1705                1710                1715

 ttg gct cct aaa tgt gag cag gac ttg act ata aag aat gat tat agt     8116
 Leu Ala Pro Lys Cys Glu Gln Asp Leu Thr Ile Lys Asn Asp Tyr Ser
    1720                1725                1730

 ggc aaa tgg act gat caa gca tct gct gag aaa aca gga gat gat aac     8164
 Gly Lys Trp Thr Asp Gln Ala Ser Ala Glu Lys Thr Gly Asp Asp Asn
1735                1740                1745                1750

 agc aca agg aaa tca ttc cct gag gaa gga gac ata atg gtt act gtg     8212
 Ser Thr Arg Lys Ser Phe Pro Glu Glu Gly Asp Ile Met Val Thr Val
                1755                1760                1765

 tct tct gaa gaa aat gct tat gtg cct tca gag gaa gag aaa aat ggt     8260
 Ser Ser Glu Glu Asn Ala Tyr Val Pro Ser Glu Glu Glu Lys Asn Gly
            1770                1775                1780

 gaa att ctg gca cca cca gaa agt ctg tgt ggg gga aag cca agt gga     8308
 Glu Ile Leu Ala Pro Pro Glu Ser Leu Cys Gly Gly Lys Pro Ser Gly
        1785                1790                1795

 ata gag ata tcc agt ggt aga aaa gac aac gca gaa gcc ata agc ggt     8356
 Ile Glu Ile Ser Ser Gly Arg Lys Asp Asn Ala Glu Ala Ile Ser Gly
    1800                1805                1810

 cac agt gtt gaa gca gat cct aaa gag gaa gag aac tcc aga gat ttg     8404
 His Ser Val Glu Ala Asp Pro Lys Glu Glu Glu Asn Ser Arg Asp Leu
1815                1820                1825                1830

 gaa gaa tta cct aaa acc agt tct gag aca aat agc act acc tca agg     8452
 Glu Glu Leu Pro Lys Thr Ser Ser Glu Thr Asn Ser Thr Thr Ser Arg
                1835                1840                1845

 gtc atg gaa gaa aaa gat gaa tat agc agc agt gaa act act ggt gaa     8500
 Val Met Glu Glu Lys Asp Glu Tyr Ser Ser Ser Glu Thr Thr Gly Glu
            1850                1855                1860

 aag cca gag cag aac gat gat gac acc ata aaa tct cag gag gat gat     8548
 Lys Pro Glu Gln Asn Asp Asp Asp Thr Ile Lys Ser Gln Glu Asp Asp
        1865                1870                1875

 ggt gaa gaa aaa ata gta aca agt gtg cgt cgg aga gga aga aaa ccc     8596
 Gly Glu Glu Lys Ile Val Thr Ser Val Arg Arg Arg Gly Arg Lys Pro
    1880                1885                1890

 aaa cgt tct ctc act gta tca gat gat gct gaa tcc tca gag cca gaa     8644
 Lys Arg Ser Leu Thr Val Ser Asp Asp Ala Glu Ser Ser Glu Pro Glu
1895                1900                1905                1910

 aga aaa cgc cag aaa tca gtt tct gat cca gtg gag gac aag aaa gag     8692
 Arg Lys Arg Gln Lys Ser Val Ser Asp Pro Val Glu Asp Lys Lys Glu
                1915                1920                1925

 cag gag tct gat gag gaa gag gaa gaa gag gaa gag gac gag cct tca     8740
 Gln Glu Ser Asp Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Pro Ser
            1930                1935                1940

 gga gcc acc aca aga tcc acc acc aga tca gag gct cag aga aag caa     8788
 Gly Ala Thr Thr Arg Ser Thr Thr Arg Ser Glu Ala Gln Arg Lys Gln
        1945                1950                1955

 cat agc aag cca tct gca cgt gca aca tcc aaa ctt ggc agc cca gac     8836
 His Ser Lys Pro Ser Ala Arg Ala Thr Ser Lys Leu Gly Ser Pro Asp
    1960                1965                1970

 aca gtt tct cct aga aat cgc caa aaa tta gca aaa gag aag tta cct     8884
 Thr Val Ser Pro Arg Asn Arg Gln Lys Leu Ala Lys Glu Lys Leu Pro
1975                1980                1985                1990

 acc agc gaa aaa gtt agt aac tct ccc cca tta gga aga tca aag aca     8932
 Thr Ser Glu Lys Val Ser Asn Ser Pro Pro Leu Gly Arg Ser Lys Thr
                1995                2000                2005

 cag ctc tcc cct tct atc aag cgc aag aga gaa gtc agc cct cct ggg     8980
 Gln Leu Ser Pro Ser Ile Lys Arg Lys Arg Glu Val Ser Pro Pro Gly
            2010                2015                2020

 gcc cga aca aga ggc cag caa agg gtg gag gaa gcc cct gtg aaa aaa     9028
 Ala Arg Thr Arg Gly Gln Gln Arg Val Glu Glu Ala Pro Val Lys Lys
        2025                2030                2035

 gcg aag cga taatcct gaccactgct gccctaggct tatggaggaa cacggtggag     9084
 Ala Lys Arg 
    2040

 aggaaagaga catgccttgg tggccatagg cttctcttta accaggaaaa agatatgcat   9144

 gtgctgtaag tccctagggt gcaagctttt tcttgttatg ttttaaacag ctttataaac   9204

 tattgttg                                                            9212




      <210> 123
      <211> 9071
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2915)..(8896)

      <400> 123
 atggcacaac tagaagagtc tacaatgtta cccagcacgc tgctggcatt gttgtatacc     60

 aacaagggcc tgattcttgc caagagaatt aatgtgcgta tcgagcacat taagctcact    120

 aagagccgag atagcttcct gaaacacatg aaggaaaatg accagaaaaa gaaaacaaag    180

 agaaaggcgg cgggaccagt gcagccgccg cctcccagga tcgtccgccg gtcagggccc    240

 ttgccctccc cggcacaggc caccatggcc accaacccac agccgcagcc gcctcctccg    300

 gcgccgccgc ctcccccgcc gcagccgcag ccgcagccac cgccgccgcc gccgggcccc    360

 ggggctggcc ccggcgcggg cggggcgggc ggcgcgggtg cgggcgccgg ggacccgcag    420

 ctcgtggcca tgatcgtgaa ccacctcaag agccaggggc tcttcgacca gttccgcaga    480

 gactgcctgg ccgacgtgga caccaagcct gcgtatcaga atctgagaca gcgtgttgac    540

 aactttgttg caaatcactt ggcaactcac acatggagtc cgcatctcaa taagaaccag    600

 ctaagaaaca acattagaca acaagtcctc aaatcaggaa tgttggagtc tggtattgac    660

 cgaattattt ctcaggttgt ggacccaaag atcaaccaca cattcagacc tcaggtagag    720

 aaagctgtgc atgagttttt ggccacgcta aatcacaaag aggaaggaag tggcaacaca    780

 gctcccgatg atgagaaacc agacacttcc cttattacac aaggtgttcc tactcctggg    840

 cccagtgcta atgtagccaa tgatgccatg tcgatattgg aaaccataac ttctcttaac    900

 caagaagcca gtgctgctag ggcttcaaca gaaacatcaa atgccaagac cagtgagaga    960

 gcgtcaaaaa aacttccatc tcagccaacc actgatacta gtactgacaa agaaagaact   1020

 tcagaggaca tggctgataa agaaaaatct acagctgact ctggaggtga aggactggaa   1080

 acagccccaa agtctgaaga gttcagcgac ctcccctgtc cagtcgaaga aattaaaaat   1140

 tacacaaaag agcataataa tttaattctg ctaaataagg atgttcaaca ggaaagcagt   1200

 gagcaaaaaa ataaatcaac agacaaaggt gaaaagaagc cagacagcaa tgagaaagga   1260

 gaaagaaaga aagaaaagaa ggaaaagact gaaaagaaat ttgatcactc aaaaaagagt   1320

 gaagatacac agaaagttaa agatgaaaaa caagcaaagg aaaaagaagt agagagttta   1380

 aaacttcctt cagaaaagaa cagtaataaa gctaaaactg ttgaagggac aaaagaagat   1440

 ttctctttga tagattctga tgtggatgga cttacagaca tcacagttag ctctgttcat   1500

 accagtgacc tttcatcttt tgaagaagat actgaggagg aagttgtaac gtctgatagc   1560

 atggaagaag gagagattac gtcagatgat gaagagaaga acaaacagaa taaaacaaaa   1620

 actcaaacta gtgattctag tgaaggaaaa acaaaaagtg tacggcatgc gtatgtccac   1680

 aaaccatatc tttactcaaa atactatagt gattctgatg atgagcttac tgtagaacaa   1740

 cgacgacagt ccattggtat tttgtggttt taggccaaag aaaaagaaga gaggctttta   1800

 agaaggcaaa tcaatagaga aaaacttgaa gaaaaacgaa aacagaaagc agaaaagaca   1860

 aagtcttcaa aaaccaaggg tcaaggcagg agtagtgtgg acttagaaga atcatcaaca   1920

 aagagtttgg aacctaaagc cgccagaatt aaagaagtcc ttaaagaacg gaaagtttta   1980

 gaaaaaaaag tagccttaag caaaaagaga aaaaaagatt caaggaatgt tgaagagaac   2040

 tccaaaaaga aacagcaata tgaagaagat tccaaagaaa cccttaaaac aagtgagcat   2100

 tgtgaaaagg aaaaaatttc ttcttcaaag gagctgaagc atgttcatgc aaaaagtgaa   2160

 ccaagtaaac ctgcccggag actttcagag tctttgcatg tagttgacga aaacaaaaat   2220

 gaatccaaaa tagaaagaga acataaaaga cggacatcta cccctgttat catggagggg   2280

 gtacaggaag agactgacac aagagatgta aaaaggcaag tagaacgctc agaaatttgc   2340

 accgaagagc cccagaaaca gaaaagcaca cttaaaaacg aaaagcatct aaagaaagat   2400

 gattctgaaa caccacattt gaaaagccta cttaagaaag aggtgaaatc ctccaaggag   2460

 aagcctgaaa gagagaaaac tccatcggaa gacaaattgt ctgtgaaaca taaatataaa   2520

 ggtgattgta tgcataaaac aggtgatgag actgagcttc actcttctga gaaaggttta   2580

 aaagtagagg aaaatattca aaagcaaagt caacaaacaa agctttcttc agatgataaa   2640

 accgaacgaa aaagtaaaca taggaatgaa aggaaattat cagtattagg caaagatgga   2700

 aagccagttt ctgaatatat tataaaaaca gatgagaatg ttcgtaaaaa aaaaaaaaaa   2760

 aaatgagaga cgcttgtcag ctgaaaaaac taaggcagag cacaaatcaa gaaggtcaag   2820

 tgattctaaa attcagaaag attctctggg ttccaagcaa catggtatca cattacagag   2880

 aagaagtgaa agttattcgg aagataagtg tgat    atg gac tcc act aac atg    2932
                                          Met Asp Ser Thr Asn Met
                                            1               5

 gat agt aat ttg aaa cca gaa gag gtt gtt cac aag gag aaa cga cga     2980
 Asp Ser Asn Leu Lys Pro Glu Glu Val Val His Lys Glu Lys Arg Arg
              10                  15                  20

 aca aag agc ttg tta gaa gag aaa ctt gtg ttg aag tct aaa tca aaa     3028
 Thr Lys Ser Leu Leu Glu Glu Lys Leu Val Leu Lys Ser Lys Ser Lys
          25                  30                  35

 act caa ggc aaa cag gta aaa gtt gta gaa aca gaa tta caa gaa ggt     3076
 Thr Gln Gly Lys Gln Val Lys Val Val Glu Thr Glu Leu Gln Glu Gly
      40                  45                  50

 gcc aca aaa cag gca acc act cca aaa cca gac aag gag aag aac aca     3124
 Ala Thr Lys Gln Ala Thr Thr Pro Lys Pro Asp Lys Glu Lys Asn Thr
  55                  60                  65                  70

 gaa gaa aat gac tca gaa aaa cag cgt aag tct aaa gtt gaa gac aaa     3172
 Glu Glu Asn Asp Ser Glu Lys Gln Arg Lys Ser Lys Val Glu Asp Lys
                  75                  80                  85

 cct ttt gaa gaa act ggt gtt gaa cct gta tta gag act gct tct tct     3220
 Pro Phe Glu Glu Thr Gly Val Glu Pro Val Leu Glu Thr Ala Ser Ser
              90                  95                 100

 tca gca cat agt aca cag aag gat tct agt cat aga gcc aag tta cca     3268
 Ser Ala His Ser Thr Gln Lys Asp Ser Ser His Arg Ala Lys Leu Pro
         105                 110                 115

 tta gca aag gag aaa tat aag agt gat aaa gac tcc act tcc acc agg     3316
 Leu Ala Lys Glu Lys Tyr Lys Ser Asp Lys Asp Ser Thr Ser Thr Arg
     120                 125                 130

 ctt gag aga aag ttg tca gat ggc cac aaa agc aga agc tta aag cat     3364
 Leu Glu Arg Lys Leu Ser Asp Gly His Lys Ser Arg Ser Leu Lys His
 135                 140                 145                 150

 agt agt aaa aac ata aaa aaa aag gac gaa aat aaa tca gat gac aag     3412
 Ser Ser Lys Asn Ile Lys Lys Lys Asp Glu Asn Lys Ser Asp Asp Lys
                 155                 160                 165

 gat ggt aaa gaa gtt gac agt agt cat gaa aag gcc aga ggt aat agt     3460
 Asp Gly Lys Glu Val Asp Ser Ser His Glu Lys Ala Arg Gly Asn Ser
             170                 175                 180

 tca ctc atg gaa aag aaa tta agt aga agg ttg tgc gaa aat cgg aga     3508
 Ser Leu Met Glu Lys Lys Leu Ser Arg Arg Leu Cys Glu Asn Arg Arg
         185                 190                 195

 gga agc ttg tca caa gaa atg gcc aaa gga gaa gaa aaa tta gca gca     3556
 Gly Ser Leu Ser Gln Glu Met Ala Lys Gly Glu Glu Lys Leu Ala Ala
     200                 205                 210

 aac act ttg agc act ccc agc ggt tcc tcc ctt cag aga cca aaa aag     3604
 Asn Thr Leu Ser Thr Pro Ser Gly Ser Ser Leu Gln Arg Pro Lys Lys
 215                 220                 225                 230

 agt ggt gat atg aca ttg atc cct gaa caa gag cca atg gaa att gat     3652
 Ser Gly Asp Met Thr Leu Ile Pro Glu Gln Glu Pro Met Glu Ile Asp
                 235                 240                 245

 tct gag cca ggt gtt gaa aat gtg ttt gaa gta tct aaa acc caa gac     3700
 Ser Glu Pro Gly Val Glu Asn Val Phe Glu Val Ser Lys Thr Gln Asp
             250                 255                 260

 aac cgc aat aat aat tct cag caa gac att gac tct gaa aat atg aaa     3748
 Asn Arg Asn Asn Asn Ser Gln Gln Asp Ile Asp Ser Glu Asn Met Lys
         265                 270                 275

 caa aaa act tct gcc act gtt caa aag gat gaa ttg aga act tgc aca     3796
 Gln Lys Thr Ser Ala Thr Val Gln Lys Asp Glu Leu Arg Thr Cys Thr
     280                 285                 290

 gca gat tca aaa gca aca gct cca gct tat aag cca ggc cgt gga aca     3844
 Ala Asp Ser Lys Ala Thr Ala Pro Ala Tyr Lys Pro Gly Arg Gly Thr
 295                 300                 305                 310

 gga gtt aat agt aat tct gaa aag cat gcc gat cat aga agc acc ttg     3892
 Gly Val Asn Ser Asn Ser Glu Lys His Ala Asp His Arg Ser Thr Leu
                 315                 320                 325

 acc aag aaa atg cat ata caa agt gct gtg tcc aaa atg aac cct ggg     3940
 Thr Lys Lys Met His Ile Gln Ser Ala Val Ser Lys Met Asn Pro Gly
             330                 335                 340

 gag aaa gaa ccc att cat aga gga act act gaa gtg aat ata gat tct     3988
 Glu Lys Glu Pro Ile His Arg Gly Thr Thr Glu Val Asn Ile Asp Ser
         345                 350                 355

 gaa act gtt cat aga atg tta ctg agt gcc cca tca gaa aat gat agg     4036
 Glu Thr Val His Arg Met Leu Leu Ser Ala Pro Ser Glu Asn Asp Arg
     360                 365                 370

 gta cag aag aat ttg aaa aac aca gct gct gaa gaa cat gtt gct caa     4084
 Val Gln Lys Asn Leu Lys Asn Thr Ala Ala Glu Glu His Val Ala Gln
 375                 380                 385                 390

 gga gat gcc act ctt gaa cat tcc aca aat tta gac tcc tca cca tcc     4132
 Gly Asp Ala Thr Leu Glu His Ser Thr Asn Leu Asp Ser Ser Pro Ser
                 395                 400                 405

 tta agt tca gtg act gtt gtg cct ctg agg gaa tcg tat gat cca gat     4180
 Leu Ser Ser Val Thr Val Val Pro Leu Arg Glu Ser Tyr Asp Pro Asp
             410                 415                 420

 gta att cct ctg ttt gac aaa aga act gtt ttg gaa ggt agc aca gcc     4228
 Val Ile Pro Leu Phe Asp Lys Arg Thr Val Leu Glu Gly Ser Thr Ala
         425                 430                 435

 agc acc tcc cct gcg gat cac tct gct ctc cct aac caa agt ctg act     4276
 Ser Thr Ser Pro Ala Asp His Ser Ala Leu Pro Asn Gln Ser Leu Thr
     440                 445                 450

 gtt agg gaa tca gaa gtc ctt aag aca agt gac agc aaa gaa ggt ggt     4324
 Val Arg Glu Ser Glu Val Leu Lys Thr Ser Asp Ser Lys Glu Gly Gly
 455                 460                 465                 470

 gaa ggt ttc aca gta gat aca cca gca aaa gca agc atc act agc aaa     4372
 Glu Gly Phe Thr Val Asp Thr Pro Ala Lys Ala Ser Ile Thr Ser Lys
                 475                 480                 485

 aga cac att cca gaa gct cac cag gct act tta ttg gat ggt aaa caa     4420
 Arg His Ile Pro Glu Ala His Gln Ala Thr Leu Leu Asp Gly Lys Gln
             490                 495                 500

 gga aag gta atc atg cct ctt gga agt aag tta acg ggc gtg att gtg     4468
 Gly Lys Val Ile Met Pro Leu Gly Ser Lys Leu Thr Gly Val Ile Val
         505                 510                 515

 gaa aat gag aat att acc aaa gaa ggt ggc tta gtg gac atg gcc aag     4516
 Glu Asn Glu Asn Ile Thr Lys Glu Gly Gly Leu Val Asp Met Ala Lys
     520                 525                 530

 aaa gaa aat gac tta aat gca gag ccc aat tta aag cag aca att aaa     4564
 Lys Glu Asn Asp Leu Asn Ala Glu Pro Asn Leu Lys Gln Thr Ile Lys
 535                 540                 545                 550

 gca aca gta gag aat ggc aag aag gat ggc att gct gtt gat cat gtt     4612
 Ala Thr Val Glu Asn Gly Lys Lys Asp Gly Ile Ala Val Asp His Val
                 555                 560                 565

 gta ggc ctg aat aca gaa aaa tat gct gaa act gtc aaa ctt aag cat     4660
 Val Gly Leu Asn Thr Glu Lys Tyr Ala Glu Thr Val Lys Leu Lys His
             570                 575                 580

 aaa aga agc cca ggt aaa gta aaa gac ata tca att gat gtt gaa aga     4708
 Lys Arg Ser Pro Gly Lys Val Lys Asp Ile Ser Ile Asp Val Glu Arg
         585                 590                 595

 agg aat gaa aac agt gag gta gac acc agt gct gga agt ggc tct gca     4756
 Arg Asn Glu Asn Ser Glu Val Asp Thr Ser Ala Gly Ser Gly Ser Ala
     600                 605                 610

 ccc tct gtt tta cac caa agg aac gga caa act gag gat gtg gca act     4804
 Pro Ser Val Leu His Gln Arg Asn Gly Gln Thr Glu Asp Val Ala Thr
 615                 620                 625                 630

 ggg cct agg aga gca gaa aag act tct gtt gcc act agt act gaa ggg     4852
 Gly Pro Arg Arg Ala Glu Lys Thr Ser Val Ala Thr Ser Thr Glu Gly
                 635                 640                 645

 aag gac aaa gat gtc acc tta agt cca gtg aag gct ggg cct gcc aca     4900
 Lys Asp Lys Asp Val Thr Leu Ser Pro Val Lys Ala Gly Pro Ala Thr
             650                 655                 660

 acc act tct tca gaa aca aga caa agt gag gtg gct ttg cct tgc acc     4948
 Thr Thr Ser Ser Glu Thr Arg Gln Ser Glu Val Ala Leu Pro Cys Thr
         665                 670                 675

 agc att gag gca gat gaa ggc ctc ata ata gga aca cat tcc aga aat     4996
 Ser Ile Glu Ala Asp Glu Gly Leu Ile Ile Gly Thr His Ser Arg Asn
     680                 685                 690

 aat cct ctt cat gtt ggt gca gaa gcc agt gaa tgc act gtt ttt gct     5044
 Asn Pro Leu His Val Gly Ala Glu Ala Ser Glu Cys Thr Val Phe Ala
 695                 700                 705                 710

 gca gct gaa gaa ggt ggg gct gtt gtc aca gag gga ttt gct gaa agt     5092
 Ala Ala Glu Glu Gly Gly Ala Val Val Thr Glu Gly Phe Ala Glu Ser
                 715                 720                 725

 gaa acc ttc ctc aca agc act aag gaa ggg gaa agt ggg gag tgt gct     5140
 Glu Thr Phe Leu Thr Ser Thr Lys Glu Gly Glu Ser Gly Glu Cys Ala
             730                 735                 740

 gtg gct gaa tct gag gac aga gca gca gac cta ctg gct gtg cat gca     5188
 Val Ala Glu Ser Glu Asp Arg Ala Ala Asp Leu Leu Ala Val His Ala
         745                 750                 755

 gtt aaa atc gaa gcc aat gta aat agc gtt gtg aca gag gaa aag gat     5236
 Val Lys Ile Glu Ala Asn Val Asn Ser Val Val Thr Glu Glu Lys Asp
     760                 765                 770

 gat gct gta acc agt gca ggc tct gaa gaa aaa tgt gat ggt tct tta     5284
 Asp Ala Val Thr Ser Ala Gly Ser Glu Glu Lys Cys Asp Gly Ser Leu
 775                 780                 785                 790

 agt aga gac tca gaa ata gtt gaa gga act att act ttt att agt gaa     5332
 Ser Arg Asp Ser Glu Ile Val Glu Gly Thr Ile Thr Phe Ile Ser Glu
                 795                 800                 805

 gtt gaa agt gat gga gca gtt aca agt gct gga aca gag ata aga gca     5380
 Val Glu Ser Asp Gly Ala Val Thr Ser Ala Gly Thr Glu Ile Arg Ala
             810                 815                 820

 gga tct ata agc agt gaa gag gtg gat ggc tcc cag gga aat atg atg     5428
 Gly Ser Ile Ser Ser Glu Glu Val Asp Gly Ser Gln Gly Asn Met Met
         825                 830                 835

 aga atg ggt ccc aaa aaa gaa aca gag ggc act gtg aca tgt aca gga     5476
 Arg Met Gly Pro Lys Lys Glu Thr Glu Gly Thr Val Thr Cys Thr Gly
     840                 845                 850

 gca gaa ggc aga agt gat aac ttt gtg atc tgc tca gta act gga gca     5524
 Ala Glu Gly Arg Ser Asp Asn Phe Val Ile Cys Ser Val Thr Gly Ala
 855                 860                 865                 870

 ggg ccc cgg gag gaa cgc atg gtt aca ggt gca ggt gtt gtc ctg gga     5572
 Gly Pro Arg Glu Glu Arg Met Val Thr Gly Ala Gly Val Val Leu Gly
                 875                 880                 885

 gat aat gat gca cca cca gga aca agt gcc agc caa gaa gga gat ggt     5620
 Asp Asn Asp Ala Pro Pro Gly Thr Ser Ala Ser Gln Glu Gly Asp Gly
             890                 895                 900

 tct gtg aat gat ggt aca gaa ggt gag agt gca gtc acc agc acg ggg     5668
 Ser Val Asn Asp Gly Thr Glu Gly Glu Ser Ala Val Thr Ser Thr Gly
         905                 910                 915

 ata aca gaa gat gga gag ggg cca gca agt tgc aca ggt tca gaa gat     5716
 Ile Thr Glu Asp Gly Glu Gly Pro Ala Ser Cys Thr Gly Ser Glu Asp
     920                 925                 930

 agc agc gaa ggc ttt gct ata agt tct gaa tcg gaa gaa aat gga gag     5764
 Ser Ser Glu Gly Phe Ala Ile Ser Ser Glu Ser Glu Glu Asn Gly Glu
 935                 940                 945                 950

 agt gca atg gac agc aca gtg gcc aaa gaa ggc act aat gta cca tta     5812
 Ser Ala Met Asp Ser Thr Val Ala Lys Glu Gly Thr Asn Val Pro Leu
                 955                 960                 965

 gtt gct gct ggt cct tgt gat gat gaa ggc att gtg act agc aca ggc     5860
 Val Ala Ala Gly Pro Cys Asp Asp Glu Gly Ile Val Thr Ser Thr Gly
             970                 975                 980

 gca aaa gag gaa gac gag gaa ggg gag gat gtt gtg act agt act gga     5908
 Ala Lys Glu Glu Asp Glu Glu Gly Glu Asp Val Val Thr Ser Thr Gly
         985                 990                 995

 aga gga aat gaa att ggg cat gct tca act tgt aca ggg tta gga gaa     5956
 Arg Gly Asn Glu Ile Gly His Ala Ser Thr Cys Thr Gly Leu Gly Glu
    1000                1005                1010

 gaa agt gaa ggg gtc ttg att tgt gaa agt gca gaa ggg gac agt cag     6004
 Glu Ser Glu Gly Val Leu Ile Cys Glu Ser Ala Glu Gly Asp Ser Gln
1015                1020                1025                1030

 att ggt act gtg gta gag cat gtg gaa gct gag gct gga gct gcc atc     6052
 Ile Gly Thr Val Val Glu His Val Glu Ala Glu Ala Gly Ala Ala Ile
                1035                1040                1045

 atg aat gca aat gaa aat aat gtt gac agc atg agt ggc aca gag aaa     6100
 Met Asn Ala Asn Glu Asn Asn Val Asp Ser Met Ser Gly Thr Glu Lys
            1050                1055                1060

 gga agt aaa gac aca gat atc tgc tcc agt gca aaa ggg att gta gaa     6148
 Gly Ser Lys Asp Thr Asp Ile Cys Ser Ser Ala Lys Gly Ile Val Glu
        1065                1070                1075

 agc agt gtg acc agt gca gtc tca gga aag gat gaa gtg aca cca gtt     6196
 Ser Ser Val Thr Ser Ala Val Ser Gly Lys Asp Glu Val Thr Pro Val
    1080                1085                1090

 cca gga ggt tgt gag ggt cct atg act agt gct gca tct gat caa agt     6244
 Pro Gly Gly Cys Glu Gly Pro Met Thr Ser Ala Ala Ser Asp Gln Ser
1095                1100                1105                1110

 gac agt cag ctc gaa aaa gtt gaa gat acc act att tcc act ggc ctg     6292
 Asp Ser Gln Leu Glu Lys Val Glu Asp Thr Thr Ile Ser Thr Gly Leu
                1115                1120                1125

 gtc ggg ggt agt tac gat gtt ctt gta tct ggt gaa gtc cca gaa tgt     6340
 Val Gly Gly Ser Tyr Asp Val Leu Val Ser Gly Glu Val Pro Glu Cys
            1130                1135                1140

 gaa gtt gct cac aca tca cca agt gaa aaa gaa gat gag gac atc atc     6388
 Glu Val Ala His Thr Ser Pro Ser Glu Lys Glu Asp Glu Asp Ile Ile
        1145                1150                1155

 acc tct gta gaa aat gaa gag tgt gat ggt ctc atg gca act aca gcc     6436
 Thr Ser Val Glu Asn Glu Glu Cys Asp Gly Leu Met Ala Thr Thr Ala
    1160                1165                1170

 agt ggt gat att acc aac cag aat agc tta gca ggg ggt aaa aat caa     6484
 Ser Gly Asp Ile Thr Asn Gln Asn Ser Leu Ala Gly Gly Lys Asn Gln
1175                1180                1185                1190

 ggc aaa gtt ttg att att tcc acc agt acc aca aat gat tac acc cct     6532
 Gly Lys Val Leu Ile Ile Ser Thr Ser Thr Thr Asn Asp Tyr Thr Pro
                1195                1200                1205

 cag gta agc gca att aca gat gtg gaa gga ggt ctc tca gat gct ctg     6580
 Gln Val Ser Ala Ile Thr Asp Val Glu Gly Gly Leu Ser Asp Ala Leu
            1210                1215                1220

 aga act gaa gaa aat atg gaa ggt acc aga gta acc aca gaa gaa ttt     6628
 Arg Thr Glu Glu Asn Met Glu Gly Thr Arg Val Thr Thr Glu Glu Phe
        1225                1230                1235

 gag gcc ccc atg ccc agt gca gtc tca gga gat gac agc caa ctc act     6676
 Glu Ala Pro Met Pro Ser Ala Val Ser Gly Asp Asp Ser Gln Leu Thr
    1240                1245                1250

 gcc agc aga agt gaa gag aaa gat gag tgt gcc atg att tcc aca agc     6724
 Ala Ser Arg Ser Glu Glu Lys Asp Glu Cys Ala Met Ile Ser Thr Ser
1255                1260                1265                1270

 ata ggg gaa gaa ttc gaa ttg cct atc tcc agt gca aca acc atc aag     6772
 Ile Gly Glu Glu Phe Glu Leu Pro Ile Ser Ser Ala Thr Thr Ile Lys
                1275                1280                1285

 tgt gct gaa agt ctt cag ccg gtt gct gca gca gtg gaa gaa agg gct     6820
 Cys Ala Glu Ser Leu Gln Pro Val Ala Ala Ala Val Glu Glu Arg Ala
            1290                1295                1300

 aca ggt cca gtc ttg ata agc acc gcc gac ttt gag ggg cct atg ccc     6868
 Thr Gly Pro Val Leu Ile Ser Thr Ala Asp Phe Glu Gly Pro Met Pro
        1305                1310                1315

 agt gcg ccc cca gaa gct gaa agt cct ctt gcc tca acc agc aag gag     6916
 Ser Ala Pro Pro Glu Ala Glu Ser Pro Leu Ala Ser Thr Ser Lys Glu
    1320                1325                1330

 gag aag gat gaa tgt gct ctc att tcc act agc ata gca gaa gaa tgt     6964
 Glu Lys Asp Glu Cys Ala Leu Ile Ser Thr Ser Ile Ala Glu Glu Cys
1335                1340                1345                1350

 gag gct tct gtt tcc ggt gta gtt gtt gaa agt gaa aat gag cga gct     7012
 Glu Ala Ser Val Ser Gly Val Val Val Glu Ser Glu Asn Glu Arg Ala
                1355                1360                1365

 ggc aca gtc atg gaa gaa aaa gac ggg agt ggc atc atc tct acg agc     7060
 Gly Thr Val Met Glu Glu Lys Asp Gly Ser Gly Ile Ile Ser Thr Ser
            1370                1375                1380

 tcg gtg gaa gac tgt gag ggc cca gtg tcc agt gct gtc cct caa gag     7108
 Ser Val Glu Asp Cys Glu Gly Pro Val Ser Ser Ala Val Pro Gln Glu
        1385                1390                1395

 gaa ggc gac ccc tca gtc aca cca gcg gaa gag atg ggt gac acc gcc     7156
 Glu Gly Asp Pro Ser Val Thr Pro Ala Glu Glu Met Gly Asp Thr Ala
    1400                1405                1410

 atg att tcc aca agc acc tct gaa ggg tgt gaa gca gtc atg att ggt     7204
 Met Ile Ser Thr Ser Thr Ser Glu Gly Cys Glu Ala Val Met Ile Gly
1415                1420                1425                1430

 gct gtc ctc cag gat gaa gat cgg ctc acc atc aca aga gta gaa gac     7252
 Ala Val Leu Gln Asp Glu Asp Arg Leu Thr Ile Thr Arg Val Glu Asp
                1435                1440                1445

 ttg agc gat gct gcc atc atc tcc acc agc aca gca gaa tgt atg cca     7300
 Leu Ser Asp Ala Ala Ile Ile Ser Thr Ser Thr Ala Glu Cys Met Pro
            1450                1455                1460

 att tcc gcc agc att gac aga cat gaa gag aat cag ctg act gca gac     7348
 Ile Ser Ala Ser Ile Asp Arg His Glu Glu Asn Gln Leu Thr Ala Asp
        1465                1470                1475

 aac cca gaa ggg aac ggt gac ctg tca gcc aca gaa gtg agc aag cac     7396
 Asn Pro Glu Gly Asn Gly Asp Leu Ser Ala Thr Glu Val Ser Lys His
    1480                1485                1490

 aag gtc ccc atg ccc agc cta att gct gag aat aac tgt cgg tgt cct     7444
 Lys Val Pro Met Pro Ser Leu Ile Ala Glu Asn Asn Cys Arg Cys Pro
1495                1500                1505                1510

 ggg cca gtc agg gga ggc aaa gaa ccg ggt ccc gtg ttg gca gtg agc     7492
 Gly Pro Val Arg Gly Gly Lys Glu Pro Gly Pro Val Leu Ala Val Ser
                1515                1520                1525

 acc gag gag ggg cac aac ggg cca tca gtc cac aag ccc tct gca ggg     7540
 Thr Glu Glu Gly His Asn Gly Pro Ser Val His Lys Pro Ser Ala Gly
            1530                1535                1540

 caa ggc cat cca agt gct gtt tgt gcg gaa aaa gaa gag aag cat ggc     7588
 Gln Gly His Pro Ser Ala Val Cys Ala Glu Lys Glu Glu Lys His Gly
        1545                1550                1555

 aag gag tgc ccc gaa ata gga cca ttt gca gga aga gga cag aaa gag     7636
 Lys Glu Cys Pro Glu Ile Gly Pro Phe Ala Gly Arg Gly Gln Lys Glu
    1560                1565                1570

 agc act tta cac ctc ata aat gca gaa gag aag aat gta ttg ttg aac     7684
 Ser Thr Leu His Leu Ile Asn Ala Glu Glu Lys Asn Val Leu Leu Asn
1575                1580                1585                1590

 tcc ctt cag aaa gaa gat aag agc cca gag aca ggg aca gca ggg ggc     7732
 Ser Leu Gln Lys Glu Asp Lys Ser Pro Glu Thr Gly Thr Ala Gly Gly
                1595                1600                1605

 agt agc aca gca agt tat tca gca gga agg ggc tta gag ggg aat gct     7780
 Ser Ser Thr Ala Ser Tyr Ser Ala Gly Arg Gly Leu Glu Gly Asn Ala
            1610                1615                1620

 aac tca cct gcc cac ctg aga gga cca gaa cag acg tct ggg cag acg     7828
 Asn Ser Pro Ala His Leu Arg Gly Pro Glu Gln Thr Ser Gly Gln Thr
        1625                1630                1635

 gct aag gat tcc tct gtc agc agc att cgc tat ttg gca gca gta aac     7876
 Ala Lys Asp Ser Ser Val Ser Ser Ile Arg Tyr Leu Ala Ala Val Asn
    1640                1645                1650

 acc ggt gct ata aaa gct gat gac atg cca cct gtt caa ggg acc gtg     7924
 Thr Gly Ala Ile Lys Ala Asp Asp Met Pro Pro Val Gln Gly Thr Val
1655                1660                1665                1670

 gct gag cat tcc ttt ctt cct gct gag cag cag ggg tct gaa gac aac     7972
 Ala Glu His Ser Phe Leu Pro Ala Glu Gln Gln Gly Ser Glu Asp Asn
                1675                1680                1685

 ttg aaa acc agt acc acc aaa tgt att act ggc caa gaa tca aaa att     8020
 Leu Lys Thr Ser Thr Thr Lys Cys Ile Thr Gly Gln Glu Ser Lys Ile
            1690                1695                1700

 gct cct tcc cac aca atg atc cct cca gct act tac agt gta gct ctg     8068
 Ala Pro Ser His Thr Met Ile Pro Pro Ala Thr Tyr Ser Val Ala Leu
        1705                1710                1715

 ttg gct cct aaa tgt gag cag gac ttg act ata aag aat gat tat agt     8116
 Leu Ala Pro Lys Cys Glu Gln Asp Leu Thr Ile Lys Asn Asp Tyr Ser
    1720                1725                1730

 ggc aaa tgg act gat caa gca tct gct gag aaa aca gga gat gat aac     8164
 Gly Lys Trp Thr Asp Gln Ala Ser Ala Glu Lys Thr Gly Asp Asp Asn
1735                1740                1745                1750

 agc aca agg aaa tca ttc cct gag gaa gga gac ata atg gtt act gtg     8212
 Ser Thr Arg Lys Ser Phe Pro Glu Glu Gly Asp Ile Met Val Thr Val
                1755                1760                1765

 tct tct gaa gaa aat gct tat gtg cct tca gag gaa gag aaa aat ggt     8260
 Ser Ser Glu Glu Asn Ala Tyr Val Pro Ser Glu Glu Glu Lys Asn Gly
            1770                1775                1780

 gaa att ctg gca cca cca gaa agt ctg tgt ggg gga aag cca agt gga     8308
 Glu Ile Leu Ala Pro Pro Glu Ser Leu Cys Gly Gly Lys Pro Ser Gly
        1785                1790                1795

 ata gag ata tcc agt ggt aga aaa gac aac gca gaa gcc ata agc ggt     8356
 Ile Glu Ile Ser Ser Gly Arg Lys Asp Asn Ala Glu Ala Ile Ser Gly
    1800                1805                1810

 cac agt gtt gaa gca gat cct aaa gag gaa gag aac tcc aga gat ttg     8404
 His Ser Val Glu Ala Asp Pro Lys Glu Glu Glu Asn Ser Arg Asp Leu
1815                1820                1825                1830

 gaa gaa tta cct aaa acc agt tct gag aca aat agc act acc tca agg     8452
 Glu Glu Leu Pro Lys Thr Ser Ser Glu Thr Asn Ser Thr Thr Ser Arg
                1835                1840                1845

 gtc atg gaa gaa aaa gat gaa tat agc agc agt gaa act act ggt gaa     8500
 Val Met Glu Glu Lys Asp Glu Tyr Ser Ser Ser Glu Thr Thr Gly Glu
            1850                1855                1860

 aag cca gag cag aac gat gat gac acc ata aaa tct cag gag gat gat     8548
 Lys Pro Glu Gln Asn Asp Asp Asp Thr Ile Lys Ser Gln Glu Asp Asp
        1865                1870                1875

 ggt gaa gaa aaa ata gta aca agt gtg cgt cgg aga gga aga aaa ccc     8596
 Gly Glu Glu Lys Ile Val Thr Ser Val Arg Arg Arg Gly Arg Lys Pro
    1880                1885                1890

 aaa cgt tct ctc act gta tca gat gat gct gaa tcc tca gag cca gaa     8644
 Lys Arg Ser Leu Thr Val Ser Asp Asp Ala Glu Ser Ser Glu Pro Glu
1895                1900                1905                1910

 aga aaa cgc cag aaa tca gtt tct gat cca gtg gag gac aag aaa gag     8692
 Arg Lys Arg Gln Lys Ser Val Ser Asp Pro Val Glu Asp Lys Lys Glu
                1915                1920                1925

 cag gag tct gat gag gaa gag gaa gaa gag gaa gag gac gag cct tca     8740
 Gln Glu Ser Asp Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Pro Ser
            1930                1935                1940

 gga gcc acc aca aga tcc acc acc aga tca gag gct cag aga tca aag     8788
 Gly Ala Thr Thr Arg Ser Thr Thr Arg Ser Glu Ala Gln Arg Ser Lys
        1945                1950                1955

 aca cag ctc tcc cct tct atc aag cgc aag aga gaa gtc agc cct cct     8836
 Thr Gln Leu Ser Pro Ser Ile Lys Arg Lys Arg Glu Val Ser Pro Pro
    1960                1965                1970

 ggg gcc cga aca aga ggc cag caa agg gtg gag gaa gcc cct gtg aaa     8884
 Gly Ala Arg Thr Arg Gly Gln Gln Arg Val Glu Glu Ala Pro Val Lys
1975                1980                1985                1990

 aaa gcg aag cga taa tcctgaccac tgctgcccta ggcttatgga ggaacacggt     8939
 Lys Ala Lys Arg 


 ggagaggaaa gagacatgcc ttggtggcca taggcttctc tttaaccagg aaaaagatat   8999

 gcatgtgctg taagtcccta gggtgcaagc tttttcttgt tatgttttaa acagctttat   9059

 aaactattgt tg                                                       9071




      <210> 124
      <211> 1519
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (131)..(1516)

      <400> 124
 cggaagtgga cgaatttgaa tcctgtgggc cgttgaatgt ggctgctcgc ggtcggcgtg     60

 ccccgacgta cagcgggccg ggaaaagtgg cactgaggct ctggaacttc tgcccagctc    120

 tccttgtaaa   atg aat gaa agt aaa cct ggt gac tca cag aac ctt gct     169
              Met Asn Glu Ser Lys Pro Gly Asp Ser Gln Asn Leu Ala
                1               5                  10

 tgt gtt ttc tgt cga aaa cat gat gac tgt cct aat aaa tac gga gaa      217
 Cys Val Phe Cys Arg Lys His Asp Asp Cys Pro Asn Lys Tyr Gly Glu
      15                  20                  25

 aag aaa act aag gag aaa tgg aat ctc act gta cat tac tac tgt ttg      265
 Lys Lys Thr Lys Glu Lys Trp Asn Leu Thr Val His Tyr Tyr Cys Leu
  30                  35                  40                  45

 ttg atg tca agt gga att tgg cag aga ggc aaa gaa gaa gaa gga gtt      313
 Leu Met Ser Ser Gly Ile Trp Gln Arg Gly Lys Glu Glu Glu Gly Val
                  50                  55                  60

 tat ggt ttt cta ata gaa gat atc agg aag gaa gtg aat aga gct tct      361
 Tyr Gly Phe Leu Ile Glu Asp Ile Arg Lys Glu Val Asn Arg Ala Ser
              65                  70                  75

 aaa ctg gtt caa gca ata aat gcg gga gtg ttt ttc ttt agg tgt aca      409
 Lys Leu Val Gln Ala Ile Asn Ala Gly Val Phe Phe Phe Arg Cys Thr
          80                  85                  90

 ata tgc aat aat agt gac atc ttt cag aaa gag atg ttg aga atg gga      457
 Ile Cys Asn Asn Ser Asp Ile Phe Gln Lys Glu Met Leu Arg Met Gly
      95                 100                 105

 att cat att cct gaa aaa gat gct tcc tgg gaa tta gag gaa aac gct      505
 Ile His Ile Pro Glu Lys Asp Ala Ser Trp Glu Leu Glu Glu Asn Ala
 110                 115                 120                 125

 tat caa gag ctt ctg cag cac tat gag cgt tgt gat gtt cga aga tgt      553
 Tyr Gln Glu Leu Leu Gln His Tyr Glu Arg Cys Asp Val Arg Arg Cys
                 130                 135                 140

 cgt tgc aaa gaa ggg cga gac tat aat gca cct gac agc aaa tgg gaa      601
 Arg Cys Lys Glu Gly Arg Asp Tyr Asn Ala Pro Asp Ser Lys Trp Glu
             145                 150                 155

 ata aag cgc tgt cag tgt tgt ggt tcc agt ggc aca cat tta gcc tgc      649
 Ile Lys Arg Cys Gln Cys Cys Gly Ser Ser Gly Thr His Leu Ala Cys
         160                 165                 170

 tcc tca tta cgg tca tgg gag caa aat tgg gag tgt ttg gaa tgt agg      697
 Ser Ser Leu Arg Ser Trp Glu Gln Asn Trp Glu Cys Leu Glu Cys Arg
     175                 180                 185

 ggt att atc tac aat tca gct ctg aaa gag aat ctt tac tat gaa gct      745
 Gly Ile Ile Tyr Asn Ser Ala Leu Lys Glu Asn Leu Tyr Tyr Glu Ala
 190                 195                 200                 205

 ggc aaa atg ctt gcc att tct tta gtt cac ggt ggt cct tca cct ggt      793
 Gly Lys Met Leu Ala Ile Ser Leu Val His Gly Gly Pro Ser Pro Gly
                 210                 215                 220

 ttc ttt tct aaa acc ttg ttt aac tgc ctt gtt tat gga cca gaa aat      841
 Phe Phe Ser Lys Thr Leu Phe Asn Cys Leu Val Tyr Gly Pro Glu Asn
             225                 230                 235

 acc cag cca att tta gat gat gtt tca gac ttt gat gtg gca cag att      889
 Thr Gln Pro Ile Leu Asp Asp Val Ser Asp Phe Asp Val Ala Gln Ile
         240                 245                 250

 ata atc agg ata aat act gca aca act gta gct gac tta aag tca ata      937
 Ile Ile Arg Ile Asn Thr Ala Thr Thr Val Ala Asp Leu Lys Ser Ile
     255                 260                 265

 ata aat gaa tgc tat aac tac ctt gag tta att gga tgt ctc aga ctt      985
 Ile Asn Glu Cys Tyr Asn Tyr Leu Glu Leu Ile Gly Cys Leu Arg Leu
 270                 275                 280                 285

 ata acg aca tta agt gat aaa tat atg tta gta aaa gac ata ctt ggc     1033
 Ile Thr Thr Leu Ser Asp Lys Tyr Met Leu Val Lys Asp Ile Leu Gly
                 290                 295                 300

 tac cat gta att cag aga gtc cac aca ccc ttt gaa agt ttt aag cag     1081
 Tyr His Val Ile Gln Arg Val His Thr Pro Phe Glu Ser Phe Lys Gln
             305                 310                 315

 ggt ctg aaa acc ctt ggt gtt ttg gag aaa att cag gct tat cca gaa     1129
 Gly Leu Lys Thr Leu Gly Val Leu Glu Lys Ile Gln Ala Tyr Pro Glu
         320                 325                 330

 gca ttt tgt agc atc ctg tgt cat aaa cct gag agt ctt tct gca aaa     1177
 Ala Phe Cys Ser Ile Leu Cys His Lys Pro Glu Ser Leu Ser Ala Lys
     335                 340                 345

 atc ctt agt gag ctt ttt aca gta cac aca tta cct gat gtg aaa gct     1225
 Ile Leu Ser Glu Leu Phe Thr Val His Thr Leu Pro Asp Val Lys Ala
 350                 355                 360                 365

 ttg ggg ttt tgg aac agt tac tta cag gct gtt gaa gat ggt aaa tct     1273
 Leu Gly Phe Trp Asn Ser Tyr Leu Gln Ala Val Glu Asp Gly Lys Ser
                 370                 375                 380

 aca aca aca atg gaa gac att ctt att ttt gca act ggt tgc agt tcc     1321
 Thr Thr Thr Met Glu Asp Ile Leu Ile Phe Ala Thr Gly Cys Ser Ser
             385                 390                 395

 att cct cca gct gga ttt aaa ccc act cct tca att gag tgt ctg cat     1369
 Ile Pro Pro Ala Gly Phe Lys Pro Thr Pro Ser Ile Glu Cys Leu His
         400                 405                 410

 gtg gat ttt cct gtt gga aac aag tgt aat aac tgt tta gca att ccc     1417
 Val Asp Phe Pro Val Gly Asn Lys Cys Asn Asn Cys Leu Ala Ile Pro
     415                 420                 425

 atc acc aat aca tat aaa gag ttt caa gaa aat atg gac ttc acc ata     1465
 Ile Thr Asn Thr Tyr Lys Glu Phe Gln Glu Asn Met Asp Phe Thr Ile
 430                 435                 440                 445

 aga aac act cta aga cta gaa aag gaa gaa agt tct cat tac att gga     1513
 Arg Asn Thr Leu Arg Leu Glu Lys Glu Glu Ser Ser His Tyr Ile Gly
                 450                 455                 460

 cat taa                                                             1519
 His 






      <210> 125
      <211> 3158
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (100)..(1812)

      <400> 125
 ccggctacgg gtccccaagc ggagcgggag gccggaccgg ggagccgagc ggcggcgtcg     60

 gcggcgtcgg cggcggcggc gacggcggcg ggggcggta   atg gcg gag ctg gtg     114
                                              Met Ala Glu Leu Val
                                                1               5

 cag ggg cag agc gct cct gtg ggg atg aag gcc gag ggc ttc gtg gat      162
 Gln Gly Gln Ser Ala Pro Val Gly Met Lys Ala Glu Gly Phe Val Asp
                  10                  15                  20

 gcc ctg cac cgg gtc cgg cag att gct gct aaa att gat tca att cct      210
 Ala Leu His Arg Val Arg Gln Ile Ala Ala Lys Ile Asp Ser Ile Pro
              25                  30                  35

 cac ttg aat aat tcc aca cct cta gtg gac ccc tca gta tat gga tac      258
 His Leu Asn Asn Ser Thr Pro Leu Val Asp Pro Ser Val Tyr Gly Tyr
          40                  45                  50

 gga gta caa aaa cgg ccc ttg gat gat gga ggt aac cag tta ggg gcc      306
 Gly Val Gln Lys Arg Pro Leu Asp Asp Gly Gly Asn Gln Leu Gly Ala
      55                  60                  65

 ttg gta cat caa agg acg gta ata acg gaa gaa ttc aaa gtg cct gac      354
 Leu Val His Gln Arg Thr Val Ile Thr Glu Glu Phe Lys Val Pro Asp
  70                  75                  80                  85

 aaa atg gtt gga ttt att atc ggc agg gga ggt gag cag att tca cgg      402
 Lys Met Val Gly Phe Ile Ile Gly Arg Gly Gly Glu Gln Ile Ser Arg
                  90                  95                 100

 att caa gca gaa tct ggt tgc aaa att cag att gct tca gag agt tct      450
 Ile Gln Ala Glu Ser Gly Cys Lys Ile Gln Ile Ala Ser Glu Ser Ser
             105                 110                 115

 ggg att cca gag agg ccc tgt gta ctt acc gga acc cca gaa agt att      498
 Gly Ile Pro Glu Arg Pro Cys Val Leu Thr Gly Thr Pro Glu Ser Ile
         120                 125                 130

 gaa caa gcc aaa cgg ctc ctg gga cag att gtg gac cgc tgt cga aat      546
 Glu Gln Ala Lys Arg Leu Leu Gly Gln Ile Val Asp Arg Cys Arg Asn
     135                 140                 145

 gga cct ggc ttt cat aat gac ata gac agc aac agc aca atc cag gag      594
 Gly Pro Gly Phe His Asn Asp Ile Asp Ser Asn Ser Thr Ile Gln Glu
 150                 155                 160                 165

 att ctc att ccc gca tct aaa gtg ggt ctg gtc atc ggc aga gga ggg      642
 Ile Leu Ile Pro Ala Ser Lys Val Gly Leu Val Ile Gly Arg Gly Gly
                 170                 175                 180

 gaa aca atc aag cag ttg cag gag cgg aca ggg gtg aag atg gtc atg      690
 Glu Thr Ile Lys Gln Leu Gln Glu Arg Thr Gly Val Lys Met Val Met
             185                 190                 195

 atc cag gat ggc cca ttg ccc acg gga gca gac aag cct ctt cgt atc      738
 Ile Gln Asp Gly Pro Leu Pro Thr Gly Ala Asp Lys Pro Leu Arg Ile
         200                 205                 210

 act gga gat gca ttt aaa gta cag caa gca aga gaa atg gta cta gag      786
 Thr Gly Asp Ala Phe Lys Val Gln Gln Ala Arg Glu Met Val Leu Glu
     215                 220                 225

 att atc cga gaa aaa gac caa gct gac ttt cgg ggt gta cgc ggc gat      834
 Ile Ile Arg Glu Lys Asp Gln Ala Asp Phe Arg Gly Val Arg Gly Asp
 230                 235                 240                 245

 ttc aac tct cga atg gga gga ggc agt ata gag gta tct gtg cct agg      882
 Phe Asn Ser Arg Met Gly Gly Gly Ser Ile Glu Val Ser Val Pro Arg
                 250                 255                 260

 ttt gct gtg ggg att gta ata gga aga aac ggg gaa atg atc aaa aag      930
 Phe Ala Val Gly Ile Val Ile Gly Arg Asn Gly Glu Met Ile Lys Lys
             265                 270                 275

 atc cag aat gat gct ggt gtg agg att cag ttt aaa cca gat gat ggg      978
 Ile Gln Asn Asp Ala Gly Val Arg Ile Gln Phe Lys Pro Asp Asp Gly
         280                 285                 290

 att agt cca gaa aga gct gcc cag gtc atg ggc cct ccg gat cgg tgt     1026
 Ile Ser Pro Glu Arg Ala Ala Gln Val Met Gly Pro Pro Asp Arg Cys
     295                 300                 305

 cag cat gca gcg cat atc atc agc gag ctg att ctt aca gcc cag gaa     1074
 Gln His Ala Ala His Ile Ile Ser Glu Leu Ile Leu Thr Ala Gln Glu
 310                 315                 320                 325

 aga gac ggc ttt gga ggc ctg gca gca gcc aga gga aga ggt cgt ggc     1122
 Arg Asp Gly Phe Gly Gly Leu Ala Ala Ala Arg Gly Arg Gly Arg Gly
                 330                 335                 340

 cgt ggc gac tgg agc gtg gga gcc cct ggt ggc gtc cag gag ata aca     1170
 Arg Gly Asp Trp Ser Val Gly Ala Pro Gly Gly Val Gln Glu Ile Thr
             345                 350                 355

 tac acg gtg cca gcc gat aag tgt ggc ctc gtc ata ggc aaa ggg ggt     1218
 Tyr Thr Val Pro Ala Asp Lys Cys Gly Leu Val Ile Gly Lys Gly Gly
         360                 365                 370

 gag aac atc aaa agc atc aac cag cag tca ggg gcg cac gtg gag ctt     1266
 Glu Asn Ile Lys Ser Ile Asn Gln Gln Ser Gly Ala His Val Glu Leu
     375                 380                 385

 cag agg aac ccc cct ccc aac agc gac ccc aac ctg cgg aga ttc acc     1314
 Gln Arg Asn Pro Pro Pro Asn Ser Asp Pro Asn Leu Arg Arg Phe Thr
 390                 395                 400                 405

 atc agg ggg gtt ccc cag cag atc gag gtg gcc agg cag ctc ata gat     1362
 Ile Arg Gly Val Pro Gln Gln Ile Glu Val Ala Arg Gln Leu Ile Asp
                 410                 415                 420

 gag aaa gtt ggc ggg acc aat ctc gga gca cct gga gcc ttc gga cag     1410
 Glu Lys Val Gly Gly Thr Asn Leu Gly Ala Pro Gly Ala Phe Gly Gln
             425                 430                 435

 agt cca ttc agc cag cca cct gcc cca cct cat caa aat acc ttt cct     1458
 Ser Pro Phe Ser Gln Pro Pro Ala Pro Pro His Gln Asn Thr Phe Pro
         440                 445                 450

 cca agg agc tcc ggg tgc ttc cca aac atg gct gcc aag gtg aat ggg     1506
 Pro Arg Ser Ser Gly Cys Phe Pro Asn Met Ala Ala Lys Val Asn Gly
     455                 460                 465

 aac ccc cac agc acc cct gtg agt ggt cct ccg gcc ttt ctg acc cag     1554
 Asn Pro His Ser Thr Pro Val Ser Gly Pro Pro Ala Phe Leu Thr Gln
 470                 475                 480                 485

 ggc tgg ggc agc acc tac cag gcg tgg cag cag ccc aca cag cag gtc     1602
 Gly Trp Gly Ser Thr Tyr Gln Ala Trp Gln Gln Pro Thr Gln Gln Val
                 490                 495                 500

 cca agc cag cag agc cag ccg cag agc agc cag ccc aac tac agc aag     1650
 Pro Ser Gln Gln Ser Gln Pro Gln Ser Ser Gln Pro Asn Tyr Ser Lys
             505                 510                 515

 gcc tgg gaa gac tat tac aaa aaa cag agt cac gcc gcc agc gct gct     1698
 Ala Trp Glu Asp Tyr Tyr Lys Lys Gln Ser His Ala Ala Ser Ala Ala
         520                 525                 530

 cct cag gcc agc tcc cca ccg gac tac aca atg gcc tgg gca gaa tat     1746
 Pro Gln Ala Ser Ser Pro Pro Asp Tyr Thr Met Ala Trp Ala Glu Tyr
     535                 540                 545

 tac aga cag cag gtc gct ttc tac gga cag acg tta ggg cag gcg cag     1794
 Tyr Arg Gln Gln Val Ala Phe Tyr Gly Gln Thr Leu Gly Gln Ala Gln
 550                 555                 560                 565

 gcc cac agc cag gag cag taggac agcgtcctcg tggccaactc tcccctcaaa     1848
 Ala His Ser Gln Glu Gln 
                 570

 atcattgtca aagaaaacct atttgtaaca gaggttttta catttgcaaa ccttttgatg   1908

 aagaactgtt gttttgttct gtgaaacact atatttagat taacggaatt tttctaaaaa   1968

 tcaggaaaat tagttactaa aaattgctga tcatttttgt ttcattattt ttgttatttc   2028

 aaatgtataa gctctgggat tctttttgga gcaataccta caaagtcagg caccagaatg   2088

 tgcctcagag ctgtgacatt tcaacatgat ggttttggtt tggtttggtt ttgtgtcctt   2148

 tttatttgca gttttttctg ttgcaacaga aagtggcttg gaagtcttag gtggtatgta   2208

 acaaattctt tttaaaaatt ttaaagcagt atttaagtat tcttaaatgt gtaaattcat   2268

 ttaatgtttt acttctaatt tcttgtatct tggctgtctg gttttattgc atttttaaaa   2328

 aaactgaact attatgtatt gtaatgaatg atgtgaattc tgaactgaga cagataattg   2388

 tattgctgtc caacaggggt tgggaggggc attttgtagg gtttgtataa tttctagagt   2448

 tcgaaagggg taatataaaa atgtgctcgt gtgtttagcc tacgtttttc tcatgcctcc   2508

 attaccagtt gcaattgtgt atctaagacc tccaagcttg tttttaaaac aaaacaaaaa   2568

 acctttctct attatctcag aaatataaat actgttattt ttaatattaa gaaattcaat   2628

 ataactttta acacacactg tggaacatta aaccgtataa aaatgtagtt ataactattt   2688

 ttaattccaa ggtgttgttt gcttttttct tttaaatatt ttcttaatat tttgtcagat   2748

 taactagatg aataaataaa tctagtatta accgcattat gaattaaata attttgattt   2808

 aatgaaaggg ataatatgat ttccagtgtt tactgtagtg tatcttgtac agataacatg   2868

 tatttttaaa ggaaaaaaaa cggaattgaa gctatttttt cttgcatttc taattgacct   2928

 gagggacatt ccgtttgaaa tgtactgaag ttacagtttc tggttttttc tccttatttt   2988

 tcttataatg cttgaaatgt ctaactatta aaaaagacaa ttggaaaatg ttatgcatgg   3048

 ggtttttaag aaaacaaagt gttcttttta tttgactgac aattcatttt acactctata   3108

 taataaaatc tccacaaggc atcttgtggg caaagtcaaa aaaaaaaaaa              3158




      <210> 126
      <211> 3236
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (133)..(2880)

      <400> 126
 tttgaaaatg tgttttttga ggtggaatac ccaactgacc cctcatctct cctctctctc     60

 tgctgccctg cagtgctaca gttgaaactc cagcagcgcc ggacccggga agaactggtg    120

 agccaaggga tc    atg ccg cct ttg aaa agt cca gcc gca ttt cat gag     168
                  Met Pro Pro Leu Lys Ser Pro Ala Ala Phe His Glu
                    1               5                  10

 cag aga agg agc ttg gag cgg gcc agg aca gag gac tat ctc aaa cgg      216
 Gln Arg Arg Ser Leu Glu Arg Ala Arg Thr Glu Asp Tyr Leu Lys Arg
          15                  20                  25

 aag att cgt tcc cgg ccg gag aga tcg gag ctg gtc agg atg cac att      264
 Lys Ile Arg Ser Arg Pro Glu Arg Ser Glu Leu Val Arg Met His Ile
      30                  35                  40

 ttg gaa gag acc tcg gct gag cca tcc ctc cag gcc aag cag ctg aag      312
 Leu Glu Glu Thr Ser Ala Glu Pro Ser Leu Gln Ala Lys Gln Leu Lys
  45                  50                  55                  60

 ctg aag aga gcc aga cta gcc gat gac ctc aat gag aag att gca cag      360
 Leu Lys Arg Ala Arg Leu Ala Asp Asp Leu Asn Glu Lys Ile Ala Gln
                  65                  70                  75

 agg cct ggc ccc atg gag ctg gtg gag aag aac atc ctt cct gtt gag      408
 Arg Pro Gly Pro Met Glu Leu Val Glu Lys Asn Ile Leu Pro Val Glu
              80                  85                  90

 tcc agc ctg aag gaa gcc atc att gtg ggc cag gtg aac tat ccc aaa      456
 Ser Ser Leu Lys Glu Ala Ile Ile Val Gly Gln Val Asn Tyr Pro Lys
          95                 100                 105

 gta gca gac agc tct tcc ttc gat gag gac agc agc gat gcc tta tcc      504
 Val Ala Asp Ser Ser Ser Phe Asp Glu Asp Ser Ser Asp Ala Leu Ser
     110                 115                 120

 ccc gag cag cct gcc agc cat gag tcc cag ggt tct gtg ccg tca ccc      552
 Pro Glu Gln Pro Ala Ser His Glu Ser Gln Gly Ser Val Pro Ser Pro
 125                 130                 135                 140

 ctg gag gcc cga gtc agc gaa cca ctg ctc agt gcc acc tct gca tcc      600
 Leu Glu Ala Arg Val Ser Glu Pro Leu Leu Ser Ala Thr Ser Ala Ser
                 145                 150                 155

 ccc acc cag gtt gtg tct caa ctt ccg atg ggc cgg gat tcc aga gaa      648
 Pro Thr Gln Val Val Ser Gln Leu Pro Met Gly Arg Asp Ser Arg Glu
             160                 165                 170

 atg ctt ttc ctg gca gag cag cct cct ctg cct ccc cca cct ctg ctg      696
 Met Leu Phe Leu Ala Glu Gln Pro Pro Leu Pro Pro Pro Pro Leu Leu
         175                 180                 185

 cct ccc agc ctc acc aat gga acc act atc ccc act gcc aag tcc acc      744
 Pro Pro Ser Leu Thr Asn Gly Thr Thr Ile Pro Thr Ala Lys Ser Thr
     190                 195                 200

 ccc aca ctc att aag caa agc caa ccc aag tct gcc agt gag aag tca      792
 Pro Thr Leu Ile Lys Gln Ser Gln Pro Lys Ser Ala Ser Glu Lys Ser
 205                 210                 215                 220

 cag cgc agc aag aag gcc aag gag ctg aag cca aag gtg aag aag ctc      840
 Gln Arg Ser Lys Lys Ala Lys Glu Leu Lys Pro Lys Val Lys Lys Leu
                 225                 230                 235

 aag tac cac cag tac atc ccc ccg gac cag aag cag gac agg ggg gca      888
 Lys Tyr His Gln Tyr Ile Pro Pro Asp Gln Lys Gln Asp Arg Gly Ala
             240                 245                 250

 ccc ccc atg gac tca tcc tac gcc aag atc ctg cag cag cag cag ctc      936
 Pro Pro Met Asp Ser Ser Tyr Ala Lys Ile Leu Gln Gln Gln Gln Leu
         255                 260                 265

 ttc ctc cag ctg cag atc ctc aac cag cag cag cag cag cac cac aac      984
 Phe Leu Gln Leu Gln Ile Leu Asn Gln Gln Gln Gln Gln His His Asn
     270                 275                 280

 tac cag gcc atc ctg cct gcc ccg cca aag tca gca ggc gag gcc ctg     1032
 Tyr Gln Ala Ile Leu Pro Ala Pro Pro Lys Ser Ala Gly Glu Ala Leu
 285                 290                 295                 300

 gga agc agc ggg acc ccc cca gta cgc agc ctc tcc act acc aat agc     1080
 Gly Ser Ser Gly Thr Pro Pro Val Arg Ser Leu Ser Thr Thr Asn Ser
                 305                 310                 315

 agc tcc agc tcg ggc gcc cct ggg ccc tgt ggg ctg gca cgt cag aac     1128
 Ser Ser Ser Ser Gly Ala Pro Gly Pro Cys Gly Leu Ala Arg Gln Asn
             320                 325                 330

 agc acc tca ctg act ggc aag ccg gga gcc ctg ccg gcc aac ctg gac     1176
 Ser Thr Ser Leu Thr Gly Lys Pro Gly Ala Leu Pro Ala Asn Leu Asp
         335                 340                 345

 gac atg aag gtg gca gag ctg aag cag gag ctg aag ttg cga tca ctg     1224
 Asp Met Lys Val Ala Glu Leu Lys Gln Glu Leu Lys Leu Arg Ser Leu
     350                 355                 360

 cct gtc tcg ggc acc aaa act gag ctg att gag cgc ctt cga gcc tat     1272
 Pro Val Ser Gly Thr Lys Thr Glu Leu Ile Glu Arg Leu Arg Ala Tyr
 365                 370                 375                 380

 caa gac caa atc agc cct gtg cca gga gcc ccc aag gcc cct gcc gcc     1320
 Gln Asp Gln Ile Ser Pro Val Pro Gly Ala Pro Lys Ala Pro Ala Ala
                 385                 390                 395

 acc tct atc ctg cac aag gct ggc gag gtg gtg gta gcc ttc cca gcg     1368
 Thr Ser Ile Leu His Lys Ala Gly Glu Val Val Val Ala Phe Pro Ala
             400                 405                 410

 gcc cgg ctg agc acg ggg cca gcc ctg gtg gca gca ggc ctg gct cca     1416
 Ala Arg Leu Ser Thr Gly Pro Ala Leu Val Ala Ala Gly Leu Ala Pro
         415                 420                 425

 gct gag gtg gtg gtg gcc acg gtg gcc agc agt ggg gtg gtg aag ttt     1464
 Ala Glu Val Val Val Ala Thr Val Ala Ser Ser Gly Val Val Lys Phe
     430                 435                 440

 ggc agc acg ggc tcc acg ccc ccc gtg tct ccc acc ccc tcg gag cgc     1512
 Gly Ser Thr Gly Ser Thr Pro Pro Val Ser Pro Thr Pro Ser Glu Arg
 445                 450                 455                 460

 tca ctg ctc agc acg ggc gat gaa aac tcc acc ccc ggg gac acc ttt     1560
 Ser Leu Leu Ser Thr Gly Asp Glu Asn Ser Thr Pro Gly Asp Thr Phe
                 465                 470                 475

 ggt gag atg gtg aca tca cct ctg acg cag ctg acc ctg cag gcc tcg     1608
 Gly Glu Met Val Thr Ser Pro Leu Thr Gln Leu Thr Leu Gln Ala Ser
             480                 485                 490

 cca ctg cag atc ctc gtg aag gag gag ggc ccc cgg gcc ggg tcc tgt     1656
 Pro Leu Gln Ile Leu Val Lys Glu Glu Gly Pro Arg Ala Gly Ser Cys
         495                 500                 505

 tgc ctg agc cct ggg ggg cgg gcg gag cta gag ggg cgc gac aag gac     1704
 Cys Leu Ser Pro Gly Gly Arg Ala Glu Leu Glu Gly Arg Asp Lys Asp
     510                 515                 520

 cag atg ctg cag gag aaa gac aag cag atc gag gcg ctg acg cgc atg     1752
 Gln Met Leu Gln Glu Lys Asp Lys Gln Ile Glu Ala Leu Thr Arg Met
 525                 530                 535                 540

 ctc cgg cag aag cag cag ctg gtg gag cgg ctc aag ctg cag ctg gag     1800
 Leu Arg Gln Lys Gln Gln Leu Val Glu Arg Leu Lys Leu Gln Leu Glu
                 545                 550                 555

 cag gag aag cga gcc cag cag ccc gcc ccc gcc ccc gcc ccc ctc ggc     1848
 Gln Glu Lys Arg Ala Gln Gln Pro Ala Pro Ala Pro Ala Pro Leu Gly
             560                 565                 570

 acc ccc gtg aag cag gag aac agc ttc tcc agc tgc cag ctg agc cag     1896
 Thr Pro Val Lys Gln Glu Asn Ser Phe Ser Ser Cys Gln Leu Ser Gln
         575                 580                 585

 cag ccc ctg ggc ccc gct cac cca ttc aac ccc agc ctg gcg gcc cca     1944
 Gln Pro Leu Gly Pro Ala His Pro Phe Asn Pro Ser Leu Ala Ala Pro
     590                 595                 600

 gcc acc aac cac ata gac cct tgt gct gtg gcc ccg ggg ccc ccg tcc     1992
 Ala Thr Asn His Ile Asp Pro Cys Ala Val Ala Pro Gly Pro Pro Ser
 605                 610                 615                 620

 gtg gtg gtg aag cag gaa gcc ttg cag cct gag ccc gag ccg gtc ccc     2040
 Val Val Val Lys Gln Glu Ala Leu Gln Pro Glu Pro Glu Pro Val Pro
                 625                 630                 635

 gcc ccc cag ttg ctt ctg ggg cct cag ggc ccc agc ctc atc aag ggg     2088
 Ala Pro Gln Leu Leu Leu Gly Pro Gln Gly Pro Ser Leu Ile Lys Gly
             640                 645                 650

 gtt gca cct ccc acc ctc atc acc gac tcc aca ggg acc cac ctt gtc     2136
 Val Ala Pro Pro Thr Leu Ile Thr Asp Ser Thr Gly Thr His Leu Val
         655                 660                 665

 ctc acc gtg acc aat aag aat gca gac agc cct ggc ctg tcc agt ggg     2184
 Leu Thr Val Thr Asn Lys Asn Ala Asp Ser Pro Gly Leu Ser Ser Gly
     670                 675                 680

 agc ccc cag gag atg gac ctg gag cac cca ctg cag ccc ctc ttt ggg     2232
 Ser Pro Gln Glu Met Asp Leu Glu His Pro Leu Gln Pro Leu Phe Gly
 685                 690                 695                 700

 acc ccc act tct ctg ctg aag aag gaa cca cct ggc tat gag gaa gcc     2280
 Thr Pro Thr Ser Leu Leu Lys Lys Glu Pro Pro Gly Tyr Glu Glu Ala
                 705                 710                 715

 atg agc cag cag ccc aaa cag cag gaa aat ggt tcc tca agc cag cag     2328
 Met Ser Gln Gln Pro Lys Gln Gln Glu Asn Gly Ser Ser Ser Gln Gln
             720                 725                 730

 atg gac gac ctg ttt gac att ctc att cag agc gga gaa att tca gca     2376
 Met Asp Asp Leu Phe Asp Ile Leu Ile Gln Ser Gly Glu Ile Ser Ala
         735                 740                 745

 gat ttc aag gag ccg cca tcc ctg cca ggg aag gag aag cca tcc ccg     2424
 Asp Phe Lys Glu Pro Pro Ser Leu Pro Gly Lys Glu Lys Pro Ser Pro
     750                 755                 760

 aag aca gtc tgt ggg tcc ccc ctg gca gca cag cca tca cct tct gct     2472
 Lys Thr Val Cys Gly Ser Pro Leu Ala Ala Gln Pro Ser Pro Ser Ala
 765                 770                 775                 780

 gag ctc ccc cag gct gcc cca cct cct cca ggc tca ccc tcc ctc cct     2520
 Glu Leu Pro Gln Ala Ala Pro Pro Pro Pro Gly Ser Pro Ser Leu Pro
                 785                 790                 795

 gga cgc ctg gag gac ttc ctg gag agc agc acg ggg ctg ccc ctg ctg     2568
 Gly Arg Leu Glu Asp Phe Leu Glu Ser Ser Thr Gly Leu Pro Leu Leu
             800                 805                 810

 acc agt ggg cat gac ggg cca gag ccc ctt tcc ctc att gac gac ctc     2616
 Thr Ser Gly His Asp Gly Pro Glu Pro Leu Ser Leu Ile Asp Asp Leu
         815                 820                 825

 cat agc cag atg ctg agc agc act gcc atc ctg gac cac ccc ccg tca     2664
 His Ser Gln Met Leu Ser Ser Thr Ala Ile Leu Asp His Pro Pro Ser
     830                 835                 840

 ccc atg gac acc tcg gaa ttg cac ttt gtt cct gag ccc agc agc acc     2712
 Pro Met Asp Thr Ser Glu Leu His Phe Val Pro Glu Pro Ser Ser Thr
 845                 850                 855                 860

 atg ggc ctg gac ctg gct gat ggc cac ctg gac agc atg gac tgg ctg     2760
 Met Gly Leu Asp Leu Ala Asp Gly His Leu Asp Ser Met Asp Trp Leu
                 865                 870                 875

 gag ctg tcg tca ggt ggt ccc gtg ctg agc cta gcc ccc ctc agc acc     2808
 Glu Leu Ser Ser Gly Gly Pro Val Leu Ser Leu Ala Pro Leu Ser Thr
             880                 885                 890

 aca gcc ccc agc ctc ttc tcc aca gac ttc ctc gat ggc cat gat ttg     2856
 Thr Ala Pro Ser Leu Phe Ser Thr Asp Phe Leu Asp Gly His Asp Leu
         895                 900                 905

 cag ctg cac tgg gat tcc tgc ttg tagctctctg gctcaagacg gggtggggaa    2910
 Gln Leu His Trp Asp Ser Cys Leu 
     910                 915

 ggggctggga gccagggtac tccaatgcgt ggctctcctg cgtgattcgg cctctccaca   2970

 tggttgtgag tcttgacaat cacagcccct gctttttccc ttccctggga ggctagaaca   3030

 gagaagccct tactcctggt tcagtgccac gcagggcaga ggagagcagc tgtcaagaag   3090

 cagccctggc tctcacgctg gggttttgga cacacggtca gggtcagggc catttcagct   3150

 tgacctcctt ttttgaggtc agggggcact gtctgtctgg ctacaatttg gctaaggtag   3210

 gtgaagcctg gccaggcggg aggctt                                        3236




      <210> 127
      <211> 537
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (242)..(472)

      <400> 127
 cttttgagcc ccgccccctc cattggcgcg ccctcgccat cccccgccct ggcacgcgct     60

 ctgcgcatgc gtacgctcgc tggccccgcc ccctagcgcc gcggtcgacg ccatttcgcc    120

 gattcctcca tgcgagttgc tgtgcgtttc tctgttgtct cggtagaagg ccagagtcac    180

 acacggtcct aagagctggg caccaggaag cgaaggctga tctgaagaag acacttgaat    240

 c    atg ggt gac gtt aaa aat ttt ctg tat gcc tgg tgt ggc aaa agg     286
      Met Gly Asp Val Lys Asn Phe Leu Tyr Ala Trp Cys Gly Lys Arg
        1               5                  10                  15

 aag atg acc cca tcc tat gaa att aga gca gtg ggg aac aaa aac agg      334
 Lys Met Thr Pro Ser Tyr Glu Ile Arg Ala Val Gly Asn Lys Asn Arg
                  20                  25                  30

 cag aaa ttc atg tgt gag gtt cag gtg gaa ggt tat aat tac act ggc      382
 Gln Lys Phe Met Cys Glu Val Gln Val Glu Gly Tyr Asn Tyr Thr Gly
              35                  40                  45

 atg gga aat tcc acc aat aaa aaa gat gca caa agc aat gct gcc aga      430
 Met Gly Asn Ser Thr Asn Lys Lys Asp Ala Gln Ser Asn Ala Ala Arg
          50                  55                  60

 gac ttt gtt aac tat tcg ggt cga ata aat gaa ata gac atg tgagaaa      479
 Asp Phe Val Asn Tyr Ser Gly Arg Ile Asn Glu Ile Asp Met 
      65                  70                  75

 gatcaccttt tggggaaccc tgttctgccg cgttactgtt actactggca gtagggca      537




      <210> 128
      <211> 1203
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (43)..(798)

      <400> 128
 gtccagtgcg gtggaattcc tctccgcatc aaagtcatct cc   atg ggc aac gcc      54
                                                  Met Gly Asn Ala
                                                    1

 gaa gtg ggg aaa agc tgt att ata aag cga tac tgt gag aaa aga ttc      102
 Glu Val Gly Lys Ser Cys Ile Ile Lys Arg Tyr Cys Glu Lys Arg Phe
   5                  10                  15                  20

 gtg tct aaa tac ctg gca aca att gga att gac tat gga gtc aca aag      150
 Val Ser Lys Tyr Leu Ala Thr Ile Gly Ile Asp Tyr Gly Val Thr Lys
                  25                  30                  35

 gta cac gtc aga gac aga gaa atc aaa gtt aac atc ttt gat atg gct      198
 Val His Val Arg Asp Arg Glu Ile Lys Val Asn Ile Phe Asp Met Ala
              40                  45                  50

 gga cat ccc ttc ttc tat gag gtt cga aat gag ttt tac aag gac aca      246
 Gly His Pro Phe Phe Tyr Glu Val Arg Asn Glu Phe Tyr Lys Asp Thr
          55                  60                  65

 cag ggt gtg ata ctg gtc tat gat gtt ggg cag aaa gac tcc ttt gac      294
 Gln Gly Val Ile Leu Val Tyr Asp Val Gly Gln Lys Asp Ser Phe Asp
      70                  75                  80

 gcc ctt gat gcg tgg ctg gca gaa atg aag caa gag ctt gga cct cat      342
 Ala Leu Asp Ala Trp Leu Ala Glu Met Lys Gln Glu Leu Gly Pro His
  85                  90                  95                 100

 gga aac atg gaa aat att ata ttt gta gtt tgt gcc aac aag att gat      390
 Gly Asn Met Glu Asn Ile Ile Phe Val Val Cys Ala Asn Lys Ile Asp
                 105                 110                 115

 tgt acc aaa cat cgc tgt gta gat gaa agt gaa gga cgt ctt tgg gct      438
 Cys Thr Lys His Arg Cys Val Asp Glu Ser Glu Gly Arg Leu Trp Ala
             120                 125                 130

 gaa agc aaa ggg ttc ctg tac ttt gaa act tca gca caa act gga gaa      486
 Glu Ser Lys Gly Phe Leu Tyr Phe Glu Thr Ser Ala Gln Thr Gly Glu
         135                 140                 145

 ggc att aat gag atg ttc cag acc ttt tat ata tcc ata gtt gat tta      534
 Gly Ile Asn Glu Met Phe Gln Thr Phe Tyr Ile Ser Ile Val Asp Leu
     150                 155                 160

 tgt gaa aat ggc ggg aaa cgc cct acc acc aat agc agt gct agt ttc      582
 Cys Glu Asn Gly Gly Lys Arg Pro Thr Thr Asn Ser Ser Ala Ser Phe
 165                 170                 175                 180

 acc aaa gaa caa gca gat gcc att cgc aga att cga aat agt aaa gac      630
 Thr Lys Glu Gln Ala Asp Ala Ile Arg Arg Ile Arg Asn Ser Lys Asp
                 185                 190                 195

 agt tgg gac atg ctg gga gtc aaa cct ggg gcc tca agg gat gaa gtc      678
 Ser Trp Asp Met Leu Gly Val Lys Pro Gly Ala Ser Arg Asp Glu Val
             200                 205                 210

 aat aaa gcg tat cgg aaa ctt gct gtg ctt ctt cac cct gac aaa tgt      726
 Asn Lys Ala Tyr Arg Lys Leu Ala Val Leu Leu His Pro Asp Lys Cys
         215                 220                 225

 gta gca cct ggc agt gaa gat gcc ttc aaa gca gtt gtg aat gct cgg      774
 Val Ala Pro Gly Ser Glu Asp Ala Phe Lys Ala Val Val Asn Ala Arg
     230                 235                 240

 aca gcc ctc ctg aaa aac atc aag tagaaagtac agaaaaaagc cacatgtggg     828
 Thr Ala Leu Leu Lys Asn Ile Lys 
 245                 250

 actcaaatgc aaacagactt tccctagagg tgaaataacc aacgtggagt tttccttccc    888

 agaatctcac tgctcttttc attcatgtgt tgtcatttgt atatcagtaa ttcaggtacc    948

 catttcatag acattttact gagaaatgac ctgcatttgt atgaagtgaa ctgagcgtca   1008

 caccctgtac ttcatttcat atttctagat aattctgaat ttttttctca ttcgtcagct   1068

 ctgtaattat agtatcactt agacatttca cttggggaaa tccacaaggt tcctggagga   1128

 gggaagagag gacaagagga ccctttcact ttttcttttt tacggaattc atcatcagag   1188

 aagaaaaaaa aaaaa                                                    1203




      <210> 129
      <211> 746
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (235)..(423)

      <400> 129
 gcacaggtct ggggcttttt gcaggcgggc ctggggtctc agtggagggg acaaaggcaa     60

 gcaaaagccc atgtccagga gccctgggtg tccccacagg ctcgcctctg agagcctctt    120

 tggggtgagc agccttgtat tggccacagg tgcactaaat tgactgtgaa tcccaaacct    180

 ccccagacca ggcaggccgc ctgcccccac ccagaacctt ccggtttgcc ctgt  atg     237
                                                              Met
                                                                1

 gaa agc cac tct cgg aaa tcc ctc ttt cct gag tca gca atc gtg gca      285
 Glu Ser His Ser Arg Lys Ser Leu Phe Pro Glu Ser Ala Ile Val Ala
               5                  10                  15

 agg gga cat gtg ttc caa cag cgg ctg ggg agt gga cct ctc tgt ccc      333
 Arg Gly His Val Phe Gln Gln Arg Leu Gly Ser Gly Pro Leu Cys Pro
          20                  25                  30

 ttg ccc acc tta agc ccc aaa tcc gga ccc cct ctg aca tca ctg gca      381
 Leu Pro Thr Leu Ser Pro Lys Ser Gly Pro Pro Leu Thr Ser Leu Ala
      35                  40                  45

 ttg cac ctg ggt gtg ccc ccc tcc cca cgc tat gga ccc aga taggagg      430
 Leu His Leu Gly Val Pro Pro Ser Pro Arg Tyr Gly Pro Arg 
  50                  55                  60

 ggttaggcat gggggaggca cagaatgctg gagagatgcg tcctggtgaa cgtggggcag    490

 cccctcccac gacccccacc agactgcctt aggttttgtc agccccactc cctttccttc    550

 ccctctgcct cccacccact ctgggggtcc acatcaagat agctgggccc agtgtggaag    610

 cccaacgtgt ctgttctagc agaaaggaca caagcctggt gttctggaga cctcggctca    670

 agtctttgcc ctgctgccga cgcattgtgt caccttgggc aaggatttcg catctccagg    730

 cctcagtttc cccatt                                                    746




      <210> 130
      <211> 4895
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4782)

      <400> 130
  atg ggg ttt cac cat gtt ggc cac gct ggt ctc gaa cac ctg acc tca      48
  Met Gly Phe His His Val Gly His Ala Gly Leu Glu His Leu Thr Ser
    1               5                  10                  15

 ggt gac agg ctg gga agg aga tcc tca agc aag cgg gct ctc aaa gcc       96
 Gly Asp Arg Leu Gly Arg Arg Ser Ser Ser Lys Arg Ala Leu Lys Ala
              20                  25                  30

 gag ggg acc cca ggc agg cgc gga gct cag cga agc cag aag gag cgc      144
 Glu Gly Thr Pro Gly Arg Arg Gly Ala Gln Arg Ser Gln Lys Glu Arg
          35                  40                  45

 gcc ggg ggc agc cca agc ccg ggg tct ccc cgg agg aag caa aca ggg      192
 Ala Gly Gly Ser Pro Ser Pro Gly Ser Pro Arg Arg Lys Gln Thr Gly
      50                  55                  60

 cgc agg aga cac aga gaa gag ctg ggg gag cag gag cgg ggc gag gca      240
 Arg Arg Arg His Arg Glu Glu Leu Gly Glu Gln Glu Arg Gly Glu Ala
  65                  70                  75                  80

 gag agg acc tgc gag ggc agg aga aag cgc gac gag agg gcc tcc ttc      288
 Glu Arg Thr Cys Glu Gly Arg Arg Lys Arg Asp Glu Arg Ala Ser Phe
                  85                  90                  95

 cag gag cgg aca gca gcc cca aag agg gaa aag gag att ccg agg agg      336
 Gln Glu Arg Thr Ala Ala Pro Lys Arg Glu Lys Glu Ile Pro Arg Arg
             100                 105                 110

 gag gag aag tcg aag cgg cag aag aaa ccc agg tca tcc tcc ttg gcc      384
 Glu Glu Lys Ser Lys Arg Gln Lys Lys Pro Arg Ser Ser Ser Leu Ala
         115                 120                 125

 tcc agt gcc tct ggt ggg gag tcc ctg tcc gag gag gaa ctg gcc cgg      432
 Ser Ser Ala Ser Gly Gly Glu Ser Leu Ser Glu Glu Glu Leu Ala Arg
     130                 135                 140

 atc ctg gag cag gtg gaa gaa aaa aag aag ctc att gcc acc atg cgg      480
 Ile Leu Glu Gln Val Glu Glu Lys Lys Lys Leu Ile Ala Thr Met Arg
 145                 150                 155                 160

 agc aag ccc tgg ccc atg gcg aag aag ctg aca gag ctc agg gag gcc      528
 Ser Lys Pro Trp Pro Met Ala Lys Lys Leu Thr Glu Leu Arg Glu Ala
                 165                 170                 175

 cag gaa ttt gtg gag aag tat gaa ggt gcc ttg gga aag ggg aaa ggc      576
 Gln Glu Phe Val Glu Lys Tyr Glu Gly Ala Leu Gly Lys Gly Lys Gly
             180                 185                 190

 aag caa cta tat gcc tac aag atg ctg atg gcc aag aaa tgg gtc aaa      624
 Lys Gln Leu Tyr Ala Tyr Lys Met Leu Met Ala Lys Lys Trp Val Lys
         195                 200                 205

 ttt aag aga gac ttt gat aat ttc aag act caa tgt atc ccc tgg gaa      672
 Phe Lys Arg Asp Phe Asp Asn Phe Lys Thr Gln Cys Ile Pro Trp Glu
     210                 215                 220

 atg aag atc aag gac att gaa agt cac ttt ggt tct tca gtg gca tcg      720
 Met Lys Ile Lys Asp Ile Glu Ser His Phe Gly Ser Ser Val Ala Ser
 225                 230                 235                 240

 tat ttc atc ttt ctc cga tgg atg tat gga gtt aac ctt gtc ctt ttt      768
 Tyr Phe Ile Phe Leu Arg Trp Met Tyr Gly Val Asn Leu Val Leu Phe
                 245                 250                 255

 ggc tta ata ttt ggt cta gtc ata atc cca gag gat gtc tac gtg atc      816
 Gly Leu Ile Phe Gly Leu Val Ile Ile Pro Glu Asp Val Tyr Val Ile
             260                 265                 270

 cct gag gaa ccc tca gtt atg ctg cag gag ctg gct ggc aag gcc cca      864
 Pro Glu Glu Pro Ser Val Met Leu Gln Glu Leu Ala Gly Lys Ala Pro
         275                 280                 285

 ctg gat gac aag ttt atg tac ttc tct tcc aac act gga tcc tac ggt      912
 Leu Asp Asp Lys Phe Met Tyr Phe Ser Ser Asn Thr Gly Ser Tyr Gly
     290                 295                 300

 cta ggt ttt gac caa ggc tac aat tat ctt gag gct gaa ctg aag aag      960
 Leu Gly Phe Asp Gln Gly Tyr Asn Tyr Leu Glu Ala Glu Leu Lys Lys
 305                 310                 315                 320

 atc cgc ttc caa gct cac tca cat ggc tac tgg cag atc tca gaa gat     1008
 Ile Arg Phe Gln Ala His Ser His Gly Tyr Trp Gln Ile Ser Glu Asp
                 325                 330                 335

 aca att tca agc tta ctc acg tgg ctt ctg gca ggc ctc aga aaa tct     1056
 Thr Ile Ser Ser Leu Leu Thr Trp Leu Leu Ala Gly Leu Arg Lys Ser
             340                 345                 350

 gct tcc aac ctt act tat gtg gct gtt ccc aag gtt cag ggc tat atc     1104
 Ala Ser Asn Leu Thr Tyr Val Ala Val Pro Lys Val Gln Gly Tyr Ile
         355                 360                 365

 aag tac tct gca ctc ttc tat ggc tac tac aac aac cag agg acc atc     1152
 Lys Tyr Ser Ala Leu Phe Tyr Gly Tyr Tyr Asn Asn Gln Arg Thr Ile
     370                 375                 380

 ggg tgg ctg agg tac cgg ctg cct atg gct tac ttt atg gtg ggg gtc     1200
 Gly Trp Leu Arg Tyr Arg Leu Pro Met Ala Tyr Phe Met Val Gly Val
 385                 390                 395                 400

 agc gtg ttc ggc tac agc ctg att att gtc att cga tcg atg gcc agc     1248
 Ser Val Phe Gly Tyr Ser Leu Ile Ile Val Ile Arg Ser Met Ala Ser
                 405                 410                 415

 aat acc caa gga agc aca ggc gaa ggg gag agt gac aac ttc aca ttc     1296
 Asn Thr Gln Gly Ser Thr Gly Glu Gly Glu Ser Asp Asn Phe Thr Phe
             420                 425                 430

 agc ttc aag atg ttc acc agc tgg gac tac ctg atc ggg aat tca gag     1344
 Ser Phe Lys Met Phe Thr Ser Trp Asp Tyr Leu Ile Gly Asn Ser Glu
         435                 440                 445

 aca gct gat aac aaa tat gca tcc atc acc acc agc ttc aag gaa tca     1392
 Thr Ala Asp Asn Lys Tyr Ala Ser Ile Thr Thr Ser Phe Lys Glu Ser
     450                 455                 460

 ata gtg gat gaa caa gag agt aac aaa gaa gaa aat atc cat ctg aca     1440
 Ile Val Asp Glu Gln Glu Ser Asn Lys Glu Glu Asn Ile His Leu Thr
 465                 470                 475                 480

 aga ttt ctt cgt gtc ctg gcc aac ttt ctc atc atc tgc tgt ttg tgt     1488
 Arg Phe Leu Arg Val Leu Ala Asn Phe Leu Ile Ile Cys Cys Leu Cys
                 485                 490                 495

 gga agt ggg tac ctc att tac ttt gtg gtt aag cga tct cag caa ttc     1536
 Gly Ser Gly Tyr Leu Ile Tyr Phe Val Val Lys Arg Ser Gln Gln Phe
             500                 505                 510

 tcc aaa atg cag aat gtc agc tgg tat gaa agg aat gag gta gag atc     1584
 Ser Lys Met Gln Asn Val Ser Trp Tyr Glu Arg Asn Glu Val Glu Ile
         515                 520                 525

 gtg atg tcc ctg ctt gga atg ttt tgt ccc cct ctg ttt gaa acc atc     1632
 Val Met Ser Leu Leu Gly Met Phe Cys Pro Pro Leu Phe Glu Thr Ile
     530                 535                 540

 gct gcc ctg gag aat tac cac cca cgc act gga ctg aag tgg cag ctg     1680
 Ala Ala Leu Glu Asn Tyr His Pro Arg Thr Gly Leu Lys Trp Gln Leu
 545                 550                 555                 560

 gga cgc atc ttt gca ctc ttc ctg ggg aac ctc tac aca ttt ctc ttg     1728
 Gly Arg Ile Phe Ala Leu Phe Leu Gly Asn Leu Tyr Thr Phe Leu Leu
                 565                 570                 575

 gcc ctg atg gat gat gtc cac ctc aag ctt gct aat gaa gag aca ata     1776
 Ala Leu Met Asp Asp Val His Leu Lys Leu Ala Asn Glu Glu Thr Ile
             580                 585                 590

 aag aac atc act cac tgg act ctg ttt aac tat tac aac tct tct ggt     1824
 Lys Asn Ile Thr His Trp Thr Leu Phe Asn Tyr Tyr Asn Ser Ser Gly
         595                 600                 605

 tgg aac gag agt gtc ccc cga cca ccc ctg cac cct gca gat gtg ccc     1872
 Trp Asn Glu Ser Val Pro Arg Pro Pro Leu His Pro Ala Asp Val Pro
     610                 615                 620

 cgg ggt tct tgc tgg gag aca gct gtg ggc att gaa ttc atg agg ctg     1920
 Arg Gly Ser Cys Trp Glu Thr Ala Val Gly Ile Glu Phe Met Arg Leu
 625                 630                 635                 640

 acg gtg tct gac atg ctg gta acg tac atc acc atc ctg ctg ggg gac     1968
 Thr Val Ser Asp Met Leu Val Thr Tyr Ile Thr Ile Leu Leu Gly Asp
                 645                 650                 655

 ttc cta cgg gct tgt ttt gtg cgg ttc atg aac tac tgc tgg tgc tgg     2016
 Phe Leu Arg Ala Cys Phe Val Arg Phe Met Asn Tyr Cys Trp Cys Trp
             660                 665                 670

 gac ttg gag gct gga ttt cct tca tat gct gag ttt gat att agt gga     2064
 Asp Leu Glu Ala Gly Phe Pro Ser Tyr Ala Glu Phe Asp Ile Ser Gly
         675                 680                 685

 aat gtg ctg ggt ttg atc ttc aac caa gga atg atc tgg atg ggc tcc     2112
 Asn Val Leu Gly Leu Ile Phe Asn Gln Gly Met Ile Trp Met Gly Ser
     690                 695                 700

 ttc tat gct cca ggc ctg gtg ggc att aat gtg ctg cgc ctg ctg acc     2160
 Phe Tyr Ala Pro Gly Leu Val Gly Ile Asn Val Leu Arg Leu Leu Thr
 705                 710                 715                 720

 tcc atg tac ttc cag tgc tgg gcg gtg atg agc agc aac gta ccc cat     2208
 Ser Met Tyr Phe Gln Cys Trp Ala Val Met Ser Ser Asn Val Pro His
                 725                 730                 735

 gaa cgc gtg ttc aaa gcc tcc cga tcc aac aac ttc tac atg ggc ctc     2256
 Glu Arg Val Phe Lys Ala Ser Arg Ser Asn Asn Phe Tyr Met Gly Leu
             740                 745                 750

 ctg ctg ctg gtg ctc ttc ctc agc ctc ctg ccg gtg gcc tac acc atc     2304
 Leu Leu Leu Val Leu Phe Leu Ser Leu Leu Pro Val Ala Tyr Thr Ile
         755                 760                 765

 atg tcc ctc cca ccc tcc ttt gac tgc ggg ccg ttc agt ggg aaa aac     2352
 Met Ser Leu Pro Pro Ser Phe Asp Cys Gly Pro Phe Ser Gly Lys Asn
     770                 775                 780

 aga atg tac gat gtc ctc caa gag acc att gaa aac gat ttc cca acc     2400
 Arg Met Tyr Asp Val Leu Gln Glu Thr Ile Glu Asn Asp Phe Pro Thr
 785                 790                 795                 800

 ttc ctg ggc aag atc ttt gct ttc ctc gcc aat cca ggc ctg atc atc     2448
 Phe Leu Gly Lys Ile Phe Ala Phe Leu Ala Asn Pro Gly Leu Ile Ile
                 805                 810                 815

 cca gcc atc ctg ctg atg ttc ttg gcc att tac tac ctg aac tca gtt     2496
 Pro Ala Ile Leu Leu Met Phe Leu Ala Ile Tyr Tyr Leu Asn Ser Val
             820                 825                 830

 tcc aaa agc ctt tcc cga gct aat gcc cag ctg agg aag aaa atc caa     2544
 Ser Lys Ser Leu Ser Arg Ala Asn Ala Gln Leu Arg Lys Lys Ile Gln
         835                 840                 845

 gtg ctc cgt gaa gtt gag aag agc cac aaa tct gta aaa ggc aaa gcc     2592
 Val Leu Arg Glu Val Glu Lys Ser His Lys Ser Val Lys Gly Lys Ala
     850                 855                 860

 aca gcc aga gat tca gag gac aca cct aaa agc agc tcc aaa aat gcc     2640
 Thr Ala Arg Asp Ser Glu Asp Thr Pro Lys Ser Ser Ser Lys Asn Ala
 865                 870                 875                 880

 acc cag ctc caa ctc acc aag gaa gag acc act cct ccc tct gcc agc     2688
 Thr Gln Leu Gln Leu Thr Lys Glu Glu Thr Thr Pro Pro Ser Ala Ser
                 885                 890                 895

 caa agc cag gcc atg gac aag aag gcg cag ggc cct ggg acc tcc aat     2736
 Gln Ser Gln Ala Met Asp Lys Lys Ala Gln Gly Pro Gly Thr Ser Asn
             900                 905                 910

 tct gcc agc agg acc aca ctg cct gcc tct gga cac ctt cct ata tct     2784
 Ser Ala Ser Arg Thr Thr Leu Pro Ala Ser Gly His Leu Pro Ile Ser
         915                 920                 925

 cgg ccc cct gga atc gga cca gat tct ggc cac gcc cca tct cag act     2832
 Arg Pro Pro Gly Ile Gly Pro Asp Ser Gly His Ala Pro Ser Gln Thr
     930                 935                 940

 cat ccg tgg aga cag agc ctg ggc ctg ggc ctg ggc ctg ggc ctg ggc     2880
 His Pro Trp Arg Gln Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Gly
 945                 950                 955                 960

 ctg ggc ctg cgc ctg cgc ctg ccc tgg gaa cgg gtt ccg gca gac gct     2928
 Leu Gly Leu Arg Leu Arg Leu Pro Trp Glu Arg Val Pro Ala Asp Ala
                 965                 970                 975

 gag gtt gcg ttg acg ctc gcg ccc cgg ctc ccg ttc cag gtg ctg ttg     2976
 Glu Val Ala Leu Thr Leu Ala Pro Arg Leu Pro Phe Gln Val Leu Leu
             980                 985                 990

 cac gtg ctg ttt gag cac gcg gtc ggc tac gcg ctg ctg gcg ctg aag     3024
 His Val Leu Phe Glu His Ala Val Gly Tyr Ala Leu Leu Ala Leu Lys
         995                1000                1005

 gaa gtg gag gag atc agt ctg ctg cag ccc gca gca tgc aca gcg cgc     3072
 Glu Val Glu Glu Ile Ser Leu Leu Gln Pro Ala Ala Cys Thr Ala Arg
    1010                1015                1020

 tcc cac gtg gcc ggc cga ccg gtg gag gag tcc gtg ctc aac ctg ggc     3120
 Ser His Val Ala Gly Arg Pro Val Glu Glu Ser Val Leu Asn Leu Gly
1025                1030                1035                1040

 aaa ttc cac agc atc gtt cgt ctg gtg gcc ttt tgt ccc ttt gcc tca     3168
 Lys Phe His Ser Ile Val Arg Leu Val Ala Phe Cys Pro Phe Ala Ser
                1045                1050                1055

 tcc cag gtt gcc ttg gaa aat gcc aac gcc gtg tct gaa ggg gtt gtt     3216
 Ser Gln Val Ala Leu Glu Asn Ala Asn Ala Val Ser Glu Gly Val Val
            1060                1065                1070

 cat gag gac ctc cgc ctg ctc ttg gag acc cac ctg ccg tcc aaa aag     3264
 His Glu Asp Leu Arg Leu Leu Leu Glu Thr His Leu Pro Ser Lys Lys
        1075                1080                1085

 aag aaa gta ctc ttg gga gtt ggg gat ccc aag att ggt gcc gca ata     3312
 Lys Lys Val Leu Leu Gly Val Gly Asp Pro Lys Ile Gly Ala Ala Ile
    1090                1095                1100

 cag gag gag tta ggg tac aac tgc cag act gga gga gtc ata gct gag     3360
 Gln Glu Glu Leu Gly Tyr Asn Cys Gln Thr Gly Gly Val Ile Ala Glu
1105                1110                1115                1120

 atc ctg cga gga gtt cgt ctg cac ttc cac aat ctg gtg aag ggt ctg     3408
 Ile Leu Arg Gly Val Arg Leu His Phe His Asn Leu Val Lys Gly Leu
                1125                1130                1135

 acc gat ctg tca gct tgt aaa gca cag ctg ggg ctg gga cac agc tat     3456
 Thr Asp Leu Ser Ala Cys Lys Ala Gln Leu Gly Leu Gly His Ser Tyr
            1140                1145                1150

 tcc cgt gcc aaa gtt aag ttt aat gtg aac cgg gtg gac aat atg atc     3504
 Ser Arg Ala Lys Val Lys Phe Asn Val Asn Arg Val Asp Asn Met Ile
        1155                1160                1165

 atc cag tcc att agc ctc ctg gac cag ctg gat aag gac atc aat acc     3552
 Ile Gln Ser Ile Ser Leu Leu Asp Gln Leu Asp Lys Asp Ile Asn Thr
    1170                1175                1180

 ttc tct atg cgt gtc agg gag tgg tac ggg tat cac ttt ccg gag ctg     3600
 Phe Ser Met Arg Val Arg Glu Trp Tyr Gly Tyr His Phe Pro Glu Leu
1185                1190                1195                1200

 gtg aag atc atc aac gac aat gcc aca tac tgc cgt ctt gcc cag ttt     3648
 Val Lys Ile Ile Asn Asp Asn Ala Thr Tyr Cys Arg Leu Ala Gln Phe
                1205                1210                1215

 att gga aac cga agg gaa ctg aat gag gac aag ctg gag aag ctg gag     3696
 Ile Gly Asn Arg Arg Glu Leu Asn Glu Asp Lys Leu Glu Lys Leu Glu
            1220                1225                1230

 gag ctg aca atg gat ggg gcc aag gct aag gct att ctg gat gcc tca     3744
 Glu Leu Thr Met Asp Gly Ala Lys Ala Lys Ala Ile Leu Asp Ala Ser
        1235                1240                1245

 cgg tcc tcc atg ggc atg gac ata tct gcc att gac ttg ata aac atc     3792
 Arg Ser Ser Met Gly Met Asp Ile Ser Ala Ile Asp Leu Ile Asn Ile
    1250                1255                1260

 gag agc ttc tcc agt cgt gtg gtg tct tta tct gaa tac cgc cag agc     3840
 Glu Ser Phe Ser Ser Arg Val Val Ser Leu Ser Glu Tyr Arg Gln Ser
1265                1270                1275                1280

 cta cac act tac ctg cgc tcc aag atg agc caa gta gcc ccc agc ctg     3888
 Leu His Thr Tyr Leu Arg Ser Lys Met Ser Gln Val Ala Pro Ser Leu
                1285                1290                1295

 tca gcc cta att ggg gaa gcg gta ggt gca cgt ctc atc gca cat gct     3936
 Ser Ala Leu Ile Gly Glu Ala Val Gly Ala Arg Leu Ile Ala His Ala
            1300                1305                1310

 ggc agc ctc acc aac ctg gcc aag tat cca gca tcc aca gtg cag atc     3984
 Gly Ser Leu Thr Asn Leu Ala Lys Tyr Pro Ala Ser Thr Val Gln Ile
        1315                1320                1325

 ctt ggg gct gaa aag gcc ctg ttc aga gcc ctg aag aca agg ggt aac     4032
 Leu Gly Ala Glu Lys Ala Leu Phe Arg Ala Leu Lys Thr Arg Gly Asn
    1330                1335                1340

 acc cca aaa tat gga ctc att ttc cac tcc acc ttc att ggc cga gca     4080
 Thr Pro Lys Tyr Gly Leu Ile Phe His Ser Thr Phe Ile Gly Arg Ala
1345                1350                1355                1360

 gct gcc aag aac aaa ggc cgc atc tcc cga tac ctg gca aac aaa tgc     4128
 Ala Ala Lys Asn Lys Gly Arg Ile Ser Arg Tyr Leu Ala Asn Lys Cys
                1365                1370                1375

 agt att gcc tca cga atc gat tgc ttc tct gag gtg ccc acg agt gta     4176
 Ser Ile Ala Ser Arg Ile Asp Cys Phe Ser Glu Val Pro Thr Ser Val
            1380                1385                1390

 ttc ggg gag aag ctt cga gaa caa gtt gaa gag cga ctg tcc ttc tat     4224
 Phe Gly Glu Lys Leu Arg Glu Gln Val Glu Glu Arg Leu Ser Phe Tyr
        1395                1400                1405

 gag act gga gag ata cca cga aag aat ctg gat gtc atg aag gaa gca     4272
 Glu Thr Gly Glu Ile Pro Arg Lys Asn Leu Asp Val Met Lys Glu Ala
    1410                1415                1420

 atg gtt cag gca gag gaa gca gct gct gag att act agg aag ctg gag     4320
 Met Val Gln Ala Glu Glu Ala Ala Ala Glu Ile Thr Arg Lys Leu Glu
1425                1430                1435                1440

 aaa cag gag aag aaa cgc tta aag aag gaa aag aaa cgg ctg gct gca     4368
 Lys Gln Glu Lys Lys Arg Leu Lys Lys Glu Lys Lys Arg Leu Ala Ala
                1445                1450                1455

 ctt gcc ctc gcg tct tca gaa aac agc agt agt act cca gag gag tgt     4416
 Leu Ala Leu Ala Ser Ser Glu Asn Ser Ser Ser Thr Pro Glu Glu Cys
            1460                1465                1470

 gag gag atg agt gaa aaa ccc aaa aag aag aaa aag caa aag ccc cag     4464
 Glu Glu Met Ser Glu Lys Pro Lys Lys Lys Lys Lys Gln Lys Pro Gln
        1475                1480                1485

 gag gtt cct cag gag aat gga atg gaa gac cca tct atc tct ttc tcc     4512
 Glu Val Pro Gln Glu Asn Gly Met Glu Asp Pro Ser Ile Ser Phe Ser
    1490                1495                1500

 aaa ccc aag aaa aag aaa tct ttt tcc aag gag gag ttg atg agt agc     4560
 Lys Pro Lys Lys Lys Lys Ser Phe Ser Lys Glu Glu Leu Met Ser Ser
1505                1510                1515                1520

 gat ctt gaa gag acc gct ggc agc acc agt att ccc aag agg aag aag     4608
 Asp Leu Glu Glu Thr Ala Gly Ser Thr Ser Ile Pro Lys Arg Lys Lys
                1525                1530                1535

 tct aca ccc aag gag gaa aca gtt aat gac cct gag gag gca ggc cac     4656
 Ser Thr Pro Lys Glu Glu Thr Val Asn Asp Pro Glu Glu Ala Gly His
            1540                1545                1550

 aga agt ggc tcc aag aaa aag agg aaa ttc tcc aaa gag gag ccg gtc     4704
 Arg Ser Gly Ser Lys Lys Lys Arg Lys Phe Ser Lys Glu Glu Pro Val
        1555                1560                1565

 agc agt ggg cct gaa gag gcg gct ggc aag agc agc tcc aag aag aag     4752
 Ser Ser Gly Pro Glu Glu Ala Ala Gly Lys Ser Ser Ser Lys Lys Lys
    1570                1575                1580

 aaa aag ttc cat aaa gca tcc cag gaa gat t agaatgcaaa tggacattct     4803
 Lys Lys Phe His Lys Ala Ser Gln Glu Asp 
1585                1590

 ctgggaggtg gggcatacca tagcccaagg tgacatttcc caccctgtgc cgtgttcccc   4863

 aataaaaaca aattcacaag aaaaaaaaaa aa                                 4895




      <210> 131
      <211> 2338
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (406)..(1686)

      <400> 131
 gacaccgggg aggcagtgta tcgctcccgg gaccccgtgc gcaacttgcg cctccgagtc     60

 cacctgcaaa gaatcacatc aagcaacttt cttcattatc agcctgctgc cgagctcggg    120

 aaggacctca tagacttggc cacttttagg cctcagccaa ctgccagtgg acaccgccca    180

 gaggaagacg aagaggagga gattgtgatt gggtggcagg agaagctctt tagccagttt    240

 gaagtagatc tgtaccaaaa tgaaacagcc tgtcagagtc ctttggatta tcagtaccgt    300

 caggagatcc tgaagctgga gaattcgggt ggcaagaaaa accgacgaat ctttacctac    360

 actgactctg atagatacac caatttggag gagcactgtc agaga    atg acc act     414
                                                      Met Thr Thr
                                                        1

 gca gcc agc gag gtg cct tca ttc ttg gtc gag cga atg gca aat gtc      462
 Ala Ala Ser Glu Val Pro Ser Phe Leu Val Glu Arg Met Ala Asn Val
       5                  10                  15

 agg cgt cgc cgg cag gac agg cga ggg atg gag ggc ggc atc ctc aag      510
 Arg Arg Arg Arg Gln Asp Arg Arg Gly Met Glu Gly Gly Ile Leu Lys
  20                  25                  30                  35

 tca cgc atc gtc acc tgg gag ccc tca gaa gag ttt gtc agg aac aac      558
 Ser Arg Ile Val Thr Trp Glu Pro Ser Glu Glu Phe Val Arg Asn Asn
                  40                  45                  50

 cac gtc att aac acc cct ctt cag aca atg cac atc atg gca gac ctg      606
 His Val Ile Asn Thr Pro Leu Gln Thr Met His Ile Met Ala Asp Leu
              55                  60                  65

 ggg ccc tat aaa aag ctt ggc tat aag aag tat gaa cat gtc ctg tgt      654
 Gly Pro Tyr Lys Lys Leu Gly Tyr Lys Lys Tyr Glu His Val Leu Cys
          70                  75                  80

 act ctg aag gtg gat agc aat ggt gtg atc aca gta aag cct gac ttc      702
 Thr Leu Lys Val Asp Ser Asn Gly Val Ile Thr Val Lys Pro Asp Phe
      85                  90                  95

 acg ggc ctc aaa gga ccc tac agg att gag acg gag ggg gag aag cag      750
 Thr Gly Leu Lys Gly Pro Tyr Arg Ile Glu Thr Glu Gly Glu Lys Gln
 100                 105                 110                 115

 gag ctg tgg aaa tat acg atc gac aat gtt tcc ccc cac gca cag ccg      798
 Glu Leu Trp Lys Tyr Thr Ile Asp Asn Val Ser Pro His Ala Gln Pro
                 120                 125                 130

 gag gag gag gag cgg gaa cgg cga gtg ttc aag gat ctt tat ggc cgg      846
 Glu Glu Glu Glu Arg Glu Arg Arg Val Phe Lys Asp Leu Tyr Gly Arg
             135                 140                 145

 cac aag gag tat ctc agc agc ctc gta ggc acc gac ttt gag atg act      894
 His Lys Glu Tyr Leu Ser Ser Leu Val Gly Thr Asp Phe Glu Met Thr
         150                 155                 160

 gtc cca ggt gcc ctc cgg ctc ttt gta aat gga gag gtc gtt tca gcc      942
 Val Pro Gly Ala Leu Arg Leu Phe Val Asn Gly Glu Val Val Ser Ala
     165                 170                 175

 caa ggc tat gag tat gac aat ctc tac gtc cac ttc ttt gta gaa ttg      990
 Gln Gly Tyr Glu Tyr Asp Asn Leu Tyr Val His Phe Phe Val Glu Leu
 180                 185                 190                 195

 cca act gct cgc gag ctt act ata ttt ggt ctt tgg ctt tca gac tgg     1038
 Pro Thr Ala Arg Glu Leu Thr Ile Phe Gly Leu Trp Leu Ser Asp Trp
                 200                 205                 210

 tca agc cca gca ttc cag cag ctc tca gga gta aca cag acc tgc acc     1086
 Ser Ser Pro Ala Phe Gln Gln Leu Ser Gly Val Thr Gln Thr Cys Thr
             215                 220                 225

 acc aag tcc ctg gca atg gac aag gtg gct cac ttc tcc tac cca ttc     1134
 Thr Lys Ser Leu Ala Met Asp Lys Val Ala His Phe Ser Tyr Pro Phe
         230                 235                 240

 acg ttt gaa gcc ttc ttc ctc cat gag gat gaa tct tct gat gca ctc     1182
 Thr Phe Glu Ala Phe Phe Leu His Glu Asp Glu Ser Ser Asp Ala Leu
     245                 250                 255

 ccg gag tgg cct gtg ctc tac tgt gag gtc ctc tcg ctg gac ttc tgg     1230
 Pro Glu Trp Pro Val Leu Tyr Cys Glu Val Leu Ser Leu Asp Phe Trp
 260                 265                 270                 275

 cag agg tac cgt gtg gaa ggc tat ggg gct gtg gtg ctg cct gcc act     1278
 Gln Arg Tyr Arg Val Glu Gly Tyr Gly Ala Val Val Leu Pro Ala Thr
                 280                 285                 290

 cca ggc tca cac acc ctg aca gtc tcc acg tgg aga cct gtg gag ctt     1326
 Pro Gly Ser His Thr Leu Thr Val Ser Thr Trp Arg Pro Val Glu Leu
             295                 300                 305

 ggc acg gtg gct gag ctg agg agg ttt ttc att ggc ggt tct ctg gaa     1374
 Gly Thr Val Ala Glu Leu Arg Arg Phe Phe Ile Gly Gly Ser Leu Glu
         310                 315                 320

 ctg gag gac ctc tcc tat gta cgg ata cca gga tcc ttc aag ggg gaa     1422
 Leu Glu Asp Leu Ser Tyr Val Arg Ile Pro Gly Ser Phe Lys Gly Glu
     325                 330                 335

 cgc ctg agc cgc ttt gga ctc cgc aca gag acc aca ggc act gtc acc     1470
 Arg Leu Ser Arg Phe Gly Leu Arg Thr Glu Thr Thr Gly Thr Val Thr
 340                 345                 350                 355

 ttc cgc ttg cac tgt ctg cag cag tcc agg gcc ttc atg gaa tcg agc     1518
 Phe Arg Leu His Cys Leu Gln Gln Ser Arg Ala Phe Met Glu Ser Ser
                 360                 365                 370

 tcc ctt cag aaa agg atg cgg agt gtg ttg gac cgt ctg gaa ggg ttc     1566
 Ser Leu Gln Lys Arg Met Arg Ser Val Leu Asp Arg Leu Glu Gly Phe
             375                 380                 385

 agc cag cag agt tcc att cac aat gtg cta gag gcc ttc cgt cga gcc     1614
 Ser Gln Gln Ser Ser Ile His Asn Val Leu Glu Ala Phe Arg Arg Ala
         390                 395                 400

 cgg cgc cgc atg cag gag gcc cgg gaa agc ctc ccg cag gac cta gtg     1662
 Arg Arg Arg Met Gln Glu Ala Arg Glu Ser Leu Pro Gln Asp Leu Val
     405                 410                 415

 agc ccc tct gga acc ctg gtc tcc tagctcacag cagccctggc ccacagtgca    1716
 Ser Pro Ser Gly Thr Leu Val Ser 
 420                 425

 agaggacaag atgggggata tctgaggcca gtgctctcct gcctcttcgt ctttctgatt   1776

 agagaccacg ttggtctgct gagaaccaga aaagctggga aattcccggc tggcccctct   1836

 gcctagcctt ctgcagggtc ttctccctac cctgtggaaa taaagccaga gaccctgtgg   1896

 cccccccttt atatttgcag ccactgtcaa tgggcatcac agcaaggcag gctttttgat   1956

 ctgaagctgt ttggggtgac cccatagtga gtctggcctt gactcacttt tctggcttgt   2016

 ctcacagtag caggggatct gctgttctcc accctttaaa aatggagcct ttcatcttcc   2076

 aagaccaaag aaggaaggaa ggtggacggt gagagggtct taaatcccca gcctgtgagt   2136

 ctcagcctct ttccagggaa gcctcattct actgcttggg gcttgctgag gttgagatat   2196

 gagttatttc tgagtaagtg aaggctgaag gcagtgctga gtcctttctg ctagctgggt   2256

 ggtatctttt actgtgtttt tttgtttgtt tgtttttttg ttttttgtta cataaacccc   2316

 ttttattttg aaaaaaaaaa aa                                            2338




      <210> 132
      <211> 1463
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (431)..(1297)

      <400> 132
 cgtggcggag accgtctgga gcactgacac cggggaggca gtgtatcgct cccgggaccc     60

 cgtgcgcaac ttgcgcctcc gagtccacct gcaaagaatc acatcaagca actttcttca    120

 ttatcagcct gctgccgagc tcgggaagga cctcatagac ttggccactt ttaggcctca    180

 gccaactgcc agtggacacc gcccagagga agacgaagag gaggagattg tgattgggtg    240

 gcaggagaag ctctttagcc agtttgaagt agatctgtac caaaatgaaa cagcctgtca    300

 gagtcctttg gattatcagt accgtcagga gatcctgaag ctggagaatt cgggtggcaa    360

 gaaaaaccga cgaatcttta cctacactga ctctgataga tacaccaatt tggaggagca    420

 ctgtcagaga   atg acc act gca gcc agc gag gtg cct tca ttc ttg gtc     469
              Met Thr Thr Ala Ala Ser Glu Val Pro Ser Phe Leu Val
                1               5                  10

 gag cga atg gca aat gtc agg cgt cgc cgg cag gac agg cga ggg atg      517
 Glu Arg Met Ala Asn Val Arg Arg Arg Arg Gln Asp Arg Arg Gly Met
      15                  20                  25

 gag ggc ggc atc ctc aag tca cgc atc gtc acc tgg gag ccc tca gaa      565
 Glu Gly Gly Ile Leu Lys Ser Arg Ile Val Thr Trp Glu Pro Ser Glu
  30                  35                  40                  45

 gag ttt gtc agg aac aac cac gtc att aac acc cct ctt cag aca atg      613
 Glu Phe Val Arg Asn Asn His Val Ile Asn Thr Pro Leu Gln Thr Met
                  50                  55                  60

 cac atc atg gca gac ctg ggg ccc tat aaa aag ctt ggc tat aag aag      661
 His Ile Met Ala Asp Leu Gly Pro Tyr Lys Lys Leu Gly Tyr Lys Lys
              65                  70                  75

 tat gaa cat gtc ctg tgt act ctg aag gtg gat agc aat ggt gtg atc      709
 Tyr Glu His Val Leu Cys Thr Leu Lys Val Asp Ser Asn Gly Val Ile
          80                  85                  90

 aca gta aag cct gac ttc acg ggc ctc aaa gga ccc tac agg att gag      757
 Thr Val Lys Pro Asp Phe Thr Gly Leu Lys Gly Pro Tyr Arg Ile Glu
      95                 100                 105

 acg gag ggg gag aag cag gag ctg tgg aaa tat acg atc gac aat gtt      805
 Thr Glu Gly Glu Lys Gln Glu Leu Trp Lys Tyr Thr Ile Asp Asn Val
 110                 115                 120                 125

 tcc ccc cac gca cag ccg gag gag gag gag cgg gaa cgg cga gtg ttc      853
 Ser Pro His Ala Gln Pro Glu Glu Glu Glu Arg Glu Arg Arg Val Phe
                 130                 135                 140

 aag gat ctt tat ggc cgg cac aag gag tat ctc agc agc ctc gta ggc      901
 Lys Asp Leu Tyr Gly Arg His Lys Glu Tyr Leu Ser Ser Leu Val Gly
             145                 150                 155

 acc gac ttt gag atg act gtc cca ggt gcc ctc cgg ctc ttt gta aat      949
 Thr Asp Phe Glu Met Thr Val Pro Gly Ala Leu Arg Leu Phe Val Asn
         160                 165                 170

 gga gag gtc gtt tca gcc caa ggc tat gag tat gac aat ctc tac gtc      997
 Gly Glu Val Val Ser Ala Gln Gly Tyr Glu Tyr Asp Asn Leu Tyr Val
     175                 180                 185

 cac ttc ttt gta gaa ttg cca act gct cac tgg tca agc cca gca ttc     1045
 His Phe Phe Val Glu Leu Pro Thr Ala His Trp Ser Ser Pro Ala Phe
 190                 195                 200                 205

 cag cag ctc tca gga gta aca cag acc tgc acc acc aag tcc ctg gca     1093
 Gln Gln Leu Ser Gly Val Thr Gln Thr Cys Thr Thr Lys Ser Leu Ala
                 210                 215                 220

 atg gac aag gtg gct cac ttc tcc tac cca ttc acg ttt gaa gcc ttc     1141
 Met Asp Lys Val Ala His Phe Ser Tyr Pro Phe Thr Phe Glu Ala Phe
             225                 230                 235

 ttc ctc cat gag gat gaa tct tct gat gca ctc ccg gag tgg cct gtg     1189
 Phe Leu His Glu Asp Glu Ser Ser Asp Ala Leu Pro Glu Trp Pro Val
         240                 245                 250

 ctc tac tgt gag gtc ctc tcg ctg gac ttc tgg cag agg tac cgt gtg     1237
 Leu Tyr Cys Glu Val Leu Ser Leu Asp Phe Trp Gln Arg Tyr Arg Val
     255                 260                 265

 gaa ggc tat ggg gct gtg gtg ctg cct gcc act cca gcg aca atg acg     1285
 Glu Gly Tyr Gly Ala Val Val Leu Pro Ala Thr Pro Ala Thr Met Thr
 270                 275                 280                 285

 tgg cct tgg cac tga cttcctgaca gtctctccat gtgcttcatg ctcctctgat     1340
 Trp Pro Trp His 


 tggactcagg gtgagaagct gtatggcaaa attggctcat agcatatgtg tattgaatga   1400

 atcagcattc agtttggaat aaaagcatct gtcttttact gtgaaaaaaa aaaaaaaaaa   1460

 aaa                                                                 1463




      <210> 133
      <211> 1862
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4)..(1434)

      <400> 133
 gac  atg acg ccc gag gac cca gag gaa acc cag ccg ctt ctg ggg cct      48
      Met Thr Pro Glu Asp Pro Glu Glu Thr Gln Pro Leu Leu Gly Pro
        1               5                  10                  15

 cct ggc ggc agc gcg ccc cgc ggc cgc cgc gtc ttc ctc gcc gcc ttc       96
 Pro Gly Gly Ser Ala Pro Arg Gly Arg Arg Val Phe Leu Ala Ala Phe
                  20                  25                  30

 gcc gct gcc ctg ggc cca ctc agc ttc ggc ttc gcg ctc ggc tac agc      144
 Ala Ala Ala Leu Gly Pro Leu Ser Phe Gly Phe Ala Leu Gly Tyr Ser
              35                  40                  45

 tcc ccg gcc atc cct agc ctg cag cgc gcc gcg ccc ccg gcc ccg cgc      192
 Ser Pro Ala Ile Pro Ser Leu Gln Arg Ala Ala Pro Pro Ala Pro Arg
          50                  55                  60

 ctg gac gac gcc gcc gcc tcc tgg ttc ggg gct gtc gtg acc ctg ggt      240
 Leu Asp Asp Ala Ala Ala Ser Trp Phe Gly Ala Val Val Thr Leu Gly
      65                  70                  75

 gcc gcg gcg ggg gga gtg ctg ggc ggc tgg ctg gtg gac cgc gcc ggg      288
 Ala Ala Ala Gly Gly Val Leu Gly Gly Trp Leu Val Asp Arg Ala Gly
  80                  85                  90                  95

 cgc aag ctg agc ctc ttg ctg tgc tcc gtg ccc ttc gtg gcc ggc ttt      336
 Arg Lys Leu Ser Leu Leu Leu Cys Ser Val Pro Phe Val Ala Gly Phe
                 100                 105                 110

 gcc gtc atc acc gcg gcc cag gac gtg tgg atg ctg ctg ggg ggc cgc      384
 Ala Val Ile Thr Ala Ala Gln Asp Val Trp Met Leu Leu Gly Gly Arg
             115                 120                 125

 ctc ctc acc ggc ctg gcc tgc ggt gtt gcc tcc cta gtg gcc ccg gtc      432
 Leu Leu Thr Gly Leu Ala Cys Gly Val Ala Ser Leu Val Ala Pro Val
         130                 135                 140

 tac atc tcc gaa atc gcc tac cca gca gtc cgg ggg ttg ctc ggc tcc      480
 Tyr Ile Ser Glu Ile Ala Tyr Pro Ala Val Arg Gly Leu Leu Gly Ser
     145                 150                 155

 tgt gtg cag cta atg gtc gtc gtc ggc atc ctc ctg gcc tac ctg gca      528
 Cys Val Gln Leu Met Val Val Val Gly Ile Leu Leu Ala Tyr Leu Ala
 160                 165                 170                 175

 ggc tgg gtg ctg gag tgg cgc tgg ctg gct gtg ctg ggc tgc gtg ccc      576
 Gly Trp Val Leu Glu Trp Arg Trp Leu Ala Val Leu Gly Cys Val Pro
                 180                 185                 190

 ccc tcc ctc atg ctg ctt ctc atg tgc ttc atg ccc gag acc ccg cgc      624
 Pro Ser Leu Met Leu Leu Leu Met Cys Phe Met Pro Glu Thr Pro Arg
             195                 200                 205

 ttc ctg ctg act cag cac agg cgc cag gag gcc atg gcc gcc ctg cgg      672
 Phe Leu Leu Thr Gln His Arg Arg Gln Glu Ala Met Ala Ala Leu Arg
         210                 215                 220

 ttc ctg tgg ggc tcc gag cag ggc tgg gaa gac ccc ccc atc ggg gct      720
 Phe Leu Trp Gly Ser Glu Gln Gly Trp Glu Asp Pro Pro Ile Gly Ala
     225                 230                 235

 gag cag agc ttt cac ctg gcc ctg ctg cgg cag ccc ggc atc tac aag      768
 Glu Gln Ser Phe His Leu Ala Leu Leu Arg Gln Pro Gly Ile Tyr Lys
 240                 245                 250                 255

 ccc ttc atc atc ggt gtc tcc ctg atg gcc ttc cag cag ctg tcg ggg      816
 Pro Phe Ile Ile Gly Val Ser Leu Met Ala Phe Gln Gln Leu Ser Gly
                 260                 265                 270

 gtc aac gcc gtc atg ttc tat gca gag acc atc ttt gaa gag gcc aag      864
 Val Asn Ala Val Met Phe Tyr Ala Glu Thr Ile Phe Glu Glu Ala Lys
             275                 280                 285

 ttc aag gac agc agc ctg gcc tcg gtc gtc gtg ggt gtc atc cag gtg      912
 Phe Lys Asp Ser Ser Leu Ala Ser Val Val Val Gly Val Ile Gln Val
         290                 295                 300

 ctg ttc aca gct gtg gcg gct ctc atc atg gac aga gca ggg cgg agg      960
 Leu Phe Thr Ala Val Ala Ala Leu Ile Met Asp Arg Ala Gly Arg Arg
     305                 310                 315

 ctg ctc ctg gtc ttg tca ggt gtg gtc atg gtg ttc agc acg agt gcc     1008
 Leu Leu Leu Val Leu Ser Gly Val Val Met Val Phe Ser Thr Ser Ala
 320                 325                 330                 335

 ttc ggc gcc tac ttc aag ctg acc cag ggt ggc cct ggc aac tcc tcg     1056
 Phe Gly Ala Tyr Phe Lys Leu Thr Gln Gly Gly Pro Gly Asn Ser Ser
                 340                 345                 350

 cac gtg gcc atc tcg gcg cct gtc tct gca cag cct gtt gat gcc agc     1104
 His Val Ala Ile Ser Ala Pro Val Ser Ala Gln Pro Val Asp Ala Ser
             355                 360                 365

 gtg ggg ctg gcc tgg ctg gcc gtg ggc agc atg tgc ctc ttc atc gcc     1152
 Val Gly Leu Ala Trp Leu Ala Val Gly Ser Met Cys Leu Phe Ile Ala
         370                 375                 380

 ggc ttt gcg gtg ggc tgg ggg ccc atc ccc tgg ctc ctc atg tca gag     1200
 Gly Phe Ala Val Gly Trp Gly Pro Ile Pro Trp Leu Leu Met Ser Glu
     385                 390                 395

 atc ttc cct ctg cat gtc aag ggc gtg gcg aca ggc atc tgc gtc ctc     1248
 Ile Phe Pro Leu His Val Lys Gly Val Ala Thr Gly Ile Cys Val Leu
 400                 405                 410                 415

 acc aac tgg ctc atg gcc ttt ctc gtg acc aag gag ttc agc agc ctc     1296
 Thr Asn Trp Leu Met Ala Phe Leu Val Thr Lys Glu Phe Ser Ser Leu
                 420                 425                 430

 atg gag gtc ctc agg ccc tat gga gcc ttc tgg ctt gcc tcc gct ttc     1344
 Met Glu Val Leu Arg Pro Tyr Gly Ala Phe Trp Leu Ala Ser Ala Phe
             435                 440                 445

 tgc atc ttc agt gtc ctt ttc act ttg ttc tgt gtc cct gaa act aaa     1392
 Cys Ile Phe Ser Val Leu Phe Thr Leu Phe Cys Val Pro Glu Thr Lys
         450                 455                 460

 gga aag act ctg gaa caa atc aca gcc cat ttt gag ggg cga tgacagc     1441
 Gly Lys Thr Leu Glu Gln Ile Thr Ala His Phe Glu Gly Arg 
     465                 470                 475

 cactcactag gggatggagc aagcctgtga ctccaagctg ggcccaagcc cagagcccct   1501

 gcctgcccca ggggagccag aatccagccc cttggagcct tggtctgcag ggtccctcct   1561

 tcctgtcatg ctccctccag cccatgaccc ggggctagga ggctcactgc ctcctgttcc   1621

 agctcctgct gctgctctga ggactcagga acaccttcga gctttgcaga cctgcggtca   1681

 gccctccatg cgcaagacta aagcagcgga agaggaggtg ggcctctagg atctttgtct   1741

 tctggctgga ggtgcttttg gaggttgggt gctgggcatt cggtcgctcc tctcacgcgg   1801

 ctgccttatc gggaaggaaa tttgtttgcc aaataaagac tgacacagaa aaaaaaaaaa   1861

 a                                                                   1862




      <210> 134
      <211> 1655
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4)..(1227)

      <400> 134
 gac  atg acg ccc gag gac cca gag gaa acc cag ccg ctt ctg ggg cct      48
      Met Thr Pro Glu Asp Pro Glu Glu Thr Gln Pro Leu Leu Gly Pro
        1               5                  10                  15

 cct ggc ggc agc gcg ccc cgc ggc cgc cgc gtc ttc ctc gcc gcc ttc       96
 Pro Gly Gly Ser Ala Pro Arg Gly Arg Arg Val Phe Leu Ala Ala Phe
                  20                  25                  30

 gcc gct gcc ctg ggc cca ctc agc ttc ggc ttc gcg ctc ggc tac agc      144
 Ala Ala Ala Leu Gly Pro Leu Ser Phe Gly Phe Ala Leu Gly Tyr Ser
              35                  40                  45

 tcc ccg gcc atc cct agc ctg cag cgc gcc gcg ccc ccg gcc ccg cgc      192
 Ser Pro Ala Ile Pro Ser Leu Gln Arg Ala Ala Pro Pro Ala Pro Arg
          50                  55                  60

 ctg gac gac gcc gcc gcc tcc tgg ttc ggg gtc tac atc tcc gaa atc      240
 Leu Asp Asp Ala Ala Ala Ser Trp Phe Gly Val Tyr Ile Ser Glu Ile
      65                  70                  75

 gcc tac cca gca gtc cgg ggg ttg ctc ggc tcc tgt gtg cag cta atg      288
 Ala Tyr Pro Ala Val Arg Gly Leu Leu Gly Ser Cys Val Gln Leu Met
  80                  85                  90                  95

 gtc gtc gtc ggc atc ctc ctg gcc tac ctg gca ggc tgg gtg ctg gag      336
 Val Val Val Gly Ile Leu Leu Ala Tyr Leu Ala Gly Trp Val Leu Glu
                 100                 105                 110

 tgg cgc tgg ctg gct gtg ctg ggc tgc gtg ccc ccc tcc ctc atg ctg      384
 Trp Arg Trp Leu Ala Val Leu Gly Cys Val Pro Pro Ser Leu Met Leu
             115                 120                 125

 ctt ctc atg tgc ttc atg ccc gag acc ccg cgc ttc ctg ctg act cag      432
 Leu Leu Met Cys Phe Met Pro Glu Thr Pro Arg Phe Leu Leu Thr Gln
         130                 135                 140

 cac agg cgc cag gag gcc atg gcc gcc ctg cgg ttc ctg tgg ggc tcc      480
 His Arg Arg Gln Glu Ala Met Ala Ala Leu Arg Phe Leu Trp Gly Ser
     145                 150                 155

 gag cag ggc tgg gaa gac ccc ccc atc ggg gct gag cag agc ttt cac      528
 Glu Gln Gly Trp Glu Asp Pro Pro Ile Gly Ala Glu Gln Ser Phe His
 160                 165                 170                 175

 ctg gcc ctg ctg cgg cag ccc ggc atc tac aag ccc ttc atc atc ggt      576
 Leu Ala Leu Leu Arg Gln Pro Gly Ile Tyr Lys Pro Phe Ile Ile Gly
                 180                 185                 190

 gtc tcc ctg atg gcc ttc cag cag ctg tcg ggg gtc aac gcc gtc atg      624
 Val Ser Leu Met Ala Phe Gln Gln Leu Ser Gly Val Asn Ala Val Met
             195                 200                 205

 ttc tat gca gag acc atc ttt gaa gag gcc aag ttc aag gac agc agc      672
 Phe Tyr Ala Glu Thr Ile Phe Glu Glu Ala Lys Phe Lys Asp Ser Ser
         210                 215                 220

 ctg gcc tcg gtc gtc gtg ggt gtc atc cag gtg ctg ttc aca gct gtg      720
 Leu Ala Ser Val Val Val Gly Val Ile Gln Val Leu Phe Thr Ala Val
     225                 230                 235

 gcg gct ctc atc atg gac aga gca ggg cgg agg ctg ctc ctg gtc ttg      768
 Ala Ala Leu Ile Met Asp Arg Ala Gly Arg Arg Leu Leu Leu Val Leu
 240                 245                 250                 255

 tca ggt gtg gtc atg gtg ttc agc acg agt gcc ttc ggc gcc tac ttc      816
 Ser Gly Val Val Met Val Phe Ser Thr Ser Ala Phe Gly Ala Tyr Phe
                 260                 265                 270

 aag ctg acc cag ggt ggc cct ggc aac tcc tcg cac gtg gcc atc tcg      864
 Lys Leu Thr Gln Gly Gly Pro Gly Asn Ser Ser His Val Ala Ile Ser
             275                 280                 285

 gcg cct gtc tct gca cag cct gtt gat gcc agc gtg ggg ctg gcc tgg      912
 Ala Pro Val Ser Ala Gln Pro Val Asp Ala Ser Val Gly Leu Ala Trp
         290                 295                 300

 ctg gcc gtg ggc agc atg tgc ctc ttc atc gcc ggc ttt gcg gtg ggc      960
 Leu Ala Val Gly Ser Met Cys Leu Phe Ile Ala Gly Phe Ala Val Gly
     305                 310                 315

 tgg ggg ccc atc ccc tgg ctc ctc atg tca gag atc ttc cct ctg cat     1008
 Trp Gly Pro Ile Pro Trp Leu Leu Met Ser Glu Ile Phe Pro Leu His
 320                 325                 330                 335

 gtc aag ggc gtg gcg aca ggc atc tgc gtc ctc acc aac tgg ctc atg     1056
 Val Lys Gly Val Ala Thr Gly Ile Cys Val Leu Thr Asn Trp Leu Met
                 340                 345                 350

 gcc ttt ctc gtg acc aag gag ttc agc agc ctc atg gag gtc ctc agg     1104
 Ala Phe Leu Val Thr Lys Glu Phe Ser Ser Leu Met Glu Val Leu Arg
             355                 360                 365

 ccc tat gga gcc ttc tgg ctt gcc tcc gct ttc tgc atc ttc agt gtc     1152
 Pro Tyr Gly Ala Phe Trp Leu Ala Ser Ala Phe Cys Ile Phe Ser Val
         370                 375                 380

 ctt ttc act ttg ttc tgt gtc cct gaa act aaa gga aag act ctg gaa     1200
 Leu Phe Thr Leu Phe Cys Val Pro Glu Thr Lys Gly Lys Thr Leu Glu
     385                 390                 395

 caa atc aca gcc cat ttt gag ggg cga tgaca gccactcact aggggatgga     1252
 Gln Ile Thr Ala His Phe Glu Gly Arg 
 400                 405

 gcaagcctgt gactccaagc tgggcccaag cccagagccc ctgcctgccc caggggagcc   1312

 agaatccagc cccttggagc cttggtctgc agggtccctc cttcctgtca tgctccctcc   1372

 agcccatgac ccggggctag gaggctcact gcctcctgtt ccagctcctg ctgctgctct   1432

 gaggactcag gaacaccttc gagctttgca gacctgcggt cagccctcca tgcgcaagac   1492

 taaagcagcg gaagaggagg tgggcctcta ggatctttgt cttctggctg gaggtgcttt   1552

 tggaggttgg gtgctgggca ttcggtcgct cctctcacgc ggctgcctta tcgggaagga   1612

 aatttgtttg ccaaataaag actgacacag aaaaaaaaaa aaa                     1655




      <210> 135
      <211> 1218
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (205)..(921)

      <400> 135
 gacgcgggcc gagccggaag tggagtgtgc tgcggcgcga gctgggccgg cgggcgtggt     60

 tcgagagcgc gcagagtcca gactggcggc agggcccgag gggccgaccc gcagcgtccc    120

 tggtctctcc agccctcact cggaaccgca ctgacaatac cctcccctcc cttgggctgg    180

 acccctctct acagctagga gcca   atg gca gaa gac aaa acc aaa ccg agt     231
                              Met Ala Glu Asp Lys Thr Lys Pro Ser
                                1               5

 gag ttg gac caa ggg aag tat gat gct gat gac aac gtg aag atc atc      279
 Glu Leu Asp Gln Gly Lys Tyr Asp Ala Asp Asp Asn Val Lys Ile Ile
  10                  15                  20                  25

 tgc ctg gga gac agc gca gtg ggc aaa tcc aaa ctc atg gag aga ttt      327
 Cys Leu Gly Asp Ser Ala Val Gly Lys Ser Lys Leu Met Glu Arg Phe
                  30                  35                  40

 ctc atg gat ggc ttt cag cca cag cag ctg tcc acg tac gcc ctg acc      375
 Leu Met Asp Gly Phe Gln Pro Gln Gln Leu Ser Thr Tyr Ala Leu Thr
              45                  50                  55

 ctg tac aag cac aca gcc acg gta gat ggc aag acc atc ctt gtg gac      423
 Leu Tyr Lys His Thr Ala Thr Val Asp Gly Lys Thr Ile Leu Val Asp
          60                  65                  70

 ttt tgg gac acg gca ggc cag gag cgg ttc cag agc atg cat gcc tcc      471
 Phe Trp Asp Thr Ala Gly Gln Glu Arg Phe Gln Ser Met His Ala Ser
      75                  80                  85

 tac tac cac aag gcc cac gcc tgc atc atg gtg ttt gat gta cag agg      519
 Tyr Tyr His Lys Ala His Ala Cys Ile Met Val Phe Asp Val Gln Arg
  90                  95                 100                 105

 aaa gtc acc tat agg aac ctg agc acc tgg tat aca gag ctt cgg gag      567
 Lys Val Thr Tyr Arg Asn Leu Ser Thr Trp Tyr Thr Glu Leu Arg Glu
                 110                 115                 120

 ttc agg cca gag atc cca tgc atc gtg gtg gcc aat aaa att gat gca      615
 Phe Arg Pro Glu Ile Pro Cys Ile Val Val Ala Asn Lys Ile Asp Ala
             125                 130                 135

 gac ata aac gtg acc caa aaa agc ttc aat ttt gcc aag aag ttc tcc      663
 Asp Ile Asn Val Thr Gln Lys Ser Phe Asn Phe Ala Lys Lys Phe Ser
         140                 145                 150

 ctg ccc ctg tat ttc gtc tcg gct gct gat ggt acc aat gtt gtg aag      711
 Leu Pro Leu Tyr Phe Val Ser Ala Ala Asp Gly Thr Asn Val Val Lys
     155                 160                 165

 gtg tgg ttg act gca gag gta gct agc aag ctc ttc aat gat gca att      759
 Val Trp Leu Thr Ala Glu Val Ala Ser Lys Leu Phe Asn Asp Ala Ile
 170                 175                 180                 185

 cga tta gct gtg tct tac aaa cag aac tcc cag gac ttc atg gat gag      807
 Arg Leu Ala Val Ser Tyr Lys Gln Asn Ser Gln Asp Phe Met Asp Glu
                 190                 195                 200

 att ttt cag gag ctc gag aac ttc agc ttg gag cag gaa gag gag gac      855
 Ile Phe Gln Glu Leu Glu Asn Phe Ser Leu Glu Gln Glu Glu Glu Asp
             205                 210                 215

 gtg cca gac cag gaa cag agc agc agc atc gag acc cca tca gag gag      903
 Val Pro Asp Gln Glu Gln Ser Ser Ser Ile Glu Thr Pro Ser Glu Glu
         220                 225                 230

 gtg gcc tct ccc cac agc tgaggg gctggggcta ggggtgggtg gagccctttt      957
 Val Ala Ser Pro His Ser 
     235

 aaaataccct tcccttcaac aactctccag ctctgaatgg agaaactctc taggccatcc   1017

 cctcttctac ctcctgcaac ccacccatcc tattagcctc ccacattcta ggcccgtgat   1077

 acagggatga ggtcagcacc agcaaactct ggactggtgg aagaattccc caccagatct   1137

 ccttgaagca gaagtaggga tcagcatcat taacaccttc cccaccccct ccccgcaggc   1197

 agacagtgaa gagaatcaga a                                             1218




      <210> 136
      <211> 1842
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (934)..(1839)

      <400> 136
 tcagccagct ggactcagtt tagacgatcc caattttgtt gcaacatcca aagcttcata     60

 atcaggagcc agtcgaacat atgccttgtt ctctttatca ggaaaaatca gggtggtgac    120

 cttggccaca tcactgtcat agagcttctt cacagcctgt ttgatctggt gcttgttggc    180

 tttaacatcc acgaagaaca caagcatgtt gttttcttct atcttcttcc ggcccattga    240

 tagcatagtg gccaagcttg tttctcctgg gggtgctctt ccgaggatat ctgggctgcc    300

 tccggagtcg cagtgtcttg ggccgcctga aggtgagtga catgcggatc ttcttttttg    360

 cgtgtggctg cggacacctt tcaacactgc cttcttggcc tttaaagcct tcactttggc    420

 ttcggcttta ggaggagcag gagcttcctt cgctttcggt gccgtcttcc tcaatggcct    480

 gcagccacgt ctccccaggt cagtcttaag gacaacgaaa ctctggtctt cactgtggac    540

 atgccacact accaggtgct ccaaagccat ggtgacccat cctcaggcgg gcggcacccg    600

 ctgaagcctc agtaccacac ccacagccag gagccccagt cccgcactcg gccgcatgcg    660

 cactcctgcg gccctcccgc caggcgccgc tgggcagcca gcgaccggcg gggtccttca    720

 cgttcggccg ggcagcctcc ctcggggtcc ttgcgcggtt gcgtagcagc tgcgaggacg    780

 cggggcgagc cggaagtgga gtcgctgcgg cgcgagctgg gccggcgggc gtggttcgag    840

 agcgcgcaga gtccagactg gcggcagggc ccgaaggggc cgacccgcag cgtccctggt    900

 ctctccagcc ctcactcgga accgcacgag cca atg gca gaa gac aaa acc aaa     954
                                      Met Ala Glu Asp Lys Thr Lys
                                        1               5

 ccg agt gag ttg gac caa ggg aag tat gat gct gat gac aac gtg aag     1002
 Pro Ser Glu Leu Asp Gln Gly Lys Tyr Asp Ala Asp Asp Asn Val Lys
          10                  15                  20

 atc atc tgc ctg gga gac agc gca gtg ggc aaa tcc aaa ctc atg gag     1050
 Ile Ile Cys Leu Gly Asp Ser Ala Val Gly Lys Ser Lys Leu Met Glu
      25                  30                  35

 aga ttt ctc atg gat ggc ttg tat cct tca agg ttt gaa gta ctc ctt     1098
 Arg Phe Leu Met Asp Gly Leu Tyr Pro Ser Arg Phe Glu Val Leu Leu
  40                  45                  50                  55

 gtt cct gtg ggt ctt ccc acg ctc atg tat cag tgt ccc act gcc cac     1146
 Val Pro Val Gly Leu Pro Thr Leu Met Tyr Gln Cys Pro Thr Ala His
                  60                  65                  70

 ccc ttt gta cca gca gcc cag gaa cag gaa gga gga ttg gac ttc gat     1194
 Pro Phe Val Pro Ala Ala Gln Glu Gln Glu Gly Gly Leu Asp Phe Asp
              75                  80                  85

 ggc cag gac aca ctc tca tct cct ccc acc cct cac cct tcc atg gag     1242
 Gly Gln Asp Thr Leu Ser Ser Pro Pro Thr Pro His Pro Ser Met Glu
          90                  95                 100

 ctt gta cca gtg tgc agt cag cca cag cag ctg tcc acg tac gcc ctg     1290
 Leu Val Pro Val Cys Ser Gln Pro Gln Gln Leu Ser Thr Tyr Ala Leu
     105                 110                 115

 acc ctg tac aag cac aca gcc acg gta gat ggc aag acc atc ctt gtg     1338
 Thr Leu Tyr Lys His Thr Ala Thr Val Asp Gly Lys Thr Ile Leu Val
 120                 125                 130                 135

 gac ttt tgg gac acg gca ggc cag gag cgg ttc cag agc atg cat gcc     1386
 Asp Phe Trp Asp Thr Ala Gly Gln Glu Arg Phe Gln Ser Met His Ala
                 140                 145                 150

 tcc tac tac cac aag gcc cat gcc tgc atc atg gtg ttt gat ata cag     1434
 Ser Tyr Tyr His Lys Ala His Ala Cys Ile Met Val Phe Asp Ile Gln
             155                 160                 165

 agg aaa gtc acc tat agg aac ctg agc acc tgg tat aca gag ctt cgg     1482
 Arg Lys Val Thr Tyr Arg Asn Leu Ser Thr Trp Tyr Thr Glu Leu Arg
         170                 175                 180

 gag ttc agg cca gag atc cca tgc atc gtg gtg gcc aat aaa att gat     1530
 Glu Phe Arg Pro Glu Ile Pro Cys Ile Val Val Ala Asn Lys Ile Asp
     185                 190                 195

 gca gac ata aac gtg acc caa aaa agc ttc aat ttt gcc aag aag ttc     1578
 Ala Asp Ile Asn Val Thr Gln Lys Ser Phe Asn Phe Ala Lys Lys Phe
 200                 205                 210                 215

 tcc ctg ccc ctg tat ttc gtc tcg gct gct gat ggt acc aat gtt gtg     1626
 Ser Leu Pro Leu Tyr Phe Val Ser Ala Ala Asp Gly Thr Asn Val Val
                 220                 225                 230

 aag gtg tgg ttg act gca gag gta gct agc aag ctc ttc aat gat gca     1674
 Lys Val Trp Leu Thr Ala Glu Val Ala Ser Lys Leu Phe Asn Asp Ala
             235                 240                 245

 att cga tta gct gtg tct tac aaa cag aac tcc cag gac ttc atg gat     1722
 Ile Arg Leu Ala Val Ser Tyr Lys Gln Asn Ser Gln Asp Phe Met Asp
         250                 255                 260

 gag att ttt cag gag ctc gag aac ttc agc ttg gag cag gaa gag gag     1770
 Glu Ile Phe Gln Glu Leu Glu Asn Phe Ser Leu Glu Gln Glu Glu Glu
     265                 270                 275

 gac gtg cca gac cag gaa cag agc agc agc atc gag acc cca tca gag     1818
 Asp Val Pro Asp Gln Glu Gln Ser Ser Ser Ile Glu Thr Pro Ser Glu
 280                 285                 290                 295

 gag gtg gcc tct ccc cac agc tga                                     1842
 Glu Val Ala Ser Pro His Ser 
                 300





      <210> 137
      <211> 510
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (17)..(319)

      <400> 137
 ctacagctag gagcca    atg gca gaa gac tta acc aaa ccg agt gag ttg      49
                      Met Ala Glu Asp Leu Thr Lys Pro Ser Glu Leu
                        1               5                  10

 gac caa ggg aag tat gat gct gat gac aac gtg aag atc att tgc ctg       97
 Asp Gln Gly Lys Tyr Asp Ala Asp Asp Asn Val Lys Ile Ile Cys Leu
              15                  20                  25

 gga gac agc gca gtg ggc aaa tcc aaa ctc atg gag aga ttt ctc atg      145
 Gly Asp Ser Ala Val Gly Lys Ser Lys Leu Met Glu Arg Phe Leu Met
          30                  35                  40

 gat ggc ttt cag cca cag cag ctg tcc acg tac gcc ctg acc ctg tac      193
 Asp Gly Phe Gln Pro Gln Gln Leu Ser Thr Tyr Ala Leu Thr Leu Tyr
      45                  50                  55

 aag cac aca gcc acg gta gat ggc aag acc atc ctt gtg gac ttt tgg      241
 Lys His Thr Ala Thr Val Asp Gly Lys Thr Ile Leu Val Asp Phe Trp
  60                  65                  70                  75

 gac acg gca ggc cag gag cgg ttc cag agc atg cat gcc tcc tac tac      289
 Asp Thr Ala Gly Gln Glu Arg Phe Gln Ser Met His Ala Ser Tyr Tyr
                  80                  85                  90

 cac aag gcc cat gcc tgc atc atg cag aca t aaacgtgacc caaaaaagct      340
 His Lys Ala His Ala Cys Ile Met Gln Thr 
              95                 100

 tcaattttgc caagaagttc tccctgcccc tgtatttcgt ctcggctgct gatggtacca    400

 atgttgtgaa gctcttcaat gatgcaattc gattagctgt gtcttacaaa cagaactccc    460

 aggacttcat ggatgagatt tttcaggagc tcgagaactt cagcttggag               510




      <210> 138
      <211> 2440
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1018)..(1533)

      <400> 138
 gccagagggc cggggccggg gccgcgaccc gcatcgggat cgcacccgct cccgctcccg     60

 ctcgcggtcc cctttgtcgc ccaggtcccg ccgcggctct gcgcgggagc gcagagaggc    120

 cccagagcgc ccgagcctgg aggacacaga gccgtcggat tccggggacg agatgatgga    180

 cccggccagc ttggaggcgg aggccgacca aggcctgtgc cgccagatcc gccatcagta    240

 ccgggcgctc atcaactccg tccaacgtaa ggcggcgcct ccgggcggcg cgggcccgga    300

 cgggccgctg tccccgccct gcgccgggcg cggggggagg gcaccggagg caggtgccgg    360

 gcggaggccc ggcgcggcgt tagtagagac gcgccgggtg ccagcccctc gccgcacctt    420

 aaattgttga caaagtgctc ccactttgtg gctggagccg tacgaccttg gcgcgggtcc    480

 ccgagtggcg ggctggaaaa gctggaggcc agagccgttc gcggactcgc ccgagcccag    540

 ccagccagtg gggagagcat gacgcggacc tcgcgtgcta tgattgcgcc ccgcagtgct    600

 cgggcgtggc tcccagcctc gcagcggcag ctgcagctgg cagcgaacgc gagagctggc    660

 aatgcacgtt ctcggacccc acccggaccc gcgttttttt aatctctggg tggctccgcg    720

 caactgtgga gtggccctcc aggtgatggt gtgtgttgct tgcaaagctt gagaaccact    780

 cagttatggt gcactcaaag gctgcagccg gagtccagcc ctttggttta agaaaaccgt    840

 gaggacatac tgaatgccgg tgacaaatta acagaggtcc ttgaagaggc taacactctg    900

 tttaatgaag tgtcccgagc aagagaagca gtcctggatg cccactttct tgttttggct    960

 tcagatttgg gcaaagagaa agcaaagcag ctgcgctcag acctgagctc ctttgac      1017                                                                 
 atg tta aga tat gtt gaa act cta ctc aca cat atg ggt gta aat ccg     1065
 Met Leu Arg Tyr Val Glu Thr Leu Leu Thr His Met Gly Val Asn Pro
   1               5                  10                  15

 cta gaa gct gaa gaa ctc atc cgt gat gaa gat agt cct gat ttt gaa     1113
 Leu Glu Ala Glu Glu Leu Ile Arg Asp Glu Asp Ser Pro Asp Phe Glu
              20                  25                  30

 ttc ata gtc tat gac tcc tgg aag ata aca ggc aga aca gca gaa aac     1161
 Phe Ile Val Tyr Asp Ser Trp Lys Ile Thr Gly Arg Thr Ala Glu Asn
          35                  40                  45

 acc ttt aat aaa acc cat aca ttc cac ttt ctg ttg ggt tca ata tac     1209
 Thr Phe Asn Lys Thr His Thr Phe His Phe Leu Leu Gly Ser Ile Tyr
      50                  55                  60

 gga gag tgc cct gtg cca aag cca cga gtt gat cgt cca aga aaa gtt     1257
 Gly Glu Cys Pro Val Pro Lys Pro Arg Val Asp Arg Pro Arg Lys Val
  65                  70                  75                  80

 cct gtg ata caa gag gag agg gca atg cct gcc cag tta aga aga atg     1305
 Pro Val Ile Gln Glu Glu Arg Ala Met Pro Ala Gln Leu Arg Arg Met
                  85                  90                  95

 gaa gaa tct cat caa gaa gca aca gag aaa gaa gta gaa aga atc ttg     1353
 Glu Glu Ser His Gln Glu Ala Thr Glu Lys Glu Val Glu Arg Ile Leu
             100                 105                 110

 gga ttg ttg cag aca tat ttt cga gaa gat cct gat acc cca atg tcc     1401
 Gly Leu Leu Gln Thr Tyr Phe Arg Glu Asp Pro Asp Thr Pro Met Ser
         115                 120                 125

 ttc ttt gac ttt gtg gtt gat cct cat tct ttc ccc cgt aca gtg gaa     1449
 Phe Phe Asp Phe Val Val Asp Pro His Ser Phe Pro Arg Thr Val Glu
     130                 135                 140

 aac atc ttt cat gtt tcc ttc att ata cgg gat ggt ttt gca aga ata     1497
 Asn Ile Phe His Val Ser Phe Ile Ile Arg Asp Gly Phe Ala Arg Ile
 145                 150                 155                 160

 aga ctt gac caa gac cga ctg cca gta ata ggt aaa tgat actatgtttg     1547
 Arg Leu Asp Gln Asp Arg Leu Pro Val Ile Gly Lys 
                 165                 170

 gaaaaattag ttttagagaa aatatatttg ttagtagaat ttaagtattt tactaaatgt   1607

 aaatgaattt tcaatgtaga ttaactttta caatattgta tcttgctcaa ctacctgaag   1667

 atactgaaaa catggccagc gtctaaaatt ttgatggatt catctatatc attgattcaa   1727

 catctgctgt aaatattaac aaagaaatga tataatttcc ctcagatctt aatttagaaa   1787

 gttggtgatt gcagtcattt ttgtagtatc cctctttcta atcacgtttt gtcagatgcc   1847

 ggcaccttct tttctctttg aggttctatg aatctttcat tcttacctga ataatttcac   1907

 actctccatt actcatgtcc tcctaaggtc tcctgtggag agtgaatatt tccatcgcac   1967

 ttacttgcta ctttcaatgt tctcaatgtc ctattggact cactagggct tagctctgtg   2027

 gttgacacat agatatgcag attttcaaat gtctggaatg tgttactcta ctacatgttt   2087

 tttgaaatgg aaacagatgg aatgactggc tactgtaata atactacagc agctccataa   2147

 tgcatgaaat cctaaaaagt atgtaatatt ataagtatct tttcaataca ggtttcattg   2207

 cgaataatca tccagtttcc gttaggaatc cctgttccga tttaataacc ctttggtaaa   2267

 tttgaaaaat ttgtctttcc aacagagcct gttaggtatt aatggaagaa atgaggggtt   2327

 tggacattac acacaagttt ggaatccagg gattatagct ttgaggtttc gtgcctggga   2387

 ggttaactct gcctggtgcc ctgccaagtc ttgctctgct tcattgcaga tta          2440




      <210> 139
      <211> 2270
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (159)..(1337)

      <400> 139
 tgcggagcct gcatctctga agctgcctcg gtgaagagcc acagcattat tttttttctc     60

 tttgggagag tagctgtctg ggatttgaga tcctatcttc cctgcaaatt accaggttgc    120

 atcttcactg ataggaatac atttcttcac caaaggac    atg gat gaa aat gaa     173
                                              Met Asp Glu Asn Glu
                                                1               5

 agc aac cag tct ctg atg aca agc agc caa tat cct aaa gaa gca gta      221
 Ser Asn Gln Ser Leu Met Thr Ser Ser Gln Tyr Pro Lys Glu Ala Val
                  10                  15                  20

 aga aaa cgt caa aat tca gca cgg aat tcc gga gca agt gat tct tct      269
 Arg Lys Arg Gln Asn Ser Ala Arg Asn Ser Gly Ala Ser Asp Ser Ser
              25                  30                  35

 agg ttt tct agg aaa agc ttc aaa ctg gat tat aga cta gaa gaa gat      317
 Arg Phe Ser Arg Lys Ser Phe Lys Leu Asp Tyr Arg Leu Glu Glu Asp
          40                  45                  50

 gta act aaa tcc aag aaa gga aaa gat ggg aga ttt gtg aat ccg tgg      365
 Val Thr Lys Ser Lys Lys Gly Lys Asp Gly Arg Phe Val Asn Pro Trp
      55                  60                  65

 cca aca tgg aaa aac ccc tct att cca aat gtt ctc aga tgg ctg ata      413
 Pro Thr Trp Lys Asn Pro Ser Ile Pro Asn Val Leu Arg Trp Leu Ile
  70                  75                  80                  85

 atg gag aaa gat cac agc agt gtt cca agt tct aaa gag gaa cta gac      461
 Met Glu Lys Asp His Ser Ser Val Pro Ser Ser Lys Glu Glu Leu Asp
                  90                  95                 100

 aaa gaa ctc cca gtg ctt aag cca tat ttt atc act aac cct gaa gaa      509
 Lys Glu Leu Pro Val Leu Lys Pro Tyr Phe Ile Thr Asn Pro Glu Glu
             105                 110                 115

 gct gga gtg agg gaa gct ggc tta aga gtc aca tgg ctg gga cat gcc      557
 Ala Gly Val Arg Glu Ala Gly Leu Arg Val Thr Trp Leu Gly His Ala
         120                 125                 130

 acg gta atg gtg gaa atg gat gag ctc ata ttt ctc acg gat ccc atc      605
 Thr Val Met Val Glu Met Asp Glu Leu Ile Phe Leu Thr Asp Pro Ile
     135                 140                 145

 ttt agc tct cgt gct tca cca tcg cag tac atg ggt cca aag cga ttt      653
 Phe Ser Ser Arg Ala Ser Pro Ser Gln Tyr Met Gly Pro Lys Arg Phe
 150                 155                 160                 165

 cgt cgt tcc ccg tgc aca ata agt gaa ctc cct cca ata gat gcg gtc      701
 Arg Arg Ser Pro Cys Thr Ile Ser Glu Leu Pro Pro Ile Asp Ala Val
                 170                 175                 180

 ctt atc agt cac aac cac tat gac cat ctg gac tac aat tct gtc att      749
 Leu Ile Ser His Asn His Tyr Asp His Leu Asp Tyr Asn Ser Val Ile
             185                 190                 195

 gct ttg aat gag cga ttt ggt aat gag ttg aga tgg ttt gtg cct ttg      797
 Ala Leu Asn Glu Arg Phe Gly Asn Glu Leu Arg Trp Phe Val Pro Leu
         200                 205                 210

 ggt ctc ctt gac tgg atg caa aaa tgt ggc tgt gag aat gtg att gag      845
 Gly Leu Leu Asp Trp Met Gln Lys Cys Gly Cys Glu Asn Val Ile Glu
     215                 220                 225

 ttg gac tgg tgg gag gag aat tgt gtc ccc gga cat gat aag gtc act      893
 Leu Asp Trp Trp Glu Glu Asn Cys Val Pro Gly His Asp Lys Val Thr
 230                 235                 240                 245

 ttt gtc ttt aca cct tcc cag cac tgg tgt aaa agg act cta atg gat      941
 Phe Val Phe Thr Pro Ser Gln His Trp Cys Lys Arg Thr Leu Met Asp
                 250                 255                 260

 gac aac aag gtg cta tgg ggc agc tgg tct gtc ttg ggg cct tgg aat      989
 Asp Asn Lys Val Leu Trp Gly Ser Trp Ser Val Leu Gly Pro Trp Asn
             265                 270                 275

 cga ttt ttt ttc gca gga gat act ggt tat tgc cct gct ttt gaa gag     1037
 Arg Phe Phe Phe Ala Gly Asp Thr Gly Tyr Cys Pro Ala Phe Glu Glu
         280                 285                 290

 ata gga aaa aga ttt gga cct ttt gac ctt gca gct att ccc atc gga     1085
 Ile Gly Lys Arg Phe Gly Pro Phe Asp Leu Ala Ala Ile Pro Ile Gly
     295                 300                 305

 gct tat gaa ccg agg tgg ttt atg aaa tac cag cat gta gac cca gaa     1133
 Ala Tyr Glu Pro Arg Trp Phe Met Lys Tyr Gln His Val Asp Pro Glu
 310                 315                 320                 325

 gaa gct gta agg att cac act gat gtc caa aca aag aaa tct atg gca     1181
 Glu Ala Val Arg Ile His Thr Asp Val Gln Thr Lys Lys Ser Met Ala
                 330                 335                 340

 att cac tgg gga act ttt gcc tta gca aat gag cat tac tta gag cct     1229
 Ile His Trp Gly Thr Phe Ala Leu Ala Asn Glu His Tyr Leu Glu Pro
             345                 350                 355

 cca gtg aag ctg aat gaa gct cta gag aga tac gga ctt aac gct gaa     1277
 Pro Val Lys Leu Asn Glu Ala Leu Glu Arg Tyr Gly Leu Asn Ala Glu
         360                 365                 370

 gat ttt ttt gtc ttg aag cat gga gaa tca aga tac cta aat aat aat     1325
 Asp Phe Phe Val Leu Lys His Gly Glu Ser Arg Tyr Leu Asn Asn Asn
     375                 380                 385

 gat gaa aac ttt taa taaatgtgag cacaggcact tttaatgaaa aaggcatcat     1380
 Asp Glu Asn Phe 
 390

 ctaagtttaa aaacaaatga aaagacttag aaattcatga atattgtgat tattttacat   1440

 ttggaaacaa cttctgcaag tttatgtttt atgttttgtg taataacttg cttcctagta   1500

 tgatcagctc atgtacacta tgagagggtt caggggtggg tcatttaaat aatgaattgg   1560

 ctaatgtgga ttttaaattt catatcatga tataagcact gcaatggaaa tgtttttact   1620

 aaaacattat atttttgtgg tactagaatt tcctgaggtg aaaaaccgat attgaagatt   1680

 catttttctt ttttccattc ttcaggacct tcggcaaggt gagtcaaggc tctctaccta   1740

 cctagatgtt tttcagaggc ctacaaatac aagtatcttt cttatatgca cattctaata   1800

 aatgatgaaa ttcagtccaa catgcttatt ataaacatag caattcttgc tctatcaaat   1860

 tagcttatat gccaaatatt aaatatggtt tatttaggta agcataaaaa cataggggct   1920

 atcattttta aagacttgat tttctctatt gtggtaaaat atataaatac atatttgcca   1980

 ttttaaacat ttaccatttt aaccattttt aagtgtacag ttctttcgca ttaatgcacc   2040

 catgaccacc attcacttaa atttttaaaa gaacagtata ttcttttttt cctagagcct   2100

 tcagatgaga gggaacagta tattctattg cacgtctaca attcccaaaa gacctcttac   2160

 tttgggaggc caaggtgggt gggtcacttg aacccaggag tttgacatca acctgggcaa   2220

 catggtgacc tcccgtcttt ctcggaatgt atataaaaat aaaaaaaaaa              2270




      <210> 140
      <211> 1844
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (333)..(1490)

      <400> 140
 gagtgtgtgg gagtgagagt gtgtgggagt ggggtgaggg agaagctgac gggacgcgag     60

 gcggtgagaa actgggcgag tgtgcgagga cgcccggcca gcctgcggga gccgcagtcg    120

 gcggaggaga aaggaggcgg ctcccggtat cccgaccccc tccccctcct cttcttcccc    180

 cacttccagc cgcccggcgg cccgcgcttc ctcgaaggcc ccagcccggc tcagtcggcc    240

 gagagcgagg gaggagcccc ccgacccagg tgagcggtag acgttacatc caagaggaaa    300

 taatccaggc aaggaagcac aagctgatca ag  atg tgt agt tct gtg gct gcc     353
                                      Met Cys Ser Ser Val Ala Ala
                                        1               5

 aag ttg tgg ttt ttg aca gat cgt cgc atc agg gaa gac tat cct caa      401
 Lys Leu Trp Phe Leu Thr Asp Arg Arg Ile Arg Glu Asp Tyr Pro Gln
          10                  15                  20

 aaa gag att tta cga gca ttg aag gcc aaa tgt tgt gag gag gaa ctg      449
 Lys Glu Ile Leu Arg Ala Leu Lys Ala Lys Cys Cys Glu Glu Glu Leu
      25                  30                  35

 gac ttt agg gct gtg gtg atg gat gag gtg gtg ctg aca atc gag caa      497
 Asp Phe Arg Ala Val Val Met Asp Glu Val Val Leu Thr Ile Glu Gln
  40                  45                  50                  55

 gga aac ctg ggt ctg cgg atc aat gga gag cta atc act gcc tac cca      545
 Gly Asn Leu Gly Leu Arg Ile Asn Gly Glu Leu Ile Thr Ala Tyr Pro
                  60                  65                  70

 caa gtg gtg gta gtc aga gta cca acc cct tgg gtg caa agt gat agt      593
 Gln Val Val Val Val Arg Val Pro Thr Pro Trp Val Gln Ser Asp Ser
              75                  80                  85

 gac atc act gtt ttg cgc cat cta gag aag atg gga tgt cgg tta atg      641
 Asp Ile Thr Val Leu Arg His Leu Glu Lys Met Gly Cys Arg Leu Met
          90                  95                 100

 aac cga cct caa gcc atc ctg aac tgc gtt aat aag ttc tgg aca ttt      689
 Asn Arg Pro Gln Ala Ile Leu Asn Cys Val Asn Lys Phe Trp Thr Phe
     105                 110                 115

 caa gag ttg gct ggc cat ggt gtt cct ctg ccg gat act ttc tct tat      737
 Gln Glu Leu Ala Gly His Gly Val Pro Leu Pro Asp Thr Phe Ser Tyr
 120                 125                 130                 135

 ggt ggc cac gaa aat ttt gct aaa atg att gat gag gct gaa gtt ctg      785
 Gly Gly His Glu Asn Phe Ala Lys Met Ile Asp Glu Ala Glu Val Leu
                 140                 145                 150

 gag ttc cca atg gta gta aag aat acg cgg ggt cac aga ggt aaa gct      833
 Glu Phe Pro Met Val Val Lys Asn Thr Arg Gly His Arg Gly Lys Ala
             155                 160                 165

 gtt ttc ttg gct cga gat aag cac cat ttg gct gat cta agc cat ctt      881
 Val Phe Leu Ala Arg Asp Lys His His Leu Ala Asp Leu Ser His Leu
         170                 175                 180

 att cgc cat gaa gcg cca tac ctg ttc cag aag tat gtt aaa gag tct      929
 Ile Arg His Glu Ala Pro Tyr Leu Phe Gln Lys Tyr Val Lys Glu Ser
     185                 190                 195

 cat gga cgg gat gta cgt gtc att gtc gtg gga ggc cgt gtg gtt ggc      977
 His Gly Arg Asp Val Arg Val Ile Val Val Gly Gly Arg Val Val Gly
 200                 205                 210                 215

 acc atg tta cgt tgt tca aca gat ggg aga atg caa agc aac tgc tca     1025
 Thr Met Leu Arg Cys Ser Thr Asp Gly Arg Met Gln Ser Asn Cys Ser
                 220                 225                 230

 tta ggt ggt gtg ggg atg atg tgc tca ttg agt gaa caa ggg aag cag     1073
 Leu Gly Gly Val Gly Met Met Cys Ser Leu Ser Glu Gln Gly Lys Gln
             235                 240                 245

 cta gct atc cag gtg tct aat atc ctg ggg atg gat gtg tgt ggc att     1121
 Leu Ala Ile Gln Val Ser Asn Ile Leu Gly Met Asp Val Cys Gly Ile
         250                 255                 260

 gac ctg ctg atg aaa gat gac ggc tcc ttc tgc gtc tgt gag gcc aat     1169
 Asp Leu Leu Met Lys Asp Asp Gly Ser Phe Cys Val Cys Glu Ala Asn
     265                 270                 275

 gca aat gta ggt ttc atc gcc ttt gat aag gct tgt aat cta gat gta     1217
 Ala Asn Val Gly Phe Ile Ala Phe Asp Lys Ala Cys Asn Leu Asp Val
 280                 285                 290                 295

 gct ggt atc ata gca gac tat gcc gcc tcc ctt cta ccc tct ggc cgg     1265
 Ala Gly Ile Ile Ala Asp Tyr Ala Ala Ser Leu Leu Pro Ser Gly Arg
                 300                 305                 310

 ctc acc cgg cgt atg tcc ctg ctc tcc gtg gtg tcc act gcc agt gag     1313
 Leu Thr Arg Arg Met Ser Leu Leu Ser Val Val Ser Thr Ala Ser Glu
             315                 320                 325

 act agt gag ccg gag ctg ggt ccc cca gcc agc act gct gtt gac aac     1361
 Thr Ser Glu Pro Glu Leu Gly Pro Pro Ala Ser Thr Ala Val Asp Asn
         330                 335                 340

 atg agt gca agt tcc agc tct gtt gac agc gac cct gaa agc acg gag     1409
 Met Ser Ala Ser Ser Ser Ser Val Asp Ser Asp Pro Glu Ser Thr Glu
     345                 350                 355

 cga gag ctg ctc acc aag ctc cca ggg ggc ctg ttc aac atg aac cag     1457
 Arg Glu Leu Leu Thr Lys Leu Pro Gly Gly Leu Phe Asn Met Asn Gln
 360                 365                 370                 375

 ctg cta gcc aat gaa atc aaa cta ctg gtg gac tgactcca ctggtaatta     1508
 Leu Leu Ala Asn Glu Ile Lys Leu Leu Val Asp 
                 380                 385

 accaacaaaa cccttgtaaa actttctttc ttcttttcta tttttaaaac caacttgcaa   1568

 tgctgttcat ggaggatgct caggaagatg agagaaaatt agtaggatta gttggagaga   1628

 gtgggagata gatgagacct ctgctagtaa gatgttactt tcatttacaa atcctacaaa   1688

 tagagaggca gaataggtgg ggtatagaaa aatgtcaggc tctcatagtt acccttttaa   1748

 attgctaaaa aatgtgtatg ctcataggcc atgaggaaca aatacttttt ttttttcatg   1808

 gtcccttgct tttgtttttg tacaaaaaaa aaaaaa                             1844




      <210> 141
      <211> 456
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (14)..(136)

      <400> 141
 ttccggcacc acc   atg tcg aag gtt tcc ttt aag atc acg ctg acg tcg      49
                  Met Ser Lys Val Ser Phe Lys Ile Thr Leu Thr Ser
                    1               5                  10

 gac cca cgg ctg ccg tac aaa gta ctc agt gtt cct gaa agt aca cct       97
 Asp Pro Arg Leu Pro Tyr Lys Val Leu Ser Val Pro Glu Ser Thr Pro
          15                  20                  25

 ttc aca gca gtc tta aag ttt gca gca gaa gaa atg gaa taggaataaa       146
 Phe Thr Ala Val Leu Lys Phe Ala Ala Glu Glu Met Glu 
      30                  35                  40

 tcctgcacag actgctggaa atgtttttct aaaacatggt tcagaactgc ggattattcc    206

 tagagatcgt gttggaagtt gttaatatct gctacttgga acatacgatt gcctttcaga    266

 ataaatattg gtattttttg ttgttgtaaa attgaaatca ggcatttaac atactatgaa    326

 aacaccagga gtcaatgatt aatgaaaggt gactcatctg tccctatttg atgtccatat    386

 tcttcttata aaagggattc ctatataatt aagggttcta atgggcccaa aaaaaaaatc    446

 tttttgggct                                                           456




      <210> 142
      <211> 1519
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (84)..(968)

      <400> 142
 aaacagttgc cttttcctct cacagaagga agatttcatt ttgtttgaga cgagaaacca     60

 aaccacacac caaagagagg ggt    atg atg gct aag aag ccc cca aaa cca     110
                              Met Met Ala Lys Lys Pro Pro Lys Pro
                                1               5

 gcc cct cgc agg atc ttc cag gaa agg tta aag att act gct cta cct      158
 Ala Pro Arg Arg Ile Phe Gln Glu Arg Leu Lys Ile Thr Ala Leu Pro
  10                  15                  20                  25

 ttg tac ttt gaa ggt ttt tta tta atc aag cgg tca gga tac cgg gag      206
 Leu Tyr Phe Glu Gly Phe Leu Leu Ile Lys Arg Ser Gly Tyr Arg Glu
                  30                  35                  40

 tat gag cat tac tgg aca gag ttg aga gga act act ctt ttc ttt tat      254
 Tyr Glu His Tyr Trp Thr Glu Leu Arg Gly Thr Thr Leu Phe Phe Tyr
              45                  50                  55

 acc gac aaa aag agt ata ata tat gtt gac aaa tta gac ata gta gac      302
 Thr Asp Lys Lys Ser Ile Ile Tyr Val Asp Lys Leu Asp Ile Val Asp
          60                  65                  70

 ctc aca tgc ctt act gag cag aat tca act gaa aag aac tgt gcg aaa      350
 Leu Thr Cys Leu Thr Glu Gln Asn Ser Thr Glu Lys Asn Cys Ala Lys
      75                  80                  85

 ttc acc ctt gtt ttg ccg aaa gag gaa gta caa ctg aag aca gag aac      398
 Phe Thr Leu Val Leu Pro Lys Glu Glu Val Gln Leu Lys Thr Glu Asn
  90                  95                 100                 105

 aca gaa agt ggg gaa gaa tgg aga ggc ttc att ctt acg gta aca gag      446
 Thr Glu Ser Gly Glu Glu Trp Arg Gly Phe Ile Leu Thr Val Thr Glu
                 110                 115                 120

 ctg tca gtt ccc caa aac gtg tca ctc cta cct ggg caa gta att aaa      494
 Leu Ser Val Pro Gln Asn Val Ser Leu Leu Pro Gly Gln Val Ile Lys
             125                 130                 135

 ctg cat gaa gtc cta gag aga gaa aaa aaa agg agg att gag aca gag      542
 Leu His Glu Val Leu Glu Arg Glu Lys Lys Arg Arg Ile Glu Thr Glu
         140                 145                 150

 cag agt acg tcc gtg gaa aaa gag aag gaa cca act gaa gat tat gtg      590
 Gln Ser Thr Ser Val Glu Lys Glu Lys Glu Pro Thr Glu Asp Tyr Val
     155                 160                 165

 gat gta ctg aac cct atg cca gca tgt ttt tat aca gtg tcc cgg aaa      638
 Asp Val Leu Asn Pro Met Pro Ala Cys Phe Tyr Thr Val Ser Arg Lys
 170                 175                 180                 185

 gag gca act gag atg ctc cag aag aac cct tct ttg gga aat atg atc      686
 Glu Ala Thr Glu Met Leu Gln Lys Asn Pro Ser Leu Gly Asn Met Ile
                 190                 195                 200

 ctg agg cct ggt agt gac agt aga aac tac tcc atc act att cgg cag      734
 Leu Arg Pro Gly Ser Asp Ser Arg Asn Tyr Ser Ile Thr Ile Arg Gln
             205                 210                 215

 gag ata gac att cca aga atc aag cac tac aaa gtg atg agc gta gga      782
 Glu Ile Asp Ile Pro Arg Ile Lys His Tyr Lys Val Met Ser Val Gly
         220                 225                 230

 caa aac tac act att gaa ctg gaa aaa cct gta aca ctc cca aac ctt      830
 Gln Asn Tyr Thr Ile Glu Leu Glu Lys Pro Val Thr Leu Pro Asn Leu
     235                 240                 245

 ttc agt gtc att gat tat ttt gtg aag gag act cga gga aat tta aga      878
 Phe Ser Val Ile Asp Tyr Phe Val Lys Glu Thr Arg Gly Asn Leu Arg
 250                 255                 260                 265

 cca ttt ata tgt tca act gat gaa aac act ggt caa gaa ccc agt atg      926
 Pro Phe Ile Cys Ser Thr Asp Glu Asn Thr Gly Gln Glu Pro Ser Met
                 270                 275                 280

 gaa ggg aga agt gaa aag ttg aag aaa aat cca cac att gca tgaaata      975
 Glu Gly Arg Ser Glu Lys Leu Lys Lys Asn Pro His Ile Ala 
             285                 290                 295

 caatgtgaaa gctcctttgt atatcttggt aatttatatt ttcaaaacga agttcttact   1035

 tttaaagaga attacctata ttctcctgat actgattacc aagtcattca cctgaacacc   1095

 agaattagaa ttaaacattg taccatacaa tttcattatc ttatcagaat gaaaccaatt   1155

 cacagggaaa ctagagacta cggctgtggt ggtaacctgc agatatacac attcccatgc   1215

 actgacataa gttgaaaaca catagtactt tctagatgga atttttttct ttaggcctca   1275

 atgaaataca tttcccctat ataattccaa cagcagtttc tctagttcta aattttacca   1335

 attcccaaaa aacctaagtt ttgctgaaat ctgatttgac caatttatca aatatgtcat   1395

 tttaattacc tagctggaag ttagagacat gaaatgtact agaggagccc ttttccaatg   1455

 gaaatattat ataccacatt ttttgttaat ggaaataaat gtctccattc ccaaaaaaaa   1515

 aaaa                                                                1519




      <210> 143
      <211> 4958
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2301)

      <400> 143
  atg gcc cgc ggg tcg ctg ggg gtc agc ccc cgg gcc ccc ctc gct gcg      48
  Met Ala Arg Gly Ser Leu Gly Val Ser Pro Arg Ala Pro Leu Ala Ala
    1               5                  10                  15

 ccc cgc ttt agc cag tgt gga atg tgg cgt gtc tgc gcg ttc caa acc       96
 Pro Arg Phe Ser Gln Cys Gly Met Trp Arg Val Cys Ala Phe Gln Thr
              20                  25                  30

 cgc tct cgc ctg gaa tgt tgc gtg tgc ctg cgt tcc gag ccc gtt ggt      144
 Arg Ser Arg Leu Glu Cys Cys Val Cys Leu Arg Ser Glu Pro Val Gly
          35                  40                  45

 tac acc gga agt gat ggg cgg gga cat cgc cca cac tcc ccg gct gtt      192
 Tyr Thr Gly Ser Asp Gly Arg Gly His Arg Pro His Ser Pro Ala Val
      50                  55                  60

 gcc ttg atg gtc cag agc agg gtc tgg cag tgg aga gtg ccc ctg gtg      240
 Ala Leu Met Val Gln Ser Arg Val Trp Gln Trp Arg Val Pro Leu Val
  65                  70                  75                  80

 acc aag aat gtc cta cgt ttg ggc aca ggg gtc agg gga aga ccg tgc      288
 Thr Lys Asn Val Leu Arg Leu Gly Thr Gly Val Arg Gly Arg Pro Cys
                  85                  90                  95

 aca agg ttc gga gag att aag tca cct gct gcc gcc atc aac acg ttg      336
 Thr Arg Phe Gly Glu Ile Lys Ser Pro Ala Ala Ala Ile Asn Thr Leu
             100                 105                 110

 cag ttc gag tac gca ctg tgt tta ggc cga gtt cag cgg cct ggt cac      384
 Gln Phe Glu Tyr Ala Leu Cys Leu Gly Arg Val Gln Arg Pro Gly His
         115                 120                 125

 gac ttc tgt gtg ccg gct gag cgg ggt gtc act gag gat gtc aga gga      432
 Asp Phe Cys Val Pro Ala Glu Arg Gly Val Thr Glu Asp Val Arg Gly
     130                 135                 140

 tgc ttt agg cct gaa gga cag gac atg ctg gcg ctg ctg ctg gtg ggc      480
 Cys Phe Arg Pro Glu Gly Gln Asp Met Leu Ala Leu Leu Leu Val Gly
 145                 150                 155                 160

 cgc ctg tcc tgc ccg cag ccc gga ctg tca gcc ccc gtg act gtc agc      528
 Arg Leu Ser Cys Pro Gln Pro Gly Leu Ser Ala Pro Val Thr Val Ser
                 165                 170                 175

 ccc cgt gac tgt cct act att ccc tgg tgg cgg gga aca ggt ctg ctt      576
 Pro Arg Asp Cys Pro Thr Ile Pro Trp Trp Arg Gly Thr Gly Leu Leu
             180                 185                 190

 gat ttg ttc act gct gtg ccc ccg gca ctt tcc ccc gtg cct ggc tgg      624
 Asp Leu Phe Thr Ala Val Pro Pro Ala Leu Ser Pro Val Pro Gly Trp
         195                 200                 205

 gct gag gag cag gag cgg ctt cgc ttg gag cag gag cga gag cag gaa      672
 Ala Glu Glu Gln Glu Arg Leu Arg Leu Glu Gln Glu Arg Glu Gln Glu
     210                 215                 220

 cag aag aag gcc aat agc ctg gcc agg ctg gca cat acc ctt cct gtg      720
 Gln Lys Lys Ala Asn Ser Leu Ala Arg Leu Ala His Thr Leu Pro Val
 225                 230                 235                 240

 gag gaa ccc cgc atg gag gcg cca ccc ctg cct ctg tct cca ccg gct      768
 Glu Glu Pro Arg Met Glu Ala Pro Pro Leu Pro Leu Ser Pro Pro Ala
                 245                 250                 255

 ccc ccg ccg gca ccc cca cca cca ctt gcc acc cct gcc cca ctg act      816
 Pro Pro Pro Ala Pro Pro Pro Pro Leu Ala Thr Pro Ala Pro Leu Thr
             260                 265                 270

 gtc atc cct atc cct gtg gtg acc aac tcc cct cag cct cta ccc cca      864
 Val Ile Pro Ile Pro Val Val Thr Asn Ser Pro Gln Pro Leu Pro Pro
         275                 280                 285

 ccc cca ccc ttg ccc gcg gca gcc cag cct ctg ccc ctg gcg cct cgt      912
 Pro Pro Pro Leu Pro Ala Ala Ala Gln Pro Leu Pro Leu Ala Pro Arg
     290                 295                 300

 cag ccg gcc ctg gtt ggc gcc ccc gga ctc agc att aag gag cct gcc      960
 Gln Pro Ala Leu Val Gly Ala Pro Gly Leu Ser Ile Lys Glu Pro Ala
 305                 310                 315                 320

 ccc ctg ccc agc agg ccg cag gtg ccc acc cct gct ccc cta ctg ccg     1008
 Pro Leu Pro Ser Arg Pro Gln Val Pro Thr Pro Ala Pro Leu Leu Pro
                 325                 330                 335

 gac tcg aag gcc acc att cca ccc aat ggc agc ccc aag cct ttg cag     1056
 Asp Ser Lys Ala Thr Ile Pro Pro Asn Gly Ser Pro Lys Pro Leu Gln
             340                 345                 350

 ccc ctc ccc acg cct gtc ctg acc ata gcg cca cac cct gga gtc cag     1104
 Pro Leu Pro Thr Pro Val Leu Thr Ile Ala Pro His Pro Gly Val Gln
         355                 360                 365

 cct cag ctg gcc ccc cag cag ccg ccc cca ccc acg ctg ggg acc ctg     1152
 Pro Gln Leu Ala Pro Gln Gln Pro Pro Pro Pro Thr Leu Gly Thr Leu
     370                 375                 380

 aag ttg gca cca gct gaa gaa gtc aaa tcc agt gaa cag aag aag agg     1200
 Lys Leu Ala Pro Ala Glu Glu Val Lys Ser Ser Glu Gln Lys Lys Arg
 385                 390                 395                 400

 ccc ggg ggg atc gga acc aga gaa gtc cac aac aaa ttg gag aag aac     1248
 Pro Gly Gly Ile Gly Thr Arg Glu Val His Asn Lys Leu Glu Lys Asn
                 405                 410                 415

 agg agg gcc cat ctg aaa gag tgc ttt gag acc ctg aag cgg aac atc     1296
 Arg Arg Ala His Leu Lys Glu Cys Phe Glu Thr Leu Lys Arg Asn Ile
             420                 425                 430

 ccc aac gtg gat gac aag aag acg tcc aat ctg agc gtg ctg cgg acg     1344
 Pro Asn Val Asp Asp Lys Lys Thr Ser Asn Leu Ser Val Leu Arg Thr
         435                 440                 445

 gcg ctg cgg tac atc cag tcc ctg aag agg aag gag aag gaa tat gag     1392
 Ala Leu Arg Tyr Ile Gln Ser Leu Lys Arg Lys Glu Lys Glu Tyr Glu
     450                 455                 460

 cat gaa atg gag cgg ctg gca cgt gag aag att gcc acg cag cag cgg     1440
 His Glu Met Glu Arg Leu Ala Arg Glu Lys Ile Ala Thr Gln Gln Arg
 465                 470                 475                 480

 ctg gca gag ctc aag cac gag ctg agc cag tgg atg gac gta ctg gag     1488
 Leu Ala Glu Leu Lys His Glu Leu Ser Gln Trp Met Asp Val Leu Glu
                 485                 490                 495

 att gac cgc gtg ctg cgg cag acg ggc cag ccc gag gat gac cag gcc     1536
 Ile Asp Arg Val Leu Arg Gln Thr Gly Gln Pro Glu Asp Asp Gln Ala
             500                 505                 510

 tcc acc tcc acc gcc tct gag ggt gag gac aac ata gac gag gat atg     1584
 Ser Thr Ser Thr Ala Ser Glu Gly Glu Asp Asn Ile Asp Glu Asp Met
         515                 520                 525

 gag gag gac cgg gcg ggc ctg ggc cca cct aag ctg agc cat cgt ccc     1632
 Glu Glu Asp Arg Ala Gly Leu Gly Pro Pro Lys Leu Ser His Arg Pro
     530                 535                 540

 cag ccg gag ctg ctg aag tcc acc ctg cca ccc ccc agc acc acc cct     1680
 Gln Pro Glu Leu Leu Lys Ser Thr Leu Pro Pro Pro Ser Thr Thr Pro
 545                 550                 555                 560

 gcg cct ctg cct cca cac cca cac cct cac ccc cac tcc gtg gcc cta     1728
 Ala Pro Leu Pro Pro His Pro His Pro His Pro His Ser Val Ala Leu
                 565                 570                 575

 cct cct gcc cac ctc ccc gtg cag cag cag cag cca cag cag aag acc     1776
 Pro Pro Ala His Leu Pro Val Gln Gln Gln Gln Pro Gln Gln Lys Thr
             580                 585                 590

 cct ctg cca gcc cct cct ccc cca ccg gct gcc cct gcc cag aca ctg     1824
 Pro Leu Pro Ala Pro Pro Pro Pro Pro Ala Ala Pro Ala Gln Thr Leu
         595                 600                 605

 gtg cca gct cca gcc cat ctg gtg gcg acg gct ggg ggt ggc tcc acg     1872
 Val Pro Ala Pro Ala His Leu Val Ala Thr Ala Gly Gly Gly Ser Thr
     610                 615                 620

 gtc atc gcc cac aca gcc acc act cac gct tca gtc atc cag act gtg     1920
 Val Ile Ala His Thr Ala Thr Thr His Ala Ser Val Ile Gln Thr Val
 625                 630                 635                 640

 aac cac gtt ctg cag ggg cca ggc ggc aag cac atc gcc cac atc gcc     1968
 Asn His Val Leu Gln Gly Pro Gly Gly Lys His Ile Ala His Ile Ala
                 645                 650                 655

 ccc tcg gcc ccc agc cct gcg gtg caa ctg gcg cct gcc aca ccc ccc     2016
 Pro Ser Ala Pro Ser Pro Ala Val Gln Leu Ala Pro Ala Thr Pro Pro
             660                 665                 670

 att ggg cac atc act gtg cac cct gcc acc ctc aac cat gtg gcc cac     2064
 Ile Gly His Ile Thr Val His Pro Ala Thr Leu Asn His Val Ala His
         675                 680                 685

 ctg ggc tcc cag ctg ccc ttg tac ccg cag ccc gtg gca gtg agc cac     2112
 Leu Gly Ser Gln Leu Pro Leu Tyr Pro Gln Pro Val Ala Val Ser His
     690                 695                 700

 atc gcc cac acc ctc tcg cac cag caa gtc aac ggc acg gcc ggc ctg     2160
 Ile Ala His Thr Leu Ser His Gln Gln Val Asn Gly Thr Ala Gly Leu
 705                 710                 715                 720

 ggg ccc ccg gct act gtc atg gca aag ccg gcc gtg ggg gct cag gtg     2208
 Gly Pro Pro Ala Thr Val Met Ala Lys Pro Ala Val Gly Ala Gln Val
                 725                 730                 735

 gtg cac cac ccc cag ctg gtg ggc cag acc gtg ctc aac cct gtg acc     2256
 Val His His Pro Gln Leu Val Gly Gln Thr Val Leu Asn Pro Val Thr
             740                 745                 750

 atg gtc acc atg ccc tcc ttc cca gtc agc aca ctc aag ctg gct tga     2304
 Met Val Thr Met Pro Ser Phe Pro Val Ser Thr Leu Lys Leu Ala 
         755                 760                 765

 ggacgaggcc actcagaggc ccccagtggg gacagggagg gggacctgtc ccccactctc   2364

 tcacccacca gctccacaca ttccagccag gcccaggcca gcccccccac ccacccccag   2424

 gcctcctagg ggaagggggt gcaaagactc tgagccaagg gagggaaggg ccaccctgct   2484

 gcgctaggac ttggtaagat gactctgaga aaatgcgaga ctctgatgga atgtgccacc   2544

 tgtccggccc agtgccagct ccagtgccgc tcctgcttcc cctccctacc ctcggaaatc   2604

 agtgcgatgt ggacgtcacg ctccctgact tctcccccgc cctgccccgc cttcgtgtgc   2664

 tgctgctgct attgctgtct ggtgaggtgg cccaggcccc cggctttcct ccggagcctc   2724

 atgttctctt cccaggcctt tggaggggaa atggggaaag cagaactgaa gccacttggc   2784

 ccagaaagct gcggattggg gtgataaggg gccttgctct gagcacaggt gacagatcat   2844

 aggaagtggc tggtctggag tcccacccgg acaggtgggg cctcagcctg gggctctctg   2904

 acccggttgc agtcactgtg attcgttacc gtagatacta cttaaaatga ttctctacca   2964

 acaataaacc aaacccagcc actgccaagc ttcctgtgcc ctcaccccaa tccctgccac   3024

 tgggctctgg acctcaggag ggcaggctga ggtggggaag gagggacttg gctgtccttc   3084

 cccttccccg tcccctgcag cctgggtctg gatgggagga gagccactgg gcccctgtcc   3144

 ccagtcccca gtccccagcc ctgggcttgg ctcttggctt ccagaaggca gcaaagaggg   3204

 gcgctgtcct gcgttcagcc cctgatctct gacctctgct gagtgctggg cactgctcca   3264

 agggacaggt gggcctggcg gcctgtgggt ttgggtgcct cctgcagttt gggagacatg   3324

 gaccagcatc tggtcttgtt tccaggagca tagaagccac atcgttgaga catcaggaag   3384

 gtaaaaaccc agcggcttag ccaagcccta agcctgtccc cagaccaacc ctgggaccta   3444

 tacagaacag agggccagag ctagggctgc tgcttctgct ccagcccctt tgcctctgtc   3504

 ctcccatccc ctcaacaccc tgcttctccc ggggacgctt ttgagtgggc cctgcccggg   3564

 gagctgcaga gcagcagcac ctttctctga gaagaggtcc ttggttgggt caaggacagg   3624

 gctgagcgtg gaagggggag gagtcagggg ctctgtgtta ggatgcggct ttctctgcct   3684

 ctgggcagcc tgctttggcc tttccttgta tgtgggtgtt tattacaagt gggccccccc   3744

 cccctcccca cctggacaca cacacaccag tggccttcag tgtagcggga ggaagccggt   3804

 gtccctggat gtgaagctca cactgatggg ctggggcagg ggctgggcgg cgagggggcc   3864

 cggggagggg acagagctga ggatttcctg gagtgccctg caggccaaga ggaggtcagc   3924

 aaaggtcttg aatagatttt ctctggaaat aaagaatcct tagatcctaa aaatcccttc   3984

 ctgttccctc ctggtcctgg acacctccca ggggactgtt ccttatttct ctctcctggt   4044

 gtgggtaaag ggacagttac aaaccaggtc accatcctca gaggctgagc ctgtacccac   4104

 cccagcacag ccacctgcca gacccgtggc tctgggagag agcccttttg ctattccatt   4164

 gtgacagcga tgcaggcctg accggacggg gcagttagag cagcctcgtg gagctcgccc   4224

 ctcccctcag cctgcccgcc tctccctgca tcctgagcca gtgcccccgg gcctgcacag   4284

 atacctcatc atccacccgc tgcccctccc cgtccctgtc cccagcatcg ggggcctgca   4344

 aatctagtgc cgaaatctag tgccgaatga ctatgtccag attggtgacg atgggtgttg   4404

 ctgtttttct tgtgtttgtg aacgcatgtg atgctgtgga agtgggcagt caccacccag   4464

 cccttccttg ggcgtctccc ccagagtgct gtcgggacca catctgtcct cacctgtggg   4524

 agcgcctggc cctccctccc tagcccttcc agcctgggac acacacacac acacacacac   4584

 acacacacac acacacgcac gcacacgcac acatcttacc tctcatgcgt gttttacctt   4644

 ttgatgttca gagtggctca ctggctggga gtccttacct cggggaggag ggggaggttg   4704

 gttccttggg gggccaaaga aggcagggaa tgcctggagg gtaactgggg ggccaccatg   4764

 accccttctc tctccagaaa cagctgcttc tccccccatc ccagggtccc acccccaacc   4824

 cccagaggtg gcccttgttt acagtgagga ctcggccact gtgtctctgt ttcctgaaat   4884

 ataaactgta gcgaccccag actgtagaga tttttatgtg tttggataca tctgctgtgt   4944

 ggaaaaaaaa aaaa                                                     4958




      <210> 144
      <211> 974
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (234)..(440)

      <400> 144
 agccaggggc ccatttgggg gcccagcccc caatcccacc cagcagagga agccaaggtc     60

 ggggcagctg tgattgctcc ctggtcctgg agaggaaact ggccatctgc tttatctgaa    120

 gattttcagc tgatgaagaa ctaggaggct caaacactat cttacctgag tccaggacaa    180

 gtgacttgga gagtgtgctc ttctgtggca ggatcaggtc tgtctagggc agg   atg     236
                                                              Met
                                                                1

 gcc cag gat ctc agc gag aag gac ctg ttg aag atg gag gtg gag cag      284
 Ala Gln Asp Leu Ser Glu Lys Asp Leu Leu Lys Met Glu Val Glu Gln
               5                  10                  15

 ctg aag aaa gaa gtg aaa aac aca aga att ccg att tcc aaa gcg gga      332
 Leu Lys Lys Glu Val Lys Asn Thr Arg Ile Pro Ile Ser Lys Ala Gly
          20                  25                  30

 aag gaa atc aag gag tac gtg gag gcc caa gca gga aac gat cct ttt      380
 Lys Glu Ile Lys Glu Tyr Val Glu Ala Gln Ala Gly Asn Asp Pro Phe
      35                  40                  45

 ctc aaa ggc atc cct gag gac aag aat ccc ttc aag gag aaa ggt ggc      428
 Leu Lys Gly Ile Pro Glu Asp Lys Asn Pro Phe Lys Glu Lys Gly Gly
  50                  55                  60                  65

 tgt ctg ata agc tga tggcatggag ccctgccctg agtgtctgtc cctcttcagc      483
 Cys Leu Ile Ser 


 caagcccaag tctcctagac ccccagggag ccagtgaact gtcaccttct cttcatcaca    543

 gaatgagtaa agatccctga acaaatgcat tgtgaaccca ttccccactc ccaccttcaa    603

 ctcttttctc ccattatttc ctccacctgc tgggtctctg ctgaccttgc tgggaacact    663

 ctgaggacag tgtggctggc cgagcggttg gccccatggg tggtggggtg tgagaagcct    723

 gcaatacccc aagaccccag agggcagtcc ttaggaagca cttacaccac ctgggaaccc    783

 ctccgtcttt tccctctact ctcatcctag gaataaagca tttccacgcc agagtagttt    843

 gggctggggg ccagggttgg gtggtcctgt ccctccatat catgtcctac cctatggtcc    903

 tgttcctagt catttagatc accccagatg gcctgatgac aacaagagtt tgtgaagtta    963

 aaaaaaaaaa a                                                         974




      <210> 145
      <211> 4144
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (373)..(1626)

      <400> 145
 tcaagctcgc cccgcgcagc ccgagccggg ctgggcgctg tcctcggggg cctggggaac     60

 cgcgcggttt ggagatcgga ggcacctgga acccgtggca agcgccgagc cgggagacag    120

 cccgaggaac cacgggttct ggagctagga gccggaagct gggagtccgg aggagagcgg    180

 agcccggagc ccggagcccg gggcggcgcg tctgggtctg gcgcttcccg actggacggc    240

 gcgcccgctg gtcttcgcca cgcgccctcc cctgggctcg cgttcatcgg tccccgcctg    300

 agacgcgccc actcctgccc ggacttccag ccccggaggc gccggacaga gccgcggact    360

 ccagcgccca cc    atg cgc ctc aac agc tcc gcg ccg gga acc ccg ggc     408
                  Met Arg Leu Asn Ser Ser Ala Pro Gly Thr Pro Gly
                    1               5                  10

 acg ccg gcc gcc gac ccc ttc cag cgg gcg cag gcc gga ctg gag gag      456
 Thr Pro Ala Ala Asp Pro Phe Gln Arg Ala Gln Ala Gly Leu Glu Glu
          15                  20                  25

 gcg ctg ctg gcc ccg ggc ttc ggc aac gct tcg ggc aac gcg tcg gag      504
 Ala Leu Leu Ala Pro Gly Phe Gly Asn Ala Ser Gly Asn Ala Ser Glu
      30                  35                  40

 cgc gtc ctg gcg gca ccc agc agc gag ctg gac gtg aac acc gac atc      552
 Arg Val Leu Ala Ala Pro Ser Ser Glu Leu Asp Val Asn Thr Asp Ile
  45                  50                  55                  60

 tac tcc aaa gtg ctg gtg acc gcc gtg tac ctg gcg ctc ttc gtg gtg      600
 Tyr Ser Lys Val Leu Val Thr Ala Val Tyr Leu Ala Leu Phe Val Val
                  65                  70                  75

 ggc acg gtg ggc aac acg gtg acg gcg ttc acg ctg gcg cgg aag aag      648
 Gly Thr Val Gly Asn Thr Val Thr Ala Phe Thr Leu Ala Arg Lys Lys
              80                  85                  90

 tcg ctg cag agc ctg cag agc acg gtg cat tac cac ctg ggc agc ctg      696
 Ser Leu Gln Ser Leu Gln Ser Thr Val His Tyr His Leu Gly Ser Leu
          95                 100                 105

 gcg ctg tcc gac ctg ctc acc ctg ctg ctg gcc atg ccc gtg gag ctg      744
 Ala Leu Ser Asp Leu Leu Thr Leu Leu Leu Ala Met Pro Val Glu Leu
     110                 115                 120

 tac aac ttc atc tgg gtg cac cac ccc tgg gcc ttc ggc gac gcc ggc      792
 Tyr Asn Phe Ile Trp Val His His Pro Trp Ala Phe Gly Asp Ala Gly
 125                 130                 135                 140

 tgc cgc ggc tac tac ttc ctg cgc gac gcc tgc acc tac gcc acg gcc      840
 Cys Arg Gly Tyr Tyr Phe Leu Arg Asp Ala Cys Thr Tyr Ala Thr Ala
                 145                 150                 155

 ctc aac gtg gcc agc ctg agt gtg gag cgc tac ctg gcc atc tgc cac      888
 Leu Asn Val Ala Ser Leu Ser Val Glu Arg Tyr Leu Ala Ile Cys His
             160                 165                 170

 ccc ttc aag gcc aag acc ctc atg tcc cga agc cgc acc aag aag ttc      936
 Pro Phe Lys Ala Lys Thr Leu Met Ser Arg Ser Arg Thr Lys Lys Phe
         175                 180                 185

 atc agc gcc atc tgg ctc gcc tcg gcc ctg ctg acg gtg cct atg ctg      984
 Ile Ser Ala Ile Trp Leu Ala Ser Ala Leu Leu Thr Val Pro Met Leu
     190                 195                 200

 ttc acc atg ggc gag cag aac cgc agc gcc gac ggc cag cac gcc ggc     1032
 Phe Thr Met Gly Glu Gln Asn Arg Ser Ala Asp Gly Gln His Ala Gly
 205                 210                 215                 220

 ggc ctg gtg tgc acc ccc acc atc cac act gcc acc gtc aag gtc gtc     1080
 Gly Leu Val Cys Thr Pro Thr Ile His Thr Ala Thr Val Lys Val Val
                 225                 230                 235

 ata cag gtc aac acc ttc atg tcc ttc ata ttc ccc atg gtg gtc atc     1128
 Ile Gln Val Asn Thr Phe Met Ser Phe Ile Phe Pro Met Val Val Ile
             240                 245                 250

 tcg gtc ctg aac acc atc atc gcc aac aag ctg acc gtc atg gta cgc     1176
 Ser Val Leu Asn Thr Ile Ile Ala Asn Lys Leu Thr Val Met Val Arg
         255                 260                 265

 cag gcg gcc gag cag ggc caa gtg tgc acg gtc ggg ggc gag cac agc     1224
 Gln Ala Ala Glu Gln Gly Gln Val Cys Thr Val Gly Gly Glu His Ser
     270                 275                 280

 aca ttc agc atg gcc atc gag cct ggc agg gtc cag gcc ctg cgg cac     1272
 Thr Phe Ser Met Ala Ile Glu Pro Gly Arg Val Gln Ala Leu Arg His
 285                 290                 295                 300

 ggc gtg cgc gtc cta cgt gca gtg gtc atc gcc ttt gtg gtc tgc tgg     1320
 Gly Val Arg Val Leu Arg Ala Val Val Ile Ala Phe Val Val Cys Trp
                 305                 310                 315

 ctg ccc tac cac gtg cgg cgc ctc atg ttc tgc tac atc tcg gat gag     1368
 Leu Pro Tyr His Val Arg Arg Leu Met Phe Cys Tyr Ile Ser Asp Glu
             320                 325                 330

 cag tgg act ccg ttc ctc tat gac ttc tac cac tac ttc tac atg gtg     1416
 Gln Trp Thr Pro Phe Leu Tyr Asp Phe Tyr His Tyr Phe Tyr Met Val
         335                 340                 345

 acc aac gca ctc ttc tac gtc agc tcc acc atc aac ccc atc ctg tac     1464
 Thr Asn Ala Leu Phe Tyr Val Ser Ser Thr Ile Asn Pro Ile Leu Tyr
     350                 355                 360

 aac ctc gtc tct gcc aac ttc cgc cac atc ttc ctg gcc aca ctg gcc     1512
 Asn Leu Val Ser Ala Asn Phe Arg His Ile Phe Leu Ala Thr Leu Ala
 365                 370                 375                 380

 tgc ctc tgc ccg gtg tgg cgg cgc agg agg aag agg cca gcc ttc tcg     1560
 Cys Leu Cys Pro Val Trp Arg Arg Arg Arg Lys Arg Pro Ala Phe Ser
                 385                 390                 395

 agg aag gcc gac agc gtg tcc agc aac cac acc ctc tcc agc aat gcc     1608
 Arg Lys Ala Asp Ser Val Ser Ser Asn His Thr Leu Ser Ser Asn Ala
             400                 405                 410

 acc cgc gag acg ctg tac taggct gtgcgccccg gaacgtgtcc aggaggagcc     1662
 Thr Arg Glu Thr Leu Tyr 
         415

 tggccatggg tccttgcccc cgacagacag agcagccccc acccgggagc cttgatgggg   1722

 gtcaggcaga ggccagcctg cactggagtc tgaggcctgg gacccccccc tcccaccccc   1782

 taacccatgt ttctcattag tgtctcccgg gcctgtcccc aactcctccc cacccctccc   1842

 ccatctcctc tttgaaagcc agaacaagag agcgctcctc tcccagatag gaaaagggcc   1902

 tctaacaagg agaaattagt gtgcggcaaa aggcagtttt ctttgttctc agactaatgg   1962

 atggttccag agaaggaaat gaaatgtgct gggtggggcc gggcctccgg cggcccggct   2022

 gctgttccca tgtccacatc tctgaggcct gcaccccctc tgtctagctc ggggagtcca   2082

 gccccagtcc cgcaggctcc gtggctttgg gcctcacgtg cagaccctgc catgcagacc   2142

 catgcccccc tcccccaggc agctccaaga aagctccctg actcgcccct tcaggcctgg   2202

 caagctgggg gcccatcgcc gtggggagtc cctcccacca ccctcgccgc aggcagctgc   2262

 agcccccaga ggggaccaca agcccaaaaa ggacaaaaat gggctggcct ggaatggccc   2322

 agaccccagc ctcccctcct ccctcccatc ctcacccagg ccaaggccca ggggctctgc   2382

 caggacacca catgggaggg ggctcaggcc tcagcctcaa gatcttcagc tgtggcctct   2442

 cgggctcggc agaagggacg ccggatcagg ggcctggtct ccagcacctg cccgagtggc   2502

 cgtggccagg atggggtgcg cattccgtgt gctttgcttg tagctgtgca ggctgaggtc   2562

 tggagccagg cccagagctg gcttcagggt ggggccttga gaaggggaat gtgggacagg   2622

 ggcgatggtg cctggtctct gagtaagatg ccaggtccca ggaactcagg cttcaggtga   2682

 gaaggagcgg tgtgtccagg caccgctggc cggcagccct gggctgaggc acagactcat   2742

 ttgtcacctt ctggcggcgg cagccctggc cccggcctcc aagcagttga aaaagctggc   2802

 gcctccttgg tctctaggat ccaggctcca cagagcacat gactagccag gcccctggct   2862

 taagaaggtc gcctaagcct aagagaagac agtcccagga gaagctggcc gggaccagcc   2922

 aggagctggg agccacagga agcaaaagtc agccttttct tcaagggatt tccctgtctc   2982

 agagcagcct ttgccccagg gaaatgggct ctgggctggc tgcctgcacc ggccatgtcg   3042

 acccaggacc cggacacctg gtcttgggct gtgttcagcc actttgcctt ctctggactc   3102

 agtttccccg tctgagaaat gagagtcgaa tgctacagta tctgcagtcg cttggatctg   3162

 gctgttgagt tgacgggttc cttgaacccc acaaaatccc tctccaacca caggaccctt   3222

 cggctcacca agaacggggc ccaggggagt caggcctatt cgctgcactt cctgccaaac   3282

 tttgccccca caagcctggt catcagccag gcagccctcc cagtgcccaa gggccaccaa   3342

 ccccagggaa acagggccag cacagagggg ccttcctccc ccacagagct cccatgacat   3402

 agtctgctct gggcggaaga gctttgctgc cagccaggga tgtccagagg tcggtgcagc   3462

 ccctatccct gctcaggagt gggctcagag tctagcaaat gctaaggccc ctcaggctgg   3522

 gctctgaacg aggacctgga ctcagagcca gacagggcag cctcagaccc ttctctgggg   3582

 ctcctggacc ttgggccata atttctgagc ctcggtttcc ccatctaagg aacagatgtg   3642

 gtcgttccgc cctctcagct ggatgagact gtcctggagg atccaccccg gaacagacag   3702

 aatggtgtct ctcaggatgg tgctctgaga gagggcagag tggatgcccc actgccctag   3762

 accctcggta gacgtggggt ctctggggcg gggtctgtgg ctgtgactga agtcggcttt   3822

 cccgttgatg tcttgatgct cctatctgtg cacttaccgt aggtagggac acgtgtccat   3882

 gcaccacaga cacacccacg acacctgatc tcgtatcact agcttgcggc caggtcatga   3942

 tgtggccccg gaagctggcc ctgcgtgcca tgagtgcgtc ggtcatggag tccggagccc   4002

 ctgagccggc ccctggtgac gcacagccct cacagctcaa acgcccaccc ccactcccac   4062

 catctgcagg tggtgaaaac aaaccccgtg tatctctcaa taaaggtggc cgaagggcct   4122

 cgatgtggaa aaaaaaaaaa aa                                            4144




      <210> 146
      <211> 546
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (23)..(493)

      <400> 146
 cgctcggctt cttcgcgccg ag atg cct aag aag gct ggt gcg acg acc aag      52
                          Met Pro Lys Lys Ala Gly Ala Thr Thr Lys
                            1               5                  10

 ggt aaa agc cag agc aag gaa cca gag aga cca ctt cct ccc tta ggt      100
 Gly Lys Ser Gln Ser Lys Glu Pro Glu Arg Pro Leu Pro Pro Leu Gly
                  15                  20                  25

 cct gtg gca gtt gat cct aaa gga tgc gtc acc ata gcc atc cat gca      148
 Pro Val Ala Val Asp Pro Lys Gly Cys Val Thr Ile Ala Ile His Ala
              30                  35                  40

 aaa cct ggc tcc aaa caa aat gct gta aca gat ttg aca gca gag gct      196
 Lys Pro Gly Ser Lys Gln Asn Ala Val Thr Asp Leu Thr Ala Glu Ala
          45                  50                  55

 gta aat gta gct att gca gca cct cca tca gag gga gag gct aat gct      244
 Val Asn Val Ala Ile Ala Ala Pro Pro Ser Glu Gly Glu Ala Asn Ala
      60                  65                  70

 gag ctc tgt cgg tat ctt tcc aag gtc cta gaa ctc agg aag agt gat      292
 Glu Leu Cys Arg Tyr Leu Ser Lys Val Leu Glu Leu Arg Lys Ser Asp
  75                  80                  85                  90

 gtg gtt ttg gat aag ggt ctc tca ctt tgt cac cca ggc tgg agc aca      340
 Val Val Leu Asp Lys Gly Leu Ser Leu Cys His Pro Gly Trp Ser Thr
                  95                 100                 105

 gcg gca caa cct cgg gtc act gca gcc ttg act tcc ctg gct caa aca      388
 Ala Ala Gln Pro Arg Val Thr Ala Ala Leu Thr Ser Leu Ala Gln Thr
             110                 115                 120

 atc ctc cca cct cag cct ccc aag ttg ctg gaa cta cag gtg cat gcc      436
 Ile Leu Pro Pro Gln Pro Pro Lys Leu Leu Glu Leu Gln Val His Ala
         125                 130                 135

 acc cac acc cgg cta att ttc gta ttt ttt gaa gag acg gga tct cgc      484
 Thr His Thr Arg Leu Ile Phe Val Phe Phe Glu Glu Thr Gly Ser Arg
     140                 145                 150

 cat gtt gcc taggctg gaagtcttgg gcttcggtga tcctcctgcc ttggcttccc      540
 His Val Ala 
 155

 aaagtg                                                               546




      <210> 147
      <211> 988
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (508)..(660)

      <400> 147
 agtactgttt taggtattgg ggatatacca aggaataaaa caagattcct ggagggagag     60

 gggaacggac agcaaacaat agacacaata cgatcgtgag gtatatagtt aatgttggtg    120

 atgagtgctc ctcaaaggaa acaactaaaa ccagacaagg gaagtcgggg tgtcagggag    180

 aatggtttgt agtattgatg acaatggtta aggaaggcct gagttctgca aagacctcaa    240

 ggatatgagg gactagagtg ccctctgctg tggaagagcc tgcgcaaaga tcctgaggtg    300

 ggaggggtca gggagccaac tcattttacg gtaagtggag gtgggatcca ggggaggatt    360

 ctgagcagag gagggacgtg gcccaatttg ggctttgaaa ggatcctgct tgtctgtgtg    420

 ccagcatcct ggtggtggtt gggggagtct gcatcaatcc tgggtgctgt tacctgaaaa    480

 aatagcaggt gttagacgaa agaacag    atg tct ggc cca ttg tct cca gtc     531
                                  Met Ser Gly Pro Leu Ser Pro Val
                                    1               5

 tgt tcc tgt cca cag ctt ccc ttt atg ctg agc ccc tgc cac atg cat      579
 Cys Ser Cys Pro Gln Leu Pro Phe Met Leu Ser Pro Cys His Met His
      10                  15                  20

 cat cat cct ggc cat gtg gca ttg tca cag acc gtc tct cct gct agc      627
 His His Pro Gly His Val Ala Leu Ser Gln Thr Val Ser Pro Ala Ser
  25                  30                  35                  40

 ctc cta act cag ggc ctg ggt ctt ccc cag cat taagtaaa tcagtctcag      678
 Leu Leu Thr Gln Gly Leu Gly Leu Pro Gln His 
                  45                  50

 gcagacagcc ctttataggt gtttgggcca ggtgcggtgg ctcacgcctg taatcccagc    738

 tctttgtggg gccgaggtct ttgagctcag gagttcaaga ccagcctggg cagcatgaca    798

 aaaccctgtc tctaccaaaa atacaaaaat tagccacgca tggtggcaca cacctgtggt    858

 cccagctact cgggaggctg aggtgggagg atcgctggag cctgggaagt tgaggctgca    918

 gtgagccgtg atcatgccac tgcattccag cctgtgtgat ggagagagac cctgtctcaa    978

 aaaaaaaaaa                                                           988




      <210> 148
      <211> 1131
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (117)..(683)

      <400> 148
 gtggtggaat tcccgggctc caggggttcc cacccccggc ctgcggtggg cagcagctca     60

 ggttctccaa atcattgcgt agttccgaat accctcggcc acacctggcc ttctcc        116                                                                 
 atg ctc gga ata act tcc tgc agc gac caa cag gct aaa gag ggg gaa      164
 Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu
   1               5                  10                  15

 ggt ctg gag gga tcc agc acc ggc tcc tcc tcc ggc aac cac ggt ggg      212
 Gly Leu Glu Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly
              20                  25                  30

 agc ggc gga gga aat gga cat aaa ccc ggg tgt gaa aag cca ggg aat      260
 Ser Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro Gly Asn
          35                  40                  45

 gaa gcc cgc ggg agc ggg gaa tct ggg att cag aac tct gag acg tct      308
 Glu Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Asn Ser Glu Thr Ser
      50                  55                  60

 cct ggg atg ttt aac ttt gac act ttc tgg aag aat ttt aaa tcc aag      356
 Pro Gly Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys
  65                  70                  75                  80

 ctg ggt ttc atc aac tgg gat gcc ata aac aag aac cag gtc ccg ccc      404
 Leu Gly Phe Ile Asn Trp Asp Ala Ile Asn Lys Asn Gln Val Pro Pro
                  85                  90                  95

 ccc agc acc cga gcc ctc ctc tac ttc agc cga ctc tgg gag gat ttc      452
 Pro Ser Thr Arg Ala Leu Leu Tyr Phe Ser Arg Leu Trp Glu Asp Phe
             100                 105                 110

 aaa cag aac act cct ttc ctc aac tgg aaa gca att att gag ggt gcg      500
 Lys Gln Asn Thr Pro Phe Leu Asn Trp Lys Ala Ile Ile Glu Gly Ala
         115                 120                 125

 gac gcg tca tca ctg cag aaa cgt gca ggc aga gcc gat cag aac tac      548
 Asp Ala Ser Ser Leu Gln Lys Arg Ala Gly Arg Ala Asp Gln Asn Tyr
     130                 135                 140

 aat tac aac cag cat gcg tat ccc act gcc tat ggt ggg aag tac tca      596
 Asn Tyr Asn Gln His Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser
 145                 150                 155                 160

 gtc aag acc cct gca aag ggg gga gtc tca cct tct tcc tcg gct tcc      644
 Val Lys Thr Pro Ala Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser
                 165                 170                 175

 cgg gtg caa cct ggc ctg ctg cag tgg gtg aag ttt tgg taggtgagtg       693
 Arg Val Gln Pro Gly Leu Leu Gln Trp Val Lys Phe Trp 
             180                 185

 tcagagtgag ccgacccagg ccacatcctg gcagtggagg cacagtcacc cggggcaggg    753

 ccaggatctt ggtatatcct cagatctcag tgggcagcga catgaagtca ggcaatttct    813

 tgcaaccacc accgaggccc cgaaaagcac tggtcgtcag ggagctcctc cccttggccc    873

 ccagcctgtg ccagccctgg cccggctgcc acacctctgt ttcctaggct ggggacccag    933

 cttgtctctc cttgtttctt cccactgcac tgtggtgctt cagtggccac cagcctcgtc    993

 acatacacca gcatctttct gtacctcctc cccttggtga cctgaagtca ctgtgacagt   1053

 tctccaggaa ggaggagctt cctacttttg agtttctctg tggaaataaa acatgaatct   1113

 tgtttcccta aaaaaaaa                                                 1131




      <210> 149
      <211> 1412
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1158)

      <400> 149
  atg act cgc cag tgc cag gcc tca aac caa cag ctc ggg ccc cag ccc      48
  Met Thr Arg Gln Cys Gln Ala Ser Asn Gln Gln Leu Gly Pro Gln Pro
    1               5                  10                  15

 ctg gcc aca acg cca cct gac ctg ttc ctg ggt ttt cag cag ctg ttt       96
 Leu Ala Thr Thr Pro Pro Asp Leu Phe Leu Gly Phe Gln Gln Leu Phe
              20                  25                  30

 ggg acc ttt gct agc tgg ggc cgg gag ccc cac tgc ggg ggc ccc gat      144
 Gly Thr Phe Ala Ser Trp Gly Arg Glu Pro His Cys Gly Gly Pro Asp
          35                  40                  45

 ttc ccc caa ccc atc cag acc gtt gaa gat gcc ctt agg aag cct tca      192
 Phe Pro Gln Pro Ile Gln Thr Val Glu Asp Ala Leu Arg Lys Pro Ser
      50                  55                  60

 gga ctt cag ctg att aat tac att cac act tat ctt cca ctt cct gca      240
 Gly Leu Gln Leu Ile Asn Tyr Ile His Thr Tyr Leu Pro Leu Pro Ala
  65                  70                  75                  80

 aag tac caa ata cac aga acc ttt cga cct gca cct cca gga ggt gtg      288
 Lys Tyr Gln Ile His Arg Thr Phe Arg Pro Ala Pro Pro Gly Gly Val
                  85                  90                  95

 gca ggc gtg ctt gtg gga cac ccg ttt gac acg gtc aag gta cgg ctt      336
 Ala Gly Val Leu Val Gly His Pro Phe Asp Thr Val Lys Val Arg Leu
             100                 105                 110

 cag gtc cag agc gtg gag aag cct cag tac cgc ggg acg ttg cac tgc      384
 Gln Val Gln Ser Val Glu Lys Pro Gln Tyr Arg Gly Thr Leu His Cys
         115                 120                 125

 ttc aag tcc atc atc aag caa gag agc gtg ctg ggc ctg tac aag ggc      432
 Phe Lys Ser Ile Ile Lys Gln Glu Ser Val Leu Gly Leu Tyr Lys Gly
     130                 135                 140

 ctg ggc tcg ccg ctc atg ggg ctc acc ttc atc aac gcg ctg gtg ttc      480
 Leu Gly Ser Pro Leu Met Gly Leu Thr Phe Ile Asn Ala Leu Val Phe
 145                 150                 155                 160

 ggg gtg cag ggc aac acc ctc cgg gcc ctg ggc cac gac tcg ccc ctc      528
 Gly Val Gln Gly Asn Thr Leu Arg Ala Leu Gly His Asp Ser Pro Leu
                 165                 170                 175

 aac cag ttc ctg gca ggt gcg gcg gcg ggc gcc atc cag tgc gtc atc      576
 Asn Gln Phe Leu Ala Gly Ala Ala Ala Gly Ala Ile Gln Cys Val Ile
             180                 185                 190

 tgc tgc ccc atg gag ctg gcc aag acg cgg ctg cag ctg cag gac gcg      624
 Cys Cys Pro Met Glu Leu Ala Lys Thr Arg Leu Gln Leu Gln Asp Ala
         195                 200                 205

 ggc cca gcg cgc acc tac aag ggc tcg ctg gac tgc ctc gcg cag atc      672
 Gly Pro Ala Arg Thr Tyr Lys Gly Ser Leu Asp Cys Leu Ala Gln Ile
     210                 215                 220

 tac ggg cac gag ggt ctg cgt ggc gtc aac cgg ggc atg gtg tcc acg      720
 Tyr Gly His Glu Gly Leu Arg Gly Val Asn Arg Gly Met Val Ser Thr
 225                 230                 235                 240

 ttg ctg cgt gag acg ccc agc ttc ggc gtc tac ttc ctc acc tat gac      768
 Leu Leu Arg Glu Thr Pro Ser Phe Gly Val Tyr Phe Leu Thr Tyr Asp
                 245                 250                 255

 gct ctc acg cgg gcg ctg ggc tgc gag ccg ggc gac cgc ctg ctg gtg      816
 Ala Leu Thr Arg Ala Leu Gly Cys Glu Pro Gly Asp Arg Leu Leu Val
             260                 265                 270

 ccc aag ctg ctg ttg gcg ggc ggt acg tca ggc atc gtg tcc tgg ctc      864
 Pro Lys Leu Leu Leu Ala Gly Gly Thr Ser Gly Ile Val Ser Trp Leu
         275                 280                 285

 tct acc tat cct gtg gac gtg gtc aag tcg cgg ctg cag gcg gac gga      912
 Ser Thr Tyr Pro Val Asp Val Val Lys Ser Arg Leu Gln Ala Asp Gly
     290                 295                 300

 ctg cgg ggc gcc ccg cgc tac cgc ggc atc ctg gac tgc gtg cac cag      960
 Leu Arg Gly Ala Pro Arg Tyr Arg Gly Ile Leu Asp Cys Val His Gln
 305                 310                 315                 320

 agc tac cgc gcc gag ggc tgg cgc gtc ttc aca cgg ggg ctg gcg tcc     1008
 Ser Tyr Arg Ala Glu Gly Trp Arg Val Phe Thr Arg Gly Leu Ala Ser
                 325                 330                 335

 acg ctg ctg cgc gcc ttc ccc gtc aac gct gcc acc ttc gcc acc gtc     1056
 Thr Leu Leu Arg Ala Phe Pro Val Asn Ala Ala Thr Phe Ala Thr Val
             340                 345                 350

 acg gtg gtg ctc acc tac gcg cgc ggc gag gag gcc ggg ccc gag ggc     1104
 Thr Val Val Leu Thr Tyr Ala Arg Gly Glu Glu Ala Gly Pro Glu Gly
         355                 360                 365

 gag gct gtg ccc gcc gcc cct gcg ggg cct gcc ctg gcg cag ccc tcc     1152
 Glu Ala Val Pro Ala Ala Pro Ala Gly Pro Ala Leu Ala Gln Pro Ser
     370                 375                 380

 agc ctg tgacgctcac cccgccctcc ttccccaggg ctccttctca gaaacctggg      1208
 Ser Leu 
 385

 acataaattg gcccctgagt cgattgccct gcttcctgct gggatgctgc gagctgtgga   1268

 gtctatcaga cgtgggctga attttgctga tcagctgggt agttttggcc gagaactgca   1328

 cttgcctcag tgttctcatc tatgaaataa ggaccctcat gcccacactg tagagtcacg   1388

 aagctcagag attattccca gcag                                          1412




      <210> 150
      <211> 1937
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (201)..(1934)

      <400> 150
 aggcgagatc ttccaccctc ctgctccagg gcctctaggt ggcctccaga gtgggctcca     60

 cagcttgaag gcggcgtttt tccgcgggtg gtcgcagcgt ccgcagagtc ggagaaagct    120

 gcgtcagaga ctgcaacagt cagcacacat tcctgtctga tcaggctccc tccctcaagt    180

 cctctgcgat agctctggcg    atg ctt cag gac tgg tgc agg agg atg ggt     230
                          Met Leu Gln Asp Trp Cys Arg Arg Met Gly
                            1               5                  10

 gtg aac gca gag cgc tct ctg ctc atc ctg gat atc cct gac gac tgc      278
 Val Asn Ala Glu Arg Ser Leu Leu Ile Leu Asp Ile Pro Asp Asp Cys
                  15                  20                  25

 gag gaa cat gag ttc cag gag gcc gtg cgg gct gcc ctg tcg ccc ctg      326
 Glu Glu His Glu Phe Gln Glu Ala Val Arg Ala Ala Leu Ser Pro Leu
              30                  35                  40

 ggc agg tac cga gtg ctc atc aag gtc ttc aga aag gag ctc ggg gcc      374
 Gly Arg Tyr Arg Val Leu Ile Lys Val Phe Arg Lys Glu Leu Gly Ala
          45                  50                  55

 agg gca gcc ttg gtg gaa ttc gct gag ggt tta aac caa agc ttg att      422
 Arg Ala Ala Leu Val Glu Phe Ala Glu Gly Leu Asn Gln Ser Leu Ile
      60                  65                  70

 ccc cgc caa ata gca ggc aaa ggg gga ccc tgg aaa gtg atc tcc ctg      470
 Pro Arg Gln Ile Ala Gly Lys Gly Gly Pro Trp Lys Val Ile Ser Leu
  75                  80                  85                  90

 ccc cag gcc ctt gat gct gag ttt cag gat ata ccc agt ttc cct gca      518
 Pro Gln Ala Leu Asp Ala Glu Phe Gln Asp Ile Pro Ser Phe Pro Ala
                  95                 100                 105

 cag ccc cag ggg caa gca gtg gcc aga ggt gca ggt gaa gca gga gct      566
 Gln Pro Gln Gly Gln Ala Val Ala Arg Gly Ala Gly Glu Ala Gly Ala
             110                 115                 120

 gca ggt gag gca gga tct gta ggt gag gca gga ggt gtg aat gag gaa      614
 Ala Gly Glu Ala Gly Ser Val Gly Glu Ala Gly Gly Val Asn Glu Glu
         125                 130                 135

 aga tct gca ggt gaa gat gag gca gga ggt ata ggt gag gca gga ggt      662
 Arg Ser Ala Gly Glu Asp Glu Ala Gly Gly Ile Gly Glu Ala Gly Gly
     140                 145                 150

 gta ggt gag gca gga gca gca ggt gag gca gga gca gca ggt gag gca      710
 Val Gly Glu Ala Gly Ala Ala Gly Glu Ala Gly Ala Ala Gly Glu Ala
 155                 160                 165                 170

 gga gca gca ggt gag gca gga ggt gca ggt gag gca gga ggt gca ggt      758
 Gly Ala Ala Gly Glu Ala Gly Gly Ala Gly Glu Ala Gly Gly Ala Gly
                 175                 180                 185

 gag gca gga ggt gca ggt gag gaa gga ggt aca ggt gag gaa gga ggt      806
 Glu Ala Gly Gly Ala Gly Glu Glu Gly Gly Thr Gly Glu Glu Gly Gly
             190                 195                 200

 gca ggt gag gca gga ggc gca ggt gag gaa gga ggt gaa gat gag gca      854
 Ala Gly Glu Ala Gly Gly Ala Gly Glu Glu Gly Gly Glu Asp Glu Ala
         205                 210                 215

 gga gct gca ggt gag gca gta ggt gca ggt gtg gtg gag gcc tgg acc      902
 Gly Ala Ala Gly Glu Ala Val Gly Ala Gly Val Val Glu Ala Trp Thr
     220                 225                 230

 cag tca tgg cgc cag acc ctg cgg cct ctg gtg aaa act atg gcc tac      950
 Gln Ser Trp Arg Gln Thr Leu Arg Pro Leu Val Lys Thr Met Ala Tyr
 235                 240                 245                 250

 cgg gaa ctg aga ccc ttt tcc ggg agg gag cag cca ggc tgc gtg gaa      998
 Arg Glu Leu Arg Pro Phe Ser Gly Arg Glu Gln Pro Gly Cys Val Glu
                 255                 260                 265

 gag tcc ttt gag agc tgg ttg gag gac gcc aag gat atg ctg cag ctg     1046
 Glu Ser Phe Glu Ser Trp Leu Glu Asp Ala Lys Asp Met Leu Gln Leu
             270                 275                 280

 tgg tgc cac gcg tcg gaa agg gag aga agg agg cgg ctg ctg gac agc     1094
 Trp Cys His Ala Ser Glu Arg Glu Arg Arg Arg Arg Leu Leu Asp Ser
         285                 290                 295

 ttg gat ggc ctg gcc ctg gat atc gtg agc ggc ctc ctg gag gaa gat     1142
 Leu Asp Gly Leu Ala Leu Asp Ile Val Ser Gly Leu Leu Glu Glu Asp
     300                 305                 310

 cca gac ttc tct gcg cag gac tgc ctg acg gcg ctg ggg cag gtg ttt     1190
 Pro Asp Phe Ser Ala Gln Asp Cys Leu Thr Ala Leu Gly Gln Val Phe
 315                 320                 325                 330

 agg agc cgg gat aca tgg atg acc tcg cgg atg aag ttc ctg acc tgc     1238
 Arg Ser Arg Asp Thr Trp Met Thr Ser Arg Met Lys Phe Leu Thr Cys
                 335                 340                 345

 acg cag ggg ccc cag gag ggg ctg ttt gcc ttc gtg gtg cgc ctg gaa     1286
 Thr Gln Gly Pro Gln Glu Gly Leu Phe Ala Phe Val Val Arg Leu Glu
             350                 355                 360

 ggc ctg ctg cag aag gcc gtg gag aag ggg gcg gtc cac cca gcc atg     1334
 Gly Leu Leu Gln Lys Ala Val Glu Lys Gly Ala Val His Pro Ala Met
         365                 370                 375

 gcc aac cac ctg cga ctg cgg cag gtg ctg tct cgg gcc cgc ccc agc     1382
 Ala Asn His Leu Arg Leu Arg Gln Val Leu Ser Arg Ala Arg Pro Ser
     380                 385                 390

 gag gca ctc cag gat acc ctg agg agg atg cag ctg gag agg agg cca     1430
 Glu Ala Leu Gln Asp Thr Leu Arg Arg Met Gln Leu Glu Arg Arg Pro
 395                 400                 405                 410

 cct gac ttc ctg agg ctg ctg cgg ctc atc cgg gac atg gag gcg tgg     1478
 Pro Asp Phe Leu Arg Leu Leu Arg Leu Ile Arg Asp Met Glu Ala Trp
                 415                 420                 425

 gca gcc tcc cta gca agg agc cag cag ggt gtg gcc tgg gca gcg gcc     1526
 Ala Ala Ser Leu Ala Arg Ser Gln Gln Gly Val Ala Trp Ala Ala Ala
             430                 435                 440

 cca gtg gag agt gaa gac cca gct gct gcc cag gcc tcc ccg gcc cag     1574
 Pro Val Glu Ser Glu Asp Pro Ala Ala Ala Gln Ala Ser Pro Ala Gln
         445                 450                 455

 ggg gac gcc agc gag gct gat ccc gga gca gaa gat gct gat gag gct     1622
 Gly Asp Ala Ser Glu Ala Asp Pro Gly Ala Glu Asp Ala Asp Glu Ala
     460                 465                 470

 gct tcc acc acc aaa gag gcc gcc agg gtt gcc cct gcc act ggg gaa     1670
 Ala Ser Thr Thr Lys Glu Ala Ala Arg Val Ala Pro Ala Thr Gly Glu
 475                 480                 485                 490

 gat gaa aat gcc cct gca ggc ctt gaa ggc cta ggt cag gga agg tcc     1718
 Asp Glu Asn Ala Pro Ala Gly Leu Glu Gly Leu Gly Gln Gly Arg Ser
                 495                 500                 505

 ccc gac gcc cct ggg ggc ctc cca gcc agg atg ggc agt gca gtc gac     1766
 Pro Asp Ala Pro Gly Gly Leu Pro Ala Arg Met Gly Ser Ala Val Asp
             510                 515                 520

 atg gcc cca gga ggt ccc agc tgg gag cca gag ggc ctt gtc cag gtt     1814
 Met Ala Pro Gly Gly Pro Ser Trp Glu Pro Glu Gly Leu Val Gln Val
         525                 530                 535

 gga ggc cag gag gct gag gag cct ccc cag gag ggg ctc aag ccc atc     1862
 Gly Gly Gln Glu Ala Glu Glu Pro Pro Gln Glu Gly Leu Lys Pro Ile
     540                 545                 550

 tta gag gag tca gaa aac gag gat gag gat ggg gct ggg gag gcg ggc     1910
 Leu Glu Glu Ser Glu Asn Glu Asp Glu Asp Gly Ala Gly Glu Ala Gly
 555                 560                 565                 570

 aag ccc aag tcc ccc ccg ggc aaa tag                                 1937
 Lys Pro Lys Ser Pro Pro Gly Lys 
                 575





      <210> 151
      <211> 2545
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (365)..(1642)

      <400> 151
 aggacgagaa cattctgggt tggacgattc tcggaatact gcccttcttg cttggaaaat     60

 gatcagagat ggttgtgtaa tgaaaattac aaggtcgttg aacaaggtta gtagtgtctt    120

 gcctttttat tctgtcatct caaacttcat aaacagtcat acgttctttg aaacgtagat    180

 ttaatgtgtg cagtcattta taaatcaatg acatttctct tttttgtcat aaaactgtat    240

 actgaagaaa ttaacgaatg cacagtttct aaagctgttg catttgtctg tggaatcata    300

 ggttcccact aagaagaatt tcagcattct ggccagaaat ttgaatacaa ttcaagttga    360

 agaa atg tct gcc tgt aac att agc atc cag ggt ccc agc ata tat aat     409
      Met Ser Ala Cys Asn Ile Ser Ile Gln Gly Pro Ser Ile Tyr Asn
        1               5                  10                  15

 aag gag cct aaa aat ata ata aat cct cat gaa aaa gtt caa atg aag      457
 Lys Glu Pro Lys Asn Ile Ile Asn Pro His Glu Lys Val Gln Met Lys
                  20                  25                  30

 tca att tgt gca aat tct cct ata aag gca caa cag gat caa tta caa      505
 Ser Ile Cys Ala Asn Ser Pro Ile Lys Ala Gln Gln Asp Gln Leu Gln
              35                  40                  45

 gta aaa aac aat ata aaa gca agt ctt cac aat gtc aaa agt tcc tta      553
 Val Lys Asn Asn Ile Lys Ala Ser Leu His Asn Val Lys Ser Ser Leu
          50                  55                  60

 cct ctt ttt aat act aag tcc tct act tct gtg ggg cag ttg cag tct      601
 Pro Leu Phe Asn Thr Lys Ser Ser Thr Ser Val Gly Gln Leu Gln Ser
      65                  70                  75

 cct acc ttg aat tca cct atc tat atg caa aag caa gga aaa aat gaa      649
 Pro Thr Leu Asn Ser Pro Ile Tyr Met Gln Lys Gln Gly Lys Asn Glu
  80                  85                  90                  95

 cat ctt gca ttt aat acc aaa tct aag gct tca aca gtt ggt tca gaa      697
 His Leu Ala Phe Asn Thr Lys Ser Lys Ala Ser Thr Val Gly Ser Glu
                 100                 105                 110

 ttg gta ctt gtt tct acc acc gtt cca act gtt cat cat gtt tct gat      745
 Leu Val Leu Val Ser Thr Thr Val Pro Thr Val His His Val Ser Asp
             115                 120                 125

 ttg gaa atg agc tct act ctg gac tgt tta cct gtg ttg gct gat tgg      793
 Leu Glu Met Ser Ser Thr Leu Asp Cys Leu Pro Val Leu Ala Asp Trp
         130                 135                 140

 gag gat gtg gtt tta ctg cca gca tct cag cct gag gaa aac gta gac      841
 Glu Asp Val Val Leu Leu Pro Ala Ser Gln Pro Glu Glu Asn Val Asp
     145                 150                 155

 tgt aca gtt ccc att agt gac tca gac tta gag att tca ttt aat tct      889
 Cys Thr Val Pro Ile Ser Asp Ser Asp Leu Glu Ile Ser Phe Asn Ser
 160                 165                 170                 175

 gga gaa aga tta atg gtt ttg aaa gaa ttg gaa atg tca agt cat gaa      937
 Gly Glu Arg Leu Met Val Leu Lys Glu Leu Glu Met Ser Ser His Glu
                 180                 185                 190

 aac ttt gga gac ata gag gaa act cct caa aaa tct gag act tct aag      985
 Asn Phe Gly Asp Ile Glu Glu Thr Pro Gln Lys Ser Glu Thr Ser Lys
             195                 200                 205

 tct att gtg tac aag agt cct cac act act att tat aat gta aaa gaa     1033
 Ser Ile Val Tyr Lys Ser Pro His Thr Thr Ile Tyr Asn Val Lys Glu
         210                 215                 220

 gcc aaa gat cca ggt tca gat att tct gcc ttt aag tta cct gaa cac     1081
 Ala Lys Asp Pro Gly Ser Asp Ile Ser Ala Phe Lys Leu Pro Glu His
     225                 230                 235

 aaa tca agt acc ttc aac aga gtt aat gcc aat atg tct cat cct tta     1129
 Lys Ser Ser Thr Phe Asn Arg Val Asn Ala Asn Met Ser His Pro Leu
 240                 245                 250                 255

 gtt ttg ggg aaa cat cct ctt ctt tca ggt ggt acc aaa agg aat cca     1177
 Val Leu Gly Lys His Pro Leu Leu Ser Gly Gly Thr Lys Arg Asn Pro
                 260                 265                 270

 tgc agt ccc caa gct ttc cca cca gca aaa aaa caa ccc ttc act att     1225
 Cys Ser Pro Gln Ala Phe Pro Pro Ala Lys Lys Gln Pro Phe Thr Ile
             275                 280                 285

 cat gaa gaa aag cct aca tca tct gat tgc tcc cca gta aga agt tct     1273
 His Glu Glu Lys Pro Thr Ser Ser Asp Cys Ser Pro Val Arg Ser Ser
         290                 295                 300

 tcc tgg agg cgt ctc cca tct ata tta act tct aca gtt aac cta caa     1321
 Ser Trp Arg Arg Leu Pro Ser Ile Leu Thr Ser Thr Val Asn Leu Gln
     305                 310                 315

 gag cca tgg aag agt ggg aaa atg aca cct cca tta tgc aag tgt ggt     1369
 Glu Pro Trp Lys Ser Gly Lys Met Thr Pro Pro Leu Cys Lys Cys Gly
 320                 325                 330                 335

 cgg aga tct aag aga ctt gtt gtt tct aat aat gga cct aac cat gga     1417
 Arg Arg Ser Lys Arg Leu Val Val Ser Asn Asn Gly Pro Asn His Gly
                 340                 345                 350

 aaa gtc ttc tat tgt tgc cct atc ggg aaa tac caa gaa aac aga aaa     1465
 Lys Val Phe Tyr Cys Cys Pro Ile Gly Lys Tyr Gln Glu Asn Arg Lys
             355                 360                 365

 tgt tgt ggt tat ttc aaa tgg gaa caa aca ctt caa aag gaa aga gcc     1513
 Cys Cys Gly Tyr Phe Lys Trp Glu Gln Thr Leu Gln Lys Glu Arg Ala
         370                 375                 380

 aac agc atg gtt cca tct cat tcc aca ggg gga ctc act ttt agt tct     1561
 Asn Ser Met Val Pro Ser His Ser Thr Gly Gly Leu Thr Phe Ser Ser
     385                 390                 395

 cca gaa aca agc cat att tgt gac aga aat tta agt att tcc acc aaa     1609
 Pro Glu Thr Ser His Ile Cys Asp Arg Asn Leu Ser Ile Ser Thr Lys
 400                 405                 410                 415

 aat tct ttg aga ctc agg cct tca atg agg aat tgataacc tttcatgtat     1660
 Asn Ser Leu Arg Leu Arg Pro Ser Met Arg Asn 
                 420                 425

 gaatcctaat tgttccttga atttccaaac atgagtattc tgataacatc ttacactatt   1720

 ttatttttat tttatatatt aatgtttact gcatttacca tactttcttc aggaaccaca   1780

 agtgtaatct tttgtaaaca gtatttatta gattacatat aataagcaac aatagtatat   1840

 gatccttctt ttatagttag accttgaaac aagtctaaac tatttttaaa ttatttgcaa   1900

 aaaatgtgac taataaaaat ccctagtcta ttttcaggta gattcttgta ctttgagatt   1960

 atcataatct tctaactgga attttatatt tttctaaaaa cttttataag ttctttagtt   2020

 ttatttcagg cttgaacatt ggttctgatt tgtatatcaa catatcagaa gaattagtca   2080

 actaaagttt gaaaacctat gtagcagaga tctggttcag aaactgcttc tatactatac   2140

 atttaaaaat taatcagcaa ttgatggtat tatttttata ttaagaaatg ataggaacat   2200

 tgacactaat gtggaggaat ttgccaaata ttttatttca aaatttagcc tctgatatca   2260

 taaccacaag atattttaaa tcaacagttt ctaagcatac taccacagtt tttatgacct   2320

 ctccatcatc ttgtgtttct agagattgac agatacctat gttggtttat agatatggta   2380

 attaatgaaa caacttttaa ttgtcttcca ttctttcttt cttaggtcat ttcttttgtc   2440

 ttcccactga tagtctttgc agctcttgaa taattctacc tttctgggga atttggaagg   2500

 ggctgagttt ttacatgctc ctgaatctcc tttatagtgg tctgg                   2545




      <210> 152
      <211> 1245
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (295)..(1242)

      <400> 152
 gcgggcggca gaggcgatca gaagtttcca agggtcactt gtgtctcgtc cgtgggaaga     60

 ccgggggagc ccagaaggcc ttggtgtgga attctgagag ctgattcctg ccttgtcttc    120

 tccactgttc ctggaggaat ccgagaagag cagagcggag ggagccccag acacggtccg    180

 cgggagagct gtggggcttg gtgagtgttt cgtggcctct cgggttggtc agcaccccca    240

 gccagctggc ccaggacccc tctacagaag tccaggagag caggcgtcac caag  atg     297
                                                              Met
                                                                1

 tcc aac ccc ttc ctg aag caa gtc ttc aac aag gac aag aca ttc cgc      345
 Ser Asn Pro Phe Leu Lys Gln Val Phe Asn Lys Asp Lys Thr Phe Arg
               5                  10                  15

 ccc aag cgc aag ttt gag cca ggc acc cag cgc ttc gag ctg cac aag      393
 Pro Lys Arg Lys Phe Glu Pro Gly Thr Gln Arg Phe Glu Leu His Lys
          20                  25                  30

 aag gcg cag gcg tcg ctg aac gcc ggg ctg gac ctg cgg ctg gcc gtg      441
 Lys Ala Gln Ala Ser Leu Asn Ala Gly Leu Asp Leu Arg Leu Ala Val
      35                  40                  45

 cag ttg ccc ccg ggc gag gac ctg aac gac tgg gtg gct gtt cac gtg      489
 Gln Leu Pro Pro Gly Glu Asp Leu Asn Asp Trp Val Ala Val His Val
  50                  55                  60                  65

 gtg gac ttc ttt aac cgc gtc aac ctc atc tac ggc acc atc agc gac      537
 Val Asp Phe Phe Asn Arg Val Asn Leu Ile Tyr Gly Thr Ile Ser Asp
                  70                  75                  80

 ggc tgc acg gag cag tcc tgc ccc gtc atg tcg ggg ggc ccc aag tat      585
 Gly Cys Thr Glu Gln Ser Cys Pro Val Met Ser Gly Gly Pro Lys Tyr
              85                  90                  95

 gag tac cgc tgg cag gat gag cat aag ttc cgg aag ccc acg gca ctc      633
 Glu Tyr Arg Trp Gln Asp Glu His Lys Phe Arg Lys Pro Thr Ala Leu
         100                 105                 110

 tcc gcg ccc agg tac atg gac ctg ctg atg gac tgg atc gag gcg cag      681
 Ser Ala Pro Arg Tyr Met Asp Leu Leu Met Asp Trp Ile Glu Ala Gln
     115                 120                 125

 atc aac aac gag gac ctc ttc ccc acc aac gtt ggc act ccg ttt ccc      729
 Ile Asn Asn Glu Asp Leu Phe Pro Thr Asn Val Gly Thr Pro Phe Pro
 130                 135                 140                 145

 aag aac ttc ctg cag acg gtg cgg aag atc ctg tcg cgg ctg ttc cgc      777
 Lys Asn Phe Leu Gln Thr Val Arg Lys Ile Leu Ser Arg Leu Phe Arg
                 150                 155                 160

 gtg ttc gtg cac gtc tac atc cac cac ttt gac cgc atc gcg cag atg      825
 Val Phe Val His Val Tyr Ile His His Phe Asp Arg Ile Ala Gln Met
             165                 170                 175

 ggc tcc gag gcc cac gtg aac acc tgc tac aag cac ttc tac tat ttc      873
 Gly Ser Glu Ala His Val Asn Thr Cys Tyr Lys His Phe Tyr Tyr Phe
         180                 185                 190

 gtc aag gag ttc ggc ctc atc gac acc aag gag ctg gag cca ctg gtg      921
 Val Lys Glu Phe Gly Leu Ile Asp Thr Lys Glu Leu Glu Pro Leu Val
     195                 200                 205

 cgc ggg ctt ggg gct gag ggc gtg cgg tta cgc tgg cgg ccc cgg ctg      969
 Arg Gly Leu Gly Ala Glu Gly Val Arg Leu Arg Trp Arg Pro Arg Leu
 210                 215                 220                 225

 gag ttg ggc ccc ggg gac cct gct gat ggg aca agt ggt gag gta gct     1017
 Glu Leu Gly Pro Gly Asp Pro Ala Asp Gly Thr Ser Gly Glu Val Ala
                 230                 235                 240

 ggg agg gat cct gcg ttc tcc cac gga aca aat gcc ggc gac aga tct     1065
 Gly Arg Asp Pro Ala Phe Ser His Gly Thr Asn Ala Gly Asp Arg Ser
             245                 250                 255

 gaa aat gct gac tct ctg gcc tca tgg ggt agc ctg ctg ccc ctg gtc     1113
 Glu Asn Ala Asp Ser Leu Ala Ser Trp Gly Ser Leu Leu Pro Leu Val
         260                 265                 270

 tca gaa aga aat gac cgc ccg gat gtg cca ctg aga gcc ccg cgg gtc     1161
 Ser Glu Arg Asn Asp Arg Pro Asp Val Pro Leu Arg Ala Pro Arg Val
     275                 280                 285

 tcc cgg tgc ccg aac cgc cgc tgg ggc ctc gga gac ttg gag gag gac     1209
 Ser Arg Cys Pro Asn Arg Arg Trp Gly Leu Gly Asp Leu Glu Glu Asp
 290                 295                 300                 305

 gct ctg gaa cca tca tcc cgc ttc tct ccg gcc tga                     1245
 Ala Leu Glu Pro Ser Ser Arg Phe Ser Pro Ala 
                 310                 315





      <210> 153
      <211> 1574
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (101)..(901)

      <400> 153
 atgctgcccc tgctcgccgc gctcctggcc gccgcctgcc cgctgccgcc cgtccgcggc     60

 ggggccgcgg acgcgcccgg cctcctcggg gtgccctcca  atg ctt cag tca acg     115
                                              Met Leu Gln Ser Thr
                                                1               5

 cgt cct ccg cgg acg agc cca tcg ccc cgc ggc tgc tgg cct cgg cgg      163
 Arg Pro Pro Arg Thr Ser Pro Ser Pro Arg Gly Cys Trp Pro Arg Arg
                  10                  15                  20

 ccc ccg ggc ccc ccg agc gcc cgg gcc cgg agg agg cgg cgg cgg cgg      211
 Pro Pro Gly Pro Pro Ser Ala Arg Ala Arg Arg Arg Arg Arg Arg Arg
              25                  30                  35

 cgg cgc ctg tgc aac atc agc gtg cag cgg cag atg ctg agc tcg ctg      259
 Arg Arg Leu Cys Asn Ile Ser Val Gln Arg Gln Met Leu Ser Ser Leu
          40                  45                  50

 ctc gtg cgc tgg ggc cgc ccg cgg ggc ttc cag tgc gac cta ctg ctc      307
 Leu Val Arg Trp Gly Arg Pro Arg Gly Phe Gln Cys Asp Leu Leu Leu
      55                  60                  65

 ttc tcc acc aac gcg cac ggc cgc gct ttc ttc gcc gcc gcc ttc cac      355
 Phe Ser Thr Asn Ala His Gly Arg Ala Phe Phe Ala Ala Ala Phe His
  70                  75                  80                  85

 cgc gtc ggg ccg ccg ctg ctc atc gag cac ctg ggg ctg gcg gcg ggc      403
 Arg Val Gly Pro Pro Leu Leu Ile Glu His Leu Gly Leu Ala Ala Gly
                  90                  95                 100

 ggc gcg cag cag gac ctg cgc ctc tgc gtg ggc tgc ggc tgg gtg cgc      451
 Gly Ala Gln Gln Asp Leu Arg Leu Cys Val Gly Cys Gly Trp Val Arg
             105                 110                 115

 ggt cgc cgc acc ggc cgc ctc cgg ccc gcc gcc gcc ccc agc gcc gcc      499
 Gly Arg Arg Thr Gly Arg Leu Arg Pro Ala Ala Ala Pro Ser Ala Ala
         120                 125                 130

 gcc gcc acc gcc ggg gcg ccc acc gcg ctg cca gcc tac ccc gcg gcc      547
 Ala Ala Thr Ala Gly Ala Pro Thr Ala Leu Pro Ala Tyr Pro Ala Ala
     135                 140                 145

 gag ccg ccc ggg ccg ctg tgg ctg cag ggc gag ccg ctg cat ttc tgc      595
 Glu Pro Pro Gly Pro Leu Trp Leu Gln Gly Glu Pro Leu His Phe Cys
 150                 155                 160                 165

 tgc cta gac ttc agc ctg gag gag ctg cag ggc gag ccg ggc tgg cgg      643
 Cys Leu Asp Phe Ser Leu Glu Glu Leu Gln Gly Glu Pro Gly Trp Arg
                 170                 175                 180

 ctg aac cgt aag ccc att gag tcc acg ctg gtg gcc tgc ttc atg acc      691
 Leu Asn Arg Lys Pro Ile Glu Ser Thr Leu Val Ala Cys Phe Met Thr
             185                 190                 195

 ctg gtc atc gtg gtg tgg agc gtg gcc gcc ctc atc tgg ccg gtg ccc      739
 Leu Val Ile Val Val Trp Ser Val Ala Ala Leu Ile Trp Pro Val Pro
         200                 205                 210

 atc atc gcc ggc ttc ctg ccc aac ggc atg gaa cag cgc cgg acc acc      787
 Ile Ile Ala Gly Phe Leu Pro Asn Gly Met Glu Gln Arg Arg Thr Thr
     215                 220                 225

 gcc agc acc acc gca gcc acc ccc gcc gca gtg ccc gca ggg acc acc      835
 Ala Ser Thr Thr Ala Ala Thr Pro Ala Ala Val Pro Ala Gly Thr Thr
 230                 235                 240                 245

 gca gcc gcc gcc gcc gcc gcc gct gcc gcc gcc gcc gcg gcc gtc act      883
 Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Thr
                 250                 255                 260

 tcg ggg gtg gcg acc aag tgaccc gctccgctcc tccctgtgtc cgtcctgtgt      937
 Ser Gly Val Ala Thr Lys 
             265

 ccgcgcgcgc gggtgccttt cccgccgggg actcggccgg tgtgcttcgt gctgtagtta    997

 tcgttagttc ctcttcccga gatggggccg ccgagagacc ccagcgcctt tgaaaagcaa   1057

 ggtttgtgct gcgcttccag ttccgaaaag cagatgttta agcccttgga ctgagggtgg   1117

 gatcgcagct ccgaagacgg agaggaggga aatggggccc tttcccctct attgcatccc   1177

 cctgcccgac tccttccccg cacccacgtg ccctagattc atggcagaaa atgaccaaat   1237

 cctgtgtatt tgttttatat atttaataac tgttttaaat gaaagtttta gtaaaaaaaa   1297

 tacaaaacaa aaagattaaa ttgctattgc tgtagtaaga gaagctcttt gtatctgaac   1357

 atagttgtat ttgaaatttg tggtttttta atttatttaa aattgggggg agggcatggg   1417

 aaggatttaa caccgatata ttgttaccgc tgaaaatgaa ctttatgaac cttttccaag   1477

 ttgatctatc cagtgacgtg gcctggtggg cgtttcttct tgtacttatg tggttttttg   1537

 gcttttaata cagacatttt cctccaaaaa aaaaaaa                            1574




      <210> 154
      <211> 1974
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (315)..(806)

      <400> 154
 atgagtaagc cagaatggtt gatagtgggg gaggatgatg acgacgctgc ctttgcccct     60

 gtcttgtgtg aaacaactgc ctgtgggttt cctgcagcgc agtggggagt gagaggagaa    120

 acgtcctgcc gtgccacacc cacgccctcc cctgcgaacg cgcacgtgaa cgggagcgcg    180

 gacgcgcccg agaatgcgct tcacctcgca gaagcggcac ctcggctgct gcccggcagc    240

 ggcagcagct gcgtcggcgg cccacacagc agcgagaggc gagaggaggc tgcctcgagg    300

 aggctgcctc gagg  atg aag tgc aaa ccc aac cag acg cgg acc tac gac     350
                  Met Lys Cys Lys Pro Asn Gln Thr Arg Thr Tyr Asp
                    1               5                  10

 ccc gag ggg ttc aag aag cgg gcg gcg tgc ctg tgc ttc cgg agc gaa      398
 Pro Glu Gly Phe Lys Lys Arg Ala Ala Cys Leu Cys Phe Arg Ser Glu
          15                  20                  25

 cgc gag gac gag gtc ctg tta gtg agt agc agc cgg tac ccg gac cgc      446
 Arg Glu Asp Glu Val Leu Leu Val Ser Ser Ser Arg Tyr Pro Asp Arg
      30                  35                  40

 tgg atc gtg ccg ggc ggg ggc atg gag ccc gag gag gag ccg ggc ggt      494
 Trp Ile Val Pro Gly Gly Gly Met Glu Pro Glu Glu Glu Pro Gly Gly
  45                  50                  55                  60

 gcg gcg gtc cga gag gtg tac gaa gaa gcg gga gtc aag ggg aag tta      542
 Ala Ala Val Arg Glu Val Tyr Glu Glu Ala Gly Val Lys Gly Lys Leu
                  65                  70                  75

 ggc cgg ctc ctg ggc gtc ttc gaa cag aac cag gac ccc aag cac aga      590
 Gly Arg Leu Leu Gly Val Phe Glu Gln Asn Gln Asp Pro Lys His Arg
              80                  85                  90

 acg tac gtg tat gta ctg act gtc acg gag ctg ctg gag gat tgg gaa      638
 Thr Tyr Val Tyr Val Leu Thr Val Thr Glu Leu Leu Glu Asp Trp Glu
          95                 100                 105

 gat tcg gtt agc att ggg agg aag cga gag tgg ttc aaa gtc gaa gat      686
 Asp Ser Val Ser Ile Gly Arg Lys Arg Glu Trp Phe Lys Val Glu Asp
     110                 115                 120

 gcc atc aag gtt ctc cag tgc cac aag ccc gtg cac gcc gaa tat ctg      734
 Ala Ile Lys Val Leu Gln Cys His Lys Pro Val His Ala Glu Tyr Leu
 125                 130                 135                 140

 gag aaa cta aag ctg ggc ggt tcc cca acc aat gga aac tcc atg gcc      782
 Glu Lys Leu Lys Leu Gly Gly Ser Pro Thr Asn Gly Asn Ser Met Ala
                 145                 150                 155

 cca tcc tcg cca gat agc gat ccc taatgaacag caaagatgtt cagtattgtg     836
 Pro Ser Ser Pro Asp Ser Asp Pro 
             160

 ctgaaagaaa cattgatgtg aacccagtga tcagtggaat tgtcaagtac aggtgagcac    896

 ttctgtgttc ccaagaagac agctcatctg gtttcttcct gcatcttggg acactccttc    956

 cctgtctata ccactgactc ttgctctggt tgttgtactc ttatacgtga atagactctt   1016

 aattcagcac ctatagcctt ttgttgtgct tttttgatgt gtctgccttc attagactat   1076

 gatgtctttg agagcaaaga ctatttttcc ttactctttg catattctgc atctgagaca   1136

 ctacttgaaa tatggttggc atcactgaag gttctttgat tcaattaata ttttgtaatc   1196

 accgtgtggc aaaacattcc ccttccaatc tggtgctagt agagtatatg ctatctaggc   1256

 accatgtgtg tggcttttgt gtatcaggtg tttcagaaat atttcaagac agttgtaaga   1316

 tgtttgagga caagaattat tactcctatt tctatgtcat accacacagt agctgcacag   1376

 ttttaagatt atgccatcac ctagggtaat gttttgtaga atcagtcctt cgtgtaacaa   1436

 ctctagtgtt tttgtactgt tgatgatttg cttaaatttt attcaaaaac tatcacttgc   1496

 tataaaggta attgtaaaaa taaatacagt ggacgcaaaa taatgttgtg agtttttata   1556

 aaaataaatt ttaaaatgat atataagaca tttttttgca atgcctgccc taaccacttc   1616

 ttacatgtca tcttaacatc tctttgagga aacactgttt cctcatttta cagatttaac   1676

 atactgtatt atttgatgcc agagccaaca ggctatatca taggcagttt ccaaacttaa   1736

 ttatgccatt tagtttgtct agatttcttt tgcctctctc actgatccat ttggctgtag   1796

 ttttcatccc ttttccagta cacacagcta gctcctcatc ctacctggtt tctgcatatg   1856

 agaatgcaga gggctgagag agggcaaaat tgttgtcatt tagaaaaggc atttaggaaa   1916

 gaggctgcta ttagagggga acacaaagtg aaggtttttt taaaaaagag gacttgca     1974




      <210> 155
      <211> 2808
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (344)..(2689)

      <400> 155
 ccgagatccc gggcacgctg gctctggtga gcgcggcctc cgcggctcct tggccccagg     60

 atgccctctc tcgtggggaa aggagggtcg ggaaaggccg agcgtaggtc caccttctcc    120

 aatccctgcc tgctgggaga ggacgatctc ttgagaaagg aaagacttct gtgctcccga    180

 gaacttccta tcaggtcctg gctgcaggga aacaagctgg gctttttata attaaggttg    240

 gaagaagtca ccacaggcag cagaactcca tcttgagatg aaataacatc tacctggacc    300

 tctggcagaa tttcaaggca cacactgggc tgactctggc gcc  atg atg ttg cct     355
                                                  Met Met Leu Pro
                                                    1

 tat cct tca gca ctg gga gat caa tac tgg gaa gag att ttg ctt cca      403
 Tyr Pro Ser Ala Leu Gly Asp Gln Tyr Trp Glu Glu Ile Leu Leu Pro
   5                  10                  15                  20

 aag aat ggg gaa aat gta gag act atg aag aaa ttg acc caa aat cat      451
 Lys Asn Gly Glu Asn Val Glu Thr Met Lys Lys Leu Thr Gln Asn His
                  25                  30                  35

 aaa gcg aaa ggc ttg cct tct aat gat act gac tgc ccc cag aaa aag      499
 Lys Ala Lys Gly Leu Pro Ser Asn Asp Thr Asp Cys Pro Gln Lys Lys
              40                  45                  50

 gag gga aag gcc caa ata gtg gta cca gtt aca ttc agg gat gtg act      547
 Glu Gly Lys Ala Gln Ile Val Val Pro Val Thr Phe Arg Asp Val Thr
          55                  60                  65

 gtg atc ttc aca gaa gca gaa tgg aag aga ctg agt cca gag cag agg      595
 Val Ile Phe Thr Glu Ala Glu Trp Lys Arg Leu Ser Pro Glu Gln Arg
      70                  75                  80

 aat cta tac aaa gaa gtg atg ctg gag aat tac agg aat ctt ctc tca      643
 Asn Leu Tyr Lys Glu Val Met Leu Glu Asn Tyr Arg Asn Leu Leu Ser
  85                  90                  95                 100

 ttg gaa aac ttt cat tct tca gca gaa cca aag cca gaa atc tac act      691
 Leu Glu Asn Phe His Ser Ser Ala Glu Pro Lys Pro Glu Ile Tyr Thr
                 105                 110                 115

 tgt tcc tcc tgc ctt ctg gcc ttc tcc tgt cag cag ttc ctc agt caa      739
 Cys Ser Ser Cys Leu Leu Ala Phe Ser Cys Gln Gln Phe Leu Ser Gln
             120                 125                 130

 cat gta ctt cag atc ttc ctg ggc tta tgt gca gaa aat cac ttc cat      787
 His Val Leu Gln Ile Phe Leu Gly Leu Cys Ala Glu Asn His Phe His
         135                 140                 145

 cca ggg aat tct agc cca ggg cat tgg aaa cag cag ggg cag cag tat      835
 Pro Gly Asn Ser Ser Pro Gly His Trp Lys Gln Gln Gly Gln Gln Tyr
     150                 155                 160

 tcc cat gta agc tgt tgg ttt gaa aat gca gaa ggt cag gag aga gga      883
 Ser His Val Ser Cys Trp Phe Glu Asn Ala Glu Gly Gln Glu Arg Gly
 165                 170                 175                 180

 ggt ggc tcc aaa ccc tgg tct gca agg aca gag gag aga gaa acc tca      931
 Gly Gly Ser Lys Pro Trp Ser Ala Arg Thr Glu Glu Arg Glu Thr Ser
                 185                 190                 195

 agg gca ttc ccc agc cca ctc caa aga cag tca gca agt cct aga aaa      979
 Arg Ala Phe Pro Ser Pro Leu Gln Arg Gln Ser Ala Ser Pro Arg Lys
             200                 205                 210

 ggc aac atg gtg gta gaa aca gag ccc agc tca gcc caa aga cca aac     1027
 Gly Asn Met Val Val Glu Thr Glu Pro Ser Ser Ala Gln Arg Pro Asn
         215                 220                 225

 cct gtg cag cta gac aaa ggc ttg aag gaa tta gaa acc ttg aga ttt     1075
 Pro Val Gln Leu Asp Lys Gly Leu Lys Glu Leu Glu Thr Leu Arg Phe
     230                 235                 240

 gga gca atc aac tgt aga gag tat gaa ccg gac cat aac ctg gaa tca     1123
 Gly Ala Ile Asn Cys Arg Glu Tyr Glu Pro Asp His Asn Leu Glu Ser
 245                 250                 255                 260

 aac ttt att aca aac ccg agg acc ctc tta ggg aag aag ccc tac att     1171
 Asn Phe Ile Thr Asn Pro Arg Thr Leu Leu Gly Lys Lys Pro Tyr Ile
                 265                 270                 275

 tgc agt gat tgt ggg cga agc ttt aaa gat aga tca acc ctc atc aga     1219
 Cys Ser Asp Cys Gly Arg Ser Phe Lys Asp Arg Ser Thr Leu Ile Arg
             280                 285                 290

 cac cat cgt ata cac tcg atg gag aag cct tat gtg tgc agt gag tgc     1267
 His His Arg Ile His Ser Met Glu Lys Pro Tyr Val Cys Ser Glu Cys
         295                 300                 305

 ggg cga ggt ttt agc cag aag tcc aac ctc agc aga cac cag aga aca     1315
 Gly Arg Gly Phe Ser Gln Lys Ser Asn Leu Ser Arg His Gln Arg Thr
     310                 315                 320

 cat tca gaa gag aag cct tat ttg tgc agg gag tgt ggg caa agc ttt     1363
 His Ser Glu Glu Lys Pro Tyr Leu Cys Arg Glu Cys Gly Gln Ser Phe
 325                 330                 335                 340

 aga agt aag tcc atc ctc aat aga cat cag tgg act cac tca gag gag     1411
 Arg Ser Lys Ser Ile Leu Asn Arg His Gln Trp Thr His Ser Glu Glu
                 345                 350                 355

 aag ccc tat gtt tgc agc gag tgt ggg cga ggc ttt agc gag aag tca     1459
 Lys Pro Tyr Val Cys Ser Glu Cys Gly Arg Gly Phe Ser Glu Lys Ser
             360                 365                 370

 tcc ttc atc aga cac cag agg aca cac tcc ggt gag aaa ccc tat gtg     1507
 Ser Phe Ile Arg His Gln Arg Thr His Ser Gly Glu Lys Pro Tyr Val
         375                 380                 385

 tgc ctg gag tgt gga cga agc ttt tgt gat aag tca acc ctc aga aaa     1555
 Cys Leu Glu Cys Gly Arg Ser Phe Cys Asp Lys Ser Thr Leu Arg Lys
     390                 395                 400

 cac cag agg ata cac tca ggg gag aag cct tat gtt tgc agg gag tgt     1603
 His Gln Arg Ile His Ser Gly Glu Lys Pro Tyr Val Cys Arg Glu Cys
 405                 410                 415                 420

 ggg cga ggc ttt agc cag aac tca gat ctc atc aaa cac cag agg aca     1651
 Gly Arg Gly Phe Ser Gln Asn Ser Asp Leu Ile Lys His Gln Arg Thr
                 425                 430                 435

 cac ttg gat gag aag cct tat gtt tgc agg gag tgt ggg cga ggc ttt     1699
 His Leu Asp Glu Lys Pro Tyr Val Cys Arg Glu Cys Gly Arg Gly Phe
             440                 445                 450

 tgt gac aag tca acc ctc atc ata cac gag cgg acg cac tct gga gag     1747
 Cys Asp Lys Ser Thr Leu Ile Ile His Glu Arg Thr His Ser Gly Glu
         455                 460                 465

 aag cct tat gtg tgt ggt gag tgt ggc cga ggc ttt agt cgg aaa tca     1795
 Lys Pro Tyr Val Cys Gly Glu Cys Gly Arg Gly Phe Ser Arg Lys Ser
     470                 475                 480

 ctc ctc ctt gtc cac cag agg aca cac tca ggg gag aag cat tat gtc     1843
 Leu Leu Leu Val His Gln Arg Thr His Ser Gly Glu Lys His Tyr Val
 485                 490                 495                 500

 tgc agg gag tgt agg cga ggt ttt agc cag aag tca aat ctc atc aga     1891
 Cys Arg Glu Cys Arg Arg Gly Phe Ser Gln Lys Ser Asn Leu Ile Arg
                 505                 510                 515

 cac cag agg acg cac tca aat gag aag cct tat att tgc agg gaa tgt     1939
 His Gln Arg Thr His Ser Asn Glu Lys Pro Tyr Ile Cys Arg Glu Cys
             520                 525                 530

 ggg cga ggc ttt tgt gac aag tca acc ctc att gta cat gag agg aca     1987
 Gly Arg Gly Phe Cys Asp Lys Ser Thr Leu Ile Val His Glu Arg Thr
         535                 540                 545

 cac tca gga gag aag cct tac gtg tgc aga tgt atg ggc aaa gct ttt     2035
 His Ser Gly Glu Lys Pro Tyr Val Cys Arg Cys Met Gly Lys Ala Phe
     550                 555                 560

 gtg atc aca cac cac agg gag aat ctg cat gtg ggg aca ctg tgg agc     2083
 Val Ile Thr His His Arg Glu Asn Leu His Val Gly Thr Leu Trp Ser
 565                 570                 575                 580

 tct gcc cag atg acc ttt tca ggg gta aca ccc cag ctg ctt gag aga     2131
 Ser Ala Gln Met Thr Phe Ser Gly Val Thr Pro Gln Leu Leu Glu Arg
                 585                 590                 595

 aca gtg ttg ctg ctg gca gag atg cat tcc aga gat gca ctc cgc tct     2179
 Thr Val Leu Leu Leu Ala Glu Met His Ser Arg Asp Ala Leu Arg Ser
             600                 605                 610

 gga act cac tct cag cca cag gga gct gca tgc acc aca ggg gca atg     2227
 Gly Thr His Ser Gln Pro Gln Gly Ala Ala Cys Thr Thr Gly Ala Met
         615                 620                 625

 cac ctt tgc agg ggt acc ttc tgg ccc caa ccc ttg act caa cgg gga     2275
 His Leu Cys Arg Gly Thr Phe Trp Pro Gln Pro Leu Thr Gln Arg Gly
     630                 635                 640

 caa ctc cag aag gtc att cca gat cca gag atc ccc atc gaa ctg aag     2323
 Gln Leu Gln Lys Val Ile Pro Asp Pro Glu Ile Pro Ile Glu Leu Lys
 645                 650                 655                 660

 gat cac tgg gtt gca gac aca ttg cag gtc cca ccc ata aat ctc atc     2371
 Asp His Trp Val Ala Asp Thr Leu Gln Val Pro Pro Ile Asn Leu Ile
                 665                 670                 675

 ata atg gca att gaa ttt caa cat gaa ttt tgg agg aga cat tca cac     2419
 Ile Met Ala Ile Glu Phe Gln His Glu Phe Trp Arg Arg His Ser His
             680                 685                 690

 cat agc atc aat tac gca gtg gct cct cag tca ggt ctg atg agg gaa     2467
 His Ser Ile Asn Tyr Ala Val Ala Pro Gln Ser Gly Leu Met Arg Glu
         695                 700                 705

 aag gat gtg cat gtc tgg gag tgt ggg ccc cca ccc ttt gcc aga act     2515
 Lys Asp Val His Val Trp Glu Cys Gly Pro Pro Pro Phe Ala Arg Thr
     710                 715                 720

 gcc cct ata aca cca act tct gat cag aat tgg agg cca ctg agg gaa     2563
 Ala Pro Ile Thr Pro Thr Ser Asp Gln Asn Trp Arg Pro Leu Arg Glu
 725                 730                 735                 740

 aag aag ggt cac tat cag gac ctt tcc act cca tcc cag aag gaa aca     2611
 Lys Lys Gly His Tyr Gln Asp Leu Ser Thr Pro Ser Gln Lys Glu Thr
                 745                 750                 755

 gaa ttg aaa cgt act aga gtt tct ctc aga aga aag aga gat gca aat     2659
 Glu Leu Lys Arg Thr Arg Val Ser Leu Arg Arg Lys Arg Asp Ala Asn
             760                 765                 770

 tct cca ctc cag gac tat ggc ttt ggt gcc t aagaaggaag agttcagttt     2710
 Ser Pro Leu Gln Asp Tyr Gly Phe Gly Ala 
         775                 780

 ttgtgtagag cttatttcca acatgagatg ggtgttcaaa tgcctgcagc atccaaacaa   2770

 gtcctgttaa tgaggggacc agattgggtg gggtgggg                           2808




      <210> 156
      <211> 2764
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (248)..(2302)

      <400> 156
 tttttttatg aggctgggaa aatagaacga ggaagtggtg acgcactggg ctctcacgaa     60

 tacaactaga agctgcaacg actgtgtggc tctatcgatt cgggagaggt ccagaccgga    120

 aatggtcgtt tccatggtaa ccctgagcag gttgcctggg agatgacctc tttcgggtct    180

 ctttgaatct ccgctgtagc gtcacctgga aggcagatct aacagagaac ctggactgtc    240

 tcctatc  atg att ccc ggg aaa tat cgc tct gtt tct ggc cgg gct gcg     289
          Met Ile Pro Gly Lys Tyr Arg Ser Val Ser Gly Arg Ala Ala
            1               5                  10

 aac aac gtg aac tgc ggg ctt cat ctg gtt att caa aca tca tcg ctt      337
 Asn Asn Val Asn Cys Gly Leu His Leu Val Ile Gln Thr Ser Ser Leu
  15                  20                  25                  30

 cct gaa aaa aac aaa gtt gaa ttc aag cta aat aaa gac aca tcg tca      385
 Pro Glu Lys Asn Lys Val Glu Phe Lys Leu Asn Lys Asp Thr Ser Ser
                  35                  40                  45

 ttc ccc ggt aga ctt tta caa cat gac ctt gaa aga aac tac tca agt      433
 Phe Pro Gly Arg Leu Leu Gln His Asp Leu Glu Arg Asn Tyr Ser Ser
              50                  55                  60

 agg caa ggg gat cat att aat ttg gtg agc tca tca ttg tca tca ttt      481
 Arg Gln Gly Asp His Ile Asn Leu Val Ser Ser Ser Leu Ser Ser Phe
          65                  70                  75

 cct att ctt caa cgt tct tct gaa gag aaa att ctt tac tca gac agg      529
 Pro Ile Leu Gln Arg Ser Ser Glu Glu Lys Ile Leu Tyr Ser Asp Arg
      80                  85                  90

 ttg agc cta gaa aga caa aag ctg acc gta tgt cct atc atc aat ggg      577
 Leu Ser Leu Glu Arg Gln Lys Leu Thr Val Cys Pro Ile Ile Asn Gly
  95                 100                 105                 110

 gaa gac cac ctt cgt ttg ttg aac ttt caa cac aat ttt ata act cgg      625
 Glu Asp His Leu Arg Leu Leu Asn Phe Gln His Asn Phe Ile Thr Arg
                 115                 120                 125

 ata caa aat att tct aat cta cag aag tta ata tcg ttg gat tta tat      673
 Ile Gln Asn Ile Ser Asn Leu Gln Lys Leu Ile Ser Leu Asp Leu Tyr
             130                 135                 140

 gat aac cag att gaa gaa att agt ggg ctt tcg act ctg aga tgt ctt      721
 Asp Asn Gln Ile Glu Glu Ile Ser Gly Leu Ser Thr Leu Arg Cys Leu
         145                 150                 155

 cgt gtc ctt ctg ttg ggg aaa aac aga atc aag aaa atc tca aat ctg      769
 Arg Val Leu Leu Leu Gly Lys Asn Arg Ile Lys Lys Ile Ser Asn Leu
     160                 165                 170

 gag aat cta aaa agc tta gat gtc ttg gat ctt cat gga aat cag att      817
 Glu Asn Leu Lys Ser Leu Asp Val Leu Asp Leu His Gly Asn Gln Ile
 175                 180                 185                 190

 acc aaa att gaa aat att aat cat ttg tgt gag ttg aga gtt tta aat      865
 Thr Lys Ile Glu Asn Ile Asn His Leu Cys Glu Leu Arg Val Leu Asn
                 195                 200                 205

 ctt gcc agg aac ttt tta agt cat gtt gat aat ctt aat ggg ctg gat      913
 Leu Ala Arg Asn Phe Leu Ser His Val Asp Asn Leu Asn Gly Leu Asp
             210                 215                 220

 tca cta act gaa ctt aac ttg cga cac aat caa atc act ttc gtg aga      961
 Ser Leu Thr Glu Leu Asn Leu Arg His Asn Gln Ile Thr Phe Val Arg
         225                 230                 235

 gat gtg gat aat ttg ccc tgc ctc caa cat ctc ttt ctc agc ttt aac     1009
 Asp Val Asp Asn Leu Pro Cys Leu Gln His Leu Phe Leu Ser Phe Asn
     240                 245                 250

 aat ata tct agt ttt gac agt gtt tcc tgc ctt gct gac tct tct tcc     1057
 Asn Ile Ser Ser Phe Asp Ser Val Ser Cys Leu Ala Asp Ser Ser Ser
 255                 260                 265                 270

 ctc tcg gac acc acc ttt gat ggc aat ccc ata gct caa gag tca tgg     1105
 Leu Ser Asp Thr Thr Phe Asp Gly Asn Pro Ile Ala Gln Glu Ser Trp
                 275                 280                 285

 tac aaa cac act gtc ctt cag aat atg atg cag ctg cgc cag cta gat     1153
 Tyr Lys His Thr Val Leu Gln Asn Met Met Gln Leu Arg Gln Leu Asp
             290                 295                 300

 atg aag aga atc acg gaa gaa gaa agg cgt atg gca tct gtt tta gcc     1201
 Met Lys Arg Ile Thr Glu Glu Glu Arg Arg Met Ala Ser Val Leu Ala
         305                 310                 315

 aaa aaa gag gaa gag aag aag cgg gaa agt cat aaa caa tct ttg ctt     1249
 Lys Lys Glu Glu Glu Lys Lys Arg Glu Ser His Lys Gln Ser Leu Leu
     320                 325                 330

 aag gag aag aaa agg tta aca att aac aac gta gct cga cag tgg gac     1297
 Lys Glu Lys Lys Arg Leu Thr Ile Asn Asn Val Ala Arg Gln Trp Asp
 335                 340                 345                 350

 ttg caa caa cga gta gcc aat att gct aca aat gaa gat aga aaa gat     1345
 Leu Gln Gln Arg Val Ala Asn Ile Ala Thr Asn Glu Asp Arg Lys Asp
                 355                 360                 365

 tct gac tct cct cag gac ccc tgt cag att gat gga agc acc ctc tct     1393
 Ser Asp Ser Pro Gln Asp Pro Cys Gln Ile Asp Gly Ser Thr Leu Ser
             370                 375                 380

 gca ttc cca gag gaa aca ggg cct cta gac tca gga ctc aac aat gct     1441
 Ala Phe Pro Glu Glu Thr Gly Pro Leu Asp Ser Gly Leu Asn Asn Ala
         385                 390                 395

 tta caa ggt tta tct gtc ata gac aca tac ctt gtt gaa gtg gac ggg     1489
 Leu Gln Gly Leu Ser Val Ile Asp Thr Tyr Leu Val Glu Val Asp Gly
     400                 405                 410

 gat aca ctt tcc cta tat ggc tca gga gca ctg gaa tct ctg gat agg     1537
 Asp Thr Leu Ser Leu Tyr Gly Ser Gly Ala Leu Glu Ser Leu Asp Arg
 415                 420                 425                 430

 aat tgg agt gtt caa aca gca gga atg atc aca aca gtc tcc ttc act     1585
 Asn Trp Ser Val Gln Thr Ala Gly Met Ile Thr Thr Val Ser Phe Thr
                 435                 440                 445

 ttc ata gaa ttt gat gaa atc gtc caa gtg ctt cct aaa ctg aag att     1633
 Phe Ile Glu Phe Asp Glu Ile Val Gln Val Leu Pro Lys Leu Lys Ile
             450                 455                 460

 aag ttt cct aat tct ctg cac ctt aaa ttc aag gaa aca aat ctt gta     1681
 Lys Phe Pro Asn Ser Leu His Leu Lys Phe Lys Glu Thr Asn Leu Val
         465                 470                 475

 atg ctg cag caa ttt aac gca cta gcc caa ctc cgt cgt att gac cag     1729
 Met Leu Gln Gln Phe Asn Ala Leu Ala Gln Leu Arg Arg Ile Asp Gln
     480                 485                 490

 ttg aca att gat cct caa gga aat cca gtt gtc aat ttt aca ctc tgg     1777
 Leu Thr Ile Asp Pro Gln Gly Asn Pro Val Val Asn Phe Thr Leu Trp
 495                 500                 505                 510

 aaa tac tat gta ctg ttt agg cta agc cat ttc agt atg cag aaa ata     1825
 Lys Tyr Tyr Val Leu Phe Arg Leu Ser His Phe Ser Met Gln Lys Ile
                 515                 520                 525

 aat gga aca gag gtg aca cag aat gat atg ata atg gct gaa agg ctc     1873
 Asn Gly Thr Glu Val Thr Gln Asn Asp Met Ile Met Ala Glu Arg Leu
             530                 535                 540

 ttt gga atc cta gca cat gta gca tct tct gag tta ccc cag tat cgt     1921
 Phe Gly Ile Leu Ala His Val Ala Ser Ser Glu Leu Pro Gln Tyr Arg
         545                 550                 555

 ctg att tcc att ctg ggt gat gcc agg aaa aag caa ttt cgg tat cta     1969
 Leu Ile Ser Ile Leu Gly Asp Ala Arg Lys Lys Gln Phe Arg Tyr Leu
     560                 565                 570

 cta gaa tcc aaa gga aaa aaa cct ggt att atc aac gaa gaa aat aat     2017
 Leu Glu Ser Lys Gly Lys Lys Pro Gly Ile Ile Asn Glu Glu Asn Asn
 575                 580                 585                 590

 gac agc aaa aga ctt gta gga gaa aac aca aat cgt gct aca tta aat     2065
 Asp Ser Lys Arg Leu Val Gly Glu Asn Thr Asn Arg Ala Thr Leu Asn
                 595                 600                 605

 tat act aca aga gac ttt tat aat gaa aag cta gag gaa ata aag gaa     2113
 Tyr Thr Thr Arg Asp Phe Tyr Asn Glu Lys Leu Glu Glu Ile Lys Glu
             610                 615                 620

 aag aag aaa ttc tgt aaa aca tat ata gaa gac ctt gtg aag gaa gcc     2161
 Lys Lys Lys Phe Cys Lys Thr Tyr Ile Glu Asp Leu Val Lys Glu Ala
         625                 630                 635

 aca gaa atc aac atg aaa aat gag gct ttg cag aag ctt tgg cca cag     2209
 Thr Glu Ile Asn Met Lys Asn Glu Ala Leu Gln Lys Leu Trp Pro Gln
     640                 645                 650

 atg ttc att gag ctc gtt agg gat gca gtc ata gaa att cgc aat aaa     2257
 Met Phe Ile Glu Leu Val Arg Asp Ala Val Ile Glu Ile Arg Asn Lys
 655                 660                 665                 670

 aat tcc tat atg aag ctc tgc cta cag cag ata aca gac caa aaa taa     2305
 Asn Ser Tyr Met Lys Leu Cys Leu Gln Gln Ile Thr Asp Gln Lys 
                 675                 680                 685

 aaatggcctt tagttacagt tgattttggc agttttattt tttgaaggtt gaaaatatgc   2365

 aggttataca tgttaaaaca acaacaacac tatcctataa actagaaaga ctagtataaa   2425

 agcattattg cccactgttc tcatagctaa aagttaagaa ggaaagaagg aaagcaggag   2485

 aaaggaagga ttaattgcct gtatgtgagg accaaacaac ctttgggaac taaacagttt   2545

 tcagagatgg cgtggcactg catccttggt tcttgctttg attggtgccc tgctatagcc   2605

 caaagcacgt agtatttgct gatgattcag catgagctgc atctacctac ttttagctga   2665

 taattttcag ttatttccct ttttatttta tgtcatgatt tcaaagccaa aaatatgttc   2725

 tttttatgag tgaagaataa acttactaac aaattagtc                          2764




      <210> 157
      <211> 1116
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (55)..(465)

      <400> 157
 ctgcccgggc cgtggcagga agccggaagc agccgcggcc ccagttcggg agac  atg      57
                                                              Met
                                                                1

 gcg ggc gtt aaa gct ctc gtg gca tta tcc ttc agt ggg gct att gga      105
 Ala Gly Val Lys Ala Leu Val Ala Leu Ser Phe Ser Gly Ala Ile Gly
               5                  10                  15

 ctg act ttt ctt atg ctg gga tgt gcc tta gag gat tat ggc ctg ggt      153
 Leu Thr Phe Leu Met Leu Gly Cys Ala Leu Glu Asp Tyr Gly Leu Gly
          20                  25                  30

 cca act gac agc gtt tac tgg ccc tta ttc gtc ctg att ttc cac gcc      201
 Pro Thr Asp Ser Val Tyr Trp Pro Leu Phe Val Leu Ile Phe His Ala
      35                  40                  45

 atc tcc ccc atc ccc cat ttc att gcc aaa aga gtc acc tat gac tca      249
 Ile Ser Pro Ile Pro His Phe Ile Ala Lys Arg Val Thr Tyr Asp Ser
  50                  55                  60                  65

 gat gca acc agt agt gcc tgt cgg gaa ctg gca tat ttc ttc act act      297
 Asp Ala Thr Ser Ser Ala Cys Arg Glu Leu Ala Tyr Phe Phe Thr Thr
                  70                  75                  80

 gga att gtt gtt tct gcc ttt gga ttt cct gtt att ctt gct cgt gtg      345
 Gly Ile Val Val Ser Ala Phe Gly Phe Pro Val Ile Leu Ala Arg Val
              85                  90                  95

 gct gtg atc aaa tgg gga gcc tgc ggc ctt gtg ttg gca ggc aat gca      393
 Ala Val Ile Lys Trp Gly Ala Cys Gly Leu Val Leu Ala Gly Asn Ala
         100                 105                 110

 gtc att ttc ctt aca att caa ggg ttt ttc ctt ata ttt gga aga gga      441
 Val Ile Phe Leu Thr Ile Gln Gly Phe Phe Leu Ile Phe Gly Arg Gly
     115                 120                 125

 gat gat ttt agc tgg gag cag tgg tagcacttta ttctgattac agtgcattga     495
 Asp Asp Phe Ser Trp Glu Gln Trp 
 130                 135

 atttcttaga actcatacta tctgtataca tgtgcacatg cggcatttta ctatgaaatt    555

 taatatgctg ggttttttaa tacctttata tatcatgttc actttaagaa agacttcata    615

 agtaggagat gagttttatt ctcagcaaat agacctgtca aatttagatt atgttactca    675

 aattatgtta cttgtttggc tgttcatgta gtcacggtgc tctcagaaaa tatattaacg    735

 cagtcttgta ggcagctgcc accttatgca gtgcatcgaa accttttgct tggggatgtg    795

 cttggagagg cagataacgc tgaagcaggc ctctcatgac ccaggaaggc cggggtggat    855

 ccctctttgt gttgtagtcc atgctattaa aagtgtggcc cacagaccaa gagcctcaac    915

 atttcctaga gccttattag aaatgcagaa tctgaagccc cactctggac ccaggacatt    975

 ttgatgagat ccaaaggagt tgtatgcaca tgaaagtttg agaagcatca tcatagagaa   1035

 gtaaacatca cacccaactt ccttatcttt ccagtggcta aaccacttaa cctctctggg   1095

 tgttacctgc tcatttgttt a                                             1116




      <210> 158
      <211> 2545
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (350)..(949)

      <400> 158
 gttattatcc ccatatttaa aatggaggaa ggccagagag gtaaagtggc ttatcctagg     60

 acacccagct agtgaaggcc accagagcca ggatgcctga ttctaagtca agagaatttc    120

 taccacccca cactggcagc cgaaggaggc aggcagggca gcaaacaggc agtttccttc    180

 cttctctccc tggaaagatg acagccgtga cgccagtcct cctgagcccg ccagccccac    240

 catcggcctc gataagaaga ctcgccgaaa gttcctggac ctgggggtca ccctgcgccg    300

 agcatccacg ggcaagagcc ggaaggagaa aggcagcaac cgactgtcc    atg ggc     355
                                                          Met Gly
                                                            1

 agc agg gag tca gtg gag ggg tcc ggc agg tca ggg ggc tcc ccg ttc      403
 Ser Arg Glu Ser Val Glu Gly Ser Gly Arg Ser Gly Gly Ser Pro Phe
           5                  10                  15

 ctg cct ttt tcc tgg ttc acg gac agc ggc aag ggc tca gca tcc tcg      451
 Leu Pro Phe Ser Trp Phe Thr Asp Ser Gly Lys Gly Ser Ala Ser Ser
      20                  25                  30

 ggt agc acc acc tcc ccc acc tgc tcc cct aaa cac gag ggc ttc agc      499
 Gly Ser Thr Thr Ser Pro Thr Cys Ser Pro Lys His Glu Gly Phe Ser
  35                  40                  45                  50

 cct aag aag tca gct tcc cag gaa tcc act ctg agt gat gac tcc acg      547
 Pro Lys Lys Ser Ala Ser Gln Glu Ser Thr Leu Ser Asp Asp Ser Thr
                  55                  60                  65

 ccc ccc agc agc agc ccc aag atc ccc agt ggg ccc tgg cag gag gcc      595
 Pro Pro Ser Ser Ser Pro Lys Ile Pro Ser Gly Pro Trp Gln Glu Ala
              70                  75                  80

 aaa tgt tct tac ccc tac cac acg ctg tct cag tct tca gat gag ttc      643
 Lys Cys Ser Tyr Pro Tyr His Thr Leu Ser Gln Ser Ser Asp Glu Phe
          85                  90                  95

 ctg gat gaa ccc ctc ccc cct gtc cac cac tgg acc agc cag cag gtg      691
 Leu Asp Glu Pro Leu Pro Pro Val His His Trp Thr Ser Gln Gln Val
     100                 105                 110

 ggc cag tgg ctg cag agc ctc aac ctg gaa cag tat gct gct gag ttt      739
 Gly Gln Trp Leu Gln Ser Leu Asn Leu Glu Gln Tyr Ala Ala Glu Phe
 115                 120                 125                 130

 gct gca cgg cag gta gac ggg ccg cag ctg ctg cag ctg gac gga agc      787
 Ala Ala Arg Gln Val Asp Gly Pro Gln Leu Leu Gln Leu Asp Gly Ser
                 135                 140                 145

 aaa cta aag agc ctg ggg ctc agc aac tct cat gac cgg gca ctg gtg      835
 Lys Leu Lys Ser Leu Gly Leu Ser Asn Ser His Asp Arg Ala Leu Val
             150                 155                 160

 aag cgc aag ttg aag gag atg gca gca gct gcc gag aag gag cgc aag      883
 Lys Arg Lys Leu Lys Glu Met Ala Ala Ala Ala Glu Lys Glu Arg Lys
         165                 170                 175

 gcc cag gag aag gct gcg cgg cag cgg gag aag ctc cgg cgc cga gag      931
 Ala Gln Glu Lys Ala Ala Arg Gln Arg Glu Lys Leu Arg Arg Arg Glu
     180                 185                 190

 cag gag gcc aag aag agc tagggg agggtgcaca ggcgctggca cccggcaggg      985
 Gln Glu Ala Lys Lys Ser 
 195                 200

 gcagccactg gctccgcggg cacaggcctc accagggagg ctggacctgg gcgctgcact   1045

 tgggctagcc tggtcccacg ctctcagggg ggacatgctc tctcttaccc tgtcacttgg   1105

 tctagaccca gagaccccag aaagggagac cccagggaga gggcctagta ataaatccta   1165

 ttttgaggac ttgtttggca cagagttcct gggggaggag cagatgaagg ggagagggca   1225

 gagaggccag ggctgaggca agtctgggag cctgggtcag gctgtcccat tgccctcagg   1285

 ccatcatggg gctggggtgg aggggagcta ggaggcctgc ctgcctgctt gcctgccaga   1345

 ggccctgagg ccgggcccca gggctcagag ctgggctggg catttcagca ggagcccatg   1405

 tgggagcggc tcctctccac tcttccaggg ggctgtgtgg tgggagagct ctgtcctgct   1465

 cccccaagag gccagtgggc gctgcagcaa gtcgcactca gggtagactc ccagccaaac   1525

 tcctcaacag gagcgcagag aaagcagcct ggggcgagtg cagtctttgc caggactcaa   1585

 gaggggagga tgaacatccc cttctccctc tcccctcctc tgtcctgtgg gtcccagggg   1645

 gcgagatgac accacacagg tctgcctctc agggcccatt caagacctgg tctttgaccc   1705

 attctccaag ccaggactcc cttcacttcc tgctgcttcc tcagagggca cctaagtcct   1765

 ctttgggagc tgagcaaaca ggaactgata gggacagagg acaccacttc caccagccaa   1825

 ggcctaggag ctgctgacct ggtcagccct caccccagcc aggcagagag gcaaaacctg   1885

 ggggtccccg gcagctacga gattggaaag gttcatcagc cctcccccat ctgccccagg   1945

 cattgtcagg gaatcagtgg gctcagaact ggcaggcggt gcaagctctg cttccctggg   2005

 ccacactgag ggctggggcc agctccctgg atgggggtgg agtttaccag cagcctgggg   2065

 acagcatgtg tcctttttag gaaatgtcct tggaggaagt gttcatgtgt ggcgctggtc   2125

 agcagctagt cccgcttcca ggacactggt cagagttacc gatgaggcct gggggctccc   2185

 gcttggaaac ccctccagct cctcccatct gcccagacag agcggcagat ggcaccaatg   2245

 catgctggct ccctcattcc tgcccagggg ctgtggctta cggccagcac cctgtacctg   2305

 ggactcagcc cttatccccc ctctgctatc tgtgctggga gaggggcttc ggagggaaac   2365

 agatatgagg acactggcac catctgggcc tggtggcagg gccatgggag gttggaaggc   2425

 acccacatcc ttaaagccat cagtagctct agtgggtgcc cacctgcatg tgaaggggag   2485

 gcagttctca atttatttca ataaatcctt atgatgtgcc agtgaccaaa aaaaaaaaaa   2545




      <210> 159
      <211> 1555
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (936)..(1055)

      <400> 159
 agcggcacga gcacagctgt tggtttctga gcagcatgga gtcacactgg ttcctcctgg     60

 cctgagggga aagagagaca gagagagatc aacctggatg ccttccttca caataatctc    120

 atggaggtaa tttaaagaat cctttttttg gagagtcaga gagaaaagca aaaaaaaaga    180

 gcatgaggaa tttgaagact gagagatgag ttgtgtagca ccaacatttt ctttctgcct    240

 gaccttcata cctgatgaat taaaagcata ggatgtttgg aagagtgaga taagggacac    300

 attgaaaaca gagaggcaat ctgaaggcta ccttgacgca tctgcaaagc tcccagattc    360

 tgactttcac aagacttgct ttctgtttct gggcctcgcc taaacagact gccagtcatc    420

 cgaaccgtgg caggatggag atgtttgtgt aaggtagact caagtttgca agactcaaga    480

 aggaaaccac caaactaatt ttactttcac ttaaaccaga ttgaaaccaa gacttgaaga    540

 attaaaaact ttgacattaa ccattgattc actccaatga aataattgtg ttatagccag    600

 aatcatggtg aaattggaac aaggcttttg atgggatttt taattgaggg acttatatta    660

 aattggatat tttctttaat gaacagcatg tggccaaaat tctattttca ttaaagtata    720

 ttaagcatca tgacaactca tattaaacct gcaacaaatg attaatgaca tttagagact    780

 tcaaatgtca tgagacacct taaatattaa gaatcaaaaa gaacacctca aagttgtttc    840

 tattcttagt aattatgctt aaaaaaacat ctttccttgc tttgaaagcc agttgctaaa    900

 aataaaaact gttccatgaa aaatcacaat gccca   atg ata aat tta tgt att     953
                                          Met Ile Asn Leu Cys Ile
                                            1               5

 tgt ttt tta aag ggg gag gat ggt gag aaa aat aga aag ctc ctg gct     1001
 Cys Phe Leu Lys Gly Glu Asp Gly Glu Lys Asn Arg Lys Leu Leu Ala
              10                  15                  20

 gac atc aga ggt cac aag atg agt tcc tca ttt gtc caa atg aca ttc     1049
 Asp Ile Arg Gly His Lys Met Ser Ser Ser Phe Val Gln Met Thr Phe
          25                  30                  35

 agc tgc taaaagaagt cagactttta gagggctgtt gaaaagacag taagtcagga      1105
 Ser Cys 
      40

 ggttttcagt acatgactgc aggggaatca gacacaggct agtcacttaa gttgcttaat   1165

 tgtccgtgta cccttagccc acgacttcag ggctcagcag cttcatcctt catggcacca   1225

 aaccttgacg taagggattc aaagacacac tcataagaat cgtgaatttg tcctcatgca   1285

 aaatttgggg gactggctac aaaaccgaaa caaggagatc gtatccctaa gtgaaaggga   1345

 ctttatatta attgtcagtt ataacaatat gtaaaataca taaaagagat agagcactgc   1405

 aggccatcaa ggtcaaacat ttgaaacaga attaaactaa attataagga ggattaaatg   1465

 gcttttgtct ttgtaaagaa aagaatatgc atgcattgat tgcctatgta gaaggattaa   1525

 taaatctttt ggcatggtaa aaaaaaaaaa                                    1555




      <210> 160
      <211> 2612
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (64)..(2559)

      <400> 160
 acctttgagg aagctgataa gaatggtgac ggcttgctga atattgaaga gatacatcag     60

 ctg  atg cat aaa ctg aat gtt aat ctg ccc cga aga aaa gtc aga caa     108
      Met His Lys Leu Asn Val Asn Leu Pro Arg Arg Lys Val Arg Gln
        1               5                  10                  15

 atg ttt cag gaa gcc gac aca gat gag aat cag gga act ttg aca ttt      156
 Met Phe Gln Glu Ala Asp Thr Asp Glu Asn Gln Gly Thr Leu Thr Phe
                  20                  25                  30

 gaa gag ttc tgt gtt ttt tac aaa atg atg tct ttg aga cga gac ctt      204
 Glu Glu Phe Cys Val Phe Tyr Lys Met Met Ser Leu Arg Arg Asp Leu
              35                  40                  45

 tat ttg tta ctt ttg agc tac agt gac aag aaa gat cac cta act gtg      252
 Tyr Leu Leu Leu Leu Ser Tyr Ser Asp Lys Lys Asp His Leu Thr Val
          50                  55                  60

 gaa gaa ctg gct cag ttt ttg aag gtg gag caa aag atg aat aat gtg      300
 Glu Glu Leu Ala Gln Phe Leu Lys Val Glu Gln Lys Met Asn Asn Val
      65                  70                  75

 aca acg gac tat tgt ctt gac atc ata aag aag ttt gaa gtt tca gaa      348
 Thr Thr Asp Tyr Cys Leu Asp Ile Ile Lys Lys Phe Glu Val Ser Glu
  80                  85                  90                  95

 gaa aat aag gtg aaa aat gtt ctt ggc ata gaa ggc ttc acg aac ttc      396
 Glu Asn Lys Val Lys Asn Val Leu Gly Ile Glu Gly Phe Thr Asn Phe
                 100                 105                 110

 atg cgt agt cct gcc tgt gac ata ttt aac cca ttg cac cat gaa gtg      444
 Met Arg Ser Pro Ala Cys Asp Ile Phe Asn Pro Leu His His Glu Val
             115                 120                 125

 tac caa gac atg gat cag ccc ctc tgc aac tac tac att gct tcc tct      492
 Tyr Gln Asp Met Asp Gln Pro Leu Cys Asn Tyr Tyr Ile Ala Ser Ser
         130                 135                 140

 cac aat aca tac ctg act gga gac cag ctc ctt tct cag tcc aaa gtg      540
 His Asn Thr Tyr Leu Thr Gly Asp Gln Leu Leu Ser Gln Ser Lys Val
     145                 150                 155

 gat atg tat gca cgg gtg ctg caa gag ggc tgt cgc tgt gtg gaa gtt      588
 Asp Met Tyr Ala Arg Val Leu Gln Glu Gly Cys Arg Cys Val Glu Val
 160                 165                 170                 175

 gac tgt tgg gat ggc cca gat gga gag cca gta gta cat cat ggt tac      636
 Asp Cys Trp Asp Gly Pro Asp Gly Glu Pro Val Val His His Gly Tyr
                 180                 185                 190

 act ctc act tca aaa att ctc ttc aga gat gtt gtg gag acc atc aac      684
 Thr Leu Thr Ser Lys Ile Leu Phe Arg Asp Val Val Glu Thr Ile Asn
             195                 200                 205

 aag cat gcc ttt gtg aag aat gag ttt cct gtt ata ttg tct atc gag      732
 Lys His Ala Phe Val Lys Asn Glu Phe Pro Val Ile Leu Ser Ile Glu
         210                 215                 220

 aat cac tgc agt atc cag cag caa agg aag att gct cag tac ctg aaa      780
 Asn His Cys Ser Ile Gln Gln Gln Arg Lys Ile Ala Gln Tyr Leu Lys
     225                 230                 235

 gga ata ttc gga gac aaa ctg gac ctg tca tct gtt gat aca ggg gag      828
 Gly Ile Phe Gly Asp Lys Leu Asp Leu Ser Ser Val Asp Thr Gly Glu
 240                 245                 250                 255

 tgc aag cag ctt cca agc cct caa agt ttg aaa ggc aaa att cta gtg      876
 Cys Lys Gln Leu Pro Ser Pro Gln Ser Leu Lys Gly Lys Ile Leu Val
                 260                 265                 270

 aag ggt aag aag ttg cct tat cac ctt ggg gat gat gca gag gaa ggg      924
 Lys Gly Lys Lys Leu Pro Tyr His Leu Gly Asp Asp Ala Glu Glu Gly
             275                 280                 285

 gaa gtt tcc gat gag gac agt gca gat gaa att gaa gac gag tgc aaa      972
 Glu Val Ser Asp Glu Asp Ser Ala Asp Glu Ile Glu Asp Glu Cys Lys
         290                 295                 300

 ttc aag ctc cat tat agt aat ggg acc act gag cat cag gtg gaa tct     1020
 Phe Lys Leu His Tyr Ser Asn Gly Thr Thr Glu His Gln Val Glu Ser
     305                 310                 315

 ttc ata agg aaa aaa ctg gag tca ctg tta aaa gaa tct caa att cga     1068
 Phe Ile Arg Lys Lys Leu Glu Ser Leu Leu Lys Glu Ser Gln Ile Arg
 320                 325                 330                 335

 gat aaa gaa gat cct gat agt ttc aca gtg cgg gca cta ctg aag gcc     1116
 Asp Lys Glu Asp Pro Asp Ser Phe Thr Val Arg Ala Leu Leu Lys Ala
                 340                 345                 350

 acg cat gaa ggc tta aat gca cac ctg aag cag agt cca gat gta aag     1164
 Thr His Glu Gly Leu Asn Ala His Leu Lys Gln Ser Pro Asp Val Lys
             355                 360                 365

 gaa agt gga aag aaa tca cat gga cga tcc ctc atg acc aac ttt gga     1212
 Glu Ser Gly Lys Lys Ser His Gly Arg Ser Leu Met Thr Asn Phe Gly
         370                 375                 380

 aaa cat aag aaa act aca aaa tca cgg tct aaa tct tac agt act gat     1260
 Lys His Lys Lys Thr Thr Lys Ser Arg Ser Lys Ser Tyr Ser Thr Asp
     385                 390                 395

 gat gag gaa gac aca cag cag agt act ggc aag gag ggt ggc cag ctg     1308
 Asp Glu Glu Asp Thr Gln Gln Ser Thr Gly Lys Glu Gly Gly Gln Leu
 400                 405                 410                 415

 tac aga ttg ggt cgc cga agg aaa acc atg aag ctc tgc cga gaa ctc     1356
 Tyr Arg Leu Gly Arg Arg Arg Lys Thr Met Lys Leu Cys Arg Glu Leu
                 420                 425                 430

 tct gat ttg gtt gtg tac aca aac tcc gtg gcc gct cag gac att gtg     1404
 Ser Asp Leu Val Val Tyr Thr Asn Ser Val Ala Ala Gln Asp Ile Val
             435                 440                 445

 gat gac gga acc aca gga aat gtg tta tca ttc agt gaa aca aga gca     1452
 Asp Asp Gly Thr Thr Gly Asn Val Leu Ser Phe Ser Glu Thr Arg Ala
         450                 455                 460

 cat cag gtt gtt cag caa aaa tca gag cag ttc atg att tat aat caa     1500
 His Gln Val Val Gln Gln Lys Ser Glu Gln Phe Met Ile Tyr Asn Gln
     465                 470                 475

 aag caa ctc acg agg att tac ccc tct gcc tac cgc att gat tcc agt     1548
 Lys Gln Leu Thr Arg Ile Tyr Pro Ser Ala Tyr Arg Ile Asp Ser Ser
 480                 485                 490                 495

 aac ttc aac cct ctc ccc tac tgg aac gca ggc tgc cag cta gtg gca     1596
 Asn Phe Asn Pro Leu Pro Tyr Trp Asn Ala Gly Cys Gln Leu Val Ala
                 500                 505                 510

 ctg aat tat caa tct gaa gga cga atg atg cag tta aac cga gcc aaa     1644
 Leu Asn Tyr Gln Ser Glu Gly Arg Met Met Gln Leu Asn Arg Ala Lys
             515                 520                 525

 ttc aag gca aat ggc aat tgt ggc tat gtc ctc aaa ccc cag caa atg     1692
 Phe Lys Ala Asn Gly Asn Cys Gly Tyr Val Leu Lys Pro Gln Gln Met
         530                 535                 540

 tgc aaa ggt act ttc aac cct ttc tct ggt gac cct ctt cct gcc aac     1740
 Cys Lys Gly Thr Phe Asn Pro Phe Ser Gly Asp Pro Leu Pro Ala Asn
     545                 550                 555

 ccc aaa aag cag ctc atc ctg aaa gtt atc agt gga cag caa ctc ccc     1788
 Pro Lys Lys Gln Leu Ile Leu Lys Val Ile Ser Gly Gln Gln Leu Pro
 560                 565                 570                 575

 aaa cct cca gac tcc atg ttt gga gat cga ggc gag atc att gac cct     1836
 Lys Pro Pro Asp Ser Met Phe Gly Asp Arg Gly Glu Ile Ile Asp Pro
                 580                 585                 590

 ttt gtt gaa gtt gaa att att gga ttg cca gta gat tgt tgt aaa gat     1884
 Phe Val Glu Val Glu Ile Ile Gly Leu Pro Val Asp Cys Cys Lys Asp
             595                 600                 605

 caa acc cgt gtg gta gat gac aat gga ttt aac cct gtg tgg gaa gaa     1932
 Gln Thr Arg Val Val Asp Asp Asn Gly Phe Asn Pro Val Trp Glu Glu
         610                 615                 620

 aca ctg aca ttt aca gta cac atg cca gaa ata gct ttg gtt cgg ttc     1980
 Thr Leu Thr Phe Thr Val His Met Pro Glu Ile Ala Leu Val Arg Phe
     625                 630                 635

 ctt gtg tgg gat cac gat ccc att gga cga gac ttt gtt gga caa aga     2028
 Leu Val Trp Asp His Asp Pro Ile Gly Arg Asp Phe Val Gly Gln Arg
 640                 645                 650                 655

 act gtg acc ttc agc agc tta gtg cct ggc tac cgg cat gtc tat ttg     2076
 Thr Val Thr Phe Ser Ser Leu Val Pro Gly Tyr Arg His Val Tyr Leu
                 660                 665                 670

 gaa gga ctg aca gaa gca tcc ata ttt gta cac ata acc atc aat gaa     2124
 Glu Gly Leu Thr Glu Ala Ser Ile Phe Val His Ile Thr Ile Asn Glu
             675                 680                 685

 atc tat gga aag tgg agc cct tta ata ctc aac ccc agt tat act ata     2172
 Ile Tyr Gly Lys Trp Ser Pro Leu Ile Leu Asn Pro Ser Tyr Thr Ile
         690                 695                 700

 ttg cac ttt cta gga gct aca aag aac aga caa ctc cag ggt ctg aag     2220
 Leu His Phe Leu Gly Ala Thr Lys Asn Arg Gln Leu Gln Gly Leu Lys
     705                 710                 715

 gga ctg ttc aat aag aat cct agg cac agt tct tca gaa aac aat tcc     2268
 Gly Leu Phe Asn Lys Asn Pro Arg His Ser Ser Ser Glu Asn Asn Ser
 720                 725                 730                 735

 cat tat gta cgg aag cga tcc att gga gat aga att ctg cga cgc aca     2316
 His Tyr Val Arg Lys Arg Ser Ile Gly Asp Arg Ile Leu Arg Arg Thr
                 740                 745                 750

 gct agc gcc cca gcc aaa ggc agg aaa aag agc aaa atg ggc ttc caa     2364
 Ala Ser Ala Pro Ala Lys Gly Arg Lys Lys Ser Lys Met Gly Phe Gln
             755                 760                 765

 gaa atg gtg gag ata aag gat tct gtg tcc gag gcc aca aga gat caa     2412
 Glu Met Val Glu Ile Lys Asp Ser Val Ser Glu Ala Thr Arg Asp Gln
         770                 775                 780

 gat ggc gtg ctg agg agg acc aca cgc agt ttg caa gca cgc cct gtc     2460
 Asp Gly Val Leu Arg Arg Thr Thr Arg Ser Leu Gln Ala Arg Pro Val
     785                 790                 795

 tct atg cct gtt gac aga aac ctt ctg gga gct ttg tcg ctg cct gta     2508
 Ser Met Pro Val Asp Arg Asn Leu Leu Gly Ala Leu Ser Leu Pro Val
 800                 805                 810                 815

 tct gaa aca gca aaa gac att gaa gga aaa gaa aac tct cta gta caa     2556
 Ser Glu Thr Ala Lys Asp Ile Glu Gly Lys Glu Asn Ser Leu Val Gln
                 820                 825                 830

 atc tgaataggaa acaacttaag cagaagataa agatggcaga agaaaaggga aag      2612
 Ile 






      <210> 161
      <211> 2193
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2190)

      <400> 161
  atg cct gaa cct ccc ccc gcc cca ggc tcc tgc gca gcc cga gcc tcc      48
  Met Pro Glu Pro Pro Pro Ala Pro Gly Ser Cys Ala Ala Arg Ala Ser
    1               5                  10                  15

 aag acg agc gcc gct cct ggc tcc acg gcg ccc agt ccc atc cac cgt       96
 Lys Thr Ser Ala Ala Pro Gly Ser Thr Ala Pro Ser Pro Ile His Arg
              20                  25                  30

 tca agg gct gag gag cgt ggg acc acg gcg cgg aac tgg cag gca gct      144
 Ser Arg Ala Glu Glu Arg Gly Thr Thr Ala Arg Asn Trp Gln Ala Ala
          35                  40                  45

 cca act gca gcc ccg gtg cgg gat cca ctg ggt gaa gcc agc tgg gct      192
 Pro Thr Ala Ala Pro Val Arg Asp Pro Leu Gly Glu Ala Ser Trp Ala
      50                  55                  60

 cct gag tct gct aat cta gtg gga atc tgg aga act ttt gtg tct agc      240
 Pro Glu Ser Ala Asn Leu Val Gly Ile Trp Arg Thr Phe Val Ser Ser
  65                  70                  75                  80

 tca ggg att gta aat gca cca atc agc acc ctg tca aaa cgg acc aat      288
 Ser Gly Ile Val Asn Ala Pro Ile Ser Thr Leu Ser Lys Arg Thr Asn
                  85                  90                  95

 cag ctc tct gta aaa cag acc aat cgg ctc tct gta aaa tgg acc aat      336
 Gln Leu Ser Val Lys Gln Thr Asn Arg Leu Ser Val Lys Trp Thr Asn
             100                 105                 110

 cag cag gat gtg gcc cgt ggc tcg gcg act tac agg gag gga gaa cat      384
 Gln Gln Asp Val Ala Arg Gly Ser Ala Thr Tyr Arg Glu Gly Glu His
         115                 120                 125

 ggc tgc tgg ctt tta gca cct ggt ggg ttt cgc gcc ttg caa ctc gac      432
 Gly Cys Trp Leu Leu Ala Pro Gly Gly Phe Arg Ala Leu Gln Leu Asp
     130                 135                 140

 aac tgc cgg gac gga gtc tgg ctg ccc gac ccc ctg cgg cag gtg ctg      480
 Asn Cys Arg Asp Gly Val Trp Leu Pro Asp Pro Leu Arg Gln Val Leu
 145                 150                 155                 160

 ggc gag gcg cct ccc ctg caa cta gcc tgc cgc ttc cct tcc ggc acc      528
 Gly Glu Ala Pro Pro Leu Gln Leu Ala Cys Arg Phe Pro Ser Gly Thr
                 165                 170                 175

 ccc gcc gcc agc ccc gag cgc gga cct gga gcg gag aag aga gtg tgc      576
 Pro Ala Ala Ser Pro Glu Arg Gly Pro Gly Ala Glu Lys Arg Val Cys
             180                 185                 190

 gga aag gat gta tca gaa gta acc cac tgc aca cat gat ctc tta cat      624
 Gly Lys Asp Val Ser Glu Val Thr His Cys Thr His Asp Leu Leu His
         195                 200                 205

 gct aca tta gaa gac tcc tgg gat gtt agc agc cag tta gac agg caa      672
 Ala Thr Leu Glu Asp Ser Trp Asp Val Ser Ser Gln Leu Asp Arg Gln
     210                 215                 220

 cag gaa aac tgg aag aga cat ctg gga tca gag gca tcc acc cag aag      720
 Gln Glu Asn Trp Lys Arg His Leu Gly Ser Glu Ala Ser Thr Gln Lys
 225                 230                 235                 240

 aaa ata att aca cca caa gaa aat ttt gag caa aat aaa ttt ggt gaa      768
 Lys Ile Ile Thr Pro Gln Glu Asn Phe Glu Gln Asn Lys Phe Gly Glu
                 245                 250                 255

 aat tct aga ttg aac acc aat ttg gtt aca caa ctg aac att cct gca      816
 Asn Ser Arg Leu Asn Thr Asn Leu Val Thr Gln Leu Asn Ile Pro Ala
             260                 265                 270

 aga ata agg cct agt gaa tgt gag acc ctt gga agc aat ttg gga cat      864
 Arg Ile Arg Pro Ser Glu Cys Glu Thr Leu Gly Ser Asn Leu Gly His
         275                 280                 285

 aat gca gac tta ctt aat gag aat aat att ctt gca aaa aag aaa ccc      912
 Asn Ala Asp Leu Leu Asn Glu Asn Asn Ile Leu Ala Lys Lys Lys Pro
     290                 295                 300

 tat aag tgt gat aaa tgt aga aaa gcc ttt att cat aga tca tcg ctt      960
 Tyr Lys Cys Asp Lys Cys Arg Lys Ala Phe Ile His Arg Ser Ser Leu
 305                 310                 315                 320

 act aaa cat gag aaa aca cat aaa gga gag gga gct ttc cct aat gga     1008
 Thr Lys His Glu Lys Thr His Lys Gly Glu Gly Ala Phe Pro Asn Gly
                 325                 330                 335

 aca gat caa gga att tat cct gga aag aaa cac cat gaa tgt acc gac     1056
 Thr Asp Gln Gly Ile Tyr Pro Gly Lys Lys His His Glu Cys Thr Asp
             340                 345                 350

 tgt ggg aaa acc ttt ctc tgg aag aca cag ctt act gag cat cag aga     1104
 Cys Gly Lys Thr Phe Leu Trp Lys Thr Gln Leu Thr Glu His Gln Arg
         355                 360                 365

 att cac act ggg gag aaa ccc ttt gaa tgc aat gta tgt gga aag gcc     1152
 Ile His Thr Gly Glu Lys Pro Phe Glu Cys Asn Val Cys Gly Lys Ala
     370                 375                 380

 ttc agg cat agc tca tct ctt ggt cag cat gag aat gct cat acc gga     1200
 Phe Arg His Ser Ser Ser Leu Gly Gln His Glu Asn Ala His Thr Gly
 385                 390                 395                 400

 gag aaa ccc tat cag tgt agt ctc tgt ggg aaa gcc ttc cag cgc agc     1248
 Glu Lys Pro Tyr Gln Cys Ser Leu Cys Gly Lys Ala Phe Gln Arg Ser
                 405                 410                 415

 tcc tcc ctt gtt caa cac cag cga att cac act gga gag aaa ccc tat     1296
 Ser Ser Leu Val Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr
             420                 425                 430

 cga tgt aat cta tgt ggg agg tcc ttt agg cat ggc aca tcc ctc act     1344
 Arg Cys Asn Leu Cys Gly Arg Ser Phe Arg His Gly Thr Ser Leu Thr
         435                 440                 445

 caa cac gag gtc aca cac agt gga gag aag ccc ttc cag tgt aag gaa     1392
 Gln His Glu Val Thr His Ser Gly Glu Lys Pro Phe Gln Cys Lys Glu
     450                 455                 460

 tgt ggg aaa gcc ttt agt cga tgt tct tcc ctt gtc caa cat gag agg     1440
 Cys Gly Lys Ala Phe Ser Arg Cys Ser Ser Leu Val Gln His Glu Arg
 465                 470                 475                 480

 act cat act gga gag aaa cct ttt gaa tgt agc ata tgt ggg agg gct     1488
 Thr His Thr Gly Glu Lys Pro Phe Glu Cys Ser Ile Cys Gly Arg Ala
                 485                 490                 495

 ttt ggt cag agc cca tcc ctt tat aaa cat atg agg att cat aag aga     1536
 Phe Gly Gln Ser Pro Ser Leu Tyr Lys His Met Arg Ile His Lys Arg
             500                 505                 510

 ggc aaa cct tac caa agc agt aac tac agc ata gat ttc aag cac agc     1584
 Gly Lys Pro Tyr Gln Ser Ser Asn Tyr Ser Ile Asp Phe Lys His Ser
         515                 520                 525

 aca tct ctc act caa gat gaa agc act ctt acc gaa gtg aaa tcc tac     1632
 Thr Ser Leu Thr Gln Asp Glu Ser Thr Leu Thr Glu Val Lys Ser Tyr
     530                 535                 540

 cat tgt aat gac tgt ggg gaa gac ttt agt cac att aca gac ttt act     1680
 His Cys Asn Asp Cys Gly Glu Asp Phe Ser His Ile Thr Asp Phe Thr
 545                 550                 555                 560

 gac cat cag agg atc cat act gca gag aac ccc tat gat tgt gag cag     1728
 Asp His Gln Arg Ile His Thr Ala Glu Asn Pro Tyr Asp Cys Glu Gln
                 565                 570                 575

 gct ttt agt cag caa gct att tct cat cct gga gag aaa ccc tat caa     1776
 Ala Phe Ser Gln Gln Ala Ile Ser His Pro Gly Glu Lys Pro Tyr Gln
             580                 585                 590

 tgt aat gta tgt ggg aaa gct ttc aaa agg agt aca agt ttc ata gag     1824
 Cys Asn Val Cys Gly Lys Ala Phe Lys Arg Ser Thr Ser Phe Ile Glu
         595                 600                 605

 cat cac aga att cat act gga gag aaa ccc tat gaa tgt aat gag tgt     1872
 His His Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys
     610                 615                 620

 gga gaa gcc ttt agt cga cgc tca tcg ctt act caa cat gag aga acc     1920
 Gly Glu Ala Phe Ser Arg Arg Ser Ser Leu Thr Gln His Glu Arg Thr
 625                 630                 635                 640

 cac act gga gag aaa ccc tat gaa tgt att gac tgt ggg aaa gcc ttt     1968
 His Thr Gly Glu Lys Pro Tyr Glu Cys Ile Asp Cys Gly Lys Ala Phe
                 645                 650                 655

 agt caa agt tca tct ctc att cag cat gag aga act cat act gga gag     2016
 Ser Gln Ser Ser Ser Leu Ile Gln His Glu Arg Thr His Thr Gly Glu
             660                 665                 670

 aag ccc tat gaa tgt aat gaa tgt ggg aga gcc ttc cga aaa aaa acc     2064
 Lys Pro Tyr Glu Cys Asn Glu Cys Gly Arg Ala Phe Arg Lys Lys Thr
         675                 680                 685

 aac ctg cat gat cat cag aga att cat act gga gaa aaa ccc tat tct     2112
 Asn Leu His Asp His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Ser
     690                 695                 700

 tgt aag gaa tgt ggg aaa aac ttc agc cga agt tca gct ctt act aaa     2160
 Cys Lys Glu Cys Gly Lys Asn Phe Ser Arg Ser Ser Ala Leu Thr Lys
 705                 710                 715                 720

 cac cag aga att cat act cga aat aaa ctc tag                         2193
 His Gln Arg Ile His Thr Arg Asn Lys Leu 
                 725                 730





      <210> 162
      <211> 494
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (50)..(448)

      <400> 162
 cggagatccc ggggtcgcgc gagagccgca agcggagttg gtgggcgct    atg cta      55
                                                          Met Leu
                                                            1

 tca ccc gag gca gag cga gtg ctg cgg tac ctt gta gaa gtg gag gag      103
 Ser Pro Glu Ala Glu Arg Val Leu Arg Tyr Leu Val Glu Val Glu Glu
           5                  10                  15

 ctc gcc gag gag gtg ctg gcg gac aag cgg cag att gtg gac ctg gac      151
 Leu Ala Glu Glu Val Leu Ala Asp Lys Arg Gln Ile Val Asp Leu Asp
      20                  25                  30

 act aaa agg aat cag aat cga gag ggc ctg agg gcc ctg cag aag gat      199
 Thr Lys Arg Asn Gln Asn Arg Glu Gly Leu Arg Ala Leu Gln Lys Asp
  35                  40                  45                  50

 ctc agc ctc tct gaa gat gtg atg gtt tgc ttc ggg aac atg ttt atc      247
 Leu Ser Leu Ser Glu Asp Val Met Val Cys Phe Gly Asn Met Phe Ile
                  55                  60                  65

 aag atg cct cac cct gag aca aag gaa atg att gaa aaa gat caa gat      295
 Lys Met Pro His Pro Glu Thr Lys Glu Met Ile Glu Lys Asp Gln Asp
              70                  75                  80

 cat ctg gat aaa gaa ata gaa aaa ctg cgg aag caa ctt aaa gtg aag      343
 His Leu Asp Lys Glu Ile Glu Lys Leu Arg Lys Gln Leu Lys Val Lys
          85                  90                  95

 gtc aac cgc ctt ttt gag gcc caa ggc aaa ccg gag ctg aag ggt ttt      391
 Val Asn Arg Leu Phe Glu Ala Gln Gly Lys Pro Glu Leu Lys Gly Phe
     100                 105                 110

 aac ttg aac ccc ctc aac cag gat gag ctt aaa gct ctc aag gtc atc      439
 Asn Leu Asn Pro Leu Asn Gln Asp Glu Leu Lys Ala Leu Lys Val Ile
 115                 120                 125                 130

 ttg aaa gga tgagactcaa gaaccaagat gggggaccag caacccccca gggtca       494
 Leu Lys Gly 






      <210> 163
      <211> 2554
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (218)..(1129)

      <400> 163
 aaaataaaaa atccaaagtt gccataaatc atagtatgag ttctccatat atgttcacag     60

 agagaaagag attccctcac acctcttcta cagtggatgg aaaggtgcaa aaatctatca    120

 ccagcaacag aaggtgcaga ctgtgttggt ggcggtaatt ttgtccatca aatgaatatg    180

 tgtgaaaaca ttccctcctt tggccctaca ggtcaga atg gcg gca gcg gag cat     235
                                          Met Ala Ala Ala Glu His
                                            1               5

 cgt cat tct tca gga ttg ccc tac tgg ccc tac ctc aca gct gaa act      283
 Arg His Ser Ser Gly Leu Pro Tyr Trp Pro Tyr Leu Thr Ala Glu Thr
              10                  15                  20

 tta aaa aac agg atg ggc cac cag cca cct cct cca act caa caa cat      331
 Leu Lys Asn Arg Met Gly His Gln Pro Pro Pro Pro Thr Gln Gln His
          25                  30                  35

 tct ata act gat aac tcc ctg agc ctc aag aca cct ccc gag tgt ctg      379
 Ser Ile Thr Asp Asn Ser Leu Ser Leu Lys Thr Pro Pro Glu Cys Leu
      40                  45                  50

 ctc act ccc ctt cca ccc tca gct cta ccc tca gct cca ccc tca gcg      427
 Leu Thr Pro Leu Pro Pro Ser Ala Leu Pro Ser Ala Pro Pro Ser Ala
  55                  60                  65                  70

 gat gat aat ctc aag aca cgt gcc gag tgt ctg ctc cat ccc ctt cca      475
 Asp Asp Asn Leu Lys Thr Arg Ala Glu Cys Leu Leu His Pro Leu Pro
                  75                  80                  85

 ccc tca gcg gat gat aat ctc aag aca ctt tcc gag cgt cag ctc act      523
 Pro Ser Ala Asp Asp Asn Leu Lys Thr Leu Ser Glu Arg Gln Leu Thr
              90                  95                 100

 ccc ctt cca ccc tca gct cca ccc tca gca gat gat aat atc aag aca      571
 Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr
         105                 110                 115

 cct gcc gag cgt ctg cgg ggg ccg ctt cca ccc tca gca gat gat aat      619
 Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn
     120                 125                 130

 ctc aag aca cct tcc gag cgt cag ctc act ccc ctt cca ccc tca gct      667
 Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala
 135                 140                 145                 150

 cca ccc tca gca gat gat aat atc aag aca cct gcc gag cgt ctg cgg      715
 Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg
                 155                 160                 165

 ggg ccg ctt cca ccc tca gcg gat gat aat ctc aag aca cct tcc gag      763
 Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu
             170                 175                 180

 cgt cag ctc act ccc ctt cca ccc tca gct cca ccc tca gca gat gat      811
 Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp
         185                 190                 195

 aat atc aag aca cct gcc gag cgt ctg cgg ggg ccg ctt cca ccc tca      859
 Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser
     200                 205                 210

 gcg gat gat aat ctc aag aca cct tcc gag cgt cag ctc act ccc ctt      907
 Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr Pro Leu
 215                 220                 225                 230

 cca ccc tca gct cca ccc tca gca gat gat aat atc aag aca cct gcc      955
 Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala
                 235                 240                 245

 gag cgt ctg cgg ggg ccg ctt cca ccc tca gcg gat gat aat ctc aag     1003
 Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys
             250                 255                 260

 aca cct tcc gag cgt cag ctc act ccc ttt cca ccc tca gct cca ccc     1051
 Thr Pro Ser Glu Arg Gln Leu Thr Pro Phe Pro Pro Ser Ala Pro Pro
         265                 270                 275

 tca gca gat gat aat atc aag aca cct gcc gag cgt ctg cgg gga gcg     1099
 Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg Gly Ala
     280                 285                 290

 tct gcg ggg gcc gct tcc acc ctc agc gga t gataatctca agacaccttc     1150
 Ser Ala Gly Ala Ala Ser Thr Leu Ser Gly 
 295                 300

 cgagcgtcag ctcactcccc ttccaccctc agctccaccc tcagcagatg ataatatcaa   1210

 gacacctgcc gagcgtctgc gggggccgct tccaccctca gcggatgata atctcaagac   1270

 accttccgag cgtcagctca ctccccttcc accctcagct ccaccctcag cagatgataa   1330

 tatcaagaca cctgccgagc gtctgcgggg gccgcttcca ccctcagcgg atgataatct   1390

 caagacacct tccgagcgtc agctcactcc ccttccaccc tcagctccac cctcagcaga   1450

 tgataatatc aagacacctg ccgagcgtct gcgggggccg cttccaccct cagcagatga   1510

 taatctcaag acaccttccg agcgtcagct cactcccctt ccaccctcag ctccaccctc   1570

 agcagatgat aatatcaaga cacctgccga gcgtctgcgg gggccgcttc caccctcagc   1630

 ggatgataat ctcaagacac cttccgagcg tcagctcact ccctttccac cctcagctcc   1690

 accctcagca gatgataata tcaagacacc tgccgagcgt ctgcggggag cgtctgcggg   1750

 ggccgcttcc accctcagcg gatgataatc tcaagacacc ttccgagcgt cagctcactc   1810

 cccttccacc ctcagctcca ccctcagcag atgataatat caagacacct gccgagcgtc   1870

 tgcgggggcc gcttccaccc tcagcggatg ataatctcaa gacaccttcc gagcgtcagc   1930

 tcactcccct tccaccctca gctccaccct cagcagatga taatatcaag acacctgccg   1990

 agcgtctgcg gggggccgct tccaccctca gccgatgata atctcaagac acctccctta   2050

 gctactcagg aggctgaggc agaaaaacca cgcaaaccca agaggcagag ggcggctgag   2110

 atggaaccac ctcccgaacc caagaggcag agggtcggtg acgtggaacc gtcacgcaaa   2170

 cccaagaggc ggaggaccgc tgacgtggaa ccatcatcac ccgaacccaa gaggcggagg   2230

 gtcggtgatg tggaaccgtc acgcaaaccc aagaggcgga gggccgctga cgtggaacca   2290

 tcatcacccg aacccaagag gcggagggtc ggtgacgtgg aaccgtcacg caaacccaag   2350

 aggcggaggg ccgctgacgt ggaaccatca ttacccgaac ccaagaggcg gaggttgagc   2410

 tgagaagagg ccagtgcact caagcctgag caataagaat aaaaccgagt agaacaaaat   2470

 aaaaaattca aaaaacaaaa caaaacccac actccaaaaa ctaacaaaga ataaataaat   2530

 aatataaaaa taaaaaaaaa aaaa                                          2554




      <210> 164
      <211> 2542
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (218)..(1117)

      <400> 164
 aaaataaaaa atccaaagtt gccataaatc atagtatgag ttctccatat atgttcacag     60

 agagaaagag attccctcac acctcttcta cagtggatgg aaaggtgcaa aaatctatca    120

 ccagcaacag aaggtgcaga ctgtgttggt ggcggtaatt ttgtccatca aatgaatatg    180

 tgtgaaaaca ttccctcctt tggccctaca ggtcaga atg gcg gca gcg gag cat     235
                                          Met Ala Ala Ala Glu His
                                            1               5

 cgt cat tct tca gga ttg ccc tac tgg ccc tac ctc aca gct gaa act      283
 Arg His Ser Ser Gly Leu Pro Tyr Trp Pro Tyr Leu Thr Ala Glu Thr
              10                  15                  20

 tta aaa aac agg atg ggc cac cag cca cct cct cca act caa caa cat      331
 Leu Lys Asn Arg Met Gly His Gln Pro Pro Pro Pro Thr Gln Gln His
          25                  30                  35

 tct ata act gat aac tcc ctg agc ctc aag aca cct ccc gag tgt ctg      379
 Ser Ile Thr Asp Asn Ser Leu Ser Leu Lys Thr Pro Pro Glu Cys Leu
      40                  45                  50

 ctc act ccc ctt cca ccc tca gct cca ccc tca gcg gat gat aat ctc      427
 Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Leu
  55                  60                  65                  70

 aag aca cgt gcc gag tgt ctg ctc cat ccc ctt cca ccc tca gcg gat      475
 Lys Thr Arg Ala Glu Cys Leu Leu His Pro Leu Pro Pro Ser Ala Asp
                  75                  80                  85

 gat aat ctc aag aca ctt tcc gag cgt cag ctc act ccc ctt cca ccc      523
 Asp Asn Leu Lys Thr Leu Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro
              90                  95                 100

 tca gct cca ccc tca gca gat gat aat atc aag aca cct gcc gag cgt      571
 Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg
         105                 110                 115

 ctg cgg ggg ccg ctt cca ccc tca gca gat gat aat ctc aag aca cct      619
 Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro
     120                 125                 130

 tcc gag cgt cag ctc act ccc ctt cca ccc tca gct cca ccc tca gca      667
 Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala
 135                 140                 145                 150

 gat gat aat atc aag aca cct gcc gag cgt ctg cgg ggg ccg ctt cca      715
 Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro
                 155                 160                 165

 ccc tca gcg gat gat aat ctc aag aca cct tcc gag cgt cag ctc act      763
 Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr
             170                 175                 180

 ccc ctt cca ccc tca gct cca ccc tca gca gat gat aat atc aag aca      811
 Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr
         185                 190                 195

 cct gcc gag cgt ctg cgg ggg ccg ctt cca ccc tca gcg gat gat aat      859
 Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn
     200                 205                 210

 ctc aag aca cct tcc gag cgt cag ctc act ccc ctt cca ccc tca gct      907
 Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala
 215                 220                 225                 230

 cca ccc tca gca gat gat aat atc aag aca cct gcc gag cgt ctg cgg      955
 Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg
                 235                 240                 245

 ggg ccg ctt cca ccc tca gcg gat gat aat ctc aag aca cct tcc gag     1003
 Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu
             250                 255                 260

 cgt cag ctc act ccc ttt cca ccc tca gct cca ccc tca gca gat gat     1051
 Arg Gln Leu Thr Pro Phe Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp
         265                 270                 275

 aat atc aag aca cct gcc gag cgt ctg cgg gga gcg tct gcg ggg gcc     1099
 Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg Gly Ala Ser Ala Gly Ala
     280                 285                 290

 gct tcc acc ctc agc gga tgataa tctcaagaca ccttccgagc gtcagctcac     1153
 Ala Ser Thr Leu Ser Gly 
 295                 300

 tccccttcca ccctcagctc caccctcagc agatgataat atcaagacac ctgccgagcg   1213

 tctgcggggg ccgcttccac cctcagcgga tgataatctc aagacacctt ccgagcgtca   1273

 gctcactccc cttccaccct cagctccacc ctcagcagat gataatatca agacacctgc   1333

 cgagcgtctg cgggggccgc ttccaccctc agcggatgat aatctcaaga caccttccga   1393

 gcgtcagctc actccccttc caccctcagc tccaccctca gcagatgata atatcaagac   1453

 acctgccgag cgtctgcggg ggccgcttcc accctcagca gatgataatc tcaagacacc   1513

 ttccgagcgt cagctcactc cccttccacc ctcagctcca ccctcagcag atgataatat   1573

 caagacacct gccgagcgtc tgcgggggcc gcttccaccc tcagcggatg ataatctcaa   1633

 gacaccttcc gagcgtcagc tcactccctt tccaccctca gctccaccct cagcagatga   1693

 taatatcaag acacctgccg agcgtctgcg gggagcgtct gcgggggccg cttccaccct   1753

 cagcggatga taatctcaag acaccttccg agcgtcagct cactcccctt ccaccctcag   1813

 ctccaccctc agcagatgat aatatcaaga cacctgccga gcgtctgcgg gggccgcttc   1873

 caccctcagc ggatgataat ctcaagacac cttccgagcg tcagctcact ccccttccac   1933

 cctcagctcc accctcagca gatgataata tcaagacacc tgccgagcgt ctgcgggggg   1993

 ccgcttccac cctcagccga tgataatctc aagacacctc ccttagctac tcaggaggct   2053

 gaggcagaaa aaccacgcaa acccaagagg cagagggcgg ctgagatgga accacctccc   2113

 gaacccaaga ggcagagggt cggtgacgtg gaaccgtcac gcaaacccaa gaggcggagg   2173

 accgctgacg tggaaccatc atcacccgaa cccaagaggc ggagggtcgg tgatgtggaa   2233

 ccgtcacgca aacccaagag gcggagggcc gctgacgtgg aaccatcatc acccgaaccc   2293

 aagaggcgga gggtcggtga cgtggaaccg tcacgcaaac ccaagaggcg gagggccgct   2353

 gacgtggaac catcattacc cgaacccaag aggcggaggt tgagctgaga agaggccagt   2413

 gcactcaagc ctgagcaata agaataaaac cgagtagaac aaaataaaaa attcaaaaaa   2473

 caaaacaaaa cccacactcc aaaaactaac aaagaataaa taaataatat aaaaataaaa   2533

 aaaaaaaaa                                                           2542




      <210> 165
      <211> 2532
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (218)..(1753)

      <400> 165
 aaaataaaaa atccaaagtt gccataaatc atagtatgag ttctccatat atgttcacag     60

 agagaaagag attccctcac acctcttcta cagtggatgg aaaggtgcaa aaatctatca    120

 ccagcaacag aaggtgcaga ctgtgttggt ggcggtaatt ttgtccatca aatgaatatg    180

 tgtgaaaaca ttccctcctt tggccctaca ggtcaga atg gcg gca gcg gag cat     235
                                          Met Ala Ala Ala Glu His
                                            1               5

 cgt cat tct tca gga ttg ccc tac tgg ccc tac ctc aca gct gaa act      283
 Arg His Ser Ser Gly Leu Pro Tyr Trp Pro Tyr Leu Thr Ala Glu Thr
              10                  15                  20

 tta aaa aac agg atg ggc cac cag cca cct cct cca act caa caa cat      331
 Leu Lys Asn Arg Met Gly His Gln Pro Pro Pro Pro Thr Gln Gln His
          25                  30                  35

 tct ata act gat aac tcc ctg agc ctc aag aca cct ccc gag tgt ctg      379
 Ser Ile Thr Asp Asn Ser Leu Ser Leu Lys Thr Pro Pro Glu Cys Leu
      40                  45                  50

 ctc act ccc ctt cca ccc tca gct cta ccc tca gct cca ccc tca gcg      427
 Leu Thr Pro Leu Pro Pro Ser Ala Leu Pro Ser Ala Pro Pro Ser Ala
  55                  60                  65                  70

 gat gat aat ctc aag aca cgt gcc gag tgt ctg ctc cat ccc ctt cca      475
 Asp Asp Asn Leu Lys Thr Arg Ala Glu Cys Leu Leu His Pro Leu Pro
                  75                  80                  85

 ccc tca gcg gat gat aat ctc aag aca ctt tcc gag cgt cag ctc act      523
 Pro Ser Ala Asp Asp Asn Leu Lys Thr Leu Ser Glu Arg Gln Leu Thr
              90                  95                 100

 ccc ctt cca ccc tca gct cca ccc tca gca gat gat aat atc aag aca      571
 Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr
         105                 110                 115

 cct gcc ttc cac cct cag cag atg ata atc tca aga cac ctt ccg agc      619
 Pro Ala Phe His Pro Gln Gln Met Ile Ile Ser Arg His Leu Pro Ser
     120                 125                 130

 gtc agc tca ctc ccc ttc cac cct cag ctc cac cct cag cag atg ata      667
 Val Ser Ser Leu Pro Phe His Pro Gln Leu His Pro Gln Gln Met Ile
 135                 140                 145                 150

 ata tca aga cac ctg ccg agc gtc tgc ggg ggc cgc ttc cac cct cag      715
 Ile Ser Arg His Leu Pro Ser Val Cys Gly Gly Arg Phe His Pro Gln
                 155                 160                 165

 cgg atg ata atc tca aga cac ctt ccg agc gtc agc tca ctc ccc ttc      763
 Arg Met Ile Ile Ser Arg His Leu Pro Ser Val Ser Ser Leu Pro Phe
             170                 175                 180

 cac cct cag ctc cac cct cag cag atg ata ata tca aga cac ctg ccg      811
 His Pro Gln Leu His Pro Gln Gln Met Ile Ile Ser Arg His Leu Pro
         185                 190                 195

 agc gtc tgc ggg ggc cgc ttc cac cct cag cgg atg ata atc tca aga      859
 Ser Val Cys Gly Gly Arg Phe His Pro Gln Arg Met Ile Ile Ser Arg
     200                 205                 210

 cac ctt ccg agc gtc agc tca ctc ccc ttc cac cct cag ctc cac cct      907
 His Leu Pro Ser Val Ser Ser Leu Pro Phe His Pro Gln Leu His Pro
 215                 220                 225                 230

 cag cag atg ata ata tca aga cac ctg ccg agc gtc tgc ggg ggc cgc      955
 Gln Gln Met Ile Ile Ser Arg His Leu Pro Ser Val Cys Gly Gly Arg
                 235                 240                 245

 ttc cac cct cag cgg atg ata atc tca aga cac ctt ccg agc gtc agc     1003
 Phe His Pro Gln Arg Met Ile Ile Ser Arg His Leu Pro Ser Val Ser
             250                 255                 260

 tca ctc cct ttc cac cct cag ctc cac cct cag cag atg ata ata tca     1051
 Ser Leu Pro Phe His Pro Gln Leu His Pro Gln Gln Met Ile Ile Ser
         265                 270                 275

 aga cac ctg ccg agc gtc tgc ggg gag cgt ctg cgg ggg ccg ctt cca     1099
 Arg His Leu Pro Ser Val Cys Gly Glu Arg Leu Arg Gly Pro Leu Pro
     280                 285                 290

 ccc tca gcg gat gat aat ctc aag aca cct tcc gag cgt cag ctc act     1147
 Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr
 295                 300                 305                 310

 ccc ctt cca ccc tca gct cca ccc tca gca gat gat aat atc aag aca     1195
 Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr
                 315                 320                 325

 cct gcc gag cgt ctg cgg ggg ccg ctt cca ccc tca gcg gat gat aat     1243
 Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn
             330                 335                 340

 ctc aag aca cct tcc gag cgt cag ctc act ccc ctt cca ccc tca gct     1291
 Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala
         345                 350                 355

 cca ccc tca gca gat gat aat atc aag aca cct gcc gag cgt ctg cgg     1339
 Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg
     360                 365                 370

 ggg ccg ctt cca ccc tca gcg gat gat aat ctc aag aca cct tcc gag     1387
 Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu
 375                 380                 385                 390

 cgt cag ctc act ccc ctt cca ccc tca gct cca ccc tca gca gat gat     1435
 Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp
                 395                 400                 405

 aat atc aag aca cct gcc gag cgt ctg cgg ggg ccg ctt cca ccc tca     1483
 Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser
             410                 415                 420

 gca gat gat aat ctc aag aca cct tcc gag cgt cag ctc act ccc ctt     1531
 Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr Pro Leu
         425                 430                 435

 cca ccc tca gct cca ccc tca gca gat gat aat atc aag aca cct gcc     1579
 Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala
     440                 445                 450

 gag cgt ctg cgg ggg ccg ctt cca ccc tca gcg gat gat aat ctc aag     1627
 Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys
 455                 460                 465                 470

 aca cct tcc gag cgt cag ctc act ccc ttt cca ccc tca gct cca ccc     1675
 Thr Pro Ser Glu Arg Gln Leu Thr Pro Phe Pro Pro Ser Ala Pro Pro
                 475                 480                 485

 tca gca gat gat aat atc aag aca cct gcc gag cgt ctg cgg gga gcg     1723
 Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg Gly Ala
             490                 495                 500

 tct gcg ggg gcc gct tcc acc ctc agc gga t gataatctca agacaccttc     1774
 Ser Ala Gly Ala Ala Ser Thr Leu Ser Gly 
         505                 510

 cgagcgtcag ctcactcccc ttccaccctc agctccaccc tcagcagatg ataatatcaa   1834

 gacacctgcc gagcgtctgc gggggccgct tccaccctca gcggatgata atctcaagac   1894

 accttccgag cgtcagctca ctccccttcc accctcagct ccaccctcag cagatgataa   1954

 tatcaagaca cctgccgagc gtctgcgggg ggccgcttcc accctcagcc gatgataatc   2014

 tcaagacacc tcccttagct actcaggagg ctgaggcaga aaaaccacgc aaacccaaga   2074

 ggcagagggc ggctgagatg gaaccacctc ccgaacccaa gaggcagagg gtcggtgacg   2134

 tggaaccgtc acgcaaaccc aagaggcgga ggaccgctga cgtggaacca tcatcacccg   2194

 aacccaagag gcggagggtc ggtgatgtgg aaccgtcacg caaacccaag aggcggaggg   2254

 ccgctgacgt ggaaccatca tcacccgaac ccaagaggcg gagggtcggt gacgtggaac   2314

 cgtcacgcaa acccaagagg cggagggccg ctgacgtgga accatcatta cccgaaccca   2374

 agaggcggag gttgagctga gaagaggcca gtgcactcaa gcctgagcaa taagaataaa   2434

 accgagtaga acaaaataaa aaattcaaaa aacaaaacaa aacccacact ccaaaaacta   2494

 acaaagaata aataaataat ataaaaataa aaaaaaaa                           2532




      <210> 166
      <211> 2541
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (218)..(1759)

      <400> 166
 aaaataaaaa atccaaagtt gccataaatc atagtatgag ttctccatat atgttcacag     60

 agagaaagag attccctcac acctcttcta cagtggatgg aaaggtgcaa aaatctatca    120

 ccagcaacag aaggtgcaga ctgtgttggt ggcggtaatt ttgtccatca aatgaatatg    180

 tgtgaaaaca ttccctcctt tggccctaca ggtcaga atg gcg gca gcg gag cat     235
                                          Met Ala Ala Ala Glu His
                                            1               5

 cgt cat tct tca gga ttg ccc tac tgg ccc tac ctc aca gct gaa act      283
 Arg His Ser Ser Gly Leu Pro Tyr Trp Pro Tyr Leu Thr Ala Glu Thr
              10                  15                  20

 tta aaa aac agg atg ggc cac cag cca cct cct cca act caa caa cat      331
 Leu Lys Asn Arg Met Gly His Gln Pro Pro Pro Pro Thr Gln Gln His
          25                  30                  35

 tct ata act gat aac tcc ctg agc ctc aag aca cct ccc gag tgt ctg      379
 Ser Ile Thr Asp Asn Ser Leu Ser Leu Lys Thr Pro Pro Glu Cys Leu
      40                  45                  50

 ctc act ccc ctt cca ccc tca gct cta ccc tca gct cca ccc tca gcg      427
 Leu Thr Pro Leu Pro Pro Ser Ala Leu Pro Ser Ala Pro Pro Ser Ala
  55                  60                  65                  70

 gat gat aat ctc aag aca cgt gcc gag tgt ctg ctc cat ccc ctt cca      475
 Asp Asp Asn Leu Lys Thr Arg Ala Glu Cys Leu Leu His Pro Leu Pro
                  75                  80                  85

 ccc tca gcg gat gat aat ctc aag aca ctt tcc gag cgt cag ctc act      523
 Pro Ser Ala Asp Asp Asn Leu Lys Thr Leu Ser Glu Arg Gln Leu Thr
              90                  95                 100

 ccc ctt cca ccc tca gct cca ccc tca gca gat gat aat atc aag aca      571
 Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr
         105                 110                 115

 cct gcc gag cgt ctg cgg ggg ccg ctt cca ccc tca gca gat gat aat      619
 Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn
     120                 125                 130

 ctc aag aca cct tcc gag cgt cag ctc act ccc ctt cca ccc tca gct      667
 Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala
 135                 140                 145                 150

 cca ccc tca gca gat gat aat atc aag aca cct gcc gag cgt ctg cgg      715
 Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg
                 155                 160                 165

 ggg ccg ctt cca ccc tca gcg gat gat aat ctc aag aca cct tcc gag      763
 Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu
             170                 175                 180

 cgt cag ctc act ccc ctt cca ccc tca gct cca ccc tca gca gat gat      811
 Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp
         185                 190                 195

 aat atc aag aca cct gcc gag cgt ctg cgg ggg ccg ctt cca ccc tca      859
 Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser
     200                 205                 210

 gcg gat gat aat ctc aag aca cct tcc gag cgt cag ctc act ccc ctt      907
 Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr Pro Leu
 215                 220                 225                 230

 cca ccc tca gct cca ccc tca gca gat gat aat atc aag aca cct gcc      955
 Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala
                 235                 240                 245

 gag cgt ctg cgg ggg ccg ctt cca ccc tca gcg gat gat aat ctc aag     1003
 Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys
             250                 255                 260

 aca cct tcc gag cgt cag ctc act ccc ttt cca ccc tca gct cca ccc     1051
 Thr Pro Ser Glu Arg Gln Leu Thr Pro Phe Pro Pro Ser Ala Pro Pro
         265                 270                 275

 tca gca gat gat aat atc aag aca cct gcc gag cgt ctg cgg ggg ccg     1099
 Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg Gly Pro
     280                 285                 290

 ctt cca ccc tca gcg gat gat aat ctc aag aca cct tcc gag cgt cag     1147
 Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln
 295                 300                 305                 310

 ctc act ccc ctt cca ccc tca gct cca ccc tca gca gat gat aat atc     1195
 Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile
                 315                 320                 325

 aag aca cct gcc gag cgt ctg cgg ggg ccg ctt cca ccc tca gcg gat     1243
 Lys Thr Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp
             330                 335                 340

 gat aat ctc aag aca cct tcc gag cgt cag ctc act ccc ctt cca ccc     1291
 Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro
         345                 350                 355

 tca gct cca ccc tca gca gat gat aat atc aag aca cct gcc gag cgt     1339
 Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg
     360                 365                 370

 ctg cgg ggg ccg ctt cca ccc tca gcg gat gat aat ctc aag aca cct     1387
 Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro
 375                 380                 385                 390

 tcc gag cgt cag ctc act ccc ctt cca ccc tca gct cca ccc tca gca     1435
 Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala
                 395                 400                 405

 gat gat aat atc aag aca cct gcc gag cgt ctg cgg ggg ccg ctt cca     1483
 Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro
             410                 415                 420

 ccc tca gca gat gat aat ctc aag aca cct tcc gag cgt cag ctc act     1531
 Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr
         425                 430                 435

 ccc ctt cca ccc tca gct cca ccc tca gca gat gat aat atc aag aca     1579
 Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr
     440                 445                 450

 cct gcc gag cgt ctg cgg ggg ccg ctt cca ccc tca gcg gat gat aat     1627
 Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn
 455                 460                 465                 470

 ctc aag aca cct tcc gag cgt cag ctc act ccc ttt cca ccc tca gct     1675
 Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr Pro Phe Pro Pro Ser Ala
                 475                 480                 485

 cca ccc tca gca gat gat aat atc aag aca cct gcc gag cgt ctg cgg     1723
 Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg
             490                 495                 500

 gga gcg tct gcg ggg gcc gct tcc acc ctc agc gga tgat aatctcaaga     1773
 Gly Ala Ser Ala Gly Ala Ala Ser Thr Leu Ser Gly 
         505                 510

 caccttccga gcgtcagctc actccccttc caccctcagc tccaccctca gcagatgata   1833

 atatcaagac acctgccgag cgtctgcggg ggccgcttcc accctcagcg gatgataatc   1893

 tcaagacacc ttccgagcgt cagctcactc cccttccacc ctcagctcca ccctcagcag   1953

 atgataatat caagacacct gccgagcgtc tgcggggggc cgcttccacc ctcagccgat   2013

 gataatctca agacacctcc cttagctact caggaggctg aggcagaaaa accacgcaaa   2073

 cccaagaggc agagggcggc tgagatggaa ccacctcccg aacccaagag gcagagggtc   2133

 ggtgacgtgg aaccgtcacg caaacccaag aggcggagga ccgctgacgt ggaaccatca   2193

 tcacccgaac ccaagaggcg gagggtcggt gatgtggaac cgtcacgcaa acccaagagg   2253

 cggagggccg ctgacgtgga accatcatca cccgaaccca agaggcggag ggtcggtgac   2313

 gtggaaccgt cacgcaaacc caagaggcgg agggccgctg acgtggaacc atcattaccc   2373

 gaacccaaga ggcggaggtt gagctgagaa gaggccagtg cactcaagcc tgagcaataa   2433

 gaataaaacc gagtagaaca aaataaaaaa ttcaaaaaac aaaacaaaac ccacactcca   2493

 aaaactaaca aagaataaat aaataatata aaaataaaaa aaaaaaaa                2541




      <210> 167
      <211> 1156
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (134)..(769)

      <400> 167
 agctaactac cgcgccgggg ccgggtccgg ggccggggcc cgacgtcccc gcggggcccg     60

 ggaccgcgag gaggacggcg ggggcctgga gcccgcggcc gtggcccgcg acctattgag    120

 gggcacatct aac   atg tca ttt gag gag ctg ttg gaa ttg cag agc caa     169
                  Met Ser Phe Glu Glu Leu Leu Glu Leu Gln Ser Gln
                    1               5                  10

 gtg ggg act aag acg tac aaa caa ttg gta gct gga aat agt cct aag      217
 Val Gly Thr Lys Thr Tyr Lys Gln Leu Val Ala Gly Asn Ser Pro Lys
          15                  20                  25

 aaa caa gct tct aga cca cct atc caa aat gca tgt gtt gca gat aag      265
 Lys Gln Ala Ser Arg Pro Pro Ile Gln Asn Ala Cys Val Ala Asp Lys
      30                  35                  40

 cac agg cct ctg gaa atg tca gcc aag atc cga gta cca ttt tta cgt      313
 His Arg Pro Leu Glu Met Ser Ala Lys Ile Arg Val Pro Phe Leu Arg
  45                  50                  55                  60

 cag gtt gtt ccc att agt aaa aag gta gcc cgg gac cct cgc ttt gat      361
 Gln Val Val Pro Ile Ser Lys Lys Val Ala Arg Asp Pro Arg Phe Asp
                  65                  70                  75

 gat ctg tca ggg gaa tat aat cct gag gtg ttt gac aaa aca tac caa      409
 Asp Leu Ser Gly Glu Tyr Asn Pro Glu Val Phe Asp Lys Thr Tyr Gln
              80                  85                  90

 ttc ttg aat gac atc cga gcg aaa gag aaa gag ctt gtg aaa aaa cag      457
 Phe Leu Asn Asp Ile Arg Ala Lys Glu Lys Glu Leu Val Lys Lys Gln
          95                 100                 105

 ttg aag aag cac ctt tca gga gag gag cat gag aaa ctg cag caa ctg      505
 Leu Lys Lys His Leu Ser Gly Glu Glu His Glu Lys Leu Gln Gln Leu
     110                 115                 120

 ctt cag cga atg gag cag caa gaa atg gca cag cag gaa cga aag caa      553
 Leu Gln Arg Met Glu Gln Gln Glu Met Ala Gln Gln Glu Arg Lys Gln
 125                 130                 135                 140

 cag cag gag ctg cac ctg gcc ctg aag caa gaa cgt cgg gct cag gcc      601
 Gln Gln Glu Leu His Leu Ala Leu Lys Gln Glu Arg Arg Ala Gln Ala
                 145                 150                 155

 cag cag ggc cat cgg cca tac ttc ctg aaa aaa tct gag cag cgc cag      649
 Gln Gln Gly His Arg Pro Tyr Phe Leu Lys Lys Ser Glu Gln Arg Gln
             160                 165                 170

 ttg gca cta gct gag aag ttc aag gag ctg aaa cgc agc aag aaa ttg      697
 Leu Ala Leu Ala Glu Lys Phe Lys Glu Leu Lys Arg Ser Lys Lys Leu
         175                 180                 185

 gag aac ttc ttg agt cga aag agg cga cga aat gca ggc aag gac agg      745
 Glu Asn Phe Leu Ser Arg Lys Arg Arg Arg Asn Ala Gly Lys Asp Arg
     190                 195                 200

 aga cat ctc cct ttg agc aaa gag taataaggaa ctatcctctg ctctgccact     799
 Arg His Leu Pro Leu Ser Lys Glu 
 205                 210

 gccccaggga gacatggatc tgtgaggaca gatttggcca cggctggttt ccgttcaagg    859

 gcaaggatca cagctgccct tgaatctcat tgcctcagag aagactagag ggctcttgga    919

 ctatccctag ggctacacaa gaatagttca gccttctgcc atgccacaca gcctcagctt    979

 gaatctggtt cattgcgtcc tcgtgttctt ctctcatcct tgccttaaac cagggattct   1039

 gataccgaag aagaggggcc aatgaaaacc atggagtctg ttcgtgactc ccagggctgg   1099

 gacattatgt aggagccact tcataaacat tctctttact catcaaaaaa aaaaaaa      1156




      <210> 168
      <211> 2306
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (223)..(1944)

      <400> 168
 tcattaataa gacaaactac tggtgaaaaa aagaaccctt tccgatattt tagtaaacaa     60

 gaattaagag agctctttac aatcgaggat cttcagaact ctgtaaccca gctgcagctt    120

 cagtctttgc atgctgctca gaggaaatct gatataaaac tagatgaaca tattgcctac    180

 ctgcagtctt tggggatagc tggaatctca gaccatgatt tg   atg tac aca tgt     234
                                                  Met Tyr Thr Cys
                                                    1

 gat ctg tct gtt aaa gaa gag ctt gat gtg gta gaa gaa tct cac tat      282
 Asp Leu Ser Val Lys Glu Glu Leu Asp Val Val Glu Glu Ser His Tyr
   5                  10                  15                  20

 att caa caa agg gtt cag aaa gct caa ttc ctc gtt gaa ttc gag tct      330
 Ile Gln Gln Arg Val Gln Lys Ala Gln Phe Leu Val Glu Phe Glu Ser
                  25                  30                  35

 caa aat aaa gag ttc ctg atg gaa caa caa aga act aga aat gag ggg      378
 Gln Asn Lys Glu Phe Leu Met Glu Gln Gln Arg Thr Arg Asn Glu Gly
              40                  45                  50

 gcc tgg cta aga gaa cct gta ttt cct tct tca aca aag aag aaa tgc      426
 Ala Trp Leu Arg Glu Pro Val Phe Pro Ser Ser Thr Lys Lys Lys Cys
          55                  60                  65

 cct aaa ttg aat aaa cca cag cct cag cct tca cct ctt cta agt act      474
 Pro Lys Leu Asn Lys Pro Gln Pro Gln Pro Ser Pro Leu Leu Ser Thr
      70                  75                  80

 cat cat act cag gaa gaa gat atc agt tcc aaa atg gca agt gta gtc      522
 His His Thr Gln Glu Glu Asp Ile Ser Ser Lys Met Ala Ser Val Val
  85                  90                  95                 100

 att gat gat ctg ccc aaa gag ggt gag aaa caa gat ctc tcc agt ata      570
 Ile Asp Asp Leu Pro Lys Glu Gly Glu Lys Gln Asp Leu Ser Ser Ile
                 105                 110                 115

 aag gtg aat gtt acc acc ttg caa gat ggt aaa ggt aca ggt agt gct      618
 Lys Val Asn Val Thr Thr Leu Gln Asp Gly Lys Gly Thr Gly Ser Ala
             120                 125                 130

 gac tct ata gct act tta cca aag ggg ttt gga agt gta gaa gaa ctt      666
 Asp Ser Ile Ala Thr Leu Pro Lys Gly Phe Gly Ser Val Glu Glu Leu
         135                 140                 145

 tgt act aac tct tca ttg gga atg gaa aaa agc ttt gca act aaa aat      714
 Cys Thr Asn Ser Ser Leu Gly Met Glu Lys Ser Phe Ala Thr Lys Asn
     150                 155                 160

 gaa gct gta caa aaa gag aca tta caa gag ggg cct aag caa gag gca      762
 Glu Ala Val Gln Lys Glu Thr Leu Gln Glu Gly Pro Lys Gln Glu Ala
 165                 170                 175                 180

 ctg caa gag gat cct ctg gaa agt ttt aat tat gta ctt agc aaa tca      810
 Leu Gln Glu Asp Pro Leu Glu Ser Phe Asn Tyr Val Leu Ser Lys Ser
                 185                 190                 195

 acc aaa gct gat att ggg cca aat tta gat caa cta aag gat gat gag      858
 Thr Lys Ala Asp Ile Gly Pro Asn Leu Asp Gln Leu Lys Asp Asp Glu
             200                 205                 210

 att tta cgt cat tgc aat cct tgg ccc att att tcc ata aca aat gaa      906
 Ile Leu Arg His Cys Asn Pro Trp Pro Ile Ile Ser Ile Thr Asn Glu
         215                 220                 225

 agt caa aat gca gaa tca aat gta tcc att att gaa ata gct gat gac      954
 Ser Gln Asn Ala Glu Ser Asn Val Ser Ile Ile Glu Ile Ala Asp Asp
     230                 235                 240

 ctt tca gca tcc cat agt gca ctg cag gat gct caa gca agt gag gcc     1002
 Leu Ser Ala Ser His Ser Ala Leu Gln Asp Ala Gln Ala Ser Glu Ala
 245                 250                 255                 260

 aag ttg gaa gag gaa cct tca gca tct tca cca cag tat gca tgt gat     1050
 Lys Leu Glu Glu Glu Pro Ser Ala Ser Ser Pro Gln Tyr Ala Cys Asp
                 265                 270                 275

 ttc aat ctt ttc ttg gaa gac tca gca gac aac aga caa aat ttt tcc     1098
 Phe Asn Leu Phe Leu Glu Asp Ser Ala Asp Asn Arg Gln Asn Phe Ser
             280                 285                 290

 agt cag tct tta gag cat gtt gag aaa gaa aat agc ttg tgt ggc tct     1146
 Ser Gln Ser Leu Glu His Val Glu Lys Glu Asn Ser Leu Cys Gly Ser
         295                 300                 305

 gca cct aat tcc aga gca ggg ttt gtg cat agc aaa aca tgt ctc agt     1194
 Ala Pro Asn Ser Arg Ala Gly Phe Val His Ser Lys Thr Cys Leu Ser
     310                 315                 320

 tgg gag ttt tct gag aaa gac gat gaa cca gaa gaa gta gta gtt aaa     1242
 Trp Glu Phe Ser Glu Lys Asp Asp Glu Pro Glu Glu Val Val Val Lys
 325                 330                 335                 340

 gca aaa atc aga agt aaa gct aga agg att gtt tca gat ggc gaa gat     1290
 Ala Lys Ile Arg Ser Lys Ala Arg Arg Ile Val Ser Asp Gly Glu Asp
                 345                 350                 355

 gaa gat gat tct ttt aaa gat acc tca agc ata aat cca ttc aac aca     1338
 Glu Asp Asp Ser Phe Lys Asp Thr Ser Ser Ile Asn Pro Phe Asn Thr
             360                 365                 370

 tct ctc ttt caa ttc tca tct gtg aaa caa ttt gat gct tca act ccc     1386
 Ser Leu Phe Gln Phe Ser Ser Val Lys Gln Phe Asp Ala Ser Thr Pro
         375                 380                 385

 aaa aat gac atc agt cca cca gga agg ttc ttt tca tct caa ata ccc     1434
 Lys Asn Asp Ile Ser Pro Pro Gly Arg Phe Phe Ser Ser Gln Ile Pro
     390                 395                 400

 agt agt gta aat aag tct atg aac tct aga aga tct ctg gct tct agg     1482
 Ser Ser Val Asn Lys Ser Met Asn Ser Arg Arg Ser Leu Ala Ser Arg
 405                 410                 415                 420

 agg tct ctt att aat atg gtt tta gac cac gtg gag gac atg gag gaa     1530
 Arg Ser Leu Ile Asn Met Val Leu Asp His Val Glu Asp Met Glu Glu
                 425                 430                 435

 aga ctt gac gac agc agt gaa gca aag ggt cct gaa gat tat cca gaa     1578
 Arg Leu Asp Asp Ser Ser Glu Ala Lys Gly Pro Glu Asp Tyr Pro Glu
             440                 445                 450

 gaa ggg gtg gag gaa agc agt ggc gaa gcc tcc aag tat aca gaa gag     1626
 Glu Gly Val Glu Glu Ser Ser Gly Glu Ala Ser Lys Tyr Thr Glu Glu
         455                 460                 465

 gat cct tcc gga gaa aca ctg tct tca gaa aac aag tcc agc tgg tta     1674
 Asp Pro Ser Gly Glu Thr Leu Ser Ser Glu Asn Lys Ser Ser Trp Leu
     470                 475                 480

 atg acg tct aag cct agt gct cta gct caa gag acc tct ctt ggt gcc     1722
 Met Thr Ser Lys Pro Ser Ala Leu Ala Gln Glu Thr Ser Leu Gly Ala
 485                 490                 495                 500

 cct gag cct ttg tct ggt gaa cag ttg gtt ggt tct ccc cag gat aag     1770
 Pro Glu Pro Leu Ser Gly Glu Gln Leu Val Gly Ser Pro Gln Asp Lys
                 505                 510                 515

 gcg gca gag gct aca aat gac tat gag act ctt gta aag cgt gga aaa     1818
 Ala Ala Glu Ala Thr Asn Asp Tyr Glu Thr Leu Val Lys Arg Gly Lys
             520                 525                 530

 gaa cta aaa gag tgt gga aaa atc cag gag gcc cta aac tgc tta gtt     1866
 Glu Leu Lys Glu Cys Gly Lys Ile Gln Glu Ala Leu Asn Cys Leu Val
         535                 540                 545

 aaa gcg ctt gac ata aaa agt gca gat cct gaa gtt atg ctc ttg act     1914
 Lys Ala Leu Asp Ile Lys Ser Ala Asp Pro Glu Val Met Leu Leu Thr
     550                 555                 560

 tta agt ttg tat aag caa ctt aat aac aat t gagaatgtaa cctgtttatt     1965
 Leu Ser Leu Tyr Lys Gln Leu Asn Asn Asn 
 565                 570

 gtattttaaa gtgaaactga atatgaggga atttttgttc ccataattgg attctttggg   2025

 aacatgaagc attcaggctt aaggcaagaa agatctcaaa aagcaacttc tgccctgcaa   2085

 cgccccccac tccatagtct ggtattctga gcactagctt aatatttctt cacttgaata   2145

 ttcttatatt ttaggcatat tctataaatt taactgtgtt gtttcttgga aagttttgta   2205

 aaattattct ggtcattctt aattttactc tgaaagtgat catctttgta tataacagtt   2265

 cagataagaa aattaaagtt acttttctca aaaaaaaaaa a                       2306




      <210> 169
      <211> 1537
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (64)..(1248)

      <400> 169
 tcatccaaat ccttctctct gaaggcacta cagaaccacg tcggggaagc tcttccccca     60

 gag  atg gtc acc agg ctg tat gat ggc atg cgg agg gtc gac ctg aca     108
      Met Val Thr Arg Leu Tyr Asp Gly Met Arg Arg Val Asp Leu Thr
        1               5                  10                  15

 ggg aag gcg aag gga ccc agt gag aac gtg tcc cag gag cag ttc aca      156
 Gly Lys Ala Lys Gly Pro Ser Glu Asn Val Ser Gln Glu Gln Phe Thr
                  20                  25                  30

 gca tcc atg tcc cac ctg ttg aaa gga aac tcc gag gag aag agt ctc      204
 Ala Ser Met Ser His Leu Leu Lys Gly Asn Ser Glu Glu Lys Ser Leu
              35                  40                  45

 atg att atg aaa atg att tct gcc aca gaa ggt ccc gtg aag gcc aga      252
 Met Ile Met Lys Met Ile Ser Ala Thr Glu Gly Pro Val Lys Ala Arg
          50                  55                  60

 gaa gtc caa aag ttt aca gag gat ctg gtt ggc tct gtg gtg cac gtg      300
 Glu Val Gln Lys Phe Thr Glu Asp Leu Val Gly Ser Val Val His Val
      65                  70                  75

 cta agc cac aga cag gag ctg aga ggc tgg act ggg aag gaa gcc cca      348
 Leu Ser His Arg Gln Glu Leu Arg Gly Trp Thr Gly Lys Glu Ala Pro
  80                  85                  90                  95

 ggg ccc aac ccc cgg gtg cag gtg ctg gct gct cag ctg ctc tct gag      396
 Gly Pro Asn Pro Arg Val Gln Val Leu Ala Ala Gln Leu Leu Ser Glu
                 100                 105                 110

 atg aag ctg caa gat ggc aag aga ctt ctg ggg ccc cag tgg ctg gac      444
 Met Lys Leu Gln Asp Gly Lys Arg Leu Leu Gly Pro Gln Trp Leu Asp
             115                 120                 125

 tat gac tgt gac cga gct gtg atc gag gac tgg gtg ttc agg gtc ccc      492
 Tyr Asp Cys Asp Arg Ala Val Ile Glu Asp Trp Val Phe Arg Val Pro
         130                 135                 140

 cat gtg gcc ata ttc ctg agt gtg gtc att tgc aag ggc ttt ctc gtc      540
 His Val Ala Ile Phe Leu Ser Val Val Ile Cys Lys Gly Phe Leu Val
     145                 150                 155

 ctg tgc tcg tct ctt gat ctg act acc ctg gtc cct gag cgt caa gtg      588
 Leu Cys Ser Ser Leu Asp Leu Thr Thr Leu Val Pro Glu Arg Gln Val
 160                 165                 170                 175

 gac cag ggc agg ggt ttt gag agc atc ctg gat gtc ctc tct gtc atg      636
 Asp Gln Gly Arg Gly Phe Glu Ser Ile Leu Asp Val Leu Ser Val Met
                 180                 185                 190

 tac atc aac gcc cag ctg cct cgg gag cag cgg cac cgc tgg cgc ctg      684
 Tyr Ile Asn Ala Gln Leu Pro Arg Glu Gln Arg His Arg Trp Arg Leu
             195                 200                 205

 ctc ttt tcg tct gag ctc cat gga cac agc ttc tcc cag ctc tgt ggc      732
 Leu Phe Ser Ser Glu Leu His Gly His Ser Phe Ser Gln Leu Cys Gly
         210                 215                 220

 cac atc act cac cgg ggg ccc tgt gtg gct gtc ctc gag gac cat gac      780
 His Ile Thr His Arg Gly Pro Cys Val Ala Val Leu Glu Asp His Asp
     225                 230                 235

 aag cat gtg ttc gga ggg ttt gcc tct tgc tct tgg gag gtg aag cct      828
 Lys His Val Phe Gly Gly Phe Ala Ser Cys Ser Trp Glu Val Lys Pro
 240                 245                 250                 255

 cag ttt caa ggg gac aac aga tgc ttc ctg ttc tcc atc tgc ccc agc      876
 Gln Phe Gln Gly Asp Asn Arg Cys Phe Leu Phe Ser Ile Cys Pro Ser
                 260                 265                 270

 atg gct gtg tac aca cac acg ggc tac aac gac cac tac atg tac ttg      924
 Met Ala Val Tyr Thr His Thr Gly Tyr Asn Asp His Tyr Met Tyr Leu
             275                 280                 285

 aac cat gga cag cag acg atc ccg aac gga ctg ggt atg ggg ggg cag      972
 Asn His Gly Gln Gln Thr Ile Pro Asn Gly Leu Gly Met Gly Gly Gln
         290                 295                 300

 cac aat tac ttt ggg ctt tgg gtg gat gtt gat ttt ggg aaa gga cac     1020
 His Asn Tyr Phe Gly Leu Trp Val Asp Val Asp Phe Gly Lys Gly His
     305                 310                 315

 agc aga gcc aag ccc acg tgc acc acg tac aac agc ccg cag ctg tcg     1068
 Ser Arg Ala Lys Pro Thr Cys Thr Thr Tyr Asn Ser Pro Gln Leu Ser
 320                 325                 330                 335

 gct cag gag aac ttc cag ttt gat aag atg gag gtg tgg gcg gtt gga     1116
 Ala Gln Glu Asn Phe Gln Phe Asp Lys Met Glu Val Trp Ala Val Gly
                 340                 345                 350

 gac ccc tca gag gag cag ttg gcc aag ggc aac aag agc atc ctg gat     1164
 Asp Pro Ser Glu Glu Gln Leu Ala Lys Gly Asn Lys Ser Ile Leu Asp
             355                 360                 365

 gcg gac cct gag gcc cag gcc ctg ctg gag atc agt ggg cat tcg cgc     1212
 Ala Asp Pro Glu Ala Gln Ala Leu Leu Glu Ile Ser Gly His Ser Arg
         370                 375                 380

 cac agc gaa ggg ctc cgg gaa gtc ccg gac gat gaa tgag gagccgcctg     1262
 His Ser Glu Gly Leu Arg Glu Val Pro Asp Asp Glu 
     385                 390                 395

 agccttcctg gagccaggac ctggattcct ctgggtagag ggcaccgcct gcagcccctc   1322

 ttccctccca catggtttaa ctgtaatagc gtaccgcacg ggtcacagcc tggtagtccc   1382

 acatgtgcca agaagacgcc ctctgaagcc atgtcctgac tcatgggtgg atctcccaga   1442

 aatagatgtt ttttaagttt tcttttttgc cctacagggt caccctcagg atctctccaa   1502

 gaaatcttgt gtcaaattag taaaaaaaaa aaaaa                              1537




      <210> 170
      <211> 2222
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (100)..(1782)

      <400> 170
 tgagataaag acttaattcg ggccacctca ggagctgcca cccctgtcat agcattttta     60

 ttatcaaatc tggcactcac aagccctggc cgaccccca   atg ggt ttt acc act     114
                                              Met Gly Phe Thr Thr
                                                1               5

 ccc cct cta gac cct gtc ttg caa aat cct ctc cct agc cag cta gta      162
 Pro Pro Leu Asp Pro Val Leu Gln Asn Pro Leu Pro Ser Gln Leu Val
                  10                  15                  20

 ttt tct ggg cta aag act gta caa cca gtt cct cca ttt tat aga agt      210
 Phe Ser Gly Leu Lys Thr Val Gln Pro Val Pro Pro Phe Tyr Arg Ser
              25                  30                  35

 tta ctc act cca ggg gaa atg gtg agt cct cca acc tcc ctc cca acc      258
 Leu Leu Thr Pro Gly Glu Met Val Ser Pro Pro Thr Ser Leu Pro Thr
          40                  45                  50

 agt ccc atc att cca acc agt ggt acc ata gag cag cac ccc ccg cca      306
 Ser Pro Ile Ile Pro Thr Ser Gly Thr Ile Glu Gln His Pro Pro Pro
      55                  60                  65

 ccc tct gag cca gta gtg cca gca gtg atg atg gcc acc cat gag ccc      354
 Pro Ser Glu Pro Val Val Pro Ala Val Met Met Ala Thr His Glu Pro
  70                  75                  80                  85

 agt gct gac ctg gca ccc aag aaa aag ccc agg aag tca agc atg cct      402
 Ser Ala Asp Leu Ala Pro Lys Lys Lys Pro Arg Lys Ser Ser Met Pro
                  90                  95                 100

 gtg aag att gag aag gaa att att gat acc gcc gat gag ttt gat gat      450
 Val Lys Ile Glu Lys Glu Ile Ile Asp Thr Ala Asp Glu Phe Asp Asp
             105                 110                 115

 gaa gat gat gac ccc aat gat ggt gga gct gtg gtc aat gac atg agc      498
 Glu Asp Asp Asp Pro Asn Asp Gly Gly Ala Val Val Asn Asp Met Ser
         120                 125                 130

 cat gac aat cat tgt cac tcc caa gag gag atg agc cca ggc atg tct      546
 His Asp Asn His Cys His Ser Gln Glu Glu Met Ser Pro Gly Met Ser
     135                 140                 145

 gtg aag gac ttt tct aag cat aac agg acc cgg tgc att tca agg act      594
 Val Lys Asp Phe Ser Lys His Asn Arg Thr Arg Cys Ile Ser Arg Thr
 150                 155                 160                 165

 gaa ata agg agg gcc gac agc atg act tct gaa gac caa gaa cct gag      642
 Glu Ile Arg Arg Ala Asp Ser Met Thr Ser Glu Asp Gln Glu Pro Glu
                 170                 175                 180

 cgg gac tat gag aac gag tct gag tct tcg gag ccc aaa ctg ggc gag      690
 Arg Asp Tyr Glu Asn Glu Ser Glu Ser Ser Glu Pro Lys Leu Gly Glu
             185                 190                 195

 gaa tcc atg gaa ggg gat gag cac att cac agc gaa gtg agt gaa aaa      738
 Glu Ser Met Glu Gly Asp Glu His Ile His Ser Glu Val Ser Glu Lys
         200                 205                 210

 gtc ctg atg aat agt gag agg cct gat gag aac cac agt gag ccc tct      786
 Val Leu Met Asn Ser Glu Arg Pro Asp Glu Asn His Ser Glu Pro Ser
     215                 220                 225

 cac cag gac gtc atc aag gtg aag gaa gaa ttt aca gac ccc act tac      834
 His Gln Asp Val Ile Lys Val Lys Glu Glu Phe Thr Asp Pro Thr Tyr
 230                 235                 240                 245

 gac atg ttt tac atg agc cag tat gga ctg tac aat ggt ggg ggt gcc      882
 Asp Met Phe Tyr Met Ser Gln Tyr Gly Leu Tyr Asn Gly Gly Gly Ala
                 250                 255                 260

 agc atg gcc gcc ttg cat gag agc ttt aca tcg tct ctg aat tat ggc      930
 Ser Met Ala Ala Leu His Glu Ser Phe Thr Ser Ser Leu Asn Tyr Gly
             265                 270                 275

 agc cct caa aag ttc tcc cca gaa ggt gac cta tgt tct agc cca gac      978
 Ser Pro Gln Lys Phe Ser Pro Glu Gly Asp Leu Cys Ser Ser Pro Asp
         280                 285                 290

 ccc aaa atc tgt tat gtg tgc aag aag agt ttc aaa agc tcc tac agt     1026
 Pro Lys Ile Cys Tyr Val Cys Lys Lys Ser Phe Lys Ser Ser Tyr Ser
     295                 300                 305

 gtg aaa ctt cac tac agg aac gtt cac ttg aaa gag atg cac gtc tgc     1074
 Val Lys Leu His Tyr Arg Asn Val His Leu Lys Glu Met His Val Cys
 310                 315                 320                 325

 aca gtg gct ggt tgc aat gct gca ttc ccc tct cgc cga agc cga gac     1122
 Thr Val Ala Gly Cys Asn Ala Ala Phe Pro Ser Arg Arg Ser Arg Asp
                 330                 335                 340

 aga cac agt gcc aac ata aac cta cat cgt aaa ctg ttg acc aaa gaa     1170
 Arg His Ser Ala Asn Ile Asn Leu His Arg Lys Leu Leu Thr Lys Glu
             345                 350                 355

 ctc gat gac atg ggc ctg gac tcg tcg cag ccc tcc ctt agc aag gac     1218
 Leu Asp Asp Met Gly Leu Asp Ser Ser Gln Pro Ser Leu Ser Lys Asp
         360                 365                 370

 ctc cgc gat gaa ttt ttg gtg aag ata tat ggt gcc cag cac ccc atg     1266
 Leu Arg Asp Glu Phe Leu Val Lys Ile Tyr Gly Ala Gln His Pro Met
     375                 380                 385

 ggg ctc gat gtc agg gaa gac gcc tcc tct ccc gca ggg act gaa gac     1314
 Gly Leu Asp Val Arg Glu Asp Ala Ser Ser Pro Ala Gly Thr Glu Asp
 390                 395                 400                 405

 tcc cac ctg aac ggg tat ggg aga ggc atg gca gag gac tac atg gtc     1362
 Ser His Leu Asn Gly Tyr Gly Arg Gly Met Ala Glu Asp Tyr Met Val
                 410                 415                 420

 ctt gac ttg agc acc acc tcc agc ctc cag tcc agc agc agt atc cat     1410
 Leu Asp Leu Ser Thr Thr Ser Ser Leu Gln Ser Ser Ser Ser Ile His
             425                 430                 435

 tcc tcc aga gaa tcc gac gca ggc agc gat gag ggg att ctt ctc gat     1458
 Ser Ser Arg Glu Ser Asp Ala Gly Ser Asp Glu Gly Ile Leu Leu Asp
         440                 445                 450

 gac att gac ggg gcg agt gac agt ggg gag tcg gca cac aag gcc gag     1506
 Asp Ile Asp Gly Ala Ser Asp Ser Gly Glu Ser Ala His Lys Ala Glu
     455                 460                 465

 gcc cct gcc ctc cct ggc agc cta ggg gct gaa gtt tca gga tct ctt     1554
 Ala Pro Ala Leu Pro Gly Ser Leu Gly Ala Glu Val Ser Gly Ser Leu
 470                 475                 480                 485

 atg ttc agc agc ttg tct ggg agc aat ggt ggg atc atg tgc aac att     1602
 Met Phe Ser Ser Leu Ser Gly Ser Asn Gly Gly Ile Met Cys Asn Ile
                 490                 495                 500

 tgc cac aaa atg tac agc aac aag ggg acc ctg aga gtg cac tac aaa     1650
 Cys His Lys Met Tyr Ser Asn Lys Gly Thr Leu Arg Val His Tyr Lys
             505                 510                 515

 act gtg cat ttg aga gaa atg cac aag tgc aaa gtc cca ggt tgc aat     1698
 Thr Val His Leu Arg Glu Met His Lys Cys Lys Val Pro Gly Cys Asn
         520                 525                 530

 atg atg ttt tcc tct gta cga agc cga aat cgg cac agt cag aac cct     1746
 Met Met Phe Ser Ser Val Arg Ser Arg Asn Arg His Ser Gln Asn Pro
     535                 540                 545

 aat ctc cac aaa aac att ccc ttc act tca gta gat tagt ctcagaatgg     1796
 Asn Leu His Lys Asn Ile Pro Phe Thr Ser Val Asp 
 550                 555                 560

 acactacaaa tgccagctct caccagatgg cctacgtgtt tgaactgcca tagtcagtgt   1856

 gcgcttatgt acttggggtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgcatttatg   1916

 tatgctctgt ggctacatat acacacacgt atttccttga gataaacaag ataaacacta   1976

 ggtgcttttg aatttttttc acttcccttt atagttttgg gaaaggagtg ggatctttga   2036

 tttcagggtg aaaacagagt acccctttaa acacacacac acacacatgc acatacacac   2096

 acacacacac acacacacac agtgtgcaac tagccccagt tttgacagaa taattcttgg   2156

 tcttccccaa agagacaatt tgttgtaccc atgactgttg cctgcaaaaa taaaagggaa   2216

 aaaaaa                                                              2222




      <210> 171
      <211> 1058
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (403)..(714)

      <400> 171
 ccaggaccgt cggagggcac agctctgtga cggcgctctc tgtgtgtctc gcacctgccc     60

 tgtgtggatt cctggcttta actaaacgca gcctctcatc ctcagcacgc gtgtcagagg    120

 aggaggagct ggaggccctc tcagtggcca gcacctgcca gcttgtctgg gactctccag    180

 cagctgccgg gaggcatcgt gtgtgtgtca cctgtcactc cctggacggc aagtgccagc    240

 tgaagcgcag agccctcgcc cgcctactat gagttcatcg gcgtcagcgg ctgccaggac    300

 gtgctgcacc tgtaccgcct gctctgggcc tctgcagttc tgaacgtcct gggcctgttc    360

 ctgggcatca tcaccgccgc cgtcctgggg gccttcaagg ac   atg gtg cct ctg     414
                                                  Met Val Pro Leu
                                                    1

 tcc cag ctg gcc tat ggc cca gcc gtc cca cca cag acc ctc tac aac      462
 Ser Gln Leu Ala Tyr Gly Pro Ala Val Pro Pro Gln Thr Leu Tyr Asn
   5                  10                  15                  20

 ccc gcc cag cag atc ctg gcc tac gca ggc ttc cgc ctg acg ccc gag      510
 Pro Ala Gln Gln Ile Leu Ala Tyr Ala Gly Phe Arg Leu Thr Pro Glu
                  25                  30                  35

 ccc gtc ccg acc tgc tcg tcc tac cct ctg ccc ctt cag ccc tgc agc      558
 Pro Val Pro Thr Cys Ser Ser Tyr Pro Leu Pro Leu Gln Pro Cys Ser
              40                  45                  50

 cgc ttc cca gtt gcg ccc tcc tct gcc ctg gct tcg tct gag gac ctg      606
 Arg Phe Pro Val Ala Pro Ser Ser Ala Leu Ala Ser Ser Glu Asp Leu
          55                  60                  65

 cag ccc cct tct cca agc agc tct ggc tct ggg ctt ccc ggc cag gct      654
 Gln Pro Pro Ser Pro Ser Ser Ser Gly Ser Gly Leu Pro Gly Gln Ala
      70                  75                  80

 cca ccg tgc tac gca ccc acc tac ttt ccc ccg ggg gag aag cca ccc      702
 Pro Pro Cys Tyr Ala Pro Thr Tyr Phe Pro Pro Gly Glu Lys Pro Pro
  85                  90                  95                 100

 ccc tac gca ccc tga tagaggcgtg gagtaaaaga taacttgttt gttttttttt      757
 Pro Tyr Ala Pro 


 ttaaaaaaaa ggcagcctct agaaatcccg cttctgtggc caacctccta gagaacccgg    817

 gagaatgttc cagaagtctg tcccctcctt tcctccctgg gcacactggt gagggaggct    877

 ggaaccaggc agggagtggg gccctccaga cccaggctgg tgacaccttg gcttgggctc    937

 tgctcacatc aaatggcgct gaaagttccc acccggcctc ctcctctgag agcaattgtt    997

 ctggtgtttt cacatccctt aattaattag ctattattat gattttgcaa aaaaaaaaaa   1057

 a                                                                   1058




      <210> 172
      <211> 3629
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (449)..(2044)

      <400> 172
 aggagaagat gtgccgccgc tgccaacgtc gagcggcgac ggctgggaaa aagatcttga     60

 agaagctctg gaagcaggag gttgtgatct tgaaacgttg agaaatataa ttcaaggaag    120

 accgctgcct gctgatctga gggccaaagt ttggaagatt gctctgaatg ttgcaggaaa    180

 aggtgatagt ttggcatcat gggatggtat tttagacttg ccagaacaga acactattca    240

 caaagattgc ctgcagttta ttgaccagct ttcagtgcca gaggagaagg cagcagaatt    300

 acttttggat attgaatctg taattacctt ttattgtaaa tcacgtaaca ttaaatatag    360

 cacatccctt agctggatac atctactgaa accattggtg catcttcaac tgccacgcag    420

 cgatttatac aactgctttt atgccata   atg aat aag tac att ccc agg gat     472
                                  Met Asn Lys Tyr Ile Pro Arg Asp
                                    1               5

 tgt tcc cag aaa ggg aga cca ttt cat ctc ttc agg ttg ctc atc caa      520
 Cys Ser Gln Lys Gly Arg Pro Phe His Leu Phe Arg Leu Leu Ile Gln
      10                  15                  20

 tac cat gag cct gag ctt tgt tct tat ctt gat aca aag aaa att act      568
 Tyr His Glu Pro Glu Leu Cys Ser Tyr Leu Asp Thr Lys Lys Ile Thr
  25                  30                  35                  40

 cca gac tcc tat gca ctc aac tgg ctt gga agt ctt ttt gca tgt tac      616
 Pro Asp Ser Tyr Ala Leu Asn Trp Leu Gly Ser Leu Phe Ala Cys Tyr
                  45                  50                  55

 tgt tcc act gaa gtc act cag gca ata tgg gat gga tat cta caa caa      664
 Cys Ser Thr Glu Val Thr Gln Ala Ile Trp Asp Gly Tyr Leu Gln Gln
              60                  65                  70

 gca gat cca ttt ttt att tat ttc tta atg tta att atc ctt gtt aat      712
 Ala Asp Pro Phe Phe Ile Tyr Phe Leu Met Leu Ile Ile Leu Val Asn
          75                  80                  85

 gca aaa gaa gtt att tta aca caa gag tca gac agc aaa gaa gaa gtt      760
 Ala Lys Glu Val Ile Leu Thr Gln Glu Ser Asp Ser Lys Glu Glu Val
      90                  95                 100

 atc aag ttc ttg gaa aat act cca tcc agt ctg aat ata gaa gat ata      808
 Ile Lys Phe Leu Glu Asn Thr Pro Ser Ser Leu Asn Ile Glu Asp Ile
 105                 110                 115                 120

 gaa gac ctt ttc tct ctg gct cag tat tat tgc agc aaa aca ccg gct      856
 Glu Asp Leu Phe Ser Leu Ala Gln Tyr Tyr Cys Ser Lys Thr Pro Ala
                 125                 130                 135

 tct ttt agg aag gat aat cac cat ctc ttt ggt agt act ttg ttg gga      904
 Ser Phe Arg Lys Asp Asn His His Leu Phe Gly Ser Thr Leu Leu Gly
             140                 145                 150

 att aag gat gat gat gca gat ctg agt cag gct ctt tgt ctg gcc atc      952
 Ile Lys Asp Asp Asp Ala Asp Leu Ser Gln Ala Leu Cys Leu Ala Ile
         155                 160                 165

 tcc gtg tca gag atc ctt caa gcg aat cag cta caa ggg gaa gga gtc     1000
 Ser Val Ser Glu Ile Leu Gln Ala Asn Gln Leu Gln Gly Glu Gly Val
     170                 175                 180

 cgg ttc ttt gtg gtg gat tgc cgt cct gca gaa caa tat aat gct ggg     1048
 Arg Phe Phe Val Val Asp Cys Arg Pro Ala Glu Gln Tyr Asn Ala Gly
 185                 190                 195                 200

 cat tta tca act gct ttc cac tta gat tca gac ctg atg ctt cag aat     1096
 His Leu Ser Thr Ala Phe His Leu Asp Ser Asp Leu Met Leu Gln Asn
                 205                 210                 215

 cca tct gag ttt gca cag tca gta aaa tcc ttg ctg gaa gca cag aag     1144
 Pro Ser Glu Phe Ala Gln Ser Val Lys Ser Leu Leu Glu Ala Gln Lys
             220                 225                 230

 cag tcc att gag tct ggc tcc ata gct ggt ggg gag cac ctc tgt ttt     1192
 Gln Ser Ile Glu Ser Gly Ser Ile Ala Gly Gly Glu His Leu Cys Phe
         235                 240                 245

 atg ggc agt ggc agg gag gaa gaa gac atg tat atg aac atg gtc ctg     1240
 Met Gly Ser Gly Arg Glu Glu Glu Asp Met Tyr Met Asn Met Val Leu
     250                 255                 260

 gca cac ttt tta cag aaa aac aaa gaa tat gtg agt att gcc agt gga     1288
 Ala His Phe Leu Gln Lys Asn Lys Glu Tyr Val Ser Ile Ala Ser Gly
 265                 270                 275                 280

 gga ttt atg gca ctg cag cag cac ctg gca gac att aat gtg gat gga     1336
 Gly Phe Met Ala Leu Gln Gln His Leu Ala Asp Ile Asn Val Asp Gly
                 285                 290                 295

 cca gaa aat gga tat ggc cat tgg att gct agt acc tca ggc tca agg     1384
 Pro Glu Asn Gly Tyr Gly His Trp Ile Ala Ser Thr Ser Gly Ser Arg
             300                 305                 310

 agc agt atc aat tct gtt gat ggt gaa tct cct aat ggc tca agt gat     1432
 Ser Ser Ile Asn Ser Val Asp Gly Glu Ser Pro Asn Gly Ser Ser Asp
         315                 320                 325

 aga gga atg aaa tca cta gta aat aaa atg act gtg gct ttg aag aca     1480
 Arg Gly Met Lys Ser Leu Val Asn Lys Met Thr Val Ala Leu Lys Thr
     330                 335                 340

 aaa tcc gtt aat gtc agg gaa aaa gtt atc agt ttt ata gag aat aca     1528
 Lys Ser Val Asn Val Arg Glu Lys Val Ile Ser Phe Ile Glu Asn Thr
 345                 350                 355                 360

 tca act cct gtg gat cgg cat gtg agc agc agt gac aga gtg ggc aag     1576
 Ser Thr Pro Val Asp Arg His Val Ser Ser Ser Asp Arg Val Gly Lys
                 365                 370                 375

 cct tac cgt ggc gta aag cct gtt ttc agc att ggg gat gaa gaa gaa     1624
 Pro Tyr Arg Gly Val Lys Pro Val Phe Ser Ile Gly Asp Glu Glu Glu
             380                 385                 390

 tac gac aca gat gaa att gac agt tct tca atg tca gat gat gat aga     1672
 Tyr Asp Thr Asp Glu Ile Asp Ser Ser Ser Met Ser Asp Asp Asp Arg
         395                 400                 405

 aaa gag gtt gta aac att cag act tgg ata aac aaa cca gat gtc aaa     1720
 Lys Glu Val Val Asn Ile Gln Thr Trp Ile Asn Lys Pro Asp Val Lys
     410                 415                 420

 cat cat ttt cct tgt aaa gaa gta aaa gaa agt gga cac atg ttt ccc     1768
 His His Phe Pro Cys Lys Glu Val Lys Glu Ser Gly His Met Phe Pro
 425                 430                 435                 440

 agt cat ctg ttg gtt act gca aca cat atg tac tgt tta agg gag att     1816
 Ser His Leu Leu Val Thr Ala Thr His Met Tyr Cys Leu Arg Glu Ile
                 445                 450                 455

 gtt tca cgg aaa gga ttg gct tat ata cag tct cga caa gcg ctg aat     1864
 Val Ser Arg Lys Gly Leu Ala Tyr Ile Gln Ser Arg Gln Ala Leu Asn
             460                 465                 470

 tct gta gtt aaa att aca tcc aaa aaa aaa cat cct gaa ctc att acc     1912
 Ser Val Val Lys Ile Thr Ser Lys Lys Lys His Pro Glu Leu Ile Thr
         475                 480                 485

 ttc aag tat gga aat agc agt gct tca gga ata gaa atc ttg gca atc     1960
 Phe Lys Tyr Gly Asn Ser Ser Ala Ser Gly Ile Glu Ile Leu Ala Ile
     490                 495                 500

 gaa agg tat ttg att cca aat gca ggg gat gca act aaa gcc ata aaa     2008
 Glu Arg Tyr Leu Ile Pro Asn Ala Gly Asp Ala Thr Lys Ala Ile Lys
 505                 510                 515                 520

 cag cag atc atg aaa gtt ttg gat gct ttg gaa agt taat ataaaagaaa     2058
 Gln Gln Ile Met Lys Val Leu Asp Ala Leu Glu Ser 
                 525                 530

 attatataaa aagaaattaa gacaaccaag agaaacatgg acatatacct cctgactgaa   2118

 tactaactgg agacctttca tttgctcatg gggctgctta aatagcaggt ctaagaaagt   2178

 gtaaattatt ataatcaatc tgtggacagt aaacttttta aaaatttttc ttctgcattt   2238

 ttggttttat aaaatgatgt attataaagg tcagttatta aattactttg aagtaactga   2298

 ccctgtgccc ttatggacta agtaagggta cagaatgcag ttctgttttg aagagctgtt   2358

 ttaagggaac atgcatcact ttcgggttca aaaacaactg tacacataca tatctgcagt   2418

 gtcttcactg aaaattagag atagaattag ttgaagagac ttccttaatt gctacattgt   2478

 tttactcact gagcaatatc agaaactaaa acatagatta ataattcact cactgtttct   2538

 attcttctta aaaagagtga aatcttttta atggaatggt tgaagattcc tgccaactca   2598

 aaatacagta cagctagtaa aatgttgaaa catcagtttc taaatcacct ttgctccatt   2658

 agctaatttt ttggacacta aatgcttcaa agataagaaa cttcatccta atgatttcta   2718

 aagagcagtt aaaagcatta aaataagtag gtaggctgtt aagattaaaa ttaacatttt   2778

 ggggacagaa ttgtgtctgt aaaaatgtca ttggttttat tacaagtgga ttattttatt   2838

 catattttaa aacaaatgtt taagccacat tgatttatcc tcattgagga ttatggtctg   2898

 tgaccacagt aatatccact tatataaatg ccaaataatc agagagctta taaagtacaa   2958

 ttgtttttgt catcattttc tgaatttctt tctcttcttt tggttttgtc ctctcattga   3018

 agttccagtg gtttgaaatt agttttggac acattgtctt aatgtactga aaattgctct   3078

 gctgtatttt gcagcgttct tcatttaatt tataatggtc catattagac acatttggta   3138

 agagaagtcc aggaacacat ttagggccat ggaatagtat tttgtaaaat ccatttggga   3198

 agttgcaata cccacaatct gacatgtcct aaaatgtaag ggattatctc taaggggttg   3258

 atgggagaaa tatttagatg taccctgtta acagccagtc attttgattt acttatggaa   3318

 atcaagtgaa taaaaggcaa cataatttgg gaaattttat tctaatatct aataaaaaca   3378

 gtttgagtgg ttgaagacat ctgcatgaaa ttgcacctag gtgcattact tgatataact   3438

 ctcccctaaa actgttgtaa ttgcattttt tcccttttct tggcacccct ttagaaatgt   3498

 actgaagtct catttttcac ccatttcagc catgggacat ttttcataat attaatgtaa   3558

 agatgtttgt gttactgttt ataaattaca attgtaaata aattactagt ttgcccaaaa   3618

 aaaaaaaaaa a                                                        3629




      <210> 173
      <211> 1810
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (71)..(1180)

      <400> 173
 taagcttgcg gccgcctctg ctctcagtgc cccggatcgg aggccgtcca tcgcccctcg     60

 ggccgacgcc   atg aag atc aaa gat gcc aag aaa ccc tct ttc cca tgg     109
              Met Lys Ile Lys Asp Ala Lys Lys Pro Ser Phe Pro Trp
                1               5                  10

 ttt ggc atg gac att ggg gga act cta gta aag ctc tcg tac ttt gaa      157
 Phe Gly Met Asp Ile Gly Gly Thr Leu Val Lys Leu Ser Tyr Phe Glu
      15                  20                  25

 cct att gat atc aca gca gag gaa gag caa gaa gaa gtt gag agt tta      205
 Pro Ile Asp Ile Thr Ala Glu Glu Glu Gln Glu Glu Val Glu Ser Leu
  30                  35                  40                  45

 aaa agt att cgg aaa tat ttg act tct aac gtg gca tat gga tcc acc      253
 Lys Ser Ile Arg Lys Tyr Leu Thr Ser Asn Val Ala Tyr Gly Ser Thr
                  50                  55                  60

 ggc att cgg gat gta cac ctt gaa ctg aaa gat tta aca ctt ttt ggc      301
 Gly Ile Arg Asp Val His Leu Glu Leu Lys Asp Leu Thr Leu Phe Gly
              65                  70                  75

 cga aga ggg aac ttg cac ttt atc agg ttt cca acc cag gac ctg cct      349
 Arg Arg Gly Asn Leu His Phe Ile Arg Phe Pro Thr Gln Asp Leu Pro
          80                  85                  90

 act ttt atc caa atg gga aga gat aaa aac ttc tca aca ttg cag acg      397
 Thr Phe Ile Gln Met Gly Arg Asp Lys Asn Phe Ser Thr Leu Gln Thr
      95                 100                 105

 gtg cta tgt gct aca gga ggt ggt gct tac aag ttt gaa aaa gat ttt      445
 Val Leu Cys Ala Thr Gly Gly Gly Ala Tyr Lys Phe Glu Lys Asp Phe
 110                 115                 120                 125

 cgc aca att gga aac ctc cac ctg cac aaa ctg gat gaa ctt gac tgc      493
 Arg Thr Ile Gly Asn Leu His Leu His Lys Leu Asp Glu Leu Asp Cys
                 130                 135                 140

 ctt gta aag ggc ttg ctg tat ata gac tct gtc agt ttc aat gga caa      541
 Leu Val Lys Gly Leu Leu Tyr Ile Asp Ser Val Ser Phe Asn Gly Gln
             145                 150                 155

 gcc gag tgc tat tat ttt gct aat gcc tca gaa cct gag cga tgc caa      589
 Ala Glu Cys Tyr Tyr Phe Ala Asn Ala Ser Glu Pro Glu Arg Cys Gln
         160                 165                 170

 aag atg cct ttt aac ctg gat gat ccc tat cca ctg ctt gta gtg aac      637
 Lys Met Pro Phe Asn Leu Asp Asp Pro Tyr Pro Leu Leu Val Val Asn
     175                 180                 185

 att ggc tca gga gtc agt att tta gca gtc cat tcc aaa gac aac tat      685
 Ile Gly Ser Gly Val Ser Ile Leu Ala Val His Ser Lys Asp Asn Tyr
 190                 195                 200                 205

 aaa cga gtg act ggg aca agc ctt gga ggg ggt acc ttt ctg ggt tta      733
 Lys Arg Val Thr Gly Thr Ser Leu Gly Gly Gly Thr Phe Leu Gly Leu
                 210                 215                 220

 tgc agt tta ttg act ggc tgt gaa agt ttt gaa gag gct ctt gaa atg      781
 Cys Ser Leu Leu Thr Gly Cys Glu Ser Phe Glu Glu Ala Leu Glu Met
             225                 230                 235

 gca tcc aaa ggt gat agc aca caa gct gac aag ctg gtc cgt gat att      829
 Ala Ser Lys Gly Asp Ser Thr Gln Ala Asp Lys Leu Val Arg Asp Ile
         240                 245                 250

 tat gga gga gat tat gaa aga ttt ggt ttg cca ggt tgg gct gta gca      877
 Tyr Gly Gly Asp Tyr Glu Arg Phe Gly Leu Pro Gly Trp Ala Val Ala
     255                 260                 265

 tct agt ttt ggg aat atg att tat aag gag aag cga gaa tct gtt agt      925
 Ser Ser Phe Gly Asn Met Ile Tyr Lys Glu Lys Arg Glu Ser Val Ser
 270                 275                 280                 285

 aaa gaa gat ctg gca aga gct act tta gtt act atc acc aat aac att      973
 Lys Glu Asp Leu Ala Arg Ala Thr Leu Val Thr Ile Thr Asn Asn Ile
                 290                 295                 300

 ggt tct gtg gca cga atg tgt gct gtt aat gag aaa ata aac aga gtt     1021
 Gly Ser Val Ala Arg Met Cys Ala Val Asn Glu Lys Ile Asn Arg Val
             305                 310                 315

 gtc ttt gtt gga aac ttt tta cgt gtc aat acc ctc tca atg aaa ctt     1069
 Val Phe Val Gly Asn Phe Leu Arg Val Asn Thr Leu Ser Met Lys Leu
         320                 325                 330

 ttg gca tat gca ctg gat tac tgg tca aaa ggt caa cta aaa gca ttg     1117
 Leu Ala Tyr Ala Leu Asp Tyr Trp Ser Lys Gly Gln Leu Lys Ala Leu
     335                 340                 345

 ttt cta gaa cat gag ggt tac ttt gga gca gtt ggt gca ctt ctt ggg     1165
 Phe Leu Glu His Glu Gly Tyr Phe Gly Ala Val Gly Ala Leu Leu Gly
 350                 355                 360                 365

 ctg cca aat ttc agc taaagcatca ggtctctctc tctgctaata aatgtcatcc     1220
 Leu Pro Asn Phe Ser 
                 370

 aagaggaact aaaaccagag gcattattac tgcattgttt gtcactggga accaaaggat   1280

 aaaagagtag cataagctgc tgaatgttgc catattaaag gagagaactt ggtaacgtga   1340

 agtatttctc attgaaatgc tttccctttt gtatatagcc agtgttaaat ccttaaatgc   1400

 aatacagcct ctgattattg agcttcctct taaaaagatt tttttatttt atgtagccaa   1460

 cattgcagta ctgtatgctc aaacacaaat cttaaagtat cggaactgtt tagcttatga   1520

 aaataatcga ctctgaatat ttgttacaag tctgttttat gtgttttgat tactagtgag   1580

 cagaaaataa cataccctgt attcaaaatt actgaaatgg caatcaaaga tgatcatttt   1640

 tatgtgattt tagaaatgtt aaggcaatac tactaattat tgtaggtttt tttaacgtat   1700

 cacccaaagc atgtatgtga tctttcccca ttagtatctt tttctcaaat gccataatta   1760

 actgaaatac tattattaaa ttttcatgag aattctaaaa aaaaaaaaaa              1810




      <210> 174
      <211> 1753
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (153)..(1172)

      <400> 174
 caccgattta tggtgctgac atcagtggct ccttgtttga tgaaaacact aaacaatgga     60

 atcttgggca cctgggaaca attcaggacc tgctggaaaa ggaatgtggg gttgtcatag    120

 aaggcgtcaa tacaccctac ttgtactttg gc  atg tgg aaa acc acg ttt gct     173
                                      Met Trp Lys Thr Thr Phe Ala
                                        1               5

 tgg cat aca gag gac atg gac ctt tac agc atc aac tac ctg cac ctt      221
 Trp His Thr Glu Asp Met Asp Leu Tyr Ser Ile Asn Tyr Leu His Leu
          10                  15                  20

 ggg gag ccc aaa act tgg tat gtg gtg ccc cca gaa cat ggc cag cgc      269
 Gly Glu Pro Lys Thr Trp Tyr Val Val Pro Pro Glu His Gly Gln Arg
      25                  30                  35

 ctg gaa cgc ctg gcc agg gag ctc ttc cca ggc agt tcc cgg ggt tgt      317
 Leu Glu Arg Leu Ala Arg Glu Leu Phe Pro Gly Ser Ser Arg Gly Cys
  40                  45                  50                  55

 ggg gcc ttc ctg cgg cac aag gtg gcc ctc atc tcg cct aca gtt ctc      365
 Gly Ala Phe Leu Arg His Lys Val Ala Leu Ile Ser Pro Thr Val Leu
                  60                  65                  70

 aag gaa aat ggg att ccc ttc aat cgc ata act cag gag gct gga gag      413
 Lys Glu Asn Gly Ile Pro Phe Asn Arg Ile Thr Gln Glu Ala Gly Glu
              75                  80                  85

 ttc atg gtg acc ttt ccc tat ggc tac cat gct ggc ttc aac cat ggt      461
 Phe Met Val Thr Phe Pro Tyr Gly Tyr His Ala Gly Phe Asn His Gly
          90                  95                 100

 ttc aac tgc gca gag gcc atc aat ttt gcc act ccg cga tgg att gat      509
 Phe Asn Cys Ala Glu Ala Ile Asn Phe Ala Thr Pro Arg Trp Ile Asp
     105                 110                 115

 tat ggc aaa atg gcc tcc cag tgt agc tgt ggg gag gca agg gtg acc      557
 Tyr Gly Lys Met Ala Ser Gln Cys Ser Cys Gly Glu Ala Arg Val Thr
 120                 125                 130                 135

 ttt tcc atg gat gcc ttc gtg cgc atc ctg caa cct gaa cgc tat gac      605
 Phe Ser Met Asp Ala Phe Val Arg Ile Leu Gln Pro Glu Arg Tyr Asp
                 140                 145                 150

 ctg tgg aaa cgt ggg caa gac cgg gca gtt gtg gac cac atg gag ccc      653
 Leu Trp Lys Arg Gly Gln Asp Arg Ala Val Val Asp His Met Glu Pro
             155                 160                 165

 agg gta cca gcc agc caa gag ctg agc acc cag aag gaa gtc cag tta      701
 Arg Val Pro Ala Ser Gln Glu Leu Ser Thr Gln Lys Glu Val Gln Leu
         170                 175                 180

 ccc agg aga gca gcg ctg ggc ctg aga caa ctc cct tcc cac tgg gcc      749
 Pro Arg Arg Ala Ala Leu Gly Leu Arg Gln Leu Pro Ser His Trp Ala
     185                 190                 195

 cgg cat tcc cct tgg cct atg gct gcc cgc agt ggg aca cgg tgc cac      797
 Arg His Ser Pro Trp Pro Met Ala Ala Arg Ser Gly Thr Arg Cys His
 200                 205                 210                 215

 acc ctt gtg tgc tct tca ctc cca cgc cga tct gca gtt agt ggc act      845
 Thr Leu Val Cys Ser Ser Leu Pro Arg Arg Ser Ala Val Ser Gly Thr
                 220                 225                 230

 gct acg cag ccc cgg gct gct gct gtc cac agc tct aag aag ccc agc      893
 Ala Thr Gln Pro Arg Ala Ala Ala Val His Ser Ser Lys Lys Pro Ser
             235                 240                 245

 tca act cca tca tcc acc cct ggt cca tct gca cag att atc cac ccg      941
 Ser Thr Pro Ser Ser Thr Pro Gly Pro Ser Ala Gln Ile Ile His Pro
         250                 255                 260

 tca aat ggc aga cgt ggt cgt ggt cgc cct cct cag aaa ctg aga gct      989
 Ser Asn Gly Arg Arg Gly Arg Gly Arg Pro Pro Gln Lys Leu Arg Ala
     265                 270                 275

 cag gag ctg acc ctc cag act cca gcc aag agg ccc ctc ttg gcg ggc     1037
 Gln Glu Leu Thr Leu Gln Thr Pro Ala Lys Arg Pro Leu Leu Ala Gly
 280                 285                 290                 295

 aca aca tgc aca gct tcg ggc cca gaa cct gag ccc cta cct gag gat     1085
 Thr Thr Cys Thr Ala Ser Gly Pro Glu Pro Glu Pro Leu Pro Glu Asp
                 300                 305                 310

 ggg gct ttg atg gac aag cct gta cca ctg agc cca ggg ctc cag cat     1133
 Gly Ala Leu Met Asp Lys Pro Val Pro Leu Ser Pro Gly Leu Gln His
             315                 320                 325

 cct gtc aag gct tct ggg tgc agc tgg gcc cct gtg ccc taagtccacg      1182
 Pro Val Lys Ala Ser Gly Cys Ser Trp Ala Pro Val Pro 
         330                 335                 340

 ggctgtcttt atatcccact gccctgctgt gtgacagttt gatgaaactg gttacattta   1242

 catcccaaaa ctttggttga gtttgcagga ctctaggcat gcatgaaaga gcccccctgg   1302

 tgatgccctt ggatgctgcc aagtccatgg tagttttcaa ttttgccata cttttgttct   1362

 tcctaccgga ccctggaatg tctttggata ttgctaaaat ctatttctgc agctgaggtt   1422

 ttatccactg gacacatttg tgtgtgagaa ctaggtcttg ttgaggttag cgtaacctgg   1482

 tatatgcaac taccatcctc tgggccaact gtggaagctg ctgcacttgt gaagaatcct   1542

 gagctttgat tcctcttcag tctacgcatt tctctcttcc cctccctcac cccctttttc   1602

 ttataaaact aggttcttta tacagataag gtcagtagag ttccagaata aaagatatga   1662

 cttttctgag ttatttatgt acttaaaata tgttgtcaca gtatttgttc ccaaatatat   1722

 taaaggtaac caaaatgtta aaaaaaaaaa a                                  1753




      <210> 175
      <211> 1042
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (70)..(1017)

      <400> 175
 cgagtgggtc cctgccgctg cgtgggggtg aggggatcag tctggtggaa aggacagagg     60

 actaagtcc    atg gac tgg aaa ttg gaa ggg agt act cag aaa gta gag     108
              Met Asp Trp Lys Leu Glu Gly Ser Thr Gln Lys Val Glu
                1               5                  10

 tca cct gtg ctg cag ggg caa gaa ggc atc cta gag gag aca ggt gaa      156
 Ser Pro Val Leu Gln Gly Gln Glu Gly Ile Leu Glu Glu Thr Gly Glu
      15                  20                  25

 gat gga ctt cct gaa ggc ttc cag ctt ctg cag atc gat gcg gaa ggc      204
 Asp Gly Leu Pro Glu Gly Phe Gln Leu Leu Gln Ile Asp Ala Glu Gly
  30                  35                  40                  45

 gag tgc cag gag gga gag atc ctg gcc aca ggc agt acg gca tgg tgc      252
 Glu Cys Gln Glu Gly Glu Ile Leu Ala Thr Gly Ser Thr Ala Trp Cys
                  50                  55                  60

 tcg aaa aat gtc cag aga aaa cag aga cac tgg gaa aag ata gtt gca      300
 Ser Lys Asn Val Gln Arg Lys Gln Arg His Trp Glu Lys Ile Val Ala
              65                  70                  75

 gca aag aag agc aaa aga aag caa gaa aaa gaa cga aga aaa gcc aat      348
 Ala Lys Lys Ser Lys Arg Lys Gln Glu Lys Glu Arg Arg Lys Ala Asn
          80                  85                  90

 cgt gca gaa aat cca ggc att tgc ccc cag cac agc aaa cgt ttc ctg      396
 Arg Ala Glu Asn Pro Gly Ile Cys Pro Gln His Ser Lys Arg Phe Leu
      95                 100                 105

 aga gct cta acc aaa gac aaa ctt ttg gaa gcc aaa cac tca gga cca      444
 Arg Ala Leu Thr Lys Asp Lys Leu Leu Glu Ala Lys His Ser Gly Pro
 110                 115                 120                 125

 aga cta tgt atc gat ttg agt atg acc cac tac atg tca aag aag gaa      492
 Arg Leu Cys Ile Asp Leu Ser Met Thr His Tyr Met Ser Lys Lys Glu
                 130                 135                 140

 tta agt aga ctg gct gga cag att cga agg ttg tat ggt tca aac aaa      540
 Leu Ser Arg Leu Ala Gly Gln Ile Arg Arg Leu Tyr Gly Ser Asn Lys
             145                 150                 155

 aaa gct gac agg cca ttt tgg atc tgc ctc act gga ttc aca aca gac      588
 Lys Ala Asp Arg Pro Phe Trp Ile Cys Leu Thr Gly Phe Thr Thr Asp
         160                 165                 170

 agt ccc ctt tat gaa gag tgt gtg agg atg aat gat gga ttt tct agt      636
 Ser Pro Leu Tyr Glu Glu Cys Val Arg Met Asn Asp Gly Phe Ser Ser
     175                 180                 185

 tac ctg tta gac ata aca gaa gaa gac tgc ttt agt tta ttt ccc ttg      684
 Tyr Leu Leu Asp Ile Thr Glu Glu Asp Cys Phe Ser Leu Phe Pro Leu
 190                 195                 200                 205

 gaa acc ctt gtg tac ctg act cct gac tca gaa cac gct ctt gaa gat      732
 Glu Thr Leu Val Tyr Leu Thr Pro Asp Ser Glu His Ala Leu Glu Asp
                 210                 215                 220

 gtt gat cta aac aaa gtt tac atc ctc ggt ggg ctt gtg gat gaa agc      780
 Val Asp Leu Asn Lys Val Tyr Ile Leu Gly Gly Leu Val Asp Glu Ser
             225                 230                 235

 att cag aag aag gtg aca ttt caa aag gcc cgg gaa tac tct gtc aag      828
 Ile Gln Lys Lys Val Thr Phe Gln Lys Ala Arg Glu Tyr Ser Val Lys
         240                 245                 250

 acc gca cgc ttg cca atc cag gaa tac atg gtc aga aac cag aat ggg      876
 Thr Ala Arg Leu Pro Ile Gln Glu Tyr Met Val Arg Asn Gln Asn Gly
     255                 260                 265

 aaa aac tat cat tca gag ata ctg gcc atc aat caa gtg ttt gat atc      924
 Lys Asn Tyr His Ser Glu Ile Leu Ala Ile Asn Gln Val Phe Asp Ile
 270                 275                 280                 285

 ctg tcc act tac tta gag act cac aac tgg cct gaa gca ttg aag aaa      972
 Leu Ser Thr Tyr Leu Glu Thr His Asn Trp Pro Glu Ala Leu Lys Lys
                 290                 295                 300

 gga gtt tct tca gga aaa ggc tat att ctt cgg aac tca gtg gaa tga     1020
 Gly Val Ser Ser Gly Lys Gly Tyr Ile Leu Arg Asn Ser Val Glu 
             305                 310                 315

 tgggcctaag attgcagctg cg                                            1042




      <210> 176
      <211> 1569
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (457)..(1359)

      <400> 176
 atgatctctg atcaaggaca gttaactcac cacctgactt ctgcaaacac gcttaacaaa     60

 gacttttttt gtggaggacg attggggcct gtgcagacct ggtatcagcc accagcattt    120

 cagtgcaagg gtttagcggc ggcggacgga gaggggcctc tgctacccaa gaagcagaag    180

 cggccggcga cgcgtcgcag gctggtgcac tatctgaagg gccgggaggt aggagcgcgg    240

 ggcccagccg ggctccaggg cttcgagggc gagctgcggg gctacgccgt ccagaggctg    300

 cccgagctgc tgacggagcg ccagctggac ctgggcaccc tcaacaaggt gttcgcgtca    360

 cagtggctga acgccaggca ggtggtgtgc ggcaccaagt gtaatacgct gtttgtggtg    420

 gacgtgcagt caggccacat cacgcgcatc cccctc  atg cgg gac aag gag gcc     474
                                          Met Arg Asp Lys Glu Ala
                                            1               5

 ggg ctg gcc cag gcc cac cag ggc tgc ggc atc cat gcc atc gag ctg      522
 Gly Leu Ala Gln Ala His Gln Gly Cys Gly Ile His Ala Ile Glu Leu
              10                  15                  20

 aat ccc tcc aag acg ctt ctg gcc acc ggc ggc gaa aac ccc aac agc      570
 Asn Pro Ser Lys Thr Leu Leu Ala Thr Gly Gly Glu Asn Pro Asn Ser
          25                  30                  35

 ctg gcc atc tac cag ctg ccc acc ctg gac ccc ctg tgc ctg ggc gac      618
 Leu Ala Ile Tyr Gln Leu Pro Thr Leu Asp Pro Leu Cys Leu Gly Asp
      40                  45                  50

 cgc cat ggc cac aag gac tgg atc ttc gca gtc gcc tgg ctg agt gac      666
 Arg His Gly His Lys Asp Trp Ile Phe Ala Val Ala Trp Leu Ser Asp
  55                  60                  65                  70

 acc gta gct gtg agc ggc tcc cgc gac ggc acc gtg gct ctg tgg cgg      714
 Thr Val Ala Val Ser Gly Ser Arg Asp Gly Thr Val Ala Leu Trp Arg
                  75                  80                  85

 atg gac cca gac atg ttt aat ggc agc att gcc tgg cac agc gag gtg      762
 Met Asp Pro Asp Met Phe Asn Gly Ser Ile Ala Trp His Ser Glu Val
              90                  95                 100

 ggt ctc cca gta tat gcc cac atc cgt ccg agg gat gtg gag gcc atc      810
 Gly Leu Pro Val Tyr Ala His Ile Arg Pro Arg Asp Val Glu Ala Ile
         105                 110                 115

 ccc agg gcc agc acc aac ccc agc aac cgc aag gta cgg gcc ctg gcc      858
 Pro Arg Ala Ser Thr Asn Pro Ser Asn Arg Lys Val Arg Ala Leu Ala
     120                 125                 130

 ttc agc ggc aag aac cag gag ctg gga gcg gtg tcc ttg gac ggc tac      906
 Phe Ser Gly Lys Asn Gln Glu Leu Gly Ala Val Ser Leu Asp Gly Tyr
 135                 140                 145                 150

 ttc cac tgt gat gag ttg tcc ctg tac gct gtg ggc tct cag tcc cac      954
 Phe His Cys Asp Glu Leu Ser Leu Tyr Ala Val Gly Ser Gln Ser His
                 155                 160                 165

 gtc tcc ttc ctg gat ccg cgc cag cgc cag cag aac atc cgg ccc ctg     1002
 Val Ser Phe Leu Asp Pro Arg Gln Arg Gln Gln Asn Ile Arg Pro Leu
             170                 175                 180

 tgc tct cga gag ggt ggc aca ggc gtg cgg tcg ctg agc ttc tac cag     1050
 Cys Ser Arg Glu Gly Gly Thr Gly Val Arg Ser Leu Ser Phe Tyr Gln
         185                 190                 195

 cac atc atc act gtg ggc acc ggc cat ggt tcc ctg ctc ttc tat gac     1098
 His Ile Ile Thr Val Gly Thr Gly His Gly Ser Leu Leu Phe Tyr Asp
     200                 205                 210

 atc cgc gcc cag aag ttc ctg gag gag agg gcc tct tcc agc ctg gac     1146
 Ile Arg Ala Gln Lys Phe Leu Glu Glu Arg Ala Ser Ser Ser Leu Asp
 215                 220                 225                 230

 tcc atg ccg ggg ccc gca ggg agg aag ctc aag ctt gcc tgc ggc aga     1194
 Ser Met Pro Gly Pro Ala Gly Arg Lys Leu Lys Leu Ala Cys Gly Arg
                 235                 240                 245

 ggc tgg ctc aac caa gat gac gtc tgg gtg aac tac ttt ggt ggc atg     1242
 Gly Trp Leu Asn Gln Asp Asp Val Trp Val Asn Tyr Phe Gly Gly Met
             250                 255                 260

 gga gag ttc ccc aat gcg ctc tac acc cac tgc tac aac tgg ccg gag     1290
 Gly Glu Phe Pro Asn Ala Leu Tyr Thr His Cys Tyr Asn Trp Pro Glu
         265                 270                 275

 atg aag ctc ttt gtg gct ggg ggg cct ctc cct tca ggc ctc cat ggg     1338
 Met Lys Leu Phe Val Ala Gly Gly Pro Leu Pro Ser Gly Leu His Gly
     280                 285                 290

 aac tac gca ggc ctc tgg agt ta aggatggacg ccttgttctc aaagtgcaca     1391
 Asn Tyr Ala Gly Leu Trp Ser 
 295                 300

 ggtggaacca gtccaactta cgtgtgctta atgtattagg cagagaaaga aagagagaga   1451

 gcgggagcga gagagcacaa gtggtccttt cggcagtcaa aactttggct ttaaaactct   1511

 cattcacgtt tcccaacagc agtatatttt tgccttctca ttcacagagt tttggcta     1569




      <210> 177
      <211> 1809
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (79)..(1695)

      <400> 177
 cggcacgagg gggggttgtc ggtctataag cctcgcccgt tccgctccct ggggcttccc     60

 cgagcgccgt cggtggtc  atg gct gcc cca gcc tcc cgg cag gtc cga cgc     111
                      Met Ala Ala Pro Ala Ser Arg Gln Val Arg Arg
                        1               5                  10

 aga gcc cgg gca gcg ccg cgg ccc cgc tcg gcc gag gac tgg tgg tgg      159
 Arg Ala Arg Ala Ala Pro Arg Pro Arg Ser Ala Glu Asp Trp Trp Trp
              15                  20                  25

 gac cgg ctg gcg ccg agg ggc tcg ggg tac cac ctg ctg cag tcc gac      207
 Asp Arg Leu Ala Pro Arg Gly Ser Gly Tyr His Leu Leu Gln Ser Asp
          30                  35                  40

 agc atg ctg ctg gtg ctg tcc gaa ccc ggc ccc gcc cgg ccc cgc gca      255
 Ser Met Leu Leu Val Leu Ser Glu Pro Gly Pro Ala Arg Pro Arg Ala
      45                  50                  55

 cag cgg cgc gct tcc cgc cgc act ccc cgg cag ccg ccc cgg ggc ccc      303
 Gln Arg Arg Ala Ser Arg Arg Thr Pro Arg Gln Pro Pro Arg Gly Pro
  60                  65                  70                  75

 agc gcc gcg gcc aag ccc aag gcc ggg ctc agg tcc gag gcg gcg gcc      351
 Ser Ala Ala Ala Lys Pro Lys Ala Gly Leu Arg Ser Glu Ala Ala Ala
                  80                  85                  90

 gcg ccc gca ccc gca ccg gca ccc acg ccc acg ccc gag gaa ggg ccc      399
 Ala Pro Ala Pro Ala Pro Ala Pro Thr Pro Thr Pro Glu Glu Gly Pro
              95                 100                 105

 gac gcg ggc tgg gga gac cgc att ccc ttg gaa atc ctg gtg cag att      447
 Asp Ala Gly Trp Gly Asp Arg Ile Pro Leu Glu Ile Leu Val Gln Ile
         110                 115                 120

 ttc ggg ttg ttg gtg gcg gcg gac ggc ccc atg ccc ttc ctg ggc agg      495
 Phe Gly Leu Leu Val Ala Ala Asp Gly Pro Met Pro Phe Leu Gly Arg
     125                 130                 135

 gct gcg cgc gtg tgc cgc cgc tgg cag gag gcc gct tcc caa ccc gcg      543
 Ala Ala Arg Val Cys Arg Arg Trp Gln Glu Ala Ala Ser Gln Pro Ala
 140                 145                 150                 155

 ctc tgg cac acc gtg acc ctg tcg tcc ccg ctg gtc ggc cgg cct gcc      591
 Leu Trp His Thr Val Thr Leu Ser Ser Pro Leu Val Gly Arg Pro Ala
                 160                 165                 170

 aag ggc ggg gtc aag gcg gag aag aag ctc ctt gct tcc ctg gag tgg      639
 Lys Gly Gly Val Lys Ala Glu Lys Lys Leu Leu Ala Ser Leu Glu Trp
             175                 180                 185

 ctt atg ccc aat cgg ttt tca cag ctc cag agg ctg acc ctc atc cac      687
 Leu Met Pro Asn Arg Phe Ser Gln Leu Gln Arg Leu Thr Leu Ile His
         190                 195                 200

 tgg aag tct cag gta cac ccc gtg ttg aag ctg gta ggt gag tgc tgt      735
 Trp Lys Ser Gln Val His Pro Val Leu Lys Leu Val Gly Glu Cys Cys
     205                 210                 215

 cct cgg ctc act ttc ctc aag ctc tcc ggc tgc cac ggt gtg act gct      783
 Pro Arg Leu Thr Phe Leu Lys Leu Ser Gly Cys His Gly Val Thr Ala
 220                 225                 230                 235

 gac gct ctg gtc atg cta gcc aaa gcc tgc tgc cag ctc cat agc ctg      831
 Asp Ala Leu Val Met Leu Ala Lys Ala Cys Cys Gln Leu His Ser Leu
                 240                 245                 250

 gac cta cag cac tcc atg gtg gag tcc aca gct gtg gtg agc ttc ttg      879
 Asp Leu Gln His Ser Met Val Glu Ser Thr Ala Val Val Ser Phe Leu
             255                 260                 265

 gag gag gca ggg tcc cga atg cgc aag ttg tgg ctg acc tac agc tcc      927
 Glu Glu Ala Gly Ser Arg Met Arg Lys Leu Trp Leu Thr Tyr Ser Ser
         270                 275                 280

 cag acg aca gcc atc ctg ggc gca ctg ctg ggc agc tgc tgc ccc cag      975
 Gln Thr Thr Ala Ile Leu Gly Ala Leu Leu Gly Ser Cys Cys Pro Gln
     285                 290                 295

 ctc cag gtc ctg gag gtg agc acc ggc atc aac cgt aat agc att ccc     1023
 Leu Gln Val Leu Glu Val Ser Thr Gly Ile Asn Arg Asn Ser Ile Pro
 300                 305                 310                 315

 ctt cag ctg cct gtc gag gct ctg cag aaa ggc tgc cct cag ctc cag     1071
 Leu Gln Leu Pro Val Glu Ala Leu Gln Lys Gly Cys Pro Gln Leu Gln
                 320                 325                 330

 gtg ctg cgg ctg ttg aac ctg atg tgg ctg ccc aag cct ccg gga cga     1119
 Val Leu Arg Leu Leu Asn Leu Met Trp Leu Pro Lys Pro Pro Gly Arg
             335                 340                 345

 ggg gtg gct ccc gga cca ggc ttc cct agc cta gag gag ctc tgc ctg     1167
 Gly Val Ala Pro Gly Pro Gly Phe Pro Ser Leu Glu Glu Leu Cys Leu
         350                 355                 360

 gcg agc tca acc tgc aac ttt gtg agc aac gag gtc ctg ggc cgc cta     1215
 Ala Ser Ser Thr Cys Asn Phe Val Ser Asn Glu Val Leu Gly Arg Leu
     365                 370                 375

 ctc cac ggc tct ccc aac ctg cgc tta ctg gat ctt cgt ggc tgt gcg     1263
 Leu His Gly Ser Pro Asn Leu Arg Leu Leu Asp Leu Arg Gly Cys Ala
 380                 385                 390                 395

 cgc atc acg ccg gct ggc ctt cag gat ctg cca tgt cgg gag ctg gag     1311
 Arg Ile Thr Pro Ala Gly Leu Gln Asp Leu Pro Cys Arg Glu Leu Glu
                 400                 405                 410

 cag ctt cat ctg ggc ctg tat ggc acg tca gac cgg ctg act cta gcc     1359
 Gln Leu His Leu Gly Leu Tyr Gly Thr Ser Asp Arg Leu Thr Leu Ala
             415                 420                 425

 aag gag ggc agc ccc ttt ttg acc cag aag tgg tgc cat aca ctg cga     1407
 Lys Glu Gly Ser Pro Phe Leu Thr Gln Lys Trp Cys His Thr Leu Arg
         430                 435                 440

 gaa ctg gac ttg agt ggc cag ggg ttc agt gag aag gac ctg gag cag     1455
 Glu Leu Asp Leu Ser Gly Gln Gly Phe Ser Glu Lys Asp Leu Glu Gln
     445                 450                 455

 gcc ctg gct gcc ttc tta agc acc cct ggg ggc tca cac cca gcc ctg     1503
 Ala Leu Ala Ala Phe Leu Ser Thr Pro Gly Gly Ser His Pro Ala Leu
 460                 465                 470                 475

 tgc tct ctt aac ctc agg ggc acc cgg gtc aca cca agc act gtc agc     1551
 Cys Ser Leu Asn Leu Arg Gly Thr Arg Val Thr Pro Ser Thr Val Ser
                 480                 485                 490

 tct gtg atc agc agc tgc ccg ggc ctg ctc tac ctc aac ctg gag tcc     1599
 Ser Val Ile Ser Ser Cys Pro Gly Leu Leu Tyr Leu Asn Leu Glu Ser
             495                 500                 505

 tgc cgc tgc ctt ccc cgg ggt ctg aag cgg gcc tac cgg ggc ctg gag     1647
 Cys Arg Cys Leu Pro Arg Gly Leu Lys Arg Ala Tyr Arg Gly Leu Glu
         510                 515                 520

 gaa gtc cag tgg tgt ctg gag cag ctg ctc acc agc ccc tca ccc agc     1695
 Glu Val Gln Trp Cys Leu Glu Gln Leu Leu Thr Ser Pro Ser Pro Ser 
     525                 530                 535

 taggcagcca cagacctggg acacctcagc cagcttgccc accctccacc tttgcccaat   1755

 ttcagatatt tgagcatttt gttaaaataa aacattttta ggaaaaaaaa aaaa         1809




      <210> 178
      <211> 1401
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (106)..(822)

      <400> 178
 ggactaagcc ggggagcgca tcccggctac tgcgggtcct gggtcttcac ctgcggagcc     60

 ttacggcagc tgagcggtgg gagggacctg agccgcggcg ctagg    atg gga aac     114
                                                      Met Gly Asn
                                                        1

 agt gcg ctc cgc gct cat gtg gaa acg gcg cag aaa act ggt gtc ttt      162
 Ser Ala Leu Arg Ala His Val Glu Thr Ala Gln Lys Thr Gly Val Phe
       5                  10                  15

 cag ctt aag gac cga ggg ctg acc gag ttc ccc gca gac ttg cag aag      210
 Gln Leu Lys Asp Arg Gly Leu Thr Glu Phe Pro Ala Asp Leu Gln Lys
  20                  25                  30                  35

 ctg acg agc aat ctc agg acc atc gac ttg tcc aac aac aag atc gaa      258
 Leu Thr Ser Asn Leu Arg Thr Ile Asp Leu Ser Asn Asn Lys Ile Glu
                  40                  45                  50

 agc cta ccg cct ttg ctg ata gga aag ttc act ctg ctg aag agc ctc      306
 Ser Leu Pro Pro Leu Leu Ile Gly Lys Phe Thr Leu Leu Lys Ser Leu
              55                  60                  65

 tcc ctg aac aac aac aaa ctg act gtt ctg cct gat gag ata tgc aat      354
 Ser Leu Asn Asn Asn Lys Leu Thr Val Leu Pro Asp Glu Ile Cys Asn
          70                  75                  80

 ctg aaa aaa cta gag acg cta agc cta aac aac aat cac ctt aga gag      402
 Leu Lys Lys Leu Glu Thr Leu Ser Leu Asn Asn Asn His Leu Arg Glu
      85                  90                  95

 ctg ccg tct acc ttt ggg caa ctc tct gcc ctc aag acc ctg agc ctc      450
 Leu Pro Ser Thr Phe Gly Gln Leu Ser Ala Leu Lys Thr Leu Ser Leu
 100                 105                 110                 115

 tct ggg aac caa ctg gga gca tta cct ccc caa ctt tgt agc cta cgg      498
 Ser Gly Asn Gln Leu Gly Ala Leu Pro Pro Gln Leu Cys Ser Leu Arg
                 120                 125                 130

 cac ctg gat gtg atg gat ctc tct aag aac cag att cga agt ata cct      546
 His Leu Asp Val Met Asp Leu Ser Lys Asn Gln Ile Arg Ser Ile Pro
             135                 140                 145

 gac tca gtg gga gag ctg caa gtc atc gaa ctc aac ctc aac cag aat      594
 Asp Ser Val Gly Glu Leu Gln Val Ile Glu Leu Asn Leu Asn Gln Asn
         150                 155                 160

 cag ata tct cag atc tca gtg aag ata tct tgc tgt cca cgc ctt aaa      642
 Gln Ile Ser Gln Ile Ser Val Lys Ile Ser Cys Cys Pro Arg Leu Lys
     165                 170                 175

 att ctt cgc ctg gaa gag aat tgt ctt gag ctc agc atg ctt ccc cag      690
 Ile Leu Arg Leu Glu Glu Asn Cys Leu Glu Leu Ser Met Leu Pro Gln
 180                 185                 190                 195

 agc atc ctc agt gat tcc cag atc tgt ctg ctt gct gtg gaa ggc aat      738
 Ser Ile Leu Ser Asp Ser Gln Ile Cys Leu Leu Ala Val Glu Gly Asn
                 200                 205                 210

 ctt ttt gaa ata aag aaa ctt cga gaa ctg gaa ggc tat gat aag tac      786
 Leu Phe Glu Ile Lys Lys Leu Arg Glu Leu Glu Gly Tyr Asp Lys Tyr
             215                 220                 225

 atg gag agg ttc aca gcc acc aag aag aag ttt gcg tgaa gttctccagg      836
 Met Glu Arg Phe Thr Ala Thr Lys Lys Lys Phe Ala 
         230                 235

 actatggaaa ccttacagga tactgactta gaacctctgt tggaatgtgg ctgagtcaaa    896

 gcctcctgtt gttgttaggg gtatctacag taaggagatg atacttcagg agattatatt    956

 tcactcaatg atcttttctc atttcagggc tcttctcaaa taagctaaaa gaaaaaggat   1016

 caggagacag gaaaagtctt ccgttttgag tcatgagtag ggcaatagac aaggttctct   1076

 tcaaaaccat cattagtttg gctttaagaa accagtagct agctgctatt tatatggtga   1136

 gggggtgctg cctggtaaca gaatagctcc acaccacagc ttgagatttt gtttagtttc   1196

 actgtgtgag ctttcataaa gtctgttgcc attccatctc tgtgttaaca cttcatattt   1256

 ttatgaaatt cagataattt gtgagaggct ggcatggatc taaggattta ttatttttat   1316

 tctagtccat cagttcagtc gcagttttta tactaggact ttaggatgta cataaatgtg   1376

 tgactgtttg tcttgattaa aagtg                                         1401




      <210> 179
      <211> 1430
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (108)..(650)

      <400> 179
 ggcacgaggg tgggcactgg aaacgtgtgg ccagaagggg aaacgctcgg gcctttggtg     60

 ggggccagcc tggggtgggg tcggccaggg tcagctgcct ttccttc  atg ctg ggg     116
                                                      Met Leu Gly
                                                        1

 agg aga tgt tgt gtg cat gtg aga aag cat ttg ata gca tgc caa aag      164
 Arg Arg Cys Cys Val His Val Arg Lys His Leu Ile Ala Cys Gln Lys
       5                  10                  15

 ttt cct cca tta tgt gcg tgt caa gtg ttt gac cag gtc aga act ctt      212
 Phe Pro Pro Leu Cys Ala Cys Gln Val Phe Asp Gln Val Arg Thr Leu
  20                  25                  30                  35

 gtt cta tgc gaa tgt gct cac gca gac aga agc gga ggg gct ccg tcg      260
 Val Leu Cys Glu Cys Ala His Ala Asp Arg Ser Gly Gly Ala Pro Ser
                  40                  45                  50

 ctc tgc cct cac gcc gct gaa ccg cga ggg tct ccc gct cct cag gct      308
 Leu Cys Pro His Ala Ala Glu Pro Arg Gly Ser Pro Ala Pro Gln Ala
              55                  60                  65

 tgc ggc tcg gcc gcg aag tgt gtc agg tgt gca tcc tgg gtg ctc ctt      356
 Cys Gly Ser Ala Ala Lys Cys Val Arg Cys Ala Ser Trp Val Leu Leu
          70                  75                  80

 tgt gct ctg tcc tac ggt gac aca ggc ggc gtg ggg tta gac agg tac      404
 Cys Ala Leu Ser Tyr Gly Asp Thr Gly Gly Val Gly Leu Asp Arg Tyr
      85                  90                  95

 cgg tca tac tac ggt gac aca ggc ggc gtg cgg tta gac agg tac cgg      452
 Arg Ser Tyr Tyr Gly Asp Thr Gly Gly Val Arg Leu Asp Arg Tyr Arg
 100                 105                 110                 115

 tca gat tac ggt ggc aca ggc ggc gtg ggg tta gac agg tac cgg tca      500
 Ser Asp Tyr Gly Gly Thr Gly Gly Val Gly Leu Asp Arg Tyr Arg Ser
                 120                 125                 130

 gat tac ggt gac aca ggc ggc gtg ggg tta gac agg tac cgg tca gat      548
 Asp Tyr Gly Asp Thr Gly Gly Val Gly Leu Asp Arg Tyr Arg Ser Asp
             135                 140                 145

 tac ggt ggc aca ggc tgc gtg ggg tta gac agg tac cgg tca gat tac      596
 Tyr Gly Gly Thr Gly Cys Val Gly Leu Asp Arg Tyr Arg Ser Asp Tyr
         150                 155                 160

 ggt ggc aca ggc ggc gtg ggg tta gac agg tac tgg tca gat gca cgg      644
 Gly Gly Thr Gly Gly Val Gly Leu Asp Arg Tyr Trp Ser Asp Ala Arg
     165                 170                 175

 gct ccc taaacccctg ctgtggcttc ggcagtaaag acaggacgca cccatgtcac       700
 Ala Pro 
 180

 aagaggagca caggcagggg tgttggtgtt ggggcagccc tcagggtctc cagaccccag    760

 ccccactcac acagcagcct aggaaggaag ggcagagtcc caggtgtcag ctggtgggtc    820

 tcccaggagc tgcccctccc tggaagtcac aggacaggaa tgacagatca gggaactgca    880

 ggaagctgcc acctctgggg tcagaatatg cccagcctgc gggggctctc tatcggggtc    940

 ttcgagagcc agacagcctg ccttgtgctg catacctggc tttgctctgt gcagaaccca   1000

 gcacacgtga ttttgtgtga catgccagca gcctggctcc caggacagga ggcctgccct   1060

 gggggagggg ctgcaggagg agggggggca ggcacccatg agtctgtcca gccttgtcac   1120

 agatgcatcg cccagcctgc ggtcctgatt tcagctcacc tcagagtaaa tcagaataaa   1180

 ctgcacccag actttcacga atgcatgttg acgctttcag ttcacccctt tctttgctaa   1240

 ctttcttcct attttcttct aatgcgagag cttattaatt ccatatttat cattttgaat   1300

 aacttttctc ctttttagta acaaaatgta cttcactctt agtaaaatgt atttactatt   1360

 ttagtaacaa aaatatactt gcctaatcat gtttaaaata tagtgatgtg aaaaattcaa   1420

 aaaaaaaaaa                                                          1430




      <210> 180
      <211> 2783
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (418)..(2268)

      <400> 180
 ccgtgccgga attgccgcga cgacccacgc gtacgacgac atccgaaacc tcgagctgag     60

 tctgagggtt ggccccactc agatgcacca gcctcttgga ctgtatattt acacattcac    120

 acaccatcac cctttctaac ttctgggact ctttgcgcaa ctgctaggat ctctcaagtg    180

 catgtggcaa cacagcccag ctccgggcgg aaaccagcag ggctctggag gggctcggag    240

 accaggcgag ctgtcaaggc tgcggcgggg accagagagg agcctggcgg gggtggctgg    300

 gtggctgggg gaatcccccc aacttcccat cgcaggcgca gctctctcgg ccgcctattt    360

 cctccgaaac ccgcgctgcg gagcagccca gtgcatagag ttcaacactt ccccttg       417                                                                 
 atg tgg aaa gta aag gag cct cac tac cac ctt ttt ttc ttt gcg ttt      465
 Met Trp Lys Val Lys Glu Pro His Tyr His Leu Phe Phe Phe Ala Phe
   1               5                  10                  15

 tct tac tgc tgg tcc tgg gag cct ttt cct tcg gag cag cag ccc tgt      513
 Ser Tyr Cys Trp Ser Trp Glu Pro Phe Pro Ser Glu Gln Gln Pro Cys
              20                  25                  30

 ccg gca tct gtc ttg agc tcc cag caa gga aag tcc atc agc ttg ata      561
 Pro Ala Ser Val Leu Ser Ser Gln Gln Gly Lys Ser Ile Ser Leu Ile
          35                  40                  45

 atg gag gag aac aat gac tcc acg gag aac ccc caa caa ggc caa ggg      609
 Met Glu Glu Asn Asn Asp Ser Thr Glu Asn Pro Gln Gln Gly Gln Gly
      50                  55                  60

 cgg cag aat gcc atc aag tgt ggg tgg ctg agg aag caa gga ggc ttt      657
 Arg Gln Asn Ala Ile Lys Cys Gly Trp Leu Arg Lys Gln Gly Gly Phe
  65                  70                  75                  80

 gtc aag act tgg cat act cgc tgg ttt gtg ctc aag ggg gat cag ctc      705
 Val Lys Thr Trp His Thr Arg Trp Phe Val Leu Lys Gly Asp Gln Leu
                  85                  90                  95

 tat tat ttc aaa gat gaa gat gaa acc aag ccc ttg ggt act att ttt      753
 Tyr Tyr Phe Lys Asp Glu Asp Glu Thr Lys Pro Leu Gly Thr Ile Phe
             100                 105                 110

 ctg cct gga aat aaa gtt tct gag cat ccc tgc aat gaa gag aac cca      801
 Leu Pro Gly Asn Lys Val Ser Glu His Pro Cys Asn Glu Glu Asn Pro
         115                 120                 125

 ggg aag ttc ctt ttt gaa gta gtt cca gga ggc gat cga gat cgg atg      849
 Gly Lys Phe Leu Phe Glu Val Val Pro Gly Gly Asp Arg Asp Arg Met
     130                 135                 140

 aca gca aat cat gaa agc tac ctc ctc atg gca agc acc cag aat gat      897
 Thr Ala Asn His Glu Ser Tyr Leu Leu Met Ala Ser Thr Gln Asn Asp
 145                 150                 155                 160

 atg gaa gac tgg gtg aag tca atc cgc cga gtc ata tgg gga cct ttc      945
 Met Glu Asp Trp Val Lys Ser Ile Arg Arg Val Ile Trp Gly Pro Phe
                 165                 170                 175

 gga gga ggc act gtg gtg gtc cag cag ttg atg tca gtg atg att agc      993
 Gly Gly Gly Thr Val Val Val Gln Gln Leu Met Ser Val Met Ile Ser
             180                 185                 190

 aaa cat gat tgc ctc ttt ccc aaa gat gca gaa cta caa agc aag ccc     1041
 Lys His Asp Cys Leu Phe Pro Lys Asp Ala Glu Leu Gln Ser Lys Pro
         195                 200                 205

 caa gat gga gtg agc aac aac aat gaa att cag aag aaa gcc acc atg     1089
 Gln Asp Gly Val Ser Asn Asn Asn Glu Ile Gln Lys Lys Ala Thr Met
     210                 215                 220

 ggg cag tta cag aac aag gag aac aat aac acc aag gac agc cct agt     1137
 Gly Gln Leu Gln Asn Lys Glu Asn Asn Asn Thr Lys Asp Ser Pro Ser
 225                 230                 235                 240

 agg cag tgc tcc tgg gac aag tct gag tca ccc cag aga agc agc atg     1185
 Arg Gln Cys Ser Trp Asp Lys Ser Glu Ser Pro Gln Arg Ser Ser Met
                 245                 250                 255

 aac aat gga tcc ccc aca gct cta tca ggc agc aaa acc aac agc cca     1233
 Asn Asn Gly Ser Pro Thr Ala Leu Ser Gly Ser Lys Thr Asn Ser Pro
             260                 265                 270

 aag aac agt gtt cac aag cta gat gtg tct aga agc ccc cct ctc atg     1281
 Lys Asn Ser Val His Lys Leu Asp Val Ser Arg Ser Pro Pro Leu Met
         275                 280                 285

 gtc aaa aag aac cca gcc ttt aat aag ggt agt ggg ata gtt acc aat     1329
 Val Lys Lys Asn Pro Ala Phe Asn Lys Gly Ser Gly Ile Val Thr Asn
     290                 295                 300

 ggg tcc ttc agc agc agt aat gca gaa ggt ctt gag aaa acc caa acc     1377
 Gly Ser Phe Ser Ser Ser Asn Ala Glu Gly Leu Glu Lys Thr Gln Thr
 305                 310                 315                 320

 acc ccc aat ggg agc cta cag gcc aga agg agc tct tca ctg aag gta     1425
 Thr Pro Asn Gly Ser Leu Gln Ala Arg Arg Ser Ser Ser Leu Lys Val
                 325                 330                 335

 tct ggt acc aaa atg ggc acg cac agt gta cag aat gga acg gtg cgc     1473
 Ser Gly Thr Lys Met Gly Thr His Ser Val Gln Asn Gly Thr Val Arg
             340                 345                 350

 atg ggc att ttg aac agc gac aca ctc ggg aac ccc aca aat gtt cga     1521
 Met Gly Ile Leu Asn Ser Asp Thr Leu Gly Asn Pro Thr Asn Val Arg
         355                 360                 365

 aac atg agc tgg ctg cca aat ggc tat gtg acc ctg agg gat aac aag     1569
 Asn Met Ser Trp Leu Pro Asn Gly Tyr Val Thr Leu Arg Asp Asn Lys
     370                 375                 380

 cag aaa gaa caa gct gga gag tta ggc cag cac aac aga ctg tcc acc     1617
 Gln Lys Glu Gln Ala Gly Glu Leu Gly Gln His Asn Arg Leu Ser Thr
 385                 390                 395                 400

 tat gat aat gtc cat caa cag ttc tcc atg atg aac ctt gat gac aag     1665
 Tyr Asp Asn Val His Gln Gln Phe Ser Met Met Asn Leu Asp Asp Lys
                 405                 410                 415

 cag agc att gac agt gct acc tgg tcc act tcc tcc tgt gaa atc tcc     1713
 Gln Ser Ile Asp Ser Ala Thr Trp Ser Thr Ser Ser Cys Glu Ile Ser
             420                 425                 430

 ctc cct gag aac tcc aac tcc tgt cgc tct tct acc acc acc tgc cca     1761
 Leu Pro Glu Asn Ser Asn Ser Cys Arg Ser Ser Thr Thr Thr Cys Pro
         435                 440                 445

 gag caa gac ttt ttt ggg ggg aac ttt gag gac cct gtt ttg gat ggg     1809
 Glu Gln Asp Phe Phe Gly Gly Asn Phe Glu Asp Pro Val Leu Asp Gly
     450                 455                 460

 ccc ccg cag gac gac ctt tcc cac ccc agg gac tat gaa agc aaa agt     1857
 Pro Pro Gln Asp Asp Leu Ser His Pro Arg Asp Tyr Glu Ser Lys Ser
 465                 470                 475                 480

 gac cac agg agt gtg gga ggt cga agt agt cgt gcc acc agt agc agt     1905
 Asp His Arg Ser Val Gly Gly Arg Ser Ser Arg Ala Thr Ser Ser Ser
                 485                 490                 495

 gac aac agt gag aca ttt gtg ggc aac agc agc agc aac cac agt gca     1953
 Asp Asn Ser Glu Thr Phe Val Gly Asn Ser Ser Ser Asn His Ser Ala
             500                 505                 510

 ctg cac agt tta gtt tcc agc ctg aaa cag gaa atg acc aaa cag aag     2001
 Leu His Ser Leu Val Ser Ser Leu Lys Gln Glu Met Thr Lys Gln Lys
         515                 520                 525

 ata gag tat gag tcc agg ata aag agc tta gaa cag cga aac ttg act     2049
 Ile Glu Tyr Glu Ser Arg Ile Lys Ser Leu Glu Gln Arg Asn Leu Thr
     530                 535                 540

 ttg gaa aca gaa atg atg agc ctc cat gat gaa ctg gat cag gag agg     2097
 Leu Glu Thr Glu Met Met Ser Leu His Asp Glu Leu Asp Gln Glu Arg
 545                 550                 555                 560

 aaa aag ttc aca atg ata gaa ata aaa atg cga aat gcc gag cga gca     2145
 Lys Lys Phe Thr Met Ile Glu Ile Lys Met Arg Asn Ala Glu Arg Ala
                 565                 570                 575

 aaa gaa gat gcc gag aaa aga aat gac atg cta cag aaa gaa atg gag     2193
 Lys Glu Asp Ala Glu Lys Arg Asn Asp Met Leu Gln Lys Glu Met Glu
             580                 585                 590

 cag ttt ttt tcc acg ttt gga gaa ctg aca gtg gaa ccc agg aga acc     2241
 Gln Phe Phe Ser Thr Phe Gly Glu Leu Thr Val Glu Pro Arg Arg Thr
         595                 600                 605

 gag aga gga aac aca ata tgg att cag tgagc ctgctttcgc ctgctgtctc     2293
 Glu Arg Gly Asn Thr Ile Trp Ile Gln 
     610                 615

 tgatggctct ggcaaggact ccagggattc tggtgggata tgacttagaa ccaggtggct   2353

 ggtcacctgg atgtacagaa gtctaactgg tgaaggaata tcatttacag acattaaaca   2413

 tccatatctg caatgtgtac caaagttata tcatgcccca taatgctact gtcaagtgtt   2473

 acaactggat atgtgtatat agagtagttt ttcaaaagta aactaaaaat gagaagcata   2533

 tttcaagaat tattttattg caagtcttgt atttaaatgt taaatcaata tgttgttgca   2593

 atttagcttg ctttcaagct tcaccccttg cacttaacat aagctatttt tggcattgtg   2653

 ttatcatcgg cttattttat agatcaatat ttttatttcc cttttttgct gaggaaatga   2713

 agataagcaa aaatataaat atatatataa atatatgagt tattaaaatc agaagaataa   2773

 aaaaaaaaaa                                                          2783




      <210> 181
      <211> 1256
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1203)

      <400> 181
  atg aaa gag aat ttc aaa cac agg cac gtg gtg gcg ttc att agc agt      48
  Met Lys Glu Asn Phe Lys His Arg His Val Val Ala Phe Ile Ser Ser
    1               5                  10                  15

 cag gaa gct cag gaa gat tca aga gag gaa gaa gac cga ctg gag tct       96
 Gln Glu Ala Gln Glu Asp Ser Arg Glu Glu Glu Asp Arg Leu Glu Ser
              20                  25                  30

 cgg ttt tac ttt ctt ttt ctc ttg gag ctg agc tat aag aca aca gga      144
 Arg Phe Tyr Phe Leu Phe Leu Leu Glu Leu Ser Tyr Lys Thr Thr Gly
          35                  40                  45

 ctg aac agg gag cca act gtt tct ttg aac agt aaa tca gga aca cca      192
 Leu Asn Arg Glu Pro Thr Val Ser Leu Asn Ser Lys Ser Gly Thr Pro
      50                  55                  60

 atg gac caa aat gaa cac agt cac tgg gga cca cat gca aag ggc caa      240
 Met Asp Gln Asn Glu His Ser His Trp Gly Pro His Ala Lys Gly Gln
  65                  70                  75                  80

 tgt gcc agc aga tct gag ctg aga atc atc ctg gtg ggc aaa aca gga      288
 Cys Ala Ser Arg Ser Glu Leu Arg Ile Ile Leu Val Gly Lys Thr Gly
                  85                  90                  95

 act ggc aaa agt gct gca ggg aac agc atc ctc agg aag caa gca ttt      336
 Thr Gly Lys Ser Ala Ala Gly Asn Ser Ile Leu Arg Lys Gln Ala Phe
             100                 105                 110

 gaa tcg aag ctg ggt tcc cag acc ttg act aag act tgc agc aaa agt      384
 Glu Ser Lys Leu Gly Ser Gln Thr Leu Thr Lys Thr Cys Ser Lys Ser
         115                 120                 125

 cag gga agc tgg gga aat aga gag att gtc att att gac aca cca gat      432
 Gln Gly Ser Trp Gly Asn Arg Glu Ile Val Ile Ile Asp Thr Pro Asp
     130                 135                 140

 atg ttt tct tgg aag gac cac tgt gaa gct ctg tac aaa gag gtg cag      480
 Met Phe Ser Trp Lys Asp His Cys Glu Ala Leu Tyr Lys Glu Val Gln
 145                 150                 155                 160

 agg tgc tac ttg ctc tct gca cca gga ccc cat gtg ctg ctc ctg gtg      528
 Arg Cys Tyr Leu Leu Ser Ala Pro Gly Pro His Val Leu Leu Leu Val
                 165                 170                 175

 act cag ctg ggc cgc tat acc tca cag gac cag cag gct gca cag agg      576
 Thr Gln Leu Gly Arg Tyr Thr Ser Gln Asp Gln Gln Ala Ala Gln Arg
             180                 185                 190

 gtg aag gag atc ttt gga gag gat gcc atg gga cac aca att gtc ctc      624
 Val Lys Glu Ile Phe Gly Glu Asp Ala Met Gly His Thr Ile Val Leu
         195                 200                 205

 ttt acc cac aag gaa gac ctc aat ggt ggc tcc ctg atg gat tac atg      672
 Phe Thr His Lys Glu Asp Leu Asn Gly Gly Ser Leu Met Asp Tyr Met
     210                 215                 220

 cac gac tca gat aac aaa gcc cta agc aag ctg gtg gca gca tgt ggt      720
 His Asp Ser Asp Asn Lys Ala Leu Ser Lys Leu Val Ala Ala Cys Gly
 225                 230                 235                 240

 ggg cga atc tgt gcc ttt aat aac cgt gct gaa ggg agc aat cag gat      768
 Gly Arg Ile Cys Ala Phe Asn Asn Arg Ala Glu Gly Ser Asn Gln Asp
                 245                 250                 255

 gac caa gtg aag gaa cta atg gac tgt att gag gat ctg ttg atg gag      816
 Asp Gln Val Lys Glu Leu Met Asp Cys Ile Glu Asp Leu Leu Met Glu
             260                 265                 270

 aaa aat ggt gat cac tat acc aat ggg ttg tac agc cta ata cag agg      864
 Lys Asn Gly Asp His Tyr Thr Asn Gly Leu Tyr Ser Leu Ile Gln Arg
         275                 280                 285

 tct aaa tgt gga cct gtg gga tca gat gaa aga gta aag gaa ttc aaa      912
 Ser Lys Cys Gly Pro Val Gly Ser Asp Glu Arg Val Lys Glu Phe Lys
     290                 295                 300

 cag agc ctt ata aag tac atg gaa act caa aga agt tac aca gcc ttg      960
 Gln Ser Leu Ile Lys Tyr Met Glu Thr Gln Arg Ser Tyr Thr Ala Leu
 305                 310                 315                 320

 gct gaa gca aac tgc cta aaa gga gcc tta atc aaa aca caa ctg tgt     1008
 Ala Glu Ala Asn Cys Leu Lys Gly Ala Leu Ile Lys Thr Gln Leu Cys
                 325                 330                 335

 gtt tta ttt tgt att cag ttg ttt ctc aga ttg ata att ctg tgg ctt     1056
 Val Leu Phe Cys Ile Gln Leu Phe Leu Arg Leu Ile Ile Leu Trp Leu
             340                 345                 350

 tgc ata ctg cac agc atg tgc aat ttg ttt tgt tgc tta ctc ttt agt     1104
 Cys Ile Leu His Ser Met Cys Asn Leu Phe Cys Cys Leu Leu Phe Ser
         355                 360                 365

 atg tgc aat tta ttc tgc agt ttg ctg ttt att ata ccc aaa aag tta     1152
 Met Cys Asn Leu Phe Cys Ser Leu Leu Phe Ile Ile Pro Lys Lys Leu
     370                 375                 380

 atg ata ttt ttg aga aca gtt att aga cta gaa cgc aag act cct agg     1200
 Met Ile Phe Leu Arg Thr Val Ile Arg Leu Glu Arg Lys Thr Pro Arg
 385                 390                 395                 400

 tta tagttacaga tcccagttat tatttactca ctatcattta gtgggtgaat cac      1256
 Leu 






      <210> 182
      <211> 2051
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1743)

      <400> 182
  atg tgg ggg cgc acg gcg cgg cgg cgc tgc ccg cgg gaa ctg cgg cgc      48
  Met Trp Gly Arg Thr Ala Arg Arg Arg Cys Pro Arg Glu Leu Arg Arg
    1               5                  10                  15

 ggc cgg gag gcg ctg ttg gtg ctc ctg gcg cta ctg gcg ttg gcc ggg       96
 Gly Arg Glu Ala Leu Leu Val Leu Leu Ala Leu Leu Ala Leu Ala Gly
              20                  25                  30

 ctg ggc tcg gtg ctg cgg gcg cag cgt ggg gcc ggg gcc ggg gct gcc      144
 Leu Gly Ser Val Leu Arg Ala Gln Arg Gly Ala Gly Ala Gly Ala Ala
          35                  40                  45

 gag ccg gga ccc ccg cgc acc ccg cgc ccc ggg cgg cgc gag ccg gtc      192
 Glu Pro Gly Pro Pro Arg Thr Pro Arg Pro Gly Arg Arg Glu Pro Val
      50                  55                  60

 atg ccg cgg ccg ccg gtg ccg gcg aac gcg ctg ggc gcg cgg ggc gag      240
 Met Pro Arg Pro Pro Val Pro Ala Asn Ala Leu Gly Ala Arg Gly Glu
  65                  70                  75                  80

 gcg gtg cgg ctg cag ctg cag ggc gag gag ctg cgg ctg cag gag gag      288
 Ala Val Arg Leu Gln Leu Gln Gly Glu Glu Leu Arg Leu Gln Glu Glu
                  85                  90                  95

 agc gtg cgg ctg cac cag att aac atc tac ctc agc gac cgc atc tca      336
 Ser Val Arg Leu His Gln Ile Asn Ile Tyr Leu Ser Asp Arg Ile Ser
             100                 105                 110

 ctg cac cgc cgc ctg ccc gag cgc tgg aac ccg ctg tgc aaa gag aag      384
 Leu His Arg Arg Leu Pro Glu Arg Trp Asn Pro Leu Cys Lys Glu Lys
         115                 120                 125

 aaa tat gat tat gat aat ttg ccc agg aca tct gtt atc ata gca ttt      432
 Lys Tyr Asp Tyr Asp Asn Leu Pro Arg Thr Ser Val Ile Ile Ala Phe
     130                 135                 140

 tat aat gaa gcc tgg tca act ctc ctt cgg aca gtt tac agt gtc ctt      480
 Tyr Asn Glu Ala Trp Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Leu
 145                 150                 155                 160

 gag aca tcc ccg gat atc ctg cta gaa gaa gtg atc ctt gta gat gac      528
 Glu Thr Ser Pro Asp Ile Leu Leu Glu Glu Val Ile Leu Val Asp Asp
                 165                 170                 175

 tac agt gat aga gag cac ctg aag gag cgc ttg gcc aat gag ctt tcg      576
 Tyr Ser Asp Arg Glu His Leu Lys Glu Arg Leu Ala Asn Glu Leu Ser
             180                 185                 190

 gga ctg ccc aag gtg cgc ctg atc cgc gcc aac aag aga gag ggc ctg      624
 Gly Leu Pro Lys Val Arg Leu Ile Arg Ala Asn Lys Arg Glu Gly Leu
         195                 200                 205

 gtg cga gcc cgg ctg ctg ggg gcg tct gcg gcg agg ggc gat gtt ctg      672
 Val Arg Ala Arg Leu Leu Gly Ala Ser Ala Ala Arg Gly Asp Val Leu
     210                 215                 220

 acc ttc ctg gac tgt cac tgt gag tgc cac gaa ggg tgg ctg gag ccg      720
 Thr Phe Leu Asp Cys His Cys Glu Cys His Glu Gly Trp Leu Glu Pro
 225                 230                 235                 240

 ctg ctg cag agg atc cat gaa gag gag tcg gca gtg gtg tgc ccg gtg      768
 Leu Leu Gln Arg Ile His Glu Glu Glu Ser Ala Val Val Cys Pro Val
                 245                 250                 255

 att gat gtg atc gac tgg aac acc ttc gaa tac ctg ggg aac tcc ggg      816
 Ile Asp Val Ile Asp Trp Asn Thr Phe Glu Tyr Leu Gly Asn Ser Gly
             260                 265                 270

 gag ccc cag atc ggc ggt ttc gac tgg agg ctg gtg ttc acg tgg cac      864
 Glu Pro Gln Ile Gly Gly Phe Asp Trp Arg Leu Val Phe Thr Trp His
         275                 280                 285

 aca gtt cct gag agg gag agg ata cgg atg caa tcc ccc gtc gat gtc      912
 Thr Val Pro Glu Arg Glu Arg Ile Arg Met Gln Ser Pro Val Asp Val
     290                 295                 300

 atc agg tct cca aca atg gct ggt ggg ctg ttt gct gtg agt aag aaa      960
 Ile Arg Ser Pro Thr Met Ala Gly Gly Leu Phe Ala Val Ser Lys Lys
 305                 310                 315                 320

 tat ttt gaa tat ctg ggg tct tat gat aca gga atg gaa gtt tgg gga     1008
 Tyr Phe Glu Tyr Leu Gly Ser Tyr Asp Thr Gly Met Glu Val Trp Gly
                 325                 330                 335

 gga gaa aac ctc gaa ttt tcc ttt agg atc tgg cag tgt ggt ggg gtt     1056
 Gly Glu Asn Leu Glu Phe Ser Phe Arg Ile Trp Gln Cys Gly Gly Val
             340                 345                 350

 ctg gaa aca cac cca tgt tcc cat gtt ggc cat gtt ttc ccc aag caa     1104
 Leu Glu Thr His Pro Cys Ser His Val Gly His Val Phe Pro Lys Gln
         355                 360                 365

 gct ccc tac tcc cgc aac aag gct ctg gcc aac agt gtt cgt gca gct     1152
 Ala Pro Tyr Ser Arg Asn Lys Ala Leu Ala Asn Ser Val Arg Ala Ala
     370                 375                 380

 gaa gta tgg atg gat gaa ttt aaa gag ctc tac tac cat cgc aac ccc     1200
 Glu Val Trp Met Asp Glu Phe Lys Glu Leu Tyr Tyr His Arg Asn Pro
 385                 390                 395                 400

 cgt gcc cgc ttg gaa cct ttt ggg gat gtg aca gag agg aag cag ctc     1248
 Arg Ala Arg Leu Glu Pro Phe Gly Asp Val Thr Glu Arg Lys Gln Leu
                 405                 410                 415

 cgg gac aag ctc cag tgt aaa gac ttc aag tgg ttc ttg gag act gtg     1296
 Arg Asp Lys Leu Gln Cys Lys Asp Phe Lys Trp Phe Leu Glu Thr Val
             420                 425                 430

 tat cca gaa ctg cat gtg cct gag gac agg cct ggc ttc ttc ggg atg     1344
 Tyr Pro Glu Leu His Val Pro Glu Asp Arg Pro Gly Phe Phe Gly Met
         435                 440                 445

 ctc cag aac aaa gga cta aca gac tac tgc ttt gac tat aac cct ccc     1392
 Leu Gln Asn Lys Gly Leu Thr Asp Tyr Cys Phe Asp Tyr Asn Pro Pro
     450                 455                 460

 gat gaa aac cag att gtg gga cac cag gtc att ctg tac ctc tgt cat     1440
 Asp Glu Asn Gln Ile Val Gly His Gln Val Ile Leu Tyr Leu Cys His
 465                 470                 475                 480

 ggg atg ggc cag aat cag ttt ttc gag tac acg tcc cag aaa gaa ata     1488
 Gly Met Gly Gln Asn Gln Phe Phe Glu Tyr Thr Ser Gln Lys Glu Ile
                 485                 490                 495

 cgc tat aac acc cac cag cct gag ggc tgc att gct gtg gaa gca gga     1536
 Arg Tyr Asn Thr His Gln Pro Glu Gly Cys Ile Ala Val Glu Ala Gly
             500                 505                 510

 atg gat acc ctt atc atg cat ctc tgc gaa gaa act gcc cca gag aat     1584
 Met Asp Thr Leu Ile Met His Leu Cys Glu Glu Thr Ala Pro Glu Asn
         515                 520                 525

 cag aag ttc atc ttg cag gag gat gga tct tta ttt cac gaa cag tcc     1632
 Gln Lys Phe Ile Leu Gln Glu Asp Gly Ser Leu Phe His Glu Gln Ser
     530                 535                 540

 aag aaa tgt gtc cag gct gcg agg aag gag tcg agt gac agt ttc gtt     1680
 Lys Lys Cys Val Gln Ala Ala Arg Lys Glu Ser Ser Asp Ser Phe Val
 545                 550                 555                 560

 cca ctc tta cga gac tgc acc aac tcg gat cat cag aaa tgg ttc ttc     1728
 Pro Leu Leu Arg Asp Cys Thr Asn Ser Asp His Gln Lys Trp Phe Phe
                 565                 570                 575

 aaa gag cgc atg tta tgaagcctcg tgtatcaagg agcccatcga aggagactgt     1783
 Lys Glu Arg Met Leu 
             580

 ggagccagga ctctgcccaa caaagactta gctaagcagt gaccagaacc caccaaaaac   1843

 taggctgcat tgctttgaag aggcaatcat tttgccattt gtgaaagttg tgttggattt   1903

 agtaaaaatg tgaataagct ttgtacttat tttgagaact ttttaaatgt tccaaaatac   1963

 cctattttca aagggtaatc gtaagatgtt aacccttggt atttagaaaa ttaaaacctt   2023

 ataatatttt tctatcaaaa aaaaaaaa                                      2051




      <210> 183
      <211> 589
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (32)..(532)

      <400> 183
 gggagcccta gggcactggg tcttcagtgg c   atg ggg gtg aag cgg agc ctc      52
                                      Met Gly Val Lys Arg Ser Leu
                                        1               5

 cag agt ggg ggc att ctg ctc agc ctc gtg gcc aac gtc ctc atg gtg      100
 Gln Ser Gly Gly Ile Leu Leu Ser Leu Val Ala Asn Val Leu Met Val
          10                  15                  20

 ctc tcc acg gcc acc aac tac tgg acc cgc caa caa gag ggc cac agt      148
 Leu Ser Thr Ala Thr Asn Tyr Trp Thr Arg Gln Gln Glu Gly His Ser
      25                  30                  35

 ggc ctg tgg cag gaa tgc aac cac ggc atc tgc tcc agc atc ccc tgc      196
 Gly Leu Trp Gln Glu Cys Asn His Gly Ile Cys Ser Ser Ile Pro Cys
  40                  45                  50                  55

 cag acc acg ctg gcg gtg act gtg gcg tgc atg gtg ctg gcg gtg ggt      244
 Gln Thr Thr Leu Ala Val Thr Val Ala Cys Met Val Leu Ala Val Gly
                  60                  65                  70

 gtc ggc gtg gtg ggc atg gtg atg gga ctg cgg att cgg tgc gac gag      292
 Val Gly Val Val Gly Met Val Met Gly Leu Arg Ile Arg Cys Asp Glu
              75                  80                  85

 ggc gag tcg ctg cgg ggc cag acc acg agc gcc ttc ctc ttc ctc ggc      340
 Gly Glu Ser Leu Arg Gly Gln Thr Thr Ser Ala Phe Leu Phe Leu Gly
          90                  95                 100

 gga ctg ctg ctg ctg acc gcc ttg ata ggc tac acc gtg aag aat gcg      388
 Gly Leu Leu Leu Leu Thr Ala Leu Ile Gly Tyr Thr Val Lys Asn Ala
     105                 110                 115

 tgg aag aac aac gtc ttc ttc tct tgg tcc tat ttt tct ggg tgg ctg      436
 Trp Lys Asn Asn Val Phe Phe Ser Trp Ser Tyr Phe Ser Gly Trp Leu
 120                 125                 130                 135

 gcc tta ccc ttc tca att ctc gcg ggc ttc tgc ttt ctg ctg gca gac      484
 Ala Leu Pro Phe Ser Ile Leu Ala Gly Phe Cys Phe Leu Leu Ala Asp
                 140                 145                 150

 atg atc atg cag agc acc gac gcc atc agt gga ttc ccc gtg tgt ctg      532
 Met Ile Met Gln Ser Thr Asp Ala Ile Ser Gly Phe Pro Val Cys Leu 
             155                 160                 165

 tgactgcagc ctgcctgggg cagaataaag gaacggcttt ttttaaaaaa aaaaaaa       589




      <210> 184
      <211> 2715
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (661)..(2712)

      <400> 184
 tttcgtggcg ggtagcatgt gcgggagact cacgttgccg gcgaagtggg agagagaaaa     60

 gtggtaacct ggggctgggg gccggcgcgg cggagctcgg agtagtagag cggagtgaag    120

 acacggggga ggatagagac tggcattcct ttgggccggg ggattggcgg gagtcgtgct    180

 gggtgctctc gccgtgttga ggtcccagtg aggggaagga gaagcggaag agggtctcta    240

 gtcggggcct agggcaaagg gactacaaaa aggatgcaga tgactataga aatgaggacg    300

 acgaggagat gctgtggagg agcagtagag gtgagaagat gatgcaaaga aactgtgtca    360

 gtgaggaact gtatagaggg tcatagaggt gaggtggcgg agagaaacta actaacggac    420

 catagaggtg ggggagccat tgtagaagga cgtggacgcg aaagggtcgt gtagatgggc    480

 atatgtgtga agcagcaacg tagaggggct gaagaggaga aattcatgga gagaaagaat    540

 gcacctagag tgagctctgc agagtgctgc gtgggatatc cctagagttt ggtctagtga    600

 aggcacgcta accaggcacc taaggcattt caagtagtga cttcccacat ttggctagga    660
                                                                 
 atg tgg gtc ctc ctc cga agt ggg tac ccc ctc cgt atc ttg tta ccc      708
 Met Trp Val Leu Leu Arg Ser Gly Tyr Pro Leu Arg Ile Leu Leu Pro
   1               5                  10                  15

 ctg cgt ggg gag tgg atg ggt cgg agg ggc ctg ccc cga aac ttg gcc      756
 Leu Arg Gly Glu Trp Met Gly Arg Arg Gly Leu Pro Arg Asn Leu Ala
              20                  25                  30

 cca ggc cct cct cgc aga cgt tac agg aag gag act ctc caa gcc ttg      804
 Pro Gly Pro Pro Arg Arg Arg Tyr Arg Lys Glu Thr Leu Gln Ala Leu
          35                  40                  45

 gat atg cca gtg ttg cct gta act gca act gaa atc cgc cag tat ttg      852
 Asp Met Pro Val Leu Pro Val Thr Ala Thr Glu Ile Arg Gln Tyr Leu
      50                  55                  60

 cgg ggg cat ggg atc ccc ttc cag gat ggt cac agt tgc ctg cgg gca      900
 Arg Gly His Gly Ile Pro Phe Gln Asp Gly His Ser Cys Leu Arg Ala
  65                  70                  75                  80

 ctg agc ccc ttt gca gag tct tca cag ctc aaa ggc cag act ggt gtt      948
 Leu Ser Pro Phe Ala Glu Ser Ser Gln Leu Lys Gly Gln Thr Gly Val
                  85                  90                  95

 acc act tcc ttc agc ctc ttc att gac aag acc aca ggc cac ttt ctc      996
 Thr Thr Ser Phe Ser Leu Phe Ile Asp Lys Thr Thr Gly His Phe Leu
             100                 105                 110

 tgc atg acc agc cta gca gaa ggg agc tgg gaa gac ttc cag gcc agc     1044
 Cys Met Thr Ser Leu Ala Glu Gly Ser Trp Glu Asp Phe Gln Ala Ser
         115                 120                 125

 gtg gag ggg cga ggg gat ggg gcc agg gag ggg ttt ctg ctt agc aag     1092
 Val Glu Gly Arg Gly Asp Gly Ala Arg Glu Gly Phe Leu Leu Ser Lys
     130                 135                 140

 gca cca gaa ttt gag gac agc gag gag gtc cgg agg atc tgg aac cga     1140
 Ala Pro Glu Phe Glu Asp Ser Glu Glu Val Arg Arg Ile Trp Asn Arg
 145                 150                 155                 160

 gca ata cct ctc tgg gag ctg cct gat cag gag gag gtt cag ctg gct     1188
 Ala Ile Pro Leu Trp Glu Leu Pro Asp Gln Glu Glu Val Gln Leu Ala
                 165                 170                 175

 gat aca atg ttt ggc ctt acc aag gtt aca gat gac aca ctc aag cgt     1236
 Asp Thr Met Phe Gly Leu Thr Lys Val Thr Asp Asp Thr Leu Lys Arg
             180                 185                 190

 ttc agt gtg cga tat ctg cga cct gct cgc agt ctt gtc ttc cct tgg     1284
 Phe Ser Val Arg Tyr Leu Arg Pro Ala Arg Ser Leu Val Phe Pro Trp
         195                 200                 205

 ttc tcc cct ggg ggc tca gga tta cga ggc ctg aag ctc cta gag gct     1332
 Phe Ser Pro Gly Gly Ser Gly Leu Arg Gly Leu Lys Leu Leu Glu Ala
     210                 215                 220

 aaa tgc cag ggg gat gga gtg agc tac gag gaa acc act att ccc cga     1380
 Lys Cys Gln Gly Asp Gly Val Ser Tyr Glu Glu Thr Thr Ile Pro Arg
 225                 230                 235                 240

 ccc agc gcc tac cac aat ctg ttt gga tta cca ctg att agt cgt cga     1428
 Pro Ser Ala Tyr His Asn Leu Phe Gly Leu Pro Leu Ile Ser Arg Arg
                 245                 250                 255

 gat gct gag gtg gta ctg acg agt cgt gag ctt gac agc ctg gcc ttg     1476
 Asp Ala Glu Val Val Leu Thr Ser Arg Glu Leu Asp Ser Leu Ala Leu
             260                 265                 270

 aac cag tcc acg ggg ctg cct acc ctt act cta ccc cga gga acg acc     1524
 Asn Gln Ser Thr Gly Leu Pro Thr Leu Thr Leu Pro Arg Gly Thr Thr
         275                 280                 285

 tgc tta ccc cct gcc tta ctc cct tac ctg gaa cag ttc cgg cgg att     1572
 Cys Leu Pro Pro Ala Leu Leu Pro Tyr Leu Glu Gln Phe Arg Arg Ile
     290                 295                 300

 gta ttc tgg ttg ggg gat gac ctt cgg tcc tgg gaa gcc gcc aag ttg     1620
 Val Phe Trp Leu Gly Asp Asp Leu Arg Ser Trp Glu Ala Ala Lys Leu
 305                 310                 315                 320

 ttt gca cga aaa ctg aac ccc aaa cga tgc ttc ttg gtg cga cca gga     1668
 Phe Ala Arg Lys Leu Asn Pro Lys Arg Cys Phe Leu Val Arg Pro Gly
                 325                 330                 335

 gac cag caa ccc cgt ccc ctg gag gcc ctg aac gga ggc ttc aat ctt     1716
 Asp Gln Gln Pro Arg Pro Leu Glu Ala Leu Asn Gly Gly Phe Asn Leu
             340                 345                 350

 tct cgt att ctt cgt acc gcc ctg cct gcc tgg cac aag tcc atc gta     1764
 Ser Arg Ile Leu Arg Thr Ala Leu Pro Ala Trp His Lys Ser Ile Val
         355                 360                 365

 tct ttc cgg cag ctt cgg gag gag gtg cta gga gaa ctg tca aat gtg     1812
 Ser Phe Arg Gln Leu Arg Glu Glu Val Leu Gly Glu Leu Ser Asn Val
     370                 375                 380

 gag caa gca gct ggc ctc cgc tgg agc cgc ttt cca gac ctc aat cgt     1860
 Glu Gln Ala Ala Gly Leu Arg Trp Ser Arg Phe Pro Asp Leu Asn Arg
 385                 390                 395                 400

 atc ttg aag gga cat cga aag ggc gag ctg acg gtc ttc aca ggg cca     1908
 Ile Leu Lys Gly His Arg Lys Gly Glu Leu Thr Val Phe Thr Gly Pro
                 405                 410                 415

 aca ggc agt gga aag acg aca ttc atc agt gag tat gcc ctg gat ttg     1956
 Thr Gly Ser Gly Lys Thr Thr Phe Ile Ser Glu Tyr Ala Leu Asp Leu
             420                 425                 430

 tgt tcc cag ggg gtg aac aca ctg tgg ggt agc ttc gag atc agc aat     2004
 Cys Ser Gln Gly Val Asn Thr Leu Trp Gly Ser Phe Glu Ile Ser Asn
         435                 440                 445

 gtg aga cta gcc cgg gtc atg ctg aca cag ttt gcc gag ggg cgg ctg     2052
 Val Arg Leu Ala Arg Val Met Leu Thr Gln Phe Ala Glu Gly Arg Leu
     450                 455                 460

 gaa gat caa ctg gac aaa tat gat cac tgg gct gac cgc ttt gag gac     2100
 Glu Asp Gln Leu Asp Lys Tyr Asp His Trp Ala Asp Arg Phe Glu Asp
 465                 470                 475                 480

 ctg ccc ctc tat ttc atg act ttc cat gga cag caa agc atc agg act     2148
 Leu Pro Leu Tyr Phe Met Thr Phe His Gly Gln Gln Ser Ile Arg Thr
                 485                 490                 495

 gta ata gat aca atg caa cat gca gtc tac gtc tat gac att tgt cat     2196
 Val Ile Asp Thr Met Gln His Ala Val Tyr Val Tyr Asp Ile Cys His
             500                 505                 510

 gtg atc atc gac aac ctg cag ttc atg atg ggt cac gag cag ctg tcc     2244
 Val Ile Ile Asp Asn Leu Gln Phe Met Met Gly His Glu Gln Leu Ser
         515                 520                 525

 aca gac agg atc gca gct caa gac tac atc atc ggg gtc ttt cgg aag     2292
 Thr Asp Arg Ile Ala Ala Gln Asp Tyr Ile Ile Gly Val Phe Arg Lys
     530                 535                 540

 ttt gca aca gac aat aac tgc cat gtg aca ctg gtc att cac ccc cgg     2340
 Phe Ala Thr Asp Asn Asn Cys His Val Thr Leu Val Ile His Pro Arg
 545                 550                 555                 560

 aaa gag gat gat gac aag gaa ctg cag aca gcg tcc att ttt ggc tca     2388
 Lys Glu Asp Asp Asp Lys Glu Leu Gln Thr Ala Ser Ile Phe Gly Ser
                 565                 570                 575

 gcc aaa gca agc cag gaa gca gac aat gtt ctg atc ctg cag gac agg     2436
 Ala Lys Ala Ser Gln Glu Ala Asp Asn Val Leu Ile Leu Gln Asp Arg
             580                 585                 590

 aag ctg gta acc ggg cca ggg aaa cgg tat ctg cag gtg tcc aag aac     2484
 Lys Leu Val Thr Gly Pro Gly Lys Arg Tyr Leu Gln Val Ser Lys Asn
         595                 600                 605

 cgc ttt gat gga gat gta ggt gtc ttc ccg ctt gag ttc aac aag aac     2532
 Arg Phe Asp Gly Asp Val Gly Val Phe Pro Leu Glu Phe Asn Lys Asn
     610                 615                 620

 tcc ctc acc ttc tcc att cca cca aag aac aag gcc cgg ctc aag aag     2580
 Ser Leu Thr Phe Ser Ile Pro Pro Lys Asn Lys Ala Arg Leu Lys Lys
 625                 630                 635                 640

 atc aag gat gac act gga cca gtg gcc aaa aag ccc tct tct ggc aaa     2628
 Ile Lys Asp Asp Thr Gly Pro Val Ala Lys Lys Pro Ser Ser Gly Lys
                 645                 650                 655

 aag ggg gct acg aca cag aac tct gag att tgc tca ggc cag gcc ccc     2676
 Lys Gly Ala Thr Thr Gln Asn Ser Glu Ile Cys Ser Gly Gln Ala Pro
             660                 665                 670

 act ccc gac cag cca gac acc tcc aag cgt tca aag tga                 2715
 Thr Pro Asp Gln Pro Asp Thr Ser Lys Arg Ser Lys 
         675                 680





      <210> 185
      <211> 1749
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (49)..(1503)

      <400> 185
 tttcgtaggt cttcccgcca cactccagag cggatgtgag gggcgccg atg gcg gag      57
                                                      Met Ala Glu
                                                        1

 gga acg gcg gag gct cct cta gag aat ggt ggt ggt ggc gac tcg gga      105
 Gly Thr Ala Glu Ala Pro Leu Glu Asn Gly Gly Gly Gly Asp Ser Gly
       5                  10                  15

 gcc gga gct ttg gaa cga gga gtg gcg ccc att aag cgt caa tac ctc      153
 Ala Gly Ala Leu Glu Arg Gly Val Ala Pro Ile Lys Arg Gln Tyr Leu
  20                  25                  30                  35

 acc acc aag gag cag ttt cac caa ttc ctg gaa gcc aaa ggg cag gag      201
 Thr Thr Lys Glu Gln Phe His Gln Phe Leu Glu Ala Lys Gly Gln Glu
                  40                  45                  50

 aag act tgc cgg gaa acc gag gta gga gac cct gct ggc aat gag ctg      249
 Lys Thr Cys Arg Glu Thr Glu Val Gly Asp Pro Ala Gly Asn Glu Leu
              55                  60                  65

 gct gag cct gag gct aag cgg atc cga ctg gag gat gga cag acg gcg      297
 Ala Glu Pro Glu Ala Lys Arg Ile Arg Leu Glu Asp Gly Gln Thr Ala
          70                  75                  80

 gac ggg cag acg gag gag gca gca gag ccc ggg gag cag cta cag act      345
 Asp Gly Gln Thr Glu Glu Ala Ala Glu Pro Gly Glu Gln Leu Gln Thr
      85                  90                  95

 cag aag agg gcc cgg gga caa aac aag ggc cgg ccc cat gtg aag ccc      393
 Gln Lys Arg Ala Arg Gly Gln Asn Lys Gly Arg Pro His Val Lys Pro
 100                 105                 110                 115

 acg aac tac gac aag aac agg ctg tgt ccc tcc cta atc cag gag tcg      441
 Thr Asn Tyr Asp Lys Asn Arg Leu Cys Pro Ser Leu Ile Gln Glu Ser
                 120                 125                 130

 gct gct aag tgt ttc ttc ggt gat cgc tgc cgc ttt ctg cac gac gtg      489
 Ala Ala Lys Cys Phe Phe Gly Asp Arg Cys Arg Phe Leu His Asp Val
             135                 140                 145

 ggg cgc tac ctg gag acc aag ccg gcc gac ctg ggc ccc cgc tgc gtg      537
 Gly Arg Tyr Leu Glu Thr Lys Pro Ala Asp Leu Gly Pro Arg Cys Val
         150                 155                 160

 ctc ttc gag acc ttc ggc cgg tgc ccc tac ggc gtg acc tgc cgc ttc      585
 Leu Phe Glu Thr Phe Gly Arg Cys Pro Tyr Gly Val Thr Cys Arg Phe
     165                 170                 175

 gct ggg gcc cac ctg agg ccc gag gga cag aac ctg gag cag gag gag      633
 Ala Gly Ala His Leu Arg Pro Glu Gly Gln Asn Leu Glu Gln Glu Glu
 180                 185                 190                 195

 ttg gcg gcc cgc ggg acc cag ccc ccg tcc atc cgc aac ggc ctg gac      681
 Leu Ala Ala Arg Gly Thr Gln Pro Pro Ser Ile Arg Asn Gly Leu Asp
                 200                 205                 210

 aaa gcc ctg cag cag cag ctg cgg aag cgc gag gtc cgc ttc gag cga      729
 Lys Ala Leu Gln Gln Gln Leu Arg Lys Arg Glu Val Arg Phe Glu Arg
             215                 220                 225

 gct gag cag gcc ctg cgc cgg ttc agc cag ggc ccc aca ccc gct gcc      777
 Ala Glu Gln Ala Leu Arg Arg Phe Ser Gln Gly Pro Thr Pro Ala Ala
         230                 235                 240

 gct gtc ccc gag ggc acg gca gcc gag ggc gct ccc agg cag gaa aac      825
 Ala Val Pro Glu Gly Thr Ala Ala Glu Gly Ala Pro Arg Gln Glu Asn
     245                 250                 255

 tgt ggt gcc cag cag gtc ccc gca ggg ccg ggc act agc acc cct ccc      873
 Cys Gly Ala Gln Gln Val Pro Ala Gly Pro Gly Thr Ser Thr Pro Pro
 260                 265                 270                 275

 agc agc ccc gtg cgg acc tgc ggg ccc ctg acg gat gag gac gtg gtc      921
 Ser Ser Pro Val Arg Thr Cys Gly Pro Leu Thr Asp Glu Asp Val Val
                 280                 285                 290

 agg ctg cgg ccc tgt gag aag aag cgg ctg gac atc cgt ggc aaa ctt      969
 Arg Leu Arg Pro Cys Glu Lys Lys Arg Leu Asp Ile Arg Gly Lys Leu
             295                 300                 305

 tac ctg gcc ccc ctc acc acg tgt ggg aac ctg ccc ttc cga cgg atc     1017
 Tyr Leu Ala Pro Leu Thr Thr Cys Gly Asn Leu Pro Phe Arg Arg Ile
         310                 315                 320

 tgc aag cgc ttc ggg gcg gat gtg aca tgt gga gag atg gcc gtc tgc     1065
 Cys Lys Arg Phe Gly Ala Asp Val Thr Cys Gly Glu Met Ala Val Cys
     325                 330                 335

 acc aac ctg ctg cag ggc cag atg tcc gag tgg gcc cta ctc aaa cgc     1113
 Thr Asn Leu Leu Gln Gly Gln Met Ser Glu Trp Ala Leu Leu Lys Arg
 340                 345                 350                 355

 cac cag tgt gag gac atc ttt ggc gtc cag ctg gag ggc gcc ttc ccc     1161
 His Gln Cys Glu Asp Ile Phe Gly Val Gln Leu Glu Gly Ala Phe Pro
                 360                 365                 370

 gac acc atg acc aag tgt gcc gag ctg ctg agc cgc acc gtg gag gtg     1209
 Asp Thr Met Thr Lys Cys Ala Glu Leu Leu Ser Arg Thr Val Glu Val
             375                 380                 385

 gac ttt gtg gac atc aac gtc ggc tgc ccc atc gac ctc gtg tac aag     1257
 Asp Phe Val Asp Ile Asn Val Gly Cys Pro Ile Asp Leu Val Tyr Lys
         390                 395                 400

 aag ggt ggg ggc tgt gcc ctc atg aat cgc tcc acc aag ttc cag cag     1305
 Lys Gly Gly Gly Cys Ala Leu Met Asn Arg Ser Thr Lys Phe Gln Gln
     405                 410                 415

 atc gtc cgt ggc atg aac cag gtg ctg gat gtg ccg ctg act gtg aag     1353
 Ile Val Arg Gly Met Asn Gln Val Leu Asp Val Pro Leu Thr Val Lys
 420                 425                 430                 435

 atc cgc aca ggc gtc cag gag cgt gtg aac ctg gcg cac cgc ctg ctg     1401
 Ile Arg Thr Gly Val Gln Glu Arg Val Asn Leu Ala His Arg Leu Leu
                 440                 445                 450

 ccc gag ctg cgg gac tgg ggc gtg gca ctc gtc acg gaa atg ggg aca     1449
 Pro Glu Leu Arg Asp Trp Gly Val Ala Leu Val Thr Glu Met Gly Thr
             455                 460                 465

 tct tgt cat ttg agg atg cca acc gcg cca tgc aga ctg gtg tca ccg     1497
 Ser Cys His Leu Arg Met Pro Thr Ala Pro Cys Arg Leu Val Ser Pro
         470                 475                 480

 gga tca tgattgcccg tggcgccctg ctcaagccgt ggctcttcac ggagatcaag      1553
 Gly Ser 
     485

 gagcagcggc actgggacat ctcgtcgtcc gagcgcctgg acatcctgcg ggacttcacc   1613

 aactacggcc tggagcactg gggctcggac acgcagggcg tggagaagac ccggcgcttt   1673

 ctgctcgagt ggctgtcctt cctgtgccgg tacgtgcccg tggggctgct ggagcggctc   1733

 ccacagagga tcaacg                                                   1749




      <210> 186
      <211> 2637
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (200)..(2215)

      <400> 186
 tcgcagcagc gtactgacgt cacgcaggac gccactgccc tgtcgccccg cctgtgcagc     60

 ccaggaccta ggcgcggtag ctggggctgg cttttgaggg gcgcgggcag ccttctgact    120

 gggtcggagg cctgcgggcc cgaagcctct gtccctcctg ttcttgtccg gcgctgctta    180

 gcccctccgc gtagtcatc atg gat ctg att tta aac cga atg gat tat ctg     232
                      Met Asp Leu Ile Leu Asn Arg Met Asp Tyr Leu
                        1               5                  10

 cag gtg gga gta aca tct cag aag act atg aag cta att cct gcc tca      280
 Gln Val Gly Val Thr Ser Gln Lys Thr Met Lys Leu Ile Pro Ala Ser
              15                  20                  25

 aga cac aga gct aca caa aag gtg gtt att gga gat cat gat ggg gta      328
 Arg His Arg Ala Thr Gln Lys Val Val Ile Gly Asp His Asp Gly Val
          30                  35                  40

 gtt atg tgc ttt ggc atg aag aaa gga gaa gca gca gca gtg ttc aag      376
 Val Met Cys Phe Gly Met Lys Lys Gly Glu Ala Ala Ala Val Phe Lys
      45                  50                  55

 act tta ccc ggg ccg aag att gca agg ctg gaa ctg gga ggg gtt atc      424
 Thr Leu Pro Gly Pro Lys Ile Ala Arg Leu Glu Leu Gly Gly Val Ile
  60                  65                  70                  75

 aac aca cct cag gag aaa att ttt att gct gca gca tct gag att aga      472
 Asn Thr Pro Gln Glu Lys Ile Phe Ile Ala Ala Ala Ser Glu Ile Arg
                  80                  85                  90

 ggc ttc aca aaa aga gga aaa cag ttc ctc tcc ttt gaa aca aac ctc      520
 Gly Phe Thr Lys Arg Gly Lys Gln Phe Leu Ser Phe Glu Thr Asn Leu
              95                 100                 105

 act gaa agc att aaa gct atg cac ata tct ggc tca gac ctc ttt ctc      568
 Thr Glu Ser Ile Lys Ala Met His Ile Ser Gly Ser Asp Leu Phe Leu
         110                 115                 120

 agt gca agt tac atc tat aac cat tat tgt gac tgc aaa gac caa cat      616
 Ser Ala Ser Tyr Ile Tyr Asn His Tyr Cys Asp Cys Lys Asp Gln His
     125                 130                 135

 tat tac ctt tct ggg gat aaa atc aat gat gtg atc tgc ctt cca gtg      664
 Tyr Tyr Leu Ser Gly Asp Lys Ile Asn Asp Val Ile Cys Leu Pro Val
 140                 145                 150                 155

 gaa aga tta tct cgt atc aca cct gta ttg gcc tgc cag gac aga gtg      712
 Glu Arg Leu Ser Arg Ile Thr Pro Val Leu Ala Cys Gln Asp Arg Val
                 160                 165                 170

 ctc aga gtt tta cag gga tct gat gtg atg tat gca gtt gaa gtt cct      760
 Leu Arg Val Leu Gln Gly Ser Asp Val Met Tyr Ala Val Glu Val Pro
             175                 180                 185

 gga ccc cct act gtc tta gca cta cac aat gga aat ggc ggt gac tct      808
 Gly Pro Pro Thr Val Leu Ala Leu His Asn Gly Asn Gly Gly Asp Ser
         190                 195                 200

 gga gaa gac ctt ttg ttt ggg aca tca gac gga aaa ctt gcg ctt ata      856
 Gly Glu Asp Leu Leu Phe Gly Thr Ser Asp Gly Lys Leu Ala Leu Ile
     205                 210                 215

 cag att act aca tcc aaa cca gta cgc aag tgg gaa att caa aat gag      904
 Gln Ile Thr Thr Ser Lys Pro Val Arg Lys Trp Glu Ile Gln Asn Glu
 220                 225                 230                 235

 aaa aag aga gga ggt att ttg tgt att gac agc ttt gac att gtg ggt      952
 Lys Lys Arg Gly Gly Ile Leu Cys Ile Asp Ser Phe Asp Ile Val Gly
                 240                 245                 250

 gat ggg gtt aaa gat tta ctt gtt ggg aga gat gac gga atg gtg gaa     1000
 Asp Gly Val Lys Asp Leu Leu Val Gly Arg Asp Asp Gly Met Val Glu
             255                 260                 265

 gtg tat agt ttt gat aat gca aat gaa cct gtt cta cga ttt gat cag     1048
 Val Tyr Ser Phe Asp Asn Ala Asn Glu Pro Val Leu Arg Phe Asp Gln
         270                 275                 280

 atg ttg tct gaa agc gtc aca tct atc cag ggt ggt tgt gta gga aaa     1096
 Met Leu Ser Glu Ser Val Thr Ser Ile Gln Gly Gly Cys Val Gly Lys
     285                 290                 295

 gac agc tat gat gaa atc gtg gtg tcc aca tat tca ggc tgg gtt aca     1144
 Asp Ser Tyr Asp Glu Ile Val Val Ser Thr Tyr Ser Gly Trp Val Thr
 300                 305                 310                 315

 ggt ctg aca aca gag ccc att cat aag gaa agt gga cca gga gaa gaa     1192
 Gly Leu Thr Thr Glu Pro Ile His Lys Glu Ser Gly Pro Gly Glu Glu
                 320                 325                 330

 cta aaa att aat cag gag atg cag aat aaa att tct tcc tta cgg aat     1240
 Leu Lys Ile Asn Gln Glu Met Gln Asn Lys Ile Ser Ser Leu Arg Asn
             335                 340                 345

 gag ttg gaa cat ttg cag tat aag gta ttg cag gaa aga gag aat tat     1288
 Glu Leu Glu His Leu Gln Tyr Lys Val Leu Gln Glu Arg Glu Asn Tyr
         350                 355                 360

 caa cag tct tct caa tca agc aaa gca aaa tca gca gta cct tcc ttt     1336
 Gln Gln Ser Ser Gln Ser Ser Lys Ala Lys Ser Ala Val Pro Ser Phe
     365                 370                 375

 ggt ata aat gat aaa ttt aca cta aat aaa gat gat gcc agt tac agc     1384
 Gly Ile Asn Asp Lys Phe Thr Leu Asn Lys Asp Asp Ala Ser Tyr Ser
 380                 385                 390                 395

 ctt atc tta gag gta cag act gca ata gat aat gtc tta ata cag agt     1432
 Leu Ile Leu Glu Val Gln Thr Ala Ile Asp Asn Val Leu Ile Gln Ser
                 400                 405                 410

 gat gtt cca ata gat tta ctt gat gtg gat aaa aat tct gct gtt gtt     1480
 Asp Val Pro Ile Asp Leu Leu Asp Val Asp Lys Asn Ser Ala Val Val
             415                 420                 425

 agc ttt agc agc tgt gat tct gag tca aac gac aac ttc ctt ctt gcc     1528
 Ser Phe Ser Ser Cys Asp Ser Glu Ser Asn Asp Asn Phe Leu Leu Ala
         430                 435                 440

 act tat cgg tgc cag gca gat act aca agg ctg gaa ctc aag att cgc     1576
 Thr Tyr Arg Cys Gln Ala Asp Thr Thr Arg Leu Glu Leu Lys Ile Arg
     445                 450                 455

 tca att gaa ggc cag tat ggc aca cta caa gca tat gtg act cca aga     1624
 Ser Ile Glu Gly Gln Tyr Gly Thr Leu Gln Ala Tyr Val Thr Pro Arg
 460                 465                 470                 475

 att caa ccc aaa acc tgt cag gtc cgc cag tac cac atc aaa cct ctt     1672
 Ile Gln Pro Lys Thr Cys Gln Val Arg Gln Tyr His Ile Lys Pro Leu
                 480                 485                 490

 tca ctc cat caa aga act cac ttt att gat cat gac aga ccc atg aat     1720
 Ser Leu His Gln Arg Thr His Phe Ile Asp His Asp Arg Pro Met Asn
             495                 500                 505

 aca ctg acc cta aca ggc cag ttc agt ttt gct gaa gtt cac tcc tgg     1768
 Thr Leu Thr Leu Thr Gly Gln Phe Ser Phe Ala Glu Val His Ser Trp
         510                 515                 520

 gtg gtt ttt tgt ctg cct gaa gtt cca gaa aaa cct cca gca gga gaa     1816
 Val Val Phe Cys Leu Pro Glu Val Pro Glu Lys Pro Pro Ala Gly Glu
     525                 530                 535

 tgt gtg aca ttt tac ttt cag aac acc ttt cta gat aca caa ctt gaa     1864
 Cys Val Thr Phe Tyr Phe Gln Asn Thr Phe Leu Asp Thr Gln Leu Glu
 540                 545                 550                 555

 agt acc tac aga aaa gga gag gga gtt ttt aaa tct gac aac att tct     1912
 Ser Thr Tyr Arg Lys Gly Glu Gly Val Phe Lys Ser Asp Asn Ile Ser
                 560                 565                 570

 act atc tcc atc cta aaa gat gtg ctt tct aaa gaa gct aca aaa agg     1960
 Thr Ile Ser Ile Leu Lys Asp Val Leu Ser Lys Glu Ala Thr Lys Arg
             575                 580                 585

 aaa att aac ctc aac ata tca tac gag ata aat gaa gta tca gtc aaa     2008
 Lys Ile Asn Leu Asn Ile Ser Tyr Glu Ile Asn Glu Val Ser Val Lys
         590                 595                 600

 cac act tta aag cta atc cac cca aag ctg gag tac cag ttg ctt ttg     2056
 His Thr Leu Lys Leu Ile His Pro Lys Leu Glu Tyr Gln Leu Leu Leu
     605                 610                 615

 gct aag aaa gtg cag tta att gat gct tta aaa gaa tta cag att cat     2104
 Ala Lys Lys Val Gln Leu Ile Asp Ala Leu Lys Glu Leu Gln Ile His
 620                 625                 630                 635

 gag gga aat acg aac ttt ctg ata cca gaa tat cac tgt att cta gaa     2152
 Glu Gly Asn Thr Asn Phe Leu Ile Pro Glu Tyr His Cys Ile Leu Glu
                 640                 645                 650

 gag gca gat cac cta cag gaa gaa tac aaa aag caa cct gca cat ctt     2200
 Glu Ala Asp His Leu Gln Glu Glu Tyr Lys Lys Gln Pro Ala His Leu
             655                 660                 665

 gaa aga ctc tat ggt tagtggacca ttctagaata ccttgccata tttcttttca     2255
 Glu Arg Leu Tyr Gly 
         670

 actggctatt tcccaaggat catgtaagag aagctgggca gaaagataaa aagattacat   2315

 cagtcatgat tcatgaacca gtcatgaatc agttgacaac aaatttattg cacagaatat   2375

 ttctgtattt tgtcaagcta cttttaatat ttaattcttt tacttgataa aatgcaagta   2435

 tattaagaaa taagtatact gtgatgaatt aatctatata tatgaacaaa cctggtataa   2495

 aatgaatgta atctatgaac ctttagagct tagactgtat ttcacacaaa taattgtcat   2555

 gttttgttgc tattgtgaat tataaaaatg cagcatttaa aatttttaag gcaaaattta   2615

 ataaaggata tacagtaaaa aa                                            2637




      <210> 187
      <211> 1029
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (261)..(905)

      <400> 187
 acagtttgag aaccgtcggc cgacccacgc gtccggcagt agatcgcgat ctagaactag     60

 tccggacgcg tgggaaagac ttcttttgag ctaactttct tatactggta cctttctaat    120

 ctcactacaa tatgtaacat tggtgttcga tctcaagtat ttctgaatat attcccctat    180

 ccacagaaat atactctggg ggaaaaaaaa tagaacaaat tcttgccgtc ctgaccattg    240

 aacaagagac taattagaca    atg ggg cta gaa aaa cct caa agt aaa ctg     290
                          Met Gly Leu Glu Lys Pro Gln Ser Lys Leu
                            1               5                  10

 gaa gga ggc atg cat ccc cag ctg ata cct tcg gtt att gct gta gtt      338
 Glu Gly Gly Met His Pro Gln Leu Ile Pro Ser Val Ile Ala Val Val
                  15                  20                  25

 ttc atc tta ctt ctc ggt gtc tgt ttt att gca agt tgt ttg gtg act      386
 Phe Ile Leu Leu Leu Gly Val Cys Phe Ile Ala Ser Cys Leu Val Thr
              30                  35                  40

 cat cac aac ttt tca cgc tgt aag aga ggc aca gga gtg cac aag tta      434
 His His Asn Phe Ser Arg Cys Lys Arg Gly Thr Gly Val His Lys Leu
          45                  50                  55

 gag cac cat gca aag ctc aaa tgc atc aaa gag aaa tca gaa ctg aaa      482
 Glu His His Ala Lys Leu Lys Cys Ile Lys Glu Lys Ser Glu Leu Lys
      60                  65                  70

 agt gct gaa ggg agc acc tgg aac tgt tgt cct att gac tgg aga gcc      530
 Ser Ala Glu Gly Ser Thr Trp Asn Cys Cys Pro Ile Asp Trp Arg Ala
  75                  80                  85                  90

 ttc cag tcc aac tgc tat ttt cct ctt act gac aac aag acg tgg gct      578
 Phe Gln Ser Asn Cys Tyr Phe Pro Leu Thr Asp Asn Lys Thr Trp Ala
                  95                 100                 105

 gag agt gaa agg aac tgt tca ggg atg ggg gcc cat ctg atg acc atc      626
 Glu Ser Glu Arg Asn Cys Ser Gly Met Gly Ala His Leu Met Thr Ile
             110                 115                 120

 agc acg gaa gct gag cag aac ttt att att cag ttt ctg gat aga cgg      674
 Ser Thr Glu Ala Glu Gln Asn Phe Ile Ile Gln Phe Leu Asp Arg Arg
         125                 130                 135

 ctt tcc tat ttc ctt gga ctt aga gat gag aat gcc aaa ggt cag tgg      722
 Leu Ser Tyr Phe Leu Gly Leu Arg Asp Glu Asn Ala Lys Gly Gln Trp
     140                 145                 150

 cgt tgg gtg gac cag acg cca ttt aac cca cgc aga gta ttc tgg cat      770
 Arg Trp Val Asp Gln Thr Pro Phe Asn Pro Arg Arg Val Phe Trp His
 155                 160                 165                 170

 aag aat gaa ccc gac aac tct cag gga gaa aac tgt gtt gtt ctt gtt      818
 Lys Asn Glu Pro Asp Asn Ser Gln Gly Glu Asn Cys Val Val Leu Val
                 175                 180                 185

 tat aac caa gat aaa tgg gcc tgg aat gat gtt cct tgt aac ttt gaa      866
 Tyr Asn Gln Asp Lys Trp Ala Trp Asn Asp Val Pro Cys Asn Phe Glu
             190                 195                 200

 gca agt agg att tgt aaa ata cct gga aca aca ttg aac tagaaactca       915
 Ala Ser Arg Ile Cys Lys Ile Pro Gly Thr Thr Leu Asn 
         205                 210                 215

 gaaagtggtc cttgtgatgg aaagagaaaa gaaaaccaat tagaataagg cagaatgtac    975

 gtgcgtcatt ggaacacaga aaacatgctg gttcatacag aaaaaaaaaa aaaa         1029




      <210> 188
      <211> 368
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (22)..(234)

      <400> 188
 ttcttttaga actccattga t  atg tgt agc tat gta agt agt atg tgt atg      51
                          Met Cys Ser Tyr Val Ser Ser Met Cys Met
                            1               5                  10

 tgc gtg tgt ata tat acg tat gtc tgt aca ggt ata tat aca tgc ata       99
 Cys Val Cys Ile Tyr Thr Tyr Val Cys Thr Gly Ile Tyr Thr Cys Ile
                  15                  20                  25

 tac tac ttg tat ata cac aca tgc tgc tta ata cat gtg tat agt cat      147
 Tyr Tyr Leu Tyr Ile His Thr Cys Cys Leu Ile His Val Tyr Ser His
              30                  35                  40

 gta tat ata cac gtg tat atg tat att aca ttt ata cac ata cat ttt      195
 Val Tyr Ile His Val Tyr Met Tyr Ile Thr Phe Ile His Ile His Phe
          45                  50                  55

 tta tat gtt aat agt gat tct cag tgg tgg cat tac aag tgatctttat       244
 Leu Tyr Val Asn Ser Asp Ser Gln Trp Trp His Tyr Lys 
      60                  65                  70

 tttccttaca tttaaaaaaa ttgagtgcat ttttacaaat aataaaatat gttttaaaca    304

 atcattaata cctttttaga aaaacaggat gaagttgtct attacgatcc atgtgaaagt    364

 ccag                                                                 368




      <210> 189
      <211> 1958
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (64)..(1821)

      <400> 189
 ggtgcccacc ctggcagcat cccacctcct gagtcctctc ggcacccagc aaggttgaag     60

 ttc  atg agt tcg ccc agc ctc agt gac ctg ggc aag aga gag ccg gcc     108
      Met Ser Ser Pro Ser Leu Ser Asp Leu Gly Lys Arg Glu Pro Ala
        1               5                  10                  15

 gtc gcc gcg gac gag cgg ggc acg cag cag cgc cgg gcc tac gcc aac      156
 Val Ala Ala Asp Glu Arg Gly Thr Gln Gln Arg Arg Ala Tyr Ala Asn
                  20                  25                  30

 gcc acc tgg aac agc atc cac aac ggg gtg atc gcc gtc ttc cag cgc      204
 Ala Thr Trp Asn Ser Ile His Asn Gly Val Ile Ala Val Phe Gln Arg
              35                  40                  45

 aag ggg ctg ccc gac cag gag ctc ttc agc ctc aac gag ggc gtc cgg      252
 Lys Gly Leu Pro Asp Gln Glu Leu Phe Ser Leu Asn Glu Gly Val Arg
          50                  55                  60

 cag ctg ttg aag aca gag ctg ggg tcc ttc ttc acg gag tac ctg cag      300
 Gln Leu Leu Lys Thr Glu Leu Gly Ser Phe Phe Thr Glu Tyr Leu Gln
      65                  70                  75

 aac cag ctg ctg aca aaa ggc atg gtg atc ctt cgg gac aag att cgc      348
 Asn Gln Leu Leu Thr Lys Gly Met Val Ile Leu Arg Asp Lys Ile Arg
  80                  85                  90                  95

 ttc tat gag gag ctg cag aga gac aag gcg gcg gcg gct gct gtg ctg      396
 Phe Tyr Glu Glu Leu Gln Arg Asp Lys Ala Ala Ala Ala Ala Val Leu
                 100                 105                 110

 ggt gca gtg agg aag agg ccc tcg gtg gtg ccc atg gct ggc cag gat      444
 Gly Ala Val Arg Lys Arg Pro Ser Val Val Pro Met Ala Gly Gln Asp
             115                 120                 125

 cct gcg ctg agc acg agt cac ccg ttc tac gac gtg gcc aga cat ggc      492
 Pro Ala Leu Ser Thr Ser His Pro Phe Tyr Asp Val Ala Arg His Gly
         130                 135                 140

 att ctg cag gtg gca ggg gat gac cgc ttt gga aga cgt gtt gtc acg      540
 Ile Leu Gln Val Ala Gly Asp Asp Arg Phe Gly Arg Arg Val Val Thr
     145                 150                 155

 ttc agc tgc tgc cgg atg ccg ccc tcc cac gag ctg gac cac cag cgg      588
 Phe Ser Cys Cys Arg Met Pro Pro Ser His Glu Leu Asp His Gln Arg
 160                 165                 170                 175

 ctg ctg gag tat ttg aag tac aca ctg gac caa tac gtt gag aac gat      636
 Leu Leu Glu Tyr Leu Lys Tyr Thr Leu Asp Gln Tyr Val Glu Asn Asp
                 180                 185                 190

 tat acc atc gtc tat ttc cac tac ggg ctg aac agc cgg aac aag cct      684
 Tyr Thr Ile Val Tyr Phe His Tyr Gly Leu Asn Ser Arg Asn Lys Pro
             195                 200                 205

 tcc ctg ggc tgg ctc cag agc gca tac aag gag ttc gat agg aaa gac      732
 Ser Leu Gly Trp Leu Gln Ser Ala Tyr Lys Glu Phe Asp Arg Lys Asp
         210                 215                 220

 ggg gat ctc act atg tgg ccc agg ctg gtc tcg aac tcc aag ctc aag      780
 Gly Asp Leu Thr Met Trp Pro Arg Leu Val Ser Asn Ser Lys Leu Lys
     225                 230                 235

 cga tcc tcc cac ctc agc ctc cca aag tac tgg gat tac agg tac aag      828
 Arg Ser Ser His Leu Ser Leu Pro Lys Tyr Trp Asp Tyr Arg Tyr Lys
 240                 245                 250                 255

 aag aac ttg aag gcc ctc tac gtg gtg cac ccc acc agc ttc atc aag      876
 Lys Asn Leu Lys Ala Leu Tyr Val Val His Pro Thr Ser Phe Ile Lys
                 260                 265                 270

 gtc ctg tgg aac atc ttg aag ccc ctc atc agt cac aag ttt ggg aag      924
 Val Leu Trp Asn Ile Leu Lys Pro Leu Ile Ser His Lys Phe Gly Lys
             275                 280                 285

 aaa gtc atc tat ttc aac tac ctg agt gag ctc cac gaa cac ctt aaa      972
 Lys Val Ile Tyr Phe Asn Tyr Leu Ser Glu Leu His Glu His Leu Lys
         290                 295                 300

 tac gac cag ctg gtc atc cct ccc gaa gtt ttg cgg tac gat gag aag     1020
 Tyr Asp Gln Leu Val Ile Pro Pro Glu Val Leu Arg Tyr Asp Glu Lys
     305                 310                 315

 ctc cag agc ctg cac gag ggc cgg acg ccg cct ccc acc aag aca cca     1068
 Leu Gln Ser Leu His Glu Gly Arg Thr Pro Pro Pro Thr Lys Thr Pro
 320                 325                 330                 335

 ccg ccg cgg ccc ccg ctg ccc aca cag cag ttt ggc gtc agt ctg caa     1116
 Pro Pro Arg Pro Pro Leu Pro Thr Gln Gln Phe Gly Val Ser Leu Gln
                 340                 345                 350

 tac ctc aaa gac aaa aat caa ggc gaa ctc atc ccc cct gtg ctg agg     1164
 Tyr Leu Lys Asp Lys Asn Gln Gly Glu Leu Ile Pro Pro Val Leu Arg
             355                 360                 365

 ttc aca gtg acg tac ctg aga gag aaa ggc ctg cgc acc gag ggc ctg     1212
 Phe Thr Val Thr Tyr Leu Arg Glu Lys Gly Leu Arg Thr Glu Gly Leu
         370                 375                 380

 ttc cgg aga tcc gcc agc gtg cag acc gtc cgc gag atc cag agg ctc     1260
 Phe Arg Arg Ser Ala Ser Val Gln Thr Val Arg Glu Ile Gln Arg Leu
     385                 390                 395

 tac aac caa ggg aag ccc gtg aac ttt gac gac tac ggg gac att cac     1308
 Tyr Asn Gln Gly Lys Pro Val Asn Phe Asp Asp Tyr Gly Asp Ile His
 400                 405                 410                 415

 atc cct gcc gtg atc ctg aag acc ttc ctg cga gag ctg ccc cag ccg     1356
 Ile Pro Ala Val Ile Leu Lys Thr Phe Leu Arg Glu Leu Pro Gln Pro
                 420                 425                 430

 ctt ctg acc ttc cag gcc tac gag cag att ctt ggg atc acc tgt gtg     1404
 Leu Leu Thr Phe Gln Ala Tyr Glu Gln Ile Leu Gly Ile Thr Cys Val
             435                 440                 445

 gag agc agc ctg cgt gtc act ggc tgc cgc cag atc tta cgg agc ctc     1452
 Glu Ser Ser Leu Arg Val Thr Gly Cys Arg Gln Ile Leu Arg Ser Leu
         450                 455                 460

 cca gag cac aac tac gtc gtc ctc cgc tac ctc atg ggc ttc ctg cat     1500
 Pro Glu His Asn Tyr Val Val Leu Arg Tyr Leu Met Gly Phe Leu His
     465                 470                 475

 gcg gtg tcc cgg gag agc atc ttc aac aaa atg aac agc tct aac ctg     1548
 Ala Val Ser Arg Glu Ser Ile Phe Asn Lys Met Asn Ser Ser Asn Leu
 480                 485                 490                 495

 gcc tgt gtc ttc ggg ctg aat ttg atc tgg cca tcc cag ggg gtc tcc     1596
 Ala Cys Val Phe Gly Leu Asn Leu Ile Trp Pro Ser Gln Gly Val Ser
                 500                 505                 510

 tcc ctg agt gcc ctt gtg ccc ctg aac atg ttc act gaa ctg ctg atc     1644
 Ser Leu Ser Ala Leu Val Pro Leu Asn Met Phe Thr Glu Leu Leu Ile
             515                 520                 525

 gag tac tat gaa aag atc ttc agc acc ccg gag gca cct ggg gag cac     1692
 Glu Tyr Tyr Glu Lys Ile Phe Ser Thr Pro Glu Ala Pro Gly Glu His
         530                 535                 540

 ggc ctg gca cca tgg gaa cag ggg agc agg gca gcc cct ttg cag gag     1740
 Gly Leu Ala Pro Trp Glu Gln Gly Ser Arg Ala Ala Pro Leu Gln Glu
     545                 550                 555

 gct gtg cca cgg aca caa gcc acg ggc ctc acc aag cct acc cta cct     1788
 Ala Val Pro Arg Thr Gln Ala Thr Gly Leu Thr Lys Pro Thr Leu Pro
 560                 565                 570                 575

 ccg agt ccc ctg atg gca gcc aga aga cgt ctc tagtgttg cgaacactct     1839
 Pro Ser Pro Leu Met Ala Ala Arg Arg Arg Leu 
                 580                 585

 gtatgtttcg agctacctcc cacacctgtc tgtgcacttg tatgttttat aaacttggca   1899

 tctgtaaaaa taaccagcca ttagatgaat tcagaacctt ctaatgaaaa aaaaaaaaa    1958




      <210> 190
      <211> 1865
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (64)..(1728)

      <400> 190
 ggtgcccacc ctggcagcat cccacctcct gagtcctctc ggcacccagc aaggttgaag     60

 ttc  atg agt tcg ccc agc ctc agt gac ctg ggc aag aga gag ccg gcc     108
      Met Ser Ser Pro Ser Leu Ser Asp Leu Gly Lys Arg Glu Pro Ala
        1               5                  10                  15

 gtc gcc gcg gac gag cgg ggc acg cag cag cgc cgg gcc tac gcc aac      156
 Val Ala Ala Asp Glu Arg Gly Thr Gln Gln Arg Arg Ala Tyr Ala Asn
                  20                  25                  30

 gcc acc tgg aac agc atc cac aac ggg gtg atc gcc gtc ttc cag cgc      204
 Ala Thr Trp Asn Ser Ile His Asn Gly Val Ile Ala Val Phe Gln Arg
              35                  40                  45

 aag ggg ctg ccc gac cag gag ctc ttc agc ctc aac gag ggc gtc cgg      252
 Lys Gly Leu Pro Asp Gln Glu Leu Phe Ser Leu Asn Glu Gly Val Arg
          50                  55                  60

 cag ctg ttg aag aca gag ctg ggg tcc ttc ttc acg gag tac ctg cag      300
 Gln Leu Leu Lys Thr Glu Leu Gly Ser Phe Phe Thr Glu Tyr Leu Gln
      65                  70                  75

 aac cag ctg ctg aca aaa ggc atg gtg atc ctt cgg gac aag att cgc      348
 Asn Gln Leu Leu Thr Lys Gly Met Val Ile Leu Arg Asp Lys Ile Arg
  80                  85                  90                  95

 ttc tat gag gag ctg cag aga gac aag gcg gcg gcg gct gct gtg ctg      396
 Phe Tyr Glu Glu Leu Gln Arg Asp Lys Ala Ala Ala Ala Ala Val Leu
                 100                 105                 110

 ggt gca gtg agg aag agg ccc tcg gtg gtg ccc atg gct ggc cag gat      444
 Gly Ala Val Arg Lys Arg Pro Ser Val Val Pro Met Ala Gly Gln Asp
             115                 120                 125

 cct gcg ctg agc acg agt cac ccg ttc tac gac gtg gcc aga cat ggc      492
 Pro Ala Leu Ser Thr Ser His Pro Phe Tyr Asp Val Ala Arg His Gly
         130                 135                 140

 att ctg cag gtg gca ggg gat gac cgc ttt gga aga cgt gtt gtc acg      540
 Ile Leu Gln Val Ala Gly Asp Asp Arg Phe Gly Arg Arg Val Val Thr
     145                 150                 155

 ttc agc tgc tgc cgg atg ccg ccc tcc cac gag ctg gac cac cag cgg      588
 Phe Ser Cys Cys Arg Met Pro Pro Ser His Glu Leu Asp His Gln Arg
 160                 165                 170                 175

 ctg ctg gag tat ttg aag tac aca ctg gac caa tac gtt gag aac gat      636
 Leu Leu Glu Tyr Leu Lys Tyr Thr Leu Asp Gln Tyr Val Glu Asn Asp
                 180                 185                 190

 tat acc atc gtc tat ttc cac tac ggg ctg aac agc cgg aac aag cct      684
 Tyr Thr Ile Val Tyr Phe His Tyr Gly Leu Asn Ser Arg Asn Lys Pro
             195                 200                 205

 tcc ctg ggc tgg ctc cag agc gca tac aag gag ttc gat agg aag tac      732
 Ser Leu Gly Trp Leu Gln Ser Ala Tyr Lys Glu Phe Asp Arg Lys Tyr
         210                 215                 220

 aag aag aac ttg aag gcc ctc tac gtg gtg cac ccc acc agc ttc atc      780
 Lys Lys Asn Leu Lys Ala Leu Tyr Val Val His Pro Thr Ser Phe Ile
     225                 230                 235

 aag gtc ctg tgg aac atc ttg aag ccc ctc atc agt cac aag ttt ggg      828
 Lys Val Leu Trp Asn Ile Leu Lys Pro Leu Ile Ser His Lys Phe Gly
 240                 245                 250                 255

 aag aaa gtc atc tat ttc aac tac ctg agt gag ctc cac gaa cac ctt      876
 Lys Lys Val Ile Tyr Phe Asn Tyr Leu Ser Glu Leu His Glu His Leu
                 260                 265                 270

 aaa tac gac cag ctg gtc atc cct ccc gaa gtt ttg cgg tac gat gag      924
 Lys Tyr Asp Gln Leu Val Ile Pro Pro Glu Val Leu Arg Tyr Asp Glu
             275                 280                 285

 aag ctc cag agc ctg cac gag ggc cgg acg ccg cct ccc acc aag aca      972
 Lys Leu Gln Ser Leu His Glu Gly Arg Thr Pro Pro Pro Thr Lys Thr
         290                 295                 300

 cca ccg ccg cgg ccc ccg ctg ccc aca cag cag ttt ggc gtc agt ctg     1020
 Pro Pro Pro Arg Pro Pro Leu Pro Thr Gln Gln Phe Gly Val Ser Leu
     305                 310                 315

 caa tac ctc aaa gac aaa aat caa ggc gaa ctc atc ccc cct gtg ctg     1068
 Gln Tyr Leu Lys Asp Lys Asn Gln Gly Glu Leu Ile Pro Pro Val Leu
 320                 325                 330                 335

 agg ttc aca gtg acg tac ctg aga gag aaa ggc ctg cgc acc gag ggc     1116
 Arg Phe Thr Val Thr Tyr Leu Arg Glu Lys Gly Leu Arg Thr Glu Gly
                 340                 345                 350

 ctg ttc cgg aga tcc gcc agc gtg cag acc gtc cgc gag atc cag agg     1164
 Leu Phe Arg Arg Ser Ala Ser Val Gln Thr Val Arg Glu Ile Gln Arg
             355                 360                 365

 ctc tac aac caa ggg aag ccc gtg aac ttt gac gac tac ggg gac att     1212
 Leu Tyr Asn Gln Gly Lys Pro Val Asn Phe Asp Asp Tyr Gly Asp Ile
         370                 375                 380

 cac atc cct gcc gtg atc ctg aag acc ttc ctg cga gag ctg ccc cag     1260
 His Ile Pro Ala Val Ile Leu Lys Thr Phe Leu Arg Glu Leu Pro Gln
     385                 390                 395

 ccg ctt ctg acc ttc cag gcc tac gag cag att ctt ggg atc acc tgt     1308
 Pro Leu Leu Thr Phe Gln Ala Tyr Glu Gln Ile Leu Gly Ile Thr Cys
 400                 405                 410                 415

 gtg gag agc agc ctg cgt gtc act ggc tgc cgc cag atc tta cgg agc     1356
 Val Glu Ser Ser Leu Arg Val Thr Gly Cys Arg Gln Ile Leu Arg Ser
                 420                 425                 430

 ctc cca gag cac aac tac gtc gtc ctc cgc tac ctc atg ggc ttc ctg     1404
 Leu Pro Glu His Asn Tyr Val Val Leu Arg Tyr Leu Met Gly Phe Leu
             435                 440                 445

 cat gcg gtg tcc cgg gag agc atc ttc aac aaa atg aac agc tct aac     1452
 His Ala Val Ser Arg Glu Ser Ile Phe Asn Lys Met Asn Ser Ser Asn
         450                 455                 460

 ctg gcc tgt gtc ttc ggg ctg aat ttg atc tgg cca tcc cag ggg gtc     1500
 Leu Ala Cys Val Phe Gly Leu Asn Leu Ile Trp Pro Ser Gln Gly Val
     465                 470                 475

 tcc tcc ctg agt gcc ctt gtg ccc ctg aac atg ttc act gaa ctg ctg     1548
 Ser Ser Leu Ser Ala Leu Val Pro Leu Asn Met Phe Thr Glu Leu Leu
 480                 485                 490                 495

 atc gag tac tat gaa aag atc ttc agc acc ccg gag gca cct ggg gag     1596
 Ile Glu Tyr Tyr Glu Lys Ile Phe Ser Thr Pro Glu Ala Pro Gly Glu
                 500                 505                 510

 cac ggc ctg gca cca tgg gaa cag ggg agc agg gca gcc cct ttg cag     1644
 His Gly Leu Ala Pro Trp Glu Gln Gly Ser Arg Ala Ala Pro Leu Gln
             515                 520                 525

 gag gct gtg cca cgg aca caa gcc acg ggc ctc acc aag cct acc cta     1692
 Glu Ala Val Pro Arg Thr Gln Ala Thr Gly Leu Thr Lys Pro Thr Leu
         530                 535                 540

 cct ccg agt ccc ctg atg gca gcc aga aga cgt ctc tagt gttgcgaaca     1742
 Pro Pro Ser Pro Leu Met Ala Ala Arg Arg Arg Leu 
     545                 550                 555

 ctctgtatgt ttcgagctac ctcccacacc tgtctgtgca cttgtatgtt ttataaactt   1802

 ggcatctgta aaaataacca gccattagat gaattcagaa ccttctaatg aaaaaaaaaa   1862

 aaa                                                                 1865




      <210> 191
      <211> 1092
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (556)..(972)

      <400> 191
 gaagttccaa catgctttat ttgaggacga gcgctcaccc gggatggagt aagaagtggg     60

 atgggagaag cgtagggttc aaattttctt tgtgtctctg tgatccttaa agcatctcag    120

 caagctgtag agatggtatt aaggggagag aaaactttga gatgacaaga ggaaacgtta    180

 ataccattct cactccaatg aaacccatga ccacttttta aatgtcctac agagtcactg    240

 ggtgagataa gtaagatcac tgtttcaata cagatgggga aagataataa ataaagaagt    300

 cttggttttc ttcatttgca gggaggatta ccagggtaga aatgggtaaa aatcggtaaa    360

 taactattta ctactgtctc tggtgttttc tcataatcaa gccacttaaa tacctcccta    420

 cttttccctc aactcccaga acaaagccaa gactttgata ccaatttctt cgtgcttttc    480

 ctcaagcagg taactaggag tatccctact ccagccttgt gcccctagaa ctgggctgga    540

 gctcagagac ttaaa atg act cat ggc agc tgc ctt ccc cag ctc agt gat     591
                  Met Thr His Gly Ser Cys Leu Pro Gln Leu Ser Asp
                    1               5                  10

 aag gtc gcc cct gcc aaa cac tgg aga cca aag ccc agg tcc atc act      639
 Lys Val Ala Pro Ala Lys His Trp Arg Pro Lys Pro Arg Ser Ile Thr
          15                  20                  25

 ccc ata gtg act cct ccc ata agc tct gcc tca gct gtg aaa ggc aag      687
 Pro Ile Val Thr Pro Pro Ile Ser Ser Ala Ser Ala Val Lys Gly Lys
      30                  35                  40

 agg gag aag ggg agt gag gct ctt gtt cct cct cac cta gtg gga aga      735
 Arg Glu Lys Gly Ser Glu Ala Leu Val Pro Pro His Leu Val Gly Arg
  45                  50                  55                  60

 tat gcc tct tca agg tcc cac ccc agc cag gga gga gag ggc agg cct      783
 Tyr Ala Ser Ser Arg Ser His Pro Ser Gln Gly Gly Glu Gly Arg Pro
                  65                  70                  75

 cag gca ggg tgt gga cac agc tgg ttg aca ctc agc tca gct aca gat      831
 Gln Ala Gly Cys Gly His Ser Trp Leu Thr Leu Ser Ser Ala Thr Asp
              80                  85                  90

 cgg ctc agc cac agt tgg gcc ggc ctg aac ccc agg tgc cca cca gca      879
 Arg Leu Ser His Ser Trp Ala Gly Leu Asn Pro Arg Cys Pro Pro Ala
          95                 100                 105

 gca act tgg ccc cct tgc tct acc ttc tca cca ttc gcc agc agt ggg      927
 Ala Thr Trp Pro Pro Cys Ser Thr Phe Ser Pro Phe Ala Ser Ser Gly
     110                 115                 120

 tgc agg cag cca tca tct ttc cac aaa gat gtt cag ttg gag gaa tga      975
 Cys Arg Gln Pro Ser Ser Phe His Lys Asp Val Gln Leu Glu Glu 
 125                 130                 135

 gaggagccac caaatgaaaa aggtacaggt tgagcgtcct taacccaaag atccaaaatc   1035

 aaaaatgctc cataacccaa aacttttttt tttttgagtt gggttctccc agtggcg      1092




      <210> 192
      <211> 620
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (27)..(389)

      <400> 192
 tgggagcaga tctctgcaga ataaaa atg aaa aag cat ctg acg acc ttc ttg      53
                              Met Lys Lys His Leu Thr Thr Phe Leu
                                1               5

 gtg att ttg tgg ctt tat ttt tat agg ggg aat ggc aaa aac caa gtg      101
 Val Ile Leu Trp Leu Tyr Phe Tyr Arg Gly Asn Gly Lys Asn Gln Val
  10                  15                  20                  25

 gag cag agt cct cag tcc ctg atc atc ctg gag gga aag aac tgc act      149
 Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly Lys Asn Cys Thr
                  30                  35                  40

 ctt caa tgc aat tat aca gtg agc ccc ttc agc aac tta agg tgg tat      197
 Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn Leu Arg Trp Tyr
              45                  50                  55

 aag caa gat act ggg aga ggt cct gtt tcc ctg aca atc atg act ttc      245
 Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr Ile Met Thr Phe
          60                  65                  70

 agt gag aac aca aag tcg aac gga aga tat aca gca act ctg gat gca      293
 Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala Thr Leu Asp Ala
      75                  80                  85

 gac aca aag caa agc tct ctg cac atc aca gcc tcc cag ctc agc gat      341
 Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser Gln Leu Ser Asp
  90                  95                 100                 105

 tca gcc tcc tac atc tgt gtg gtg agc gca ctg tgc tcc aca ggc act      389
 Ser Ala Ser Tyr Ile Cys Val Val Ser Ala Leu Cys Ser Thr Gly Thr 
                 110                 115                 120

 tgaagccagt atgcaaacct gcacctggag gttatcaagg aggcatagga gttagagtag    449

 accgttattt tttatgcaga atatgatttc actagtgaat atttatctct ccgacatgat    509

 ttgatttgag cttgagccta aagttctact taggctcaag tagaatacat gtcctcaagc    569

 gaggataaag acattctcac tcaacacaca aagttaattg ctacatctgg c             620




      <210> 193
      <211> 350
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (131)..(304)

      <400> 193
 aggttcacaa taaaggtgct aagaaagaga atgtaagaca ggaaaataat taaatattct     60

 taccgagtgt cttcaatagg ccgtgtttaa gaggcgtctt acactccctg ttgccagtgg    120

 ctggaacaca   atg gat cac aca ggg gcg ata gac acc gag gat gaa gtg     169
              Met Asp His Thr Gly Ala Ile Asp Thr Glu Asp Glu Val
                1               5                  10

 gga cct tta gcc cat ctt gct cca agt cct cag agt gaa gct gtg gct      217
 Gly Pro Leu Ala His Leu Ala Pro Ser Pro Gln Ser Glu Ala Val Ala
      15                  20                  25

 cat gaa ttc cag gaa ctc tcc ttg cag tcc agt caa aac tta ccc cct      265
 His Glu Phe Gln Glu Leu Ser Leu Gln Ser Ser Gln Asn Leu Pro Pro
  30                  35                  40                  45

 ctg aac gaa agg aaa aat gtg aac att cct cca tgt tat taaatgttcc       314
 Leu Asn Glu Arg Lys Asn Val Asn Ile Pro Pro Cys Tyr 
                  50                  55

 tctcagctgg gcatgatggc tcacacctgt aatccc                              350




      <210> 194
      <211> 1363
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (685)..(948)

      <400> 194
 gcattattta aaaaacctct aaaattagga aaagaattcc cacatgtggt ttttaatata     60

 tctcatgcta cttcgaaata taatctgcac tagtctttgt taaagtttga gggagtcata    120

 aaataatgtc cctctcctct cctgacctct gaaccacttg agacacagac agatggagat    180

 tcaatatttt aagtttactg ctgaaaaagg ctaggttaga ggatgtactt taagtttatg    240

 ccaacaatag ccaccagata ttgaacttag aattagacag acctgcttac taaggcatgg    300

 gcagttctgc acaagcacaa atctcccttt gcagaggcaa agaactttca ctgcaaggtt    360

 cacaatgtag ctggcaagag accacaacat cggttctctg cagttatgac aaatccacaa    420

 aagggaaaaa agaggctagc atgcccagtt ctatatctta aactccctcc tttcctggtg    480

 aagtgagaga aagagattag aattccttgg taaatggata gcctaagaag cactgtgaga    540

 ggaagccatc cttacccgcc gctgccttct gaccaaagta gttcatatat agtgcacatt    600

 agggcatgat tcatgttaca gtagctttag ggccacactt cttcttccga agtaaccata    660

 tttaattgca agtgactaag gtaa   atg act tta ggg ata acc tcc ttt att     711
                              Met Thr Leu Gly Ile Thr Ser Phe Ile
                                1               5

 tca ttt tat ttc tgt ttt ata att tat ata ttt caa tat ctt att att      759
 Ser Phe Tyr Phe Cys Phe Ile Ile Tyr Ile Phe Gln Tyr Leu Ile Ile
  10                  15                  20                  25

 ggt aag aaa aac tta act ttc tca gtc cta aaa ttc ttt att atc aaa      807
 Gly Lys Lys Asn Leu Thr Phe Ser Val Leu Lys Phe Phe Ile Ile Lys
                  30                  35                  40

 tac atc agt tta ata ata atc tct aag gaa gaa aaa aac aca ttt aag      855
 Tyr Ile Ser Leu Ile Ile Ile Ser Lys Glu Glu Lys Asn Thr Phe Lys
              45                  50                  55

 ata tcc att gat ttg aag ata att att atg gaa cta tgg ttc tta tgt      903
 Ile Ser Ile Asp Leu Lys Ile Ile Ile Met Glu Leu Trp Phe Leu Cys
          60                  65                  70

 caa ctc aca act cat tta gat att aat aca tgt atc atg aaa tca tag      951
 Gln Leu Thr Thr His Leu Asp Ile Asn Thr Cys Ile Met Lys Ser 
      75                  80                  85

 ctcagaattg ctggtccaga gtcactttag aatggctctg attcaaggaa attaaaagaa   1011

 atgattgtta attttcttag tgctgggaaa ggcagtgaaa caagcttttg aatcattatg   1071

 taattttcaa acaactaaaa gggctatact gttcagttat aatcttaaaa attctagctg   1131

 agacagagct tttaaaaaat ctttatagtt ttaccatacg gcatcaattc aaaagattgt   1191

 catactgaaa ccactgccat aaaattttgt atgtaggccc cagttgcagt agatctggct   1251

 cctgtgagct ataacttgca tggcttttca atgtttatgt agtgtctgtt aatatattta   1311

 agataaatac tctataacca aacagcctgt tttctagaga atgatatatg at           1363




      <210> 195
      <211> 806
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (52)..(660)

      <400> 195
 gcttgaaaat actttccaag atgaaaattc atcagggtgg gtataattct g atg aaa      57
                                                          Met Lys
                                                            1

 acg cct gtg ttc atc aac aca ggg tca gag cgc tca ccg ggt cga tgt      105
 Thr Pro Val Phe Ile Asn Thr Gly Ser Glu Arg Ser Pro Gly Arg Cys
           5                  10                  15

 gca aat cca agc cag gaa gtc ctg ctc cgg gtg gaa ggt aaa acc ttc      153
 Ala Asn Pro Ser Gln Glu Val Leu Leu Arg Val Glu Gly Lys Thr Phe
      20                  25                  30

 cct cca ggg aac cag ggg ctc cgg cgg gca tcg gag gca gct tct tgg      201
 Pro Pro Gly Asn Gln Gly Leu Arg Arg Ala Ser Glu Ala Ala Ser Trp
  35                  40                  45                  50

 cct ctg ctg ctg tgt ccc cca gtc ccc cca gcc cgc att aat gtc ctc      249
 Pro Leu Leu Leu Cys Pro Pro Val Pro Pro Ala Arg Ile Asn Val Leu
                  55                  60                  65

 tgg aat aag agc ctg tgg ctg aag cag agg gcc ttc tgg gag agc tct      297
 Trp Asn Lys Ser Leu Trp Leu Lys Gln Arg Ala Phe Trp Glu Ser Ser
              70                  75                  80

 cca agg tct gga agg agg gtc ccc cag aag gag ctc cgg ggt agc ccc      345
 Pro Arg Ser Gly Arg Arg Val Pro Gln Lys Glu Leu Arg Gly Ser Pro
          85                  90                  95

 act gtg gcc ccc ctg gac tcc acc agc ttc atg ctt ctc aga tgc tac      393
 Thr Val Ala Pro Leu Asp Ser Thr Ser Phe Met Leu Leu Arg Cys Tyr
     100                 105                 110

 cca ggg gcc ggc ccg ggg aga cca ggg cag att tct ccc gca cca ggc      441
 Pro Gly Ala Gly Pro Gly Arg Pro Gly Gln Ile Ser Pro Ala Pro Gly
 115                 120                 125                 130

 tgt gga ggt ttg gag ggc tgc ctg agc aga cac tgt gcc att gct ggg      489
 Cys Gly Gly Leu Glu Gly Cys Leu Ser Arg His Cys Ala Ile Ala Gly
                 135                 140                 145

 gct ggg gaa aga ata tct gag acg acg ttt ggg agc aat gct ctt tac      537
 Ala Gly Glu Arg Ile Ser Glu Thr Thr Phe Gly Ser Asn Ala Leu Tyr
             150                 155                 160

 cac gtt cac caa atc gtc tgg ggc agg ggt tgt gag ctg cag cag ttg      585
 His Val His Gln Ile Val Trp Gly Arg Gly Cys Glu Leu Gln Gln Leu
         165                 170                 175

 ctg gtg cct tgt ggg aag gtg ggg cag gga gga ggc tgc ccg cca cct      633
 Leu Val Pro Cys Gly Lys Val Gly Gln Gly Gly Gly Cys Pro Pro Pro
     180                 185                 190

 ctg ccc cca gtc act tcc tgc ttg acc tgact cttcacatgt ggctgcttaa      685
 Leu Pro Pro Val Thr Ser Cys Leu Thr 
 195                 200

 ttcctgcccc tctcccccca gctgcttctc ctttactaac acacctgcta cattttacac    745

 atgtgttggt aagtgagaaa cagaaacgaa aaataaatta aaatgcagaa aaaaaaaaaa    805

 a                                                                    806




      <210> 196
      <211> 1885
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (120)..(1061)

      <400> 196
 aggaaaactc agggcgaggt gagagaggac agaacctcta accaggaaga ggctgtcccc     60

 gccaagctcc ggagaggcgc ggaagcatga ccctcaggtg gtaacagaaa acaatccag     119                                                                 
 atg ggg tgc agg tgc tgt aaa ata ata caa agc tat ctc ttt gat cca      167
 Met Gly Cys Arg Cys Cys Lys Ile Ile Gln Ser Tyr Leu Phe Asp Pro
   1               5                  10                  15

 gtt caa gtg ccc tct cct ggc tat gtc aat gaa gtc aac agc tgc aag      215
 Val Gln Val Pro Ser Pro Gly Tyr Val Asn Glu Val Asn Ser Cys Lys
              20                  25                  30

 cta gat gaa gac gac act gat aaa tta aaa ggc aaa tgg agc agt gaa      263
 Leu Asp Glu Asp Asp Thr Asp Lys Leu Lys Gly Lys Trp Ser Ser Glu
          35                  40                  45

 gtc ttg gtg cag aaa aat gac cct cag agg cag ggc tca aag aag act      311
 Val Leu Val Gln Lys Asn Asp Pro Gln Arg Gln Gly Ser Lys Lys Thr
      50                  55                  60

 gag agc agc agc agg aca gct gat cca tgg gag ccc tgc tgg cct cac      359
 Glu Ser Ser Ser Arg Thr Ala Asp Pro Trp Glu Pro Cys Trp Pro His
  65                  70                  75                  80

 caa ggg ccg ctc cca cag ggg gac gct gga ggg gaa cac cat gcc tgc      407
 Gln Gly Pro Leu Pro Gln Gly Asp Ala Gly Gly Glu His His Ala Cys
                  85                  90                  95

 ggt gtc aac ggc atc ggc cct gct gcc act cca cag ccc act ggg aat      455
 Gly Val Asn Gly Ile Gly Pro Ala Ala Thr Pro Gln Pro Thr Gly Asn
             100                 105                 110

 tcc agc ccc acc cag gat gac agg ggc tcc tgg gcc agt act gca aat      503
 Ser Ser Pro Thr Gln Asp Asp Arg Gly Ser Trp Ala Ser Thr Ala Asn
         115                 120                 125

 act gtt ccc cca act caa ccc ttc ctg gaa gga ggg ggc acc agg aaa      551
 Thr Val Pro Pro Thr Gln Pro Phe Leu Glu Gly Gly Gly Thr Arg Lys
     130                 135                 140

 cag gac tgt gtg ctg ctg gcc tca gaa ggg acc caa gtc atg aga aat      599
 Gln Asp Cys Val Leu Leu Ala Ser Glu Gly Thr Gln Val Met Arg Asn
 145                 150                 155                 160

 gga gac tcc aga gct cct tct gag gca gaa agt ttt gcc ttg gaa gta      647
 Gly Asp Ser Arg Ala Pro Ser Glu Ala Glu Ser Phe Ala Leu Glu Val
                 165                 170                 175

 caa gac cat gtc ttc cag ata cca gcc cca gat tac ctt cag cat tgg      695
 Gln Asp His Val Phe Gln Ile Pro Ala Pro Asp Tyr Leu Gln His Trp
             180                 185                 190

 ggc cca gct gga gac aac gtt gat cat aat gaa aag gac tgt gtt ttc      743
 Gly Pro Ala Gly Asp Asn Val Asp His Asn Glu Lys Asp Cys Val Phe
         195                 200                 205

 aag aac cat act gag gat gaa tcc cta gag gga att cag ccc cca gtg      791
 Lys Asn His Thr Glu Asp Glu Ser Leu Glu Gly Ile Gln Pro Pro Val
     210                 215                 220

 ggg gag cat ggt ttg aat acg ccc ttc tct gtg agg aga agc tgg gat      839
 Gly Glu His Gly Leu Asn Thr Pro Phe Ser Val Arg Arg Ser Trp Asp
 225                 230                 235                 240

 tca ttg aat gag gat gtg gaa aca gaa gtt cta agc atc tgc ttt aat      887
 Ser Leu Asn Glu Asp Val Glu Thr Glu Val Leu Ser Ile Cys Phe Asn
                 245                 250                 255

 gag aag ggt cct gtt cat gcc atg cct gtg gtt gac tca gga aac agg      935
 Glu Lys Gly Pro Val His Ala Met Pro Val Val Asp Ser Gly Asn Arg
             260                 265                 270

 cag gag gat acc cat ggc tcc gat gga gat ggg gat ggg gag att gtg      983
 Gln Glu Asp Thr His Gly Ser Asp Gly Asp Gly Asp Gly Glu Ile Val
         275                 280                 285

 gac gag gat gca gcg gtg gcg gag gcc ctt gca gct tta gaa gct gct     1031
 Asp Glu Asp Ala Ala Val Ala Glu Ala Leu Ala Ala Leu Glu Ala Ala
     290                 295                 300

 act gca gga gaa gat ttg gat gag act gat t aggggagggg atttgcacag     1082
 Thr Ala Gly Glu Asp Leu Asp Glu Thr Asp 
 305                 310

 ggaggtaagc tggtgtcatg ctgagcatgc agatgcattt gctccctgga tgcatagcag   1142

 gtgattctgc cagcatgcac cagtgcagcc ttaccagttg tttacatcca gcatctgttc   1202

 tgattgtcag catctgtccc atgctgcttg tcacatatct ggagtttcac tctgtgtaga   1262

 tgagctgtca ttcaggacac taggagaaaa atctgagtgg gtcattgtgc ccatatccac   1322

 agaaaatgca gaagttgaac agcttgcttg acaaccctca aacatctttg agcacctggt   1382

 acagatgttt atgagaatac tctaagatct caacccttga tcccaaaggc acacaatcac   1442

 agagcattcc ttttgactgt aaactgttta ccttgctttt gagagccaaa cattgtaccc   1502

 aacctggaaa aagtaactac cccaattaaa gtgcctcatg tgtccccaga gcatggctta   1562

 acttcaggga caatcaccca gggaactaat aactaaccag ttgttcaaca gcgggttaag   1622

 ctcagcagtt ttcacagtag agcagaagtc cccaggaaac aaagggttag tcattagctg   1682

 agatgttgat tttaaaacac cttgacctta acttttttac attattactt ttaaatctcc   1742

 tttgggattg gggaggctgg ccaaaataag tcttaaaact gcttatgtca tatttggatt   1802

 ttaagttcat gacattcgga acagcaaagc catatatgca atgtttttat gccattaaat   1862

 gtctgattcc aattaaaata aaa                                           1885




      <210> 197
      <211> 2897
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (226)..(1542)

      <400> 197
 aaggtccaat cccatgatca taattggggg cgcgtggagg gatactcttt agcggccgcg     60

 ggatgcccct gcgctgaccg ccaggggcag gtgcccgccc gcgtagacgc acccggcctg    120

 accccgcgcc accatgtaaa cggcgccagc aggcggacgc tggcttctcc gcctgggacc    180

 cctccgcccc gacccgggcc ccgcggccct cgatgaggac acacc    atg ctg acc     234
                                                      Met Leu Thr
                                                        1

 ggg gtg acc gac ggt atc ttc tgt tgc ctg ctg ggc acg ccc ccc aac      282
 Gly Val Thr Asp Gly Ile Phe Cys Cys Leu Leu Gly Thr Pro Pro Asn
       5                  10                  15

 gcc gtg ggg cca ctg gag agc gtc gag tcc agc gat ggc tac acc ttt      330
 Ala Val Gly Pro Leu Glu Ser Val Glu Ser Ser Asp Gly Tyr Thr Phe
  20                  25                  30                  35

 gta gag gtc aag ccc ggc cgc gtg ctg cgg gtg aag cat gca gga ccc      378
 Val Glu Val Lys Pro Gly Arg Val Leu Arg Val Lys His Ala Gly Pro
                  40                  45                  50

 gcc cca gcc gct gcc cca cct cca cca tca tcc gca tcc tcg gat gca      426
 Ala Pro Ala Ala Ala Pro Pro Pro Pro Ser Ser Ala Ser Ser Asp Ala
              55                  60                  65

 gcc cag ggg gac ctc tcc ggc ttg gtc cgc tgt cag cgc cgg atc acc      474
 Ala Gln Gly Asp Leu Ser Gly Leu Val Arg Cys Gln Arg Arg Ile Thr
          70                  75                  80

 gtg tac cgc aat ggg cgg ttg ctg gtg gaa aac ctg ggc cga gcc cct      522
 Val Tyr Arg Asn Gly Arg Leu Leu Val Glu Asn Leu Gly Arg Ala Pro
      85                  90                  95

 cga gcc gac ctc cta cac ggg cag aat ggc tct ggg gag ccg ccg gcc      570
 Arg Ala Asp Leu Leu His Gly Gln Asn Gly Ser Gly Glu Pro Pro Ala
 100                 105                 110                 115

 gcc ctg gag gtg gag ctg gca gat ccg gcg ggc agc gat ggc cgc ttg      618
 Ala Leu Glu Val Glu Leu Ala Asp Pro Ala Gly Ser Asp Gly Arg Leu
                 120                 125                 130

 gcc ccc ggc agc gca ggc agc ggc agc ggc agt ggc agt ggt ggg cgg      666
 Ala Pro Gly Ser Ala Gly Ser Gly Ser Gly Ser Gly Ser Gly Gly Arg
             135                 140                 145

 cgg cgg cga gcc agg cgc ccc aag agg acc atc cat att gac tgt gag      714
 Arg Arg Arg Ala Arg Arg Pro Lys Arg Thr Ile His Ile Asp Cys Glu
         150                 155                 160

 aag cgc atc act agc tgc aaa ggc gcc cag gcc gac gtg gtg ctc ttt      762
 Lys Arg Ile Thr Ser Cys Lys Gly Ala Gln Ala Asp Val Val Leu Phe
     165                 170                 175

 ttc atc cat ggt gtc ggc ggt tcc ctg gcc atc tgg aag gag cag ctg      810
 Phe Ile His Gly Val Gly Gly Ser Leu Ala Ile Trp Lys Glu Gln Leu
 180                 185                 190                 195

 gac ttc ttt gtg cgc cta ggc tat gag gtg gtg gct cct gac ctg gcc      858
 Asp Phe Phe Val Arg Leu Gly Tyr Glu Val Val Ala Pro Asp Leu Ala
                 200                 205                 210

 ggc cac ggg gcc agc tct gcg ccc cag gtg gcc gca gcc tac acc ttc      906
 Gly His Gly Ala Ser Ser Ala Pro Gln Val Ala Ala Ala Tyr Thr Phe
             215                 220                 225

 tat gcg ctg gct gag gac atg cga gca atc ttc aag cgc tat gcc aag      954
 Tyr Ala Leu Ala Glu Asp Met Arg Ala Ile Phe Lys Arg Tyr Ala Lys
         230                 235                 240

 aag cga aat gtg ctc att ggc cat tcc tac ggt gtc tct ttc tgc aca     1002
 Lys Arg Asn Val Leu Ile Gly His Ser Tyr Gly Val Ser Phe Cys Thr
     245                 250                 255

 ttc ctg gca cat gag tac cca gac cta gtg cac aag gtg atc atg atc     1050
 Phe Leu Ala His Glu Tyr Pro Asp Leu Val His Lys Val Ile Met Ile
 260                 265                 270                 275

 aat ggc ggg ggc cct acg gcg ctg gag ccc agc ttc tgc tca atc ttc     1098
 Asn Gly Gly Gly Pro Thr Ala Leu Glu Pro Ser Phe Cys Ser Ile Phe
                 280                 285                 290

 aac atg ccc acc tgc gtc ctg cac tgc ttg tcg ccc tgc ctg gcc tgg     1146
 Asn Met Pro Thr Cys Val Leu His Cys Leu Ser Pro Cys Leu Ala Trp
             295                 300                 305

 agc ttc ctc aag gcc ggc ttc gcc cgc caa gga gcc aag gag aag cag     1194
 Ser Phe Leu Lys Ala Gly Phe Ala Arg Gln Gly Ala Lys Glu Lys Gln
         310                 315                 320

 ctg tta aag gag ggc aac gct ttc aac gtg tca tcc ttc gta ctc cgg     1242
 Leu Leu Lys Glu Gly Asn Ala Phe Asn Val Ser Ser Phe Val Leu Arg
     325                 330                 335

 gcc atg atg agc ggc cag tac tgg ccc gag ggc gac gag gtc tac cac     1290
 Ala Met Met Ser Gly Gln Tyr Trp Pro Glu Gly Asp Glu Val Tyr His
 340                 345                 350                 355

 gcc gag ctc acc gtg ccc gtc ctg ctt gtc cac ggc atg cac gat aag     1338
 Ala Glu Leu Thr Val Pro Val Leu Leu Val His Gly Met His Asp Lys
                 360                 365                 370

 ttt gtg ccg gtg gag gaa gac cag cgc atg gcc gag atc ctg ctc ctg     1386
 Phe Val Pro Val Glu Glu Asp Gln Arg Met Ala Glu Ile Leu Leu Leu
             375                 380                 385

 gca ttc ctg aag ctc atc gac gag ggc agc cac atg gtg atg ctg gaa     1434
 Ala Phe Leu Lys Leu Ile Asp Glu Gly Ser His Met Val Met Leu Glu
         390                 395                 400

 tgc cct gag acg gtc aac acg ctg ctc cac gaa ttc ctg ctc tgg gag     1482
 Cys Pro Glu Thr Val Asn Thr Leu Leu His Glu Phe Leu Leu Trp Glu
     405                 410                 415

 ccc gag ccc tcg ccc aat ggc tct acc tgg atg cca cat gac acg gct     1530
 Pro Glu Pro Ser Pro Asn Gly Ser Thr Trp Met Pro His Asp Thr Ala
 420                 425                 430                 435

 gcc tac cag gaa tga caatgaaagt atgacctgct tgtgtgcctg tgcgtgtggc     1585
 Ala Tyr Gln Glu 


 aatctgctat gtgttgatgc accatgcctg aaatgaccac ggacgtgatg gccctgaagc   1645

 cttgacagcc aatggtgtct tgcaatgtct gcaaagaacc caacctttgt gggactgtgg   1705

 cacatggttt acagaatacc atgtgattgg tggactggtg tgaggccaaa cgggtccact   1765

 ggggatgaac ttgacaccac acagtggcat ttgccattgt ggtgacctgg gtgacccgtt   1825

 agaggacaat acctggaaag aatggacgac caacctatat gtctggggaa caagatttac   1885

 accgatgctt tcaatcactg ggacattcat cccgggatca cacctggcta gtgtggagga   1945

 cccaataata ctaggcgtct ggtatatcac ttggggggag tgcccctgac acaaagcacc   2005

 aggaatcgga acccccatat ccacactcgc gcatactgac attggaacca atattgctta   2065

 cacaggaaaa cggcacacac gataccacca tcaaaccaaa ttatcccaca acgacgacac   2125

 aacaagcaca caagcccgga caccgaacaa gtgacacacg ggaacccagc acaaaaaaag   2185

 caacggacaa gagcccaaaa ccaggatgac aacaaaacac cagaaagcac aagagcaact   2245

 cacacaggga gcacgacaca cagagcaaga accaccaaaa aaagtggtcg aacacaccag   2305

 acggaaggcg acacccacaa acccaacacg gcagacactc accgcagcaa accaccacaa   2365

 cgcgcaaaac acaacaccac aaaacaacaa aggagcaggc cagtggcaaa gcacaaaaac   2425

 aaaaacgaaa cgaaaagagg caaaagcgga cacgaccaac aaacagagcg caccagagag   2485

 ccacccacaa ccacggaccc cccgtggacc caccaccgtc aagagcccag agagcaacca   2545

 acacacaaca ccaaaccaga caaccaacac gacgcgacca cacacgcaca cacaaacaaa   2605

 aaaggacgac agcacaacac aacaagagcc gcacgaatcg acaagcgacg ccaaccagag   2665

 cgacgccccg cgccgacgcc accagaagaa agacgcagaa gcacacgggt gacaagacaa   2725

 cacggcagca gcagcaagac ccaccacccg cccacagaca cacgcagacc cagacgaccc   2785

 acgcccacaa cagcacgaca cgaaactcgg gagcactgac cgcaccgcac cacgcggacg   2845

 ccacgaccga gcaccgaaca ccaaacacgc acaaaagacg caccgtcacc ca           2897




      <210> 198
      <211> 1600
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (13)..(1077)

      <400> 198
 ggcacgagga gg    atg tcg gtg aat tac gcg gcg ggg ctg tcg ccg tac      48
                  Met Ser Val Asn Tyr Ala Ala Gly Leu Ser Pro Tyr
                    1               5                  10

 gcg gac aag ggc aag tgc ggc ctc ccg gag atc ttc gac ccc ccg gag       96
 Ala Asp Lys Gly Lys Cys Gly Leu Pro Glu Ile Phe Asp Pro Pro Glu
          15                  20                  25

 gag ctg gag cgg aag gtg tgg gaa ctg gcg agg ctg gtc tgg cag tct      144
 Glu Leu Glu Arg Lys Val Trp Glu Leu Ala Arg Leu Val Trp Gln Ser
      30                  35                  40

 tcc agt gtg gtg ttc cac acg ggt gcc ggc atc agc act gcc tct ggc      192
 Ser Ser Val Val Phe His Thr Gly Ala Gly Ile Ser Thr Ala Ser Gly
  45                  50                  55                  60

 atc ccc gac ttc agg ggt ccc cac gga gtc tgg acc atg gag gag cga      240
 Ile Pro Asp Phe Arg Gly Pro His Gly Val Trp Thr Met Glu Glu Arg
                  65                  70                  75

 ggt ctg gcc ccc aag ttc gac acc acc ttt gag agc gcg cgg ccc acg      288
 Gly Leu Ala Pro Lys Phe Asp Thr Thr Phe Glu Ser Ala Arg Pro Thr
              80                  85                  90

 cag acc cac atg gcg ctg gtg cag ctg gag cgc gtg ggc ctc ctc cgc      336
 Gln Thr His Met Ala Leu Val Gln Leu Glu Arg Val Gly Leu Leu Arg
          95                 100                 105

 ttc ctg gtc agc cag aac gtg gac ggg ctc cat gtg cgc tca ggc ttc      384
 Phe Leu Val Ser Gln Asn Val Asp Gly Leu His Val Arg Ser Gly Phe
     110                 115                 120

 ccc agg gac aaa ctg gca gag ctc cac ggg aac atg ttt gtg gaa gaa      432
 Pro Arg Asp Lys Leu Ala Glu Leu His Gly Asn Met Phe Val Glu Glu
 125                 130                 135                 140

 tgt gcc aag tgt aag acg cag tac gtc cga gac aca gtc gtg ggc acc      480
 Cys Ala Lys Cys Lys Thr Gln Tyr Val Arg Asp Thr Val Val Gly Thr
                 145                 150                 155

 atg ggc ctg aag gcc acg ggc cgg ctc tgc acc gtg gct aag gca agg      528
 Met Gly Leu Lys Ala Thr Gly Arg Leu Cys Thr Val Ala Lys Ala Arg
             160                 165                 170

 ggg ctg cga gcc tgc agg gga gag ctg agg gac acc atc cta gac tgg      576
 Gly Leu Arg Ala Cys Arg Gly Glu Leu Arg Asp Thr Ile Leu Asp Trp
         175                 180                 185

 gag gac tcc ctg ccc gac cgg gac ctg gca ctc gcc gat gag gcc agc      624
 Glu Asp Ser Leu Pro Asp Arg Asp Leu Ala Leu Ala Asp Glu Ala Ser
     190                 195                 200

 agg aac gcc gac ctg tcc atc acg ctg ggt aca tcg ctg cag atc cgg      672
 Arg Asn Ala Asp Leu Ser Ile Thr Leu Gly Thr Ser Leu Gln Ile Arg
 205                 210                 215                 220

 ccc agc ggg aac ctg ccg ctg gct acc aag cgc cgg gga ggc cgc ctg      720
 Pro Ser Gly Asn Leu Pro Leu Ala Thr Lys Arg Arg Gly Gly Arg Leu
                 225                 230                 235

 gtc atc gtc aac ctg cag ccc acc aag cac gac cgc cat gct gac ctc      768
 Val Ile Val Asn Leu Gln Pro Thr Lys His Asp Arg His Ala Asp Leu
             240                 245                 250

 cgc atc cat ggc tac gtt gac gag gtc atg acc cgg ctc atg gag cac      816
 Arg Ile His Gly Tyr Val Asp Glu Val Met Thr Arg Leu Met Glu His
         255                 260                 265

 ctg ggg ctg gag atc ccc gcc tgg gac ggc ccc cgt gtg ctg gag agg      864
 Leu Gly Leu Glu Ile Pro Ala Trp Asp Gly Pro Arg Val Leu Glu Arg
     270                 275                 280

 gcg ctg cca ccc ctg ccc cgc ccg ccc acc ccc aag ctg gag ccc aag      912
 Ala Leu Pro Pro Leu Pro Arg Pro Pro Thr Pro Lys Leu Glu Pro Lys
 285                 290                 295                 300

 gag gaa tct ccc acc cgg atc aac ggc tct atc ccc gcc ggc ccc aag      960
 Glu Glu Ser Pro Thr Arg Ile Asn Gly Ser Ile Pro Ala Gly Pro Lys
                 305                 310                 315

 cag gag ccc tgc gcc cag cac aac ggc tca gag ccc gcc agc ccc aaa     1008
 Gln Glu Pro Cys Ala Gln His Asn Gly Ser Glu Pro Ala Ser Pro Lys
             320                 325                 330

 cgg gag cgg ccc acc agc cct gcc ccc cac aga ccc ccc aaa agg gtg     1056
 Arg Glu Arg Pro Thr Ser Pro Ala Pro His Arg Pro Pro Lys Arg Val
         335                 340                 345

 aag gcc aag gcg gtc ccc agc tg accagggtgc ttggggaggg tggggctttt     1109
 Lys Ala Lys Ala Val Pro Ser 
     350                 355

 tgtagaaact gtggattctt tttctctcgt ggtctcactt tgttacttgt ttctgtcccc   1169

 gggagcctca gggctctgag agctgtgctc caggccaggg gttacacctg ccctccgtgg   1229

 tccctccctg ggctccaggg gcctctggtg cggttccggg aagaagccac accccagagg   1289

 tgacagctga gcccctgcca caccccagcc tctgacttgc tgtgttgtcc agaggtgagg   1349

 ctgggccctc cctggtctcc agcttaaaca ggagtgaact ccctctgtcc ccagggcctc   1409

 ccttctgggc cccctacagc ccaccctacc cctcctccat gggccctgca ggaggggaga   1469

 cccaccttga agtgggggat cagtagaggc ttgcactgcc tttggggctg gagggagacg   1529

 tgggtccacc aggcttctgg aaaagtcctc aatgcaataa aaacaatttc tttcttgcaa   1589

 aaaaaaaaaa a                                                        1600




      <210> 199
      <211> 836
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (24)..(827)

      <400> 199
 cgaagcactg tgtttagatc aag    atg tct ggt aaa gca aat gct tcc aag      50
                              Met Ser Gly Lys Ala Asn Ala Ser Lys
                                1               5

 aaa aac gct caa cag tta aaa aga aat cca aag aga aaa aag gat aat       98
 Lys Asn Ala Gln Gln Leu Lys Arg Asn Pro Lys Arg Lys Lys Asp Asn
  10                  15                  20                  25

 gag gaa gtt gtg ttg tca gag aat aag gtt aga aac aca gtg aaa aaa      146
 Glu Glu Val Val Leu Ser Glu Asn Lys Val Arg Asn Thr Val Lys Lys
                  30                  35                  40

 aat aaa aat cat ctg aaa gat ctg tct tct gaa gga caa aca aag cac      194
 Asn Lys Asn His Leu Lys Asp Leu Ser Ser Glu Gly Gln Thr Lys His
              45                  50                  55

 act aac cta aaa cac gga aag aca gca gcc agc aag aga aaa acc tgg      242
 Thr Asn Leu Lys His Gly Lys Thr Ala Ala Ser Lys Arg Lys Thr Trp
          60                  65                  70

 caa cct ctg tca aag agt acc aga gac cat ttg caa act atg atg gaa      290
 Gln Pro Leu Ser Lys Ser Thr Arg Asp His Leu Gln Thr Met Met Glu
      75                  80                  85

 tca gta ata atg aca att ttg agt aac agt att aaa gaa aaa gaa gaa      338
 Ser Val Ile Met Thr Ile Leu Ser Asn Ser Ile Lys Glu Lys Glu Glu
  90                  95                 100                 105

 ata caa tac cat ctc aac ttc ctg aag aaa aga ttg cta caa cag tgt      386
 Ile Gln Tyr His Leu Asn Phe Leu Lys Lys Arg Leu Leu Gln Gln Cys
                 110                 115                 120

 gaa act ctg aaa gtc cct ccc aaa aag atg gaa gat tta act aat gta      434
 Glu Thr Leu Lys Val Pro Pro Lys Lys Met Glu Asp Leu Thr Asn Val
             125                 130                 135

 tca agt cta ctg aat atg gaa agg gca cga gac aaa gct aat gaa gaa      482
 Ser Ser Leu Leu Asn Met Glu Arg Ala Arg Asp Lys Ala Asn Glu Glu
         140                 145                 150

 ggt ctg gca tta cta cag gaa gaa ata gat aaa atg gta gag acc aca      530
 Gly Leu Ala Leu Leu Gln Glu Glu Ile Asp Lys Met Val Glu Thr Thr
     155                 160                 165

 gag tta atg act ggg aat att cag agc cta aag aac aaa att cag att      578
 Glu Leu Met Thr Gly Asn Ile Gln Ser Leu Lys Asn Lys Ile Gln Ile
 170                 175                 180                 185

 ctg gca agt gag gtg gaa gaa gaa gag gag aga gta aaa cag atg cat      626
 Leu Ala Ser Glu Val Glu Glu Glu Glu Glu Arg Val Lys Gln Met His
                 190                 195                 200

 caa ata aat agt agt gga gta ctc tct ctt ccg gaa ctt tct cag aaa      674
 Gln Ile Asn Ser Ser Gly Val Leu Ser Leu Pro Glu Leu Ser Gln Lys
             205                 210                 215

 act ctc aaa gca ccc aca ctt cag aaa gaa att ttg gcg cta att cca      722
 Thr Leu Lys Ala Pro Thr Leu Gln Lys Glu Ile Leu Ala Leu Ile Pro
         220                 225                 230

 aac cag aat gct ctt cta aag gac ttg gat att ctt cat aat tca tca      770
 Asn Gln Asn Ala Leu Leu Lys Asp Leu Asp Ile Leu His Asn Ser Ser
     235                 240                 245

 cag atg aag agc atg tca acc ttc att gaa gaa gcc tat aag aaa ctg      818
 Gln Met Lys Ser Met Ser Thr Phe Ile Glu Glu Ala Tyr Lys Lys Leu
 250                 255                 260                 265

 gat gca tct taaagagtg                                                836
 Asp Ala Ser 






      <210> 200
      <211> 2162
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (61)..(2016)

      <400> 200
 tctccgcgta caggaggcgg cggcggcttt cagtctccgg cccccgccgg cgagcgcacg     60
                                                                 
 atg cac tgc ctg ggc gcc gag tac ctg gtt tct gca gaa gga gcc cct      108
 Met His Cys Leu Gly Ala Glu Tyr Leu Val Ser Ala Glu Gly Ala Pro
   1               5                  10                  15

 agg caa agg gag tgg cga ccc cag att tat agg aaa tgc aca gat acg      156
 Arg Gln Arg Glu Trp Arg Pro Gln Ile Tyr Arg Lys Cys Thr Asp Thr
              20                  25                  30

 gca tgg tta ttc ctg ttc ttt ctc ttt tgg act ggt ttg gtg ttt atc      204
 Ala Trp Leu Phe Leu Phe Phe Leu Phe Trp Thr Gly Leu Val Phe Ile
          35                  40                  45

 atg ggc tac tcg gtg gtg gct gga gcc gcg gga aga ctc ctc ttt ggc      252
 Met Gly Tyr Ser Val Val Ala Gly Ala Ala Gly Arg Leu Leu Phe Gly
      50                  55                  60

 tat gac agc ttt ggc aac atg tgt ggc aag aag aac tcc ccc gtg gaa      300
 Tyr Asp Ser Phe Gly Asn Met Cys Gly Lys Lys Asn Ser Pro Val Glu
  65                  70                  75                  80

 ggg gcc cct ctt tca ggg cag gac atg acc cta aaa aaa cac gtg ttc      348
 Gly Ala Pro Leu Ser Gly Gln Asp Met Thr Leu Lys Lys His Val Phe
                  85                  90                  95

 ttt atg aat tcc tgc aac ctg gaa gtc aaa ggt acg cag ctc aac cgc      396
 Phe Met Asn Ser Cys Asn Leu Glu Val Lys Gly Thr Gln Leu Asn Arg
             100                 105                 110

 atg gcc ctc tgt gta tcc aac tgc cct gaa gag cag ctt gac tcc ctg      444
 Met Ala Leu Cys Val Ser Asn Cys Pro Glu Glu Gln Leu Asp Ser Leu
         115                 120                 125

 gaa gag gtc cag ttc ttt gca aac acc agt ggg tcc ttc ctg tgt gtt      492
 Glu Glu Val Gln Phe Phe Ala Asn Thr Ser Gly Ser Phe Leu Cys Val
     130                 135                 140

 tat agt ttg aat tcc ttc aac tat acc cac agt cca aaa gca gac tca      540
 Tyr Ser Leu Asn Ser Phe Asn Tyr Thr His Ser Pro Lys Ala Asp Ser
 145                 150                 155                 160

 ctg tgt ccc agg cta cca gtt cct cca agc aag tca ttt ccc tta ttt      588
 Leu Cys Pro Arg Leu Pro Val Pro Pro Ser Lys Ser Phe Pro Leu Phe
                 165                 170                 175

 aac cga tgt gtc cct caa aca cct gag tgc tac tcc cta ttt gca tct      636
 Asn Arg Cys Val Pro Gln Thr Pro Glu Cys Tyr Ser Leu Phe Ala Ser
             180                 185                 190

 gtt ttg ata aat gat gtt gac acc ctc cac cga att cta agt gga atc      684
 Val Leu Ile Asn Asp Val Asp Thr Leu His Arg Ile Leu Ser Gly Ile
         195                 200                 205

 atg tcg gga aga gat aca atc ctt ggc ctg tgt atc ctc gca tta gcc      732
 Met Ser Gly Arg Asp Thr Ile Leu Gly Leu Cys Ile Leu Ala Leu Ala
     210                 215                 220

 ttg tct ttg gcc atg atg ttt acc ttc aga ttc atc acc acc ctt ctg      780
 Leu Ser Leu Ala Met Met Phe Thr Phe Arg Phe Ile Thr Thr Leu Leu
 225                 230                 235                 240

 gtt cac att ttc att tca ttg gtt att ttg gga ttg ttg ttt gtc tgc      828
 Val His Ile Phe Ile Ser Leu Val Ile Leu Gly Leu Leu Phe Val Cys
                 245                 250                 255

 ggt gtt tta tgg tgg ctg tat tat gac tat acc aac gac ctc agc ata      876
 Gly Val Leu Trp Trp Leu Tyr Tyr Asp Tyr Thr Asn Asp Leu Ser Ile
             260                 265                 270

 gaa ttg gac aca gaa agg gaa aat atg aag tgc gtg ctg ggg ttt gct      924
 Glu Leu Asp Thr Glu Arg Glu Asn Met Lys Cys Val Leu Gly Phe Ala
         275                 280                 285

 atc gta tcc aca ggc atc acg gca gtg ctg ctc gtc ttg att ttt gtt      972
 Ile Val Ser Thr Gly Ile Thr Ala Val Leu Leu Val Leu Ile Phe Val
     290                 295                 300

 ctc aga aag aga ata aaa ttg aca gtt gag ctt ttc caa atc aca aat     1020
 Leu Arg Lys Arg Ile Lys Leu Thr Val Glu Leu Phe Gln Ile Thr Asn
 305                 310                 315                 320

 aaa gcc atc agc agt gct ccc ttc ctg ctg ttc cag cca ctg tgg aca     1068
 Lys Ala Ile Ser Ser Ala Pro Phe Leu Leu Phe Gln Pro Leu Trp Thr
                 325                 330                 335

 ttt gcc atc ctc att ttc ttc tgg gtc ctc tgg gtg gct gtg ctg ctg     1116
 Phe Ala Ile Leu Ile Phe Phe Trp Val Leu Trp Val Ala Val Leu Leu
             340                 345                 350

 agc ctg gga act gca gga gct gcc cag gtt atg gaa ggc ggc caa gtg     1164
 Ser Leu Gly Thr Ala Gly Ala Ala Gln Val Met Glu Gly Gly Gln Val
         355                 360                 365

 gaa tat aag ccc ctt tcg ggc att cgg tac atg tgg tcg tac cat tta     1212
 Glu Tyr Lys Pro Leu Ser Gly Ile Arg Tyr Met Trp Ser Tyr His Leu
     370                 375                 380

 att ggc ctc atc tgg act agt gaa ttc atc ctt gcg tgc cag caa atg     1260
 Ile Gly Leu Ile Trp Thr Ser Glu Phe Ile Leu Ala Cys Gln Gln Met
 385                 390                 395                 400

 act ata gct ggg gca gtg gtt act tgt tat ttc aac aga agt aaa aat     1308
 Thr Ile Ala Gly Ala Val Val Thr Cys Tyr Phe Asn Arg Ser Lys Asn
                 405                 410                 415

 gat cct cct gat cat ccc atc ctt tcg tct ctc tcc att ctc ttc ttc     1356
 Asp Pro Pro Asp His Pro Ile Leu Ser Ser Leu Ser Ile Leu Phe Phe
             420                 425                 430

 tac cat caa gga acc att gtg aaa ggg tca ttt tta atc tct gtg gtg     1404
 Tyr His Gln Gly Thr Ile Val Lys Gly Ser Phe Leu Ile Ser Val Val
         435                 440                 445

 agg att ccg aga atc att gtc atg tac atg caa aac gca ctg aaa gaa     1452
 Arg Ile Pro Arg Ile Ile Val Met Tyr Met Gln Asn Ala Leu Lys Glu
     450                 455                 460

 cag cat ggt gca ttg tcc agg tac ctg ttc cga tgc tgc tac tgc tgt     1500
 Gln His Gly Ala Leu Ser Arg Tyr Leu Phe Arg Cys Cys Tyr Cys Cys
 465                 470                 475                 480

 ttc tgg tgt ctt gac aaa tac ctg ctc cat ctc aac cag aat gca tat     1548
 Phe Trp Cys Leu Asp Lys Tyr Leu Leu His Leu Asn Gln Asn Ala Tyr
                 485                 490                 495

 act aca act gct att aat ggg aca gat ttc tgt aca tca gca aaa gat     1596
 Thr Thr Thr Ala Ile Asn Gly Thr Asp Phe Cys Thr Ser Ala Lys Asp
             500                 505                 510

 gca ttc aaa atc ttg tcc aag aac tca agt cac ttt aca tct att aac     1644
 Ala Phe Lys Ile Leu Ser Lys Asn Ser Ser His Phe Thr Ser Ile Asn
         515                 520                 525

 tgc ttt gga gac ttc ata att ttt cta gga aag gtg tta gtg gtg tgt     1692
 Cys Phe Gly Asp Phe Ile Ile Phe Leu Gly Lys Val Leu Val Val Cys
     530                 535                 540

 ttc act gtt ttt gga gga ctc atg gct ttt aac tac aat cgg gca ttc     1740
 Phe Thr Val Phe Gly Gly Leu Met Ala Phe Asn Tyr Asn Arg Ala Phe
 545                 550                 555                 560

 cag gtg tgg gca gtc cct ctg tta ttg gta gct ttt ttt gcc tac tta     1788
 Gln Val Trp Ala Val Pro Leu Leu Leu Val Ala Phe Phe Ala Tyr Leu
                 565                 570                 575

 gta gcc cat agt ttt tta tct gtg ttt gaa act gtg ctg gat gca ctt     1836
 Val Ala His Ser Phe Leu Ser Val Phe Glu Thr Val Leu Asp Ala Leu
             580                 585                 590

 ttc ctg tgt ttt gct gtt gat ctg gaa aca aat gat gga tcg tca gaa     1884
 Phe Leu Cys Phe Ala Val Asp Leu Glu Thr Asn Asp Gly Ser Ser Glu
         595                 600                 605

 aag ccc tac ttt atg gat caa gaa ttt ctg agt ttc gta aaa agg agc     1932
 Lys Pro Tyr Phe Met Asp Gln Glu Phe Leu Ser Phe Val Lys Arg Ser
     610                 615                 620

 aac aaa tta aac aat gca agg gca cag cag gac aag cac tca tta agg     1980
 Asn Lys Leu Asn Asn Ala Arg Ala Gln Gln Asp Lys His Ser Leu Arg
 625                 630                 635                 640

 aat gag gag gga aca gaa ctc cag gcc att gtg aga taga tacccattta     2030
 Asn Glu Glu Gly Thr Glu Leu Gln Ala Ile Val Arg 
                 645                 650

 ggtatctgta cctggaaaac atttccttct aagagccatt tacagaatag aagatgagac   2090

 cactagagaa aagttagtga attttttttt aaaagaccta ataaacccta ttcttcctca   2150

 aaaaaaaaaa aa                                                       2162




      <210> 201
      <211> 873
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2)..(790)

      <400> 201
 c    atg gca ttc ctt tgg ctt gtg tcc tgc ttt gcc ctt gtg ggc gcc      46
      Met Ala Phe Leu Trp Leu Val Ser Cys Phe Ala Leu Val Gly Ala
        1               5                  10                  15

 acc ttt ggc tgt ggg gtc cct gcc atc caa ccc gtg ctg acc ggt ctg       94
 Thr Phe Gly Cys Gly Val Pro Ala Ile Gln Pro Val Leu Thr Gly Leu
                  20                  25                  30

 tcc agg atc gtc aac gga gag gat gct atc cct ggc tcc tgg ccc tgg      142
 Ser Arg Ile Val Asn Gly Glu Asp Ala Ile Pro Gly Ser Trp Pro Trp
              35                  40                  45

 cag gtg tcc ctg cag gac aga act ggc ttc cat ttc tgc ggg ggc tcc      190
 Gln Val Ser Leu Gln Asp Arg Thr Gly Phe His Phe Cys Gly Gly Ser
          50                  55                  60

 ctc atc agc gaa aac tgg gtg gtc act gct gcc cac tgc ggg gtc aag      238
 Leu Ile Ser Glu Asn Trp Val Val Thr Ala Ala His Cys Gly Val Lys
      65                  70                  75

 aca acc gat gtg gtg gta gct gga gag ttt gat cag ggc tcc gat gaa      286
 Thr Thr Asp Val Val Val Ala Gly Glu Phe Asp Gln Gly Ser Asp Glu
  80                  85                  90                  95

 gag aat gtc cag gtc ctg aaa atc gct cag gtt ttt aag aac ccc aag      334
 Glu Asn Val Gln Val Leu Lys Ile Ala Gln Val Phe Lys Asn Pro Lys
                 100                 105                 110

 ttc aac tcc ttc acc gtg cgt aat gac atc acc ctg ctg aag ctg gcc      382
 Phe Asn Ser Phe Thr Val Arg Asn Asp Ile Thr Leu Leu Lys Leu Ala
             115                 120                 125

 act cct gcc cag ttc tct gag act gtg tct gcc gtg tgt ctg ccc act      430
 Thr Pro Ala Gln Phe Ser Glu Thr Val Ser Ala Val Cys Leu Pro Thr
         130                 135                 140

 gtt gac gat gac ttc cct gct ggg aca ctg tgt gcc acc act ggc tgg      478
 Val Asp Asp Asp Phe Pro Ala Gly Thr Leu Cys Ala Thr Thr Gly Trp
     145                 150                 155

 ggc aag acc aaa tac aat gcc ctc aag acc cct gac aag ctg cag cag      526
 Gly Lys Thr Lys Tyr Asn Ala Leu Lys Thr Pro Asp Lys Leu Gln Gln
 160                 165                 170                 175

 gct gcc ctg ccc atc gtg tcc gag gct aag tgc aag gag tcc tgg ggt      574
 Ala Ala Leu Pro Ile Val Ser Glu Ala Lys Cys Lys Glu Ser Trp Gly
                 180                 185                 190

 tcc aag atc acc gat gtg atg atc tgc gca ggg ccc agt ggc gtc tct      622
 Ser Lys Ile Thr Asp Val Met Ile Cys Ala Gly Pro Ser Gly Val Ser
             195                 200                 205

 tcc tgc atg ggt gac tct ggt ggc ccc ctc gtc tgc cag aag gac gga      670
 Ser Cys Met Gly Asp Ser Gly Gly Pro Leu Val Cys Gln Lys Asp Gly
         210                 215                 220

 gtc tgg acc ctg gca ggc att gtg tcc tgg ggc agt ggt ttc tgc tcc      718
 Val Trp Thr Leu Ala Gly Ile Val Ser Trp Gly Ser Gly Phe Cys Ser
     225                 230                 235

 act tcc acc cct gcc gtg tat gcc cga gtc act gcc ctc atg ccc tgg      766
 Thr Ser Thr Pro Ala Val Tyr Ala Arg Val Thr Ala Leu Met Pro Trp
 240                 245                 250                 255

 gtt cag gag atc ttg gaa gcc aac taagtacacg gtcctttcct cttccctctt     820
 Val Gln Glu Ile Leu Glu Ala Asn 
                 260

 cctccccctc cgtgcatcta caataaaaat catctaatta gaaaaaaaaa aaa           873




      <210> 202
      <211> 1072
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (182)..(973)

      <400> 202
 gcagtcatga gtcgcttcaa gtttatcgat attggtatca acttgactga ccctatgttc     60

 agaggaattt ataggggggt tcaaaagcat caagatgact tacaggatgt aatagggaga    120

 gctgtcgaga ttggtgttaa aaagtttatg attacaggtg gaaatctaca agacagtaaa    180

 g    atg cac tgc att tgg cac aaa caa atg gta tcc tca tat ttc ttt     226
      Met His Cys Ile Trp His Lys Gln Met Val Ser Ser Tyr Phe Phe
        1               5                  10                  15

 tac caa aaa aaa aat gaa tta agt aat ttt gaa gaa gtc ttt ctg aaa      274
 Tyr Gln Lys Lys Asn Glu Leu Ser Asn Phe Glu Glu Val Phe Leu Lys
                  20                  25                  30

 act gct tca ggt atg ttt ttc agt aca gtt gga tgt cat cct aca aga      322
 Thr Ala Ser Gly Met Phe Phe Ser Thr Val Gly Cys His Pro Thr Arg
              35                  40                  45

 tgt ggt gaa ttt gaa aag aat aac cct gat ctt tac tta aag gag ttg      370
 Cys Gly Glu Phe Glu Lys Asn Asn Pro Asp Leu Tyr Leu Lys Glu Leu
          50                  55                  60

 cta aat ctt gct gaa aac aat aaa ggg aaa gtt gtg gca gta gga gaa      418
 Leu Asn Leu Ala Glu Asn Asn Lys Gly Lys Val Val Ala Val Gly Glu
      65                  70                  75

 tgt gga ctt gat ttt gac cga ctg cac ttt tgt ccc aaa gat act caa      466
 Cys Gly Leu Asp Phe Asp Arg Leu His Phe Cys Pro Lys Asp Thr Gln
  80                  85                  90                  95

 ctc aaa tac tgt gaa aaa cag ttt gaa ctg tca gaa caa aca aaa tta      514
 Leu Lys Tyr Cys Glu Lys Gln Phe Glu Leu Ser Glu Gln Thr Lys Leu
                 100                 105                 110

 cca atg ttt ctt cat tgt cga aac tca cat gct gaa ttt ttg gac ata      562
 Pro Met Phe Leu His Cys Arg Asn Ser His Ala Glu Phe Leu Asp Ile
             115                 120                 125

 att aaa aga aat aga gat cgg tgt gta ggg gga gtg gtg cat tca ttt      610
 Ile Lys Arg Asn Arg Asp Arg Cys Val Gly Gly Val Val His Ser Phe
         130                 135                 140

 gat ggt acc aag gaa gca gca gct gct ttg att gac ttg gat ctt tat      658
 Asp Gly Thr Lys Glu Ala Ala Ala Ala Leu Ile Asp Leu Asp Leu Tyr
     145                 150                 155

 ata gga ttt aat ggt tgc tca ctg aaa act gaa gct aat ttg gaa gtt      706
 Ile Gly Phe Asn Gly Cys Ser Leu Lys Thr Glu Ala Asn Leu Glu Val
 160                 165                 170                 175

 ttg aag tca att cct agt gaa aaa tta atg att gag aca gat gca cct      754
 Leu Lys Ser Ile Pro Ser Glu Lys Leu Met Ile Glu Thr Asp Ala Pro
                 180                 185                 190

 tgg tgt gga gtc aaa agt aca cat gct gga tca aaa tat ata aga act      802
 Trp Cys Gly Val Lys Ser Thr His Ala Gly Ser Lys Tyr Ile Arg Thr
             195                 200                 205

 gca ttt cct acc aaa aag aag tgg gaa agt ggg cac tgc tta aaa gac      850
 Ala Phe Pro Thr Lys Lys Lys Trp Glu Ser Gly His Cys Leu Lys Asp
         210                 215                 220

 aga aat gaa ccc tgc cat ata att caa ata ttg gag ata atg tca gca      898
 Arg Asn Glu Pro Cys His Ile Ile Gln Ile Leu Glu Ile Met Ser Ala
     225                 230                 235

 gtg aga gat gag gat cca ctg gaa tta gcc aat aca cta tat aac aat      946
 Val Arg Asp Glu Asp Pro Leu Glu Leu Ala Asn Thr Leu Tyr Asn Asn
 240                 245                 250                 255

 act att aaa gta ttt ttt cct gga ata taatt ggtatatgtc ttccactttc      998
 Thr Ile Lys Val Phe Phe Pro Gly Ile 
                 260

 catcatgtat gtaaaatttc atagtaaaac ttcctgatag tttcaataaa gaaattatct   1058

 gcaaaaaaaa aaaa                                                     1072




      <210> 203
      <211> 642
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (59)..(466)

      <400> 203
 cgactacaga atgaactgtt ggctttgcaa aatgacccac ctcctggaat gaccttaa       58                                                                 
 atg aga aga gtg ttc aaa att caa tta cac acg tgg att gta gac atg      106
 Met Arg Arg Val Phe Lys Ile Gln Leu His Thr Trp Ile Val Asp Met
   1               5                  10                  15

 gaa ggt gca cca ggt acc tta tat gaa ggg gaa aaa ttt caa ctt cta      154
 Glu Gly Ala Pro Gly Thr Leu Tyr Glu Gly Glu Lys Phe Gln Leu Leu
              20                  25                  30

 ttt aaa ttt agt agt cga tat cct ttt gac tct tct cag gtc atg ttt      202
 Phe Lys Phe Ser Ser Arg Tyr Pro Phe Asp Ser Ser Gln Val Met Phe
          35                  40                  45

 act ggt gaa aat att cct gtt cat cct cat gtt tat agc aat ggt cat      250
 Thr Gly Glu Asn Ile Pro Val His Pro His Val Tyr Ser Asn Gly His
      50                  55                  60

 atc tgt tta tcc att cta aca gaa gac tgg tcc cca gcg ctc tca gtc      298
 Ile Cys Leu Ser Ile Leu Thr Glu Asp Trp Ser Pro Ala Leu Ser Val
  65                  70                  75                  80

 caa tca gtt tgt ctt agc att att agc atg ctt tcc agc tgc aag gaa      346
 Gln Ser Val Cys Leu Ser Ile Ile Ser Met Leu Ser Ser Cys Lys Glu
                  85                  90                  95

 aag aga cga cca ccg gat aat tct ttt tat gtg cga aca tgt aac aag      394
 Lys Arg Arg Pro Pro Asp Asn Ser Phe Tyr Val Arg Thr Cys Asn Lys
             100                 105                 110

 aat cca aag aaa aca aaa tgg tgg tat cat ggg aaa ttt gaa cac aga      442
 Asn Pro Lys Lys Thr Lys Trp Trp Tyr His Gly Lys Phe Glu His Arg
         115                 120                 125

 gac ata cac aaa ggg aag aag atg tgaagataca ggaagaatgt gaagatggtc     496
 Asp Ile His Lys Gly Lys Lys Met 
     130                 135

 atctataaac caaagagagg cttgggacag accctaccct ctcagtcttc acaggacaac    556

 aaccctgccc gcaccttgat cttggacttc tagcttccag agctgtgaga aaataaatgt    616

 ctattgttta agccaaaaaa aaaaaa                                         642




      <210> 204
      <211> 815
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (11)..(790)

      <400> 204
 tgccatcgct   atg tct ctg caa aag acc cct ccg acc cga gtg ttc gtg      49
              Met Ser Leu Gln Lys Thr Pro Pro Thr Arg Val Phe Val
                1               5                  10

 gaa ctg gtt ccc tgg gct gac cgg agc cgg gag aac aac ctg gcc tca       97
 Glu Leu Val Pro Trp Ala Asp Arg Ser Arg Glu Asn Asn Leu Ala Ser
      15                  20                  25

 ggg aga gag acg cta ccg ggc tta cgc cac ccc ctc tcc tca aca caa      145
 Gly Arg Glu Thr Leu Pro Gly Leu Arg His Pro Leu Ser Ser Thr Gln
  30                  35                  40                  45

 gcc caa act gct acc cgc gag gtg caa gta agc ggc acc tca gaa gtg      193
 Ala Gln Thr Ala Thr Arg Glu Val Gln Val Ser Gly Thr Ser Glu Val
                  50                  55                  60

 tct gcg ggc cct gac cgg gcg cag gtg gtg gtg cga gtg agc agc acc      241
 Ser Ala Gly Pro Asp Arg Ala Gln Val Val Val Arg Val Ser Ser Thr
              65                  70                  75

 aag gag gcg gca gcc gag gcc aaa aag agc gtt tgt cgc cgt cta gat      289
 Lys Glu Ala Ala Ala Glu Ala Lys Lys Ser Val Cys Arg Arg Leu Asp
          80                  85                  90

 tac atc acg cag agc ctc cag cag cag ggc gtg cag gca gaa aat ata      337
 Tyr Ile Thr Gln Ser Leu Gln Gln Gln Gly Val Gln Ala Glu Asn Ile
      95                 100                 105

 act gtg aca aag gat ttt agg aga gtg gaa aat gct tat cac atg gaa      385
 Thr Val Thr Lys Asp Phe Arg Arg Val Glu Asn Ala Tyr His Met Glu
 110                 115                 120                 125

 gca gag gtc tgc att aca ttt act gaa ttt gga aaa atg caa aat att      433
 Ala Glu Val Cys Ile Thr Phe Thr Glu Phe Gly Lys Met Gln Asn Ile
                 130                 135                 140

 tgt aac ttt ctt gtt gaa aag cta gat agc tct gtt gtc atc agc cca      481
 Cys Asn Phe Leu Val Glu Lys Leu Asp Ser Ser Val Val Ile Ser Pro
             145                 150                 155

 ccc cag ttc tat cat act cca ggt tct gtt gag aat ctt cga cgg caa      529
 Pro Gln Phe Tyr His Thr Pro Gly Ser Val Glu Asn Leu Arg Arg Gln
         160                 165                 170

 gcc tgt ctt gtt gct gtt gag aat gcg tgg cgc aaa gct caa gaa gtc      577
 Ala Cys Leu Val Ala Val Glu Asn Ala Trp Arg Lys Ala Gln Glu Val
     175                 180                 185

 tgt aac ctt gtt ggc caa acc tta gga aaa cct tta cta atc aaa gaa      625
 Cys Asn Leu Val Gly Gln Thr Leu Gly Lys Pro Leu Leu Ile Lys Glu
 190                 195                 200                 205

 gaa gaa aca aaa gaa tgg gaa ggc caa ata gat gat cac cag tca tcc      673
 Glu Glu Thr Lys Glu Trp Glu Gly Gln Ile Asp Asp His Gln Ser Ser
                 210                 215                 220

 aga ctc tca agt tca tta act gta caa caa aaa atc aaa agt gca aca      721
 Arg Leu Ser Ser Ser Leu Thr Val Gln Gln Lys Ile Lys Ser Ala Thr
             225                 230                 235

 ata cat gct gct tca aaa gta ttt ata act ttt gag gta aag gga aaa      769
 Ile His Ala Ala Ser Lys Val Phe Ile Thr Phe Glu Val Lys Gly Lys
         240                 245                 250

 gag aag aga aaa aag cac ctt tgaaattcca aacaaaaaaa aaaaa              815
 Glu Lys Arg Lys Lys His Leu 
     255                 260





      <210> 205
      <211> 883
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (121)..(660)

      <400> 205
 cgacccacgc gtccgggctg gccggtcgca gggtaggggg tccgtggacc tcccggcctg     60

 tagggggcgt cgggcgcagc ggaagggcct gctccggagc ctggccaggg ctgcgcagtc    120
                                                                 
 atg atc acc gag acc gcg gcg gag cct acg gtc cct gca gtg cct gct      168
 Met Ile Thr Glu Thr Ala Ala Glu Pro Thr Val Pro Ala Val Pro Ala
   1               5                  10                  15

 gct gag gag gcc acc gaa gct cgg gga cgc gag gag ccg gcg tgg ccc      216
 Ala Glu Glu Ala Thr Glu Ala Arg Gly Arg Glu Glu Pro Ala Trp Pro
              20                  25                  30

 tgg aaa gac gcc ccg atc cgg acg ctg gtg cag cgc atc cac cag ctg      264
 Trp Lys Asp Ala Pro Ile Arg Thr Leu Val Gln Arg Ile His Gln Leu
          35                  40                  45

 cag gct gag cgc gcg cag ggc ttc cgc cga ctg gag gag tgg ttg gcg      312
 Gln Ala Glu Arg Ala Gln Gly Phe Arg Arg Leu Glu Glu Trp Leu Ala
      50                  55                  60

 ccg gtg cag ggc ctg aga gcc tgg ggg cgc ggc ctc agg gtc ccc aca      360
 Pro Val Gln Gly Leu Arg Ala Trp Gly Arg Gly Leu Arg Val Pro Thr
  65                  70                  75                  80

 tgc cgc aga ggc cac cgc cag tac ctg cgc agc ggc cct gac tac gac      408
 Cys Arg Arg Gly His Arg Gln Tyr Leu Arg Ser Gly Pro Asp Tyr Asp
                  85                  90                  95

 ttc gcg cgc tac cgg agc aca gtg cac ggg gtt gac cca ggc ctt cgc      456
 Phe Ala Arg Tyr Arg Ser Thr Val His Gly Val Asp Pro Gly Leu Arg
             100                 105                 110

 cgc cgc ctc gcg gga ggt gct ggc ggt gga agc aga gct ggg cgg gcc      504
 Arg Arg Leu Ala Gly Gly Ala Gly Gly Gly Ser Arg Ala Gly Arg Ala
         115                 120                 125

 tcg cag gca gcc gct gct cgc cgg cca cgt gcg cag cct gca gga gct      552
 Ser Gln Ala Ala Ala Ala Arg Arg Pro Arg Ala Gln Pro Ala Gly Ala
     130                 135                 140

 gga gca gac gcg gct ggg cac ggt ggc cct gct gca gtt gat gga gac      600
 Gly Ala Asp Ala Ala Gly His Gly Gly Pro Ala Ala Val Asp Gly Asp
 145                 150                 155                 160

 gcc aga gct ggc ggg gca gga gga cgc tgt acg gat gca gca gct gaa      648
 Ala Arg Ala Gly Gly Ala Gly Gly Arg Cys Thr Asp Ala Ala Ala Glu
                 165                 170                 175

 aat gaa ggt aat taa aaccatggag gcgatcagcg aggttctcca ggaccttagg      703
 Asn Glu Gly Asn 
             180

 tttgatgcgg aatctgccga gtgatggcgg ctccccaggg atgcgccgag ggagatggga    763

 aacggggcgg atggcgccca gcccagccct aactgccagc tggctggggt cgcgccccac    823

 tgcgctgctg accttcctgc agttccagac acctcccaca ataaagagct cctcctctgt    883




      <210> 206
      <211> 817
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (121)..(594)

      <400> 206
 cgacccacgc gtccgggctg gccggtcgca gggtaggggg tccgtggacc tcccggcctg     60

 tagggggcgt cgggcgcagc ggaagggcct gctccggagc ctggccaggg ctgcgcagtc    120
                                                                 
 atg atc acc gag acc gcg gcg gag cct acg gtc cct gca gtg cct gct      168
 Met Ile Thr Glu Thr Ala Ala Glu Pro Thr Val Pro Ala Val Pro Ala
   1               5                  10                  15

 gct gag gag gcc acc gaa gct cgg gga cgc gag gag ccg gcg tgg ccc      216
 Ala Glu Glu Ala Thr Glu Ala Arg Gly Arg Glu Glu Pro Ala Trp Pro
              20                  25                  30

 tgg aaa gac gcc ccg atc cgg acg ctg gtg cag cgc atc cac cag ctg      264
 Trp Lys Asp Ala Pro Ile Arg Thr Leu Val Gln Arg Ile His Gln Leu
          35                  40                  45

 cag gct gag cgc gcg cag ggc ttc cgc cga ctg gag gaa ggc cac cgc      312
 Gln Ala Glu Arg Ala Gln Gly Phe Arg Arg Leu Glu Glu Gly His Arg
      50                  55                  60

 cag tac ctg cgc agc ggc cct gac tac gac ttc gcg cgc tac cgg agc      360
 Gln Tyr Leu Arg Ser Gly Pro Asp Tyr Asp Phe Ala Arg Tyr Arg Ser
  65                  70                  75                  80

 aca gtg cac ggg gtt gac cca ggc ctt cgc cgc cgc ctc gcg gga ggt      408
 Thr Val His Gly Val Asp Pro Gly Leu Arg Arg Arg Leu Ala Gly Gly
                  85                  90                  95

 gct ggc ggt gga agc aga gct ggg cgg gcc tcg cag gca gcc gct gct      456
 Ala Gly Gly Gly Ser Arg Ala Gly Arg Ala Ser Gln Ala Ala Ala Ala
             100                 105                 110

 cgc cgg cca cgt gcg cag cct gca gga gct gga gca gac gcg gct ggg      504
 Arg Arg Pro Arg Ala Gln Pro Ala Gly Ala Gly Ala Asp Ala Ala Gly
         115                 120                 125

 cac ggt ggc cct gct gca gtt gat gga gac gcc aga gct ggc ggg gca      552
 His Gly Gly Pro Ala Ala Val Asp Gly Asp Ala Arg Ala Gly Gly Ala
     130                 135                 140

 gga gga cgc tgt acg gat gca gca gct gaa aat gaa ggt aat taaaacc      601
 Gly Gly Arg Cys Thr Asp Ala Ala Ala Glu Asn Glu Gly Asn 
 145                 150                 155

 atggaggcga tcagcgaggt tctccaggac cttaggtttg atgcggaatc tgccgagtga    661

 tggcggctcc ccagggatgc gccgagggag atgggaaacg gggcggatgg cgcccagccc    721

 agccctaact gccagctggc tggggtcgcg ccccactgcg ctgctgacct tcctgcagtt    781

 ccagacacct cccacaataa agagctcctc ctctgt                              817




      <210> 207
      <211> 2818
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (41)..(1666)

      <220>
      <221> misc_feature
      <222> (1)...(2818)
      <223> n = a,t,c or g

      <400> 207
 gtgggcggac gcgtggggga aatttagaaa cagaggactt  atg cag aag cat ttg      55
                                              Met Gln Lys His Leu
                                                1               5

 aag aat cat gtt aag aag ata cag agg cag caa att gct gca gct caa      103
 Lys Asn His Val Lys Lys Ile Gln Arg Gln Gln Ile Ala Ala Ala Gln
                  10                  15                  20

 cag gat gat cag gaa gtc act gct ttg gaa gaa ata aat tgt tct agt      151
 Gln Asp Asp Gln Glu Val Thr Ala Leu Glu Glu Ile Asn Cys Ser Ser
              25                  30                  35

 tct tcc att tca ttt gaa aat ggg aat tct gat agt aag gat ttg gaa      199
 Ser Ser Ile Ser Phe Glu Asn Gly Asn Ser Asp Ser Lys Asp Leu Glu
          40                  45                  50

 gtg gag aca ctt act gct tct agt gaa gga aac aaa gaa gtc atc cct      247
 Val Glu Thr Leu Thr Ala Ser Ser Glu Gly Asn Lys Glu Val Ile Pro
      55                  60                  65

 gag cat gtg gct gaa ttc att gaa att ccc ata agt gta cca gaa gat      295
 Glu His Val Ala Glu Phe Ile Glu Ile Pro Ile Ser Val Pro Glu Asp
  70                  75                  80                  85

 gtt att gaa aat gtt att gaa aat ggc agt cct aat aat tct tta aat      343
 Val Ile Glu Asn Val Ile Glu Asn Gly Ser Pro Asn Asn Ser Leu Asn
                  90                  95                 100

 aat gtt ttc aag cct tta act gaa tgt ggg gat gat tat gag gag gaa      391
 Asn Val Phe Lys Pro Leu Thr Glu Cys Gly Asp Asp Tyr Glu Glu Glu
             105                 110                 115

 gag gat gaa gaa ggt gat tat gaa gaa gat gat tat gac ctg aat caa      439
 Glu Asp Glu Glu Gly Asp Tyr Glu Glu Asp Asp Tyr Asp Leu Asn Gln
         120                 125                 130

 gaa act tca gta att cat aaa atc aat gga act gtg tgc cat cca aaa      487
 Glu Thr Ser Val Ile His Lys Ile Asn Gly Thr Val Cys His Pro Lys
     135                 140                 145

 gac ata tat gcc aca gat caa gaa gga aac ttt aag tgt cct gct ctt      535
 Asp Ile Tyr Ala Thr Asp Gln Glu Gly Asn Phe Lys Cys Pro Ala Leu
 150                 155                 160                 165

 ggt tgt gtc cgg ata ttt aaa aga att ggg ttt cta aat aaa cat gca      583
 Gly Cys Val Arg Ile Phe Lys Arg Ile Gly Phe Leu Asn Lys His Ala
                 170                 175                 180

 atg acc gta cat cca acc gat tta aat gtg cga caa aca gta atg aag      631
 Met Thr Val His Pro Thr Asp Leu Asn Val Arg Gln Thr Val Met Lys
             185                 190                 195

 tgg agc aaa gga aaa tgc aaa ttt tgt caa agg caa ttt gaa gat tct      679
 Trp Ser Lys Gly Lys Cys Lys Phe Cys Gln Arg Gln Phe Glu Asp Ser
         200                 205                 210

 caa cat ttt ata gac caa ctt aat aga cat agc tat cca aat gtg tat      727
 Gln His Phe Ile Asp Gln Leu Asn Arg His Ser Tyr Pro Asn Val Tyr
     215                 220                 225

 ttt tgt ttg cat ttt aat tgc aac gag tcg ttt aag ctg ccg ttc cag      775
 Phe Cys Leu His Phe Asn Cys Asn Glu Ser Phe Lys Leu Pro Phe Gln
 230                 235                 240                 245

 ctt gcc cag cac aca aaa agt cac agg aca ttt cag gct cag tgt agt      823
 Leu Ala Gln His Thr Lys Ser His Arg Thr Phe Gln Ala Gln Cys Ser
                 250                 255                 260

 ttt cca gaa tgc cat gag ctt ttt gaa gat ctt cct ctg ctg tat gaa      871
 Phe Pro Glu Cys His Glu Leu Phe Glu Asp Leu Pro Leu Leu Tyr Glu
             265                 270                 275

 cat gaa gct caa cac tat tta agt aaa aca cca gag tca tct gca caa      919
 His Glu Ala Gln His Tyr Leu Ser Lys Thr Pro Glu Ser Ser Ala Gln
         280                 285                 290

 cca agt gaa aca att ctt tgg gat gtt cag aca gac tca aat cct aat      967
 Pro Ser Glu Thr Ile Leu Trp Asp Val Gln Thr Asp Ser Asn Pro Asn
     295                 300                 305

 cag gaa aaa gac tca tct agt aat gag aaa caa act att agt ctg cca     1015
 Gln Glu Lys Asp Ser Ser Ser Asn Glu Lys Gln Thr Ile Ser Leu Pro
 310                 315                 320                 325

 gtt tct act agc aaa tca agg aaa gag tct aca gaa cca aag aca tgt     1063
 Val Ser Thr Ser Lys Ser Arg Lys Glu Ser Thr Glu Pro Lys Thr Cys
                 330                 335                 340

 ata gaa agt atg gaa aag aaa aca gac agt tta gtt cag aat gga aac     1111
 Ile Glu Ser Met Glu Lys Lys Thr Asp Ser Leu Val Gln Asn Gly Asn
             345                 350                 355

 gaa cgt tct gat gac act gtt tca aat ata agc ttg ata gac caa aag     1159
 Glu Arg Ser Asp Asp Thr Val Ser Asn Ile Ser Leu Ile Asp Gln Lys
         360                 365                 370

 atg cct gac ata gag cca aat tct gaa aat aat tgt agt agt agt gat     1207
 Met Pro Asp Ile Glu Pro Asn Ser Glu Asn Asn Cys Ser Ser Ser Asp
     375                 380                 385

 ata gtc aat gga cac agt gaa ata gag caa aca cct tta gtt tca tca     1255
 Ile Val Asn Gly His Ser Glu Ile Glu Gln Thr Pro Leu Val Ser Ser
 390                 395                 400                 405

 gat cct gct ttg aaa att gat aca aac aga atc agg aca gaa aat ggt     1303
 Asp Pro Ala Leu Lys Ile Asp Thr Asn Arg Ile Arg Thr Glu Asn Gly
                 410                 415                 420

 tcc att ttg ccc agt gtt gta cca caa gaa cac aac acc ttg cca gta     1351
 Ser Ile Leu Pro Ser Val Val Pro Gln Glu His Asn Thr Leu Pro Val
             425                 430                 435

 tct cag gca cct tcc aaa cca aat ctg aca agt gaa cat act tca tat     1399
 Ser Gln Ala Pro Ser Lys Pro Asn Leu Thr Ser Glu His Thr Ser Tyr
         440                 445                 450

 ggc tta att tta aca aaa cca tac gtc aga cca ttg cct ccc agt tac     1447
 Gly Leu Ile Leu Thr Lys Pro Tyr Val Arg Pro Leu Pro Pro Ser Tyr
     455                 460                 465

 ctt gat gaa cgg tat ctt agt atg cca aaa cgc aga aaa ttt ctg act     1495
 Leu Asp Glu Arg Tyr Leu Ser Met Pro Lys Arg Arg Lys Phe Leu Thr
 470                 475                 480                 485

 gat aga gta gat gcc tgt tct gat caa gat aac gtg tat aaa aaa tca     1543
 Asp Arg Val Asp Ala Cys Ser Asp Gln Asp Asn Val Tyr Lys Lys Ser
                 490                 495                 500

 gtg aaa aga tta aga tgt ggc aaa tgc ctg acc acc tac tgt aat gca     1591
 Val Lys Arg Leu Arg Cys Gly Lys Cys Leu Thr Thr Tyr Cys Asn Ala
             505                 510                 515

 gaa gca ctt gag gct cat ctt gca caa aag aaa tgt cag aca ctc ttt     1639
 Glu Ala Leu Glu Ala His Leu Ala Gln Lys Lys Cys Gln Thr Leu Phe
         520                 525                 530

 gga ttt gat tca gat gat gaa agt gcc tgatg aaaatggttc agaaagatct     1691
 Gly Phe Asp Ser Asp Asp Glu Ser Ala 
     535                 540

 gtcaatcaag cagtagtgtg aaaaaagcac tataagaaaa tgcatcatca gtttgctatt   1751

 tccctgatgg ccttaatttt agagtggtct tggattacta aagataaaga caaagcacat   1811

 tttctagaat gaactcacag agatgtgctg gcttagactc caaaaggatt ataaaactcc   1871

 caaagtacca gttttccaga aaaccacatt ttacagttta tgatgattaa tagcagcagc   1931

 atgttcagtt tcgcttatat gagaaacatg tttaggcaac tagtcagaaa accagctatg   1991

 gccttacaga aagggaaaag tttaacccat tattaaaaag tgtgtgtggg aggggggctg   2051

 gtttacaata ttaaaccatt taaagtattt tattctacaa atggggtttg ttttcttgtc   2111

 atgcataatc agattatgtc ccctcccttc tggttaaaca tggtttaagg aaccgctgct   2171

 gtttggtttg tgattgattt agaaacttat acattaactt accacagtgc tatcaattaa   2231

 agattgtaac aggtttccag atgattaatt aggtcaaagt tcaatgaatg gcacgccagc   2291

 attgaaaatt aaaaaacaaa acaaaaaaaa aaccacagtg ctttgctaat aagctcttga   2351

 tagaacctcc cactaaccac ttttgtggta caaattagtt aacatttaaa gggcagcagt   2411

 gtcaataaaa tagaaaaaaa ccgatcagta ctctggggag agatgaaagg aatctaagac   2471

 tttacaggct ttgtagttga aggaaaacac tgaattgcaa attattcaat gtgaataatg   2531

 gtaaaagcac actgggatac ttctgtttgt gtatatgttg ggacattgct tgatgattca   2591

 tagtaaggtc ctttagacat taatgtgagt tatctaagta cagtcctatt aaaataactg   2651

 gctcaaaaaa tcagctaaga atcaggttga gaaatcattc attttattct attaggagag   2711

 gtaattccaa aagaagccat actattcctg tttttttaat tcattagtga tgacttggnc   2771

 tgaacagtaa tttttatatg taaaaggaag tatttacaca aaacatt                 2818




      <210> 208
      <211> 1243
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (159)..(839)

      <400> 208
 tctgggagag aggagtgtca gacagctgtt gtcaacaggc acctggccag agtgaaaagg     60

 aggggcagat tccatccaag tcccagcggc gccagctgac actctctgcc aatgcccagg    120

 tgctgagcga cagtgtccca ccggtccctg tgcccaga    atg gcc tgc acc aag     173
                                              Met Ala Cys Thr Lys
                                                1               5

 acc ctg caa cag tcc cag ccc atc tcc gca gga gcc acc aca acc acc      221
 Thr Leu Gln Gln Ser Gln Pro Ile Ser Ala Gly Ala Thr Thr Thr Thr
                  10                  15                  20

 acc gct gtg gcc cct gct ggg ggt cat tct ggc tcc aca gaa tgt gac      269
 Thr Ala Val Ala Pro Ala Gly Gly His Ser Gly Ser Thr Glu Cys Asp
              25                  30                  35

 ctg gag tgt ctg gtg tgc cgg gag ccc tac agc tgt ccc cgg ttg ccc      317
 Leu Glu Cys Leu Val Cys Arg Glu Pro Tyr Ser Cys Pro Arg Leu Pro
          40                  45                  50

 aag ctg ctg gcc tgc cag cat gcc ttc tgc gcc atc tgc ctg aag ctc      365
 Lys Leu Leu Ala Cys Gln His Ala Phe Cys Ala Ile Cys Leu Lys Leu
      55                  60                  65

 ctg ctg tgc gtg cag gac aac acc tgg tcc atc acc tgc ccg ctg tgc      413
 Leu Leu Cys Val Gln Asp Asn Thr Trp Ser Ile Thr Cys Pro Leu Cys
  70                  75                  80                  85

 cgc aag gtc acc gcc gtc ccc ggg ggc ctc atc tgc agc ctg cgc gac      461
 Arg Lys Val Thr Ala Val Pro Gly Gly Leu Ile Cys Ser Leu Arg Asp
                  90                  95                 100

 cat gag gcg gtg gtg ggg cag ctg gcc cag cca tgc aca gag gta tcg      509
 His Glu Ala Val Val Gly Gln Leu Ala Gln Pro Cys Thr Glu Val Ser
             105                 110                 115

 ctc tgt cct cag ggg ctg gtg gat cct gct gac ttg gca gca gga cac      557
 Leu Cys Pro Gln Gly Leu Val Asp Pro Ala Asp Leu Ala Ala Gly His
         120                 125                 130

 ccc agc ttg gtg gga gag gat gga cag gat gaa gta agt gca aac cac      605
 Pro Ser Leu Val Gly Glu Asp Gly Gln Asp Glu Val Ser Ala Asn His
     135                 140                 145

 gtg gca gcc cgg cgc ctg gcc gcg cac cta ctc ctg ctg gcc ttg ctc      653
 Val Ala Ala Arg Arg Leu Ala Ala His Leu Leu Leu Leu Ala Leu Leu
 150                 155                 160                 165

 att atc ctc atc ggg ccc ttc atc tac ccg ggt gtc tta cga tgg gtg      701
 Ile Ile Leu Ile Gly Pro Phe Ile Tyr Pro Gly Val Leu Arg Trp Val
                 170                 175                 180

 ctc acc ttc atc atc gcc ctg gcc ctg ctg atg tcc acc ctc ttc tgc      749
 Leu Thr Phe Ile Ile Ala Leu Ala Leu Leu Met Ser Thr Leu Phe Cys
             185                 190                 195

 tgt ctc ccc agc acc cgg ggc agc tgc tgg ccc tcc tcc agg act ctc      797
 Cys Leu Pro Ser Thr Arg Gly Ser Cys Trp Pro Ser Ser Arg Thr Leu
         200                 205                 210

 ttc tgc aga gag cag aaa cac agc cac atc tct tcc att gcc tgagtgc      846
 Phe Cys Arg Glu Gln Lys His Ser His Ile Ser Ser Ile Ala 
     215                 220                 225

 cctctgatga ggctatccct gcagcccttt ctgcccttgg gcccccggac ttccacaatg    906

 aacagggtaa ggggttacgg actaagactg gctcctttgg gaaatcacat gccagcggga    966

 cttgcaagcc acaaccgaga tggccagcct gggtcaagaa ttacacgctt ggatgacagg   1026

 cttgcacttg cccttgggat agcatagcta aaactgttgg tggctagggg agcagacaca   1086

 aactacttga acatgacaag atgggggaag ctcctgttcc tcttattcca atgttcttgg   1146

 tttttcttta tataacttga tgaaagtatt gcagtattga tgccattgta gaatagaact   1206

 ggaattccat tctttttgca atttaaaaaa aaaaaaa                            1243




      <210> 209
      <211> 2145
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (200)..(1543)

      <400> 209
 taagcttgcg gccgcagctt ctccacattt tcgttaacgc cattctcaag caagcgcatc     60

 aatatattta gttccggcct ctttgcacgt catttccggc accggcatgg ccgggtgagc    120

 tgcaggctac cttatttaag accgggaatt tagtcagcct ggtgagccga ctctgaggag    180

 atggagtatc gctgaggtg atg aga gag aat gtg gtt gtt agc aac atg gag     232
                      Met Arg Glu Asn Val Val Val Ser Asn Met Glu
                        1               5                  10

 aga gaa agt ggg aag ccc gtg gct gtt gtc gca gtt gtg act gag cct      280
 Arg Glu Ser Gly Lys Pro Val Ala Val Val Ala Val Val Thr Glu Pro
              15                  20                  25

 tgg ttt acc cag cga tac aga gaa tat ctc cag agg cag aaa ctc ttt      328
 Trp Phe Thr Gln Arg Tyr Arg Glu Tyr Leu Gln Arg Gln Lys Leu Phe
          30                  35                  40

 gat aca cag cac cgt gtg gaa aag atg ccg gat ggc tcg gtg gcg cta      376
 Asp Thr Gln His Arg Val Glu Lys Met Pro Asp Gly Ser Val Ala Leu
      45                  50                  55

 ccg gtg ctg gga gag acg ctt cca gag cag cac ctg cag gag ctg agg      424
 Pro Val Leu Gly Glu Thr Leu Pro Glu Gln His Leu Gln Glu Leu Arg
  60                  65                  70                  75

 aat cgt gtt gcc cca ggc agt ccc tgt atg ctc acg cag ctc ccg gat      472
 Asn Arg Val Ala Pro Gly Ser Pro Cys Met Leu Thr Gln Leu Pro Asp
                  80                  85                  90

 cct gtt cct tcg aag agg gcc cag ggt tgt tca cct gcc caa aaa ttg      520
 Pro Val Pro Ser Lys Arg Ala Gln Gly Cys Ser Pro Ala Gln Lys Leu
              95                 100                 105

 tgt ctt gag gtg agt cgc tgg gtg gag ggt cgg gga gtc aag tgg tca      568
 Cys Leu Glu Val Ser Arg Trp Val Glu Gly Arg Gly Val Lys Trp Ser
         110                 115                 120

 gcc gag ttg gag gct gat ttg ccc cga tca tgg caa cgg cat ggt aat      616
 Ala Glu Leu Glu Ala Asp Leu Pro Arg Ser Trp Gln Arg His Gly Asn
     125                 130                 135

 ctc ttg ttg ctg agt gaa gac tgt ttc caa gcc aag cag tgg aaa aat      664
 Leu Leu Leu Leu Ser Glu Asp Cys Phe Gln Ala Lys Gln Trp Lys Asn
 140                 145                 150                 155

 ctg gga ccg gaa ctc tgg gag acc gtt gcc ttg gca ctt ggc gtc cag      712
 Leu Gly Pro Glu Leu Trp Glu Thr Val Ala Leu Ala Leu Gly Val Gln
                 160                 165                 170

 cgt ttg gca aaa cga ggg cgg gta tca ccg gat ggt act cga act cca      760
 Arg Leu Ala Lys Arg Gly Arg Val Ser Pro Asp Gly Thr Arg Thr Pro
             175                 180                 185

 gca gtg aca ctg ctg ctg ggt gac cat ggc tgg gta gag cat gtg gat      808
 Ala Val Thr Leu Leu Leu Gly Asp His Gly Trp Val Glu His Val Asp
         190                 195                 200

 aat ggt atc cgt tat aag ttt gac gtg acc cag tgt atg ttc tcc ttt      856
 Asn Gly Ile Arg Tyr Lys Phe Asp Val Thr Gln Cys Met Phe Ser Phe
     205                 210                 215

 gga aac atc act gag aag ctt cga gtg gca tcg ttg tcc tgt gct gga      904
 Gly Asn Ile Thr Glu Lys Leu Arg Val Ala Ser Leu Ser Cys Ala Gly
 220                 225                 230                 235

 gaa gtg ctg gtg gat ctc tat gca ggg att ggt tat ttt aca ttg cct      952
 Glu Val Leu Val Asp Leu Tyr Ala Gly Ile Gly Tyr Phe Thr Leu Pro
                 240                 245                 250

 ttc cta gtt cat gct ggt gct gcc ttc gtc cat gct tgt gag tgg aat     1000
 Phe Leu Val His Ala Gly Ala Ala Phe Val His Ala Cys Glu Trp Asn
             255                 260                 265

 ccc cat gct gta gtt gct ctg aga aat aac ctt gag atc aat gga gta     1048
 Pro His Ala Val Val Ala Leu Arg Asn Asn Leu Glu Ile Asn Gly Val
         270                 275                 280

 gca gat cgg tgc caa ata cac ttt gga gat aac aga aaa ctg aag ctc     1096
 Ala Asp Arg Cys Gln Ile His Phe Gly Asp Asn Arg Lys Leu Lys Leu
     285                 290                 295

 tca aat att gca gat agg gtg atc ctg ggg ctg att ccc agc tct gaa     1144
 Ser Asn Ile Ala Asp Arg Val Ile Leu Gly Leu Ile Pro Ser Ser Glu
 300                 305                 310                 315

 gaa ggc tgg ccc att gcc tgc caa gtg tta agg cag gat gct gga ggc     1192
 Glu Gly Trp Pro Ile Ala Cys Gln Val Leu Arg Gln Asp Ala Gly Gly
                 320                 325                 330

 att ttg cat atc cac caa aat gtg gaa tct ttc cca ggg aag aat ctt     1240
 Ile Leu His Ile His Gln Asn Val Glu Ser Phe Pro Gly Lys Asn Leu
             335                 340                 345

 cag gct ctt gga gtc agc aaa gta gag aaa gag cat tgg ctg tat cct     1288
 Gln Ala Leu Gly Val Ser Lys Val Glu Lys Glu His Trp Leu Tyr Pro
         350                 355                 360

 cag caa att acc acc aac caa tgg aaa aat gga gct acc agg gat tct     1336
 Gln Gln Ile Thr Thr Asn Gln Trp Lys Asn Gly Ala Thr Arg Asp Ser
     365                 370                 375

 agg gga aaa atg ctg tca cca gcc acc aag cca gag tgg caa agg tgg     1384
 Arg Gly Lys Met Leu Ser Pro Ala Thr Lys Pro Glu Trp Gln Arg Trp
 380                 385                 390                 395

 gca gaa tct gca gaa act cga atc gcc act ctt ctt cag cag gtg cat     1432
 Ala Glu Ser Ala Glu Thr Arg Ile Ala Thr Leu Leu Gln Gln Val His
                 400                 405                 410

 ggg aaa cca tgg aag aca caa att ctg cac atc caa cca gtg aaa tcc     1480
 Gly Lys Pro Trp Lys Thr Gln Ile Leu His Ile Gln Pro Val Lys Ser
             415                 420                 425

 tat gct ccc cat gtg gat cac ata gtc ctg gat ctg gaa tgc tgc ccc     1528
 Tyr Ala Pro His Val Asp His Ile Val Leu Asp Leu Glu Cys Cys Pro
         430                 435                 440

 tgt cct tca gtt ggc tagaggaggt agatcctggg acacatggga tccacgtgcg     1583
 Cys Pro Ser Val Gly 
     445

 agtggccctt aaatgtatca gttcagtcca ggttgtcatc ccttttgtcc cctggtgatc   1643

 agtttttttc atattttata gccctgaaag caggctctag atcaattcaa attatttcat   1703

 ttgtctttca ttgataacag aaaatgaaat acctgtttgg gagaagcagc atggcccatt   1763

 gaaatgaggc tcatctgtgc aattatgaat tccaaattct gacctcagtt ctggaattga   1823

 agtttcagta tgttttggcc tcgggtttcg ttatttgcaa aatgagagtt tctttgaact   1883

 gtctcacgtg actattaagc aactatacac aggacatcgg ttattttaga gtgaaagaca   1943

 cagtgctttt tccaaattgc tctggctacc atatagaaaa ttgactgaag gagggccaag   2003

 atggaaacag agagaccagt gaggaggctt ctgtggttgt ccaggtctga ggtgatggta   2063

 acttggactc ggatggtggt aatgggaggt agattgatat gataaataaa attgacagac   2123

 caagcaatgg aaaaaaaaaa aa                                            2145




      <210> 210
      <211> 2293
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (176)..(2191)

      <400> 210
 catctccccc aacctggggg tcgtgttctt caacgcctgc gaggccgcgt cgcggctggc     60

 gcgcggcgag gatgaggcgg agctggcgct gagcctcctg gcgcagctgg gcatcacgcc    120

 tctgccactc agccgcggcc ccgtgccagc caaacccacc gtgctcttcg agaag atg     178
                                                              Met
                                                                1

 ggc gtg ggc cgg ctg gac atg tat gtg ctg cac ccg ccc tcc gcc ggc      226
 Gly Val Gly Arg Leu Asp Met Tyr Val Leu His Pro Pro Ser Ala Gly
               5                  10                  15

 gcc gag cgc acg ctg gcc tct gtg tgc gcc ctg ctg gtg tgg cac ccc      274
 Ala Glu Arg Thr Leu Ala Ser Val Cys Ala Leu Leu Val Trp His Pro
          20                  25                  30

 gcc ggc ccc ggc gag aag gtg gtg cgc gtg ctg ttc ccc ggt tgc acc      322
 Ala Gly Pro Gly Glu Lys Val Val Arg Val Leu Phe Pro Gly Cys Thr
      35                  40                  45

 ccg ccc gcc tgc ctc ctg gac ggc ctg gtc cgc ctg cag cac ttg agg      370
 Pro Pro Ala Cys Leu Leu Asp Gly Leu Val Arg Leu Gln His Leu Arg
  50                  55                  60                  65

 ttc ctg cga gag ccc gtg gtg acg ccc cag gac ctg gag ggg ccg ggg      418
 Phe Leu Arg Glu Pro Val Val Thr Pro Gln Asp Leu Glu Gly Pro Gly
                  70                  75                  80

 cga gcc gag agc aaa gag agc gtg ggc tcc cgg gac agc tcg aag aga      466
 Arg Ala Glu Ser Lys Glu Ser Val Gly Ser Arg Asp Ser Ser Lys Arg
              85                  90                  95

 gag ggc ctc ctg gcc acc cac cct aga cct ggc cag gag cgc cct ggg      514
 Glu Gly Leu Leu Ala Thr His Pro Arg Pro Gly Gln Glu Arg Pro Gly
         100                 105                 110

 gtg gcc cgc aag gag cca gca cgg gct gag gcc cca cgc aag act gag      562
 Val Ala Arg Lys Glu Pro Ala Arg Ala Glu Ala Pro Arg Lys Thr Glu
     115                 120                 125

 aaa gaa gcc aag acc ccc cgg gag ttg aag aaa gac ccc aaa ccg agt      610
 Lys Glu Ala Lys Thr Pro Arg Glu Leu Lys Lys Asp Pro Lys Pro Ser
 130                 135                 140                 145

 gtc tcc cgg acc cag ccg cgg gag gtg cgc cgg gca gcc tct tct gtg      658
 Val Ser Arg Thr Gln Pro Arg Glu Val Arg Arg Ala Ala Ser Ser Val
                 150                 155                 160

 ccc aac ctc aag aag acg aat gcc cag gcg gca ccc aag ccc cgc aaa      706
 Pro Asn Leu Lys Lys Thr Asn Ala Gln Ala Ala Pro Lys Pro Arg Lys
             165                 170                 175

 gcg ccc agc acg tcc cac tct ggc ttc ccg ccg gtg gca aat gga ccc      754
 Ala Pro Ser Thr Ser His Ser Gly Phe Pro Pro Val Ala Asn Gly Pro
         180                 185                 190

 cgc agc ccg ccc agc ctc cga tgt gga gaa gcc agc ccc ccc agt gca      802
 Arg Ser Pro Pro Ser Leu Arg Cys Gly Glu Ala Ser Pro Pro Ser Ala
     195                 200                 205

 gcc tgc ggc tct ccg gcc tcc cag ctg gtg gcc acg ccc agc ctg gag      850
 Ala Cys Gly Ser Pro Ala Ser Gln Leu Val Ala Thr Pro Ser Leu Glu
 210                 215                 220                 225

 ctg ggg ccg atc cca gcc ggg gag gag aag gca ctg gag ctg cct ttg      898
 Leu Gly Pro Ile Pro Ala Gly Glu Glu Lys Ala Leu Glu Leu Pro Leu
                 230                 235                 240

 gcc gcc agc tca atc cca agg cca cgc aca ccc tcc cct gag tcc cac      946
 Ala Ala Ser Ser Ile Pro Arg Pro Arg Thr Pro Ser Pro Glu Ser His
             245                 250                 255

 cgg agc ccc gca gag ggc agc gag cgg ctg tcg ctg agc cca ctg cgg      994
 Arg Ser Pro Ala Glu Gly Ser Glu Arg Leu Ser Leu Ser Pro Leu Arg
         260                 265                 270

 ggc ggg gag gcc ggg cca gac gcc tca ccc aca gtg acc aca ccc acg     1042
 Gly Gly Glu Ala Gly Pro Asp Ala Ser Pro Thr Val Thr Thr Pro Thr
     275                 280                 285

 gtg acc acg ccc tca cta ccc gca gag gtg ggc tcc ccg cac tcg acc     1090
 Val Thr Thr Pro Ser Leu Pro Ala Glu Val Gly Ser Pro His Ser Thr
 290                 295                 300                 305

 gag gtg gac gag tcc ctg tcg gtg tcc ttt gag cag gtg ctg ccg cca     1138
 Glu Val Asp Glu Ser Leu Ser Val Ser Phe Glu Gln Val Leu Pro Pro
                 310                 315                 320

 tcc gcc ccc acc agt gag gct ggg ctg agc ctc ccg ctg cgt ggc ccc     1186
 Ser Ala Pro Thr Ser Glu Ala Gly Leu Ser Leu Pro Leu Arg Gly Pro
             325                 330                 335

 cgg gcg cgg cgc tcg gct tcc cca cac gat gtg gac ctg tgc ctg gtg     1234
 Arg Ala Arg Arg Ser Ala Ser Pro His Asp Val Asp Leu Cys Leu Val
         340                 345                 350

 tca ccc tgt gaa ttt gag cat cgc aag gcg gtg cca atg gca ccg gca     1282
 Ser Pro Cys Glu Phe Glu His Arg Lys Ala Val Pro Met Ala Pro Ala
     355                 360                 365

 cct gcg tcc ccc ggc agc tcg aat gac agc agt gcc cgg tca cag gaa     1330
 Pro Ala Ser Pro Gly Ser Ser Asn Asp Ser Ser Ala Arg Ser Gln Glu
 370                 375                 380                 385

 cgg gca ggt ggg ctg ggg gcc gag gag acg cca ccc aca tcg gtc agc     1378
 Arg Ala Gly Gly Leu Gly Ala Glu Glu Thr Pro Pro Thr Ser Val Ser
                 390                 395                 400

 gag tcc ctg ccc acc ctg tct gac tcg gat ccc gtg ccc ctg gcc ccc     1426
 Glu Ser Leu Pro Thr Leu Ser Asp Ser Asp Pro Val Pro Leu Ala Pro
             405                 410                 415

 ggt gcg gca gac tca gac gaa gac aca gag ggc ttt gga gtc cct cgc     1474
 Gly Ala Ala Asp Ser Asp Glu Asp Thr Glu Gly Phe Gly Val Pro Arg
         420                 425                 430

 cac gac cct ttg cct gac ccc ctc aag gtc ccc cca cca ctg cct gac     1522
 His Asp Pro Leu Pro Asp Pro Leu Lys Val Pro Pro Pro Leu Pro Asp
     435                 440                 445

 cca tcc agc atc tgc atg gtg gac ccc gag atg ctg ccc ccc aag aca     1570
 Pro Ser Ser Ile Cys Met Val Asp Pro Glu Met Leu Pro Pro Lys Thr
 450                 455                 460                 465

 gca cgg caa acg gag aac gtc agc cgc acc cgg aag ccc ctg gcc cgc     1618
 Ala Arg Gln Thr Glu Asn Val Ser Arg Thr Arg Lys Pro Leu Ala Arg
                 470                 475                 480

 ccc aac tca cgc gct gcc gcc ccc aaa gcc act cca gtg gct gct gcc     1666
 Pro Asn Ser Arg Ala Ala Ala Pro Lys Ala Thr Pro Val Ala Ala Ala
             485                 490                 495

 aaa acc aag ggg ctt gct ggt ggg gac cgt gcc agc cga cca ctc agt     1714
 Lys Thr Lys Gly Leu Ala Gly Gly Asp Arg Ala Ser Arg Pro Leu Ser
         500                 505                 510

 gcc cgg agt gag ccc agt gag aag gga ggc cgg gca ccc ctg tcc aga     1762
 Ala Arg Ser Glu Pro Ser Glu Lys Gly Gly Arg Ala Pro Leu Ser Arg
     515                 520                 525

 aag tcc tca acc ccc aag act gcc act cga ggc ccg tcg ggg tca gcc     1810
 Lys Ser Ser Thr Pro Lys Thr Ala Thr Arg Gly Pro Ser Gly Ser Ala
 530                 535                 540                 545

 agc agc cgg ccc ggg gtg tca gcc acc cca ccc aag tcc ccg gtc tac     1858
 Ser Ser Arg Pro Gly Val Ser Ala Thr Pro Pro Lys Ser Pro Val Tyr
                 550                 555                 560

 ctg gac ctg gcc tac ctg ccc agc ggg agc agc gcc cac ctg gtg gat     1906
 Leu Asp Leu Ala Tyr Leu Pro Ser Gly Ser Ser Ala His Leu Val Asp
             565                 570                 575

 gag gag ttc ttc cag cgc gtg cgc gcg ctc tgc tac gtc atc agt ggc     1954
 Glu Glu Phe Phe Gln Arg Val Arg Ala Leu Cys Tyr Val Ile Ser Gly
         580                 585                 590

 cag gac cag cgc aag gag gaa ggc atg cgg gcc gtc ctg gac gcg cta     2002
 Gln Asp Gln Arg Lys Glu Glu Gly Met Arg Ala Val Leu Asp Ala Leu
     595                 600                 605

 ctg gcc agc aag cag cat tgg gac cgt gac ctg cag gtg acc ctg atc     2050
 Leu Ala Ser Lys Gln His Trp Asp Arg Asp Leu Gln Val Thr Leu Ile
 610                 615                 620                 625

 ccc act ttc gac tcg gtg gcc atg cat acg tgg tac gca gag acg cac     2098
 Pro Thr Phe Asp Ser Val Ala Met His Thr Trp Tyr Ala Glu Thr His
                 630                 635                 640

 gcc cgg cac cag gcg ctg ggc atc acg gtg ttg ggc agc aac agc atg     2146
 Ala Arg His Gln Ala Leu Gly Ile Thr Val Leu Gly Ser Asn Ser Met
             645                 650                 655

 gtg tcc atg cag gat gac gcc ttc ccg gcc tgc aag gtg gag ttc tag     2194
 Val Ser Met Gln Asp Asp Ala Phe Pro Ala Cys Lys Val Glu Phe 
         660                 665                 670

 ccccatcgcc gacacgcccc ccactcagcc cagcccgcct gtccctagat tcagccacat   2254

 cagaaataaa ctgtgactac acttgaaaaa aaaaaaaaa                          2293




      <210> 211
      <211> 3068
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (193)..(3015)

      <400> 211
 cgggcgtccg cggtggctgc agtcccgtcg gtctccctgc tgtccggcgc gagctcttcg     60

 agtcttgctt gggatgtttc agcagcccct gagaaggaag aggaggaagc tgagggcccg    120

 ctgagggcgc aggacctgag ggagtcctac atccagctcg tccagggtgt gcaggagtgg    180

 caggatggtt gc    atg tac cag ggg gag ttt ggg ttg aac atg aag ctt     228
                  Met Tyr Gln Gly Glu Phe Gly Leu Asn Met Lys Leu
                    1               5                  10

 gga tat ggc aaa ttc tct tgg ccc aca ggc gag tca tac cat ggg cag      276
 Gly Tyr Gly Lys Phe Ser Trp Pro Thr Gly Glu Ser Tyr His Gly Gln
          15                  20                  25

 ttt tac cgg gac cac tgc cat ggc ctg ggt acc tac atg tgg cca gat      324
 Phe Tyr Arg Asp His Cys His Gly Leu Gly Thr Tyr Met Trp Pro Asp
      30                  35                  40

 ggc tcc agt ttc acg ggc aca ttt tac ctc agc cac cga gaa ggc tac      372
 Gly Ser Ser Phe Thr Gly Thr Phe Tyr Leu Ser His Arg Glu Gly Tyr
  45                  50                  55                  60

 ggc acc atg tac atg aag aca cgg ctt ttc cag ggg cta tac aaa gcg      420
 Gly Thr Met Tyr Met Lys Thr Arg Leu Phe Gln Gly Leu Tyr Lys Ala
                  65                  70                  75

 gac cag cgg ttt ggg cca ggt gtc gag acc tac ccc gat ggc agc cag      468
 Asp Gln Arg Phe Gly Pro Gly Val Glu Thr Tyr Pro Asp Gly Ser Gln
              80                  85                  90

 gac gtg ggg ctg tgg ttc cga gag cag ctc atc aag ctg tgc acc cag      516
 Asp Val Gly Leu Trp Phe Arg Glu Gln Leu Ile Lys Leu Cys Thr Gln
          95                 100                 105

 atc ccc agt ggc ttc tcc ctc ctc aga tac cct gag ttc tcc agc ttc      564
 Ile Pro Ser Gly Phe Ser Leu Leu Arg Tyr Pro Glu Phe Ser Ser Phe
     110                 115                 120

 atc acc cac agc cct gcc agg atc agc ctc tca gaa gag gag aaa acg      612
 Ile Thr His Ser Pro Ala Arg Ile Ser Leu Ser Glu Glu Glu Lys Thr
 125                 130                 135                 140

 gag tgg gga ctg cag gag gga cag gat ccc ttt ttc tat gac tat aag      660
 Glu Trp Gly Leu Gln Glu Gly Gln Asp Pro Phe Phe Tyr Asp Tyr Lys
                 145                 150                 155

 cgg ttt ctt ctg aat gac aac cta acg ctg cct cca gaa atg tat gtc      708
 Arg Phe Leu Leu Asn Asp Asn Leu Thr Leu Pro Pro Glu Met Tyr Val
             160                 165                 170

 tac tcg acc aac agt gac cac ctg ccc atg aca agc tct ttc cgc aaa      756
 Tyr Ser Thr Asn Ser Asp His Leu Pro Met Thr Ser Ser Phe Arg Lys
         175                 180                 185

 gag ctg gac gcc cgc atc ttc ctc aat gaa att cct ccg ttc gtt gag      804
 Glu Leu Asp Ala Arg Ile Phe Leu Asn Glu Ile Pro Pro Phe Val Glu
     190                 195                 200

 gat gga gaa cca tgg ttc ata atc aat gag acc cct ttg ttg gtc aaa      852
 Asp Gly Glu Pro Trp Phe Ile Ile Asn Glu Thr Pro Leu Leu Val Lys
 205                 210                 215                 220

 atc cag aag caa act tac aag ttc agg aac aag cca gct cac acc agc      900
 Ile Gln Lys Gln Thr Tyr Lys Phe Arg Asn Lys Pro Ala His Thr Ser
                 225                 230                 235

 tgg aac atg ggc gcc atc ctg gag ggg aag cgc agt ggc ttt gca ccc      948
 Trp Asn Met Gly Ala Ile Leu Glu Gly Lys Arg Ser Gly Phe Ala Pro
             240                 245                 250

 tgt ggg ccc aaa gag caa ctt tcc atg gag atg atc cta aag gct gag      996
 Cys Gly Pro Lys Glu Gln Leu Ser Met Glu Met Ile Leu Lys Ala Glu
         255                 260                 265

 gaa ggg aac cac gaa tgg att tgt agg atc ctg aag gac aac ttt gct     1044
 Glu Gly Asn His Glu Trp Ile Cys Arg Ile Leu Lys Asp Asn Phe Ala
     270                 275                 280

 agt gct gac gtg gcg gac gca aag ggc tac act gtg ctt gct gcg gct     1092
 Ser Ala Asp Val Ala Asp Ala Lys Gly Tyr Thr Val Leu Ala Ala Ala
 285                 290                 295                 300

 gct act cac tgc cac aac gac att gtc aac ctt ctc ctg gac tgt ggg     1140
 Ala Thr His Cys His Asn Asp Ile Val Asn Leu Leu Leu Asp Cys Gly
                 305                 310                 315

 gcc gac gtg aac aag tgc tca gat gag ggt ctc acg gca ctc agc atg     1188
 Ala Asp Val Asn Lys Cys Ser Asp Glu Gly Leu Thr Ala Leu Ser Met
             320                 325                 330

 tgt ttc ctc ctc cac tac ccc gcc cag tcc ttc aag ccc aat gtt gct     1236
 Cys Phe Leu Leu His Tyr Pro Ala Gln Ser Phe Lys Pro Asn Val Ala
         335                 340                 345

 gaa cgg acc ata cct gag ccc cag gaa cct cca aaa ttc cca gtt gtt     1284
 Glu Arg Thr Ile Pro Glu Pro Gln Glu Pro Pro Lys Phe Pro Val Val
     350                 355                 360

 cca atc ctt tca tca tca ttt atg gac aca aac ctg gag tct ctg tac     1332
 Pro Ile Leu Ser Ser Ser Phe Met Asp Thr Asn Leu Glu Ser Leu Tyr
 365                 370                 375                 380

 tat gag gtg aac gtg cct tcc cag ggt agc tat gag ctg agg cca ccg     1380
 Tyr Glu Val Asn Val Pro Ser Gln Gly Ser Tyr Glu Leu Arg Pro Pro
                 385                 390                 395

 cca gca cca ctg ctc ctg cca cgc gtc tca ggc agc cac gag ggc ggc     1428
 Pro Ala Pro Leu Leu Leu Pro Arg Val Ser Gly Ser His Glu Gly Gly
             400                 405                 410

 cac ttc cag gac acc ggg cag tgt ggg ggg tcc atg gac cac agg agc     1476
 His Phe Gln Asp Thr Gly Gln Cys Gly Gly Ser Met Asp His Arg Ser
         415                 420                 425

 agc tct ctg aag ggg gac tcc ccg ttg gtg aag ggc agc ctt ggc cat     1524
 Ser Ser Leu Lys Gly Asp Ser Pro Leu Val Lys Gly Ser Leu Gly His
     430                 435                 440

 gtg gaa agc ggg ctt gag gac gtg ttg gga aac aca gac cgg ggc agt     1572
 Val Glu Ser Gly Leu Glu Asp Val Leu Gly Asn Thr Asp Arg Gly Ser
 445                 450                 455                 460

 ctg tgc agt gct gag acg aaa ttt gag tcc aac gtg tgt gtg tgc gac     1620
 Leu Cys Ser Ala Glu Thr Lys Phe Glu Ser Asn Val Cys Val Cys Asp
                 465                 470                 475

 ttc tcc atc gag ctc tcg cag gcc atg ctg gag aga agc gcc cag tcc     1668
 Phe Ser Ile Glu Leu Ser Gln Ala Met Leu Glu Arg Ser Ala Gln Ser
             480                 485                 490

 cac agc ttg ctg aag atg gcc tcg ccc tca ccg tgc acc agc agc ttc     1716
 His Ser Leu Leu Lys Met Ala Ser Pro Ser Pro Cys Thr Ser Ser Phe
         495                 500                 505

 gac aaa ggg acc atg cgg agg atg gcg ctg tcc atg atc gag cgg agg     1764
 Asp Lys Gly Thr Met Arg Arg Met Ala Leu Ser Met Ile Glu Arg Arg
     510                 515                 520

 aag cgc tgg cgg acc atc aag ctg ctg ctg cgc cgg ggc gcg gac ccc     1812
 Lys Arg Trp Arg Thr Ile Lys Leu Leu Leu Arg Arg Gly Ala Asp Pro
 525                 530                 535                 540

 aac ctg tgc tgc gtg ccc atg cag gtc ctg ttc ctt gct gtg aag gcc     1860
 Asn Leu Cys Cys Val Pro Met Gln Val Leu Phe Leu Ala Val Lys Ala
                 545                 550                 555

 ggg gac gtg gat ggg gtg agg ctg ctg ctg gag cac ggg gcg agg acc     1908
 Gly Asp Val Asp Gly Val Arg Leu Leu Leu Glu His Gly Ala Arg Thr
             560                 565                 570

 gac atc tgc ttt ccg ccg cag ctg agc acc ctg aca cca ctc cac atc     1956
 Asp Ile Cys Phe Pro Pro Gln Leu Ser Thr Leu Thr Pro Leu His Ile
         575                 580                 585

 gct gcc gcc ctt cct ggg gag gag ggg gta cag att gtg gag ctg ctg     2004
 Ala Ala Ala Leu Pro Gly Glu Glu Gly Val Gln Ile Val Glu Leu Leu
     590                 595                 600

 ttg cat gcc atc acc gat gtg gac gcc aag gca tcc gac gag gac gac     2052
 Leu His Ala Ile Thr Asp Val Asp Ala Lys Ala Ser Asp Glu Asp Asp
 605                 610                 615                 620

 act tac aag ccc ggc aag ctg gac ctg ctg ccc tca agt ctg aag ctc     2100
 Thr Tyr Lys Pro Gly Lys Leu Asp Leu Leu Pro Ser Ser Leu Lys Leu
                 625                 630                 635

 agc aat gag cca ggc cct ccc caa gcc tac tac agc acg gac aca gcc     2148
 Ser Asn Glu Pro Gly Pro Pro Gln Ala Tyr Tyr Ser Thr Asp Thr Ala
             640                 645                 650

 ctc ccg gag gag ggg ggc agg acg gct ctg cac atg gcc tgc gag cgg     2196
 Leu Pro Glu Glu Gly Gly Arg Thr Ala Leu His Met Ala Cys Glu Arg
         655                 660                 665

 gag gat gac aac aag tgt gcc agg gac ata gtc cgg ctc ctt cta tcc     2244
 Glu Asp Asp Asn Lys Cys Ala Arg Asp Ile Val Arg Leu Leu Leu Ser
     670                 675                 680

 cac gga gca aat cct aac ctg ctg tgg agt ggc cac tcc ccg ctc tcc     2292
 His Gly Ala Asn Pro Asn Leu Leu Trp Ser Gly His Ser Pro Leu Ser
 685                 690                 695                 700

 ctg tcc att gcc agt ggg aat gag ctg gtt gtg aag gag ctc ctg acc     2340
 Leu Ser Ile Ala Ser Gly Asn Glu Leu Val Val Lys Glu Leu Leu Thr
                 705                 710                 715

 cag gga gct gac ccc aac ctg ccc ctg acc aaa ggc ttg ggc agt gcc     2388
 Gln Gly Ala Asp Pro Asn Leu Pro Leu Thr Lys Gly Leu Gly Ser Ala
             720                 725                 730

 ctg tgt gtt gcc tgt gac ctg acc tac gag cac cag agg aac atg gac     2436
 Leu Cys Val Ala Cys Asp Leu Thr Tyr Glu His Gln Arg Asn Met Asp
         735                 740                 745

 agc aag ctg gcc ctg att gac cga ctc atc agt cac ggg gcc gac atc     2484
 Ser Lys Leu Ala Leu Ile Asp Arg Leu Ile Ser His Gly Ala Asp Ile
     750                 755                 760

 ctg aag cct gta atg ctc agg cag gga gaa aag gag gca gtg ggc aca     2532
 Leu Lys Pro Val Met Leu Arg Gln Gly Glu Lys Glu Ala Val Gly Thr
 765                 770                 775                 780

 gcc gtg gac tat ggc tac ttc aga ttc ttc cag gac cgg agg att gcc     2580
 Ala Val Asp Tyr Gly Tyr Phe Arg Phe Phe Gln Asp Arg Arg Ile Ala
                 785                 790                 795

 cgc tgc ccc ttc cac acg ctg atg cca gca gag cgc gag acg ttc ctg     2628
 Arg Cys Pro Phe His Thr Leu Met Pro Ala Glu Arg Glu Thr Phe Leu
             800                 805                 810

 gcg cgg aag cgg ctc ctg gag tac atg ggc ttg cag cta cgg cag gct     2676
 Ala Arg Lys Arg Leu Leu Glu Tyr Met Gly Leu Gln Leu Arg Gln Ala
         815                 820                 825

 gtc ttt gcc aag gag agc cag tgg gac ccc acg tgg ctg tac ctg tgc     2724
 Val Phe Ala Lys Glu Ser Gln Trp Asp Pro Thr Trp Leu Tyr Leu Cys
     830                 835                 840

 aag aga gcg gag ctg atc ccc agc cac agg atg aag aag aag ggc ccc     2772
 Lys Arg Ala Glu Leu Ile Pro Ser His Arg Met Lys Lys Lys Gly Pro
 845                 850                 855                 860

 agc ctg ccc agg ggc ctg gat gtg aag gag cag ggg caa att ccc ttc     2820
 Ser Leu Pro Arg Gly Leu Asp Val Lys Glu Gln Gly Gln Ile Pro Phe
                 865                 870                 875

 ttc aag ttc tgc tac cag tgt ggc cgc tcc atc ggg gtc cgc ctc ttg     2868
 Phe Lys Phe Cys Tyr Gln Cys Gly Arg Ser Ile Gly Val Arg Leu Leu
             880                 885                 890

 ccc tgc cct cgc tgc tac ggg atc ctg acc tgc agc aag tac tgc aag     2916
 Pro Cys Pro Arg Cys Tyr Gly Ile Leu Thr Cys Ser Lys Tyr Cys Lys
         895                 900                 905

 acc aag gcc tgg acc gag ttc cac aag aag gac tgc ggg gac ctg gtg     2964
 Thr Lys Ala Trp Thr Glu Phe His Lys Lys Asp Cys Gly Asp Leu Val
     910                 915                 920

 gcc atc gtg aca caa ctg gag caa gtt tcc agg agg aga gaa gaa ttc     3012
 Ala Ile Val Thr Gln Leu Glu Gln Val Ser Arg Arg Arg Glu Glu Phe
 925                 930                 935                 940

 cag tgaagcagca gctgcacgtc cgaggcttgg ggaggaccca ggactgtgtg ggt      3068
 Gln 






      <210> 212
      <211> 4285
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (20)..(4096)

      <400> 212
 agctcagaag ccctcccac atg aga aga aac ata cga aag cta ctc cgg gag      52
                      Met Arg Arg Asn Ile Arg Lys Leu Leu Arg Glu
                        1               5                  10

 gat caa ttg gag cct gtt acc aaa gca gca cag caa gaa gag ttg gaa      100
 Asp Gln Leu Glu Pro Val Thr Lys Ala Ala Gln Gln Glu Glu Leu Glu
              15                  20                  25

 aga agg aag cgc ctg gag cag cag agg aaa gat tat gca gcc cct att      148
 Arg Arg Lys Arg Leu Glu Gln Gln Arg Lys Asp Tyr Ala Ala Pro Ile
          30                  35                  40

 cct act gtt ccg ctg gag ttc ctc cct gag gaa att gct tta agg gca      196
 Pro Thr Val Pro Leu Glu Phe Leu Pro Glu Glu Ile Ala Leu Arg Ala
      45                  50                  55

 agt gac ggt ccc caa ctg cct cct cgg gtc ttg gcc cag gaa gtc att      244
 Ser Asp Gly Pro Gln Leu Pro Pro Arg Val Leu Ala Gln Glu Val Ile
  60                  65                  70                  75

 tgt ttg gac agt agc agt ggc agt gag gat gaa aaa agc agt cga gat      292
 Cys Leu Asp Ser Ser Ser Gly Ser Glu Asp Glu Lys Ser Ser Arg Asp
                  80                  85                  90

 gag gtg att gaa ctg agc tct gga gag gag gac act ctg cac att gtg      340
 Glu Val Ile Glu Leu Ser Ser Gly Glu Glu Asp Thr Leu His Ile Val
              95                 100                 105

 gac agc agt gaa tct gtc agt gaa gat gat gag gaa gaa gag aag ggt      388
 Asp Ser Ser Glu Ser Val Ser Glu Asp Asp Glu Glu Glu Glu Lys Gly
         110                 115                 120

 ggc acc cat gtc aat gat gtc tta aac cag cgt gac gcc ctt ggg cgg      436
 Gly Thr His Val Asn Asp Val Leu Asn Gln Arg Asp Ala Leu Gly Arg
     125                 130                 135

 gtc ctt gtc aac cta aac cac cct cca gag gag gaa aat gtc ttc ctt      484
 Val Leu Val Asn Leu Asn His Pro Pro Glu Glu Glu Asn Val Phe Leu
 140                 145                 150                 155

 gcc cca cag ttg gca cgg gct gtg aaa cct cat cag att ggc ggg atc      532
 Ala Pro Gln Leu Ala Arg Ala Val Lys Pro His Gln Ile Gly Gly Ile
                 160                 165                 170

 cgg ttc ctt tac gat aac cta gtg gag tct ctg gag agg ttt aag acc      580
 Arg Phe Leu Tyr Asp Asn Leu Val Glu Ser Leu Glu Arg Phe Lys Thr
             175                 180                 185

 agc agt ggc ttt ggc tgt att ctg gcc cac agc atg ggt ctg ggg aaa      628
 Ser Ser Gly Phe Gly Cys Ile Leu Ala His Ser Met Gly Leu Gly Lys
         190                 195                 200

 act ttg caa gtg atc tct ttc atc gac gtc ctc ttc cgc cac acg cca      676
 Thr Leu Gln Val Ile Ser Phe Ile Asp Val Leu Phe Arg His Thr Pro
     205                 210                 215

 gcc aaa aca gtc ctt gcc att gtg ccg gtt aat act ctt cag aat tgg      724
 Ala Lys Thr Val Leu Ala Ile Val Pro Val Asn Thr Leu Gln Asn Trp
 220                 225                 230                 235

 ctg gca gag ttc aac atg tgg ctt cca cct cct gaa gcc ctc ccg gct      772
 Leu Ala Glu Phe Asn Met Trp Leu Pro Pro Pro Glu Ala Leu Pro Ala
                 240                 245                 250

 gac aac aag cct gaa gaa gtc cag cct cgg ttc ttt aaa gtt cac atc      820
 Asp Asn Lys Pro Glu Glu Val Gln Pro Arg Phe Phe Lys Val His Ile
             255                 260                 265

 ttg aat gat gag cac aag acg atg gca tct cgt gct aaa gtg atg gct      868
 Leu Asn Asp Glu His Lys Thr Met Ala Ser Arg Ala Lys Val Met Ala
         270                 275                 280

 gat tgg gtg tca gag ggt ggc gtg ctg ctg atg ggg tac gag atg tac      916
 Asp Trp Val Ser Glu Gly Gly Val Leu Leu Met Gly Tyr Glu Met Tyr
     285                 290                 295

 aga ctc ctc act ctg aag aaa tca ttt gcc aca ggt aga ccg aag aaa      964
 Arg Leu Leu Thr Leu Lys Lys Ser Phe Ala Thr Gly Arg Pro Lys Lys
 300                 305                 310                 315

 acc aag aag cgt tct cac cca gtc atc att gat cta gat gag gaa gat     1012
 Thr Lys Lys Arg Ser His Pro Val Ile Ile Asp Leu Asp Glu Glu Asp
                 320                 325                 330

 cgg cag cag gag ttt cgg aga gag ttt gag aag gct tta tgc cgc cct     1060
 Arg Gln Gln Glu Phe Arg Arg Glu Phe Glu Lys Ala Leu Cys Arg Pro
             335                 340                 345

 ggc cct gat gta gta atc tgt gat gag gga cac cgc atc aaa aac tgc     1108
 Gly Pro Asp Val Val Ile Cys Asp Glu Gly His Arg Ile Lys Asn Cys
         350                 355                 360

 cag gcc agc acc tca cag gct ctg aag aat atc cgc tct cgc cgc cgg     1156
 Gln Ala Ser Thr Ser Gln Ala Leu Lys Asn Ile Arg Ser Arg Arg Arg
     365                 370                 375

 gtg gtg ctg act ggg tac cct ctg caa aac aac ctc att gag tac tgg     1204
 Val Val Leu Thr Gly Tyr Pro Leu Gln Asn Asn Leu Ile Glu Tyr Trp
 380                 385                 390                 395

 tgc atg gtg gac ttt gtg cgc cca gac ttc ctt ggc acc cgg cag gag     1252
 Cys Met Val Asp Phe Val Arg Pro Asp Phe Leu Gly Thr Arg Gln Glu
                 400                 405                 410

 ttc agc aac atg ttt gaa cgc cct atc ctg aat ggg caa tgt att gac     1300
 Phe Ser Asn Met Phe Glu Arg Pro Ile Leu Asn Gly Gln Cys Ile Asp
             415                 420                 425

 agc aca cct cag gac gtc cgc ctc atg cgg tac cgg agc cat gtc ctg     1348
 Ser Thr Pro Gln Asp Val Arg Leu Met Arg Tyr Arg Ser His Val Leu
         430                 435                 440

 cac agt ctt ctg gag ggc ttt gtg cag agg aga ggc cac act gtg ctg     1396
 His Ser Leu Leu Glu Gly Phe Val Gln Arg Arg Gly His Thr Val Leu
     445                 450                 455

 aag att cat ctc cct gcc aag gaa gaa aat gtg atc ctt gtg cgg ctc     1444
 Lys Ile His Leu Pro Ala Lys Glu Glu Asn Val Ile Leu Val Arg Leu
 460                 465                 470                 475

 tcc aag atc cag cga gat ttg tat aca cag ttc atg gat cgc ttc cgg     1492
 Ser Lys Ile Gln Arg Asp Leu Tyr Thr Gln Phe Met Asp Arg Phe Arg
                 480                 485                 490

 gac tgt ggt agc agc ggt tgg ctg ggg ctg aac ccc ctt aag gca ttc     1540
 Asp Cys Gly Ser Ser Gly Trp Leu Gly Leu Asn Pro Leu Lys Ala Phe
             495                 500                 505

 tgt gtg tgt tgc aag atc tgg aat cac cct gat gtg ctg tat gaa gcc     1588
 Cys Val Cys Cys Lys Ile Trp Asn His Pro Asp Val Leu Tyr Glu Ala
         510                 515                 520

 ctt cag aag gag agc ttg gcc aat gag cag gac cta gac gtg gaa gaa     1636
 Leu Gln Lys Glu Ser Leu Ala Asn Glu Gln Asp Leu Asp Val Glu Glu
     525                 530                 535

 ctt ggc tct gca ggg acc agt gcc cgc tgt cca cca cag gga aca aaa     1684
 Leu Gly Ser Ala Gly Thr Ser Ala Arg Cys Pro Pro Gln Gly Thr Lys
 540                 545                 550                 555

 ggc aag gga gag gat agc acc ttg gct tcc tcg atg gga gag gca acc     1732
 Gly Lys Gly Glu Asp Ser Thr Leu Ala Ser Ser Met Gly Glu Ala Thr
                 560                 565                 570

 aat agc aag ttc cta cag ggc gtt ggc ttc aac cct ttc cag gag cga     1780
 Asn Ser Lys Phe Leu Gln Gly Val Gly Phe Asn Pro Phe Gln Glu Arg
             575                 580                 585

 ggc aac aac att gtc aca tat gaa tgg gcc aag gac ctt ctg act aat     1828
 Gly Asn Asn Ile Val Thr Tyr Glu Trp Ala Lys Asp Leu Leu Thr Asn
         590                 595                 600

 tac cag act gga gtc cta gaa aac tct ccc aag atg gta ctg ctt ttc     1876
 Tyr Gln Thr Gly Val Leu Glu Asn Ser Pro Lys Met Val Leu Leu Phe
     605                 610                 615

 cac ctg att gag gaa agt gtg aag ctt ggg gac aag atc ctt gtg ttt     1924
 His Leu Ile Glu Glu Ser Val Lys Leu Gly Asp Lys Ile Leu Val Phe
 620                 625                 630                 635

 agc cag agt ctt tcc acc ttg gct ctc atc gag gaa ttc ctt gga aaa     1972
 Ser Gln Ser Leu Ser Thr Leu Ala Leu Ile Glu Glu Phe Leu Gly Lys
                 640                 645                 650

 cga gaa gta ccc tgt cca cct ggt acc gag ggg caa gga gca cag aag     2020
 Arg Glu Val Pro Cys Pro Pro Gly Thr Glu Gly Gln Gly Ala Gln Lys
             655                 660                 665

 tgg gtt cga aac atc agc tac ttc cgg cta gat ggt agc acc cct gcc     2068
 Trp Val Arg Asn Ile Ser Tyr Phe Arg Leu Asp Gly Ser Thr Pro Ala
         670                 675                 680

 ttt gag agg gag cgg ctt att aat cag ttc aat gat ccc agc aac ctc     2116
 Phe Glu Arg Glu Arg Leu Ile Asn Gln Phe Asn Asp Pro Ser Asn Leu
     685                 690                 695

 acc acc tgg ctg ttc ctt ctc tct aca agg gcc gga tgc ttg ggt gtg     2164
 Thr Thr Trp Leu Phe Leu Leu Ser Thr Arg Ala Gly Cys Leu Gly Val
 700                 705                 710                 715

 aat ctg att ggt gcc aac cga gtg gtg gtg ttt gat gct tcc tgg aac     2212
 Asn Leu Ile Gly Ala Asn Arg Val Val Val Phe Asp Ala Ser Trp Asn
                 720                 725                 730

 cct tgc cat gat gcc cag gca gta tgt cgg gta tac cgt tat ggc cag     2260
 Pro Cys His Asp Ala Gln Ala Val Cys Arg Val Tyr Arg Tyr Gly Gln
             735                 740                 745

 aaa aag ccc tgt tac atc tat cgc ctt gtg gct gat tac act cta gaa     2308
 Lys Lys Pro Cys Tyr Ile Tyr Arg Leu Val Ala Asp Tyr Thr Leu Glu
         750                 755                 760

 aag aag atc tat gac cgt cag att tcc aag cag ggc atg tca gat cgg     2356
 Lys Lys Ile Tyr Asp Arg Gln Ile Ser Lys Gln Gly Met Ser Asp Arg
     765                 770                 775

 gtg gtg gat gat cta aat cca atg ctg aac ttc aca cgg aaa gag gtg     2404
 Val Val Asp Asp Leu Asn Pro Met Leu Asn Phe Thr Arg Lys Glu Val
 780                 785                 790                 795

 gaa aac cta ctg cac ttt gtt gag aag gag cca gct ccc caa gtt tcc     2452
 Glu Asn Leu Leu His Phe Val Glu Lys Glu Pro Ala Pro Gln Val Ser
                 800                 805                 810

 ttg aac gta aag ggg atc aag gag tca gtc ctg caa ctg gcc tgt ctg     2500
 Leu Asn Val Lys Gly Ile Lys Glu Ser Val Leu Gln Leu Ala Cys Leu
             815                 820                 825

 aag tac cct cac ctc atc acc aag gag cct ttc gag cat gag tca ttg     2548
 Lys Tyr Pro His Leu Ile Thr Lys Glu Pro Phe Glu His Glu Ser Leu
         830                 835                 840

 ctc ttg aac cga aag gat cac aag cta acc aag gct gag aaa aaa gca     2596
 Leu Leu Asn Arg Lys Asp His Lys Leu Thr Lys Ala Glu Lys Lys Ala
     845                 850                 855

 gca aag aaa agc tat gag gaa gac aaa cgc aca tca gtc ccc tat acc     2644
 Ala Lys Lys Ser Tyr Glu Glu Asp Lys Arg Thr Ser Val Pro Tyr Thr
 860                 865                 870                 875

 cgc cca tcg tat gcg cag tat tac cct gcc agc gat cag agc ctg acc     2692
 Arg Pro Ser Tyr Ala Gln Tyr Tyr Pro Ala Ser Asp Gln Ser Leu Thr
                 880                 885                 890

 agc atc ccc gcc ttc agc cag aga aac tgg cag cca act ttg aag ggg     2740
 Ser Ile Pro Ala Phe Ser Gln Arg Asn Trp Gln Pro Thr Leu Lys Gly
             895                 900                 905

 gat gaa aag cct gtg gcc agt gtt cgt cct gtg cag tcc acc ccc atc     2788
 Asp Glu Lys Pro Val Ala Ser Val Arg Pro Val Gln Ser Thr Pro Ile
         910                 915                 920

 ccc atg atg ccc cgg cat gtc cca ttg gga gga agt gta agc tct gcc     2836
 Pro Met Met Pro Arg His Val Pro Leu Gly Gly Ser Val Ser Ser Ala
     925                 930                 935

 tcc agc aca aat cca tcc atg aac ttt ccc atc aac tac ttg cag cgt     2884
 Ser Ser Thr Asn Pro Ser Met Asn Phe Pro Ile Asn Tyr Leu Gln Arg
 940                 945                 950                 955

 gca gga gtc ctt gtg cag aag gtg gtc acc acg aca gat att gtt att     2932
 Ala Gly Val Leu Val Gln Lys Val Val Thr Thr Thr Asp Ile Val Ile
                 960                 965                 970

 cct gga ctc aac agc tcc aca gat gta cag gca aga att aat gct ggt     2980
 Pro Gly Leu Asn Ser Ser Thr Asp Val Gln Ala Arg Ile Asn Ala Gly
             975                 980                 985

 gag agc atc cac atc atc cgt ggg aca aaa ggg acg tac atc cgt acc     3028
 Glu Ser Ile His Ile Ile Arg Gly Thr Lys Gly Thr Tyr Ile Arg Thr
         990                 995                1000

 agt gat gga cgg atc ttt gct gtc cgg gca act ggc aaa cca aag gtt     3076
 Ser Asp Gly Arg Ile Phe Ala Val Arg Ala Thr Gly Lys Pro Lys Val
    1005                1010                1015

 cct gaa gat ggt cgg atg gct gcc tca ggt tcc cag gga cct tct tgc     3124
 Pro Glu Asp Gly Arg Met Ala Ala Ser Gly Ser Gln Gly Pro Ser Cys
1020                1025                1030                1035

 gag tcc aca agc aac ggc aga cac agt gcc tca tca ccc aaa gcc ccc     3172
 Glu Ser Thr Ser Asn Gly Arg His Ser Ala Ser Ser Pro Lys Ala Pro
                1040                1045                1050

 gac cct gag ggg ctg gcc agg ccc gtc tct cct gac agc cca gag atc     3220
 Asp Pro Glu Gly Leu Ala Arg Pro Val Ser Pro Asp Ser Pro Glu Ile
            1055                1060                1065

 atc agt gag ctt cag cag tat gca gat gtg gct gct gcc cgg gaa tcc     3268
 Ile Ser Glu Leu Gln Gln Tyr Ala Asp Val Ala Ala Ala Arg Glu Ser
        1070                1075                1080

 cgt cag agc tcc cca agc acc aat gcc gcc ctg cct ggc ccc ccg gcc     3316
 Arg Gln Ser Ser Pro Ser Thr Asn Ala Ala Leu Pro Gly Pro Pro Ala
    1085                1090                1095

 caa ctt atg gac agc agt gct gtt ccc ggg aca gct ctc gga act gag     3364
 Gln Leu Met Asp Ser Ser Ala Val Pro Gly Thr Ala Leu Gly Thr Glu
1100                1105                1110                1115

 cct cga cta ggg ggt cat tgc ctc aat agt tcc ctc ttg gtg act ggc     3412
 Pro Arg Leu Gly Gly His Cys Leu Asn Ser Ser Leu Leu Val Thr Gly
                1120                1125                1130

 cag ccc tgt ggt gac agg cac cca gtg ctg gac tta agg ggc cac aag     3460
 Gln Pro Cys Gly Asp Arg His Pro Val Leu Asp Leu Arg Gly His Lys
            1135                1140                1145

 cga aag ttg gcc aca cca cct gct gcc cag gag tca tcc cgc cgg cgg     3508
 Arg Lys Leu Ala Thr Pro Pro Ala Ala Gln Glu Ser Ser Arg Arg Arg
        1150                1155                1160

 tcc agg aag ggt cat ctg cca gcc ccc gtg cag ccg tat gaa cac ggg     3556
 Ser Arg Lys Gly His Leu Pro Ala Pro Val Gln Pro Tyr Glu His Gly
    1165                1170                1175

 tat cca gtc tct ggc ggg ttt gcc atg cca ccc gtc tcc tta aac cat     3604
 Tyr Pro Val Ser Gly Gly Phe Ala Met Pro Pro Val Ser Leu Asn His
1180                1185                1190                1195

 aac ctc acc acc ccc ttc acc tcc cag gct ggg gag aac tcc ctg ttt     3652
 Asn Leu Thr Thr Pro Phe Thr Ser Gln Ala Gly Glu Asn Ser Leu Phe
                1200                1205                1210

 atg ggc agt acc ccc tcc tac tac cag ctg tcc aat ttg ctg gca gat     3700
 Met Gly Ser Thr Pro Ser Tyr Tyr Gln Leu Ser Asn Leu Leu Ala Asp
            1215                1220                1225

 gcc cgc ctg gtg ttt cca gtg act act gac cct ctg gtg cca gca ggc     3748
 Ala Arg Leu Val Phe Pro Val Thr Thr Asp Pro Leu Val Pro Ala Gly
        1230                1235                1240

 ccc gtc agt tcc tct tcc acg gct acc tca gtc act gcc agc aac ccc     3796
 Pro Val Ser Ser Ser Ser Thr Ala Thr Ser Val Thr Ala Ser Asn Pro
    1245                1250                1255

 tcc ttc atg ctc aac cct tct gtg cca ggg ata cta ccc agc tat tca     3844
 Ser Phe Met Leu Asn Pro Ser Val Pro Gly Ile Leu Pro Ser Tyr Ser
1260                1265                1270                1275

 ctc cca ttc tca cag cca ctc ctg tcc gag ccg agg atg ttt gcg cct     3892
 Leu Pro Phe Ser Gln Pro Leu Leu Ser Glu Pro Arg Met Phe Ala Pro
                1280                1285                1290

 ttt cct tcc cct gtc ttg ccc agc aac ctt tcg cgg ggc atg tct atc     3940
 Phe Pro Ser Pro Val Leu Pro Ser Asn Leu Ser Arg Gly Met Ser Ile
            1295                1300                1305

 tat cca ggc tac atg tcc cca cat gca ggc tac cca gct ggt ggc ctc     3988
 Tyr Pro Gly Tyr Met Ser Pro His Ala Gly Tyr Pro Ala Gly Gly Leu
        1310                1315                1320

 cta cgg tcc cag gtg cct cca ttt gac tct cat gag gtt gcc gag gtt     4036
 Leu Arg Ser Gln Val Pro Pro Phe Asp Ser His Glu Val Ala Glu Val
    1325                1330                1335

 ggg ttc agc tcc aat gat gat gag gat aaa gac gat gat gtg ata gag     4084
 Gly Phe Ser Ser Asn Asp Asp Glu Asp Lys Asp Asp Asp Val Ile Glu
1340                1345                1350                1355

 gtc act ggg aaa tag ctagggagcc cctccccacc tcacttgggg cccccagcag     4139
 Val Thr Gly Lys 


 gttgcccacc aagctggaag gcagtgattt agaccttttg agaataggac acttggcagg   4199

 agggaaaagg aagaggacaa aggagggtgg ttggccaaag tggcagagct ctgttgctgt   4259

 ttaacaaaag aggcaaaaaa aaaaaa                                        4285




      <210> 213
      <211> 1547
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (267)..(938)

      <400> 213
 tttgcgctcg gggaattaaa agaggggaaa aaaagcccga agaaaactca cgccccaaac     60

 aaaacgcaag gagaggaggg cgcgcggcct gcagccctcg cccgcgtccc cggccgcggc    120

 gtgatgcgcg cggaccagcc cgcgacgccc gggctgccgc tgtccccgca cctggacgct    180

 ggcgcggtgg ccgcgcccca gcctcgatcg ctcgccgcgg cgactcggcc ccaggcttcc    240

 ggcgccggtg ggggccctcg ctctcc atg ggg ctg agg gac tgg ctg aga acc     293
                              Met Gly Leu Arg Asp Trp Leu Arg Thr
                                1               5

 gtg tgc tgc tgc tgc cgg tgc gag tgc ttg gag gag cgc gcc ctg cct      341
 Val Cys Cys Cys Cys Arg Cys Glu Cys Leu Glu Glu Arg Ala Leu Pro
  10                  15                  20                  25

 gag aag gag ccc ctc gtc agt gat aac aat cca tat tcc tca ttt gga      389
 Glu Lys Glu Pro Leu Val Ser Asp Asn Asn Pro Tyr Ser Ser Phe Gly
                  30                  35                  40

 gca act ctg gtg agg gat gat gag aag aat tta tgg agt atg ccc cat      437
 Ala Thr Leu Val Arg Asp Asp Glu Lys Asn Leu Trp Ser Met Pro His
              45                  50                  55

 gat gtg tcc cac aca gag gca gac gac gac aga acc ctg tac aat ttg      485
 Asp Val Ser His Thr Glu Ala Asp Asp Asp Arg Thr Leu Tyr Asn Leu
          60                  65                  70

 ata gtc att cgt aat cag cag gcc aaa gac tca gag gag tgg cag aag      533
 Ile Val Ile Arg Asn Gln Gln Ala Lys Asp Ser Glu Glu Trp Gln Lys
      75                  80                  85

 ctc aac tat gat atc cat acc ctg cgg cag gtt cga agg gaa gta aga      581
 Leu Asn Tyr Asp Ile His Thr Leu Arg Gln Val Arg Arg Glu Val Arg
  90                  95                 100                 105

 aac aga tgg aag tgc atc tta gaa gat tta ggt ttt caa aag gaa gct      629
 Asn Arg Trp Lys Cys Ile Leu Glu Asp Leu Gly Phe Gln Lys Glu Ala
                 110                 115                 120

 gac tct ttg ttg tca gtg act aaa ctc agc acc atc agt gat tct aaa      677
 Asp Ser Leu Leu Ser Val Thr Lys Leu Ser Thr Ile Ser Asp Ser Lys
             125                 130                 135

 aac aca agg aaa gct cga gag atg ttg tta aaa ctg gct gaa gaa acc      725
 Asn Thr Arg Lys Ala Arg Glu Met Leu Leu Lys Leu Ala Glu Glu Thr
         140                 145                 150

 agt att ttc cca aca agt tgg gag ctc tca gag aga tat ctc ttt gtt      773
 Ser Ile Phe Pro Thr Ser Trp Glu Leu Ser Glu Arg Tyr Leu Phe Val
     155                 160                 165

 gtg gac cgt ctc att gca ctt gat gct gca gaa gag ttc ttt aag ctt      821
 Val Asp Arg Leu Ile Ala Leu Asp Ala Ala Glu Glu Phe Phe Lys Leu
 170                 175                 180                 185

 gct cgt cga act tac ccc aag aag cct ggg gtt cca tgc ctg gca gat      869
 Ala Arg Arg Thr Tyr Pro Lys Lys Pro Gly Val Pro Cys Leu Ala Asp
                 190                 195                 200

 ggc cag aaa gaa ctg cac ctg tgg ggg gac ctc tca tgc aga ctt gca      917
 Gly Gln Lys Glu Leu His Leu Trp Gly Asp Leu Ser Cys Arg Leu Ala
             205                 210                 215

 cat atg cag gga gta ttg cac tg aagatctttg ctggaccttc ttctcttcag      970
 His Met Gln Gly Val Leu His 
         220

 aagataattt tcaaaaggga gcaatgctgt gaatgcagct tgcttctctc tacagattga   1030

 gaagtccagc ttcaaaagtt acttgccact taagcaagga acttgtcaag agatcatggt   1090

 tcatgttact gaaaagactt taaggatttg taaggttaat ccatagattg ctgagaacaa   1150

 tggaaatatt tttattttta cagattttgc acttctgaat tcaggttaaa aactaacttg   1210

 tatttagtct gcttagagga ctgtgacttg aaaattttta tataccaatg agctttttgg   1270

 tagcgtccac aatgtttaaa atatttcata ggcgagatcc gtgttctcca tttattaatg   1330

 cattgtagac caatttaact gctgtgtttc aggaaaattc ttcctagttt aataagcaag   1390

 ctaaaagttt tattttttat atttagtgct taatctttgc ctcatgttat gtaaaattag   1450

 cctgcagata ttttctctca attctgtaga ctctcgcaag ataaacattc aaacagtgaa   1510

 acaaacaata aaataaataa acctaaaaaa aaaaaaa                            1547




      <210> 214
      <211> 2320
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (323)..(1813)

      <400> 214
 ccgctccccg ctgtccccca gcttactcca atcaagcctc tgcccgccag gaacaggtaa     60

 cctgtgtgtg tccgtttgct ccttctaaga gcatgcctga tagatacttc ggtagcctct    120

 ccggatggcc ccttcgtcgg gtagcctctc ctgatggggt ccttcgccca ccctgcctcc    180

 cgcgccgggc tccgggtgaa tgtcaagggt ggctggctgc gaatacctcc ttcagctgct    240

 ggggttcccg acagtttgca gtttttaaaa gtgcaccctc ggaagggctt ttcagactgg    300

 gtaaacctga cttttccaag ag atg gca gat cct gag gta gtt gtg agt agc     352
                          Met Ala Asp Pro Glu Val Val Val Ser Ser
                            1               5                  10

 tgc agc tct cat gaa gag gaa aat cgc tgc aat ttt aac cag caa aca      400
 Cys Ser Ser His Glu Glu Glu Asn Arg Cys Asn Phe Asn Gln Gln Thr
                  15                  20                  25

 tct cca tct gag gag ctt cta tta gaa gac cag atg agg cga aaa ctc      448
 Ser Pro Ser Glu Glu Leu Leu Leu Glu Asp Gln Met Arg Arg Lys Leu
              30                  35                  40

 aaa ttt ttt ttc atg aat ccc tgt gag aag ttc tgg gct cga ggt aga      496
 Lys Phe Phe Phe Met Asn Pro Cys Glu Lys Phe Trp Ala Arg Gly Arg
          45                  50                  55

 aaa cca tgg aaa ctt gcc ata caa att cta aaa att gca atg gtg act      544
 Lys Pro Trp Lys Leu Ala Ile Gln Ile Leu Lys Ile Ala Met Val Thr
      60                  65                  70

 atc cag tac ttg cag cta tac aat gtc tcc gtt ggg aat cat gct tat      592
 Ile Gln Tyr Leu Gln Leu Tyr Asn Val Ser Val Gly Asn His Ala Tyr
  75                  80                  85                  90

 gag aac aaa ggt acc aag caa tct gct atg gca atc tgt cag cac ttc      640
 Glu Asn Lys Gly Thr Lys Gln Ser Ala Met Ala Ile Cys Gln His Phe
                  95                 100                 105

 tac aag cga gga aac atc tac cct gga aat gat acc ttt gac atc gat      688
 Tyr Lys Arg Gly Asn Ile Tyr Pro Gly Asn Asp Thr Phe Asp Ile Asp
             110                 115                 120

 cca gaa att gaa act gag tgt ttc ttt gtg gag cca gat gaa cct ttt      736
 Pro Glu Ile Glu Thr Glu Cys Phe Phe Val Glu Pro Asp Glu Pro Phe
         125                 130                 135

 cac att ggg aca cca gca gaa aat aaa ctg aac tta aca ctg gac ttc      784
 His Ile Gly Thr Pro Ala Glu Asn Lys Leu Asn Leu Thr Leu Asp Phe
     140                 145                 150

 cac aga ctc cta aca gtg gag ctt cag ttt aaa ctg aaa gcc att aat      832
 His Arg Leu Leu Thr Val Glu Leu Gln Phe Lys Leu Lys Ala Ile Asn
 155                 160                 165                 170

 ctg cag aca gtt cgt cat caa gaa ctc cct gac tgt tat gac ttt act      880
 Leu Gln Thr Val Arg His Gln Glu Leu Pro Asp Cys Tyr Asp Phe Thr
                 175                 180                 185

 ctg act ata aca ttt gac aac aag gcc cat agt gga aga att aaa ata      928
 Leu Thr Ile Thr Phe Asp Asn Lys Ala His Ser Gly Arg Ile Lys Ile
             190                 195                 200

 agt tta gat aat gac att tcc atc aga gaa tgt aaa gac tgg cat gta      976
 Ser Leu Asp Asn Asp Ile Ser Ile Arg Glu Cys Lys Asp Trp His Val
         205                 210                 215

 tct gga tca att cag aag aac act cat tac atg atg atc ttt gat gcc     1024
 Ser Gly Ser Ile Gln Lys Asn Thr His Tyr Met Met Ile Phe Asp Ala
     220                 225                 230

 ttt gtc att ctg act tgc ttg gtt tca tta atc ctc tgc att aga tct     1072
 Phe Val Ile Leu Thr Cys Leu Val Ser Leu Ile Leu Cys Ile Arg Ser
 235                 240                 245                 250

 gtg att aga gga ctt cag ctt cag cag gag ttt gtc aat ttt ttc ctc     1120
 Val Ile Arg Gly Leu Gln Leu Gln Gln Glu Phe Val Asn Phe Phe Leu
                 255                 260                 265

 ctc cat tat aag aag gaa gtt tct gtt tct gat caa atg gaa ttt gtc     1168
 Leu His Tyr Lys Lys Glu Val Ser Val Ser Asp Gln Met Glu Phe Val
             270                 275                 280

 aat gga tgg tac att atg att att att agt gac ata ttg aca atc att     1216
 Asn Gly Trp Tyr Ile Met Ile Ile Ile Ser Asp Ile Leu Thr Ile Ile
         285                 290                 295

 gga tca att cta aaa atg gaa atc caa gct aag agt cta act agt tat     1264
 Gly Ser Ile Leu Lys Met Glu Ile Gln Ala Lys Ser Leu Thr Ser Tyr
     300                 305                 310

 gat gtc tgt agc ata ctt ctt ggg act tct acc atg ctc gtg tgg ctt     1312
 Asp Val Cys Ser Ile Leu Leu Gly Thr Ser Thr Met Leu Val Trp Leu
 315                 320                 325                 330

 gga gtc atc cga tac ctc ggt ttc ttt gca aag tac aac ctc ctc att     1360
 Gly Val Ile Arg Tyr Leu Gly Phe Phe Ala Lys Tyr Asn Leu Leu Ile
                 335                 340                 345

 ttg acc ctt cag gca gcg ctg ccc aat gtc atc agg ttc tgc tgc tgt     1408
 Leu Thr Leu Gln Ala Ala Leu Pro Asn Val Ile Arg Phe Cys Cys Cys
             350                 355                 360

 gca gct atg att tac tta ggt tac tgc ttc tgt gga tgg atc gtg ctg     1456
 Ala Ala Met Ile Tyr Leu Gly Tyr Cys Phe Cys Gly Trp Ile Val Leu
         365                 370                 375

 ggg cct tac cat gac aag ttt cgt tct ctg aac atg gtc tct gag tgc     1504
 Gly Pro Tyr His Asp Lys Phe Arg Ser Leu Asn Met Val Ser Glu Cys
     380                 385                 390

 ctt ttc tct ctg ata aat gga gat gat atg ttt gcc acg ttt gca aaa     1552
 Leu Phe Ser Leu Ile Asn Gly Asp Asp Met Phe Ala Thr Phe Ala Lys
 395                 400                 405                 410

 atg cag caa aaa agt tac tta gtc tgg ctg ttt agt aga att tac ctc     1600
 Met Gln Gln Lys Ser Tyr Leu Val Trp Leu Phe Ser Arg Ile Tyr Leu
                 415                 420                 425

 tac tca ttc atc agc ctc ttt ata tat atg att tta agt ctt ttc att     1648
 Tyr Ser Phe Ile Ser Leu Phe Ile Tyr Met Ile Leu Ser Leu Phe Ile
             430                 435                 440

 gca ctg atc act gat aca tac gaa aca att aag caa tac caa caa gat     1696
 Ala Leu Ile Thr Asp Thr Tyr Glu Thr Ile Lys Gln Tyr Gln Gln Asp
         445                 450                 455

 ggc ttc cca gag act gaa ctt cgt aca ttt ata tca gaa tgc aaa gat     1744
 Gly Phe Pro Glu Thr Glu Leu Arg Thr Phe Ile Ser Glu Cys Lys Asp
     460                 465                 470

 cta ccc aac tct gga aaa tac aga tta gaa gat gac cct cca gta tct     1792
 Leu Pro Asn Ser Gly Lys Tyr Arg Leu Glu Asp Asp Pro Pro Val Ser
 475                 480                 485                 490

 tta ttc tgc tgt tgt aaa aag ta gctatcaggt ttatctgtac tttagaggaa     1845
 Leu Phe Cys Cys Cys Lys Lys 
                 495

 aatataatgt gtagctgagt tggaacactg tggatattct gagatcagat gtagtatgtt   1905

 tgaagactgt tattttgagc taattgagac ctataattca ccaataactg tttatatttt   1965

 taaaagcaat atttaatgtc tttgcaactt tatgctggga ttgtttttaa aaaaacttta   2025

 atgaggaaag ctattggatt attattattt cttgtttatt ttgccatggc tttagaatgt   2085

 attctgtatg cctctctttt gctctgatac tgttgctcct gctattctga ttgtgcagac   2145

 tgtataatta gtggaaaaca atccttggtc tgactgtgac tgtggacaac cagtaaacct   2205

 ggcttggacc actctcagga gtccaccttg agagagtggg tgtagttaca tttatacagt   2265

 aacattgcat gtgaaatctc tcttgagagg aagataagag tgcacagaat aagac        2320




      <210> 215
      <211> 940
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4)..(552)

      <400> 215
 ggg  atg gcg acg cct cgg ccc tgc gcg gac ggg ccc tgc tgc tcg cat      48
      Met Ala Thr Pro Arg Pro Cys Ala Asp Gly Pro Cys Cys Ser His
        1               5                  10                  15

 ccc agc gcg gtg ctc ggc gta cag cag acg ctg gag gag atg gac ttc       96
 Pro Ser Ala Val Leu Gly Val Gln Gln Thr Leu Glu Glu Met Asp Phe
                  20                  25                  30

 gag agg gga atc tgg tcg gca gcc ctg aat gga gac ctg ggc cga gtg      144
 Glu Arg Gly Ile Trp Ser Ala Ala Leu Asn Gly Asp Leu Gly Arg Val
              35                  40                  45

 aag cat tta atc cag aag gcc gag gac cca agt cag ccc gac tcg gcc      192
 Lys His Leu Ile Gln Lys Ala Glu Asp Pro Ser Gln Pro Asp Ser Ala
          50                  55                  60

 ggc tac act gcg ctg cac tat gcc agc cgc aat ggg cac tac gct gtg      240
 Gly Tyr Thr Ala Leu His Tyr Ala Ser Arg Asn Gly His Tyr Ala Val
      65                  70                  75

 tgc cag ttc ctg ctg gaa agc gga gct aag tgt gat gcc cag acc cac      288
 Cys Gln Phe Leu Leu Glu Ser Gly Ala Lys Cys Asp Ala Gln Thr His
  80                  85                  90                  95

 ggg ggt gcc act gct ctg cac cga gcc agc tac tgc ggg cac act gaa      336
 Gly Gly Ala Thr Ala Leu His Arg Ala Ser Tyr Cys Gly His Thr Glu
                 100                 105                 110

 atc gcg cgg ctc ctg cta tca cat ggg tcc aac ccc agg gtg gtg gat      384
 Ile Ala Arg Leu Leu Leu Ser His Gly Ser Asn Pro Arg Val Val Asp
             115                 120                 125

 gac gac ggc atg acc agt ctg cat aag gct gct gag agg ggt cac ggg      432
 Asp Asp Gly Met Thr Ser Leu His Lys Ala Ala Glu Arg Gly His Gly
         130                 135                 140

 gac atc tgc tcc ctc ctc ctg caa cac agc cca gcc ctg aag gcc atc      480
 Asp Ile Cys Ser Leu Leu Leu Gln His Ser Pro Ala Leu Lys Ala Ile
     145                 150                 155

 cgg gac cga aag gca cgg cta gca tgt gac ctg ctg cct tgc aac agt      528
 Arg Asp Arg Lys Ala Arg Leu Ala Cys Asp Leu Leu Pro Cys Asn Ser
 160                 165                 170                 175

 gac ctg cgg gac ctg cta tcc agc tgagccgcca ccctatctcc agctgccttg     582
 Asp Leu Arg Asp Leu Leu Ser Ser 
                 180

 caacagtgac ctgcgggacc tgctatccag ctgagccgcc accctatctc cagctgcctt    642

 taaagggtac acagaccagt tctccaagcc cctgccttgg tcagcatcca tgctgctggg    702

 cagggaactg aggccagacc acccaggaag agccccagtc tggtcactgt ggaagcgagg    762

 gagtagattt ggtgtggcta aaagtgttta agactggaca gatgatcata ttctaaatta    822

 gttcatatga gacatctatt tatttggaaa aaaataaagt tatatcctta cctcatccca    882

 cacccaaaga taaattgcaa gattaaagat ctaaatataa aaacacaaaa aaaaaaaa      940




      <210> 216
      <211> 736
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4)..(348)

      <400> 216
 ggg  atg gcg acg cct cgg ccc tgc gcg gac ggg ccc tgc tgc tcg cat      48
      Met Ala Thr Pro Arg Pro Cys Ala Asp Gly Pro Cys Cys Ser His
        1               5                  10                  15

 ccc agc gcg gtg ctc ggc gta cag cag acg ctg gag gag atg gac ttc       96
 Pro Ser Ala Val Leu Gly Val Gln Gln Thr Leu Glu Glu Met Asp Phe
                  20                  25                  30

 gag agg gga atc tgg tcg gca gcc ctg aat gga gac ctg ggc cga gtg      144
 Glu Arg Gly Ile Trp Ser Ala Ala Leu Asn Gly Asp Leu Gly Arg Val
              35                  40                  45

 aag cat tta atc cag aag gcc gag gac cca agt cag ccc gac tcg gcc      192
 Lys His Leu Ile Gln Lys Ala Glu Asp Pro Ser Gln Pro Asp Ser Ala
          50                  55                  60

 ggc tac act gcg ctg gct gct gag agg ggt cac ggg gac atc tgc tcc      240
 Gly Tyr Thr Ala Leu Ala Ala Glu Arg Gly His Gly Asp Ile Cys Ser
      65                  70                  75

 ctc ctc ctg caa cac agc cca gcc ctg aag gcc atc cgg gac cga aag      288
 Leu Leu Leu Gln His Ser Pro Ala Leu Lys Ala Ile Arg Asp Arg Lys
  80                  85                  90                  95

 gca cgg cta gca tgt gac ctg ctg cct tgc aac agt gac ctg cgg gac      336
 Ala Arg Leu Ala Cys Asp Leu Leu Pro Cys Asn Ser Asp Leu Arg Asp
                 100                 105                 110

 ctg cta tcc agc tga gccgccaccc tatctccagc tgccttgcaa cagtgacctg      391
 Leu Leu Ser Ser 
             115

 cgggacctgc tatccagctg agccgccacc ctatctccag ctgcctttaa agggtacaca    451

 gaccagttct ccaagcccct gccttggtca gcatccatgc tgctgggcag ggaactgagg    511

 ccagaccacc caggaagagc cccagtctgg tcactgtgga agcgagggag tagatttggt    571

 gtggctaaaa gtgtttaaga ctggacagat gatcatattc taaattagtt catatgagac    631

 atctatttat ttggaaaaaa ataaagttat atccttacct catcccacac ccaaagataa    691

 attgcaagat taaagatcta aatataaaaa cacaaaaaaa aaaaa                    736


      <210> 217
      <211> 271
      <212> PRT
      <213> Homo sapiens


      <400> 217
 Met Thr Ala Trp Ile Leu Leu Pro Val Ser Leu Ser Ala Phe Ser Ile
   1               5                  10                  15    
 Thr Gly Ile Trp Thr Val Tyr Ala Met Ala Val Met Asn His His Val
              20                  25                  30        
 Cys Pro Val Glu Asn Trp Ser Tyr Asn Glu Ser Cys Pro Pro Asp Pro
          35                  40                  45            
 Ala Glu Gln Gly Gly Pro Lys Thr Cys Cys Thr Leu Asp Asp Val Pro
      50                  55                  60                
 Leu Ile Ser Lys Cys Gly Ser Tyr Pro Pro Glu Ser Cys Leu Phe Ser
  65                  70                  75                  80
 Leu Ile Gly Asn Met Gly Ala Phe Met Val Ala Leu Ile Cys Leu Leu
                  85                  90                  95    
 Arg Tyr Gly Gln Leu Leu Glu Gln Ser Arg His Ser Trp Val Asn Thr
             100                 105                 110        
 Thr Ala Leu Ile Thr Gly Cys Thr Asn Ala Ala Gly Leu Leu Val Val
         115                 120                 125            
 Gly Asn Phe Gln Val Asp His Ala Arg Ser Leu His Tyr Val Gly Ala
     130                 135                 140                
 Gly Val Ala Phe Pro Ala Gly Leu Leu Phe Val Cys Leu His Cys Ala
 145                 150                 155                 160
 Leu Ser Tyr Gln Gly Ala Thr Ala Pro Leu Asp Leu Ala Val Ala Tyr
                 165                 170                 175    
 Leu Arg Ser Val Leu Ala Val Ile Ala Phe Ile Thr Leu Val Leu Ser
             180                 185                 190        
 Gly Val Phe Phe Val His Glu Ser Ser Gln Leu Gln His Gly Ala Ala
         195                 200                 205            
 Leu Cys Glu Trp Val Cys Val Ile Asp Ile Leu Ile Phe Tyr Gly Thr
     210                 215                 220                
 Phe Ser Tyr Glu Phe Gly Ala Val Ser Ser Asp Thr Leu Val Ala Ala
 225                 230                 235                 240
 Leu Gln Pro Thr Pro Gly Arg Ala Cys Lys Ser Ser Gly Ser Ser Ser
                 245                 250                 255    
 Thr Ser Thr His Leu Asn Cys Ala Pro Glu Ser Ile Ala Met Ile
             260                 265                 270    



      <210> 218
      <211> 237
      <212> PRT
      <213> Homo sapiens


      <400> 218
 Met Leu Gly Gly Ser Leu Gly Ser Arg Leu Leu Arg Gly Val Gly Gly
   1               5                  10                  15    
 Ser His Gly Arg Phe Gly Ala Arg Gly Val Arg Glu Gly Gly Ala Ala
              20                  25                  30        
 Met Ala Ala Gly Glu Ser Met Ala Gln Arg Met Val Trp Val Asp Leu
          35                  40                  45            
 Glu Met Thr Gly Leu Asp Ile Glu Lys Asp Gln Ile Ile Glu Met Ala
      50                  55                  60                
 Cys Leu Ile Thr Asp Ser Asp Leu Asn Ile Leu Ala Glu Gly Pro Asn
  65                  70                  75                  80
 Leu Ile Ile Lys Gln Pro Asp Glu Leu Leu Asp Ser Met Ser Asp Trp
                  85                  90                  95    
 Cys Lys Glu His His Gly Lys Ser Gly Leu Thr Lys Ala Val Lys Glu
             100                 105                 110        
 Ser Thr Ile Thr Leu Gln Gln Ala Glu Tyr Glu Phe Leu Ser Phe Val
         115                 120                 125            
 Arg Gln Gln Thr Pro Pro Gly Leu Cys Pro Leu Ala Gly Asn Ser Val
     130                 135                 140                
 His Glu Asp Lys Lys Phe Leu Asp Lys Tyr Met Pro Gln Phe Met Lys
 145                 150                 155                 160
 His Leu His Tyr Arg Ile Ile Asp Val Ser Thr Val Lys Glu Leu Cys
                 165                 170                 175    
 Arg Arg Trp Tyr Pro Glu Glu Tyr Glu Phe Ala Pro Lys Lys Ala Ala
             180                 185                 190        
 Ser His Arg Ala Leu Asp Asp Ile Ser Glu Ser Ile Lys Glu Leu Gln
         195                 200                 205            
 Phe Tyr Arg Asn Asn Ile Phe Lys Lys Lys Ile Asp Glu Lys Lys Arg
     210                 215                 220                
 Lys Ile Ile Glu Asn Gly Glu Asn Glu Lys Thr Val Ser
 225                 230                 235        



      <210> 219
      <211> 334
      <212> PRT
      <213> Homo sapiens


      <400> 219
 Met Ala Thr Leu Lys Glu Lys Leu Ile Ala Pro Val Ala Glu Glu Glu
   1               5                  10                  15    
 Ala Thr Val Pro Asn Asn Lys Ile Thr Val Val Gly Val Gly Gln Val
              20                  25                  30        
 Gly Met Ala Cys Ala Ile Ser Ile Leu Gly Lys Ser Leu Ala Asp Glu
          35                  40                  45            
 Leu Ala Leu Val Asp Val Leu Glu Asp Lys Leu Lys Gly Glu Met Met
      50                  55                  60                
 Asp Leu Gln His Gly Ser Leu Phe Leu Gln Thr Pro Lys Ile Val Ala
  65                  70                  75                  80
 Asp Lys Asp Tyr Ser Val Thr Ala Asn Ser Lys Ile Val Val Val Thr
                  85                  90                  95    
 Ala Gly Val Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln
             100                 105                 110        
 Arg Asn Val Asn Val Phe Lys Phe Ile Ile Pro Gln Ile Val Lys Tyr
         115                 120                 125            
 Ser Pro Asp Cys Ile Ile Ile Val Val Ser Asn Pro Val Asp Ile Leu
     130                 135                 140                
 Thr Tyr Val Thr Trp Lys Leu Ser Gly Leu Pro Lys His Arg Val Ile
 145                 150                 155                 160
 Gly Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Ala
                 165                 170                 175    
 Glu Lys Leu Gly Ile His Pro Ser Ser Cys His Gly Trp Ile Leu Gly
             180                 185                 190        
 Glu His Gly Asp Ser Ser Val Ala Val Trp Ser Gly Val Asn Val Ala
         195                 200                 205            
 Gly Val Ser Leu Gln Glu Leu Asn Pro Glu Met Gly Thr Asp Asn Asp
     210                 215                 220                
 Ser Glu Asn Trp Lys Glu Val His Lys Met Val Val Glu Ser Ala Tyr
 225                 230                 235                 240
 Glu Val Ile Lys Leu Lys Gly Tyr Thr Asn Trp Ala Ile Gly Leu Ser
                 245                 250                 255    
 Val Ala Asp Leu Ile Glu Ser Met Leu Lys Asn Leu Ser Arg Ile His
             260                 265                 270        
 Pro Val Ser Thr Met Val Lys Gly Met Tyr Gly Ile Glu Asn Glu Val
         275                 280                 285            
 Phe Leu Ser Leu Pro Cys Ile Leu Asn Ala Arg Gly Leu Thr Ser Val
     290                 295                 300                
 Ile Asn Gln Lys Leu Lys Asp Asp Glu Val Ala Gln Leu Lys Lys Ser
 305                 310                 315                 320
 Ala Asp Thr Leu Trp Asp Ile Gln Lys Asp Leu Lys Asp Leu
                 325                 330                



      <210> 220
      <211> 426
      <212> PRT
      <213> Homo sapiens


      <400> 220
 Met Ser Glu Ala Asp Gly Leu Arg Gln Arg Arg Pro Leu Arg Pro Gln
   1               5                  10                  15    
 Val Val Thr Asp Asp Asp Gly Gln Ala Pro Glu Ala Lys Asp Gly Ser
              20                  25                  30        
 Ser Phe Ser Gly Arg Val Phe Arg Val Thr Phe Leu Met Leu Ala Val
          35                  40                  45            
 Ser Leu Thr Val Pro Leu Leu Gly Ala Met Met Leu Leu Glu Ser Pro
      50                  55                  60                
 Ile Asp Pro Gln Pro Leu Arg Gln Ile Ser Gly Ile Ala Leu Phe Cys
  65                  70                  75                  80
 Ser Phe Lys Glu Pro Pro Leu Leu Leu Gly Val Leu His Pro Asn Thr
                  85                  90                  95    
 Lys Leu Arg Gln Ala Glu Arg Leu Phe Glu Asn Gln Leu Val Gly Pro
             100                 105                 110        
 Glu Ser Ile Ala His Ile Gly Asp Val Met Phe Thr Gly Thr Ala Asp
         115                 120                 125            
 Gly Arg Val Val Lys Leu Glu Asn Gly Glu Ile Glu Thr Ile Ala Arg
     130                 135                 140                
 Phe Gly Ser Gly Pro Cys Lys Thr Arg Asp Asp Glu Pro Val Cys Gly
 145                 150                 155                 160
 Arg Pro Leu Gly Ile Arg Ala Gly Pro Asn Gly Thr Leu Phe Val Ala
                 165                 170                 175    
 Asp Ala Tyr Lys Gly Leu Phe Glu Val Asn Pro Trp Lys Arg Glu Val
             180                 185                 190        
 Lys Leu Leu Leu Ser Ser Glu Thr Pro Ile Glu Gly Lys Asn Met Ser
         195                 200                 205            
 Phe Val Asn Asp Leu Thr Val Thr Gln Asp Gly Arg Lys Ile Tyr Phe
     210                 215                 220                
 Thr Asp Ser Ser Ser Lys Trp Gln Arg Arg Asp Tyr Leu Leu Leu Val
 225                 230                 235                 240
 Met Glu Gly Thr Asp Asp Gly Arg Leu Leu Glu Tyr Asp Thr Val Thr
                 245                 250                 255    
 Arg Glu Val Lys Val Leu Leu Asp Gln Leu Arg Phe Pro Asn Gly Val
             260                 265                 270        
 Gln Leu Ser Pro Ala Glu Asp Phe Val Leu Val Ala Glu Thr Thr Met
         275                 280                 285            
 Ala Arg Ile Arg Arg Val Tyr Val Ser Gly Leu Met Lys Gly Gly Ala
     290                 295                 300                
 Asp Leu Phe Val Glu Asn Met Pro Gly Phe Pro Asp Asn Ile Arg Pro
 305                 310                 315                 320
 Ser Ser Ser Gly Gly Tyr Trp Val Gly Met Ser Thr Ile Arg Pro Asn
                 325                 330                 335    
 Pro Gly Phe Ser Met Leu Asp Phe Leu Ser Glu Arg Pro Trp Ile Lys
             340                 345                 350        
 Arg Met Ile Phe Lys Leu Phe Ser Gln Glu Thr Val Met Lys Phe Val
         355                 360                 365            
 Pro Arg Tyr Ser Leu Val Leu Glu Leu Ser Asp Ser Gly Ala Phe Arg
     370                 375                 380                
 Arg Ser Leu His Asp Pro Asp Gly Leu Val Ala Thr Tyr Ile Ser Glu
 385                 390                 395                 400
 Val His Glu His Asp Gly His Leu Tyr Leu Gly Ser Phe Arg Ser Pro
                 405                 410                 415    
 Phe Leu Cys Arg Leu Ser Leu Gln Ala Val
             420                 425    



      <210> 221
      <211> 309
      <212> PRT
      <213> Homo sapiens


      <400> 221
 Met Ser Trp Cys Asn Glu Leu Arg Leu Pro Ala Leu Lys Gln His Ser
   1               5                  10                  15    
 Ile Gly Arg Gly Leu Glu Ser His Ile Thr Met Cys Ile Pro Pro Ser
              20                  25                  30        
 Tyr Ala Asp Leu Gly Lys Ala Ala Arg Asp Ile Phe Asn Lys Gly Phe
          35                  40                  45            
 Gly Phe Gly Leu Val Lys Leu Asp Val Lys Thr Lys Ser Cys Ser Gly
      50                  55                  60                
 Val Glu Phe Ser Thr Ser Gly Ser Ser Asn Thr Asp Thr Gly Lys Val
  65                  70                  75                  80
 Thr Gly Thr Leu Glu Thr Lys Tyr Lys Trp Cys Glu Tyr Gly Leu Thr
                  85                  90                  95    
 Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr Leu Gly Thr Glu Ile Ala
             100                 105                 110        
 Ile Glu Asp Gln Ile Cys Gln Gly Leu Lys Leu Thr Phe Asp Thr Thr
         115                 120                 125            
 Phe Ser Pro Asn Thr Gly Lys Lys Ser Gly Lys Ile Lys Ser Ser Tyr
     130                 135                 140                
 Lys Arg Glu Cys Ile Asn Leu Gly Cys Asp Val Asp Phe Asp Phe Ala
 145                 150                 155                 160
 Gly Pro Ala Ile His Gly Ser Ala Val Phe Gly Tyr Glu Gly Trp Leu
                 165                 170                 175    
 Ala Gly Tyr Gln Met Thr Phe Asp Ser Ala Lys Ser Lys Leu Thr Arg
             180                 185                 190        
 Asn Asn Phe Ala Val Gly Tyr Arg Thr Gly Asp Phe Gln Leu His Thr
         195                 200                 205            
 Asn Val Asn Asp Gly Thr Glu Phe Gly Gly Ser Ile Tyr Gln Lys Val
     210                 215                 220                
 Cys Glu Asp Leu Asp Thr Ser Val Asn Leu Ala Trp Thr Ser Gly Thr
 225                 230                 235                 240
 Asn Cys Thr Arg Phe Gly Ile Ala Ala Lys Tyr Gln Leu Asp Pro Thr
                 245                 250                 255    
 Ala Ser Ile Ser Ala Lys Val Asn Asn Ser Ser Leu Ile Gly Val Gly
             260                 265                 270        
 Tyr Thr Gln Thr Leu Arg Pro Gly Val Lys Leu Thr Leu Ser Ala Leu
         275                 280                 285            
 Val Asp Gly Lys Ser Ile Asn Ala Gly Gly His Lys Val Gly Leu Ala
     290                 295                 300                
 Leu Glu Leu Glu Ala
 305                



      <210> 222
      <211> 136
      <212> PRT
      <213> Homo sapiens


      <400> 222
 Met Ala Ser Val Arg Ile Arg Glu Ala Lys Glu Gly Asp Cys Gly Asp
   1               5                  10                  15    
 Ile Leu Arg Leu Ile Arg Glu Leu Ala Glu Phe Glu Lys Leu Ser Asp
              20                  25                  30        
 Gln Val Lys Ile Ser Glu Glu Ala Leu Arg Ala Asp Gly Phe Gly Asp
          35                  40                  45            
 Asn Pro Phe Tyr His Cys Leu Val Ala Glu Ile Leu Pro Ala Pro Gly
      50                  55                  60                
 Lys Leu Leu Gly Gln Gly Ile Gly Ser Lys Ile Ile Lys Lys Val Ala
  65                  70                  75                  80
 Glu Val Ala Leu Asp Lys Gly Cys Ser Gln Phe Arg Leu Ala Val Leu
                  85                  90                  95    
 Asp Trp Asn Gln Arg Ala Met Asp Leu Tyr Lys Ala Leu Gly Ala Gln
             100                 105                 110        
 Asp Leu Thr Glu Ala Glu Gly Trp His Phe Phe Cys Phe Gln Gly Glu
         115                 120                 125            
 Ala Thr Arg Lys Leu Ala Gly Lys
     130                 135    



      <210> 223
      <211> 102
      <212> PRT
      <213> Homo sapiens


      <400> 223
 Met Ser Ala Arg Val Arg Ser Arg Ser Arg Gly Arg Gly Asp Gly Gln
   1               5                  10                  15    
 Glu Ala Pro Asp Val Val Ala Phe Val Ala Pro Gly Glu Ser Gln Gln
              20                  25                  30        
 Glu Glu Pro Pro Thr Asp Asn Gln Asp Ile Glu Pro Gly Gln Glu Arg
          35                  40                  45            
 Glu Gly Thr Pro Pro Ile Glu Glu Arg Lys Val Glu Gly Asp Cys Gln
      50                  55                  60                
 Glu Met Asp Leu Glu Lys Thr Arg Ser Glu Arg Gly Asp Gly Ser Asp
  65                  70                  75                  80
 Val Lys Glu Lys Thr Pro Pro Asn Pro Lys His Ala Lys Thr Lys Glu
                  85                  90                  95    
 Ala Gly Asp Gly Gln Pro
             100        



      <210> 224
      <211> 1162
      <212> PRT
      <213> Homo sapiens


      <400> 224
 Met Asn Gly His His Gln Gln Asn Gly Val Glu Asn Met Met Leu Phe
   1               5                  10                  15    
 Glu Val Val Lys Met Gly Lys Ser Ala Met Gln Ser Val Val Asp Asp
              20                  25                  30        
 Trp Ile Glu Ser Tyr Lys His Asp Arg Asp Ile Ala Leu Leu Asp Leu
          35                  40                  45            
 Ile Asn Phe Phe Ile Gln Cys Ser Gly Cys Lys Gly Val Val Thr Ala
      50                  55                  60                
 Glu Met Phe Arg His Met Gln Asn Ser Glu Ile Ile Arg Lys Met Thr
  65                  70                  75                  80
 Glu Glu Phe Asp Glu Asp Ser Gly Asp Tyr Pro Leu Thr Met Ala Gly
                  85                  90                  95    
 Pro Gln Trp Lys Lys Phe Lys Ser Ser Phe Cys Glu Phe Ile Gly Val
             100                 105                 110        
 Leu Val Arg Gln Cys Gln Tyr Ser Ile Ile Tyr Asp Glu Tyr Met Met
         115                 120                 125            
 Asp Thr Val Ile Ser Leu Leu Thr Gly Leu Ser Asp Ser Gln Val Arg
     130                 135                 140                
 Ala Phe Arg His Thr Ser Thr Leu Ala Ala Met Lys Leu Met Thr Ala
 145                 150                 155                 160
 Leu Val Asn Val Ala Leu Asn Leu Ser Ile Asn Met Asp Asn Thr Gln
                 165                 170                 175    
 Arg Gln Tyr Glu Ala Glu Arg Asn Lys Met Ile Gly Lys Arg Ala Asn
             180                 185                 190        
 Glu Arg Leu Glu Leu Leu Leu Gln Lys Arg Lys Glu Leu Gln Glu Asn
         195                 200                 205            
 Gln Asp Glu Ile Glu Asn Met Met Asn Ala Ile Phe Lys Gly Val Phe
     210                 215                 220                
 Val His Arg Tyr Arg Asp Ala Ile Arg Glu Ile Arg Ala Ile Cys Ile
 225                 230                 235                 240
 Glu Glu Ile Gly Ile Trp Met Lys Met Tyr Ser Asp Ala Phe Leu Asn
                 245                 250                 255    
 Asp Ser Tyr Leu Lys Tyr Val Gly Trp Thr Met His Asp Lys Gln Gly
             260                 265                 270        
 Glu Val Arg Leu Lys Cys Leu Thr Ala Leu Gln Gly Leu Tyr Tyr Asn
         275                 280                 285            
 Lys Glu Leu Asn Ser Lys Leu Glu Leu Phe Thr Ser Arg Phe Lys Asp
     290                 295                 300                
 Arg Ile Val Ser Met Thr Leu Asp Lys Glu Tyr Asp Val Ala Val Gln
 305                 310                 315                 320
 Ala Ile Lys Leu Leu Thr Leu Val Leu Gln Ser Ser Glu Glu Val Leu
                 325                 330                 335    
 Thr Ala Glu Asp Cys Glu Asn Val Tyr His Leu Val Tyr Ser Ala His
             340                 345                 350        
 Arg Pro Val Ala Val Ala Ala Gly Glu Phe Leu Tyr Lys Lys Leu Phe
         355                 360                 365            
 Ser Arg Arg Asp Pro Glu Glu Asp Gly Met Met Lys Arg Arg Gly Arg
     370                 375                 380                
 Gln Gly Pro Asn Ala Asn Leu Val Lys Thr Leu Val Phe Phe Phe Leu
 385                 390                 395                 400
 Glu Ser Glu Leu His Glu His Ala Ala Tyr Leu Val Asp Ser Met Trp
                 405                 410                 415    
 Asp Cys Ala Thr Glu Leu Leu Lys Asp Trp Glu Cys Met Asn Ser Leu
             420                 425                 430        
 Leu Leu Glu Glu Pro Leu Ser Gly Glu Glu Ala Leu Thr Asp Arg Gln
         435                 440                 445            
 Glu Ser Ala Leu Ile Glu Ile Met Leu Cys Thr Ile Arg Gln Ala Ala
     450                 455                 460                
 Glu Cys His Pro Pro Val Gly Arg Gly Thr Gly Lys Arg Val Leu Thr
 465                 470                 475                 480
 Ala Lys Glu Lys Lys Thr Gln Leu Asp Asp Arg Thr Lys Ile Thr Glu
                 485                 490                 495    
 Leu Phe Ala Val Ala Leu Pro Gln Leu Leu Ala Lys Tyr Ser Val Asp
             500                 505                 510        
 Ala Glu Lys Val Thr Asn Leu Leu Gln Leu Pro Gln Tyr Phe Asp Leu
         515                 520                 525            
 Glu Ile Tyr Thr Thr Gly Arg Leu Glu Lys His Leu Asp Ala Leu Leu
     530                 535                 540                
 Arg Gln Ile Arg Asn Ile Val Glu Lys His Thr Asp Thr Asp Val Leu
 545                 550                 555                 560
 Glu Ala Cys Ser Lys Thr Tyr His Ala Leu Cys Asn Glu Glu Phe Thr
                 565                 570                 575    
 Ile Phe Asn Arg Val Asp Ile Ser Arg Ser Gln Leu Ile Asp Glu Leu
             580                 585                 590        
 Ala Asp Lys Phe Asn Arg Leu Leu Glu Asp Phe Leu Gln Glu Gly Glu
         595                 600                 605            
 Glu Pro Asp Glu Asp Asp Ala Tyr Gln Val Leu Ser Thr Leu Lys Arg
     610                 615                 620                
 Ile Thr Ala Phe His Asn Ala His Asp Leu Ser Lys Arg Asp Leu Phe
 625                 630                 635                 640
 Ala Cys Asn Tyr Lys Leu Leu Lys Thr Gly Ile Glu Asn Gly Asp Met
                 645                 650                 655    
 Pro Glu Gln Ile Val Ile His Ala Leu Gln Cys Thr His Tyr Val Ile
             660                 665                 670        
 Leu Trp Gln Leu Ala Lys Ile Thr Glu Ser Ser Ser Thr Lys Glu Asp
         675                 680                 685            
 Leu Leu Arg Leu Lys Lys Gln Met Arg Val Phe Cys Gln Ile Cys Gln
     690                 695                 700                
 His Tyr Leu Thr Asn Val Asn Thr Thr Val Lys Glu Gln Ala Phe Thr
 705                 710                 715                 720
 Ile Leu Cys Asp Ile Leu Met Ile Phe Ser His Gln Ile Met Ser Gly
                 725                 730                 735    
 Gly Arg Asp Met Leu Glu Pro Leu Val Tyr Thr Pro Asp Ser Ser Leu
             740                 745                 750        
 Gln Ser Glu Leu Leu Ser Phe Ile Leu Asp His Val Phe Ile Glu Gln
         755                 760                 765            
 Asp Asp Asp Asn Asn Ser Ala Asp Gly Gln Gln Glu Asp Glu Ala Ser
     770                 775                 780                
 Lys Ile Glu Ala Leu His Lys Arg Arg Asn Leu Leu Ala Ala Phe Cys
 785                 790                 795                 800
 Lys Leu Ile Val Tyr Thr Val Val Glu Met Asn Thr Ala Ala Asp Ile
                 805                 810                 815    
 Phe Lys Gln Tyr Met Lys Tyr Tyr Asn Asp Tyr Gly Asp Ile Ile Lys
             820                 825                 830        
 Glu Thr Met Ser Lys Thr Arg Gln Ile Asp Lys Ile Gln Cys Ala Lys
         835                 840                 845            
 Thr Leu Ile Leu Ser Leu Gln Gln Leu Phe Asn Glu Met Ile Gln Glu
     850                 855                 860                
 Asn Gly Tyr Asn Phe Asp Arg Ser Ser Ser Thr Phe Ser Gly Ile Lys
 865                 870                 875                 880
 Glu Leu Ala Arg Arg Phe Ala Leu Thr Phe Gly Leu Asp Gln Leu Lys
                 885                 890                 895    
 Thr Arg Glu Ala Ile Ala Met Leu His Lys Asp Gly Ile Glu Phe Ala
             900                 905                 910        
 Phe Lys Glu Pro Asn Pro Gln Gly Glu Ser His Pro Pro Leu Asn Leu
         915                 920                 925            
 Ala Phe Leu Asp Ile Leu Ser Glu Phe Ser Ser Lys Leu Leu Arg Gln
     930                 935                 940                
 Asp Lys Arg Thr Val Tyr Val Tyr Leu Glu Lys Phe Met Thr Phe Gln
 945                 950                 955                 960
 Met Ser Leu Arg Arg Glu Asp Val Trp Leu Pro Leu Met Ser Tyr Arg
                 965                 970                 975    
 Asn Ser Leu Leu Ala Gly Gly Asp Asp Asp Thr Met Ser Val Ile Ser
             980                 985                 990        
 Gly Ile Ser Ser Arg Gly Ser Thr Val Arg Ser Lys Lys Ser Lys Pro
         995                1000                1005            
 Ser Thr Gly Lys Arg Lys Val Val Glu Gly Met Gln Leu Ser Leu Thr
    1010                1015                1020                
 Glu Glu Ser Ser Ser Ser Asp Ser Met Trp Leu Ser Arg Glu Gln Thr
1025                1030                1035                1040
 Leu His Thr Pro Val Met Met Gln Thr Pro Gln Leu Thr Ser Thr Ile
                1045                1050                1055    
 Met Arg Glu Pro Lys Arg Leu Arg Pro Glu Asp Ser Phe Met Ser Val
            1060                1065                1070        
 Tyr Pro Met Gln Thr Glu His His Gln Thr Pro Leu Asp Tyr Asn Arg
        1075                1080                1085            
 Arg Gly Thr Ser Leu Met Glu Asp Asp Glu Glu Pro Ile Val Glu Asp
    1090                1095                1100                
 Val Met Met Ser Ser Glu Gly Arg Ile Glu Asp Leu Asn Glu Gly Met
1105                1110                1115                1120
 Asp Phe Asp Thr Met Asp Ile Asp Leu Pro Pro Ser Lys Asn Arg Arg
                1125                1130                1135    
 Glu Arg Thr Glu Leu Lys Pro Asp Phe Phe Asp Pro Ala Ser Ile Met
            1140                1145                1150        
 Asp Glu Ser Val Leu Gly Val Ser Met Phe
        1155                1160        



      <210> 225
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 225
 Met Asn His Thr Val Gln Thr Phe Phe Ser Pro Val Asn Ser Gly Gln
   1               5                  10                  15    
 Pro Pro Asn Tyr Glu Met Leu Lys Glu Glu His Glu Val Ala Val Leu
              20                  25                  30        
 Gly Ala Pro His Asn Pro Ala Pro Pro Thr Ser Thr Val Ile His Ile
          35                  40                  45            
 Arg Ser Glu Thr Ser Val Pro Asp His Val Val Trp Ser Leu Phe Asn
      50                  55                  60                
 Thr Leu Phe Met Asn Pro Cys Cys Leu Gly Phe Ile Ala Phe Ala Tyr
  65                  70                  75                  80
 Ser Val Lys Ser Arg Asp Arg Lys Met Val Gly Asp Val Thr Gly Ala
                  85                  90                  95    
 Gln Ala Tyr Ala Ser Thr Ala Lys Cys Leu Asn Ile Trp Ala Leu Ile
             100                 105                 110        
 Leu Gly Ile Leu Met Thr Ile Leu Leu Ile Val Ile Pro Val Leu Ile
         115                 120                 125            
 Phe Gln Ala Tyr Gly
     130            



      <210> 226
      <211> 377
      <212> PRT
      <213> Homo sapiens


      <400> 226
 Met Ala Glu Glu Val Val Val Val Ala Lys Phe Asp Tyr Val Ala Gln
   1               5                  10                  15    
 Gln Glu Gln Glu Leu Asp Ile Lys Lys Asn Glu Arg Leu Trp Leu Leu
              20                  25                  30        
 Asp Asp Ser Lys Ser Trp Trp Arg Val Arg Asn Ser Met Asn Lys Thr
          35                  40                  45            
 Gly Phe Val Pro Ser Asn Tyr Val Glu Arg Lys Asn Ser Ala Arg Lys
      50                  55                  60                
 Ala Ser Ile Val Lys Asn Leu Lys Asp Thr Leu Gly Ile Gly Lys Val
  65                  70                  75                  80
 Lys Arg Lys Pro Ser Val Pro Asp Ser Ala Ser Pro Ala Asp Asp Ser
                  85                  90                  95    
 Phe Val Asp Pro Gly Glu Arg Leu Tyr Asp Leu Asn Met Pro Ala Tyr
             100                 105                 110        
 Val Lys Phe Asn Tyr Met Ala Glu Arg Glu Asp Glu Leu Ser Leu Ile
         115                 120                 125            
 Lys Gly Thr Lys Val Ile Val Met Glu Lys Cys Ser Asp Gly Trp Trp
     130                 135                 140                
 Arg Gly Ser Tyr Asn Gly Gln Val Gly Trp Phe Pro Ser Asn Tyr Val
 145                 150                 155                 160
 Thr Glu Glu Gly Asp Ser Pro Leu Gly Asp His Val Gly Ser Leu Ser
                 165                 170                 175    
 Glu Lys Leu Ala Ala Val Val Asn Asn Leu Asn Thr Gly Gln Val Leu
             180                 185                 190        
 His Val Val Gln Ala Leu Tyr Pro Phe Ser Ser Ser Asn Asp Glu Glu
         195                 200                 205            
 Leu Asn Phe Glu Lys Gly Asp Val Met Asp Val Ile Glu Lys Pro Glu
     210                 215                 220                
 Asn Asp Pro Glu Trp Trp Lys Cys Arg Lys Ile Asn Gly Met Val Gly
 225                 230                 235                 240
 Leu Val Pro Lys Asn Tyr Val Thr Val Met Gln Asn Asn Pro Leu Thr
                 245                 250                 255    
 Ser Gly Leu Glu Pro Ser Pro Pro Gln Cys Asp Tyr Ile Arg Pro Ser
             260                 265                 270        
 Leu Thr Gly Lys Phe Ala Gly Asn Pro Trp Tyr Tyr Gly Lys Val Thr
         275                 280                 285            
 Arg His Gln Ala Glu Met Ala Leu Asn Glu Arg Gly His Glu Gly Asp
     290                 295                 300                
 Phe Leu Ile Arg Asp Ser Glu Ser Ser Pro Asn Asp Phe Ser Val Ser
 305                 310                 315                 320
 Leu Lys Ala Gln Gly Lys Asn Lys His Phe Lys Val Gln Leu Lys Glu
                 325                 330                 335    
 Thr Val Tyr Cys Ile Gly Gln Arg Lys Phe Ser Thr Met Glu Glu Leu
             340                 345                 350        
 Val Glu His Tyr Lys Lys Ala Pro Ile Phe Thr Ser Glu Gln Gly Glu
         355                 360                 365            
 Lys Leu Tyr Leu Val Lys His Leu Ser
     370                 375        



      <210> 227
      <211> 255
      <212> PRT
      <213> Homo sapiens


      <400> 227
 Met Ala Glu Leu Arg Val Leu Val Ala Val Lys Arg Val Ile Asp Tyr
   1               5                  10                  15    
 Ala Val Lys Ile Arg Val Lys Pro Asp Arg Thr Gly Val Val Thr Asp
              20                  25                  30        
 Gly Val Lys His Ser Met Asn Pro Phe Cys Glu Ile Ala Val Glu Glu
          35                  40                  45            
 Ala Val Arg Leu Lys Glu Lys Lys Leu Val Lys Glu Val Ile Ala Val
      50                  55                  60                
 Ser Cys Gly Pro Ala Gln Cys Gln Glu Thr Ile Arg Thr Ala Leu Ala
  65                  70                  75                  80
 Met Gly Ala Asp Arg Gly Ile His Val Glu Val Pro Pro Ala Glu Ala
                  85                  90                  95    
 Glu Arg Leu Gly Pro Leu Gln Val Ala Arg Val Leu Ala Lys Leu Ala
             100                 105                 110        
 Glu Lys Glu Lys Val Asp Leu Val Leu Leu Gly Lys Gln Ala Ile Asp
         115                 120                 125            
 Asp Asp Cys Asn Gln Thr Gly Gln Met Thr Ala Gly Phe Leu Asp Trp
     130                 135                 140                
 Pro Gln Gly Thr Phe Ala Ser Gln Val Met Leu Glu Gly Asp Lys Leu
 145                 150                 155                 160
 Lys Val Glu Arg Glu Ile Asp Gly Gly Leu Glu Thr Leu Arg Leu Lys
                 165                 170                 175    
 Leu Pro Ala Val Val Thr Ala Asp Leu Arg Leu Asn Glu Pro Arg Tyr
             180                 185                 190        
 Ala Thr Leu Pro Asn Ile Met Lys Ala Lys Lys Lys Lys Ile Glu Val
         195                 200                 205            
 Ile Lys Pro Gly Asp Leu Gly Val Asp Leu Thr Ser Lys Leu Ser Val
     210                 215                 220                
 Ile Ser Val Glu Asp Pro Pro Gln Arg Thr Ala Gly Val Lys Val Glu
 225                 230                 235                 240
 Thr Thr Glu Asp Leu Val Ala Lys Leu Lys Glu Ile Gly Arg Ile
                 245                 250                 255



      <210> 228
      <211> 371
      <212> PRT
      <213> Homo sapiens


      <400> 228
 Met Gly His Lys Val Val Val Phe Asp Ile Ser Val Ile Arg Ala Leu
   1               5                  10                  15    
 Trp Glu Thr Arg Val Lys Lys His Lys Ala Trp Gln Lys Lys Glu Val
              20                  25                  30        
 Glu Arg Leu Glu Lys Ser Ala Leu Glu Lys Ile Lys Glu Glu Trp Asn
          35                  40                  45            
 Phe Val Ala Glu Cys Arg Arg Lys Gly Ile Pro Gln Ala Val Tyr Cys
      50                  55                  60                
 Lys Asn Gly Phe Ile Asp Thr Ser Val Arg Leu Leu Asp Lys Ile Glu
  65                  70                  75                  80
 Arg Asn Thr Leu Thr Arg Gln Ser Ser Leu Pro Lys Asp Arg Gly Lys
                  85                  90                  95    
 Arg Ser Ser Ala Phe Val Phe Glu Leu Ser Gly Glu His Trp Thr Glu
             100                 105                 110        
 Leu Pro Asp Ser Leu Lys Glu Gln Thr His Leu Arg Glu Trp Tyr Ile
         115                 120                 125            
 Ser Asn Thr Leu Ile Gln Ile Ile Pro Thr Tyr Ile Gln Leu Phe Gln
     130                 135                 140                
 Ala Met Arg Ile Leu Asp Leu Pro Lys Asn Gln Ile Ser His Leu Pro
 145                 150                 155                 160
 Ala Glu Ile Gly Cys Leu Lys Asn Leu Lys Glu Leu Asn Val Gly Phe
                 165                 170                 175    
 Asn Tyr Leu Lys Ser Ile Pro Pro Glu Leu Gly Asp Cys Glu Asn Leu
             180                 185                 190        
 Glu Arg Leu Asp Cys Ser Gly Asn Leu Glu Leu Met Glu Leu Pro Phe
         195                 200                 205            
 Glu Leu Ser Asn Leu Lys Gln Val Thr Phe Val Asp Ile Ser Ala Asn
     210                 215                 220                
 Lys Phe Ser Ser Val Pro Ile Cys Val Leu Arg Met Ser Asn Leu Gln
 225                 230                 235                 240
 Trp Leu Asp Ile Ser Ser Asn Asn Leu Thr Asp Leu Pro Gln Asp Ile
                 245                 250                 255    
 Asp Arg Leu Glu Glu Leu Gln Ser Phe Leu Leu Tyr Lys Asn Lys Leu
             260                 265                 270        
 Thr Tyr Leu Pro Tyr Ser Met Leu Asn Leu Lys Lys Leu Thr Leu Leu
         275                 280                 285            
 Val Val Ser Gly Asp His Leu Val Glu Leu Pro Thr Ala Leu Cys Asp
     290                 295                 300                
 Ser Ser Thr Pro Leu Lys Phe Val Ser Leu Met Asp Asn Pro Ile Asp
 305                 310                 315                 320
 Asn Ala Gln Cys Glu Asp Gly Asn Glu Ile Met Glu Ser Glu Arg Asp
                 325                 330                 335    
 Arg Gln His Phe Asp Lys Glu Val Met Lys Ala Tyr Ile Glu Asp Leu
             340                 345                 350        
 Lys Glu Arg Glu Ser Val Pro Ser Tyr Thr Thr Lys Val Ser Phe Ser
         355                 360                 365            
 Leu Gln Leu
     370    



      <210> 229
      <211> 116
      <212> PRT
      <213> Homo sapiens


      <400> 229
 Met Arg Arg Asp Asp Ser Ala His Ala Ser Met Val Asn Val Pro Lys
   1               5                  10                  15    
 Thr Arg Arg Thr Phe Cys Lys Lys Cys Gly Lys His Gln Pro His Lys
              20                  25                  30        
 Val Thr Gln Tyr Lys Lys Gly Lys Asp Ser Leu Tyr Ala Gln Gly Lys
          35                  40                  45            
 Arg Arg Tyr Asp Arg Lys Gln Ser Gly Tyr Gly Gly Gln Thr Lys Pro
      50                  55                  60                
 Ile Phe Arg Lys Lys Ala Lys Thr Thr Lys Lys Ile Val Leu Arg Leu
  65                  70                  75                  80
 Glu Cys Val Glu Pro Asn Cys Arg Ser Lys Arg Met Leu Ala Ile Lys
                  85                  90                  95    
 Arg Cys Lys His Phe Glu Leu Gly Gly Asp Lys Lys Arg Lys Gly Gln
             100                 105                 110        
 Val Ile Gln Phe
         115    



      <210> 230
      <211> 386
      <212> PRT
      <213> Homo sapiens


      <400> 230
 Met Glu Leu Lys Ala Lys Ala Arg Glu Leu Arg Glu Glu Cys Arg Ser
   1               5                  10                  15    
 Leu Arg Ser Arg Cys Asp Gln Leu Glu Glu Arg Val Ser Val Met Glu
              20                  25                  30        
 Asn Glu Met Asn Glu Met Lys Arg Glu Gly Lys Phe Arg Glu Lys Arg
          35                  40                  45            
 Ile Lys Arg Asn Glu Gln Ser Leu Gln Glu Ile Trp Asp Tyr Val Lys
      50                  55                  60                
 Arg Pro Asn Leu His Leu Ile Gly Val Pro Glu Ser Asp Gly Glu Asn
  65                  70                  75                  80
 Gly Thr Lys Leu Glu Asn Thr Leu Gln Asp Ile Ile Gln Glu Asn Phe
                  85                  90                  95    
 Pro Asn Leu Ala Arg Gln Ala Asn Ile Gln Ile Gln Glu Ile Gln Arg
             100                 105                 110        
 Thr Pro Gln Arg Tyr Ser Ser Arg Arg Ala Thr Pro Arg His Ile Ile
         115                 120                 125            
 Val Arg Ile Thr Lys Val Glu Met Lys Glu Lys Met Leu Arg Ala Ala
     130                 135                 140                
 Arg Glu Lys Gly Arg Val Pro His Lys Gly Lys Pro Ile Arg Leu Thr
 145                 150                 155                 160
 Ala Asp Leu Ser Ser Glu Thr Leu Gln Ala Arg Arg Glu Trp Gly Pro
                 165                 170                 175    
 Ile Phe Asn Ile Leu Lys Arg Ile Phe Ser Phe Pro Gln Arg Gly Gly
             180                 185                 190        
 Thr Gly Gly Arg Arg Met Val Lys Leu Thr Ala Glu Leu Ile Glu Gln
         195                 200                 205            
 Ala Ala Gln Tyr Thr Ser Ala Val Arg Asp Arg Glu Leu Asp Leu Arg
     210                 215                 220                
 Gly Tyr Lys Ile Pro Val Ile Glu Asn Leu Gly Ala Thr Leu Asp Gln
 225                 230                 235                 240
 Phe Asp Ala Ile Asp Phe Ser Asp Asn Glu Ile Arg Lys Leu Asp Gly
                 245                 250                 255    
 Phe Pro Leu Leu Arg Arg Leu Lys Thr Leu Leu Val Asn Lys Thr Glu
             260                 265                 270        
 Tyr Ala Ser Thr Gly Phe Pro Glu Ser Glu Thr Lys Glu Arg Gln Glu
         275                 280                 285            
 Ala Glu Lys Met Phe Lys Gly Lys Arg Gly Ala Gln Leu Ala Lys Asp
     290                 295                 300                
 Ile Ala Arg Arg Ser Lys Thr Phe Asn Pro Gly Ala Gly Leu Pro Thr
 305                 310                 315                 320
 Asp Lys Lys Lys Gly Gly Pro Ser Pro Gly Asp Val Glu Ala Ile Lys
                 325                 330                 335    
 Asn Ala Ile Ala Asn Ala Ser Thr Leu Ala Glu Val Glu Arg Leu Lys
             340                 345                 350        
 Gly Leu Leu Gln Ser Gly Gln Ile Pro Gly Arg Glu Arg Arg Ser Gly
         355                 360                 365            
 Pro Thr Asp Asp Gly Glu Glu Glu Met Glu Glu Asp Thr Val Thr Asn
     370                 375                 380                
 Gly Ser
 385    



      <210> 231
      <211> 1239
      <212> PRT
      <213> Homo sapiens


      <400> 231
 Met Ala Ala Ala Phe Gly His Gly Gly Gly Leu Ala Phe Pro Gly Ala
   1               5                  10                  15    
 Pro Ala Val Ala Gly Ala Thr Ser Pro Ala Gly Pro Arg Glu Arg Arg
              20                  25                  30        
 Arg Gly Arg Gly Arg Lys Ser Arg Ala Val Thr Val Ala Gly Val Arg
          35                  40                  45            
 Pro Ser Ser Pro His Gly Leu Val Gly Ala Val Ser Val Gly Gly Ala
      50                  55                  60                
 Gly Val Met Ala Val Glu Thr Leu Ser Pro Asp Trp Glu Phe Asp Arg
  65                  70                  75                  80
 Val Asp Asp Gly Ser Gln Lys Ile His Ala Glu Val Gln Leu Lys Asn
                  85                  90                  95    
 Tyr Gly Lys Phe Leu Glu Glu Tyr Thr Ser Gln Leu Arg Arg Ile Glu
             100                 105                 110        
 Asp Ala Leu Asp Asp Ser Ile Gly Asp Val Trp Asp Phe Asn Leu Asp
         115                 120                 125            
 Pro Ile Ala Leu Lys Leu Leu Pro Tyr Glu Gln Ser Ser Leu Leu Glu
     130                 135                 140                
 Leu Ile Lys Thr Glu Asn Lys Val Leu Asn Lys Val Ile Thr Val Tyr
 145                 150                 155                 160
 Ala Ala Leu Cys Cys Glu Ile Lys Lys Leu Lys Tyr Glu Ala Glu Thr
                 165                 170                 175    
 Lys Phe Tyr Asn Gly Leu Leu Phe Tyr Gly Glu Gly Ala Thr Asp Ala
             180                 185                 190        
 Ser Met Val Glu Gly Asp Cys Gln Ile Gln Met Gly Arg Phe Ile Ser
         195                 200                 205            
 Phe Leu Gln Glu Leu Ser Cys Phe Val Thr Arg Cys Tyr Glu Val Val
     210                 215                 220                
 Met Asn Val Val His Gln Leu Ala Ala Leu Tyr Ile Ser Asn Lys Ile
 225                 230                 235                 240
 Ala Pro Lys Ile Ile Glu Thr Thr Gly Val His Phe Gln Thr Met Tyr
                 245                 250                 255    
 Glu His Leu Gly Glu Leu Leu Thr Val Leu Leu Thr Leu Asp Glu Ile
             260                 265                 270        
 Ile Asp Asn His Ile Thr Leu Lys Asp His Trp Thr Met Tyr Lys Arg
         275                 280                 285            
 Leu Leu Lys Ser Val His His Asn Pro Ser Lys Phe Gly Ile Gln Glu
     290                 295                 300                
 Glu Lys Leu Lys Pro Phe Glu Lys Phe Leu Leu Lys Leu Glu Gly Gln
 305                 310                 315                 320
 Leu Leu Asp Gly Met Ile Phe Gln Ala Cys Ile Glu Gln Gln Phe Asp
                 325                 330                 335    
 Ser Leu Asn Gly Gly Val Ser Val Ser Lys Asn Ser Thr Phe Ala Glu
             340                 345                 350        
 Glu Phe Ala His Ser Ile Arg Ser Ile Phe Ala Asn Val Glu Ala Lys
         355                 360                 365            
 Leu Gly Glu Pro Ser Glu Ile Asp Gln Arg Asp Lys Tyr Val Gly Ile
     370                 375                 380                
 Cys Gly Leu Phe Val Leu His Phe Gln Ile Phe Arg Thr Ile Asp Lys
 385                 390                 395                 400
 Lys Phe Tyr Lys Ser Leu Leu Asp Ile Cys Lys Lys Val Pro Ala Ile
                 405                 410                 415    
 Thr Leu Thr Ala Asn Ile Ile Trp Phe Pro Asp Asn Phe Leu Ile Gln
             420                 425                 430        
 Lys Ile Pro Ala Ala Ala Lys Leu Leu Asp Arg Lys Ser Leu Gln Ala
         435                 440                 445            
 Ile Lys Ile His Arg Asp Thr Phe Leu Gln Gln Lys Ala Gln Ser Leu
     450                 455                 460                
 Thr Lys Asp Val Gln Ser Tyr Tyr Val Phe Val Ser Ser Trp Met Met
 465                 470                 475                 480
 Lys Met Glu Ser Ile Leu Ser Lys Glu Gln Arg Met Asp Lys Phe Ala
                 485                 490                 495    
 Glu Asp Leu Thr Asn Arg Cys Asn Val Phe Ile Gln Gly Phe Leu Tyr
             500                 505                 510        
 Ala Tyr Ser Ile Ser Thr Ile Ile Lys Thr Thr Met Asn Leu Tyr Met
         515                 520                 525            
 Ser Met Gln Lys Pro Met Thr Lys Thr Ser Val Lys Ala Leu Cys Arg
     530                 535                 540                
 Leu Val Glu Leu Leu Lys Ala Ile Glu His Met Phe Tyr Arg Arg Ser
 545                 550                 555                 560
 Met Val Val Ala Asp Ser Val Ser His Ile Thr Gln His Leu Gln His
                 565                 570                 575    
 Gln Ala Leu His Ser Ile Ser Val Ala Lys Lys Arg Val Ile Ser Asp
             580                 585                 590        
 Lys Lys Tyr Ser Glu Gln Arg Leu Asp Val Leu Ser Ala Leu Val Leu
         595                 600                 605            
 Ala Glu Asn Thr Leu Asn Gly Pro Ser Thr Lys Gln Arg Arg Leu Ile
     610                 615                 620                
 Val Ser Leu Ala Leu Ser Val Gly Thr Gln Met Lys Thr Phe Lys Asp
 625                 630                 635                 640
 Glu Glu Leu Phe Pro Leu Gln Val Val Met Lys Lys Leu Asp Leu Ile
                 645                 650                 655    
 Ser Glu Leu Arg Glu Arg Val Gln Thr Gln Cys Asp Cys Cys Phe Leu
             660                 665                 670        
 Tyr Trp His Arg Ala Val Phe Pro Ile Tyr Leu Asp Asp Val Tyr Glu
         675                 680                 685            
 Asn Ala Val Asp Ala Ala Arg Leu His Tyr Met Phe Ser Ala Leu Arg
     690                 695                 700                
 Asp Cys Val Pro Ala Met Met His Ala Arg His Leu Glu Ser Tyr Glu
 705                 710                 715                 720
 Ile Leu Leu Asp Cys Tyr Asp Lys Glu Ile Met Glu Ile Leu Asn Glu
                 725                 730                 735    
 His Leu Leu Asp Lys Leu Cys Lys Glu Ile Glu Lys Asp Leu Arg Leu
             740                 745                 750        
 Ser Val His Thr His Leu Lys Leu Asp Asp Arg Asn Pro Phe Lys Val
         755                 760                 765            
 Gly Met Lys Asp Leu Ala Leu Phe Phe Ser Leu Asn Pro Ile Arg Phe
     770                 775                 780                
 Phe Asn Arg Phe Ile Asp Ile Arg Ala Tyr Val Thr His Tyr Leu Asp
 785                 790                 795                 800
 Lys Thr Phe Tyr Asn Leu Thr Thr Val Ala Leu His Asp Trp Ala Thr
                 805                 810                 815    
 Tyr Ser Glu Met Arg Asn Leu Ala Thr Gln Arg Tyr Gly Leu Val Met
             820                 825                 830        
 Thr Glu Ala His Leu Pro Ser Gln Thr Leu Glu Gln Gly Leu Asp Val
         835                 840                 845            
 Leu Glu Ile Met Arg Asn Ile His Ile Phe Val Ser Arg Tyr Leu Tyr
     850                 855                 860                
 Asn Leu Asn Asn Gln Ile Phe Ile Glu Arg Thr Ser Asn Asn Lys His
 865                 870                 875                 880
 Leu Asn Thr Ile Asn Ile Arg His Ile Ala Asn Ser Ile Arg Thr His
                 885                 890                 895    
 Gly Thr Gly Ile Met Asn Thr Thr Val Asn Phe Thr Tyr Gln Phe Leu
             900                 905                 910        
 Lys Lys Lys Phe Tyr Ile Phe Ser Gln Phe Met Tyr Asp Glu His Ile
         915                 920                 925            
 Lys Ser Arg Leu Ile Lys Asp Ile Arg Phe Phe Arg Glu Ile Lys Asp
     930                 935                 940                
 Gln Asn Asp His Lys Tyr Pro Phe Asp Arg Ala Glu Lys Phe Asn Arg
 945                 950                 955                 960
 Gly Ile Arg Lys Leu Gly Ile Thr Pro Glu Gly Gln Ser Tyr Leu Asp
                 965                 970                 975    
 Gln Phe Arg Gln Leu Ile Ser Gln Ile Gly Asn Ala Met Gly Tyr Val
             980                 985                 990        
 Arg Met Ile Arg Ser Gly Gly Leu His Cys Ser Ser Asn Ala Ile Arg
         995                1000                1005            
 Phe Val Pro Asp Leu Glu Asp Ile Val Asn Phe Glu Glu Leu Val Lys
    1010                1015                1020                
 Glu Glu Gly Leu Ala Glu Glu Thr Leu Lys Ala Ala Arg His Leu Asp
1025                1030                1035                1040
 Ser Val Leu Ser Asp His Thr Arg Asn Ser Ala Glu Gly Thr Glu Tyr
                1045                1050                1055    
 Phe Lys Met Leu Val Asp Val Phe Ala Pro Glu Phe Arg Arg Pro Lys
            1060                1065                1070        
 Asn Ile His Leu Arg Asn Phe Tyr Ile Ile Val Pro Pro Leu Thr Leu
        1075                1080                1085            
 Asn Phe Val Glu His Ser Ile Ser Cys Lys Glu Lys Leu Asn Lys Lys
    1090                1095                1100                
 Asn Lys Ile Gly Ala Ala Phe Thr Asp Asp Gly Phe Ala Met Gly Val
1105                1110                1115                1120
 Ala Tyr Ile Leu Lys Leu Leu Asp Gln Tyr Arg Glu Phe Asp Ser Leu
                1125                1130                1135    
 His Trp Phe Gln Ser Val Arg Glu Lys Tyr Leu Lys Glu Ile Arg Ala
            1140                1145                1150        
 Val Ala Lys Gln Gln Asn Val Gln Ser Ala Ser Gln Asp Glu Lys Leu
        1155                1160                1165            
 Leu Gln Thr Met Asn Leu Thr Gln Lys Arg Leu Asp Val Tyr Leu Gln
    1170                1175                1180                
 Glu Phe Glu Leu Leu Tyr Phe Ser Leu Ser Ser Ala Arg Ile Phe Phe
1185                1190                1195                1200
 Arg Ala Asp Lys Thr Ala Ala Glu Glu Asn Gln Glu Lys Lys Glu Lys
                1205                1210                1215    
 Glu Glu Glu Thr Lys Thr Ser Asn Gly Asp Leu Ser Asp Ser Thr Val
            1220                1225                1230        
 Ser Ala Asp Pro Val Val Lys
        1235                



      <210> 232
      <211> 127
      <212> PRT
      <213> Homo sapiens


      <400> 232
 Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala
   1               5                  10                  15    
 Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu
              20                  25                  30        
 Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val
          35                  40                  45            
 Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu
      50                  55                  60                
 Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln
  65                  70                  75                  80
 Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala
                  85                  90                  95    
 Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu
             100                 105                 110        
 Asp Leu His Ala Met Gly Ser Ala Arg Thr Asp Pro His Leu Met
         115                 120                 125        



      <210> 233
      <211> 308
      <212> PRT
      <213> Homo sapiens


      <400> 233
 Met Ala Pro Pro Ala Pro Gly Pro Ala Ser Gly Gly Ser Gly Glu Val
   1               5                  10                  15    
 Asp Glu Leu Phe Asp Val Lys Asn Ala Phe Tyr Ile Gly Ser Tyr Gln
              20                  25                  30        
 Gln Cys Ile Asn Glu Ala Gln Arg Val Lys Leu Ser Ser Pro Glu Arg
          35                  40                  45            
 Asp Val Glu Arg Asp Val Phe Leu Tyr Arg Ala Tyr Leu Ala Gln Arg
      50                  55                  60                
 Lys Phe Gly Val Val Leu Asp Glu Ile Lys Pro Ser Ser Ala Pro Glu
  65                  70                  75                  80
 Leu Gln Ala Val Arg Met Phe Ala Asp Tyr Leu Ala His Glu Ser Arg
                  85                  90                  95    
 Arg Asp Ser Ile Val Ala Glu Leu Asp Arg Glu Met Ser Arg Ser Val
             100                 105                 110        
 Asp Val Thr Asn Thr Thr Phe Leu Leu Met Ala Ala Ser Ile Tyr Leu
         115                 120                 125            
 His Asp Gln Asn Pro Asp Ala Ala Leu Arg Ala Leu His Gln Gly Asp
     130                 135                 140                
 Ser Leu Glu Cys Thr Ala Met Thr Val Gln Ile Leu Leu Lys Leu Asp
 145                 150                 155                 160
 Arg Leu Asp Leu Ala Arg Lys Glu Leu Lys Arg Met Gln Asp Leu Asp
                 165                 170                 175    
 Glu Asp Ala Thr Leu Thr Gln Leu Ala Thr Ala Trp Val Ser Leu Ala
             180                 185                 190        
 Thr Gly Gly Glu Lys Leu Gln Asp Ala Tyr Tyr Ile Phe Gln Glu Met
         195                 200                 205            
 Ala Asp Lys Cys Ser Pro Thr Leu Leu Leu Leu Asn Gly Gln Ala Ala
     210                 215                 220                
 Cys His Met Ala Gln Gly Arg Trp Glu Ala Ala Glu Gly Leu Leu Gln
 225                 230                 235                 240
 Glu Ala Leu Asp Lys Asp Ser Gly Tyr Pro Glu Thr Leu Val Asn Leu
                 245                 250                 255    
 Ile Val Leu Ser Gln His Leu Gly Lys Pro Pro Glu Val Thr Asn Arg
             260                 265                 270        
 Tyr Leu Ser Gln Leu Lys Asp Ala His Arg Ser His Pro Phe Ile Lys
         275                 280                 285            
 Glu Tyr Gln Ala Lys Glu Asn Asp Phe Asp Arg Leu Val Leu Gln Tyr
     290                 295                 300                
 Ala Pro Ser Ala
 305            



      <210> 234
      <211> 3256
      <212> PRT
      <213> Homo sapiens


      <400> 234
 Met Trp Pro Thr Arg Arg Leu Val Thr Ile Lys Arg Ser Gly Val Asp
   1               5                  10                  15    
 Gly Pro His Phe Pro Leu Ser Leu Ser Thr Cys Leu Phe Gly Arg Gly
              20                  25                  30        
 Ile Glu Cys Asp Ile Arg Ile Gln Leu Pro Val Val Ser Lys Gln His
          35                  40                  45            
 Cys Lys Ile Glu Ile His Glu Gln Glu Ala Ile Leu His Asn Phe Ser
      50                  55                  60                
 Ser Thr Asn Pro Thr Gln Val Asn Gly Ser Val Ile Asp Glu Pro Val
  65                  70                  75                  80
 Arg Leu Lys His Gly Asp Val Ile Thr Ile Ile Asp Arg Ser Phe Arg
                  85                  90                  95    
 Tyr Glu Asn Glu Ser Leu Gln Asn Gly Arg Lys Ser Thr Glu Phe Pro
             100                 105                 110        
 Arg Lys Ile Arg Glu Gln Glu Pro Ala Arg Arg Val Ser Arg Ser Ser
         115                 120                 125            
 Phe Ser Ser Asp Pro Asp Glu Lys Ala Gln Asp Ser Lys Ala Tyr Ser
     130                 135                 140                
 Lys Ile Thr Glu Gly Lys Val Ser Gly Asn Pro Gln Val His Ile Lys
 145                 150                 155                 160
 Asn Val Lys Glu Asp Ser Thr Ala Asp Asp Ser Lys Asp Ser Val Ala
                 165                 170                 175    
 Gln Gly Thr Thr Asn Val His Ser Ser Glu His Ala Gly Arg Asn Gly
             180                 185                 190        
 Arg Asn Ala Ala Asp Pro Ile Ser Gly Asp Phe Lys Glu Ile Ser Ser
         195                 200                 205            
 Val Lys Leu Val Ser Arg Tyr Gly Glu Leu Lys Ser Val Pro Thr Thr
     210                 215                 220                
 Gln Cys Leu Asp Asn Ser Lys Lys Asn Glu Ser Pro Phe Trp Lys Leu
 225                 230                 235                 240
 Tyr Glu Ser Val Lys Lys Glu Leu Asp Val Lys Ser Gln Lys Glu Asn
                 245                 250                 255    
 Val Leu Gln Tyr Cys Arg Lys Ser Gly Leu Gln Thr Asp Tyr Ala Thr
             260                 265                 270        
 Glu Lys Glu Ser Ala Asp Gly Leu Gln Gly Glu Thr Gln Leu Leu Val
         275                 280                 285            
 Ser Arg Lys Ser Arg Pro Lys Ser Gly Gly Ser Gly His Ala Val Ala
     290                 295                 300                
 Glu Pro Ala Ser Pro Glu Gln Glu Leu Asp Gln Asn Lys Gly Lys Gly
 305                 310                 315                 320
 Arg Asp Val Glu Ser Val Gln Thr Pro Ser Lys Ala Val Gly Ala Ser
                 325                 330                 335    
 Phe Pro Leu Tyr Glu Pro Ala Lys Met Lys Thr Pro Val Gln Tyr Ser
             340                 345                 350        
 Gln Gln Gln Asn Ser Pro Gln Lys His Lys Asn Lys Asp Leu Tyr Thr
         355                 360                 365            
 Thr Gly Arg Arg Glu Ser Val Asn Leu Gly Lys Ser Glu Gly Phe Lys
     370                 375                 380                
 Ala Gly Asp Lys Thr Leu Thr Pro Arg Lys Leu Ser Thr Arg Asn Arg
 385                 390                 395                 400
 Thr Pro Ala Lys Val Glu Asp Ala Ala Asp Ser Ala Thr Lys Pro Glu
                 405                 410                 415    
 Asn Leu Ser Ser Lys Thr Arg Gly Ser Ile Pro Thr Asp Val Glu Val
             420                 425                 430        
 Leu Pro Thr Glu Thr Glu Ile His Asn Glu Pro Phe Leu Thr Leu Trp
         435                 440                 445            
 Leu Thr Gln Val Glu Arg Lys Ile Gln Lys Asp Ser Leu Ser Lys Pro
     450                 455                 460                
 Glu Lys Leu Gly Thr Thr Ala Gly Gln Met Cys Ser Gly Leu Pro Gly
 465                 470                 475                 480
 Leu Ser Ser Val Asp Ile Asn Asn Phe Gly Asp Ser Ile Asn Glu Ser
                 485                 490                 495    
 Glu Gly Ile Pro Leu Lys Arg Arg Arg Val Ser Phe Gly Gly His Leu
             500                 505                 510        
 Arg Pro Glu Leu Phe Asp Glu Asn Leu Pro Pro Asn Thr Pro Leu Lys
         515                 520                 525            
 Arg Gly Glu Ala Pro Thr Lys Arg Lys Ser Leu Val Met His Thr Pro
     530                 535                 540                
 Pro Val Leu Lys Lys Ile Ile Lys Glu Gln Pro Gln Pro Ser Gly Lys
 545                 550                 555                 560
 Gln Glu Ser Gly Ser Glu Ile His Val Glu Val Lys Ala Gln Ser Leu
                 565                 570                 575    
 Val Ile Ser Pro Pro Ala Pro Ser Pro Arg Lys Thr Pro Val Ala Ser
             580                 585                 590        
 Asp Gln Arg Arg Arg Ser Cys Lys Thr Ala Pro Ala Ser Ser Ser Lys
         595                 600                 605            
 Ser Gln Thr Glu Val Pro Lys Arg Gly Gly Glu Arg Val Ala Thr Cys
     610                 615                 620                
 Leu Gln Lys Arg Val Ser Ile Ser Arg Ser Gln His Asp Ile Leu Gln
 625                 630                 635                 640
 Met Ile Cys Ser Lys Arg Arg Ser Gly Ala Ser Glu Ala Asn Leu Ile
                 645                 650                 655    
 Val Ala Lys Ser Trp Ala Asp Val Val Lys Leu Gly Ala Lys Gln Thr
             660                 665                 670        
 Gln Thr Lys Val Ile Lys His Gly Pro Gln Arg Ser Met Asn Lys Arg
         675                 680                 685            
 Gln Arg Arg Pro Ala Thr Pro Lys Lys Pro Val Gly Glu Val His Ser
     690                 695                 700                
 Gln Phe Ser Thr Gly His Ala Asn Ser Pro Cys Thr Ile Ile Ile Gly
 705                 710                 715                 720
 Lys Ala His Thr Glu Lys Val His Val Pro Ala Arg Pro Tyr Arg Val
                 725                 730                 735    
 Leu Asn Asn Phe Ile Ser Asn Gln Lys Met Asp Phe Lys Glu Asp Leu
             740                 745                 750        
 Ser Gly Ile Ala Glu Met Phe Lys Thr Pro Val Lys Glu Gln Pro Gln
         755                 760                 765            
 Leu Thr Ser Thr Cys His Ile Ala Ile Ser Asn Ser Glu Asn Leu Leu
     770                 775                 780                
 Gly Lys Gln Phe Gln Gly Thr Asp Ser Gly Glu Glu Pro Leu Leu Pro
 785                 790                 795                 800
 Thr Ser Glu Ser Phe Gly Gly Asn Val Phe Phe Ser Ala Gln Asn Ala
                 805                 810                 815    
 Ala Lys Gln Pro Ser Asp Lys Cys Ser Ala Ser Pro Pro Leu Arg Arg
             820                 825                 830        
 Gln Cys Ile Arg Glu Asn Gly Asn Val Ala Lys Thr Pro Arg Asn Thr
         835                 840                 845            
 Tyr Lys Met Thr Ser Leu Glu Thr Lys Thr Ser Asp Thr Glu Thr Glu
     850                 855                 860                
 Pro Ser Lys Thr Val Ser Thr Val Asn Arg Ser Gly Arg Ser Thr Glu
 865                 870                 875                 880
 Phe Arg Asn Ile Gln Lys Leu Pro Val Glu Ser Lys Ser Glu Glu Thr
                 885                 890                 895    
 Asn Thr Glu Ile Val Glu Cys Ile Leu Lys Arg Gly Gln Lys Ala Thr
             900                 905                 910        
 Leu Leu Gln Gln Arg Arg Glu Gly Glu Met Lys Glu Ile Glu Arg Pro
         915                 920                 925            
 Phe Glu Thr Tyr Lys Glu Asn Ile Glu Leu Lys Glu Asn Asp Glu Lys
     930                 935                 940                
 Met Lys Ala Met Lys Arg Ser Arg Thr Trp Gly Gln Lys Cys Ala Pro
 945                 950                 955                 960
 Met Ser Asp Leu Thr Asp Leu Lys Ser Leu Pro Asp Thr Glu Leu Met
                 965                 970                 975    
 Lys Asp Thr Ala Arg Gly Gln Asn Leu Leu Gln Thr Gln Asp His Ala
             980                 985                 990        
 Lys Ala Pro Lys Ser Glu Lys Gly Lys Ile Thr Lys Met Pro Cys Gln
         995                1000                1005            
 Ser Leu Gln Pro Glu Pro Ile Asn Thr Pro Thr His Thr Lys Gln Gln
    1010                1015                1020                
 Leu Lys Ala Ser Leu Gly Lys Val Gly Val Lys Glu Glu Leu Leu Ala
1025                1030                1035                1040
 Val Gly Lys Phe Thr Arg Thr Ser Gly Glu Thr Thr His Thr His Arg
                1045                1050                1055    
 Glu Pro Ala Gly Asp Gly Lys Ser Ile Arg Thr Phe Lys Glu Ser Pro
            1060                1065                1070        
 Lys Gln Ile Leu Asp Pro Ala Ala Arg Val Thr Gly Met Lys Lys Trp
        1075                1080                1085            
 Pro Arg Thr Pro Lys Glu Glu Ala Gln Ser Leu Glu Asp Leu Ala Gly
    1090                1095                1100                
 Phe Lys Glu Leu Phe Gln Thr Pro Gly Pro Ser Glu Glu Ser Met Thr
1105                1110                1115                1120
 Asp Glu Lys Thr Thr Lys Ile Ala Cys Lys Ser Pro Pro Pro Glu Ser
                1125                1130                1135    
 Val Asp Thr Pro Thr Ser Thr Lys Gln Trp Pro Lys Arg Ser Leu Arg
            1140                1145                1150        
 Lys Ala Asp Val Glu Glu Glu Phe Leu Ala Leu Arg Lys Leu Thr Pro
        1155                1160                1165            
 Ser Ala Gly Lys Ala Met Leu Thr Pro Lys Pro Ala Gly Gly Asp Glu
    1170                1175                1180                
 Lys Asp Ile Lys Ala Phe Met Gly Thr Pro Val Gln Lys Leu Asp Leu
1185                1190                1195                1200
 Ala Gly Thr Leu Pro Gly Ser Lys Arg Gln Leu Gln Thr Pro Lys Glu
                1205                1210                1215    
 Lys Ala Gln Ala Leu Glu Asp Leu Ala Gly Phe Lys Glu Leu Phe Gln
            1220                1225                1230        
 Thr Pro Gly His Thr Glu Glu Leu Val Ala Ala Gly Lys Thr Thr Lys
        1235                1240                1245            
 Ile Pro Cys Asp Ser Pro Gln Ser Asp Pro Val Asp Thr Pro Thr Ser
    1250                1255                1260                
 Thr Lys Gln Arg Pro Lys Arg Ser Ile Arg Lys Ala Asp Val Glu Gly
1265                1270                1275                1280
 Glu Leu Leu Ala Cys Arg Asn Leu Met Pro Ser Ala Gly Lys Ala Met
                1285                1290                1295    
 His Thr Pro Lys Pro Ser Val Gly Glu Glu Lys Asp Ile Ile Ile Phe
            1300                1305                1310        
 Val Gly Thr Pro Val Gln Lys Leu Asp Leu Thr Glu Asn Leu Thr Gly
        1315                1320                1325            
 Ser Lys Arg Arg Pro Gln Thr Pro Lys Glu Glu Ala Gln Ala Leu Glu
    1330                1335                1340                
 Asp Leu Thr Gly Phe Lys Glu Leu Phe Gln Thr Pro Gly His Thr Glu
1345                1350                1355                1360
 Glu Ala Val Ala Ala Gly Lys Thr Thr Lys Met Pro Cys Glu Ser Ser
                1365                1370                1375    
 Pro Pro Glu Ser Ala Asp Thr Pro Thr Ser Thr Arg Arg Gln Pro Lys
            1380                1385                1390        
 Thr Pro Leu Glu Lys Arg Asp Val Gln Lys Glu Leu Ser Ala Leu Lys
        1395                1400                1405            
 Lys Leu Thr Gln Thr Ser Gly Glu Thr Thr His Thr Asp Lys Val Pro
    1410                1415                1420                
 Gly Gly Glu Asp Lys Ser Ile Asn Ala Phe Arg Glu Thr Ala Lys Gln
1425                1430                1435                1440
 Lys Leu Asp Pro Ala Ala Ser Val Thr Gly Ser Lys Arg His Pro Lys
                1445                1450                1455    
 Thr Lys Glu Lys Ala Gln Pro Leu Glu Asp Leu Ala Gly Trp Lys Glu
            1460                1465                1470        
 Leu Phe Gln Thr Pro Val Cys Thr Asp Lys Pro Thr Thr His Glu Lys
        1475                1480                1485            
 Thr Thr Lys Ile Ala Cys Arg Ser Gln Pro Asp Pro Val Asp Thr Pro
    1490                1495                1500                
 Thr Ser Ser Lys Pro Gln Ser Lys Arg Ser Leu Arg Lys Val Asp Val
1505                1510                1515                1520
 Glu Glu Glu Phe Phe Ala Leu Arg Lys Arg Thr Pro Ser Ala Gly Lys
                1525                1530                1535    
 Ala Met His Thr Pro Lys Pro Ala Val Ser Gly Glu Lys Asn Ile Tyr
            1540                1545                1550        
 Ala Phe Met Gly Thr Pro Val Gln Lys Leu Asp Leu Thr Glu Asn Leu
        1555                1560                1565            
 Thr Gly Ser Lys Arg Arg Leu Gln Thr Pro Lys Glu Lys Ala Gln Ala
    1570                1575                1580                
 Leu Glu Asp Leu Ala Gly Phe Lys Glu Leu Phe Gln Thr Arg Gly His
1585                1590                1595                1600
 Thr Glu Glu Ser Met Thr Asn Asp Lys Thr Ala Lys Val Ala Cys Lys
                1605                1610                1615    
 Ser Ser Gln Pro Asp Leu Asp Lys Asn Pro Ala Ser Ser Lys Arg Arg
            1620                1625                1630        
 Leu Lys Thr Ser Leu Gly Lys Val Gly Val Lys Glu Glu Leu Leu Ala
        1635                1640                1645            
 Val Gly Lys Leu Thr Gln Thr Ser Gly Glu Thr Thr His Thr His Thr
    1650                1655                1660                
 Glu Pro Thr Gly Asp Gly Lys Ser Met Lys Ala Phe Met Glu Ser Pro
1665                1670                1675                1680
 Lys Gln Ile Leu Asp Ser Ala Ala Ser Leu Thr Gly Ser Lys Arg Gln
                1685                1690                1695    
 Leu Arg Thr Pro Lys Gly Lys Ser Glu Val Pro Glu Asp Leu Ala Gly
            1700                1705                1710        
 Phe Ile Glu Leu Phe Gln Thr Pro Ser His Thr Lys Glu Ser Met Thr
        1715                1720                1725            
 Asn Glu Lys Thr Thr Lys Val Ser Tyr Arg Ala Ser Gln Pro Asp Leu
    1730                1735                1740                
 Val Asp Thr Pro Thr Ser Ser Lys Pro Gln Pro Lys Arg Ser Leu Arg
1745                1750                1755                1760
 Lys Ala Asp Thr Glu Glu Glu Phe Leu Ala Phe Arg Lys Gln Thr Pro
                1765                1770                1775    
 Ser Ala Gly Lys Ala Met His Thr Pro Lys Pro Ala Val Gly Glu Glu
            1780                1785                1790        
 Lys Asp Ile Asn Thr Phe Leu Gly Thr Pro Val Gln Lys Leu Asp Gln
        1795                1800                1805            
 Pro Gly Asn Leu Pro Gly Ser Asn Arg Arg Leu Gln Thr Arg Lys Glu
    1810                1815                1820                
 Lys Ala Gln Ala Leu Glu Glu Leu Thr Gly Phe Arg Glu Leu Phe Gln
1825                1830                1835                1840
 Thr Pro Cys Thr Asp Asn Pro Thr Ala Asp Glu Lys Thr Thr Lys Lys
                1845                1850                1855    
 Ile Leu Cys Lys Ser Pro Gln Ser Asp Pro Ala Asp Thr Pro Thr Asn
            1860                1865                1870        
 Thr Lys Gln Arg Pro Lys Arg Ser Leu Lys Lys Ala Asp Val Glu Glu
        1875                1880                1885            
 Glu Phe Leu Ala Phe Arg Lys Leu Thr Pro Ser Ala Gly Lys Ala Met
    1890                1895                1900                
 His Thr Pro Lys Ala Ala Val Gly Glu Glu Lys Asp Ile Asn Thr Phe
1905                1910                1915                1920
 Val Gly Thr Pro Val Glu Lys Leu Asp Leu Leu Gly Asn Leu Pro Gly
                1925                1930                1935    
 Ser Lys Arg Arg Pro Gln Thr Pro Lys Glu Lys Ala Lys Ala Leu Glu
            1940                1945                1950        
 Asp Leu Ala Gly Phe Lys Glu Leu Phe Gln Thr Pro Gly His Thr Glu
        1955                1960                1965            
 Glu Ser Met Thr Asp Asp Lys Ile Thr Glu Val Ser Cys Lys Ser Pro
    1970                1975                1980                
 Gln Pro Asp Pro Val Lys Thr Pro Thr Ser Ser Lys Gln Arg Leu Lys
1985                1990                1995                2000
 Ile Ser Leu Gly Lys Val Gly Val Lys Glu Glu Val Leu Pro Val Gly
                2005                2010                2015    
 Lys Leu Thr Gln Thr Ser Gly Lys Thr Thr Gln Thr His Arg Glu Thr
            2020                2025                2030        
 Ala Gly Asp Gly Lys Ser Ile Lys Ala Phe Lys Glu Ser Ala Lys Gln
        2035                2040                2045            
 Met Leu Asp Pro Ala Asn Tyr Gly Thr Gly Met Glu Arg Trp Pro Arg
    2050                2055                2060                
 Thr Pro Lys Glu Glu Ala Gln Ser Leu Glu Asp Leu Ala Gly Phe Lys
2065                2070                2075                2080
 Glu Leu Phe Gln Thr Pro Asp His Thr Glu Glu Ser Thr Thr Asp Asp
                2085                2090                2095    
 Lys Thr Thr Lys Ile Ala Cys Lys Ser Pro Pro Pro Glu Ser Met Asp
            2100                2105                2110        
 Thr Pro Thr Ser Thr Arg Arg Arg Pro Lys Thr Pro Leu Gly Lys Arg
        2115                2120                2125            
 Asp Ile Val Glu Glu Leu Ser Ala Leu Lys Gln Leu Thr Gln Thr Thr
    2130                2135                2140                
 His Thr Asp Lys Val Pro Gly Asp Glu Asp Lys Gly Ile Asn Val Phe
2145                2150                2155                2160
 Arg Glu Thr Ala Lys Gln Lys Leu Asp Pro Ala Ala Ser Val Thr Gly
                2165                2170                2175    
 Ser Lys Arg Gln Pro Arg Thr Pro Lys Gly Lys Ala Gln Pro Leu Glu
            2180                2185                2190        
 Asp Leu Ala Gly Leu Lys Glu Leu Phe Gln Thr Pro Val Cys Thr Asp
        2195                2200                2205            
 Lys Pro Thr Thr His Glu Lys Thr Thr Lys Ile Ala Cys Arg Ser Pro
    2210                2215                2220                
 Gln Pro Asp Pro Val Gly Thr Pro Thr Ile Phe Lys Pro Gln Ser Lys
2225                2230                2235                2240
 Arg Ser Leu Arg Lys Ala Asp Val Glu Glu Glu Ser Leu Ala Leu Arg
                2245                2250                2255    
 Lys Arg Thr Pro Ser Val Gly Lys Ala Met Asp Thr Pro Lys Pro Ala
            2260                2265                2270        
 Gly Gly Asp Glu Lys Asp Met Lys Ala Phe Met Gly Thr Pro Val Gln
        2275                2280                2285            
 Lys Leu Asp Leu Pro Gly Asn Leu Pro Gly Ser Lys Arg Trp Pro Gln
    2290                2295                2300                
 Thr Pro Lys Glu Lys Ala Gln Ala Leu Glu Asp Leu Ala Gly Phe Lys
2305                2310                2315                2320
 Glu Leu Phe Gln Thr Pro Gly Thr Asp Lys Pro Thr Thr Asp Glu Lys
                2325                2330                2335    
 Thr Thr Lys Ile Ala Cys Lys Ser Pro Gln Pro Asp Pro Val Asp Thr
            2340                2345                2350        
 Pro Ala Ser Thr Lys Gln Arg Pro Lys Arg Asn Leu Arg Lys Ala Asp
        2355                2360                2365            
 Val Glu Glu Glu Phe Leu Ala Leu Arg Lys Arg Thr Pro Ser Ala Gly
    2370                2375                2380                
 Lys Ala Met Asp Thr Pro Lys Pro Ala Val Ser Asp Glu Lys Asn Ile
2385                2390                2395                2400
 Asn Thr Phe Val Glu Thr Pro Val Gln Lys Leu Asp Leu Leu Gly Asn
                2405                2410                2415    
 Leu Pro Gly Ser Lys Arg Gln Pro Gln Thr Pro Lys Glu Lys Ala Glu
            2420                2425                2430        
 Ala Leu Glu Asp Leu Val Gly Phe Lys Glu Leu Phe Gln Thr Pro Gly
        2435                2440                2445            
 His Thr Glu Glu Ser Met Thr Asp Asp Lys Ile Thr Glu Val Ser Cys
    2450                2455                2460                
 Lys Ser Pro Gln Pro Glu Ser Phe Lys Thr Ser Arg Ser Ser Lys Gln
2465                2470                2475                2480
 Arg Leu Lys Ile Pro Leu Val Lys Val Asp Met Lys Glu Glu Pro Leu
                2485                2490                2495    
 Ala Val Ser Lys Leu Thr Arg Thr Ser Gly Glu Thr Thr Gln Thr His
            2500                2505                2510        
 Thr Glu Pro Thr Gly Asp Ser Lys Ser Ile Lys Ala Phe Lys Glu Ser
        2515                2520                2525            
 Pro Lys Gln Ile Leu Asp Pro Ala Ala Ser Val Thr Gly Ser Arg Arg
    2530                2535                2540                
 Gln Leu Arg Thr Arg Lys Glu Lys Ala Arg Ala Leu Glu Asp Leu Val
2545                2550                2555                2560
 Asp Phe Lys Glu Leu Phe Ser Ala Pro Gly His Thr Glu Glu Ser Met
                2565                2570                2575    
 Thr Ile Asp Lys Asn Thr Lys Ile Pro Cys Lys Ser Pro Pro Pro Glu
            2580                2585                2590        
 Leu Thr Asp Thr Ala Thr Ser Thr Lys Arg Cys Pro Lys Thr Arg Pro
        2595                2600                2605            
 Arg Lys Glu Val Lys Glu Glu Leu Ser Ala Val Glu Arg Leu Thr Gln
    2610                2615                2620                
 Thr Ser Gly Gln Ser Thr His Thr His Lys Glu Pro Ala Ser Gly Asp
2625                2630                2635                2640
 Glu Gly Ile Lys Val Leu Lys Gln Arg Ala Lys Lys Lys Pro Asn Pro
                2645                2650                2655    
 Val Glu Glu Glu Pro Ser Arg Arg Arg Pro Arg Ala Pro Lys Glu Lys
            2660                2665                2670        
 Ala Gln Pro Leu Glu Asp Leu Ala Gly Phe Thr Glu Leu Ser Glu Thr
        2675                2680                2685            
 Ser Gly His Thr Gln Glu Ser Leu Thr Ala Gly Lys Ala Thr Lys Ile
    2690                2695                2700                
 Pro Cys Glu Ser Pro Pro Leu Glu Val Val Asp Thr Thr Ala Ser Thr
2705                2710                2715                2720
 Lys Arg His Leu Arg Thr Arg Val Gln Lys Val Gln Val Lys Glu Glu
                2725                2730                2735    
 Pro Ser Ala Val Lys Phe Thr Gln Thr Ser Gly Glu Thr Thr Asp Ala
            2740                2745                2750        
 Asp Lys Glu Pro Ala Gly Glu Asp Lys Gly Ile Lys Ala Leu Lys Glu
        2755                2760                2765            
 Ser Ala Lys Gln Thr Pro Ala Pro Ala Ala Ser Val Thr Gly Ser Arg
    2770                2775                2780                
 Arg Arg Pro Arg Ala Pro Arg Glu Ser Ala Gln Ala Ile Glu Asp Leu
2785                2790                2795                2800
 Ala Gly Phe Lys Asp Pro Ala Ala Gly His Thr Glu Glu Ser Met Thr
                2805                2810                2815    
 Asp Asp Lys Thr Thr Lys Ile Pro Cys Lys Ser Ser Pro Glu Leu Glu
            2820                2825                2830        
 Asp Thr Ala Thr Ser Ser Lys Arg Arg Pro Arg Thr Arg Ala Gln Lys
        2835                2840                2845            
 Val Glu Val Lys Glu Glu Leu Leu Ala Val Gly Lys Leu Thr Gln Thr
    2850                2855                2860                
 Ser Gly Glu Thr Thr His Thr Asp Lys Glu Pro Val Gly Glu Gly Lys
2865                2870                2875                2880
 Gly Thr Lys Ala Phe Lys Gln Pro Ala Lys Arg Asn Val Asp Ala Glu
                2885                2890                2895    
 Asp Val Ile Gly Ser Arg Arg Gln Pro Arg Ala Pro Lys Glu Lys Ala
            2900                2905                2910        
 Gln Pro Leu Glu Asp Leu Ala Ser Phe Gln Glu Leu Ser Gln Thr Pro
        2915                2920                2925            
 Gly His Thr Glu Glu Leu Ala Asn Gly Ala Ala Asp Ser Phe Thr Ser
    2930                2935                2940                
 Ala Pro Lys Gln Thr Pro Asp Ser Gly Lys Pro Leu Lys Ile Ser Arg
2945                2950                2955                2960
 Arg Val Leu Arg Ala Pro Lys Val Glu Pro Val Gly Asp Val Val Ser
                2965                2970                2975    
 Thr Arg Asp Pro Val Lys Ser Gln Ser Lys Ser Asn Thr Ser Leu Pro
            2980                2985                2990        
 Pro Leu Pro Phe Lys Arg Gly Gly Gly Lys Asp Gly Ser Val Thr Gly
        2995                3000                3005            
 Thr Lys Arg Leu Arg Cys Met Pro Ala Pro Glu Glu Ile Val Glu Glu
    3010                3015                3020                
 Leu Pro Ala Ser Lys Lys Gln Arg Val Ala Pro Arg Ala Arg Gly Lys
3025                3030                3035                3040
 Ser Ser Glu Pro Val Val Ile Met Lys Arg Ser Leu Arg Thr Ser Ala
                3045                3050                3055    
 Lys Arg Ile Glu Pro Ala Glu Glu Leu Asn Ser Asn Asp Met Lys Thr
            3060                3065                3070        
 Asn Lys Glu Glu His Lys Leu Gln Asp Ser Val Pro Glu Asn Lys Gly
        3075                3080                3085            
 Ile Ser Leu Arg Ser Arg Arg Gln Asp Lys Thr Glu Ala Glu Gln Gln
    3090                3095                3100                
 Ile Thr Glu Val Phe Val Leu Ala Glu Arg Ile Glu Ile Asn Arg Asn
3105                3110                3115                3120
 Glu Lys Lys Pro Met Lys Thr Ser Pro Glu Met Asp Ile Gln Asn Pro
                3125                3130                3135    
 Asp Asp Gly Ala Arg Lys Pro Ile Pro Arg Asp Lys Val Thr Glu Asn
            3140                3145                3150        
 Lys Arg Cys Leu Arg Ser Ala Arg Gln Asn Glu Ser Ser Gln Pro Lys
        3155                3160                3165            
 Val Ala Glu Glu Ser Gly Gly Gln Lys Ser Ala Lys Val Leu Met Gln
    3170                3175                3180                
 Asn Gln Lys Gly Lys Gly Glu Ala Gly Asn Ser Asp Ser Met Cys Leu
3185                3190                3195                3200
 Arg Ser Arg Lys Thr Lys Ser Gln Pro Ala Ala Ser Thr Leu Glu Ser
                3205                3210                3215    
 Glu Ser Val Gln Arg Val Thr Arg Ser Val Lys Arg Cys Ala Glu Asn
            3220                3225                3230        
 Pro Lys Lys Ala Glu Asp Asn Val Cys Val Lys Lys Ile Arg Thr Arg
        3235                3240                3245            
 Ser His Arg Asp Ser Glu Asp Ile
    3250                3255    



      <210> 235
      <211> 327
      <212> PRT
      <213> Homo sapiens


      <400> 235
 Met Gly Lys Trp Glu Phe Ile Ala Asn Glu Tyr Gly Gly Ala Tyr Ile
   1               5                  10                  15    
 Tyr Lys Phe Phe Arg Val Ala Glu Lys Gly His Ala Gln Asp Cys Asp
              20                  25                  30        
 Leu Asp Trp Asn Ala Leu Pro Glu Arg Gly Met Arg Arg Glu Val Val
          35                  40                  45            
 Val Ala Ser Glu Asp Glu Leu Ala Ala Ser Gly Leu Pro Ser Cys Asp
      50                  55                  60                
 Ala Ala Val Asn Leu Ala Gly Glu Asn Ile Leu Asn Pro Leu Arg Arg
  65                  70                  75                  80
 Ser Ala Arg Ala Leu Lys Leu Ile Pro Thr Arg Ala Gln Gly Gly Gln
                  85                  90                  95    
 Cys Pro Thr Asp Glu Asn Leu Trp Asn Glu Thr Phe Gln Lys Glu Val
             100                 105                 110        
 Ile Gly Ser Arg Leu Glu Thr Thr Gln Leu Leu Ala Lys Ala Ile Thr
         115                 120                 125            
 Lys Ala Pro Gln Pro Pro Lys Ala Trp Val Leu Val Thr Gly Val Ala
     130                 135                 140                
 Tyr Tyr Gln Pro Ser Leu Thr Ala Glu Tyr Asp Glu Asp Ser Pro Gly
 145                 150                 155                 160
 Gly Asp Phe Asp Phe Phe Ser Asn Leu Val Thr Lys Trp Glu Ala Ala
                 165                 170                 175    
 Ala Arg Leu Pro Gly Asp Ser Thr Arg Gln Val Val Val Arg Ser Gly
             180                 185                 190        
 Val Val Leu Gly Arg Gly Gly Gly Ala Met Gly His Met Leu Leu Pro
         195                 200                 205            
 Phe Arg Leu Gly Leu Gly Gly Pro Ile Gly Ser Gly His Gln Phe Phe
     210                 215                 220                
 Pro Trp Ile His Ile Gly Asp Leu Ala Gly Ile Leu Thr His Ala Leu
 225                 230                 235                 240
 Glu Ala Asn His Val His Gly Val Leu Asn Gly Val Ala Pro Ser Ser
                 245                 250                 255    
 Ala Thr Asn Ala Glu Phe Ala Gln Thr Phe Gly Ala Ala Leu Gly Arg
             260                 265                 270        
 Arg Ala Phe Ile Pro Leu Pro Ser Ala Val Val Gln Ala Val Phe Gly
         275                 280                 285            
 Arg Gln Arg Ala Ile Met Leu Leu Glu Gly Gln Lys Val Ile Pro Arg
     290                 295                 300                
 Arg Thr Leu Ala Thr Gly Tyr Gln Tyr Ser Phe Pro Glu Leu Gly Ala
 305                 310                 315                 320
 Ala Leu Lys Glu Ile Val Ala
                 325        



      <210> 236
      <211> 596
      <212> PRT
      <213> Homo sapiens


      <400> 236
 Met Pro Val Ile Pro Ala Thr Gln Glu Ala Glu Ala Glu Glu Ser Leu
   1               5                  10                  15    
 Asp Pro Gly Arg Arg Arg Leu Arg Thr Ile Gly Lys Leu Glu Pro Ser
              20                  25                  30        
 Tyr Val Ile Arg Lys Phe Leu Asp Ala Gln Arg Ile His Asn Leu Thr
          35                  40                  45            
 Ala Tyr Leu Gln Thr Leu His Arg Gln Ser Leu Ala Asn Ala Asp His
      50                  55                  60                
 Thr Thr Leu Leu Leu Asn Cys Tyr Thr Lys Leu Lys Asp Ser Ser Lys
  65                  70                  75                  80
 Leu Glu Glu Phe Ile Lys Lys Lys Ser Glu Ser Glu Val His Phe Asp
                  85                  90                  95    
 Val Glu Thr Ala Ile Lys Val Leu Arg Gln Ala Gly Tyr Tyr Ser His
             100                 105                 110        
 Ala Leu Tyr Leu Ala Glu Asn His Ala His His Glu Trp Tyr Leu Lys
         115                 120                 125            
 Ile Gln Leu Glu Asp Ile Lys Asn Tyr Gln Glu Ala Leu Arg Tyr Ile
     130                 135                 140                
 Gly Lys Leu Pro Phe Glu Gln Ala Glu Ser Asn Met Lys Arg Tyr Gly
 145                 150                 155                 160
 Lys Ile Leu Met His His Ile Pro Glu Gln Thr Thr Gln Leu Leu Lys
                 165                 170                 175    
 Gly Leu Cys Thr Asp Tyr Arg Pro Ser Leu Glu Gly Arg Ser Asp Arg
             180                 185                 190        
 Glu Ala Pro Gly Cys Arg Ala Asn Ser Glu Glu Phe Ile Pro Ile Phe
         195                 200                 205            
 Ala Asn Asn Pro Arg Glu Leu Lys Ala Phe Leu Glu His Met Ser Glu
     210                 215                 220                
 Val Gln Pro Asp Ser Pro Gln Gly Ile Tyr Asp Thr Leu Leu Glu Leu
 225                 230                 235                 240
 Arg Leu Gln Asn Trp Ala His Glu Lys Asp Pro Gln Val Lys Glu Lys
                 245                 250                 255    
 Leu His Ala Glu Ala Ile Ser Leu Leu Lys Ser Gly Arg Phe Cys Asp
             260                 265                 270        
 Val Phe Asp Lys Ala Leu Val Leu Cys Gln Met His Asp Phe Gln Asp
         275                 280                 285            
 Gly Val Leu Tyr Leu Tyr Glu Gln Gly Lys Leu Phe Gln Gln Ile Met
     290                 295                 300                
 His Tyr His Met Gln His Glu Gln Tyr Arg Gln Val Ile Ser Val Cys
 305                 310                 315                 320
 Glu Arg His Gly Glu Gln Asp Pro Ser Leu Trp Glu Gln Ala Leu Ser
                 325                 330                 335    
 Tyr Phe Ala Arg Lys Glu Glu Asp Cys Lys Glu Tyr Val Ala Ala Val
             340                 345                 350        
 Leu Lys His Ile Glu Asn Lys Asn Leu Met Pro Pro Leu Leu Gly Thr
         355                 360                 365            
 Trp Glu Asp Arg Trp Asp Glu Leu Arg Val Arg Arg Tyr Arg Glu Glu
     370                 375                 380                
 Thr Thr Arg Ile Arg Gln Glu Ile Gln Glu Leu Lys Ala Ser Pro Lys
 385                 390                 395                 400
 Ile Phe Gln Lys Thr Lys Cys Ser Ile Cys Asn Ser Ala Leu Glu Leu
                 405                 410                 415    
 Pro Ser Val His Phe Leu Cys Gly His Ser Phe His Gln His Cys Phe
             420                 425                 430        
 Glu Ser Tyr Ser Glu Ser Asp Ala Asp Cys Pro Thr Cys Leu Pro Glu
         435                 440                 445            
 Asn Arg Lys Val Met Asp Met Ile Arg Ala Gln Glu Gln Lys Arg Asp
     450                 455                 460                
 Leu His Asp Gln Phe Gln His Gln Pro Pro Lys Asp Asp Lys Lys Lys
 465                 470                 475                 480
 Lys Asp Ala Gly Lys Ser Ala Lys Lys Asp Lys Asp Pro Val Asn Lys
                 485                 490                 495    
 Ser Gly Gly Lys Ala Lys Lys Lys Lys Trp Ser Lys Gly Lys Val Arg
             500                 505                 510        
 Asp Lys Leu Asn Asn Leu Val Leu Phe Asp Lys Ala Thr Tyr Asp Lys
         515                 520                 525            
 Leu Cys Lys Glu Val Pro Asn Tyr Lys Leu Ile Thr Pro Ala Val Val
     530                 535                 540                
 Ser Glu Arg Leu Lys Ile Arg Gly Ser Leu Ala Arg Ala Ala Leu Gln
 545                 550                 555                 560
 Glu Leu Leu Ser Lys Gly Leu Ile Lys Leu Val Ser Lys His Arg Ala
                 565                 570                 575    
 Gln Val Ile Tyr Thr Arg Asn Thr Lys Gly Gly Asp Ala Pro Ala Ala
             580                 585                 590        
 Gly Glu Asp Ala
         595    



      <210> 237
      <211> 297
      <212> PRT
      <213> Homo sapiens


      <400> 237
 Met Ala Gly Ala Ala Thr Gln Ala Ser Leu Glu Ser Ala Pro Arg Ile
   1               5                  10                  15    
 Met Arg Leu Val Ala Glu Cys Ser Arg Ser Arg Ala Arg Ala Gly Glu
              20                  25                  30        
 Leu Trp Leu Pro His Gly Thr Val Ala Thr Pro Val Phe Met Pro Val
          35                  40                  45            
 Gly Thr Gln Ala Thr Met Lys Gly Ile Thr Thr Glu Gln Leu Asp Ala
      50                  55                  60                
 Leu Gly Cys Arg Ile Cys Leu Gly Asn Thr Tyr His Leu Gly Leu Arg
  65                  70                  75                  80
 Pro Gly Pro Glu Leu Ile Gln Lys Ala Asn Gly Leu His Gly Phe Met
                  85                  90                  95    
 Asn Trp Pro His Asn Leu Leu Thr Asp Ser Gly Gly Phe Gln Met Val
             100                 105                 110        
 Ser Leu Val Ser Leu Ser Glu Val Thr Glu Glu Gly Val Arg Phe Arg
         115                 120                 125            
 Ser Pro Tyr Asp Gly Asn Glu Thr Leu Leu Ser Pro Glu Lys Ser Val
     130                 135                 140                
 Gln Ile Gln Asn Ala Leu Gly Ser Asp Ile Ile Met Gln Leu Asp Asp
 145                 150                 155                 160
 Val Val Ser Ser Thr Val Thr Gly Pro Arg Val Glu Glu Ala Met Tyr
                 165                 170                 175    
 Arg Ser Ile Arg Trp Leu Asp Arg Cys Ile Ala Ala His Gln Arg Pro
             180                 185                 190        
 Asp Lys Gln Asn Leu Phe Ala Ile Ile Gln Gly Gly Leu Asp Ala Asp
         195                 200                 205            
 Leu Arg Ala Thr Cys Leu Glu Glu Met Thr Lys Arg Asp Val Pro Gly
     210                 215                 220                
 Phe Ala Ile Gly Gly Leu Ser Gly Gly Glu Ser Lys Ser Gln Phe Trp
 225                 230                 235                 240
 Arg Met Val Ala Leu Ser Thr Ser Arg Leu Pro Lys Asp Lys Pro Arg
                 245                 250                 255    
 Tyr Leu Met Gly Val Gly Tyr Val Val Asp Arg Glu Ala Arg Ala Leu
             260                 265                 270        
 Pro Val Gly Ser Gly Phe Leu Gly Thr Pro Tyr Pro Ala Trp Gly Gly
         275                 280                 285            
 Gly Ile Trp Gly Lys Arg Thr Gln Val
     290                 295        



      <210> 238
      <211> 156
      <212> PRT
      <213> Homo sapiens


      <400> 238
 Met Ala Ala Lys Val Phe Glu Ser Ile Gly Lys Phe Gly Leu Ala Leu
   1               5                  10                  15    
 Ala Val Ala Gly Gly Met Val Asn Ser Ala Leu Cys Asn Val Asp Ala
              20                  25                  30        
 Gly His Arg Ala Ala Ile Phe Asp Gln Phe Arg Gly Val Gln Asn Ile
          35                  40                  45            
 Val Val Gly Glu Gly Thr His Phe Leu Ile Pro Cys Val Gln Lys Pro
      50                  55                  60                
 Ile Ile Phe Asp Cys Cys Ser Gln Pro Arg Ser Ala Pro Val Ile Thr
  65                  70                  75                  80
 Gly Ser Lys Asp Leu Gln Asn Val Asn Ile Thr Leu Cys Ile Leu Phe
                  85                  90                  95    
 Arg Pro Ile Thr Ser Gln Leu Pro Arg Ile Phe Thr Ser Ile Gly Glu
             100                 105                 110        
 Asp Tyr Asp Glu Cys Val Leu Pro Phe Ile Thr Thr Glu Ile Leu Lys
         115                 120                 125            
 Ser Leu Val Ala Arg Phe Asp Ala Gly Glu Leu Ile Thr Gln Arg Glu
     130                 135                 140                
 Leu Val Ser Ser Gln Val Ser Asn Asn Leu Met Glu
 145                 150                 155    



      <210> 239
      <211> 487
      <212> PRT
      <213> Homo sapiens


      <400> 239
 Met Asp Gly Thr Glu Thr Arg Gln Arg Arg Leu Asp Ser Cys Gly Lys
   1               5                  10                  15    
 Pro Gly Glu Leu Gly Leu Pro His Pro Leu Ser Thr Gly Gly Leu Pro
              20                  25                  30        
 Val Ala Ser Glu Asp Gly Ala Leu Arg Ala Pro Glu Ser Gln Ser Val
          35                  40                  45            
 Thr Pro Lys Pro Leu Glu Thr Glu Pro Ser Arg Glu Thr Ala Trp Ser
      50                  55                  60                
 Ile Gly Leu Gln Val Thr Val Pro Phe Met Phe Ala Gly Leu Gly Leu
  65                  70                  75                  80
 Ser Trp Ala Gly Met Leu Leu Asp Tyr Phe Gln His Trp Pro Val Phe
                  85                  90                  95    
 Val Glu Val Lys Asp Leu Leu Thr Leu Val Pro Pro Leu Val Gly Leu
             100                 105                 110        
 Lys Gly Asn Leu Glu Met Thr Leu Ala Ser Arg Leu Ser Thr Ala Ala
         115                 120                 125            
 Asn Thr Gly Gln Ile Asp Asp Pro Gln Glu Gln His Arg Val Ile Ser
     130                 135                 140                
 Ser Asn Leu Ala Leu Ile Gln Val Gln Ala Thr Val Val Gly Leu Leu
 145                 150                 155                 160
 Ala Ala Val Ala Ala Leu Leu Leu Gly Val Val Ser Arg Glu Glu Val
                 165                 170                 175    
 Asp Val Ala Lys Val Glu Leu Leu Cys Ala Ser Ser Val Leu Thr Ala
             180                 185                 190        
 Phe Leu Ala Ala Phe Ala Leu Gly Val Leu Met Val Cys Ile Val Ile
         195                 200                 205            
 Gly Ala Arg Lys Leu Gly Val Asn Pro Asp Asn Ile Ala Thr Pro Ile
     210                 215                 220                
 Ala Ala Ser Leu Gly Asp Leu Ile Thr Leu Ser Ile Leu Ala Leu Val
 225                 230                 235                 240
 Ser Ser Phe Phe Tyr Arg His Lys Asp Ser Arg Tyr Leu Thr Pro Leu
                 245                 250                 255    
 Val Cys Leu Ser Phe Ala Ala Leu Thr Pro Val Trp Val Leu Ile Ala
             260                 265                 270        
 Lys Gln Ser Pro Pro Ile Val Lys Ile Leu Lys Phe Gly Trp Phe Pro
         275                 280                 285            
 Ile Ile Leu Ala Met Val Ile Ser Ser Phe Gly Gly Leu Ile Leu Ser
     290                 295                 300                
 Lys Thr Val Ser Lys Gln Gln Tyr Lys Gly Met Ala Ile Phe Thr Pro
 305                 310                 315                 320
 Val Ile Cys Gly Val Gly Gly Asn Leu Val Ala Ile Gln Thr Ser Arg
                 325                 330                 335    
 Ile Ser Thr Tyr Leu His Met Trp Ser Ala Pro Gly Val Leu Pro Leu
             340                 345                 350        
 Gln Met Lys Lys Phe Trp Pro Asn Pro Cys Ser Thr Phe Cys Thr Ser
         355                 360                 365            
 Glu Ile Asn Ser Met Ser Ala Arg Val Leu Leu Leu Leu Val Val Pro
     370                 375                 380                
 Gly His Leu Ile Phe Phe Tyr Ile Ile Tyr Leu Val Glu Gly Gln Ser
 385                 390                 395                 400
 Val Ile Asn Ser Gln Thr Phe Val Val Leu Tyr Leu Leu Ala Gly Leu
                 405                 410                 415    
 Ile Gln Val Thr Ile Leu Leu Tyr Leu Ala Glu Val Met Val Arg Leu
             420                 425                 430        
 Thr Trp His Gln Ala Leu Asp Pro Asp Asn His Cys Ile Pro Tyr Leu
         435                 440                 445            
 Thr Gly Leu Gly Asp Leu Leu Gly Thr Gly Leu Leu Ala Leu Cys Phe
     450                 455                 460                
 Phe Thr Asp Trp Leu Leu Lys Ser Lys Ala Glu Leu Gly Gly Ile Ser
 465                 470                 475                 480
 Glu Leu Ala Ser Gly Pro Pro
                 485        



      <210> 240
      <211> 507
      <212> PRT
      <213> Homo sapiens


      <400> 240
 Met Cys Asp Ile Glu Glu Ala Thr Asn Gln Leu Leu Asp Val Asn Leu
   1               5                  10                  15    
 His Glu Asn Gln Lys Ser Val Gln Val Thr Glu Ser Asp Leu Gly Ser
              20                  25                  30        
 Glu Ser Glu Leu Leu Val Thr Ile Gly Ala Thr Val Pro Thr Gly Phe
          35                  40                  45            
 Glu Gln Thr Ala Ala Asp Glu Val Arg Glu Lys Leu Gly Ser Ser Cys
      50                  55                  60                
 Lys Ile Ser Arg Asp Arg Gly Lys Ile Tyr Phe Val Ile Ser Val Glu
  65                  70                  75                  80
 Ser Leu Ala Gln Val His Cys Leu Arg Ser Val Asp Asn Leu Phe Val
                  85                  90                  95    
 Val Val Gln Glu Phe Gln Asp Tyr Gln Phe Lys Gln Thr Lys Glu Glu
             100                 105                 110        
 Val Leu Lys Asp Phe Glu Asp Leu Ala Gly Lys Leu Pro Trp Ser Asn
         115                 120                 125            
 Pro Leu Lys Val Trp Lys Ile Asn Ala Ser Phe Lys Lys Lys Lys Ala
     130                 135                 140                
 Lys Arg Lys Lys Ile Asn Gln Asn Ser Ser Lys Glu Lys Ile Asn Asn
 145                 150                 155                 160
 Gly Gln Glu Val Lys Ile Asp Gln Arg Asn Val Lys Lys Glu Phe Thr
                 165                 170                 175    
 Ser His Ala Leu Asp Ser His Ile Leu Asp Tyr Tyr Glu Asn Pro Ala
             180                 185                 190        
 Ile Lys Glu Asp Val Ser Thr Leu Ile Gly Asp Asp Leu Ala Ser Cys
         195                 200                 205            
 Lys Asp Glu Thr Asp Glu Ser Ser Lys Glu Glu Thr Glu Pro Gln Val
     210                 215                 220                
 Leu Lys Phe Arg Val Thr Cys Asn Arg Ala Gly Glu Lys His Cys Phe
 225                 230                 235                 240
 Thr Ser Asn Glu Ala Ala Arg Asp Phe Gly Gly Ala Val Gln Asp Tyr
                 245                 250                 255    
 Phe Lys Trp Lys Ala Asp Met Thr Asn Phe Asp Val Glu Val Leu Leu
             260                 265                 270        
 Asn Ile His Asp Asn Glu Val Ile Val Gly Ile Ala Leu Thr Glu Glu
         275                 280                 285            
 Ser Leu His Arg Arg Asn Ile Thr His Phe Gly Pro Thr Thr Leu Arg
     290                 295                 300                
 Ser Thr Leu Ala Tyr Gly Met Leu Arg Leu Cys Asp Pro Leu Pro Tyr
 305                 310                 315                 320
 Asp Ile Ile Val Asp Pro Met Cys Gly Thr Gly Ala Ile Pro Ile Glu
                 325                 330                 335    
 Gly Ala Thr Glu Trp Ser Asp Cys Phe His Ile Ala Gly Asp Asn Asn
             340                 345                 350        
 Pro Leu Ala Val Asn Arg Ala Ala Asn Asn Ile Ala Ser Leu Leu Thr
         355                 360                 365            
 Lys Ser Gln Ile Lys Glu Gly Lys Pro Ser Trp Gly Leu Pro Ile Asp
     370                 375                 380                
 Ala Val Gln Trp Asp Ile Cys Asn Leu Pro Leu Arg Thr Gly Ser Val
 385                 390                 395                 400
 Asp Ile Ile Val Thr Asp Leu Pro Phe Gly Lys Arg Met Gly Ser Lys
                 405                 410                 415    
 Lys Arg Asn Trp Asn Leu Tyr Pro Ala Cys Leu Arg Glu Met Ser Arg
             420                 425                 430        
 Val Cys Thr Pro Thr Thr Gly Arg Ala Val Leu Leu Thr Gln Asp Thr
         435                 440                 445            
 Lys Cys Phe Thr Lys Ala Leu Ser Gly Met Arg His Val Trp Arg Lys
     450                 455                 460                
 Val Asp Thr Val Trp Val Asn Val Gly Gly Leu Arg Ala Ala Val Tyr
 465                 470                 475                 480
 Val Leu Ile Arg Thr Pro Gln Ala Phe Val His Pro Ser Glu Gln Asp
                 485                 490                 495    
 Gly Glu Arg Gly Thr Leu Trp Gln Cys Lys Glu
             500                 505        



      <210> 241
      <211> 266
      <212> PRT
      <213> Homo sapiens


      <400> 241
 Met Arg Val Thr Leu Ala Thr Ile Ala Trp Met Val Ser Phe Val Ser
   1               5                  10                  15    
 Asn Tyr Ser His Thr Ala Asn Ile Leu Pro Asp Ile Glu Asn Glu Asp
              20                  25                  30        
 Phe Ile Lys Asp Cys Val Arg Ile His Asn Lys Phe Arg Ser Glu Val
          35                  40                  45            
 Lys Pro Thr Ala Ser Asp Met Leu Tyr Met Thr Trp Asp Pro Ala Leu
      50                  55                  60                
 Ala Gln Ile Ala Lys Ala Trp Ala Ser Asn Cys Gln Phe Ser His Asn
  65                  70                  75                  80
 Thr Arg Leu Lys Pro Pro His Lys Leu His Pro Asn Phe Thr Ser Leu
                  85                  90                  95    
 Gly Glu Asn Ile Trp Thr Gly Ser Val Pro Ile Phe Ser Val Ser Ser
             100                 105                 110        
 Ala Ile Thr Asn Trp Tyr Asp Glu Ile Gln Asp Tyr Asp Phe Lys Thr
         115                 120                 125            
 Arg Ile Cys Lys Lys Val Cys Gly His Tyr Thr Gln Val Val Trp Ala
     130                 135                 140                
 Asp Ser Tyr Lys Val Gly Cys Ala Val Gln Phe Cys Pro Lys Val Ser
 145                 150                 155                 160
 Gly Phe Asp Ala Leu Ser Asn Gly Ala His Phe Ile Cys Asn Tyr Gly
                 165                 170                 175    
 Pro Gly Gly Asn Tyr Pro Thr Trp Pro Tyr Lys Arg Gly Ala Thr Cys
             180                 185                 190        
 Ser Ala Cys Pro Asn Asn Asp Lys Cys Leu Asp Asn Leu Cys Val Asn
         195                 200                 205            
 Arg Gln Arg Asp Gln Val Lys Arg Tyr Tyr Ser Val Val Tyr Pro Gly
     210                 215                 220                
 Trp Pro Ile Tyr Pro Arg Asn Arg Tyr Thr Ser Leu Phe Leu Ile Val
 225                 230                 235                 240
 Asn Ser Val Ile Leu Ile Leu Ser Val Ile Ile Thr Ile Leu Val Gln
                 245                 250                 255    
 His Lys Tyr Pro Asn Leu Val Leu Leu Asp
             260                 265    



      <210> 242
      <211> 890
      <212> PRT
      <213> Homo sapiens


      <400> 242
 Met Asn Tyr Val Gly Gln Leu Ala Gly Gln Val Phe Val Thr Val Lys
   1               5                  10                  15    
 Glu Leu Tyr Lys Gly Leu Asn Pro Ala Thr Leu Ser Gly Cys Ile Asp
              20                  25                  30        
 Ile Ile Val Ile Arg Gln Pro Asn Gly Asn Leu Gln Cys Ser Pro Phe
          35                  40                  45            
 His Val Arg Phe Gly Lys Met Gly Val Leu Arg Ser Arg Glu Lys Val
      50                  55                  60                
 Val Asp Ile Glu Ile Asn Gly Glu Ser Val Asp Leu His Met Lys Leu
  65                  70                  75                  80
 Gly Asp Asn Gly Glu Ala Phe Phe Val Gln Glu Thr Asp Asn Asp Gln
                  85                  90                  95    
 Glu Val Ile Pro Met His Leu Ala Thr Ser Pro Ile Leu Ser Glu Gly
             100                 105                 110        
 Ala Ser Arg Met Glu Cys Gln Leu Lys Arg Gly Ser Val Asp Arg Met
         115                 120                 125            
 Arg Gly Leu Asp Pro Ser Thr Pro Ala Gln Val Ile Ala Pro Ser Glu
     130                 135                 140                
 Thr Pro Ser Ser Ser Ser Val Val Lys Lys Arg Arg Lys Arg Arg Arg
 145                 150                 155                 160
 Lys Ser Gln Leu Asp Ser Leu Lys Arg Asp Asp Asn Met Asn Thr Ser
                 165                 170                 175    
 Glu Asp Glu Asp Met Phe Pro Ile Glu Met Ser Ser Asp Glu Ala Met
             180                 185                 190        
 Glu Leu Leu Glu Ser Ser Arg Thr Leu Pro Asn Asp Ile Pro Pro Phe
         195                 200                 205            
 Gln Asp Asp Ile Pro Glu Glu Asn Leu Ser Leu Ala Val Ile Tyr Pro
     210                 215                 220                
 Gln Ser Ala Ser Tyr Pro Asn Ser Asp Arg Glu Trp Ser Pro Thr Pro
 225                 230                 235                 240
 Ser Pro Ser Gly Ser Arg Pro Ser Thr Pro Lys Ser Asp Ser Glu Leu
                 245                 250                 255    
 Val Ser Lys Ser Thr Glu Arg Thr Gly Gln Lys Asn Pro Glu Met Leu
             260                 265                 270        
 Trp Leu Trp Gly Glu Leu Pro Gln Ala Ala Lys Ser Ser Ser Pro His
         275                 280                 285            
 Lys Met Lys Glu Ser Ser Pro Leu Ser Ser Arg Lys Ile Cys Asp Lys
     290                 295                 300                
 Ser His Phe Gln Ala Ile His Ser Glu Ser Ser Asp Thr Phe Ser Asp
 305                 310                 315                 320
 Gln Ser Pro Thr Leu Val Gly Gly Ala Leu Leu Asp Gln Asn Lys Pro
                 325                 330                 335    
 Gln Thr Glu Met Gln Phe Val Asn Glu Glu Asp Leu Glu Thr Leu Gly
             340                 345                 350        
 Ala Ala Ala Pro Leu Leu Pro Met Ile Glu Glu Leu Lys Pro Pro Ser
         355                 360                 365            
 Ala Ser Val Val Gln Thr Ala Asn Lys Thr Asp Ser Pro Ser Arg Lys
     370                 375                 380                
 Arg Asp Lys Arg Ser Arg His Leu Gly Ala Asp Gly Val Tyr Leu Asp
 385                 390                 395                 400
 Asp Leu Thr Asp Met Asp Pro Glu Val Ala Ala Leu Tyr Phe Pro Lys
                 405                 410                 415    
 Asn Gly Asp Pro Ser Gly Leu Ala Lys His Ala Ser Asp Asn Gly Ala
             420                 425                 430        
 Arg Ser Ala Asn Gln Ser Pro Gln Ser Val Gly Ser Ser Gly Val Asp
         435                 440                 445            
 Ser Gly Val Glu Ser Thr Ser Asp Gly Leu Arg Asp Leu Pro Ser Ile
     450                 455                 460                
 Ala Ile Ser Leu Cys Gly Gly Leu Ser Asp His Arg Glu Ile Thr Lys
 465                 470                 475                 480
 Asp Ala Phe Leu Glu Gln Ala Val Ser Tyr Gln Gln Phe Val Asp Asn
                 485                 490                 495    
 Pro Ala Ile Ile Asp Asp Pro Asn Leu Val Val Lys Ile Gly Ser Lys
             500                 505                 510        
 Tyr Tyr Asn Trp Thr Thr Ala Ala Pro Leu Leu Leu Ala Met Gln Ala
         515                 520                 525            
 Phe Gln Lys Pro Leu Pro Lys Ala Thr Val Glu Ser Ile Met Arg Asp
     530                 535                 540                
 Lys Met Pro Lys Lys Gly Gly Arg Trp Trp Phe Ser Trp Arg Gly Arg
 545                 550                 555                 560
 Asn Thr Thr Ile Lys Glu Glu Ser Lys Pro Glu Gln Cys Leu Ala Gly
                 565                 570                 575    
 Lys Ala His Ser Thr Gly Glu Gln Pro Pro Gln Leu Ser Leu Ala Thr
             580                 585                 590        
 Arg Val Lys His Glu Ser Ser Ser Ser Asp Glu Glu Arg Ala Ala Ala
         595                 600                 605            
 Lys Pro Ser Asn Ala Gly His Leu Pro Leu Leu Pro Asn Val Ser Tyr
     610                 615                 620                
 Lys Lys Thr Leu Arg Leu Thr Ser Glu Gln Leu Lys Ser Leu Lys Leu
 625                 630                 635                 640
 Lys Asn Gly Pro Asn Asp Val Val Phe Ser Val Thr Thr Gln Tyr Gln
                 645                 650                 655    
 Gly Thr Cys Arg Cys Glu Gly Thr Ile Tyr Leu Trp Asn Trp Asp Asp
             660                 665                 670        
 Lys Val Ile Ile Ser Asp Ile Asp Gly Thr Ile Thr Arg Ser Asp Thr
         675                 680                 685            
 Leu Gly His Ile Leu Pro Thr Leu Gly Lys Asp Trp Thr His Gln Gly
     690                 695                 700                
 Ile Ala Lys Leu Tyr His Lys Val Ser Gln Asn Gly Tyr Lys Phe Leu
 705                 710                 715                 720
 Tyr Cys Ser Ala Arg Ala Ile Gly Met Ala Asp Met Thr Arg Gly Tyr
                 725                 730                 735    
 Leu His Trp Val Asn Glu Arg Gly Thr Val Leu Pro Gln Gly Pro Leu
             740                 745                 750        
 Leu Leu Ser Pro Ser Ser Leu Phe Ser Ala Leu His Arg Glu Val Ile
         755                 760                 765            
 Glu Lys Lys Pro Glu Lys Phe Lys Val Gln Cys Leu Thr Asp Ile Lys
     770                 775                 780                
 Asn Leu Phe Phe Pro Asn Thr Glu Pro Phe Tyr Ala Ala Phe Gly Asn
 785                 790                 795                 800
 Arg Pro Ala Asp Val Tyr Ser Tyr Lys Gln Val Gly Val Ser Leu Asn
                 805                 810                 815    
 Arg Ile Phe Thr Val Asn Pro Lys Gly Glu Leu Val Gln Glu His Ala
             820                 825                 830        
 Lys Thr Asn Ile Ser Ser Tyr Val Arg Leu Cys Glu Val Val Asp His
         835                 840                 845            
 Val Phe Pro Leu Leu Lys Arg Ser His Ser Ser Asp Phe Pro Cys Ser
     850                 855                 860                
 Asp Thr Phe Ser Asn Phe Thr Phe Trp Arg Glu Pro Leu Pro Pro Phe
 865                 870                 875                 880
 Glu Asn Gln Asp Ile His Ser Ala Ser Ala
                 885                 890



      <210> 243
      <211> 132
      <212> PRT
      <213> Homo sapiens


      <400> 243
 Met Asn His Ile Val Gln Thr Phe Ser Pro Val Asn Ser Gly Gln Pro
   1               5                  10                  15    
 Pro Asn Tyr Glu Met Leu Lys Glu Glu Gln Glu Val Ala Met Leu Gly
              20                  25                  30        
 Ala Pro His Asn Pro Ala Pro Pro Thr Ser Thr Val Ile His Ile Arg
          35                  40                  45            
 Ser Glu Thr Ser Val Pro Asp His Val Val Trp Ser Leu Phe Asn Thr
      50                  55                  60                
 Leu Phe Met Asn Thr Cys Cys Leu Gly Phe Ile Ala Phe Ala Tyr Ser
  65                  70                  75                  80
 Val Lys Ser Arg Asp Arg Lys Met Val Gly Asp Val Thr Gly Ala Gln
                  85                  90                  95    
 Ala Tyr Ala Ser Thr Ala Lys Cys Leu Asn Ile Trp Ala Leu Ile Leu
             100                 105                 110        
 Gly Ile Phe Met Thr Ile Leu Leu Val Ile Ile Pro Val Leu Val Val
         115                 120                 125            
 Gln Ala Gln Arg
     130        



      <210> 244
      <211> 211
      <212> PRT
      <213> Homo sapiens


      <400> 244
 Met Ala Pro Ser Arg Asn Gly Met Val Leu Lys Pro His Phe His Lys
   1               5                  10                  15    
 Asp Trp Gln Arg Arg Val Ala Thr Trp Phe Asn Gln Pro Ala Arg Lys
              20                  25                  30        
 Ile Arg Arg Arg Lys Ala Arg Gln Ala Lys Ala Arg Arg Ile Ala Pro
          35                  40                  45            
 Arg Pro Ala Ser Gly Pro Ile Arg Pro Ile Val Arg Cys Pro Thr Val
      50                  55                  60                
 Arg Tyr His Thr Lys Val Arg Ala Gly Arg Gly Phe Ser Leu Glu Glu
  65                  70                  75                  80
 Leu Arg Val Ala Gly Ile His Lys Lys Val Ala Arg Thr Ile Gly Ile
                  85                  90                  95    
 Ser Val Asp Pro Arg Arg Arg Asn Lys Ser Thr Glu Ser Leu Gln Ala
             100                 105                 110        
 Asn Val Gln Arg Leu Lys Glu Tyr Arg Ser Lys Leu Ile Leu Phe Pro
         115                 120                 125            
 Arg Lys Pro Ser Ala Pro Lys Lys Gly Asp Ser Ser Ala Glu Glu Leu
     130                 135                 140                
 Lys Leu Ala Thr Gln Leu Thr Gly Pro Val Met Pro Val Arg Asn Val
 145                 150                 155                 160
 Tyr Lys Lys Glu Lys Ala Arg Val Ile Thr Glu Glu Glu Lys Asn Phe
                 165                 170                 175    
 Lys Ala Phe Ala Ser Leu Arg Met Ala Arg Ala Asn Ala Arg Leu Phe
             180                 185                 190        
 Gly Ile Arg Ala Lys Arg Ala Lys Glu Ala Ala Glu Gln Asp Val Glu
         195                 200                 205            
 Lys Lys Lys
     210    



      <210> 245
      <211> 257
      <212> PRT
      <213> Homo sapiens


      <400> 245
 Met Val Gln Leu Arg Pro Arg Ala Ser Arg Ala Pro Ala Ser Ala Glu
   1               5                  10                  15    
 Ala Met Val Asp Glu Gly Gln Leu Ala Ser Glu Glu Glu Glu Ala Glu
              20                  25                  30        
 His Gly Leu Leu Leu Gly Gln Pro Ser Ser Gly Ala Ala Ala Glu Pro
          35                  40                  45            
 Leu Glu Glu Asp Asp Glu Gly Asp Asp Glu Phe Asp Asp Glu Ala Pro
      50                  55                  60                
 Glu Glu Leu Thr Phe Ala Ser Ala Gln Ala Glu Ala Arg Glu Glu Glu
  65                  70                  75                  80
 Arg Arg Val Arg Glu Thr Val Arg Arg Asp Lys Thr Leu Leu Lys Glu
                  85                  90                  95    
 Lys Arg Lys Arg Arg Glu Glu Leu Phe Ile Glu Gln Lys Lys Arg Lys
             100                 105                 110        
 Leu Leu Pro Asp Thr Ile Leu Glu Lys Leu Thr Thr Ala Ser Gln Thr
         115                 120                 125            
 Asn Ile Lys Lys Ser Pro Gly Lys Val Lys Glu Val Asn Leu Gln Lys
     130                 135                 140                
 Lys Asn Glu Asp Cys Glu Lys Gly Asn Asp Ser Lys Lys Val Lys Val
 145                 150                 155                 160
 Gln Lys Val Gln Ser Val Ser Gln Asn Lys Ser Tyr Leu Ala Val Arg
                 165                 170                 175    
 Leu Lys Asp Gln Asp Leu Arg Asp Ser Arg Gln Gln Ala Ala Gln Ala
             180                 185                 190        
 Phe Ile His Asn Ser Leu Tyr Gly Pro Gly Thr Asn Arg Thr Thr Val
         195                 200                 205            
 Asn Lys Phe Leu Ser Leu Ala Asn Lys Arg Leu Pro Val Lys Arg Ala
     210                 215                 220                
 Ala Val Gln Phe Leu Asn Asn Ala Trp Gly Ile Gln Lys Lys Gln Asn
 225                 230                 235                 240
 Ala Lys Arg Phe Lys Arg Arg Trp Met Val Arg Lys Met Lys Thr Lys
                 245                 250                 255    
 Lys
    



      <210> 246
      <211> 217
      <212> PRT
      <213> Homo sapiens


      <400> 246
 Met Pro Thr Pro His Glu Ala Glu Lys Gln Ile Thr Gly Pro Glu Glu
   1               5                  10                  15    
 Ala Asp Arg Pro Pro Ser Met Ser Ser His Asp Thr Ala Ser Pro Ala
              20                  25                  30        
 Ala Pro Ser Arg Asn Pro Cys Cys Leu Cys Trp Cys Cys Cys Cys Ser
          35                  40                  45            
 Cys Ser Trp Asn Gln Glu Arg Arg Arg Ala Trp Gln Ala Ser Arg Glu
      50                  55                  60                
 Ser Lys Leu Gln Pro Leu Pro Ser Cys Glu Val Cys Ala Thr Pro Ser
  65                  70                  75                  80
 Pro Glu Glu Val Gln Ser Trp Ala Gln Ser Phe Asp Lys Leu Met His
                  85                  90                  95    
 Ser Pro Ala Gly Arg Ser Val Phe Arg Ala Phe Leu Arg Thr Glu Tyr
             100                 105                 110        
 Ser Glu Glu Asn Met Leu Phe Trp Leu Ala Cys Glu Glu Leu Lys Ala
         115                 120                 125            
 Glu Ala Asn Gln His Val Val Asp Glu Lys Ala Arg Leu Ile Tyr Glu
     130                 135                 140                
 Asp Tyr Val Ser Ile Leu Ser Pro Lys Glu Val Ser Leu Asp Ser Arg
 145                 150                 155                 160
 Val Arg Glu Gly Ile Asn Lys Lys Met Gln Glu Pro Ser Ala His Thr
                 165                 170                 175    
 Phe Asp Asp Ala Gln Leu Gln Ile Tyr Thr Leu Met His Arg Asp Ser
             180                 185                 190        
 Tyr Pro Arg Phe Leu Ser Ser Pro Thr Tyr Arg Ala Leu Leu Leu Gln
         195                 200                 205            
 Gly Pro Ser Gln Ser Ser Ser Glu Ala
     210                 215        



      <210> 247
      <211> 1036
      <212> PRT
      <213> Homo sapiens


      <400> 247
 Met Val Ser Thr Leu Ile Lys His Asn Thr Ser Leu Asp Gln Pro Cys
   1               5                  10                  15    
 Val Lys Arg Trp Ser Ala Met His Glu Ala Ala Lys Gln Gly Arg Lys
              20                  25                  30        
 Asp Ile Val Ala Leu Leu Leu Lys His Gly Gly Asn Val His Leu Arg
          35                  40                  45            
 Asp Gly Phe Gly Val Thr Pro Leu Gly Val Ala Ala Glu Tyr Gly His
      50                  55                  60                
 Cys Asp Val Leu Glu His Leu Ile His Lys Gly Gly Asp Val Leu Ala
  65                  70                  75                  80
 Leu Ala Asp Asp Gly Ala Ser Val Leu Phe Glu Ala Ala Gly Gly Gly
                  85                  90                  95    
 Asn Pro Asp Cys Ile Ser Leu Leu Leu Glu Tyr Gly Gly Ser Gly Asn
             100                 105                 110        
 Val Pro Asn Arg Ala Gly His Leu Pro Ile His Arg Ala Ala Tyr Glu
         115                 120                 125            
 Gly His Tyr Leu Ala Leu Lys Tyr Leu Ile Pro Val Thr Ser Lys Asn
     130                 135                 140                
 Ala Ile Arg Lys Ser Gly Leu Thr Pro Ile His Ser Ala Ala Asp Gly
 145                 150                 155                 160
 Gln Asn Ala Gln Cys Leu Glu Leu Leu Ile Glu Asn Gly Phe Asp Val
                 165                 170                 175    
 Asn Thr Leu Leu Ala Asp His Ile Ser Gln Ser Tyr Asp Asp Glu Arg
             180                 185                 190        
 Lys Thr Ala Leu Tyr Phe Gly Val Ser Asn Asn Asp Val His Cys Thr
         195                 200                 205            
 Glu Val Leu Leu Ala Ala Gly Ala Asp Pro Asn Leu Asp Pro Leu Asn
     210                 215                 220                
 Cys Leu Leu Val Ala Val Arg Ala Asn Asn Tyr Glu Ile Val Arg Leu
 225                 230                 235                 240
 Leu Leu Ser His Gly Ala Asn Val Asn Cys Tyr Phe Met His Val Asn
                 245                 250                 255    
 Asp Thr Arg Phe Pro Ser Val Ile Gln Tyr Ala Leu Asn Asp Glu Val
             260                 265                 270        
 Met Leu Arg Leu Leu Leu Asn Asn Gly Tyr Gln Val Glu Met Cys Phe
         275                 280                 285            
 Asp Cys Met His Gly Asp Ile Phe Gly Asn Ser Phe Val Trp Ser Glu
     290                 295                 300                
 Ile Gln Glu Glu Val Leu Pro Gly Trp Thr Ser Cys Val Ile Lys Asp
 305                 310                 315                 320
 Asn Pro Asp Leu Glu Ser Ser Lys Val Thr Val Val Met Thr Leu Arg
                 325                 330                 335    
 Arg Glu Pro Tyr Gln Gly Asp Arg Cys Leu Gly Cys Ser Pro Ser Thr
             340                 345                 350        
 Ser Phe Phe Leu Ile Leu Gln Arg Thr Thr Leu Ser Lys Leu Val Arg
         355                 360                 365            
 Pro Thr Leu Gly Val Ser Gly Gln Arg Lys Gly Leu Ser Ser Glu Asp
     370                 375                 380                
 Leu Phe Glu Thr Ala Pro Ser Gly Ser Asp Lys Ala Gly Thr Met Ser
 385                 390                 395                 400
 Thr Phe Gly Tyr Arg Arg Gly Leu Ser Lys Tyr Glu Ser Ile Asp Glu
                 405                 410                 415    
 Asp Glu Leu Leu Ala Ser Leu Ser Ala Glu Glu Leu Lys Glu Leu Glu
             420                 425                 430        
 Arg Glu Leu Glu Asp Ile Glu Pro Asp Arg Asn Leu Pro Val Gly Leu
         435                 440                 445            
 Arg Gln Lys Ser Leu Thr Glu Lys Thr Pro Thr Gly Thr Phe Ser Arg
     450                 455                 460                
 Glu Ala Leu Met Ala Tyr Trp Glu Lys Glu Ser Gln Lys Leu Leu Glu
 465                 470                 475                 480
 Lys Glu Arg Leu Gly Glu Cys Gly Lys Leu Ser Val Val Ala Arg His
                 485                 490                 495    
 Asp Glu Gln Glu Leu Ala Asp Gly Gly Cys Lys Ser Asn Ser His Asn
             500                 505                 510        
 Arg Glu Asn Leu Arg Ala Ala Val Gly Trp Leu Gly Glu Gln Gly Ser
         515                 520                 525            
 Cys Val Ala Glu Asp Lys Glu Glu Ser Glu Glu Glu Leu Ile Phe Thr
     530                 535                 540                
 Glu Ser Asn Ser Glu Val Ser Glu Glu Val Tyr Thr Glu Glu Glu Glu
 545                 550                 555                 560
 Glu Glu Ser Gln Glu Glu Glu Glu Glu Glu Asp Ser Asp Glu Glu Glu
                 565                 570                 575    
 Arg Thr Ile Glu Thr Ala Lys Gly Ile Asn Gly Thr Val Asn Tyr Asp
             580                 585                 590        
 Ser Val Asn Ser Asp Asn Ser Lys Pro Lys Ile Phe Lys Ser Gln Ile
         595                 600                 605            
 Glu Asn Ile Asn Leu Thr Asn Gly Ser Asn Gly Arg Asn Thr Glu Ser
     610                 615                 620                
 Pro Ala Ala Ile His Pro Cys Gly Asn Pro Thr Val Ile Glu Asp Ala
 625                 630                 635                 640
 Leu Asp Lys Ile Lys Ser Asn Asp Pro Asp Thr Thr Glu Val Asn Leu
                 645                 650                 655    
 Asn Asn Ile Glu Asn Ile Thr Thr Gln Thr Leu Thr Arg Phe Ala Glu
             660                 665                 670        
 Ala Leu Lys Asp Asn Thr Val Val Lys Thr Phe Ser Leu Ala Asn Thr
         675                 680                 685            
 His Ala Asp Asp Ser Ala Ala Met Ala Ile Ala Glu Met Leu Lys Val
     690                 695                 700                
 Asn Glu His Ile Thr Asn Val Asn Val Glu Ser Asn Phe Ile Thr Gly
 705                 710                 715                 720
 Lys Gly Ile Leu Ala Ile Met Arg Ala Leu Gln His Asn Thr Val Leu
                 725                 730                 735    
 Thr Glu Leu Arg Phe His Asn Gln Arg His Ile Met Gly Ser Gln Val
             740                 745                 750        
 Glu Met Glu Ile Val Lys Leu Leu Lys Glu Asn Thr Thr Leu Leu Arg
         755                 760                 765            
 Leu Gly Tyr His Phe Glu Leu Pro Gly Pro Arg Met Ser Met Thr Ser
     770                 775                 780                
 Ile Leu Thr Arg Asn Met Asp Lys Gln Arg Gln Lys Arg Leu Gln Glu
 785                 790                 795                 800
 Gln Lys Gln Gln Glu Gly Tyr Asp Gly Gly Pro Asn Leu Arg Thr Lys
                 805                 810                 815    
 Val Trp Gln Arg Gly Thr Pro Ser Ser Ser Pro Tyr Val Ser Pro Arg
             820                 825                 830        
 His Ser Pro Trp Ser Ser Pro Lys Leu Pro Lys Lys Val Gln Thr Val
         835                 840                 845            
 Arg Ser Arg Pro Leu Ser Pro Val Ala Thr Pro Pro Pro Pro Pro Pro
     850                 855                 860                
 Pro Pro Pro Pro Pro Pro Pro Ser Ser Gln Arg Leu Pro Pro Pro Pro
 865                 870                 875                 880
 Pro Pro Pro Pro Pro Pro Leu Pro Glu Lys Lys Leu Ile Thr Arg Asn
                 885                 890                 895    
 Ile Ala Glu Val Ile Lys Gln Gln Glu Ser Ala Gln Arg Ala Leu Gln
             900                 905                 910        
 Asn Gly Gln Lys Lys Lys Lys Gly Lys Lys Val Lys Lys Gln Pro Asn
         915                 920                 925            
 Ser Ile Leu Lys Glu Ile Lys Asn Ser Leu Arg Ser Val Gln Glu Lys
     930                 935                 940                
 Lys Met Glu Asp Ser Ser Arg Pro Ser Thr Pro Gln Arg Ser Ala His
 945                 950                 955                 960
 Glu Asn Leu Met Glu Ala Ile Arg Gly Ser Ser Ile Lys Gln Leu Lys
                 965                 970                 975    
 Arg Met Thr Glu Val Pro Cys Asp Asp Gln Met Leu Gly Gln Cys Arg
             980                 985                 990        
 Val Thr Ala Ala Asn Glu Pro Lys Tyr Asn His Met His Gln Ser Gln
         995                1000                1005            
 Arg Leu Ala Pro Gln Asn Lys Pro Ala Phe Leu Val Arg Asp Gly His
    1010                1015                1020                
 Arg Met Leu Ala Ala Ser Ile Asn Thr Gln Met Ile
1025                1030                1035    



      <210> 248
      <211> 996
      <212> PRT
      <213> Homo sapiens


      <400> 248
 Met Val Ser Thr Leu Ile Lys His Asn Thr Ser Leu Asp Gln Pro Cys
   1               5                  10                  15    
 Val Lys Arg Trp Ser Ala Met His Glu Ala Ala Lys Gln Gly Arg Lys
              20                  25                  30        
 Asp Ile Val Ala Leu Leu Leu Lys His Gly Gly Asn Val His Leu Arg
          35                  40                  45            
 Asp Gly Phe Gly Val Thr Pro Leu Gly Val Ala Ala Glu Tyr Gly His
      50                  55                  60                
 Cys Asp Val Leu Glu His Leu Ile His Lys Gly Gly Asp Val Leu Ala
  65                  70                  75                  80
 Leu Ala Asp Asp Gly Ala Ser Val Leu Phe Glu Ala Ala Gly Gly Gly
                  85                  90                  95    
 Asn Pro Asp Cys Ile Ser Leu Leu Leu Glu Tyr Gly Gly Ser Gly Asn
             100                 105                 110        
 Val Pro Asn Arg Ala Gly His Leu Pro Ile His Arg Ala Ala Tyr Glu
         115                 120                 125            
 Gly His Tyr Leu Ala Leu Lys Tyr Leu Ile Pro Val Thr Ser Lys Asn
     130                 135                 140                
 Ala Ile Arg Lys Ser Gly Leu Thr Pro Ile His Ser Ala Ala Asp Gly
 145                 150                 155                 160
 Gln Asn Ala Gln Cys Leu Glu Leu Leu Ile Glu Asn Gly Phe Asp Val
                 165                 170                 175    
 Asn Thr Leu Leu Ala Asp His Ile Ser Gln Ser Tyr Asp Asp Glu Arg
             180                 185                 190        
 Lys Thr Ala Leu Tyr Phe Gly Val Ser Asn Asn Asp Val His Cys Thr
         195                 200                 205            
 Glu Val Leu Leu Ala Ala Gly Ala Asp Pro Asn Leu Asp Pro Leu Asn
     210                 215                 220                
 Cys Leu Leu Val Ala Val Arg Ala Asn Asn Tyr Glu Ile Val Arg Leu
 225                 230                 235                 240
 Leu Leu Ser His Gly Ala Asn Val Asn Cys Tyr Phe Met His Val Asn
                 245                 250                 255    
 Asp Thr Arg Phe Pro Ser Val Ile Gln Tyr Ala Leu Asn Asp Glu Val
             260                 265                 270        
 Met Leu Arg Leu Leu Leu Asn Asn Gly Tyr Gln Val Glu Met Cys Phe
         275                 280                 285            
 Asp Cys Met His Gly Asp Ile Phe Gly Asn Ser Phe Val Trp Ser Glu
     290                 295                 300                
 Ile Gln Glu Glu Val Leu Pro Gly Trp Thr Ser Cys Val Ile Lys Asp
 305                 310                 315                 320
 Asn Pro Asp Leu Glu Ser Ser Lys Val Thr Val Val Met Thr Leu Arg
                 325                 330                 335    
 Arg Glu Pro Tyr Gln Gly Asp Arg Cys Leu Gly Cys Ser Pro Ser Thr
             340                 345                 350        
 Ser Phe Phe Leu Ile Leu Gln Arg Thr Thr Leu Ser Lys Leu Val Arg
         355                 360                 365            
 Pro Thr Leu Gly Val Ser Gly Gln Arg Lys Gly Leu Ser Ser Glu Asp
     370                 375                 380                
 Leu Phe Glu Thr Ala Pro Ser Gly Ser Asp Lys Ala Gly Thr Met Ser
 385                 390                 395                 400
 Thr Phe Gly Tyr Arg Arg Gly Leu Ser Lys Tyr Glu Ser Ile Asp Glu
                 405                 410                 415    
 Asp Glu Leu Leu Ala Ser Leu Ser Ala Glu Glu Leu Lys Glu Leu Glu
             420                 425                 430        
 Arg Glu Leu Glu Asp Ile Glu Pro Asp Arg Asn Leu Pro Val Gly Leu
         435                 440                 445            
 Arg Gln Lys Ser Leu Thr Glu Lys Thr Pro Thr Gly Thr Phe Ser Arg
     450                 455                 460                
 Glu Ala Leu Met Ala Tyr Trp Glu Lys Glu Ser Gln Lys Leu Leu Glu
 465                 470                 475                 480
 Lys Glu Arg Leu Gly Glu Cys Gly Lys Val Ala Glu Asp Lys Glu Glu
                 485                 490                 495    
 Ser Glu Glu Glu Leu Ile Phe Thr Glu Ser Asn Ser Glu Val Ser Glu
             500                 505                 510        
 Glu Val Tyr Thr Glu Glu Glu Glu Glu Glu Ser Gln Glu Glu Glu Glu
         515                 520                 525            
 Glu Glu Asp Ser Asp Glu Glu Glu Arg Thr Ile Glu Thr Ala Lys Gly
     530                 535                 540                
 Ile Asn Gly Thr Val Asn Tyr Asp Ser Val Asn Ser Asp Asn Ser Lys
 545                 550                 555                 560
 Pro Lys Ile Phe Lys Ser Gln Ile Glu Asn Ile Asn Leu Thr Asn Gly
                 565                 570                 575    
 Ser Asn Gly Arg Asn Thr Glu Ser Pro Ala Ala Ile His Pro Cys Gly
             580                 585                 590        
 Asn Pro Thr Val Ile Glu Asp Ala Leu Asp Lys Ile Lys Ser Asn Asp
         595                 600                 605            
 Pro Asp Thr Thr Glu Val Asn Leu Asn Asn Ile Glu Asn Ile Thr Thr
     610                 615                 620                
 Gln Thr Leu Thr Arg Phe Ala Glu Ala Leu Lys Asp Asn Thr Val Val
 625                 630                 635                 640
 Lys Thr Phe Ser Leu Ala Asn Thr His Ala Asp Asp Ser Ala Ala Met
                 645                 650                 655    
 Ala Ile Ala Glu Met Leu Lys Val Asn Glu His Ile Thr Asn Val Asn
             660                 665                 670        
 Val Glu Ser Asn Phe Ile Thr Gly Lys Gly Ile Leu Ala Ile Met Arg
         675                 680                 685            
 Ala Leu Gln His Asn Thr Val Leu Thr Glu Leu Arg Phe His Asn Gln
     690                 695                 700                
 Arg His Ile Met Gly Ser Gln Val Glu Met Glu Ile Val Lys Leu Leu
 705                 710                 715                 720
 Lys Glu Asn Thr Thr Leu Leu Arg Leu Gly Tyr His Phe Glu Leu Pro
                 725                 730                 735    
 Gly Pro Arg Met Ser Met Thr Ser Ile Leu Thr Arg Asn Met Asp Lys
             740                 745                 750        
 Gln Arg Gln Lys Arg Leu Gln Glu Gln Lys Gln Gln Glu Gly Tyr Asp
         755                 760                 765            
 Gly Gly Pro Asn Leu Arg Thr Lys Val Trp Gln Arg Gly Thr Pro Ser
     770                 775                 780                
 Ser Ser Pro Tyr Val Ser Pro Arg His Ser Pro Trp Ser Ser Pro Lys
 785                 790                 795                 800
 Leu Pro Lys Lys Val Gln Thr Val Arg Ser Arg Pro Leu Ser Pro Val
                 805                 810                 815    
 Ala Thr Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ser
             820                 825                 830        
 Ser Gln Arg Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro
         835                 840                 845            
 Glu Lys Lys Leu Ile Thr Arg Asn Ile Ala Glu Val Ile Lys Gln Gln
     850                 855                 860                
 Glu Ser Ala Gln Arg Ala Leu Gln Asn Gly Gln Lys Lys Lys Lys Gly
 865                 870                 875                 880
 Lys Lys Val Lys Lys Gln Pro Asn Ser Ile Leu Lys Glu Ile Lys Asn
                 885                 890                 895    
 Ser Leu Arg Ser Val Gln Glu Lys Lys Met Glu Asp Ser Ser Arg Pro
             900                 905                 910        
 Ser Thr Pro Gln Arg Ser Ala His Glu Asn Leu Met Glu Ala Ile Arg
         915                 920                 925            
 Gly Ser Ser Ile Lys Gln Leu Lys Arg Met Thr Glu Val Pro Cys Asp
     930                 935                 940                
 Asp Gln Met Leu Gly Gln Cys Arg Val Thr Ala Ala Asn Glu Pro Lys
 945                 950                 955                 960
 Tyr Asn His Met His Gln Ser Gln Arg Leu Ala Pro Gln Asn Lys Pro
                 965                 970                 975    
 Ala Phe Leu Val Arg Asp Gly His Arg Met Leu Ala Ala Ser Ile Asn
             980                 985                 990        
 Thr Gln Met Ile
         995    



      <210> 249
      <211> 358
      <212> PRT
      <213> Homo sapiens


      <400> 249
 Met Ala Gly Cys Gly Glu Ile Asp His Ser Ile Asn Met Leu Pro Thr
   1               5                  10                  15    
 Asn Arg Lys Ala Asn Glu Ser Cys Ser Asn Thr Ala Pro Ser Leu Thr
              20                  25                  30        
 Val Pro Glu Cys Ala Ile Cys Leu Gln Thr Cys Val His Pro Val Ser
          35                  40                  45            
 Leu Pro Cys Lys His Val Phe Cys Tyr Leu Cys Val Lys Gly Ala Ser
      50                  55                  60                
 Trp Leu Gly Lys Arg Cys Ala Leu Cys Arg Gln Glu Ile Pro Glu Asp
  65                  70                  75                  80
 Phe Leu Asp Lys Pro Thr Leu Leu Ser Pro Glu Glu Leu Lys Ala Ala
                  85                  90                  95    
 Ser Arg Gly Asn Gly Glu Tyr Ala Trp Tyr Tyr Glu Gly Arg Asn Gly
             100                 105                 110        
 Trp Trp Gln Tyr Asp Glu Arg Thr Ser Arg Glu Leu Glu Asp Ala Phe
         115                 120                 125            
 Ser Lys Gly Lys Lys Asn Thr Glu Met Leu Ile Ala Gly Phe Leu Tyr
     130                 135                 140                
 Val Ala Asp Leu Glu Asn Met Val Gln Tyr Arg Arg Asn Glu His Gly
 145                 150                 155                 160
 Arg Arg Arg Lys Ile Lys Arg Asp Ile Ile Asp Ile Pro Lys Lys Gly
                 165                 170                 175    
 Val Ala Gly Leu Arg Leu Asp Cys Asp Ala Asn Thr Val Asn Leu Ala
             180                 185                 190        
 Arg Glu Ser Ser Ala Asp Gly Ala Asp Ser Val Ser Ala Gln Ser Gly
         195                 200                 205            
 Ala Ser Val Gln Pro Leu Val Ser Ser Val Arg Pro Leu Thr Ser Val
     210                 215                 220                
 Asp Gly Gln Leu Thr Ser Pro Ala Thr Pro Ser Pro Asp Ala Ser Thr
 225                 230                 235                 240
 Ser Leu Glu Asp Ser Phe Ala His Leu Gln Leu Ser Gly Asp Asn Thr
                 245                 250                 255    
 Ala Glu Arg Ser His Arg Gly Glu Gly Glu Glu Asp His Glu Ser Pro
             260                 265                 270        
 Ser Ser Gly Arg Val Pro Ala Pro Asp Thr Ser Ile Glu Glu Thr Glu
         275                 280                 285            
 Ser Asp Ala Ser Ser Asp Ser Glu Asp Val Ser Ala Val Val Ala Gln
     290                 295                 300                
 His Ser Leu Thr Gln Gln Arg Leu Leu Val Ser Asn Ala Asn Gln Thr
 305                 310                 315                 320
 Val Pro Asp Arg Ser Asp Arg Ser Gly Thr Asp Arg Ser Val Ala Gly
                 325                 330                 335    
 Gly Gly Thr Val Ser Val Ser Val Arg Ser Arg Arg Pro Asp Gly Gln
             340                 345                 350        
 Cys Thr Val Thr Glu Val
         355            



      <210> 250
      <211> 489
      <212> PRT
      <213> Homo sapiens


      <400> 250
 Met Glu Glu Ala Gly Ile Cys Gly Leu Gly Val Lys Ala Asp Met Leu
   1               5                  10                  15    
 Cys Asn Ser Gln Ser Asn Asp Ile Leu Gln His Gln Gly Ser Asn Cys
              20                  25                  30        
 Gly Gly Thr Ser Asn Lys His Ser Leu Glu Glu Asp Glu Gly Ser Asp
          35                  40                  45            
 Phe Ile Thr Glu Asn Arg Asn Leu Val Ser Pro Ala Tyr Cys Thr Gln
      50                  55                  60                
 Glu Ser Arg Glu Glu Ile Pro Gly Gly Glu Ala Arg Thr Asp Pro Pro
  65                  70                  75                  80
 Asp Gly Gln Gln Asp Ser Glu Cys Asn Arg Asn Lys Glu Lys Thr Leu
                  85                  90                  95    
 Gly Lys Glu Val Leu Leu Leu Met Gln Ala Leu Asn Thr Leu Ser Thr
             100                 105                 110        
 Pro Glu Glu Lys Leu Ala Ala Leu Cys Lys Lys Tyr Ala Asp Leu Leu
         115                 120                 125            
 Glu Glu Ser Arg Ser Val Gln Lys Gln Met Lys Ile Leu Gln Lys Lys
     130                 135                 140                
 Gln Ala Gln Ile Val Lys Glu Lys Val His Leu Gln Ser Glu His Ser
 145                 150                 155                 160
 Lys Ala Ile Leu Ala Arg Ser Lys Leu Glu Ser Leu Cys Arg Glu Leu
                 165                 170                 175    
 Gln Arg His Asn Lys Thr Leu Lys Glu Glu Asn Met Gln Gln Ala Arg
             180                 185                 190        
 Glu Glu Glu Glu Arg Arg Lys Glu Ala Thr Ala His Phe Gln Ile Thr
         195                 200                 205            
 Leu Asn Glu Ile Gln Ala Gln Leu Glu Gln His Asp Ile His Asn Ala
     210                 215                 220                
 Lys Leu Arg Gln Glu Asn Ile Glu Leu Gly Glu Lys Leu Lys Lys Leu
 225                 230                 235                 240
 Ile Glu Gln Tyr Ala Leu Arg Glu Glu His Ile Asp Lys Val Phe Lys
                 245                 250                 255    
 His Lys Glu Leu Gln Gln Gln Leu Val Asp Ala Lys Leu Gln Gln Thr
             260                 265                 270        
 Thr Gln Leu Ile Lys Glu Ala Asp Glu Lys His Gln Arg Glu Arg Glu
         275                 280                 285            
 Phe Leu Leu Lys Glu Ala Thr Glu Ser Arg His Lys Tyr Glu Gln Met
     290                 295                 300                
 Lys Gln Gln Glu Val Gln Leu Lys Gln Gln Leu Ser Leu Tyr Met Asp
 305                 310                 315                 320
 Lys Phe Glu Glu Phe Gln Thr Thr Met Ala Lys Ser Asn Glu Leu Phe
                 325                 330                 335    
 Thr Thr Phe Arg Gln Glu Met Glu Lys Met Thr Lys Lys Ile Lys Lys
             340                 345                 350        
 Leu Glu Lys Glu Thr Ile Ile Trp Arg Thr Lys Trp Glu Asn Asn Asn
         355                 360                 365            
 Lys Ala Leu Leu Gln Met Ala Glu Glu Lys Thr Val Arg Asp Lys Glu
     370                 375                 380                
 Tyr Lys Ala Leu Gln Ile Lys Leu Glu Arg Leu Glu Lys Leu Cys Arg
 385                 390                 395                 400
 Ala Leu Gln Thr Glu Arg Asn Glu Leu Asn Glu Lys Val Glu Val Leu
                 405                 410                 415    
 Lys Glu Gln Val Ser Ile Lys Ala Ala Ile Lys Ala Ala Asn Arg Asp
             420                 425                 430        
 Leu Ala Thr Pro Val Met Gln Pro Cys Thr Ala Leu Asp Ser His Lys
         435                 440                 445            
 Glu Leu Asn Thr Ser Ser Lys Arg Ala Leu Gly Ala His Leu Glu Ala
     450                 455                 460                
 Glu Pro Lys Ser Gln Arg Ser Ala Val Gln Lys Pro Pro Ser Thr Gly
 465                 470                 475                 480
 Ser Ala Pro Ala Ile Glu Ser Val Asp
                 485                



      <210> 251
      <211> 769
      <212> PRT
      <213> Homo sapiens


      <400> 251
 Met Arg Pro Val Ser Val Trp Gln Trp Ser Pro Trp Gly Leu Leu Leu
   1               5                  10                  15    
 Cys Leu Leu Cys Ser Ser Cys Leu Gly Ser Pro Ser Pro Ser Thr Gly
              20                  25                  30        
 Pro Glu Lys Lys Ala Gly Ser Gln Gly Leu Arg Phe Arg Leu Ala Gly
          35                  40                  45            
 Phe Pro Arg Lys Pro Tyr Glu Gly Arg Val Glu Ile Gln Arg Ala Gly
      50                  55                  60                
 Glu Trp Gly Thr Ile Cys Asp Asp Asp Phe Thr Leu Gln Ala Ala His
  65                  70                  75                  80
 Ile Leu Cys Arg Glu Leu Gly Phe Thr Glu Ala Thr Gly Trp Thr His
                  85                  90                  95    
 Ser Ala Lys Tyr Gly Pro Gly Thr Gly Arg Ile Trp Leu Asp Asn Leu
             100                 105                 110        
 Ser Cys Ser Gly Thr Glu Gln Ser Val Thr Glu Cys Ala Ser Arg Gly
         115                 120                 125            
 Trp Gly Asn Ser Asp Cys Thr His Asp Glu Asp Ala Gly Val Ile Cys
     130                 135                 140                
 Lys Asp Gln Arg Leu Pro Gly Phe Ser Asp Ser Asn Val Ile Glu Val
 145                 150                 155                 160
 Glu His His Leu Gln Val Glu Glu Val Arg Ile Arg Pro Ala Val Gly
                 165                 170                 175    
 Trp Gly Arg Arg Pro Leu Pro Val Thr Glu Gly Leu Val Glu Val Arg
             180                 185                 190        
 Leu Pro Asp Gly Trp Ser Gln Val Cys Asp Lys Gly Trp Ser Ala His
         195                 200                 205            
 Asn Ser His Val Val Cys Gly Met Leu Gly Phe Pro Ser Glu Lys Arg
     210                 215                 220                
 Val Asn Ala Ala Phe Tyr Arg Lys Leu Arg Lys Arg Ala Ala Lys Val
 225                 230                 235                 240
 Ser Ala Arg His Pro Lys Pro Leu Gly Arg Leu Leu Ala Gln Arg Gln
                 245                 250                 255    
 Gln His Ser Phe Gly Leu His Gly Val Ala Cys Val Gly Thr Glu Ala
             260                 265                 270        
 His Leu Ser Leu Cys Ser Leu Glu Phe Tyr Arg Ala Asn Asp Thr Ala
         275                 280                 285            
 Arg Cys Pro Gly Gly Gly Pro Ala Val Val Ser Cys Val Pro Gly Pro
     290                 295                 300                
 Val Tyr Ala Ala Ser Ser Gly Gln Lys Lys Gln Gln Gln Ser Lys Pro
 305                 310                 315                 320
 Gln Gly Glu Ala Arg Val Arg Leu Lys Gly Gly Ala His Pro Gly Glu
                 325                 330                 335    
 Gly Arg Val Glu Val Leu Lys Ala Ser Thr Trp Gly Thr Val Cys Asp
             340                 345                 350        
 Arg Lys Trp Asp Leu His Ala Ala Ser Val Val Cys Arg Glu Leu Gly
         355                 360                 365            
 Phe Gly Ser Ala Arg Glu Ala Leu Ser Gly Ala Arg Met Gly Gln Gly
     370                 375                 380                
 Met Gly Ala Ile His Leu Ser Glu Val Arg Cys Ser Gly Gln Glu Leu
 385                 390                 395                 400
 Ser Leu Trp Lys Cys Pro His Lys Asn Ile Thr Ala Glu Asp Cys Ser
                 405                 410                 415    
 His Ser Gln Asp Ala Gly Val Arg Cys Asn Leu Pro Tyr Thr Gly Ala
             420                 425                 430        
 Glu Thr Arg Ile Arg Leu Ser Gly Gly Arg Ser Gln His Glu Gly Arg
         435                 440                 445            
 Val Glu Val Gln Ile Gly Gly Pro Gly Pro Leu Arg Trp Gly Leu Ile
     450                 455                 460                
 Cys Gly Asp Asp Trp Gly Thr Leu Glu Ala Met Val Ala Cys Arg Gln
 465                 470                 475                 480
 Leu Gly Leu Gly Tyr Ala Asn His Gly Leu Gln Glu Thr Trp Tyr Trp
                 485                 490                 495    
 Asp Ser Gly Asn Ile Thr Glu Val Val Met Ser Gly Val Arg Cys Thr
             500                 505                 510        
 Gly Thr Glu Leu Ser Leu Asp Gln Cys Ala His His Gly Thr His Ile
         515                 520                 525            
 Thr Cys Lys Arg Thr Gly Thr Arg Phe Thr Ala Gly Val Ile Cys Ser
     530                 535                 540                
 Glu Thr Ala Ser Asp Leu Leu Leu His Ser Ala Leu Val Gln Glu Thr
 545                 550                 555                 560
 Ala Tyr Ile Glu Asp Arg Pro Leu His Met Leu Tyr Cys Ala Ala Glu
                 565                 570                 575    
 Glu Asn Cys Leu Ala Ser Ser Ala Arg Ser Ala Asn Trp Pro Tyr Gly
             580                 585                 590        
 His Arg Arg Leu Leu Arg Phe Ser Ser Gln Ile His Asn Leu Gly Arg
         595                 600                 605            
 Ala Asp Phe Arg Pro Lys Ala Gly Arg His Ser Trp Val Trp His Glu
     610                 615                 620                
 Cys His Gly His Tyr His Ser Met Asp Ile Phe Thr His Tyr Asp Ile
 625                 630                 635                 640
 Leu Thr Pro Asn Gly Thr Lys Val Ala Glu Gly His Lys Ala Ser Phe
                 645                 650                 655    
 Cys Leu Glu Asp Thr Glu Cys Gln Glu Asp Val Ser Lys Arg Tyr Glu
             660                 665                 670        
 Cys Ala Asn Phe Gly Glu Gln Gly Ile Thr Val Gly Cys Trp Asp Leu
         675                 680                 685            
 Tyr Arg His Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp Val Lys
     690                 695                 700                
 Pro Gly Asn Tyr Ile Leu Gln Val Val Ile Asn Pro Asn Phe Glu Val
 705                 710                 715                 720
 Ala Glu Ser Asp Phe Thr Asn Asn Ala Met Lys Cys Asn Cys Lys Tyr
                 725                 730                 735    
 Asp Gly His Arg Ile Trp Val His Asn Cys His Ile Gly Asp Ala Phe
             740                 745                 750        
 Ser Glu Glu Ala His Arg Arg Phe Glu Arg Ser Pro Gly Gln Thr Ser
         755                 760                 765            
 Thr
    



      <210> 252
      <211> 174
      <212> PRT
      <213> Homo sapiens


      <400> 252
 Met Lys Pro Pro Gly Gly Glu Ser Ser Asn Leu Phe Gly Ser Pro Glu
   1               5                  10                  15    
 Glu Ala Thr Pro Ser Ser Arg Pro Asn Arg Met Ala Ser Asn Ile Phe
              20                  25                  30        
 Gly Pro Thr Glu Glu Pro Gln Asn Ile Pro Lys Arg Thr Asn Pro Pro
          35                  40                  45            
 Gly Gly Lys Gly Ser Gly Ile Phe Asp Glu Ser Thr Pro Val Gln Thr
      50                  55                  60                
 Arg Gln His Leu Asn Pro Pro Gly Gly Lys Thr Ser Asp Ile Phe Gly
  65                  70                  75                  80
 Ser Pro Val Thr Ala Thr Ser Arg Leu Ala His Pro Asn Lys Pro Lys
                  85                  90                  95    
 Asp His Val Phe Leu Cys Glu Gly Glu Glu Pro Lys Ser Asp Leu Lys
             100                 105                 110        
 Ala Ala Arg Ser Ile Pro Ala Gly Ala Glu Pro Gly Glu Lys Gly Ser
         115                 120                 125            
 Ala Arg Lys Ala Gly Pro Ala Lys Glu Gln Glu Pro Met Pro Thr Val
     130                 135                 140                
 Asp Ser His Glu Pro Arg Leu Gly Pro Arg Ala Arg Ser His Asn Lys
 145                 150                 155                 160
 Val Leu Asn Pro Pro Gly Gly Lys Ser Ser Ile Ser Phe Tyr
                 165                 170                



      <210> 253
      <211> 131
      <212> PRT
      <213> Homo sapiens


      <400> 253
 Met Ala Pro Glu Glu Asn Ala Gly Thr Glu Leu Leu Leu Gln Ser Leu
   1               5                  10                  15    
 Glu Arg Arg Phe Leu Ala Ala Arg Ala Leu Arg Ser Leu Pro Trp Gln
              20                  25                  30        
 Ser Leu Glu Ala Lys Leu Arg Asp Ser Ser Asp Ser Glu Leu Leu Arg
          35                  40                  45            
 Asp Ile Leu Gln Lys Thr Cys Cys Ile Ala Gln Lys Pro Ser Cys Arg
      50                  55                  60                
 Trp Ser Gly Ser Cys Gly Gly Trp Leu Pro Thr Arg Ser Thr Ser Gly
  65                  70                  75                  80
 Leu Leu Lys Ser Met Trp Pro Leu Pro Ser Ala Thr Gln Arg Arg Ala
                  85                  90                  95    
 Ser Cys Ser Pro Leu Ser Tyr Ala Gly Leu Gly Ser Asp Gly Lys Trp
             100                 105                 110        
 Asn Leu Val Met Thr Arg Asn Cys Phe Pro Thr Lys Ser Thr Trp Arg
         115                 120                 125            
 Trp Gln Cys
     130    



      <210> 254
      <211> 59
      <212> PRT
      <213> Homo sapiens


      <400> 254
 Met Val Gly Gly Lys Val Gly Leu Phe Phe Asn Thr Val Arg Ser Trp
   1               5                  10                  15    
 Ala Ala Ile Lys Lys Asn Glu Phe Met Ser Phe Ala Gly Thr Trp Leu
              20                  25                  30        
 Lys Leu Glu Ala Ile Ile Leu Ser Lys Leu Ile Gln Glu Glu Lys Thr
          35                  40                  45            
 Lys His His Met Phe Ser Leu Ile Ser Gly Ser
      50                  55                



      <210> 255
      <211> 325
      <212> PRT
      <213> Homo sapiens


      <400> 255
 Met Ala Thr Pro Leu Pro Pro Pro Ser Pro Arg His Leu Arg Leu Leu
   1               5                  10                  15    
 Arg Leu Leu Leu Ser Gly Leu Val Leu Gly Ala Ala Leu Arg Gly Ala
              20                  25                  30        
 Ala Ala Gly His Pro Asp Val Ala Ala Cys Pro Gly Ser Leu Asp Cys
          35                  40                  45            
 Ala Leu Lys Arg Arg Ala Arg Cys Pro Pro Gly Ala His Ala Cys Gly
      50                  55                  60                
 Pro Cys Leu Gln Pro Phe Gln Glu Asp Gln Gln Gly Leu Cys Val Pro
  65                  70                  75                  80
 Arg Met Arg Arg Pro Pro Gly Gly Gly Arg Pro Gln Pro Arg Leu Glu
                  85                  90                  95    
 Asp Glu Ile Asp Phe Leu Ala Gln Glu Leu Ala Arg Lys Glu Ser Gly
             100                 105                 110        
 His Ser Thr Pro Pro Leu Pro Lys Asp Arg Gln Arg Leu Pro Glu Pro
         115                 120                 125            
 Ala Thr Leu Gly Phe Ser Ala Arg Gly Gln Gly Leu Glu Leu Gly Leu
     130                 135                 140                
 Pro Ser Thr Pro Gly Thr Pro Thr Pro Thr Pro His Thr Ser Leu Gly
 145                 150                 155                 160
 Ser Pro Val Ser Ser Asp Pro Val His Met Ser Pro Leu Glu Pro Arg
                 165                 170                 175    
 Gly Gly Gln Gly Asp Gly Leu Ala Leu Val Leu Ile Leu Ala Phe Cys
             180                 185                 190        
 Val Ala Gly Ala Ala Ala Leu Ser Val Ala Ser Leu Cys Trp Cys Arg
         195                 200                 205            
 Leu Gln Arg Glu Ile Arg Leu Thr Gln Lys Ala Asp Tyr Ala Thr Ala
     210                 215                 220                
 Lys Ala Pro Gly Ser Pro Ala Ala Pro Arg Ile Ser Pro Gly Asp Gln
 225                 230                 235                 240
 Arg Leu Ala Gln Ser Ala Glu Met Tyr His Tyr Gln His Gln Arg Gln
                 245                 250                 255    
 Gln Met Leu Cys Leu Glu Arg His Lys Glu Pro Pro Lys Glu Leu Asp
             260                 265                 270        
 Thr Ala Ser Ser Asp Glu Glu Asn Glu Asp Gly Asp Phe Thr Val Tyr
         275                 280                 285            
 Glu Cys Pro Gly Leu Ala Pro Thr Gly Glu Met Glu Val Arg Asn Pro
     290                 295                 300                
 Leu Phe Asp His Ala Ala Leu Ser Ala Pro Leu Pro Ala Pro Ser Ser
 305                 310                 315                 320
 Pro Pro Ala Leu Pro
                 325



      <210> 256
      <211> 1372
      <212> PRT
      <213> Homo sapiens


      <400> 256
 Met Asp Glu Ser Thr Phe Ala Gly Gly Gln Glu Tyr Gly Gly Trp Val
   1               5                  10                  15    
 Pro Glu His His Lys Ser Asn Glu Pro Lys Ser Gly His Ile Glu Lys
              20                  25                  30        
 Gly Asn Thr Asp Gln Cys Gln Glu Arg Thr Pro Gln Pro Met Ile Tyr
          35                  40                  45            
 Pro Thr Gly Glu Ile Glu Ser Thr Val Asn Ala Trp Met Leu Ser His
      50                  55                  60                
 Glu Lys Glu Gln Ser Gln Ile Leu Leu Ile Ser Asn Cys Leu Asp Ala
  65                  70                  75                  80
 Leu Lys His Arg Ser Cys Asp Tyr Gly Leu Lys Ile Ala Leu Asp Ile
                  85                  90                  95    
 Lys His Arg Leu Lys Ile Gln Pro Lys Ile Phe Ile Tyr Thr Arg Thr
             100                 105                 110        
 His Lys Tyr Ala Val Thr Leu His Met Leu Ala His Thr Ile Thr Ser
         115                 120                 125            
 Glu Arg Asp Asp Ile Glu Glu Trp Leu Asn Ala Trp Val Val Asp Gln
     130                 135                 140                
 Cys Cys Pro Pro Glu Met Ser Val Met Met Glu Met Phe Tyr Ile Tyr
 145                 150                 155                 160
 Ala Val His Tyr Gly Arg Ser Leu Leu Ser Trp Ser Gln Glu Glu Glu
                 165                 170                 175    
 Lys Glu Lys Gly Gly Arg Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
             180                 185                 190        
 Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
         195                 200                 205            
 Glu Ala Glu Glu Glu Lys Leu Gly Glu Ala Ala Val Pro Glu Gly Val
     210                 215                 220                
 Gln Leu Gly Trp Leu Thr Ala Leu Ser Leu Val Val Asn Phe His Pro
 225                 230                 235                 240
 Val Val Leu Val Ser Pro Trp Thr Trp Tyr Arg Pro Cys Ala Ile Leu
                 245                 250                 255    
 Ile Ser Leu Asp Arg Ala Arg Ala Ala Ala Gln Gly Gly Ser Arg Lys
             260                 265                 270        
 Gly Trp Ala Glu Phe Gln Ala Arg Gly Thr Glu Arg Arg Glu Gln Cys
         275                 280                 285            
 Ser Ala Ala Leu Val Arg Glu Met Glu Gln Arg Leu Leu Cys Gly Leu
     290                 295                 300                
 Leu His Pro Arg Pro Gly Cys Thr Ala Arg Ile Phe Asp Leu Ser Val
 305                 310                 315                 320
 Ala Arg Trp Leu Ala Ala Arg Trp Gly Ser Ala Cys Pro Gly Gly Ala
                 325                 330                 335    
 Ala Arg Ala Pro Arg Gly Ala Leu Ala Pro Gly Leu Arg Gln Ser Glu
             340                 345                 350        
 Ala Val Pro Ala Pro Leu Pro Pro Arg Val Ala Asp Ala Ala Gly Ala
         355                 360                 365            
 Ser Gly Lys Arg Ser Gly Arg Arg Ala Arg Ser Cys Pro Ser Pro Met
     370                 375                 380                
 Ala Arg Ala Ala Arg Val Ala Val Ala Ala Val Gly Pro His Ala Gly
 385                 390                 395                 400
 His Arg Thr Arg Arg Leu Ala Gly Arg Gly Arg Glu Gly Arg Ala Ala
                 405                 410                 415    
 Leu Ala Ala Gly Ala Gln Leu Pro Ala Ile Gly Asp Ala Arg Arg His
             420                 425                 430        
 Leu Val Ser Arg Lys Arg Pro Ser Glu Met Gly Phe Asp Pro Ala Cys
         435                 440                 445            
 Gly Arg Arg Val Phe Arg Arg Arg Gly Cys Gly Gln Ala Val Pro Pro
     450                 455                 460                
 Leu Trp Phe Pro Gly Leu Leu Leu Ala Pro Ser Trp Pro Asp Gly Arg
 465                 470                 475                 480
 Pro Gly Arg Arg Ala His Leu Lys Phe Ala Leu Leu Tyr Gly Glu Gly
                 485                 490                 495    
 Lys Phe Glu Ser Pro Glu Gly Lys Tyr Phe Ala Lys Arg Gln Ala Arg
             500                 505                 510        
 Ile Arg Gly Trp Thr Gln Glu Asp Pro Glu Ala Ser Gly Thr Ser Ser
         515                 520                 525            
 Asn Arg Ala Arg Ser Glu Pro Ser Val Leu Thr Val Ala Gly Ile Leu
     530                 535                 540                
 Gln Thr Glu Ser Arg Lys Thr Ala Lys Asp Ile Cys Lys Ile Arg Cys
 545                 550                 555                 560
 Leu Cys Glu Glu Lys Glu Asn Val Leu Asn Ile Asn Cys Glu Asn Lys
                 565                 570                 575    
 Gly Phe Thr Thr Val Ser Leu Leu Gln Pro Pro Gln Tyr Arg Ile Tyr
             580                 585                 590        
 Gln Leu Phe Leu Asn Gly Asn Leu Leu Thr Arg Leu Tyr Pro Asn Glu
         595                 600                 605            
 Phe Val Asn Tyr Ser Asn Ala Val Thr Leu His Leu Gly Asn Asn Gly
     610                 615                 620                
 Leu Gln Glu Ile Arg Thr Gly Ala Phe Ser Gly Leu Lys Thr Leu Lys
 625                 630                 635                 640
 Arg Leu His Leu Asn Asn Asn Lys Leu Glu Ile Leu Arg Glu Asp Thr
                 645                 650                 655    
 Phe Leu Gly Leu Glu Ser Leu Glu Tyr Leu Gln Ala Asp Tyr Asn Tyr
             660                 665                 670        
 Ile Ser Ala Ile Glu Ala Gly Ala Phe Ser Lys Leu Asn Lys Leu Lys
         675                 680                 685            
 Val Leu Ile Leu Asn Asp Asn Leu Leu Leu Ser Leu Pro Ser Asn Val
     690                 695                 700                
 Phe Arg Phe Val Leu Leu Thr His Leu Asp Leu Arg Gly Asn Arg Leu
 705                 710                 715                 720
 Lys Val Met Pro Phe Ala Gly Val Leu Glu His Ile Gly Gly Ile Met
                 725                 730                 735    
 Glu Ile Gln Leu Glu Glu Asn Pro Trp Asn Cys Thr Cys Asp Leu Leu
             740                 745                 750        
 Pro Leu Lys Ala Trp Leu Asp Thr Ile Thr Val Phe Val Gly Glu Ile
         755                 760                 765            
 Val Cys Glu Thr Pro Phe Arg Leu His Gly Lys Asp Val Thr Gln Leu
     770                 775                 780                
 Thr Arg Gln Asp Leu Cys Pro Arg Lys Ser Ala Ser Asp Ser Ser Gln
 785                 790                 795                 800
 Arg Gly Ser His Ala Asp Thr His Val Gln Arg Leu Ser Pro Thr Met
                 805                 810                 815    
 Asn Pro Ala Leu Asn Pro Thr Arg Ala Pro Lys Ala Ser Arg Pro Pro
             820                 825                 830        
 Lys Met Arg Asn Arg Pro Thr Pro Arg Val Thr Val Ser Lys Asp Arg
         835                 840                 845            
 Gln Ser Phe Gly Pro Ile Met Val Tyr Gln Thr Lys Ser Pro Val Pro
     850                 855                 860                
 Leu Thr Cys Pro Ser Ser Cys Val Cys Thr Ser Gln Ser Ser Asp Asn
 865                 870                 875                 880
 Gly Leu Asn Val Asn Cys Gln Glu Arg Lys Phe Thr Asn Ile Ser Asp
                 885                 890                 895    
 Leu Gln Pro Lys Pro Thr Ser Pro Lys Lys Leu Tyr Leu Thr Gly Asn
             900                 905                 910        
 Tyr Leu Gln Thr Val Tyr Lys Asn Asp Leu Leu Glu Tyr Ser Ser Leu
         915                 920                 925            
 Asp Leu Leu His Leu Gly Asn Asn Arg Ile Ala Val Ile Gln Glu Gly
     930                 935                 940                
 Ala Phe Thr Asn Leu Thr Ser Leu Arg Arg Leu Tyr Leu Asn Gly Asn
 945                 950                 955                 960
 Tyr Leu Glu Val Leu Tyr Pro Ser Met Phe Asp Gly Leu Gln Ser Leu
                 965                 970                 975    
 Gln Tyr Leu Tyr Leu Glu Tyr Asn Val Ile Lys Glu Ile Lys Pro Leu
             980                 985                 990        
 Thr Phe Asp Ala Leu Ile Asn Leu Gln Leu Leu Phe Leu Asn Asn Asn
         995                1000                1005            
 Leu Leu Arg Ser Leu Pro Asp Asn Ile Phe Gly Gly Thr Ala Leu Thr
    1010                1015                1020                
 Arg Leu Asn Leu Arg Asn Asn His Phe Ser His Leu Pro Val Lys Gly
1025                1030                1035                1040
 Val Leu Asp Gln Leu Pro Ala Phe Ile Gln Ile Asp Leu Gln Glu Asn
                1045                1050                1055    
 Pro Trp Asp Cys Thr Cys Asp Ile Met Gly Leu Lys Asp Trp Thr Glu
            1060                1065                1070        
 His Ala Asn Ser Pro Val Ile Ile Asn Glu Val Thr Cys Glu Ser Pro
        1075                1080                1085            
 Ala Lys His Ala Gly Glu Ile Leu Lys Phe Leu Gly Arg Glu Ala Ile
    1090                1095                1100                
 Cys Pro Asp Ser Pro Asn Leu Ser Asp Gly Thr Val Leu Ser Met Asn
1105                1110                1115                1120
 His Asn Thr Asp Thr Pro Arg Ser Leu Ser Val Ser Pro Ser Ser Tyr
                1125                1130                1135    
 Pro Glu Leu His Thr Glu Val Pro Leu Ser Val Leu Ile Leu Gly Leu
            1140                1145                1150        
 Leu Val Val Phe Ile Leu Ser Val Cys Phe Gly Ala Gly Leu Phe Val
        1155                1160                1165            
 Phe Val Leu Lys Arg Arg Lys Gly Val Pro Ser Val Pro Arg Asn Thr
    1170                1175                1180                
 Asn Asn Leu Asp Val Ser Ser Phe Gln Leu Gln Tyr Gly Ser Tyr Asn
1185                1190                1195                1200
 Thr Glu Thr His Asp Lys Thr Asp Gly His Val Tyr Asn Tyr Ile Pro
                1205                1210                1215    
 Pro Pro Val Gly Gln Met Cys Gln Asn Pro Ile Tyr Met Gln Lys Glu
            1220                1225                1230        
 Gly Asp Pro Val Ala Tyr Tyr Arg Asn Leu Gln Glu Phe Ser Tyr Ser
        1235                1240                1245            
 Asn Leu Glu Glu Lys Lys Glu Glu Pro Ala Thr Pro Ala Tyr Thr Ile
    1250                1255                1260                
 Ser Ala Thr Glu Leu Leu Glu Lys Gln Ala Thr Pro Arg Glu Pro Glu
1265                1270                1275                1280
 Leu Leu Tyr Gln Asn Ile Ala Glu Arg Val Lys Glu Leu Pro Ser Ala
                1285                1290                1295    
 Gly Leu Val His Tyr Asn Phe Cys Thr Leu Pro Lys Arg Gln Phe Ala
            1300                1305                1310        
 Pro Ser Tyr Glu Ser Arg Arg Gln Asn Gln Asp Arg Ile Asn Lys Thr
        1315                1320                1325            
 Val Leu Tyr Gly Thr Pro Arg Lys Cys Phe Val Gly Gln Ser Lys Pro
    1330                1335                1340                
 Asn His Pro Leu Leu Gln Ala Lys Pro Gln Ser Glu Pro Asp Tyr Leu
1345                1350                1355                1360
 Glu Val Leu Glu Lys Gln Thr Ala Ile Ser Gln Leu
                1365                1370        



      <210> 257
      <211> 131
      <212> PRT
      <213> Homo sapiens


      <400> 257
 Met Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly
   1               5                  10                  15    
 Lys Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg
              20                  25                  30        
 Met Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp
          35                  40                  45            
 Leu Ser His Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys Val Ala
      50                  55                  60                
 Asp Met Pro Asn Ala Leu Ser Ala Leu Ser Asp Leu His Ala His Lys
  65                  70                  75                  80
 Leu Arg Val Asp Pro Val Asn Phe Lys Leu Leu Ser His Cys Leu Leu
                  85                  90                  95    
 Val Thr Leu Ala Ala His Leu Pro Ala Glu Phe Thr Pro Ala Val His
             100                 105                 110        
 Ala Ser Leu Asp Lys Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser
         115                 120                 125            
 Lys Tyr Arg
     130    



      <210> 258
      <211> 406
      <212> PRT
      <213> Homo sapiens


      <400> 258
 Met His Pro Ala Val Phe Leu Ser Leu Pro Asp Leu Arg Cys Ser Leu
   1               5                  10                  15    
 Leu Leu Leu Val Thr Trp Val Phe Thr Pro Val Thr Thr Glu Ile Thr
              20                  25                  30        
 Ser Leu Asp Thr Glu Asn Ile Asp Glu Ile Leu Asn Asn Ala Asp Val
          35                  40                  45            
 Ala Leu Val Asn Phe Tyr Ala Asp Trp Cys Arg Phe Ser Gln Met Leu
      50                  55                  60                
 His Pro Ile Phe Glu Glu Ala Ser Asp Val Ile Lys Glu Glu Phe Pro
  65                  70                  75                  80
 Asn Glu Asn Gln Val Val Phe Ala Arg Val Asp Cys Asp Gln His Ser
                  85                  90                  95    
 Asp Ile Ala Gln Arg Tyr Arg Ile Ser Lys Tyr Pro Thr Leu Lys Leu
             100                 105                 110        
 Phe Arg Asn Gly Met Met Met Lys Arg Glu Tyr Arg Gly Gln Arg Ser
         115                 120                 125            
 Val Lys Ala Leu Ala Asp Tyr Ile Arg Gln Gln Lys Ser Asp Pro Ile
     130                 135                 140                
 Gln Glu Ile Arg Asp Leu Ala Glu Ile Thr Thr Leu Asp Arg Ser Lys
 145                 150                 155                 160
 Arg Asn Ile Ile Gly Tyr Phe Glu Gln Lys Asp Ser Asp Asn Tyr Arg
                 165                 170                 175    
 Val Phe Glu Arg Val Ala Asn Ile Leu His Asp Asp Cys Ala Phe Leu
             180                 185                 190        
 Ser Ala Phe Gly Asp Val Ser Lys Pro Glu Arg Tyr Ser Gly Asp Asn
         195                 200                 205            
 Ile Ile Tyr Lys Pro Pro Gly His Ser Ala Pro Asp Met Val Tyr Leu
     210                 215                 220                
 Gly Ala Met Thr Asn Phe Asp Val Thr Tyr Asn Trp Ile Gln Asp Lys
 225                 230                 235                 240
 Cys Val Pro Leu Val Arg Glu Ile Thr Phe Glu Asn Gly Glu Glu Leu
                 245                 250                 255    
 Thr Glu Glu Gly Leu Pro Phe Leu Ile Leu Phe His Met Lys Glu Asp
             260                 265                 270        
 Thr Glu Ser Leu Glu Ile Phe Gln Asn Glu Val Ala Arg Gln Leu Ile
         275                 280                 285            
 Ser Glu Lys Gly Thr Ile Asn Phe Leu His Ala Asp Cys Asp Lys Phe
     290                 295                 300                
 Arg His Pro Leu Leu His Ile Gln Lys Thr Pro Ala Asp Cys Pro Val
 305                 310                 315                 320
 Ile Ala Ile Asp Ser Phe Arg His Met Tyr Val Phe Gly Asp Phe Lys
                 325                 330                 335    
 Asp Val Leu Ile Pro Gly Lys Leu Lys Gln Phe Val Phe Asp Leu His
             340                 345                 350        
 Ser Gly Lys Leu His Arg Glu Phe His His Gly Pro Asp Pro Thr Asp
         355                 360                 365            
 Thr Ala Pro Gly Glu Gln Ala Gln Asp Val Ala Ser Ser Pro Pro Glu
     370                 375                 380                
 Ser Ser Phe Gln Lys Leu Ala Pro Ser Glu Tyr Arg Tyr Thr Leu Leu
 385                 390                 395                 400
 Arg Asp Arg Asp Glu Leu
                 405    



      <210> 259
      <211> 246
      <212> PRT
      <213> Homo sapiens


      <400> 259
 Met Ser Arg Gly Ser Ser Ala Gly Phe Asp Arg His Ile Thr Ile Phe
   1               5                  10                  15    
 Ser Pro Glu Gly Arg Leu Tyr Gln Val Glu Tyr Ala Phe Lys Ala Ile
              20                  25                  30        
 Asn Gln Gly Gly Leu Thr Ser Val Ala Val Arg Gly Lys Asp Cys Ala
          35                  40                  45            
 Val Ile Val Thr Gln Lys Lys Val Pro Asp Lys Leu Leu Asp Ser Ser
      50                  55                  60                
 Thr Val Thr His Leu Phe Lys Ile Thr Glu Asn Ile Gly Cys Val Met
  65                  70                  75                  80
 Thr Gly Met Thr Ala Asp Ser Arg Ser Gln Val Gln Arg Ala Arg Tyr
                  85                  90                  95    
 Glu Ala Ala Asn Trp Lys Tyr Lys Tyr Gly Tyr Glu Ile Pro Val Asp
             100                 105                 110        
 Met Leu Cys Lys Arg Ile Ala Asp Ile Ser Gln Val Tyr Thr Gln Asn
         115                 120                 125            
 Ala Glu Met Arg Pro Leu Gly Cys Cys Met Ile Leu Ile Gly Ile Asp
     130                 135                 140                
 Glu Glu Gln Gly Pro Gln Val Tyr Lys Cys Asp Pro Ala Gly Tyr Tyr
 145                 150                 155                 160
 Cys Gly Phe Lys Ala Thr Ala Ala Gly Val Lys Gln Thr Glu Ser Thr
                 165                 170                 175    
 Ser Phe Leu Glu Lys Lys Val Lys Lys Lys Phe Asp Trp Thr Phe Glu
             180                 185                 190        
 Gln Thr Val Glu Thr Ala Ile Thr Cys Leu Ser Thr Val Leu Ser Ile
         195                 200                 205            
 Asp Phe Lys Pro Ser Glu Ile Glu Val Gly Val Val Thr Val Glu Asn
     210                 215                 220                
 Pro Lys Phe Arg Ile Leu Thr Glu Ala Glu Ile Asp Ala His Leu Val
 225                 230                 235                 240
 Ala Leu Ala Glu Arg Asp
                 245    



      <210> 260
      <211> 611
      <212> PRT
      <213> Homo sapiens


      <400> 260
 Met Asn Asp Ile Ser Gln Lys Ala Glu Ile Lys Glu Met Leu Ala Ser
   1               5                  10                  15    
 Asp Asp Glu Glu Asp Val Ser Ser Lys Val Glu Lys Ala Tyr Val Pro
              20                  25                  30        
 Lys Leu Thr Gly Thr Val Lys Gly Arg Phe Ala Glu Met Glu Lys Gln
          35                  40                  45            
 Arg Gln Glu Glu Gln Arg Lys Arg Thr Glu Glu Glu Arg Lys Arg Arg
      50                  55                  60                
 Ile Glu Gln Asp Met Leu Glu Lys Arg Lys Ile Gln Arg Glu Leu Ala
  65                  70                  75                  80
 Lys Arg Ala Glu Gln Ile Glu Asp Lys Asn Asn Thr Gly Thr Glu Ser
                  85                  90                  95    
 Ala Ser Glu Glu Gly Asp Asp Ser Leu Leu Ile Thr Val Val Pro Val
             100                 105                 110        
 Lys Ser Tyr Lys Thr Ser Gly Lys Met Lys Lys Asn Phe Glu Asp Leu
         115                 120                 125            
 Glu Lys Glu Arg Glu Glu Lys Glu Arg Ile Lys Tyr Glu Glu Asp Lys
     130                 135                 140                
 Arg Ile Arg Tyr Glu Glu Gln Arg Pro Ser Leu Lys Glu Ala Lys Cys
 145                 150                 155                 160
 Leu Ser Leu Val Met Asp Asp Glu Ile Glu Ser Glu Ala Lys Lys Glu
                 165                 170                 175    
 Ser Leu Ser Pro Gly Lys Leu Lys Leu Thr Phe Glu Glu Leu Glu Arg
             180                 185                 190        
 Gln Arg Gln Glu Asn Arg Lys Lys Gln Ala Glu Glu Glu Ala Arg Lys
         195                 200                 205            
 Arg Leu Glu Glu Glu Lys Arg Ala Phe Glu Glu Ala Arg Arg Gln Met
     210                 215                 220                
 Val Asn Glu Asp Glu Glu Asn Gln Asp Thr Ala Lys Ile Phe Lys Gly
 225                 230                 235                 240
 Tyr Arg Pro Gly Lys Leu Lys Leu Ser Phe Glu Glu Met Glu Arg Gln
                 245                 250                 255    
 Arg Arg Glu Asp Glu Lys Arg Lys Ala Glu Glu Glu Ala Arg Arg Arg
             260                 265                 270        
 Ile Glu Glu Glu Lys Lys Ala Phe Ala Glu Ala Arg Arg Asn Met Val
         275                 280                 285            
 Val Asp Asp Asp Ser Pro Glu Met Tyr Lys Thr Ile Ser Gln Glu Phe
     290                 295                 300                
 Leu Thr Pro Gly Lys Leu Glu Ile Asn Phe Glu Glu Leu Leu Lys Gln
 305                 310                 315                 320
 Lys Met Glu Glu Glu Lys Arg Arg Thr Glu Glu Glu Arg Lys His Lys
                 325                 330                 335    
 Leu Glu Met Glu Lys Gln Glu Phe Glu Gln Leu Arg Gln Glu Met Gly
             340                 345                 350        
 Glu Glu Glu Glu Glu Asn Glu Thr Phe Gly Leu Ser Arg Glu Tyr Glu
         355                 360                 365            
 Glu Leu Ile Lys Leu Lys Arg Ser Gly Ser Ile Gln Ala Lys Asn Leu
     370                 375                 380                
 Lys Ser Lys Phe Glu Lys Ile Gly Gln Leu Ser Glu Lys Glu Ile Gln
 385                 390                 395                 400
 Lys Lys Ile Glu Glu Glu Arg Ala Arg Arg Arg Ala Ile Asp Leu Glu
                 405                 410                 415    
 Ile Lys Glu Arg Glu Ala Glu Asn Phe His Glu Glu Asp Asp Val Asp
             420                 425                 430        
 Val Arg Pro Ala Arg Lys Ser Glu Ala Pro Phe Thr His Lys Val Asn
         435                 440                 445            
 Met Lys Ala Arg Phe Glu Gln Met Ala Lys Ala Arg Glu Glu Glu Glu
     450                 455                 460                
 Gln Arg Arg Ile Glu Glu Gln Lys Leu Leu Arg Met Gln Phe Glu Gln
 465                 470                 475                 480
 Arg Glu Ile Asp Ala Ala Leu Gln Lys Lys Arg Glu Glu Glu Glu Glu
                 485                 490                 495    
 Glu Glu Gly Ser Ile Met Asn Gly Ser Thr Ala Glu Asp Glu Glu Gln
             500                 505                 510        
 Thr Arg Ser Gly Ala Pro Trp Phe Lys Lys Pro Leu Lys Asn Thr Ser
         515                 520                 525            
 Val Val Asp Ser Glu Pro Val Arg Phe Thr Val Lys Val Thr Gly Glu
     530                 535                 540                
 Pro Lys Pro Glu Ile Thr Trp Trp Phe Glu Gly Glu Ile Leu Gln Asp
 545                 550                 555                 560
 Gly Glu Asp Tyr Gln Tyr Ile Glu Arg Gly Glu Thr Tyr Cys Leu Tyr
                 565                 570                 575    
 Leu Pro Glu Thr Phe Pro Glu Asp Gly Gly Glu Tyr Met Cys Lys Ala
             580                 585                 590        
 Val Asn Asn Lys Gly Ser Ala Ala Ser Thr Cys Ile Leu Thr Ile Glu
         595                 600                 605            
 Ser Lys Asn
     610    



      <210> 261
      <211> 64
      <212> PRT
      <213> Homo sapiens


      <400> 261
 Met Glu Phe His Ser Ser Pro Arg Leu Glu Cys Ser Gly Thr Ile Ser
   1               5                  10                  15    
 Ala His Cys Asp Leu His Leu Leu Gly Ser Ser Asp Ser Pro Ala Ser
              20                  25                  30        
 Thr Ser Arg Val Val Gly Thr Thr Gly Val Cys His His Ala Trp Thr
          35                  40                  45            
 Val Leu Gly Phe Phe Cys Ile Phe Ser Gly Asp Arg Val Leu Pro Ser
      50                  55                  60                





      <210> 262
      <211> 307
      <212> PRT
      <213> Homo sapiens


      <400> 262
 Met Ser Leu Ala Ala Pro Asp Ala Asn Pro Val Val Gly Phe Leu Ala
   1               5                  10                  15    
 Tyr Ser Arg Pro Ser Val Leu Pro Gly Trp His Arg Pro His Arg Thr
              20                  25                  30        
 Ser Arg Val Gly Leu Ser Gly Ser Ser Thr Ala Gly Pro Arg Asn Ser
          35                  40                  45            
 Arg Phe Gly Ala Ala Pro Ser Arg Leu Gly His Thr Gly Ala Arg Cys
      50                  55                  60                
 Arg Ser Pro Val Leu Arg His Leu Val Trp Asn Phe Arg Leu Ala Val
  65                  70                  75                  80
 Ser Ser Arg Ser Gly Ala Leu Met Lys Thr Ile Leu Ser Asn Gln Thr
                  85                  90                  95    
 Val Asp Ile Pro Glu Asn Gly Met Arg Leu Asp Val Phe Tyr Leu His
             100                 105                 110        
 Leu Tyr Cys Thr Phe Gln Ala Leu Cys Gly Leu Thr Ser Val Phe Ser
         115                 120                 125            
 Leu Leu Val Asp Ile Thr Leu Lys Gly Arg Thr Val Ile Val Lys Gly
     130                 135                 140                
 Pro Arg Gly Thr Leu Arg Arg Asp Phe Asn His Ile Asn Val Glu Leu
 145                 150                 155                 160
 Ser Leu Leu Gly Lys Lys Lys Lys Arg Leu Arg Val Asp Lys Trp Trp
                 165                 170                 175    
 Gly Asn Arg Lys Glu Leu Ala Thr Val Arg Thr Ile Cys Ser His Val
             180                 185                 190        
 Gln Asn Met Ile Lys Gly Val Thr Leu Gly Phe Arg Tyr Lys Met Arg
         195                 200                 205            
 Ser Val Tyr Ala His Phe Pro Ile Asn Val Val Ile Gln Glu Asn Gly
     210                 215                 220                
 Ser Leu Val Glu Ile Arg Asn Phe Leu Gly Glu Lys Tyr Ile Arg Arg
 225                 230                 235                 240
 Val Arg Met Arg Pro Gly Val Ala Cys Ser Val Ser Gln Ala Gln Lys
                 245                 250                 255    
 Asp Glu Leu Ile Leu Glu Gly Asn Asp Ile Glu Leu Val Ser Asn Ser
             260                 265                 270        
 Ala Ala Leu Ile Gln Gln Ala Thr Thr Val Lys Asn Lys Asp Ile Arg
         275                 280                 285            
 Lys Phe Leu Asp Gly Ile Tyr Val Ser Glu Lys Gly Thr Val Gln Gln
     290                 295                 300                
 Ala Asp Glu
 305        



      <210> 263
      <211> 219
      <212> PRT
      <213> Homo sapiens


      <400> 263
 Met Asp Ile Ile Val Leu Leu Pro Lys Gly His Cys Thr Lys Ile Gln
   1               5                  10                  15    
 Glu Leu Gln Met Thr Thr Val Leu Lys Gln Asn Val His Val Phe Gly
              20                  25                  30        
 Val Glu Gly Asn Ser Asp Glu Leu Asp Glu Pro Ile Lys Thr Val Phe
          35                  40                  45            
 Ala Asp Val Ala Phe Val Lys Lys His Asn Leu Met Ser Leu Asn Ser
      50                  55                  60                
 Ile Asn Trp Ser Arg Val Leu Val Gln Met Ala His His Phe Phe Ala
  65                  70                  75                  80
 Tyr Phe Gln Cys Thr Pro Ser Leu Asp Thr His Pro Leu Pro Leu Val
                  85                  90                  95    
 Glu Val Val Val Pro Thr Gly Ala Ala Gly Asn Leu Ala Ala Gly Tyr
             100                 105                 110        
 Ile Ala Gln Lys Ile Gly Leu Pro Ile Arg Leu Val Val Ala Val Asn
         115                 120                 125            
 Arg Asn Asp Ile Ile His Arg Thr Val Gln Gln Gly Asp Phe Ser Leu
     130                 135                 140                
 Ser Glu Ala Val Lys Ser Thr Leu Ala Ser Ala Met Asp Ile Gln Val
 145                 150                 155                 160
 Pro Tyr Asn Met Glu Arg Val Phe Trp Leu Leu Ser Gly Ser Asp Ser
                 165                 170                 175    
 Gln Val Thr Arg Ala Leu Met Glu Gln Phe Glu Arg Thr Gln Ser Val
             180                 185                 190        
 Asn Leu Pro Lys Glu Leu His Ser Lys Gly Pro Ser Ser Ser Pro Ser
         195                 200                 205            
 Ser Gly Arg Asp Arg Thr Thr Lys Lys Trp Leu
     210                 215                



      <210> 264
      <211> 473
      <212> PRT
      <213> Homo sapiens


      <400> 264
 Met Arg Ala Val Ser Leu Leu Val Leu Val Leu Gly Val Thr Met Ser
   1               5                  10                  15    
 Tyr Val Met Pro Trp Pro Gln Thr Glu Asn Tyr Thr Ile Tyr Phe Pro
              20                  25                  30        
 Gly Ser Glu Ala Phe Lys Leu Gly Arg Ala Ile Ser Ser Leu Pro Ser
          35                  40                  45            
 Ile Gln Tyr Pro Gly Ser Ser Ala Tyr Arg Trp Pro Val Met Glu Leu
      50                  55                  60                
 Leu Ser Leu Tyr Asn Tyr Ala Arg Arg Ala Leu Met Gly Asn Leu Ala
  65                  70                  75                  80
 Asn Val Ile Pro Trp Gly Trp Ser Glu Lys Met Thr Ile Glu Tyr Leu
                  85                  90                  95    
 Asn Pro Gly Thr Gly Glu Leu Leu Asn Asn Ser Arg Gly Asp Ala Pro
             100                 105                 110        
 His Ser Glu His Val His His Arg Arg Val Pro Arg Ala Gly Asn Ala
         115                 120                 125            
 Ala Ala Ser Asp Cys Cys Val Gly Ala Ala Ala Pro Pro Gly Gln Asp
     130                 135                 140                
 Arg Arg Gly Gly Ala Ser Gly Val Gly Lys Thr Gly Ser Arg Cys Pro
 145                 150                 155                 160
 Leu Gly Val Gly Leu Ala Val Val Tyr Ala Thr Arg Leu Leu Pro Gln
                 165                 170                 175    
 Thr Gly Glu Thr Arg Ile Lys Asn Gly Gln Ala Ala Phe Trp Gly His
             180                 185                 190        
 Arg His Arg Arg His Gln Asn Phe Gly Val Phe Glu Pro Leu Gln Cys
         195                 200                 205            
 Leu Ala Gln Lys Gly Glu Leu Val Lys Leu Ala Pro Leu Gly Gly Leu
     210                 215                 220                
 Glu Ala Leu Val Val Arg Phe Leu Thr Lys Arg Phe Ile Gly Asp Tyr
 225                 230                 235                 240
 Glu Arg Asn Ala Gly Asn Leu Tyr Thr Arg Gln Val Gln Ile Glu Gly
                 245                 250                 255    
 Glu Thr Leu Ala Leu Gln Val Gln Asp Thr Pro Gly Ile Gln Val His
             260                 265                 270        
 Glu Asn Ser Leu Ser Cys Ser Glu Gln Leu Asn Arg Cys Ile Arg Trp
         275                 280                 285            
 Ala Asp Ala Val Val Ile Val Phe Ser Ile Thr Asp Tyr Lys Ser Tyr
     290                 295                 300                
 Glu Leu Ile Ser Gln Leu His Gln His Val Gln Gln Leu His Leu Gly
 305                 310                 315                 320
 Thr Arg Leu Pro Val Val Val Val Ala Asn Lys Ala Asp Leu Leu His
                 325                 330                 335    
 Ile Lys Gln Val Asp Pro Gln Leu Gly Leu Gln Leu Ala Ser Met Leu
             340                 345                 350        
 Gly Cys Ser Phe Tyr Glu Val Ser Val Ser Glu Asn Tyr Asn Asp Val
         355                 360                 365            
 Tyr Ser Ala Phe His Val Leu Cys Lys Glu Val Ser His Lys Gln Gln
     370                 375                 380                
 Pro Ser Ser Thr Pro Glu Lys Arg Arg Thr Ser Leu Ile Pro Arg Pro
 385                 390                 395                 400
 Lys Ser Pro Asn Met Gln Asp Leu Lys Arg Arg Phe Lys Gln Ala Leu
                 405                 410                 415    
 Ser Ala Lys Ala Ser Tyr Lys Pro Leu Leu Lys Gln Val Val Glu Glu
             420                 425                 430        
 Ile Phe His Pro Glu Arg Pro Asp Ser Val Asp Ile Glu His Met Ser
         435                 440                 445            
 Ser Gly Leu Thr Asp Leu Leu Lys Thr Gly Phe Ser Met Phe Met Lys
     450                 455                 460                
 Ser Asn Ile Thr Val Pro Leu Ile His
 465                 470            



      <210> 265
      <211> 128
      <212> PRT
      <213> Homo sapiens


      <400> 265
 Met Pro Leu Gly Lys Glu Val Lys Val Met Gln Cys Trp Arg Cys Lys
   1               5                  10                  15    
 Arg Tyr Gly His Arg Thr Gly Asp Lys Glu Cys Pro Phe Phe Ile Lys
              20                  25                  30        
 Gly Asn Gln Lys Leu Glu Gln Phe Arg Val Ala His Glu Asp Pro Met
          35                  40                  45            
 Tyr Asp Ile Ile Arg Asp Asn Lys Arg His Glu Lys Asp Val Arg Ile
      50                  55                  60                
 Gln Gln Leu Lys Gln Leu Leu Glu Asp Ser Thr Ser Asp Glu Asp Arg
  65                  70                  75                  80
 Ser Ser Ser Ser Ser Ser Glu Gly Lys Glu Lys His Lys Lys Lys Lys
                  85                  90                  95    
 Lys Lys Glu Lys His Lys Lys Arg Lys Lys Glu Lys Lys Lys Lys Lys
             100                 105                 110        
 Lys Arg Lys His Lys Ser Ser Lys Ser Asn Glu Gly Ser Asp Ser Glu
         115                 120                 125            





      <210> 266
      <211> 134
      <212> PRT
      <213> Homo sapiens


      <400> 266
 Met Pro Trp Val Pro Lys Gly Arg Gly Arg Ala Arg Ser Lys Phe Cys
   1               5                  10                  15    
 Ser Pro Glu Gln Pro Pro Cys Gly Pro Met Ala Pro Ala Gly Ser Val
              20                  25                  30        
 Gln Ala Thr Pro Pro Ala Gly Ser Arg His Pro Ser Pro Arg Thr Ser
          35                  40                  45            
 Val Phe Cys Leu Val Arg Thr Arg Ala Ser Cys Arg Asn Ala Ile Pro
      50                  55                  60                
 Ile Leu Arg Thr Asn Lys Ala Lys Leu Gly Ser Phe Gln Met Pro Ser
  65                  70                  75                  80
 His Gln Glu Glu Gln Lys Gln Pro Arg Val Arg Ser Ser Ala Val Lys
                  85                  90                  95    
 Trp Arg Gly Thr Ser Lys His Leu Pro Pro Pro Pro Met Glu Val Leu
             100                 105                 110        
 Met Asp Lys Ser Phe Ala Ser Leu Glu Ser Pro Glu Ser Ser Lys Ser
         115                 120                 125            
 Thr Glu Asn Ser Thr Lys
     130                



      <210> 267
      <211> 593
      <212> PRT
      <213> Homo sapiens


      <400> 267
 Met Glu Gly Ala Gly Pro Arg Gly Ala Gly Pro Ala Arg Arg Arg Gly
   1               5                  10                  15    
 Ala Gly Gly Pro Pro Ser Pro Leu Leu Pro Ser Leu Leu Leu Leu Leu
              20                  25                  30        
 Leu Leu Trp Met Leu Pro Asp Thr Val Ala Pro Gln Glu Leu Asn Pro
          35                  40                  45            
 Arg Gly Arg Asn Val Cys Arg Ala Pro Gly Ser Gln Val Pro Thr Cys
      50                  55                  60                
 Cys Ala Gly Trp Arg Gln Gln Gly Asp Glu Cys Gly Ile Ala Val Cys
  65                  70                  75                  80
 Glu Gly Asn Ser Thr Cys Ser Glu Asn Glu Val Cys Val Arg Pro Gly
                  85                  90                  95    
 Glu Cys Arg Cys Arg His Gly Tyr Phe Gly Ala Asn Cys Asp Thr Ser
             100                 105                 110        
 Glu Arg Gly Val Gly Pro Val Leu Val Gly Gly Ala Glu Ser Trp Arg
         115                 120                 125            
 Asp Gly Ala Gly Ser Lys Val Gly Arg Gly Arg Ile Arg Leu Arg Gly
     130                 135                 140                
 Gly Ser Pro Glu Val Ala Ala Gly Val Arg Asp Ala Gly Arg Phe Arg
 145                 150                 155                 160
 Leu Ala Gly Gly Thr Tyr Ser Ser Thr Gly Ala Phe His Pro Leu Arg
                 165                 170                 175    
 Ser Ser Pro Ala Glu Cys Pro Arg Gln Phe Trp Gly Pro Asp Cys Lys
             180                 185                 190        
 Glu Leu Cys Ser Cys His Pro His Gly Gln Cys Glu Asp Val Thr Gly
         195                 200                 205            
 Gln Cys Thr Cys His Ala Arg Arg Trp Gly Ala Arg Cys Glu His Ala
     210                 215                 220                
 Cys Gln Cys Gln His Gly Thr Cys His Pro Arg Ser Gly Ala Cys Arg
 225                 230                 235                 240
 Cys Glu Pro Gly Trp Trp Gly Ala Gln Cys Ala Ser Ala Cys Tyr Cys
                 245                 250                 255    
 Ser Ala Thr Ser Arg Cys Asp Pro Gln Thr Gly Ala Cys Leu Cys His
             260                 265                 270        
 Ala Gly Trp Trp Gly Arg Ser Cys Asn Asn Gln Cys Ala Cys Asn Ser
         275                 280                 285            
 Ser Pro Cys Glu Gln Gln Ser Gly Arg Cys Gln Cys Arg Glu Arg Thr
     290                 295                 300                
 Phe Gly Ala Arg Cys Asp Arg Tyr Cys Gln Cys Phe Arg Gly Arg Cys
 305                 310                 315                 320
 His Pro Val Asp Gly Thr Cys Ala Cys Glu Pro Gly Tyr Arg Gly Lys
                 325                 330                 335    
 Tyr Cys Arg Glu Pro Cys Pro Ala Gly Phe Tyr Gly Leu Gly Cys Arg
             340                 345                 350        
 Arg Arg Cys Gly Gln Cys Lys Gly Gln Gln Pro Cys Thr Val Ala Glu
         355                 360                 365            
 Gly Arg Cys Leu Thr Cys Glu Pro Gly Trp Asn Gly Thr Lys Cys Asp
     370                 375                 380                
 Gln Pro Cys Ala Thr Gly Phe Tyr Gly Glu Gly Cys Ser His Arg Cys
 385                 390                 395                 400
 Pro Pro Cys Arg Asp Gly His Ala Cys Asn His Val Thr Gly Lys Cys
                 405                 410                 415    
 Thr Arg Cys Asn Ala Gly Trp Ile Gly Asp Arg Cys Glu Thr Lys Cys
             420                 425                 430        
 Ser Asn Gly Thr Tyr Gly Glu Asp Cys Ala Phe Val Cys Ala Asp Cys
         435                 440                 445            
 Gly Ser Gly His Cys Asp Phe Gln Ser Gly Arg Cys Leu Cys Ser Pro
     450                 455                 460                
 Gly Val His Gly Pro His Cys Asn Val Thr Cys Pro Pro Gly Leu His
 465                 470                 475                 480
 Gly Ala Asp Cys Ala Gln Ala Cys Ser Cys His Glu Asp Thr Cys Asp
                 485                 490                 495    
 Pro Val Thr Gly Ala Cys His Leu Glu Thr Asn Gln Arg Lys Gly Val
             500                 505                 510        
 Met Gly Ala Gly Ala Leu Leu Val Leu Leu Val Cys Leu Leu Leu Ser
         515                 520                 525            
 Leu Leu Gly Cys Cys Cys Ala Cys Arg Gly Lys Asp Pro Thr Arg Arg
     530                 535                 540                
 Pro Arg Pro Ala Gly Ser Phe Ala Trp Glu Glu Glu Gly Ala Ala Pro
 545                 550                 555                 560
 Thr Met Arg Ala Leu Gln Ser His Gln His Glu Ala Ala Pro Asp Pro
                 565                 570                 575    
 Ala Pro Glu Ala Glu Thr Thr Gln Ser Arg Ser Gly Pro Pro Arg Pro
             580                 585                 590        
 Gly
    



      <210> 268
      <211> 858
      <212> PRT
      <213> Homo sapiens


      <400> 268
 Met Glu Lys Met Ser Arg Val Thr Thr Ala Leu Gly Gly Ser Val Leu
   1               5                  10                  15    
 Thr Gly Arg Thr Met His Cys His Leu Asp Ala Pro Ala Asn Ala Ile
              20                  25                  30        
 Ser Val Cys Arg Asp Ala Ala Gln Val Val Val Ala Gly Arg Ser Ile
          35                  40                  45            
 Phe Lys Ile Tyr Ala Ile Glu Glu Glu Gln Phe Val Glu Lys Leu Asn
      50                  55                  60                
 Leu Arg Val Gly Arg Lys Pro Ser Leu Asn Leu Ser Cys Ala Asp Val
  65                  70                  75                  80
 Val Trp His Gln Met Asp Glu Asn Leu Leu Ala Thr Ala Ala Thr Asn
                  85                  90                  95    
 Gly Val Val Val Thr Trp Asn Leu Gly Arg Pro Ser Arg Asn Lys Gln
             100                 105                 110        
 Asp Gln Leu Phe Thr Glu His Lys Arg Thr Val Asn Lys Val Cys Phe
         115                 120                 125            
 His Pro Thr Glu Ala His Val Leu Leu Ser Gly Ser Gln Asp Gly Phe
     130                 135                 140                
 Met Lys Cys Phe Asp Leu Arg Arg Lys Asp Ser Val Ser Thr Phe Ser
 145                 150                 155                 160
 Gly Glu Ala Thr Glu Ala Gly Pro Arg Glu Trp Ala Met Ala Gly Cys
                 165                 170                 175    
 Val Pro Ile Leu Pro Val Leu Ser Cys Arg Ile Leu Arg Leu His His
             180                 185                 190        
 Ser Phe Ala His Gly Pro Met Gln Asp Ala Glu Ser Thr Ala Asn Asp
         195                 200                 205            
 Ala Arg Glu Ser Trp Gly Cys Pro Leu Tyr Pro Leu Gly Leu Cys Ser
     210                 215                 220                
 Gly Pro Gln Ala Gly Gln Ser Glu Ser Val Arg Asp Val Gln Phe Ser
 225                 230                 235                 240
 Ile Arg Asp Tyr Phe Thr Phe Ala Ser Thr Phe Glu Asn Gly Asn Val
                 245                 250                 255    
 Gln Leu Trp Asp Ile Arg Arg Pro Asp Arg Cys Glu Arg Met Phe Thr
             260                 265                 270        
 Ala His Asn Gly Pro Val Phe Cys Cys Asp Trp His Pro Glu Asp Arg
         275                 280                 285            
 Gly Trp Leu Ala Thr Gly Gly Arg Asp Lys Met Val Lys Val Trp Asp
     290                 295                 300                
 Met Thr Thr His Arg Ala Lys Glu Met His Cys Val Gln Thr Ile Ala
 305                 310                 315                 320
 Ser Val Ala Arg Val Lys Trp Arg Pro Glu Cys Arg His His Leu Ala
                 325                 330                 335    
 Thr Cys Ser Met Met Gly Asp His Asn Ile Tyr Val Trp Asp Val Arg
             340                 345                 350        
 Arg Pro Phe Val Pro Ala Ala Met Phe Glu Glu His Arg Asp Val Thr
         355                 360                 365            
 Thr Gly Ile Ala Trp Arg His Pro His Asp Pro Ser Phe Leu Leu Ser
     370                 375                 380                
 Gly Ser Lys Asp Ser Ser Leu Cys Gln His Leu Phe Arg Asp Ala Ser
 385                 390                 395                 400
 Gln Pro Val Glu Arg Ala Asn Pro Glu Gly Leu Cys Tyr Gly Leu Phe
                 405                 410                 415    
 Gly Asp Leu Ala Phe Ala Ala Lys Glu Ser Leu Val Ala Ala Glu Ser
             420                 425                 430        
 Gly Arg Lys Pro Tyr Thr Gly Asp Arg Arg His Pro Ile Phe Phe Lys
         435                 440                 445            
 Arg Lys Leu Asp Pro Ala Glu Pro Phe Ala Gly Leu Ala Ser Ser Ala
     450                 455                 460                
 Leu Ser Val Phe Glu Thr Glu Pro Gly Gly Gly Gly Met Arg Trp Phe
 465                 470                 475                 480
 Val Asp Thr Ala Glu Arg Tyr Ala Leu Ala Gly Arg Pro Leu Ala Glu
                 485                 490                 495    
 Leu Cys Asp His Asn Ala Lys Val Ala Arg Glu Leu Gly Arg Asn Gln
             500                 505                 510        
 Val Ala Gln Thr Trp Thr Met Leu Arg Ile Ile Tyr Cys Ser Pro Gly
         515                 520                 525            
 Leu Val Pro Thr Ala Asn Leu Asn His Ser Val Gly Lys Gly Gly Ser
     530                 535                 540                
 Cys Gly Leu Pro Leu Met Asn Ser Phe Asn Leu Lys Asp Met Ala Pro
 545                 550                 555                 560
 Gly Leu Gly Ser Glu Thr Arg Leu Asp Arg Ser Lys Gly Asp Ala Arg
                 565                 570                 575    
 Ser Asp Thr Val Leu Leu Asp Ser Ser Ala Thr Leu Ile Thr Asn Glu
             580                 585                 590        
 Asp Asn Glu Glu Thr Glu Gly Ser Asp Val Pro Ala Asp Tyr Leu Leu
         595                 600                 605            
 Gly Asp Val Glu Gly Glu Glu Asp Glu Leu Tyr Leu Leu Asp Pro Glu
     610                 615                 620                
 His Ala His Pro Glu Asp Pro Glu Cys Val Leu Pro Gln Glu Ala Phe
 625                 630                 635                 640
 Pro Leu Arg His Glu Ile Val Asp Thr Pro Pro Gly Pro Glu His Leu
                 645                 650                 655    
 Gln Asp Lys Ala Asp Ser Pro His Val Ser Gly Ser Glu Ala Asp Val
             660                 665                 670        
 Ala Ser Leu Ala Pro Val Asp Ser Ser Phe Ser Leu Leu Ser Val Ser
         675                 680                 685            
 His Ala Leu Tyr Asp Ser Arg Leu Pro Pro Asp Phe Phe Gly Val Leu
     690                 695                 700                
 Val Arg Asp Met Leu His Phe Tyr Ala Glu Gln Gly Asp Val Gln Met
 705                 710                 715                 720
 Ala Val Ser Val Leu Ile Val Leu Gly Glu Arg Val Arg Lys Asp Ile
                 725                 730                 735    
 Asp Glu Gln Thr Gln Glu His Trp Tyr Thr Ser Tyr Ile Asp Leu Leu
             740                 745                 750        
 Gln Arg Phe Arg Leu Trp Asn Val Ser Asn Glu Val Val Lys Leu Ser
         755                 760                 765            
 Thr Ser Arg Ala Val Ser Cys Leu Asn Gln Ala Ser Thr Thr Leu His
     770                 775                 780                
 Val Asn Cys Ser His Cys Lys Arg Pro Met Ser Ser Arg Gly Trp Val
 785                 790                 795                 800
 Cys Asp Arg Cys His Arg Cys Ala Ser Met Cys Ala Val Cys His His
                 805                 810                 815    
 Val Val Lys Gly Leu Phe Val Trp Cys Gln Gly Cys Ser His Gly Gly
             820                 825                 830        
 His Leu Gln His Ile Met Lys Trp Leu Glu Gly Ser Ser His Cys Pro
         835                 840                 845            
 Ala Gly Cys Gly His Leu Cys Glu Tyr Ser
     850                 855            



      <210> 269
      <211> 790
      <212> PRT
      <213> Homo sapiens


      <400> 269
 Met Glu Lys Met Ser Arg Val Thr Thr Ala Leu Gly Gly Ser Val Leu
   1               5                  10                  15    
 Thr Gly Arg Thr Met His Cys His Leu Asp Ala Pro Ala Asn Ala Ile
              20                  25                  30        
 Ser Val Cys Arg Asp Ala Ala Gln Val Val Val Ala Gly Arg Ser Ile
          35                  40                  45            
 Phe Lys Ile Tyr Ala Ile Glu Glu Glu Gln Phe Val Glu Lys Leu Asn
      50                  55                  60                
 Leu Arg Val Gly Arg Lys Pro Ser Leu Asn Leu Ser Cys Ala Asp Val
  65                  70                  75                  80
 Val Trp His Gln Met Asp Glu Asn Leu Leu Ala Thr Ala Ala Thr Asn
                  85                  90                  95    
 Gly Val Val Val Thr Trp Asn Leu Gly Arg Pro Ser Arg Asn Lys Gln
             100                 105                 110        
 Asp Gln Leu Phe Thr Glu His Lys Arg Thr Val Asn Lys Val Cys Phe
         115                 120                 125            
 His Pro Thr Glu Ala His Val Leu Leu Ser Gly Ser Gln Asp Gly Phe
     130                 135                 140                
 Met Lys Cys Phe Asp Leu Arg Arg Lys Asp Ser Val Ser Thr Phe Ser
 145                 150                 155                 160
 Gly Gln Ser Glu Ser Val Arg Asp Val Gln Phe Ser Ile Arg Asp Tyr
                 165                 170                 175    
 Phe Thr Phe Ala Ser Thr Phe Glu Asn Gly Asn Val Gln Leu Trp Asp
             180                 185                 190        
 Ile Arg Arg Pro Asp Arg Cys Glu Arg Met Phe Thr Ala His Asn Gly
         195                 200                 205            
 Pro Val Phe Cys Cys Asp Trp His Pro Glu Asp Arg Gly Trp Leu Ala
     210                 215                 220                
 Thr Gly Gly Arg Asp Lys Met Val Lys Val Trp Asp Met Thr Thr His
 225                 230                 235                 240
 Arg Ala Lys Glu Met His Cys Val Gln Thr Ile Ala Ser Val Ala Arg
                 245                 250                 255    
 Val Lys Trp Arg Pro Glu Cys Arg His His Leu Ala Thr Cys Ser Met
             260                 265                 270        
 Met Gly Asp His Asn Ile Tyr Val Trp Asp Val Arg Arg Pro Phe Val
         275                 280                 285            
 Pro Ala Ala Met Phe Glu Glu His Arg Asp Val Thr Thr Gly Ile Ala
     290                 295                 300                
 Trp Arg His Pro His Asp Pro Ser Phe Leu Leu Ser Gly Ser Lys Asp
 305                 310                 315                 320
 Ser Ser Leu Cys Gln His Leu Phe Arg Asp Ala Ser Gln Pro Val Glu
                 325                 330                 335    
 Arg Ala Asn Pro Glu Gly Leu Cys Tyr Gly Leu Phe Gly Asp Leu Ala
             340                 345                 350        
 Phe Ala Ala Lys Glu Ser Leu Val Ala Ala Glu Ser Gly Arg Lys Pro
         355                 360                 365            
 Tyr Thr Gly Asp Arg Arg His Pro Ile Phe Phe Lys Arg Lys Leu Asp
     370                 375                 380                
 Pro Ala Glu Pro Phe Ala Gly Leu Ala Ser Ser Ala Leu Ser Val Phe
 385                 390                 395                 400
 Glu Thr Glu Pro Gly Gly Gly Gly Met Arg Trp Phe Val Asp Thr Ala
                 405                 410                 415    
 Glu Arg Tyr Ala Leu Ala Gly Arg Pro Leu Ala Glu Leu Cys Asp His
             420                 425                 430        
 Asn Ala Lys Val Ala Arg Glu Leu Gly Arg Asn Gln Val Ala Gln Thr
         435                 440                 445            
 Trp Thr Met Leu Arg Ile Ile Tyr Cys Ser Pro Gly Leu Val Pro Thr
     450                 455                 460                
 Ala Asn Leu Asn His Ser Val Gly Lys Gly Gly Ser Cys Gly Leu Pro
 465                 470                 475                 480
 Leu Met Asn Ser Phe Asn Leu Lys Asp Met Ala Pro Gly Leu Gly Ser
                 485                 490                 495    
 Glu Thr Arg Leu Asp Arg Ser Lys Gly Asp Ala Arg Ser Asp Thr Val
             500                 505                 510        
 Leu Leu Asp Ser Ser Ala Thr Leu Ile Thr Asn Glu Asp Asn Glu Glu
         515                 520                 525            
 Thr Glu Gly Ser Asp Val Pro Ala Asp Tyr Leu Leu Gly Asp Val Glu
     530                 535                 540                
 Gly Glu Glu Asp Glu Leu Tyr Leu Leu Asp Pro Glu His Ala His Pro
 545                 550                 555                 560
 Glu Asp Pro Glu Cys Val Leu Pro Gln Glu Ala Phe Pro Leu Arg His
                 565                 570                 575    
 Glu Ile Val Asp Thr Pro Pro Gly Pro Glu His Leu Gln Asp Lys Ala
             580                 585                 590        
 Asp Ser Pro His Val Ser Gly Ser Glu Ala Asp Val Ala Ser Leu Ala
         595                 600                 605            
 Pro Val Asp Ser Ser Phe Ser Leu Leu Ser Val Ser His Ala Leu Tyr
     610                 615                 620                
 Asp Ser Arg Leu Pro Pro Asp Phe Phe Gly Val Leu Val Arg Asp Met
 625                 630                 635                 640
 Leu His Phe Tyr Ala Glu Gln Gly Asp Val Gln Met Ala Val Ser Val
                 645                 650                 655    
 Leu Ile Val Leu Gly Glu Arg Val Arg Lys Asp Ile Asp Glu Gln Thr
             660                 665                 670        
 Gln Glu His Trp Tyr Thr Ser Tyr Ile Asp Leu Leu Gln Arg Phe Arg
         675                 680                 685            
 Leu Trp Asn Val Ser Asn Glu Val Val Lys Leu Ser Thr Ser Arg Ala
     690                 695                 700                
 Val Ser Cys Leu Asn Gln Ala Ser Thr Thr Leu His Val Asn Cys Ser
 705                 710                 715                 720
 His Cys Lys Arg Pro Met Ser Ser Arg Gly Trp Val Cys Asp Arg Cys
                 725                 730                 735    
 His Arg Cys Ala Ser Met Cys Ala Val Cys His His Val Val Lys Gly
             740                 745                 750        
 Leu Phe Val Trp Cys Gln Gly Cys Ser His Gly Gly His Leu Gln His
         755                 760                 765            
 Ile Met Lys Trp Leu Glu Gly Ser Ser His Cys Pro Ala Gly Cys Gly
     770                 775                 780                
 His Leu Cys Glu Tyr Ser
 785                 790



      <210> 270
      <211> 1190
      <212> PRT
      <213> Homo sapiens


      <400> 270
 Met Glu Val Asp Thr Glu Glu Lys Arg His Arg Thr Arg Ser Lys Gly
   1               5                  10                  15    
 Val Arg Val Pro Val Glu Pro Ala Ile Gln Glu Leu Phe Ser Cys Pro
              20                  25                  30        
 Thr Pro Gly Cys Asp Gly Ser Gly His Val Ser Gly Lys Tyr Ala Arg
          35                  40                  45            
 His Arg Ser Val Tyr Gly Cys Pro Leu Ala Lys Lys Arg Lys Thr Gln
      50                  55                  60                
 Asp Lys Gln Pro Gln Glu Pro Ala Pro Lys Arg Lys Pro Phe Ala Val
  65                  70                  75                  80
 Lys Ala Asp Ser Ser Ser Val Asp Glu Cys Asp Asp Ser Asp Gly Thr
                  85                  90                  95    
 Glu Asp Met Asp Glu Lys Glu Glu Asp Glu Gly Glu Glu Tyr Ser Glu
             100                 105                 110        
 Asp Asn Asp Glu Pro Gly Asp Glu Asp Glu Glu Asp Glu Glu Gly Asp
         115                 120                 125            
 Arg Glu Glu Glu Glu Glu Ile Glu Glu Glu Asp Glu Asp Asp Asp Glu
     130                 135                 140                
 Asp Gly Glu Asp Val Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu
 145                 150                 155                 160
 Glu Glu Glu Glu Glu Glu Glu Asn Glu Asp His Gln Met Asn Cys His
                 165                 170                 175    
 Asn Thr Arg Ile Met Gln Asp Thr Glu Lys Asp Asp Asn Asn Asn Asp
             180                 185                 190        
 Glu Tyr Asp Asn Tyr Asp Glu Leu Val Ala Lys Ser Leu Leu Asn Leu
         195                 200                 205            
 Gly Lys Ile Ala Glu Asp Ala Ala Tyr Arg Ala Arg Thr Glu Ser Glu
     210                 215                 220                
 Met Asn Ser Asn Thr Ser Asn Ser Leu Glu Asp Asp Ser Asp Lys Asn
 225                 230                 235                 240
 Glu Asn Leu Gly Arg Lys Ser Glu Leu Ser Leu Asp Leu Asp Ser Asp
                 245                 250                 255    
 Val Val Arg Glu Thr Val Asp Ser Leu Lys Leu Leu Ala Gln Gly His
             260                 265                 270        
 Gly Val Val Leu Ser Glu Asn Met Asn Asp Arg Asn Tyr Ala Asp Ser
         275                 280                 285            
 Met Ser Gln Gln Asp Ser Arg Asn Met Asn Tyr Val Met Leu Gly Lys
     290                 295                 300                
 Pro Met Asn Asn Gly Leu Met Glu Lys Met Val Glu Glu Ser Asp Glu
 305                 310                 315                 320
 Glu Val Cys Leu Ser Ser Leu Glu Cys Leu Arg Asn Gln Cys Phe Asp
                 325                 330                 335    
 Leu Ala Arg Lys Leu Ser Glu Thr Asn Pro Gln Glu Arg Asn Pro Gln
             340                 345                 350        
 Gln Asn Met Asn Ile Arg Gln His Val Arg Pro Glu Glu Asp Phe Pro
         355                 360                 365            
 Gly Arg Thr Pro Asp Arg Asn Tyr Ser Asp Met Leu Asn Leu Met Arg
     370                 375                 380                
 Leu Glu Glu Gln Leu Ser Pro Arg Ser Arg Val Phe Ala Ser Cys Ala
 385                 390                 395                 400
 Lys Glu Asp Gly Cys His Glu Arg Asp Asp Asp Thr Thr Ser Val Asn
                 405                 410                 415    
 Ser Asp Arg Ser Glu Glu Val Phe Asp Met Thr Lys Gly Asn Leu Thr
             420                 425                 430        
 Leu Leu Glu Lys Ala Ile Ala Leu Glu Thr Glu Arg Ala Lys Ala Met
         435                 440                 445            
 Arg Glu Lys Met Ala Met Glu Ala Gly Arg Arg Asp Asn Met Arg Ser
     450                 455                 460                
 Tyr Glu Asp Gln Ser Pro Arg Gln Leu Pro Gly Glu Asp Arg Lys Pro
 465                 470                 475                 480
 Lys Ser Ser Asp Ser His Val Lys Lys Pro Tyr Tyr Asp Pro Ser Arg
                 485                 490                 495    
 Thr Glu Lys Lys Glu Ser Lys Cys Pro Thr Pro Gly Cys Asp Gly Thr
             500                 505                 510        
 Gly His Val Thr Gly Leu Tyr Pro His His Arg Ser Leu Ser Gly Cys
         515                 520                 525            
 Pro His Lys Asp Arg Val Pro Pro Glu Ile Leu Ala Met His Glu Ser
     530                 535                 540                
 Val Leu Lys Cys Pro Thr Pro Gly Cys Thr Gly Arg Gly His Val Asn
 545                 550                 555                 560
 Ser Asn Arg Asn Ser His Arg Ser Leu Ser Gly Cys Pro Ile Ala Ala
                 565                 570                 575    
 Ala Glu Lys Leu Ala Lys Ala Gln Glu Lys His Gln Ser Cys Asp Val
             580                 585                 590        
 Ser Lys Ser Ser Gln Ala Ser Asp Arg Val Leu Arg Pro Met Cys Phe
         595                 600                 605            
 Val Lys Gln Leu Glu Ile Pro Gln Tyr Gly Tyr Arg Asn Asn Val Pro
     610                 615                 620                
 Thr Thr Thr Pro Arg Ser Asn Leu Ala Lys Glu Leu Glu Lys Tyr Ser
 625                 630                 635                 640
 Lys Thr Ser Phe Glu Tyr Asn Ser Tyr Asp Asn His Thr Tyr Gly Lys
                 645                 650                 655    
 Arg Ala Ile Ala Pro Lys Val Gln Thr Arg Asp Ile Ser Pro Lys Gly
             660                 665                 670        
 Tyr Asp Asp Ala Lys Arg Tyr Cys Lys Asp Pro Ser Pro Ser Ser Ser
         675                 680                 685            
 Ser Thr Ser Ser Tyr Ala Pro Ser Ser Ser Ser Asn Leu Ser Cys Gly
     690                 695                 700                
 Gly Gly Ser Ser Ala Ser Ser Thr Cys Ser Lys Ser Ser Phe Asp Tyr
 705                 710                 715                 720
 Thr His Asp Met Glu Ala Ala His Met Ala Ala Thr Ala Ile Leu Asn
                 725                 730                 735    
 Leu Ser Thr Arg Cys Arg Glu Met Pro Gln Asn Leu Ser Thr Lys Pro
             740                 745                 750        
 Gln Asp Leu Cys Ala Thr Arg Asn Pro Asp Met Glu Val Asp Glu Asn
         755                 760                 765            
 Gly Thr Leu Asp Leu Ser Met Asn Lys Gln Arg Pro Arg Asp Ser Cys
     770                 775                 780                
 Cys Pro Ile Leu Thr Pro Leu Glu Pro Met Ser Pro Gln Gln Gln Ala
 785                 790                 795                 800
 Val Met Asn Asn Arg Cys Phe Gln Leu Gly Glu Gly Asp Cys Trp Asp
                 805                 810                 815    
 Leu Pro Val Asp Tyr Thr Lys Met Lys Pro Arg Arg Ile Asp Glu Asp
             820                 825                 830        
 Glu Ser Lys Asp Ile Thr Pro Glu Asp Leu Asp Pro Phe Gln Glu Ala
         835                 840                 845            
 Leu Glu Glu Arg Arg Tyr Pro Gly Glu Val Thr Ile Pro Ser Pro Lys
     850                 855                 860                
 Pro Lys Tyr Pro Gln Cys Lys Glu Ser Lys Lys Asp Leu Ile Thr Leu
 865                 870                 875                 880
 Ser Gly Cys Pro Leu Ala Asp Lys Ser Ile Arg Ser Met Leu Ala Thr
                 885                 890                 895    
 Ser Ser Gln Glu Leu Lys Cys Pro Thr Pro Gly Cys Asp Gly Ser Gly
             900                 905                 910        
 His Ile Thr Gly Asn Tyr Ala Ser His Arg Ser Leu Ser Gly Cys Pro
         915                 920                 925            
 Arg Ala Lys Lys Ser Gly Ile Arg Ile Ala Gln Ser Lys Glu Asp Lys
     930                 935                 940                
 Glu Asp Gln Glu Pro Ile Arg Cys Pro Val Pro Gly Cys Asp Gly Gln
 945                 950                 955                 960
 Gly His Ile Thr Gly Lys Tyr Ala Ser His Arg Ser Ala Ser Gly Cys
                 965                 970                 975    
 Pro Leu Ala Ala Lys Arg Gln Lys Asp Gly Tyr Leu Asn Gly Ser Gln
             980                 985                 990        
 Phe Ser Trp Lys Ser Val Lys Thr Glu Gly Met Ser Cys Pro Thr Pro
         995                1000                1005            
 Gly Cys Asp Gly Ser Gly His Val Ser Gly Ser Phe Leu Thr His Arg
    1010                1015                1020                
 Ser Leu Ser Gly Cys Pro Arg Ala Thr Ser Ala Met Lys Lys Ala Lys
1025                1030                1035                1040
 Leu Ser Gly Glu Gln Met Leu Thr Ile Lys Gln Arg Ala Ser Asn Gly
                1045                1050                1055    
 Ile Glu Asn Asp Glu Glu Ile Lys Gln Leu Asp Glu Glu Ile Lys Glu
            1060                1065                1070        
 Leu Asn Glu Ser Asn Ser Gln Met Glu Ala Asp Met Ile Lys Leu Arg
        1075                1080                1085            
 Thr Gln Ile Thr Thr Met Glu Ser Asn Leu Lys Thr Ile Glu Glu Glu
    1090                1095                1100                
 Asn Lys Val Ile Glu Gln Gln Asn Glu Ser Leu Leu His Glu Leu Ala
1105                1110                1115                1120
 Asn Leu Ser Gln Ser Leu Ile His Ser Leu Ala Asn Ile Gln Leu Pro
                1125                1130                1135    
 His Met Asp Pro Ile Asn Glu Gln Asn Phe Asp Ala Tyr Val Thr Thr
            1140                1145                1150        
 Leu Thr Glu Met Tyr Thr Asn Gln Asp Arg Tyr Gln Ser Pro Glu Asn
        1155                1160                1165            
 Lys Ala Leu Leu Glu Asn Ile Lys Gln Ala Val Arg Gly Ile Gln Phe
    1170                1175                1180                
 Arg Ser Glu Gln Leu Leu
1185                1190



      <210> 271
      <211> 712
      <212> PRT
      <213> Homo sapiens


      <400> 271
 Met Glu Gly Ser Gly Thr Gly Lys Arg Arg Gly Lys Ala Ala Lys Thr
   1               5                  10                  15    
 Ser Leu Arg Ile Met Asp Ala Arg Ala Gln Leu Leu Leu Arg Val Pro
              20                  25                  30        
 His Pro Gly Pro Ser Leu Thr Ser Gly Ala Leu Thr His Ile Arg Asp
          35                  40                  45            
 Pro His Pro Gly Leu Ser Pro Thr Ser Gly Thr Leu Met Pro Gly Arg
      50                  55                  60                
 Arg Arg Gly Gly Pro His Ser Gly Pro Cys Thr Pro Ser Pro Glu Val
  65                  70                  75                  80
 Pro Pro Arg Ser Ala Gly Leu Gly Ala Val Tyr Ser Gly Pro Gly Glu
                  85                  90                  95    
 Ala Val Val Ala Pro Ser Ala Ser Val Ala Val Met Glu Glu Ile Pro
             100                 105                 110        
 Ala Gln Glu Ala Ala Gly Ser Pro Arg Val Gln Phe Gln Ser Leu Glu
         115                 120                 125            
 Thr Gln Ser Glu Cys Leu Ser Pro Glu Pro Gln Phe Val Gln Asp Thr
     130                 135                 140                
 Asp Met Glu Arg Gly Leu Thr Gly Ala Pro Pro Val Pro Gln Val Pro
 145                 150                 155                 160
 Ala Leu Pro Arg Glu Gly Ser Pro Gly Asp Gln Ala Ala Ala Leu Leu
                 165                 170                 175    
 Thr Ala Arg Tyr Gln Ser Ser Gln Asp Val Leu Phe Gln Glu Phe Val
             180                 185                 190        
 Thr Phe Glu Asp Val Ala Val His Leu Thr Arg Glu Glu Trp Gly Tyr
         195                 200                 205            
 Leu Asp Pro Val Gln Arg Asp Leu Tyr Arg Glu Val Met Leu Glu Asn
     210                 215                 220                
 Tyr Gly Asn Val Val Ser Leu Gly Phe Pro Ile Ser Lys Pro Asp Gly
 225                 230                 235                 240
 Ile Ser Gln Leu Glu Gln Asp Leu Gln Val Phe Asp Leu Glu Thr Lys
                 245                 250                 255    
 Thr Arg Glu Val Leu Arg Asp Asp Cys Ser Asp Gly Glu Thr Arg Glu
             260                 265                 270        
 Glu Asn Lys Leu Leu Ile Pro Lys Gln Lys Ile Ser Glu Glu Val His
         275                 280                 285            
 Ser Tyr Lys Val Arg Val Gly Arg Leu Lys His Asp Ile Thr Gln Val
     290                 295                 300                
 Pro Glu Thr Arg Glu Val Tyr Lys Ser Glu Asp Arg Leu Glu Arg Leu
 305                 310                 315                 320
 Gln Glu Ile Leu Arg Lys Phe Leu Tyr Leu Glu Arg Glu Phe Arg Gln
                 325                 330                 335    
 Ile Thr Ile Ser Lys Glu Thr Phe Thr Ser Glu Lys Asn Asn Glu Cys
             340                 345                 350        
 His Glu Pro Glu Lys Ser Phe Ser Leu Asp Ser Thr Ile Asp Ala Asp
         355                 360                 365            
 Gln Arg Val Leu Arg Ile Gln Asn Thr Asp Asp Asn Asp Lys Tyr Asp
     370                 375                 380                
 Met Ser Phe Asn Gln Asn Ser Ala Ser Gly Lys His Glu His Leu Asn
 385                 390                 395                 400
 Leu Thr Glu Asp Phe Gln Ser Ser Glu Cys Lys Glu Ser Leu Met Asp
                 405                 410                 415    
 Leu Ser His Leu Asn Lys Trp Glu Ser Ile Pro Asn Thr Glu Lys Ser
             420                 425                 430        
 Tyr Lys Cys Asp Val Cys Gly Lys Ile Phe His Gln Ser Ser Ala Leu
         435                 440                 445            
 Thr Arg His Gln Arg Ile His Thr Arg Glu Lys Pro Tyr Lys Cys Lys
     450                 455                 460                
 Glu Cys Glu Lys Ser Phe Ser Gln Ser Ser Ser Leu Ser Arg His Lys
 465                 470                 475                 480
 Arg Ile His Thr Arg Glu Lys Pro Tyr Lys Cys Glu Ala Ser Asp Lys
                 485                 490                 495    
 Ser Cys Glu Ala Ser Asp Lys Ser Cys Ser Pro Ser Ser Gly Ile Ile
             500                 505                 510        
 Gln His Lys Lys Ile His Thr Arg Ala Lys Ser Tyr Lys Cys Ser Ser
         515                 520                 525            
 Cys Glu Arg Val Phe Ser Arg Ser Val His Leu Thr Gln His Gln Lys
     530                 535                 540                
 Ile His Lys Glu Met Pro Cys Lys Cys Thr Val Cys Gly Ser Asp Phe
 545                 550                 555                 560
 Cys His Thr Ser Tyr Leu Leu Glu His Gln Arg Val His His Glu Glu
                 565                 570                 575    
 Lys Ala Tyr Glu Tyr Asp Glu Tyr Gly Leu Ala Tyr Ile Lys Gln Gln
             580                 585                 590        
 Gly Ile His Phe Arg Glu Lys Pro Tyr Thr Cys Ser Glu Cys Gly Lys
         595                 600                 605            
 Asp Phe Arg Leu Asn Ser His Leu Ile Gln His Gln Arg Ile His Thr
     610                 615                 620                
 Gly Glu Lys Ala His Glu Cys Asn Glu Cys Gly Lys Ala Phe Ser Gln
 625                 630                 635                 640
 Thr Ser Cys Leu Ile Gln His His Lys Met His Arg Lys Glu Lys Ser
                 645                 650                 655    
 Tyr Glu Cys Asn Glu Tyr Glu Gly Ser Phe Ser His Ser Ser Asp Leu
             660                 665                 670        
 Ile Leu Gln Gln Glu Val Leu Thr Arg Gln Lys Ala Phe Asp Cys Asp
         675                 680                 685            
 Val Trp Glu Lys Asn Ser Ser Gln Arg Ala His Leu Val Gln His Gln
     690                 695                 700                
 Ser Ile His Thr Lys Glu Asn Ser
 705                 710        



      <210> 272
      <211> 101
      <212> PRT
      <213> Homo sapiens


      <400> 272
 Met Leu Trp Asp Leu Asn Glu Gly Lys His Leu Tyr Thr Leu Asp Gly
   1               5                  10                  15    
 Gly Asp Ile Ile Asn Ala Leu Cys Phe Ser Pro Asn Arg Tyr Trp Leu
              20                  25                  30        
 Cys Ala Ala Thr Gly Pro Ser Ile Lys Ile Trp Asp Leu Glu Gly Lys
          35                  40                  45            
 Ile Ile Val Asp Glu Leu Lys Gln Glu Val Ile Ser Thr Ser Ser Lys
      50                  55                  60                
 Ala Glu Pro Pro Gln Cys Thr Ser Leu Ala Trp Ser Ala Asp Gly Gln
  65                  70                  75                  80
 Thr Leu Phe Ala Gly Tyr Thr Asp Asn Leu Val Arg Val Trp Gln Val
                  85                  90                  95    
 Thr Ile Gly Thr Arg
             100    



      <210> 273
      <211> 374
      <212> PRT
      <213> Homo sapiens


      <400> 273
 Met Ser Arg Val Pro Ser Pro Pro Pro Pro Ala Glu Met Ser Ser Gly
   1               5                  10                  15    
 Pro Val Ala Glu Ser Trp Cys Tyr Thr Gln Ile Lys Val Val Lys Phe
              20                  25                  30        
 Ser Tyr Met Trp Thr Ile Asn Asn Phe Ser Phe Cys Arg Glu Glu Met
          35                  40                  45            
 Gly Glu Val Ile Lys Ser Ser Thr Phe Ser Ser Gly Ala Asn Asp Lys
      50                  55                  60                
 Leu Lys Trp Cys Leu Arg Val Asn Pro Lys Gly Leu Asp Glu Glu Ser
  65                  70                  75                  80
 Lys Asp Tyr Leu Ser Leu Tyr Leu Leu Leu Val Ser Cys Pro Lys Ser
                  85                  90                  95    
 Glu Val Arg Ala Lys Phe Lys Phe Ser Ile Leu Asn Ala Lys Gly Glu
             100                 105                 110        
 Glu Thr Lys Ala Met Glu Ser Gln Arg Ala Tyr Arg Phe Val Gln Gly
         115                 120                 125            
 Lys Asp Trp Gly Phe Lys Lys Phe Ile Arg Arg Asp Phe Leu Leu Asp
     130                 135                 140                
 Glu Ala Asn Gly Leu Leu Pro Asp Asp Lys Leu Thr Leu Phe Cys Glu
 145                 150                 155                 160
 Val Ser Val Val Gln Asp Ser Val Asn Ile Ser Gly Gln Asn Thr Met
                 165                 170                 175    
 Asn Met Val Lys Val Pro Glu Cys Arg Leu Ala Asp Glu Leu Gly Gly
             180                 185                 190        
 Leu Trp Glu Asn Ser Arg Phe Thr Asp Cys Cys Leu Cys Val Ala Gly
         195                 200                 205            
 Gln Glu Phe Gln Ala His Lys Ala Ile Leu Ala Ala Arg Ser Pro Val
     210                 215                 220                
 Phe Ser Ala Met Phe Glu His Glu Met Glu Glu Ser Lys Lys Asn Arg
 225                 230                 235                 240
 Val Glu Ile Asn Asp Val Glu Pro Glu Val Phe Lys Glu Met Met Cys
                 245                 250                 255    
 Phe Ile Tyr Thr Gly Lys Ala Pro Asn Leu Asp Lys Met Ala Asp Asp
             260                 265                 270        
 Leu Leu Ala Ala Ala Asp Lys Tyr Ala Leu Glu Arg Leu Lys Val Met
         275                 280                 285            
 Cys Glu Asp Ala Leu Cys Ser Asn Leu Ser Val Glu Asn Ala Ala Glu
     290                 295                 300                
 Ile Leu Ile Leu Ala Asp Leu His Ser Ala Asp Gln Leu Lys Thr Gln
 305                 310                 315                 320
 Ala Val Asp Phe Ile Asn Tyr His Ala Ser Asp Val Leu Glu Thr Ser
                 325                 330                 335    
 Gly Trp Lys Ser Met Val Val Ser His Pro His Leu Val Ala Glu Ala
             340                 345                 350        
 Tyr Arg Ser Leu Ala Ser Ala Gln Cys Pro Phe Leu Gly Pro Pro Arg
         355                 360                 365            
 Lys Arg Leu Lys Gln Ser
     370                



      <210> 274
      <211> 470
      <212> PRT
      <213> Homo sapiens


      <400> 274
 Met Ala Pro Val Val Thr Gly Lys Phe Gly Glu Arg Pro Pro Pro Lys
   1               5                  10                  15    
 Arg Leu Thr Arg Glu Ala Met Arg Asn Tyr Leu Lys Glu Arg Gly Asp
              20                  25                  30        
 Gln Thr Val Leu Ile Leu His Ala Lys Val Ala Gln Lys Ser Tyr Gly
          35                  40                  45            
 Asn Glu Lys Arg Phe Phe Cys Pro Pro Pro Cys Val Tyr Leu Met Gly
      50                  55                  60                
 Ser Gly Trp Lys Lys Lys Lys Glu Gln Met Glu Arg Asp Gly Cys Ser
  65                  70                  75                  80
 Glu Gln Glu Ser Gln Pro Cys Ala Phe Ile Gly Ile Gly Asn Ser Asp
                  85                  90                  95    
 Gln Glu Met Gln Gln Leu Asn Leu Glu Gly Lys Asn Tyr Cys Thr Ala
             100                 105                 110        
 Lys Thr Leu Tyr Ile Ser Asp Ser Asp Lys Arg Lys His Phe Met Leu
         115                 120                 125            
 Ser Val Lys Met Phe Tyr Gly Asn Ser Asp Asp Ile Gly Val Phe Leu
     130                 135                 140                
 Ser Lys Arg Ile Lys Val Ile Ser Lys Pro Ser Lys Lys Lys Gln Ser
 145                 150                 155                 160
 Leu Lys Asn Ala Asp Leu Cys Ile Ala Ser Gly Thr Lys Val Ala Leu
                 165                 170                 175    
 Phe Asn Arg Leu Arg Ser Gln Thr Val Ser Thr Arg Tyr Leu His Val
             180                 185                 190        
 Glu Gly Val Asp Asp Asp Glu Ser Glu Gly Glu Glu Phe Thr Val Arg
         195                 200                 205            
 Asp Gly Tyr Ile His Tyr Gly Gln Thr Val Lys Leu Val Cys Ser Val
     210                 215                 220                
 Thr Gly Met Ala Leu Pro Arg Leu Ile Ile Arg Lys Val Asp Lys Gln
 225                 230                 235                 240
 Thr Ala Leu Leu Asp Ala Asp Asp Pro Val Ser Gln Leu His Lys Cys
                 245                 250                 255    
 Ala Phe Tyr Leu Lys Asp Thr Glu Arg Met Tyr Leu Cys Leu Ser Gln
             260                 265                 270        
 Glu Arg Ile Ile Gln Phe Gln Ala Thr Pro Cys Pro Lys Glu Pro Asn
         275                 280                 285            
 Lys Glu Met Ile Asn Asp Gly Ala Ser Trp Thr Ile Ile Ser Thr Asp
     290                 295                 300                
 Lys Ala Glu Tyr Thr Phe Tyr Glu Gly Met Gly Pro Val Leu Ala Pro
 305                 310                 315                 320
 Val Thr Pro Val Pro Val Val Glu Ser Leu Gln Leu Asn Gly Gly Gly
                 325                 330                 335    
 Asp Val Ala Met Leu Glu Leu Thr Gly Gln Asn Phe Thr Pro Asn Leu
             340                 345                 350        
 Arg Val Trp Phe Gly Asp Val Glu Ala Glu Thr Met Tyr Arg Cys Gly
         355                 360                 365            
 Glu Ser Met Leu Cys Val Val Pro Asp Ile Ser Ala Phe Arg Glu Gly
     370                 375                 380                
 Trp Arg Trp Val Arg Gln Pro Val Gln Val Pro Val Thr Leu Val Arg
 385                 390                 395                 400
 Asn Asp Gly Ile Ile Tyr Ser Thr Ser Leu Thr Phe Thr Tyr Thr Pro
                 405                 410                 415    
 Glu Pro Gly Pro Arg Pro His Cys Ser Ala Ala Gly Ala Ile Leu Arg
             420                 425                 430        
 Ala Asn Ser Ser Gln Val Pro Pro Asn Glu Ser Asn Thr Asn Ser Glu
         435                 440                 445            
 Gly Ser Tyr Thr Asn Ala Ser Thr Asn Ser Thr Ser Val Thr Ser Ser
     450                 455                 460                
 Thr Ala Thr Val Val Ser
 465                 470



      <210> 275
      <211> 144
      <212> PRT
      <213> Homo sapiens


      <400> 275
 Met Arg Lys Ile Asp Leu Cys Leu Ser Ser Glu Gly Ser Glu Val Ile
   1               5                  10                  15    
 Leu Ala Thr Ser Ser Asp Glu Lys His Pro Pro Glu Asn Ile Ile Asp
              20                  25                  30        
 Gly Asn Pro Glu Thr Phe Trp Thr Thr Thr Gly Met Phe Pro Gln Glu
          35                  40                  45            
 Phe Ile Ile Cys Phe His Lys His Val Arg Ile Glu Arg Leu Val Ile
      50                  55                  60                
 Gln Ser Tyr Phe Val Gln Thr Leu Lys Ile Glu Lys Ser Thr Ser Lys
  65                  70                  75                  80
 Glu Pro Val Asp Phe Glu Gln Trp Ile Glu Lys Asp Leu Val His Thr
                  85                  90                  95    
 Glu Gly Gln Leu Gln Asn Glu Glu Ile Val Ala His Asp Gly Ser Ala
             100                 105                 110        
 Thr Tyr Leu Arg Phe Ile Ile Val Ser Ala Phe Asp His Phe Ala Ser
         115                 120                 125            
 Val His Ser Val Ser Ala Glu Gly Thr Val Val Ser Asn Leu Ser Ser
     130                 135                 140                





      <210> 276
      <211> 121
      <212> PRT
      <213> Homo sapiens


      <400> 276
 Met Arg Lys Ile Asp Leu Cys Leu Ser Ser Glu Gly Ser Glu Val Ile
   1               5                  10                  15    
 Leu Ala Thr Ser Ser Asp Glu Lys His Pro Pro Glu Asn Ile Ile Asp
              20                  25                  30        
 Gly Asn Pro Glu Thr Phe Trp Thr Thr Thr Gly Met Phe Pro Gln Glu
          35                  40                  45            
 Phe Ile Ile Cys Phe His Lys His Val Arg Ile Glu Arg Leu Val Ile
      50                  55                  60                
 Gln Ser Tyr Phe Asp Leu Val His Thr Glu Gly Gln Leu Gln Asn Glu
  65                  70                  75                  80
 Glu Ile Val Ala His Asp Gly Ser Ala Thr Tyr Leu Arg Phe Ile Ile
                  85                  90                  95    
 Val Ser Ala Phe Asp His Phe Ala Ser Val His Ser Val Ser Ala Glu
             100                 105                 110        
 Gly Thr Val Val Ser Asn Leu Ser Ser
         115                 120    



      <210> 277
      <211> 83
      <212> PRT
      <213> Homo sapiens


      <400> 277
 Met Leu Arg Asn Leu Leu Ala Leu Arg Gln Ile Gly Gln Arg Thr Ile
   1               5                  10                  15    
 Ser Thr Ala Ser Arg Arg His Phe Lys Asn Lys Val Pro Glu Lys Gln
              20                  25                  30        
 Lys Leu Phe Gln Glu Asp Asp Glu Ile Pro Leu Tyr Leu Lys Gly Gly
          35                  40                  45            
 Val Ala Asp Ala Leu Leu Tyr Arg Ala Thr Met Ile Leu Thr Val Gly
      50                  55                  60                
 Gly Thr Ala Tyr Ala Ile Tyr Glu Leu Ala Val Ala Ser Phe Pro Lys
  65                  70                  75                  80
 Lys Gln Glu
            



      <210> 278
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 278
 Met Cys Val Ala Gln Val Leu Thr Ala His Leu Leu Pro Pro Arg Gln
   1               5                  10                  15    
 Ala Leu Gly Ser Leu Cys Ser Pro Trp Ala Ala Pro Arg Val Gly Pro
              20                  25                  30        
 Leu Pro Pro Ala Pro Ala Met Val Arg Ile Ser Lys Pro Lys Thr Phe
          35                  40                  45            
 Gln Ala Tyr Leu Asp Asp Cys His Arg Arg Tyr Ser Cys Ala His Cys
      50                  55                  60                
 Arg Ala His Leu Ala Asn His Asp Asp Leu Ile Ser Lys Ser Phe Gln
  65                  70                  75                  80
 Gly Ser Gln Gly Arg Ala Tyr Leu Phe Asn Ser Val Val Asn Val Gly
                  85                  90                  95    
 Cys Gly Pro Ala Glu Glu Arg Val Leu Leu Thr Gly Leu His Ala Val
             100                 105                 110        
 Ala Asp Ile His Cys Glu Asn Cys Lys Thr Thr Leu Gly Trp Lys Tyr
         115                 120                 125            
 Glu Gln Ala Phe Glu Ser Ser Gln Lys Tyr Lys Glu Gly Lys Tyr Ile
     130                 135                 140                
 Ile Glu Leu Asn His Met Ile Lys Asp Asn Gly Trp Asp
 145                 150                 155        



      <210> 279
      <211> 282
      <212> PRT
      <213> Homo sapiens


      <400> 279
 Met Ala Arg Arg Gly Trp Ala Gln Thr Gly Trp Gly Cys Gly Gln Ala
   1               5                  10                  15    
 Trp Gly Ala Ser Gly Gly Gly Arg Ser Cys Glu Glu Leu Thr Ala Val
              20                  25                  30        
 Leu Thr Pro Pro Gln Leu Leu Gly Arg Arg Phe Asn Phe Phe Ile Gln
          35                  40                  45            
 Gln Lys Cys Gly Phe Arg Lys Ala Pro Arg Lys Val Glu Pro Arg Arg
      50                  55                  60                
 Ser Asp Pro Gly Thr Ser Gly Glu Ala Tyr Lys Arg Ser Ala Leu Ile
  65                  70                  75                  80
 Pro Pro Val Glu Glu Thr Val Phe Tyr Pro Ser Pro Tyr Pro Ile Arg
                  85                  90                  95    
 Ser Leu Ile Lys Pro Leu Phe Phe Thr Val Gly Ile Asn Lys Trp Trp
             100                 105                 110        
 Asn Asn Leu Ser Asp Gly Gln Arg Thr Val Thr Gly Ile Ile Ala Ala
         115                 120                 125            
 Asn Val Leu Val Phe Cys Leu Trp Arg Val Pro Ser Leu Gln Arg Thr
     130                 135                 140                
 Met Ile Arg Tyr Phe Thr Ser Asn Pro Ala Ser Ser Val Ile Ser Asn
 145                 150                 155                 160
 Phe Val Ser Tyr Val Gly Lys Val Ala Thr Gly Arg Tyr Gly Pro Ser
                 165                 170                 175    
 Leu Gly Ala Ser Gly Ala Ile Met Thr Val Leu Ala Ala Val Cys Thr
             180                 185                 190        
 Lys Ile Pro Glu Gly Arg Leu Ala Ile Ile Phe Leu Pro Met Phe Thr
         195                 200                 205            
 Phe Thr Ala Gly Asn Ala Leu Lys Ala Ile Ile Ala Met Asp Thr Ala
     210                 215                 220                
 Gly Met Ile Leu Gly Trp Lys Phe Phe Asp His Ala Ala His Leu Gly
 225                 230                 235                 240
 Gly Ala Leu Phe Gly Ile Trp Tyr Val Thr Tyr Gly His Glu Leu Ile
                 245                 250                 255    
 Trp Lys Asn Arg Glu Pro Leu Val Lys Ile Trp His Glu Ile Arg Thr
             260                 265                 270        
 Asn Gly Pro Lys Lys Gly Gly Gly Ser Lys
         275                 280        



      <210> 280
      <211> 200
      <212> PRT
      <213> Homo sapiens


      <400> 280
 Met Ala Thr Lys Ala Val Cys Val Leu Lys Gly Asp Gly Pro Val Gln
   1               5                  10                  15    
 Gly Ile Ile Asn Phe Glu Gln Lys Ala Arg Ala Gly Thr Glu Ala Cys
              20                  25                  30        
 Leu Arg Gly Arg Ser His Pro Leu Val Pro Pro Arg Thr Phe Val Arg
          35                  40                  45            
 Ser Gly Ser Pro Ala Arg Pro Arg Gly Arg Pro Gly Pro Ala Pro Gly
      50                  55                  60                
 Pro Gly Pro Cys Arg Pro Glu Ser Asn Gly Pro Val Lys Val Trp Gly
  65                  70                  75                  80
 Ser Ile Lys Gly Leu Thr Glu Gly Leu His Gly Phe His Val His Glu
                  85                  90                  95    
 Phe Gly Asp Asn Thr Ala Gly Cys Thr Ser Ala Gly Pro His Phe Asn
             100                 105                 110        
 Pro Leu Ser Arg Lys His Gly Gly Pro Lys Asp Glu Glu Arg His Val
         115                 120                 125            
 Gly Asp Leu Gly Asn Val Thr Ala Asp Lys Asp Gly Val Ala Asp Val
     130                 135                 140                
 Ser Ile Glu Asp Ser Val Ile Ser Leu Ser Gly Asp His Cys Ile Ile
 145                 150                 155                 160
 Gly Arg Thr Leu Val Val His Glu Lys Ala Asp Asp Leu Gly Lys Gly
                 165                 170                 175    
 Gly Asn Glu Glu Ser Thr Lys Thr Gly Asn Ala Gly Ser Arg Leu Ala
             180                 185                 190        
 Cys Gly Val Ile Gly Ile Ala Gln
         195                 200



      <210> 281
      <211> 245
      <212> PRT
      <213> Homo sapiens


      <400> 281
 Met Ala Gly Leu Glu Leu Leu Ser Asp Gln Gly Tyr Arg Val Asp Gly
   1               5                  10                  15    
 Arg Arg Ala Gly Glu Leu Arg Lys Ile Gln Ala Arg Met Gly Val Phe
              20                  25                  30        
 Ala Gln Ala Asp Gly Ser Ala Tyr Ile Glu Gln Gly Asn Thr Lys Ala
          35                  40                  45            
 Leu Ala Val Val Tyr Gly Pro His Glu Ile Arg Gly Ser Arg Ala Arg
      50                  55                  60                
 Ala Leu Pro Asp Arg Ala Leu Val Asn Cys Gln Tyr Ser Ser Ala Thr
  65                  70                  75                  80
 Phe Ser Thr Gly Glu Arg Lys Arg Arg Pro His Gly Asp Arg Lys Ser
                  85                  90                  95    
 Cys Glu Met Gly Leu Gln Leu Arg Gln Thr Phe Glu Ala Ala Ile Leu
             100                 105                 110        
 Thr Gln Leu His Pro Arg Ser Gln Ile Asp Ile Tyr Val Gln Val Leu
         115                 120                 125            
 Gln Ala Asp Gly Gly Thr Tyr Ala Ala Cys Val Asn Ala Ala Thr Leu
     130                 135                 140                
 Ala Val Leu Asp Ala Gly Ile Pro Met Arg Asp Phe Val Cys Ala Cys
 145                 150                 155                 160
 Ser Ala Gly Phe Val Asp Gly Thr Ala Leu Ala Asp Leu Ser His Val
                 165                 170                 175    
 Glu Glu Ala Ala Gly Gly Pro Gln Leu Ala Leu Ala Leu Leu Pro Ala
             180                 185                 190        
 Ser Gly Gln Ile Ala Leu Leu Glu Met Asp Ala Arg Leu His Glu Asp
         195                 200                 205            
 His Leu Glu Arg Val Leu Glu Ala Ala Ala Gln Ala Ala Arg Asp Val
     210                 215                 220                
 His Thr Leu Leu Asp Arg Val Val Arg Gln His Val Arg Glu Ala Ser
 225                 230                 235                 240
 Ile Leu Leu Gly Asp
                 245



      <210> 282
      <211> 1066
      <212> PRT
      <213> Homo sapiens


      <400> 282
 Met Ala Cys Trp Arg Ala Asp Val Cys Cys Val Leu Phe Arg Gln His
   1               5                  10                  15    
 Ser Pro Phe Asn Val Leu Trp Thr Ser Ser Cys Leu Tyr Val Leu Pro
              20                  25                  30        
 Pro Met Cys Ser Ser Arg Arg Pro Ala Ala Leu Asn Phe Ile Lys Asp
          35                  40                  45            
 Asn Ser Arg Ala Leu Ile Gln Arg Met Gly Met Thr Ile Ile Lys Gln
      50                  55                  60                
 Ile Thr Asp Asp Leu Phe Val Trp Asn Val Leu Asn Arg Glu Glu Val
  65                  70                  75                  80
 Asn Ile Ile Cys Cys Glu Lys Val Glu Gln Asp Ala Ala Arg Gly Ile
                  85                  90                  95    
 Ile His Met Ile Leu Lys Lys Gly Ser Glu Ser Cys Asn Leu Phe Leu
             100                 105                 110        
 Lys Ser Leu Lys Glu Trp Asn Tyr Pro Leu Phe Gln Asp Leu Asn Gly
         115                 120                 125            
 Gln Ser Leu Phe His Gln Thr Ser Glu Gly Asp Leu Asp Asp Leu Ala
     130                 135                 140                
 Gln Asp Leu Lys Asp Leu Tyr His Thr Pro Ser Phe Leu Asn Phe Tyr
 145                 150                 155                 160
 Pro Leu Gly Glu Asp Ile Asp Ile Ile Phe Asn Leu Lys Ser Thr Phe
                 165                 170                 175    
 Thr Glu Pro Val Leu Trp Arg Lys Asp Gln His His His Arg Val Glu
             180                 185                 190        
 Gln Leu Thr Leu Asn Gly Leu Leu Gln Ala Leu Gln Ser Pro Cys Ile
         195                 200                 205            
 Ile Glu Gly Glu Ser Gly Lys Gly Lys Ser Thr Leu Leu Gln Arg Ile
     210                 215                 220                
 Ala Met Leu Trp Gly Ser Gly Lys Cys Lys Ala Leu Thr Lys Phe Lys
 225                 230                 235                 240
 Phe Val Phe Phe Leu Arg Leu Ser Arg Ala Gln Gly Gly Leu Phe Glu
                 245                 250                 255    
 Thr Leu Cys Asp Gln Leu Leu Asp Ile Pro Gly Thr Ile Arg Lys Gln
             260                 265                 270        
 Thr Phe Met Ala Met Leu Leu Lys Leu Arg Gln Arg Val Leu Phe Leu
         275                 280                 285            
 Leu Asp Gly Tyr Asn Glu Phe Lys Pro Gln Asn Cys Pro Glu Ile Glu
     290                 295                 300                
 Ala Leu Ile Lys Glu Asn His Arg Phe Lys Asn Met Val Ile Val Thr
 305                 310                 315                 320
 Thr Thr Thr Glu Cys Leu Arg His Ile Arg Gln Phe Gly Ala Leu Thr
                 325                 330                 335    
 Ala Glu Val Gly Asp Met Thr Glu Asp Ser Ala Gln Ala Leu Ile Arg
             340                 345                 350        
 Glu Val Leu Ile Lys Glu Leu Ala Glu Gly Leu Leu Leu Gln Ile Gln
         355                 360                 365            
 Lys Ser Arg Cys Leu Arg Asn Leu Met Lys Thr Pro Leu Phe Val Val
     370                 375                 380                
 Ile Thr Cys Ala Ile Gln Met Gly Glu Ser Glu Phe His Ser His Thr
 385                 390                 395                 400
 Gln Thr Thr Leu Phe His Thr Phe Tyr Asp Leu Leu Ile Gln Lys Asn
                 405                 410                 415    
 Lys His Lys His Lys Gly Val Ala Ala Ser Asp Phe Ile Arg Ser Leu
             420                 425                 430        
 Asp His Cys Gly Asp Leu Ala Leu Glu Gly Val Phe Ser His Lys Phe
         435                 440                 445            
 Asp Phe Glu Leu Gln Asp Val Ser Ser Val Asn Glu Asp Val Leu Leu
     450                 455                 460                
 Thr Thr Gly Leu Leu Cys Lys Tyr Thr Ala Gln Arg Phe Lys Pro Lys
 465                 470                 475                 480
 Tyr Lys Phe Phe His Lys Ser Phe Gln Glu Tyr Thr Ala Gly Arg Arg
                 485                 490                 495    
 Leu Ser Ser Leu Leu Thr Ser His Glu Pro Glu Glu Val Thr Lys Gly
             500                 505                 510        
 Asn Gly Tyr Leu Gln Lys Met Val Ser Ile Ser Asp Ile Thr Ser Thr
         515                 520                 525            
 Tyr Ser Ser Leu Leu Arg Tyr Thr Cys Gly Ser Ser Val Glu Ala Thr
     530                 535                 540                
 Arg Ala Val Met Lys His Leu Ala Ala Val Tyr Gln His Gly Cys Leu
 545                 550                 555                 560
 Leu Gly Leu Ser Ile Ala Lys Arg Pro Leu Trp Arg Gln Glu Ser Leu
                 565                 570                 575    
 Gln Ser Val Lys Asn Thr Thr Glu Gln Glu Ile Leu Lys Ala Ile Asn
             580                 585                 590        
 Ile Asn Ser Phe Val Glu Cys Gly Ile His Leu Tyr Gln Glu Ser Thr
         595                 600                 605            
 Ser Lys Ser Ala Leu Ser Gln Glu Phe Glu Ala Phe Phe Gln Gly Lys
     610                 615                 620                
 Ser Leu Tyr Ile Asn Ser Gly Asn Ile Pro Asp Tyr Leu Phe Asp Phe
 625                 630                 635                 640
 Phe Glu His Leu Pro Asn Cys Ala Ser Ala Leu Asp Phe Ile Lys Leu
                 645                 650                 655    
 Gly Phe Tyr Gly Gly Ala Met Ala Ser Trp Glu Lys Ala Ala Glu Asp
             660                 665                 670        
 Thr Gly Gly Ile His Met Glu Glu Ala Pro Glu Thr Tyr Ile Pro Ser
         675                 680                 685            
 Arg Ala Val Ser Leu Phe Phe Asn Trp Lys Gln Glu Phe Arg Thr Leu
     690                 695                 700                
 Glu Val Thr Leu Arg Asp Phe Ser Lys Leu Asn Lys Gln Asp Ile Arg
 705                 710                 715                 720
 Tyr Leu Gly Lys Ile Phe Ser Ser Ala Thr Ser Leu Arg Leu Gln Ile
                 725                 730                 735    
 Lys Arg Cys Ala Gly Val Ala Gly Ser Leu Ser Leu Val Leu Ser Thr
             740                 745                 750        
 Cys Lys Asn Ile Tyr Ser Leu Met Val Glu Ala Ser Pro Leu Thr Ile
         755                 760                 765            
 Glu Asp Glu Arg His Ile Thr Ser Val Thr Asn Leu Lys Thr Leu Ser
     770                 775                 780                
 Ile His Asp Leu Gln Asn Gln Arg Leu Pro Gly Gly Leu Thr Asp Ser
 785                 790                 795                 800
 Leu Gly Asn Leu Lys Asn Leu Thr Lys Leu Ile Met Asp Asn Ile Lys
                 805                 810                 815    
 Met Asn Glu Glu Asp Ala Ile Lys Leu Ala Glu Gly Leu Lys Asn Leu
             820                 825                 830        
 Lys Lys Met Cys Leu Phe His Leu Thr His Leu Ser Asp Ile Gly Glu
         835                 840                 845            
 Gly Met Asp Tyr Ile Val Lys Ser Leu Ser Ser Glu Pro Cys Asp Leu
     850                 855                 860                
 Glu Glu Ile Gln Leu Val Ser Cys Cys Leu Ser Ala Asn Ala Val Lys
 865                 870                 875                 880
 Ile Leu Ala Gln Asn Leu His Asn Leu Val Lys Leu Ser Ile Leu Asp
                 885                 890                 895    
 Leu Ser Glu Asn Tyr Leu Glu Lys Asp Gly Asn Glu Ala Leu His Glu
             900                 905                 910        
 Leu Ile Asp Arg Met Asn Val Leu Glu Gln Leu Thr Ala Leu Met Leu
         915                 920                 925            
 Pro Trp Gly Cys Asp Val Gln Gly Ser Leu Ser Ser Leu Leu Lys His
     930                 935                 940                
 Leu Glu Glu Val Pro Gln Leu Val Lys Leu Gly Leu Lys Asn Trp Arg
 945                 950                 955                 960
 Leu Thr Asp Thr Glu Ile Arg Ile Leu Gly Ala Phe Phe Gly Lys Asn
                 965                 970                 975    
 Pro Leu Lys Asn Phe Gln Gln Leu Asn Leu Ala Gly Asn Arg Val Ser
             980                 985                 990        
 Ser Asp Gly Trp Leu Ala Phe Met Gly Val Phe Glu Asn Leu Lys Gln
         995                1000                1005            
 Leu Val Phe Phe Asp Phe Ser Thr Lys Glu Phe Leu Pro Asp Pro Ala
    1010                1015                1020                
 Leu Val Arg Lys Leu Ser Gln Val Leu Ser Lys Leu Thr Phe Leu Gln
1025                1030                1035                1040
 Glu Ala Arg Leu Val Gly Trp Gln Phe Asp Asp Asp Asp Leu Ser Val
                1045                1050                1055    
 Ile Thr Gly Ala Phe Lys Leu Val Thr Ala
            1060                1065    



      <210> 283
      <211> 92
      <212> PRT
      <213> Homo sapiens


      <400> 283
 Met Asp Glu Glu Leu Leu His Arg Asp Glu Gln Arg Lys Trp Phe Leu
   1               5                  10                  15    
 Glu Met Arg Ser Thr Pro Gly Glu Asp Ala Ala Asn Asn Val Glu Met
              20                  25                  30        
 Thr Thr Lys Asp Leu Asn Tyr Asp Arg Asn Leu Val Asp Lys Ala Val
          35                  40                  45            
 Val Gly Phe Glu Arg Thr Asp Ser Asn Phe Glu Arg Ser Cys Thr Val
      50                  55                  60                
 Gly Lys Gln His Cys Met Ile Gln Arg Asn Cys Ser Trp Lys Glu Glu
  65                  70                  75                  80
 Tyr Met Asp Ala Ala Asn Phe Ile Val Val Leu Phe
                  85                  90        



      <210> 284
      <211> 813
      <212> PRT
      <213> Homo sapiens


      <400> 284
 Met Arg Arg Asp Pro Thr Pro Pro Arg Gly Leu Pro Arg Gln Arg Pro
   1               5                  10                  15    
 Thr Pro Ser Pro Arg Thr Arg Ser Arg Gly His Gln Ser Gln Arg Pro
              20                  25                  30        
 Lys Ala Lys Ser Glu Pro Gln Pro Ala Pro Ala Ala Thr Pro Gly Gly
          35                  40                  45            
 Arg Arg Ala Trp Glu Pro Arg Ala Gln Ala Gly Cys Pro Pro Pro Pro
      50                  55                  60                
 Arg Ala Ala Ser Pro Arg Arg Leu Val Gln Gly Glu Arg Pro Glu Ser
  65                  70                  75                  80
 Gly Asn Arg Ser Arg Gln Ala Ala Tyr Pro Arg Arg Ala Ser Arg Ala
                  85                  90                  95    
 Arg Thr Cys Thr Thr Arg Leu Pro Pro Thr Leu Arg Gln Arg Ala Leu
             100                 105                 110        
 Thr Gln Arg Pro Cys Ser Val Pro Arg Thr Asn Arg Lys Leu Arg Arg
         115                 120                 125            
 Gly Pro Gly Pro Ile Thr Leu Arg Arg Pro Glu Ser Cys Ser Arg Pro
     130                 135                 140                
 Ala Phe Ala Thr Glu Ala His Asp Ala Gln Ala Leu Pro Arg Pro Pro
 145                 150                 155                 160
 Gly Val Ile Ala Arg Gln Ser Ala Met His Arg Ala Leu Ala Ala Leu
                 165                 170                 175    
 Lys Asn Lys Pro Leu Asn His Val His Lys Val Val Lys Glu Arg Leu
             180                 185                 190        
 Cys Pro Trp Leu Cys Ser Arg Gln Pro Glu Pro Phe Gly Val Lys Phe
         195                 200                 205            
 His His Ala His Cys Lys Lys Phe His Ser Lys Asn Gly Asn Asp Leu
     210                 215                 220                
 His Pro Leu Gly Gly Pro Val Phe Ser Gln Val Ser Asp Cys Asp Arg
 225                 230                 235                 240
 Leu Glu Gln Asn Val Lys Asn Glu Glu Ser Gln Met Phe Tyr Arg Arg
                 245                 250                 255    
 Leu Ser Asn Leu Thr Ser Ser Glu Glu Val Leu Ser Phe Ile Ser Thr
             260                 265                 270        
 Met Glu Thr Leu Pro Asp Thr Met Ala Ala Gly Ala Leu Gln Arg Ile
         275                 280                 285            
 Cys Glu Val Glu Lys Lys Asp Gly Asp Gln Gly Leu Pro Lys Glu Ile
     290                 295                 300                
 Leu Glu Asn Ser Ile Phe Gln Ala Leu Cys Phe Gln Phe Glu Lys Glu
 305                 310                 315                 320
 Pro Ser Gln Leu Ser Asn Thr Ser Leu Val Thr Ala Leu Gln Ala Leu
                 325                 330                 335    
 Ile Leu Leu His Val Asp Pro Gln Ser Ser Leu Leu Leu Asn Leu Val
             340                 345                 350        
 Ala Glu Cys Gln Asn Arg Leu Arg Lys Gly Gly Met Glu Val Arg Asn
         355                 360                 365            
 Leu Cys Ile Leu Gly Glu Ser Leu Ile Thr Leu His Ser Ser Gly Cys
     370                 375                 380                
 Val Thr Leu Glu Leu Ile Ile Asn Gln Leu Gln Gly Glu Lys Leu Glu
 385                 390                 395                 400
 Thr Phe Thr Pro Glu Asp Ile Val Ala Leu Tyr Arg Ile Leu Gln Ala
                 405                 410                 415    
 Cys Thr Glu Lys Val Asp Glu His Gln Thr Phe Leu Asn Lys Ile Asn
             420                 425                 430        
 Asn Phe Ser Leu Ser Ile Val Ser Asn Leu Ser Pro Lys Leu Ile Ser
         435                 440                 445            
 Gln Met Leu Thr Ala Leu Val Val Leu Asp Gln Ser Gln Ala Phe Pro
     450                 455                 460                
 Leu Ile Ile Lys Leu Gly Lys Tyr Val Val Arg His Val Pro His Phe
 465                 470                 475                 480
 Thr Asn Glu Glu Leu Arg Arg Val Leu Glu Ala Phe Ile Tyr Phe Gly
                 485                 490                 495    
 His His Asp Thr Phe Phe Thr Lys Ala Leu Glu His Arg Val Ala Ala
             500                 505                 510        
 Val Cys Leu Thr Leu Asp Pro Glu Val Val Cys Arg Val Met Glu Tyr
         515                 520                 525            
 Cys Ser Arg Glu Leu Ile Leu Ser Lys Pro Ile Leu Asn Ala Val Ala
     530                 535                 540                
 Glu Thr Phe Val Cys Gln Thr Glu Lys Phe Ser Pro Arg Gln Ile Ser
 545                 550                 555                 560
 Ala Leu Met Glu Pro Phe Gly Lys Leu Asn Tyr Leu Pro Pro Asn Ala
                 565                 570                 575    
 Ser Ala Leu Phe Arg Lys Leu Glu Asn Val Leu Phe Thr His Phe Asn
             580                 585                 590        
 Tyr Phe Pro Pro Lys Ser Leu Leu Lys Leu Leu His Ser Cys Ser Leu
         595                 600                 605            
 Asn Glu Cys His Pro Val Asn Phe Leu Ala Lys Ile Phe Lys Pro Leu
     610                 615                 620                
 Phe Leu Gln Arg Leu Gln Gly Lys Glu Ser His Leu Asp Thr Leu Ser
 625                 630                 635                 640
 Arg Ala Gln Leu Thr Gln Leu Phe Leu Ala Ser Val Leu Glu Cys Pro
                 645                 650                 655    
 Phe Tyr Lys Gly Pro Lys Leu Leu Pro Lys Tyr Gln Val Lys Ser Phe
             660                 665                 670        
 Leu Thr Pro Cys Cys Ser Leu Glu Thr Pro Val Asp Ser Gln Leu Tyr
         675                 680                 685            
 Arg Tyr Val Lys Ile Gly Leu Thr Asn Leu Leu Gly Ala Arg Leu Tyr
     690                 695                 700                
 Phe Ala Pro Lys Val Leu Thr Pro Tyr Cys Tyr Thr Ile Asp Val Glu
 705                 710                 715                 720
 Ile Lys Leu Asp Glu Glu Gly Phe Val Leu Pro Ser Thr Ala Asn Glu
                 725                 730                 735    
 Asp Ile His Lys Arg Ile Ala Leu Cys Ile Asp Gly Pro Lys Arg Phe
             740                 745                 750        
 Cys Ser Asn Ser Lys His Leu Leu Gly Lys Glu Ala Ile Lys Gln Arg
         755                 760                 765            
 His Leu Gln Leu Leu Gly Tyr Gln Val Val Gln Ile Pro Tyr His Glu
     770                 775                 780                
 Ile Gly Met Leu Lys Ser Arg Arg Glu Leu Val Glu Tyr Leu Gln Arg
 785                 790                 795                 800
 Lys Leu Phe Ser Gln Asn Thr Val His Trp Leu Gln Glu
                 805                 810            



      <210> 285
      <211> 52
      <212> PRT
      <213> Homo sapiens


      <400> 285
 Met Lys Ala Tyr Cys Glu Arg Gln Gly Leu Ser Met Arg Gln Ile Arg
   1               5                  10                  15    
 Phe Arg Phe Asp Gly Gln Pro Ile Asn Glu Thr Asp Thr Pro Ala Gln
              20                  25                  30        
 Leu Glu Met Glu Asp Glu Asp Thr Ile Asp Val Phe Gln Gln Gln Thr
          35                  40                  45            
 Gly Gly Val Tyr
      50        



      <210> 286
      <211> 402
      <212> PRT
      <213> Homo sapiens


      <400> 286
 Met Ala Ser Ile Ile Ala Arg Val Gly Asn Ser Arg Arg Leu Asn Ala
   1               5                  10                  15    
 Pro Leu Pro Pro Trp Ala His Ser Met Leu Arg Ser Leu Gly Arg Ser
              20                  25                  30        
 Leu Gly Pro Ile Met Ala Ser Met Ala Asp Arg Asn Met Lys Leu Phe
          35                  40                  45            
 Ser Gly Arg Val Val Pro Ala Gln Gly Glu Glu Thr Phe Glu Asn Trp
      50                  55                  60                
 Leu Thr Gln Val Asn Gly Val Leu Pro Asp Trp Asn Met Ser Glu Glu
  65                  70                  75                  80
 Glu Lys Leu Lys Arg Leu Met Lys Thr Leu Arg Gly Pro Ala Arg Glu
                  85                  90                  95    
 Val Met Arg Val Leu Gln Ala Thr Asn Pro Asn Leu Ser Val Ala Asp
             100                 105                 110        
 Phe Leu Arg Ala Met Lys Leu Val Phe Gly Glu Ser Glu Ser Ser Val
         115                 120                 125            
 Thr Ala His Gly Lys Phe Phe Asn Thr Leu Gln Ala Gln Gly Glu Lys
     130                 135                 140                
 Ala Ser Leu Tyr Val Ile Arg Leu Glu Val Gln Leu Gln Asn Ala Ile
 145                 150                 155                 160
 Gln Ala Gly Ile Ile Ala Glu Lys Asp Ala Asn Arg Thr Arg Leu Gln
                 165                 170                 175    
 Gln Leu Leu Leu Gly Gly Glu Leu Ser Arg Asp Leu Arg Leu Arg Leu
             180                 185                 190        
 Lys Asp Phe Leu Arg Met Tyr Ala Asn Glu Gln Glu Arg Leu Pro Asn
         195                 200                 205            
 Phe Leu Glu Leu Ile Arg Met Val Arg Glu Glu Glu Asp Trp Asp Asp
     210                 215                 220                
 Ala Phe Ile Lys Arg Lys Arg Pro Lys Arg Ser Glu Ser Met Val Glu
 225                 230                 235                 240
 Arg Ala Val Ser Pro Val Ala Phe Gln Gly Ser Pro Pro Ile Val Ile
                 245                 250                 255    
 Gly Ser Ala Asp Cys Asn Val Ile Glu Ile Asp Asp Thr Leu Asp Asp
             260                 265                 270        
 Ser Asp Glu Asp Val Ile Leu Val Glu Ser Gln Asp Pro Pro Leu Pro
         275                 280                 285            
 Ser Trp Gly Ala Pro Pro Leu Arg Asp Arg Ala Arg Pro Gln Asp Glu
     290                 295                 300                
 Val Leu Val Ile Asp Ser Pro His Asn Ser Arg Ala Gln Phe Pro Ser
 305                 310                 315                 320
 Thr Ser Gly Gly Ser Gly Tyr Lys Asn Asn Gly Pro Gly Glu Met Arg
                 325                 330                 335    
 Arg Ala Arg Lys Arg Lys His Thr Ile Arg Cys Ser Tyr Cys Gly Glu
             340                 345                 350        
 Glu Gly His Ser Lys Glu Thr Cys Asp Asn Glu Ser Asp Lys Ala Gln
         355                 360                 365            
 Val Phe Glu Asn Leu Ile Ile Thr Leu Gln Glu Leu Thr His Thr Glu
     370                 375                 380                
 Met Glu Arg Ser Arg Val Ala Pro Gly Glu Tyr Asn Asp Phe Ser Glu
 385                 390                 395                 400
 Pro Leu
        



      <210> 287
      <211> 538
      <212> PRT
      <213> Homo sapiens


      <400> 287
 Met Ala Tyr Leu Ser Glu Cys Arg Leu Arg Leu Glu Lys Gly Phe Ile
   1               5                  10                  15    
 Leu Asp Gly Val Ala Val Ser Thr Ala Ala Arg Ala Tyr Gly Arg Ser
              20                  25                  30        
 Arg Pro Lys Leu Trp Ser Ala Ile Pro Pro Tyr Asn Ala Gln Glu Asp
          35                  40                  45            
 Tyr His Ala Arg Ser Tyr Phe Gln Ser His Val Val Pro Pro Leu Leu
      50                  55                  60                
 Arg Lys Thr Asp Gln Ser Leu Arg Thr Leu Val Asp Cys Val Phe Ser
  65                  70                  75                  80
 Met Gly Asn Ala Ser Asp Tyr Ala Trp Leu Ala Ser His Thr Thr Pro
                  85                  90                  95    
 Arg Gly Met Gly Lys Pro Arg Gly His Ser Leu Gln Gln Val Thr Gly
             100                 105                 110        
 His Asp His Tyr Asn Ala Asp Leu Lys Pro Ile Asp Gly Phe Asn Gly
         115                 120                 125            
 Arg Glu Ser Gly Thr Ser Gly Asn Val Ala Thr Arg Ser Ser Gln Asn
     130                 135                 140                
 Glu Thr Ser Thr Ala Lys Ala Ser Thr Ala Glu Pro Gly Pro Leu Gln
 145                 150                 155                 160
 Asn Leu Gln Val Thr Pro Thr Ser Gln Ser Ala Thr Glu Pro Cys Thr
                 165                 170                 175    
 Ser Ser Phe Arg Asp Ala Asp Ala Met Cys Glu Arg Leu Leu Glu Glu
             180                 185                 190        
 Asn Leu Ala Ile Val Glu Asp Ile Leu Pro Ser His Ala Cys Leu Gly
         195                 200                 205            
 Tyr Gly Arg Asn Leu Lys Lys Ser Trp His Pro Gln Thr Leu Arg Asn
     210                 215                 220                
 Val Glu Lys Val Trp Lys Ala Glu Gln Lys His Glu Ala Glu Arg Lys
 225                 230                 235                 240
 Lys Ile Glu Glu Leu Gln Arg Glu Leu Arg Glu Glu Arg Ala Arg Glu
                 245                 250                 255    
 Glu Met Gln Arg Tyr Ala Glu Asp Val Gly Ala Val Lys Lys Lys Glu
             260                 265                 270        
 Glu Lys Leu Asp Trp Met Tyr Gln Gly Pro Gly Gly Met Val Asn Arg
         275                 280                 285            
 Asp Glu Tyr Leu Leu Gly Arg Pro Ile Asp Lys Tyr Val Phe Glu Lys
     290                 295                 300                
 Met Glu Glu Lys Glu Ala Gly Cys Ser Ser Glu Thr Gly Leu Leu Pro
 305                 310                 315                 320
 Gly Ser Ile Phe Ala Pro Ser Gly Ala Asn Ser Leu Leu Asp Met Ala
                 325                 330                 335    
 Ser Lys Ile Arg Glu Asp Pro Leu Phe Ile Ile Arg Lys Lys Glu Glu
             340                 345                 350        
 Glu Lys Lys Arg Glu Val Leu Asn Asn Pro Val Lys Met Lys Lys Ile
         355                 360                 365            
 Lys Glu Leu Leu Gln Met Ser Leu Glu Lys Lys Glu Lys Lys Lys Lys
     370                 375                 380                
 Lys Glu Lys Lys Lys Lys His Lys Lys His Lys His Arg Ser Ser Ser
 385                 390                 395                 400
 Ser Asp Arg Ser Ser Ser Glu Asp Glu His Ser Ala Gly Arg His Asn
                 405                 410                 415    
 Ser Lys Val Asn Arg Arg Glu Thr Gly Gln Thr Arg Ser Pro Ser Pro
             420                 425                 430        
 Lys Lys Glu Val Tyr Gln Arg Arg His Ala Pro Gly Tyr Thr Arg Lys
         435                 440                 445            
 Leu Ser Ala Glu Glu Leu Glu Arg Lys Arg Gln Glu Met Met Glu Asn
     450                 455                 460                
 Ala Lys Trp Arg Glu Glu Glu Arg Leu Asn Ile Leu Lys Arg His Ala
 465                 470                 475                 480
 Lys Asp Glu Glu Arg Glu Gln Arg Leu Glu Lys Leu Asp Ser Arg Asp
                 485                 490                 495    
 Gly Lys Phe Ile His Arg Met Lys Leu Glu Ser Ala Ser Thr Ser Ser
             500                 505                 510        
 Leu Glu Asp Arg Val Lys Arg Asn Ile Tyr Ser Leu Gln Arg Thr Ser
         515                 520                 525            
 Val Ala Leu Glu Lys Asn Phe Met Lys Arg
     530                 535            



      <210> 288
      <211> 414
      <212> PRT
      <213> Homo sapiens


      <400> 288
 Met Ala Tyr Leu Ser Glu Cys Arg Leu Arg Leu Glu Lys Gly Phe Ile
   1               5                  10                  15    
 Leu Asp Gly Val Ala Val Ser Thr Ala Ala Arg Ala Tyr Gly Arg Ser
              20                  25                  30        
 Arg Pro Lys Leu Trp Ser Ala Ile Pro Pro Tyr Asn Ala Gln Glu Asp
          35                  40                  45            
 Tyr His Ala Arg Ser Tyr Phe Gln Ser His Val Val Pro Pro Leu Leu
      50                  55                  60                
 Arg Lys Thr Asp Gln Ser Leu Arg Thr Leu Val Asp Cys Val Phe Ser
  65                  70                  75                  80
 Met Gly Asn Ala Ser Asp Tyr Ala Trp Leu Ala Ser His Thr Thr Pro
                  85                  90                  95    
 Arg Gly Met Gly Lys Pro Arg Gly His Ser Leu Gln Gln Val Thr Gly
             100                 105                 110        
 His Asp His Tyr Asn Ala Asp Leu Lys Pro Ile Asp Gly Phe Asn Gly
         115                 120                 125            
 Arg Glu Ser Gly Thr Ser Gly Asn Val Ala Thr Arg Ser Ser Gln Asn
     130                 135                 140                
 Glu Thr Ser Thr Ala Lys Ala Ser Thr Ala Glu Pro Gly Pro Leu Gln
 145                 150                 155                 160
 Asn Leu Gln Val Thr Pro Thr Ser Gln Ser Ala Thr Glu Pro Cys Thr
                 165                 170                 175    
 Ser Ser Phe Arg Asp Ala Asp Ala Met Cys Glu Arg Leu Leu Glu Glu
             180                 185                 190        
 Asn Leu Ala Ile Val Glu Asp Ile Leu Pro Ser His Ala Cys Leu Gly
         195                 200                 205            
 Tyr Gly Arg Asn Leu Lys Lys Ser Trp His Pro Gln Thr Leu Arg Asn
     210                 215                 220                
 Val Glu Lys Val Trp Lys Ala Glu Gln Lys His Glu Ala Glu Arg Lys
 225                 230                 235                 240
 Lys Ile Glu Glu Leu Gln Arg Glu Leu Arg Glu Glu Arg Ala Arg Glu
                 245                 250                 255    
 Glu Met Gln Arg Tyr Ala Glu Asp Val Gly Ala Val Lys Lys Lys Glu
             260                 265                 270        
 Glu Lys Leu Asp Trp Met Tyr Gln Gly Pro Gly Gly Met Val Asn Arg
         275                 280                 285            
 Asp Glu Tyr Leu Leu Gly Arg Pro Ile Asp Lys Tyr Val Phe Glu Lys
     290                 295                 300                
 Met Glu Glu Lys Glu Ala Gly Cys Ser Ser Glu Thr Gly Leu Leu Pro
 305                 310                 315                 320
 Gly Ser Ile Phe Ala Pro Ser Gly Ala Asn Ser Leu Leu Asp Met Ala
                 325                 330                 335    
 Ser Lys Ile Arg Glu Asp Pro Leu Phe Ile Ile Arg Lys Lys Glu Glu
             340                 345                 350        
 Glu Lys Lys Arg Glu Val Leu Asn Asn Pro Val Lys Met Lys Lys Ile
         355                 360                 365            
 Lys Glu Leu Leu Gln Met Ser Leu Glu Lys Lys Glu Lys Lys Lys Lys
     370                 375                 380                
 Lys Glu Lys Lys Lys Lys His Lys Lys His Lys His Arg Ser Ser Ser
 385                 390                 395                 400
 Ser Asp Arg Ser Ser Ser Glu Asp Glu His Ser Ala Gln Leu
                 405                 410                



      <210> 289
      <211> 549
      <212> PRT
      <213> Homo sapiens


      <400> 289
 Met Asn Lys Arg Gly Lys Tyr Thr Thr Leu Asn Leu Glu Glu Lys Met
   1               5                  10                  15    
 Lys Val Leu Ser Arg Ile Glu Ala Gly Arg Ser Leu Lys Ser Val Met
              20                  25                  30        
 Asp Glu Phe Gly Ile Ser Lys Ser Thr Phe Tyr Asp Ile Lys Lys Asn
          35                  40                  45            
 Lys Lys Leu Ile Leu Asp Phe Val Leu Lys Gln Asp Met Pro Leu Val
      50                  55                  60                
 Gly Ala Glu Lys Arg Lys Arg Thr Thr Gly Ala Lys Tyr Gly Asp Val
  65                  70                  75                  80
 Asp Asp Ala Val Tyr Met Trp Tyr Gln Gln Lys Arg Ser Ala Gly Val
                  85                  90                  95    
 Pro Val Arg Gly Val Glu Leu Gln Ala Ala Ala Glu Arg Phe Ala Arg
             100                 105                 110        
 Cys Phe Gly Arg Thr Asp Phe Lys Ala Ser Thr Gly Trp Leu Phe Arg
         115                 120                 125            
 Phe Arg Asn Arg His Ala Ile Gly Asn Arg Lys Gly Cys Gly Glu Gln
     130                 135                 140                
 Val Leu Ser Ser Val Ser Glu Asn Val Glu Pro Phe Arg Gln Lys Leu
 145                 150                 155                 160
 Ser Met Ile Ile Lys Glu Glu Lys Leu Cys Leu Ala Gln Leu Tyr Ser
                 165                 170                 175    
 Gly Asp Glu Thr Asp Leu Phe Trp Lys Ser Met Pro Glu Asn Ser Gln
             180                 185                 190        
 Ala Ser Arg Lys Asp Ile Cys Leu Pro Gly Lys Lys Ile Asn Lys Glu
         195                 200                 205            
 Arg Leu Ser Ala Phe Leu Cys Ala Asn Ala Asp Gly Thr His Lys Leu
     210                 215                 220                
 Lys Ser Ile Ile Ile Gly Lys Ser Lys Leu Pro Lys Ser Val Lys Glu
 225                 230                 235                 240
 Asp Thr Ser Thr Leu Pro Val Ile Tyr Lys Pro Ser Lys Asp Val Trp
                 245                 250                 255    
 Phe Thr Arg Glu Leu Phe Ser Glu Trp Phe Phe Gln Asn Phe Val Pro
             260                 265                 270        
 Glu Val Arg His Phe Gln Leu Asn Val Leu Arg Phe His Asp Glu Asp
         275                 280                 285            
 Val Arg Ala Leu Leu Leu Leu Asp Ser Cys Pro Ala His Pro Ser Ser
     290                 295                 300                
 Glu Ser Leu Thr Ser Glu Asp Gly Arg Ile Lys Cys Met Phe Phe Pro
 305                 310                 315                 320
 His Asn Thr Ser Thr Leu Ile Gln Pro Met Asn Gln Gly Val Ile Leu
                 325                 330                 335    
 Ser Cys Lys Arg Leu Tyr Arg Trp Lys Gln Leu Glu Glu Ser Leu Val
             340                 345                 350        
 Ile Phe Glu Glu Ser Asp Asp Glu Gln Glu Lys Gly Asp Lys Gly Val
         355                 360                 365            
 Ser Lys Ile Lys Ile Tyr Asn Ile Lys Ser Ala Ile Phe Asn Trp Ala
     370                 375                 380                
 Lys Ser Trp Glu Glu Val Lys Gln Ile Thr Ile Ala Asn Ala Trp Glu
 385                 390                 395                 400
 Asn Leu Leu Tyr Lys Lys Glu Pro Glu Tyr Asp Phe Gln Gly Leu Glu
                 405                 410                 415    
 His Gly Asp Tyr Arg Glu Ile Leu Glu Lys Cys Gly Glu Leu Glu Thr
             420                 425                 430        
 Lys Leu Asp Asp Asp Arg Val Trp Leu Asn Gly Asp Glu Glu Lys Gly
         435                 440                 445            
 Cys Leu Leu Lys Thr Lys Gly Gly Ile Thr Lys Glu Val Val Gln Lys
     450                 455                 460                
 Gly Gly Glu Ala Glu Lys Gln Thr Ala Glu Phe Lys Leu Ser Ala Val
 465                 470                 475                 480
 Arg Glu Ser Leu Asp Tyr Leu Leu Asp Phe Val Asp Ala Thr Pro Glu
                 485                 490                 495    
 Phe Gln Arg Phe His Phe Thr Leu Lys Glu Met Gln Gln Glu Ile Val
             500                 505                 510        
 Lys Lys Gln Phe Gln Ser Lys Ile His Ser Arg Ile Gly Ser Phe Leu
         515                 520                 525            
 Lys Pro Arg Pro His Asn Ile Lys Asp Ser Phe Ser Gly Pro Ser Thr
     530                 535                 540                
 Ser Gly Ser Asn His
 545                



      <210> 290
      <211> 299
      <212> PRT
      <213> Homo sapiens


      <400> 290
 Met Gly His Val Ser Ser Asp Asp Gly His Ser Asp Glu Asp Glu Leu
   1               5                  10                  15    
 Arg Lys Ser Leu Ser Glu Leu Val Asp Asp Lys Phe Gly Thr Gly Thr
              20                  25                  30        
 Lys Lys Val Thr Arg Ile Leu Asp Gly Gly Asn Pro Phe Leu Asp Val
          35                  40                  45            
 Pro Gln Ala Leu Ser Ala Thr Thr Tyr Lys His Gly Val Leu Thr Arg
      50                  55                  60                
 Lys Thr His Ala Asp Met Asp Gly Lys Arg Thr Pro Arg Gly Arg Arg
  65                  70                  75                  80
 Gly Trp Lys Lys Phe Tyr Ala Val Leu Lys Gly Thr Ile Leu Tyr Leu
                  85                  90                  95    
 Gln Lys Val Arg Asp Cys Pro Arg Asp Leu Thr His Pro Gly Ala Ser
             100                 105                 110        
 Asp Tyr Ser Lys Lys Ser Asn Val Leu Lys Leu Lys Thr Ala Asp Trp
         115                 120                 125            
 Arg Val Phe Leu Phe Gln Ala Pro Ser Lys Glu Glu Met Leu Ser Trp
     130                 135                 140                
 Ile Leu Arg Ile Asn Leu Val Ala Ala Ile Phe Ser Ala Pro Ala Phe
 145                 150                 155                 160
 Pro Ala Ala Val Ser Ser Met Lys Lys Phe Cys Arg Pro Leu Leu Pro
                 165                 170                 175    
 Ser Cys Thr Thr Arg Leu Cys Gln Glu Glu Gln Leu Arg Ser His Glu
             180                 185                 190        
 Asn Lys Leu Arg Gln Leu Thr Ala Glu Leu Ala Glu His Arg Cys His
         195                 200                 205            
 Pro Val Glu Arg Gly Ile Lys Ser Lys Glu Ala Glu Glu Tyr Arg Leu
     210                 215                 220                
 Lys Glu His Tyr Leu Thr Phe Glu Lys Ser Arg Tyr Glu Thr Tyr Ile
 225                 230                 235                 240
 His Leu Leu Ala Met Lys Ile Lys Val Gly Ser Asp Asp Leu Glu Arg
                 245                 250                 255    
 Ile Glu Ala Arg Leu Ala Thr Leu Glu Gly Asp Asp Pro Ser Leu Arg
             260                 265                 270        
 Lys Thr His Ser Ser Pro Ala Leu Ser Gln Gly His Val Thr Gly Ser
         275                 280                 285            
 Lys Thr Thr Lys Asp Ala Thr Gly Pro Asp Thr
     290                 295                



      <210> 291
      <211> 213
      <212> PRT
      <213> Homo sapiens


      <400> 291
 Met Glu Ala Ile Trp Leu Tyr Gln Phe Arg Leu Ile Val Ile Gly Asp
   1               5                  10                  15    
 Ser Thr Val Gly Lys Ser Cys Leu Ile Arg Arg Phe Thr Glu Gly Arg
              20                  25                  30        
 Phe Ala Gln Val Ser Asp Pro Thr Val Gly Val Asp Phe Phe Ser Arg
          35                  40                  45            
 Leu Val Glu Ile Glu Pro Gly Lys Arg Ile Lys Leu Gln Ile Trp Asp
      50                  55                  60                
 Thr Ala Gly Gln Glu Arg Phe Arg Ser Ile Thr Arg Ala Tyr Tyr Arg
  65                  70                  75                  80
 Asn Ser Val Gly Gly Leu Leu Leu Phe Asp Ile Thr Asn Arg Arg Ser
                  85                  90                  95    
 Phe Gln Asn Val His Glu Trp Leu Glu Glu Thr Lys Val His Val Gln
             100                 105                 110        
 Pro Tyr Gln Ile Val Phe Val Leu Val Gly His Lys Cys Asp Leu Asp
         115                 120                 125            
 Thr Gln Arg Gln Val Thr Arg His Glu Ala Glu Lys Leu Ala Ala Ala
     130                 135                 140                
 Tyr Gly Met Lys Tyr Ile Glu Thr Ser Ala Arg Asp Ala Ile Asn Val
 145                 150                 155                 160
 Glu Lys Ala Phe Thr Asp Leu Thr Arg Asp Ile Tyr Glu Leu Val Lys
                 165                 170                 175    
 Arg Gly Glu Ile Thr Ile Gln Glu Gly Trp Glu Gly Val Lys Ser Gly
             180                 185                 190        
 Phe Val Pro Asn Val Val His Ser Ser Glu Glu Val Val Lys Ser Glu
         195                 200                 205            
 Arg Arg Cys Leu Cys
     210            



      <210> 292
      <211> 142
      <212> PRT
      <213> Homo sapiens


      <400> 292
 Met Ala Thr Lys Ile Asp Lys Glu Ala Cys Arg Ala Ala Tyr Asn Leu
   1               5                  10                  15    
 Val Arg Asp Asp Gly Ser Ala Val Ile Trp Val Thr Phe Lys Tyr Asp
              20                  25                  30        
 Gly Ser Thr Ile Val Pro Gly Glu Gln Gly Ala Glu Tyr Gln His Phe
          35                  40                  45            
 Ile Gln Gln Cys Thr Asp Asp Val Arg Leu Phe Ala Phe Val Arg Phe
      50                  55                  60                
 Thr Thr Gly Asp Ala Met Ser Lys Arg Ser Lys Phe Ala Leu Ile Thr
  65                  70                  75                  80
 Trp Ile Gly Glu Asn Val Ser Gly Leu Gln Arg Ala Lys Thr Gly Thr
                  85                  90                  95    
 Asp Lys Thr Leu Val Lys Glu Val Val Gln Asn Phe Ala Lys Glu Phe
             100                 105                 110        
 Val Ile Ser Asp Arg Lys Glu Leu Glu Glu Asp Phe Ile Lys Ser Glu
         115                 120                 125            
 Leu Lys Lys Ala Gly Gly Ala Asn Tyr Asp Ala Gln Thr Glu
     130                 135                 140        



      <210> 293
      <211> 442
      <212> PRT
      <213> Homo sapiens


      <400> 293
 Met Lys Glu Glu Lys Glu His Arg Pro Lys Glu Lys Arg Val Thr Leu
   1               5                  10                  15    
 Leu Thr Pro Ala Gly Ala Thr Gly Ser Gly Gly Gly Thr Ser Gly Asp
              20                  25                  30        
 Ser Ser Lys Gly Glu Asp Lys Gln Asp Arg Asn Lys Glu Lys Lys Glu
          35                  40                  45            
 Ala Leu Ser Lys Val Pro Gly Arg Pro Leu Ala Arg Glu Arg Ala Gly
      50                  55                  60                
 Arg Val Arg Ser Ala Gly Arg Met Ala Gly Asn Gly Ala Ala Pro Phe
  65                  70                  75                  80
 Leu Ser Gln Val Leu Leu Leu Ser Leu Arg Leu Asn Gly Ser Arg Ile
                  85                  90                  95    
 Ile Leu Val His Pro Phe Thr Arg Asn Gly Glu Ser Pro Ser Arg Pro
             100                 105                 110        
 Asn Pro Gly Trp Gly Leu Tyr Pro His Met Tyr Ala Arg Ala Tyr Ile
         115                 120                 125            
 Asn Phe Lys Asn Gln Glu Asp Ile Ile Leu Phe Arg Asp Arg Phe Asp
     130                 135                 140                
 Gly Tyr Val Phe Leu Asp Asn Lys Ala Lys Lys Thr Thr Pro Leu Leu
 145                 150                 155                 160
 Ser Phe Leu Lys Asn Lys Gln Arg Met Arg Glu Glu Lys Arg Glu Glu
                 165                 170                 175    
 Arg Arg Arg Arg Glu Ile Glu Arg Lys Arg Gln Arg Glu Glu Glu Arg
             180                 185                 190        
 Arg Lys Trp Lys Glu Glu Glu Lys Arg Lys Arg Lys Asp Ile Glu Lys
         195                 200                 205            
 Leu Lys Lys Ile Asp Arg Ile Pro Glu Arg Asp Lys Leu Lys Asp Glu
     210                 215                 220                
 Pro Lys Ile Lys Val His Arg Phe Leu Leu Gln Ala Val Asn Gln Lys
 225                 230                 235                 240
 Asn Leu Leu Lys Lys Pro Glu Lys Gly Asp Glu Lys Glu Leu Asp Lys
                 245                 250                 255    
 Arg Glu Lys Ala Lys Lys Leu Asp Lys Glu Asn Leu Ser Asp Glu Arg
             260                 265                 270        
 Ala Ser Gly Gln Ser Cys Thr Leu Pro Lys Arg Ser Asp Ser Glu Leu
         275                 280                 285            
 Lys Asp Glu Lys Pro Lys Arg Pro Glu Asp Glu Ser Gly Arg Asp Tyr
     290                 295                 300                
 Arg Glu Arg Glu Arg Glu Tyr Glu Arg Asp Gln Glu Arg Ile Leu Arg
 305                 310                 315                 320
 Glu Arg Glu Arg Leu Lys Arg Gln Glu Glu Glu Arg Arg Arg Gln Lys
                 325                 330                 335    
 Glu Arg Tyr Glu Lys Glu Lys Thr Phe Lys Arg Lys Glu Glu Glu Met
             340                 345                 350        
 Lys Lys Glu Lys Asp Thr Leu Arg Asp Lys Gly Lys Lys Ala Glu Ser
         355                 360                 365            
 Thr Glu Ser Ile Gly Ser Ser Glu Lys Thr Glu Lys Lys Glu Glu Val
     370                 375                 380                
 Val Lys Arg Asp Arg Ile Arg Asn Lys Asp Arg Pro Ala Met Gln Leu
 385                 390                 395                 400
 Tyr Gln Pro Gly Ala Arg Ser Arg Asn Arg Leu Cys Pro Pro Asp Asp
                 405                 410                 415    
 Ser Thr Lys Ser Gly Asp Ser Ala Ala Glu Arg Lys Gln Glu Ser Gly
             420                 425                 430        
 Ile Ser His Arg Lys Glu Gly Gly Glu Glu
         435                 440        



      <210> 294
      <211> 276
      <212> PRT
      <213> Homo sapiens


      <400> 294
 Met Asp His Leu Cys Val Cys Glu Glu Gly Gly Asn Lys Leu Trp Tyr
   1               5                  10                  15    
 Lys Lys Pro Gly Asn Phe Gln Gly Thr Leu Asp Ala Phe Phe Lys Ile
              20                  25                  30        
 Ile Arg Asn Glu Gly Ile Lys Ser Leu Trp Ser Gly Leu Pro Pro Thr
          35                  40                  45            
 Leu Val Met Ala Val Pro Ala Thr Val Ile Tyr Phe Thr Cys Tyr Asp
      50                  55                  60                
 Gln Leu Ser Ala Leu Leu Arg Ser Lys Leu Gly Glu Asn Glu Thr Cys
  65                  70                  75                  80
 Ile Pro Ile Val Ala Gly Ile Val Ala Arg Phe Gly Ala Val Thr Val
                  85                  90                  95    
 Ile Ser Pro Leu Glu Leu Ile Arg Thr Lys Met Gln Ser Lys Lys Phe
             100                 105                 110        
 Ser Tyr Val Glu Leu His Arg Phe Val Ser Lys Lys Val Ser Glu Asp
         115                 120                 125            
 Gly Trp Ile Ser Leu Trp Arg Gly Trp Ala Pro Thr Val Leu Arg Asp
     130                 135                 140                
 Val Pro Phe Ser Ala Met Tyr Trp Tyr Asn Tyr Glu Ile Leu Lys Lys
 145                 150                 155                 160
 Trp Leu Cys Glu Lys Ser Gly Leu Tyr Glu Pro Thr Phe Met Ile Asn
                 165                 170                 175    
 Phe Thr Ser Gly Ala Leu Ser Gly Ser Phe Ala Ala Val Ala Thr Leu
             180                 185                 190        
 Pro Phe Asp Val Val Lys Thr Gln Lys Gln Thr Gln Leu Trp Thr Tyr
         195                 200                 205            
 Glu Ser His Lys Ile Ser Met Pro Leu His Met Ser Thr Trp Ile Ile
     210                 215                 220                
 Met Lys Asn Ile Val Ala Lys Asn Gly Phe Ser Gly Leu Phe Ser Gly
 225                 230                 235                 240
 Leu Ile Pro Arg Leu Ile Lys Ile Ala Pro Ala Cys Ala Ile Met Ile
                 245                 250                 255    
 Ser Thr Tyr Glu Phe Gly Lys Ala Phe Phe Gln Lys Gln Asn Val Arg
             260                 265                 270        
 Arg Gln Gln Tyr
         275    



      <210> 295
      <211> 975
      <212> PRT
      <213> Homo sapiens


      <400> 295
 Met Ser Gly Ile Gly Asn Lys Arg Ala Ala Gly Glu Pro Val Thr Ser
   1               5                  10                  15    
 Met Pro Pro Glu Lys Lys Ala Ala Val Glu Asp Ser Gly Thr Thr Val
              20                  25                  30        
 Glu Thr Ile Lys Leu Gly Gly Val Ser Ser Thr Glu Glu Leu Asp Ile
          35                  40                  45            
 Arg Thr Leu Gln Thr Lys Asn Arg Lys Leu Ala Glu Met Leu Asp Gln
      50                  55                  60                
 Arg Gln Ala Ile Glu Asp Glu Leu Arg Glu His Ile Glu Lys Leu Glu
  65                  70                  75                  80
 Arg Arg Gln Ala Thr Asp Asp Ala Ser Leu Leu Ile Val Asn Arg Tyr
                  85                  90                  95    
 Trp Ser Gln Phe Asp Glu Asn Ile Arg Ile Ile Leu Lys Arg Tyr Asp
             100                 105                 110        
 Leu Glu Gln Gly Leu Gly Asp Leu Leu Thr Glu Arg Lys Ala Leu Val
         115                 120                 125            
 Val Pro Glu Pro Glu Pro Asp Ser Asp Ser Asn Gln Glu Arg Lys Asp
     130                 135                 140                
 Asp Arg Glu Arg Gly Glu Gly Gln Glu Pro Ala Phe Ser Phe Leu Ala
 145                 150                 155                 160
 Thr Leu Ala Ser Ser Ser Ser Glu Glu Met Glu Ser Gln Leu Gln Glu
                 165                 170                 175    
 Arg Val Glu Ser Ser Arg Arg Ala Val Ser Gln Ile Val Thr Val Tyr
             180                 185                 190        
 Asp Lys Leu Gln Glu Lys Val Glu Leu Leu Ser Arg Lys Leu Asn Ser
         195                 200                 205            
 Gly Asp Asn Leu Ile Val Glu Glu Ala Val Gln Glu Leu Asn Ser Phe
     210                 215                 220                
 Leu Ala Gln Glu Asn Met Arg Leu Gln Glu Leu Thr Asp Leu Leu Gln
 225                 230                 235                 240
 Glu Lys His Arg Thr Met Ser Gln Glu Phe Ser Lys Leu Gln Ser Lys
                 245                 250                 255    
 Val Glu Thr Ala Glu Ser Arg Val Ser Val Leu Glu Ser Met Ile Asp
             260                 265                 270        
 Asp Leu Gln Trp Asp Ile Asp Lys Ile Arg Lys Arg Glu Gln Arg Leu
         275                 280                 285            
 Asn Arg His Leu Ala Glu Val Leu Glu Arg Val Asn Ser Lys Gly Tyr
     290                 295                 300                
 Lys Val Tyr Gly Ala Gly Ser Ser Leu Tyr Gly Gly Thr Ile Thr Ile
 305                 310                 315                 320
 Asn Ala Arg Lys Phe Glu Glu Met Asn Ala Glu Leu Glu Glu Asn Lys
                 325                 330                 335    
 Glu Leu Ala Gln Asn Arg Leu Cys Glu Leu Glu Lys Leu Arg Gln Asp
             340                 345                 350        
 Phe Glu Glu Val Thr Thr Gln Asn Glu Lys Leu Lys Val Glu Leu Arg
         355                 360                 365            
 Ser Ala Val Glu Gln Val Val Lys Glu Thr Pro Glu Tyr Arg Cys Met
     370                 375                 380                
 Gln Ser Gln Phe Ser Val Leu Tyr Asn Glu Ser Leu Gln Leu Lys Ala
 385                 390                 395                 400
 His Leu Asp Glu Ala Arg Thr Leu Leu His Gly Thr Arg Gly Thr His
                 405                 410                 415    
 Gln His Gln Val Glu Leu Ile Glu Arg Asp Glu Val Ser Leu His Lys
             420                 425                 430        
 Lys Leu Arg Thr Glu Val Ile Gln Leu Glu Asp Thr Leu Ala Gln Val
         435                 440                 445            
 Arg Lys Glu Tyr Glu Met Leu Arg Ile Glu Phe Glu Gln Thr Leu Ala
     450                 455                 460                
 Ala Asn Glu Gln Ala Gly Pro Ile Asn Arg Glu Met Arg His Leu Ile
 465                 470                 475                 480
 Ser Ser Leu Gln Asn His Asn His Gln Leu Lys Gly Glu Val Leu Arg
                 485                 490                 495    
 Tyr Lys Arg Lys Leu Arg Glu Ala Gln Ser Asp Leu Asn Lys Thr Arg
             500                 505                 510        
 Leu Arg Ser Gly Ser Ala Leu Leu Gln Ser Gln Ser Ser Thr Glu Asp
         515                 520                 525            
 Pro Lys Asp Glu Pro Ala Glu Leu Lys Pro Asp Ser Glu Asp Leu Ser
     530                 535                 540                
 Ser Gln Ser Ser Ala Ser Lys Ala Ser Gln Glu Asp Ala Asn Glu Ile
 545                 550                 555                 560
 Lys Ser Lys Arg Asp Glu Glu Glu Arg Glu Arg Glu Arg Arg Glu Lys
                 565                 570                 575    
 Glu Arg Glu Arg Glu Arg Glu Arg Glu Lys Glu Lys Glu Arg Glu Arg
             580                 585                 590        
 Glu Lys Gln Lys Leu Lys Glu Ser Glu Lys Glu Arg Asp Ser Ala Lys
         595                 600                 605            
 Asp Lys Glu Lys Gly Lys His Asp Asp Gly Arg Lys Lys Glu Ala Glu
     610                 615                 620                
 Ile Ile Lys Gln Leu Lys Ile Glu Leu Lys Lys Ala Gln Glu Ser Gln
 625                 630                 635                 640
 Lys Glu Met Lys Leu Leu Leu Asp Met Tyr Arg Ser Ala Pro Lys Glu
                 645                 650                 655    
 Gln Arg Asp Lys Val Gln Leu Met Ala Ala Glu Lys Lys Ser Lys Ala
             660                 665                 670        
 Glu Leu Glu Asp Leu Arg Gln Arg Leu Lys Asp Leu Glu Asp Lys Glu
         675                 680                 685            
 Lys Lys Glu Asn Lys Lys Met Ala Asp Glu Asp Ala Leu Arg Lys Ile
     690                 695                 700                
 Arg Ala Val Glu Glu Gln Ile Glu Tyr Leu Gln Lys Lys Leu Ala Met
 705                 710                 715                 720
 Ala Lys Gln Glu Glu Glu Ala Leu Leu Ser Glu Met Asp Val Thr Gly
                 725                 730                 735    
 Gln Ala Phe Glu Asp Met Gln Glu Gln Asn Ile Arg Leu Met Gln Gln
             740                 745                 750        
 Leu Arg Glu Lys Asp Asp Ala Asn Phe Lys Leu Met Ser Glu Arg Ile
         755                 760                 765            
 Lys Ser Asn Gln Ile His Lys Leu Leu Lys Glu Glu Lys Glu Glu Leu
     770                 775                 780                
 Ala Asp Gln Val Leu Thr Leu Lys Thr Gln Val Asp Ala Gln Leu Gln
 785                 790                 795                 800
 Val Val Arg Lys Leu Glu Glu Lys Glu His Leu Leu Gln Ser Asn Ile
                 805                 810                 815    
 Gly Thr Gly Glu Lys Glu Leu Gly Leu Arg Thr Gln Ala Leu Glu Met
             820                 825                 830        
 Asn Lys Arg Lys Ala Met Glu Ala Ala Gln Leu Ala Asp Asp Leu Lys
         835                 840                 845            
 Ala Gln Leu Glu Leu Ala Gln Lys Lys Leu His Asp Phe Gln Asp Glu
     850                 855                 860                
 Ile Val Glu Asn Ser Val Thr Lys Glu Lys Asp Met Phe Asn Phe Lys
 865                 870                 875                 880
 Arg Ala Gln Glu Asp Ile Ser Arg Leu Arg Arg Lys Leu Glu Thr Thr
                 885                 890                 895    
 Lys Lys Pro Asp Asn Val Pro Lys Cys Asp Glu Ile Leu Met Glu Glu
             900                 905                 910        
 Ile Lys Asp Tyr Lys Ala Arg Leu Thr Cys Pro Cys Cys Asn Met Arg
         915                 920                 925            
 Lys Lys Asp Ala Val Leu Thr Lys Cys Phe His Val Phe Cys Phe Glu
     930                 935                 940                
 Cys Val Lys Thr Arg Tyr Asp Thr Arg Gln Arg Lys Cys Pro Lys Cys
 945                 950                 955                 960
 Asn Ala Ala Phe Gly Ala Asn Asp Phe His Arg Ile Tyr Ile Gly
                 965                 970                 975



      <210> 296
      <211> 91
      <212> PRT
      <213> Homo sapiens


      <400> 296
 Met Arg Ser Leu Leu Ser Val Gly Leu Pro Pro Ile Pro Ile Gly Arg
   1               5                  10                  15    
 Gly Cys His Phe Thr Leu Ile Thr Val Phe Leu Tyr Cys Thr Arg Val
              20                  25                  30        
 Gly Arg Lys Gly Thr Cys Val Ala Pro Pro Asp Leu Pro Val Ser Ala
          35                  40                  45            
 Ser Thr Phe Gly Thr Ser Cys Leu Arg Gln Glu Ala Ala Ala Glu Gly
      50                  55                  60                
 Arg Pro Val Val Arg Phe Asp Lys Ile Lys Ala Ala Gly Lys Trp Thr
  65                  70                  75                  80
 Val Arg Phe Arg Glu Val Glu Gly Ser Trp Ile
                  85                  90    



      <210> 297
      <211> 134
      <212> PRT
      <213> Homo sapiens


      <400> 297
 Met Val Glu Asn Ser Pro Ser Pro Leu Pro Glu Arg Ala Ile Tyr Gly
   1               5                  10                  15    
 Phe Val Leu Phe Leu Ser Ser Gln Phe Gly Phe Ile Leu Tyr Leu Val
              20                  25                  30        
 Trp Ala Phe Ile Pro Glu Ser Trp Leu Asn Ser Leu Gly Leu Thr Tyr
          35                  40                  45            
 Trp Pro Gln Lys Tyr Trp Ala Val Ala Leu Pro Val Tyr Leu Leu Ile
      50                  55                  60                
 Ala Ile Val Ile Gly Tyr Val Leu Leu Phe Gly Ile Asn Met Met Ser
  65                  70                  75                  80
 Thr Ser Pro Leu Asp Ser Ile His Thr Ile Thr Asp Asn Tyr Ala Lys
                  85                  90                  95    
 Asn Gln Gln Gln Lys Lys Tyr Gln Glu Glu Ala Ile Pro Ala Leu Arg
             100                 105                 110        
 Asp Ile Ser Ile Ser Glu Val Asn Gln Met Phe Phe Leu Ala Ala Lys
         115                 120                 125            
 Glu Leu Tyr Thr Lys Asn
     130                



      <210> 298
      <211> 453
      <212> PRT
      <213> Homo sapiens


      <400> 298
 Met Glu Asp Tyr Leu Gln Gly Cys Arg Ala Ala Leu Gln Glu Ser Arg
   1               5                  10                  15    
 Pro Leu His Val Val Leu Gly Asn Glu Ala Cys Asp Leu Asp Ser Thr
              20                  25                  30        
 Val Ser Ala Leu Ala Leu Ala Phe Tyr Leu Ala Lys Thr Thr Glu Ala
          35                  40                  45            
 Glu Glu Val Phe Val Pro Val Leu Asn Ile Lys Arg Ser Glu Leu Pro
      50                  55                  60                
 Leu Arg Gly Asp Ile Val Phe Phe Leu Gln Lys Val His Ile Pro Glu
  65                  70                  75                  80
 Ser Ile Leu Ile Phe Arg Asp Glu Ile Asp Leu His Ala Leu Tyr Gln
                  85                  90                  95    
 Ala Gly Gln Leu Thr Leu Ile Leu Val Asp His His Ile Leu Ser Lys
             100                 105                 110        
 Ser Asp Thr Ala Leu Glu Glu Ala Val Ala Glu Val Leu Asp His Arg
         115                 120                 125            
 Pro Ile Glu Pro Lys His Cys Pro Pro Cys His Val Ser Val Glu Leu
     130                 135                 140                
 Val Gly Ser Cys Ala Thr Leu Val Thr Glu Arg Ile Leu Gln Gly Ala
 145                 150                 155                 160
 Pro Glu Ile Leu Asp Arg Gln Thr Ala Ala Leu Leu His Gly Thr Ile
                 165                 170                 175    
 Ile Leu Asp Cys Val Asn Met Asp Leu Lys Ile Gly Lys Ala Thr Pro
             180                 185                 190        
 Lys Asp Ser Lys Tyr Val Glu Lys Leu Glu Ala Leu Phe Pro Asp Leu
         195                 200                 205            
 Pro Lys Arg Asn Asp Ile Phe Asp Ser Leu Gln Lys Ala Lys Phe Asp
     210                 215                 220                
 Val Ser Gly Leu Thr Thr Glu Gln Met Leu Arg Lys Asp Gln Lys Thr
 225                 230                 235                 240
 Ile Tyr Arg Gln Gly Val Lys Val Ala Ile Ser Ala Ile Tyr Met Asp
                 245                 250                 255    
 Leu Glu Ala Phe Leu Gln Arg Ser Asn Leu Leu Ala Asp Leu His Ala
             260                 265                 270        
 Phe Cys Gln Ala His Ser Tyr Asp Val Leu Val Ala Met Thr Ile Phe
         275                 280                 285            
 Phe Asn Thr His Asn Glu Pro Val Arg Gln Leu Ala Ile Phe Cys Pro
     290                 295                 300                
 His Val Ala Leu Gln Thr Thr Ile Cys Glu Val Leu Glu Arg Ser His
 305                 310                 315                 320
 Ser Pro Pro Leu Lys Leu Thr Pro Ala Ser Ser Thr His Pro Asn Leu
                 325                 330                 335    
 His Ala Tyr Leu Gln Gly Asn Thr Gln Val Ser Arg Lys Lys Leu Leu
             340                 345                 350        
 Pro Leu Leu Gln Glu Ala Leu Ser Ala Tyr Phe Asp Ser Met Lys Ile
         355                 360                 365            
 Pro Ser Gly Gln Pro Glu Thr Ala Asp Val Ser Arg Glu Gln Val Asp
     370                 375                 380                
 Lys Glu Leu Asp Arg Ala Ser Asn Ser Leu Ile Ser Gly Leu Ser Gln
 385                 390                 395                 400
 Asp Glu Glu Asp Pro Pro Leu Pro Pro Thr Pro Met Asn Ser Leu Val
                 405                 410                 415    
 Asp Glu Cys Pro Leu Asp Gln Gly Leu Pro Lys Leu Ser Ala Glu Ala
             420                 425                 430        
 Val Phe Glu Lys Cys Ser Gln Ile Ser Leu Ser Gln Ser Thr Thr Ala
         435                 440                 445            
 Ser Leu Ser Lys Lys
     450            



      <210> 299
      <211> 125
      <212> PRT
      <213> Homo sapiens


      <400> 299
 Met Asp Asp Val Glu Ser Ser Glu Glu Glu Glu Glu Glu Asp Glu Lys
   1               5                  10                  15    
 Leu Glu Arg Val Pro Ser Pro Asp His Arg Arg Arg Ser Tyr Arg Asp
              20                  25                  30        
 Leu Asp Lys Pro Arg Arg Ser Pro Thr Leu Arg Tyr Arg Arg Ser Arg
          35                  40                  45            
 Ser Arg Ser Pro Arg Arg Arg Ser Arg Ser Pro Lys Arg Arg Ser Pro
      50                  55                  60                
 Ser Pro Arg Arg Glu Arg His Arg Ser Lys Ser Pro Arg Arg His Arg
  65                  70                  75                  80
 Ser Arg Ser Arg Asp Arg Arg His Arg Ser Arg Ser Lys Ser Pro Gly
                  85                  90                  95    
 His His Arg Ser His Arg His Arg Ser His Ser Lys Ser Pro Glu Arg
             100                 105                 110        
 Ser Lys Lys Ser His Lys Lys Ser Arg Arg Gly Asn Glu
         115                 120                 125



      <210> 300
      <211> 274
      <212> PRT
      <213> Homo sapiens


      <400> 300
 Met Pro Arg Ala Glu Pro Arg Ala Thr Leu Gly Glu Gln Glu Lys Ala
   1               5                  10                  15    
 Gly Leu Pro Leu Gly Ala Trp Arg Leu Tyr Leu Leu Arg His Phe Arg
              20                  25                  30        
 Lys Gln Thr Glu Leu Arg Arg Ser Gly Ser Arg Asp Val Thr Gly Ala
          35                  40                  45            
 Leu Leu Val Ala Ala Ala Val Ala Ser Glu Ala Val Gly Ser Leu Arg
      50                  55                  60                
 Val Ala Glu Gly Gly Pro Asn Thr Leu Leu Leu Gln Val Leu Arg Ser
  65                  70                  75                  80
 Trp Pro Trp Cys Asn Lys Glu Leu Lys Thr Met Glu Glu Arg Lys Val
                  85                  90                  95    
 Lys Arg Arg Ser Pro Lys Ser Phe Ser Ala His Cys Thr Gln Val Val
             100                 105                 110        
 Asn Ala Lys Lys Asn Ala Ile Pro Val Ser Lys Ser Thr Gly Phe Ser
         115                 120                 125            
 Asn Pro Ala Ser Gln Ser Thr Ser Gln Arg Pro Lys Leu Lys Arg Val
     130                 135                 140                
 Met Lys Glu Lys Thr Lys Pro Gln Gly Gly Glu Gly Lys Gly Ala Gln
 145                 150                 155                 160
 Ser Thr Pro Ile Gln His Ser Phe Leu Thr Asp Val Ser Asp Val Gln
                 165                 170                 175    
 Glu Met Glu Arg Gly Leu Leu Ser Leu Leu Asn Asp Phe His Ser Gly
             180                 185                 190        
 Lys Leu Gln Ala Phe Gly Asn Glu Cys Ser Ile Glu Gln Met Glu His
         195                 200                 205            
 Val Arg Gly Met Gln Glu Lys Leu Ala Arg Leu Asn Leu Glu Leu Tyr
     210                 215                 220                
 Gly Glu Leu Glu Glu Leu Pro Glu Asp Lys Arg Lys Thr Ala Ser Asp
 225                 230                 235                 240
 Ser Asn Leu Asp Arg Leu Leu Ser Asp Leu Glu Glu Leu Asn Ser Ser
                 245                 250                 255    
 Ile Gln Lys Leu His Leu Ala Asp Ala Gln Asp Val Pro Asn Thr Ser
             260                 265                 270        
 Ala Ser
        



      <210> 301
      <211> 290
      <212> PRT
      <213> Homo sapiens


      <400> 301
 Met Ser Asn Lys Glu Gly Ser Gly Gly Phe Arg Lys Arg Lys His Asp
   1               5                  10                  15    
 Asn Phe Pro His Asn Gln Arg Arg Glu Gly Lys Asp Val Asn Ser Ser
              20                  25                  30        
 Ser Pro Val Met Leu Ala Phe Lys Ser Phe Gln Gln Glu Leu Asp Ala
          35                  40                  45            
 Arg His Asp Lys Tyr Glu Arg Leu Val Lys Leu Ser Arg Asp Ile Thr
      50                  55                  60                
 Val Glu Ser Lys Arg Thr Ile Phe Leu Leu His Arg Ile Thr Ser Ala
  65                  70                  75                  80
 Pro Asp Met Glu Asp Ile Leu Thr Glu Ser Glu Ile Lys Leu Asp Gly
                  85                  90                  95    
 Val Arg Gln Lys Ile Phe Gln Val Ala Gln Glu Leu Ser Gly Glu Asp
             100                 105                 110        
 Met His Gln Phe His Arg Ala Ile Thr Thr Gly Leu Gln Glu Tyr Val
         115                 120                 125            
 Glu Ala Val Ser Phe Gln His Phe Ile Lys Thr Arg Ser Leu Ile Ser
     130                 135                 140                
 Met Asp Glu Ile Asn Lys Gln Leu Ile Phe Thr Thr Glu Asp Asn Gly
 145                 150                 155                 160
 Lys Glu Asn Lys Thr Pro Ser Ser Asp Ala Gln Asp Lys Gln Phe Gly
                 165                 170                 175    
 Thr Trp Arg Leu Arg Val Thr Pro Val Asp Tyr Leu Leu Gly Val Ala
             180                 185                 190        
 Asp Leu Thr Gly Glu Leu Met Arg Met Cys Ile Asn Ser Val Gly Asn
         195                 200                 205            
 Gly Asp Ile Asp Thr Pro Phe Glu Val Ser Gln Phe Leu Arg Gln Val
     210                 215                 220                
 Tyr Asp Gly Phe Ser Phe Ile Gly Asn Thr Gly Pro Tyr Glu Val Ser
 225                 230                 235                 240
 Lys Lys Leu Tyr Thr Leu Lys Gln Ser Leu Ala Lys Val Glu Asn Ala
                 245                 250                 255    
 Cys Tyr Ala Leu Lys Val Arg Gly Ser Glu Ile Pro Lys His Met Leu
             260                 265                 270        
 Ala Asp Val Phe Ser Val Lys Thr Glu Met Ile Asp Gln Glu Glu Gly
         275                 280                 285            
 Ile Ser
     290



      <210> 302
      <211> 208
      <212> PRT
      <213> Homo sapiens


      <400> 302
 Met Glu Ala Pro Pro Val Thr Met Met Pro Val Thr Gly Gly Thr Ile
   1               5                  10                  15    
 Asn Met Met Glu Tyr Leu Leu Gln Gly Ser Val Leu Asp His Ser Leu
              20                  25                  30        
 Glu Ser Leu Ile His Arg Leu Arg Gly Leu Cys Asp Asn Met Glu Pro
          35                  40                  45            
 Glu Thr Phe Leu Asp His Glu Met Val Phe Leu Leu Lys Gly Gln Gln
      50                  55                  60                
 Ala Ser Pro Phe Val Leu Arg Ala Arg Arg Ser Met Asp Arg Ala Gly
  65                  70                  75                  80
 Ala Pro Trp His Leu Arg Tyr Leu Gly Gln Pro Glu Met Gly Asp Lys
                  85                  90                  95    
 Asn Arg His Ala Leu Val Arg Asn Cys Val Asp Ile Ala Thr Ser Glu
             100                 105                 110        
 Asn Leu Thr Asp Phe Leu Met Glu Met Gly Phe Arg Met Asp His Glu
         115                 120                 125            
 Phe Val Ala Lys Gly His Leu Phe Arg Lys Gly Ile Met Lys Ile Met
     130                 135                 140                
 Val Tyr Lys Ile Phe Arg Ile Leu Val Pro Gly Asn Thr Asp Ser Thr
 145                 150                 155                 160
 Glu Ala Leu Ser Leu Ser Tyr Leu Val Glu Leu Ser Val Val Ala Pro
                 165                 170                 175    
 Ala Gly Gln Asp Met Val Ser Asp Asp Met Lys Asn Phe Ala Glu Gln
             180                 185                 190        
 Leu Lys Pro Leu Val His Leu Glu Lys Ile Asp Pro Lys Arg Leu Met
         195                 200                 205            





      <210> 303
      <211> 101
      <212> PRT
      <213> Homo sapiens


      <400> 303
 Met Val Cys Glu Lys Cys Glu Lys Lys Leu Gly Thr Val Ile Thr Pro
   1               5                  10                  15    
 Asp Thr Trp Lys Asp Gly Ala Arg Asn Thr Thr Glu Ser Gly Gly Arg
              20                  25                  30        
 Lys Leu Asn Glu Asn Lys Ala Leu Thr Ser Lys Lys Ala Arg Phe Asp
          35                  40                  45            
 Pro Tyr Gly Lys Asn Lys Phe Ser Thr Cys Arg Ile Cys Lys Ser Ser
      50                  55                  60                
 Val His Gln Pro Gly Ser His Tyr Cys Gln Gly Cys Ala Tyr Lys Lys
  65                  70                  75                  80
 Gly Ile Cys Ala Met Cys Gly Lys Lys Val Leu Asp Thr Lys Asn Tyr
                  85                  90                  95    
 Lys Gln Thr Ser Val
             100    



      <210> 304
      <211> 387
      <212> PRT
      <213> Homo sapiens


      <400> 304
 Met Ala Gly Ser Glu Pro Arg Ser Gly Thr Asn Ser Pro Pro Pro Pro
   1               5                  10                  15    
 Phe Ser Asp Trp Gly Arg Leu Glu Ala Ala Ile Leu Ser Gly Trp Lys
              20                  25                  30        
 Thr Phe Trp Gln Ser Val Ser Lys Glu Arg Val Ala Arg Thr Thr Ser
          35                  40                  45            
 Arg Glu Glu Val Asp Glu Ala Ala Ser Thr Leu Thr Arg Leu Pro Ile
      50                  55                  60                
 Asp Val Gln Leu Tyr Ile Leu Ser Phe Leu Ser Pro His Asp Leu Cys
  65                  70                  75                  80
 Gln Leu Gly Ser Thr Asn His Tyr Trp Asn Glu Thr Val Arg Asp Pro
                  85                  90                  95    
 Ile Leu Trp Arg Tyr Phe Leu Leu Arg Asp Leu Pro Ser Trp Ser Ser
             100                 105                 110        
 Val Asp Trp Lys Ser Leu Pro Asp Leu Glu Ile Leu Lys Lys Pro Ile
         115                 120                 125            
 Ser Glu Val Thr Asp Gly Ala Phe Phe Asp Tyr Met Ala Val Tyr Arg
     130                 135                 140                
 Met Cys Cys Pro Tyr Thr Arg Arg Ala Ser Lys Ser Ser Arg Pro Met
 145                 150                 155                 160
 Tyr Gly Ala Val Thr Ser Phe Leu His Ser Leu Ile Ile Gln Asn Glu
                 165                 170                 175    
 Pro Arg Phe Ala Met Phe Gly Pro Gly Leu Glu Glu Leu Asn Thr Ser
             180                 185                 190        
 Leu Val Leu Ser Leu Met Ser Ser Glu Glu Leu Cys Pro Thr Ala Gly
         195                 200                 205            
 Leu Pro Gln Arg Gln Ile Asp Gly Ile Gly Ser Gly Val Asn Phe Gln
     210                 215                 220                
 Leu Asn Asn Gln His Lys Phe Asn Ile Leu Ile Leu Tyr Ser Thr Thr
 225                 230                 235                 240
 Arg Lys Glu Arg Asp Arg Ala Arg Glu Glu His Thr Ser Ala Val Asn
                 245                 250                 255    
 Lys Met Phe Ser Arg His Asn Glu Gly Asp Asp Gln Gln Gly Ser Arg
             260                 265                 270        
 Tyr Ser Val Ile Pro Gln Ile Gln Lys Val Cys Glu Val Val Asp Gly
         275                 280                 285            
 Phe Ile Tyr Val Ala Asn Ala Glu Ala His Lys Arg His Glu Trp Gln
     290                 295                 300                
 Asp Glu Phe Ser His Ile Met Ala Met Thr Asp Pro Ala Phe Gly Ser
 305                 310                 315                 320
 Ser Gly Arg Pro Leu Leu Val Leu Ser Cys Ile Ser Gln Gly Asp Val
                 325                 330                 335    
 Lys Arg Met Pro Cys Phe Tyr Leu Ala His Glu Leu His Leu Asn Leu
             340                 345                 350        
 Leu Asn His Pro Trp Leu Val Gln Asp Thr Glu Ala Glu Thr Leu Thr
         355                 360                 365            
 Gly Phe Leu Asn Gly Ile Glu Trp Ile Leu Glu Glu Val Glu Ser Lys
     370                 375                 380                
 Arg Ala Arg
 385        



      <210> 305
      <211> 155
      <212> PRT
      <213> Homo sapiens


      <400> 305
 Met Leu Lys Ala Lys Ile Leu Phe Val Gly Pro Cys Glu Ser Gly Lys
   1               5                  10                  15    
 Thr Val Leu Ala Asn Phe Leu Thr Glu Ser Ser Asp Ile Thr Glu Tyr
              20                  25                  30        
 Ser Pro Thr Gln Gly Val Arg Phe Glu Ser Cys Trp Pro Ala Leu Met
          35                  40                  45            
 Lys Asp Ala His Gly Val Val Ile Val Phe Asn Ala Asp Ile Pro Ser
      50                  55                  60                
 His Arg Lys Glu Met Glu Met Trp Tyr Ser Cys Phe Val Gln Gln Pro
  65                  70                  75                  80
 Ser Leu Gln Asp Thr Gln Cys Met Leu Ile Ala His His Lys Pro Gly
                  85                  90                  95    
 Ser Gly Asp Asp Lys Gly Ser Leu Ser Leu Ser Pro Pro Leu Asn Lys
             100                 105                 110        
 Leu Lys Leu Val His Ser Asn Leu Glu Asp Asp Pro Glu Glu Ile Arg
         115                 120                 125            
 Met Glu Phe Ile Lys Tyr Leu Lys Ser Ile Ile Asn Ser Met Ser Glu
     130                 135                 140                
 Ser Arg Asp Arg Glu Glu Met Ser Ile Met Thr
 145                 150                 155



      <210> 306
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 306
 Met Cys Gln Thr Thr Ala Ala Gly Glu Gly Ala His Ala Ala Asp Glu
   1               5                  10                  15    
 Gly Tyr Thr Gln Arg Val Val Gly Ala Arg Arg Gly Thr Pro Gln Arg
              20                  25                  30        
 Tyr Thr Gly Gly Ala Glu Thr Lys Asn Arg Ala Phe Arg Ser Tyr Pro
          35                  40                  45            
 Lys Met Glu Thr Ser Trp Pro Arg Gly Gly Gly Ser Thr Pro Pro Val
      50                  55                  60                
 Ala Leu Asp Ala Gln Val Glu Arg Glu Cys Ala Leu Gly Ser Gly Ala
  65                  70                  75                  80
 Gln Gly Lys His Ser Cys Leu Ala Val Arg Val Val Leu Ile Phe Cys
                  85                  90                  95    
 Ile Asn Glu His Tyr Pro Gln Thr Leu Thr Tyr Arg Leu Pro Phe Val
             100                 105                 110        
 Leu Pro Leu Arg Ser Gly Gly Thr Pro Thr Ser Trp Arg Ala Leu Phe
         115                 120                 125            
 Phe Pro Ser Ser Ser Asp Ser Asn Cys Lys Leu Cys Gly Gly Thr Ser
     130                 135                 140                
 Ser
 145



      <210> 307
      <211> 167
      <212> PRT
      <213> Homo sapiens


      <400> 307
 Met Val Val Gly Arg Ser Ser Phe Pro Met Gln Tyr Phe Pro Ile Asn
   1               5                  10                  15    
 Asn Thr Ser Leu Pro Gln Glu Tyr Phe Leu Phe Gln Lys Met Gln Trp
              20                  25                  30        
 His Val Tyr Asn Pro Val Leu Gln Leu Pro Tyr Tyr Glu Met Thr Ala
          35                  40                  45            
 Pro Leu Pro Asn Ser Ala Ser Val Ser Ser Ser Leu Asn His Val Pro
      50                  55                  60                
 Asp Leu Glu Ala Gly Pro Ser Ser Tyr Lys Trp Thr His Gln Gln Pro
  65                  70                  75                  80
 Ser Asp Ser Asp Leu Tyr Gln Met Thr Ala Pro Leu Pro Asn Ser Ala
                  85                  90                  95    
 Ser Val Ser Ser Ser Leu Asn His Val Pro Asp Leu Glu Ala Gly Pro
             100                 105                 110        
 Ser Ser Tyr Lys Trp Thr Arg Gln Gln Pro Ser Asp Ser Asp Leu Tyr
         115                 120                 125            
 Gln Met Asn Lys Arg Lys Arg Gln Lys Gln Thr Ser Asp Ser Asp Ser
     130                 135                 140                
 Ser Thr Asp Asn Asn Arg Gly Asn Glu Cys Ser Gln Lys Phe Arg Lys
 145                 150                 155                 160
 Ser Lys Lys Lys Lys Arg Tyr
                 165        



      <210> 308
      <211> 375
      <212> PRT
      <213> Homo sapiens


      <400> 308
 Met Ser Ala Ser Ala Pro Ala Ala Glu Gly Glu Gly Thr Pro Thr Gln
   1               5                  10                  15    
 Pro Ala Ser Glu Lys Glu Pro Glu Met Pro Gly Pro Arg Glu Glu Ser
              20                  25                  30        
 Glu Glu Glu Glu Asp Glu Asp Asp Glu Glu Glu Glu Glu Glu Glu Lys
          35                  40                  45            
 Glu Lys Ser Leu Ile Val Glu Gly Lys Arg Glu Lys Lys Lys Val Glu
      50                  55                  60                
 Arg Leu Thr Met Gln Val Ser Ser Leu Gln Arg Glu Pro Phe Thr Ile
  65                  70                  75                  80
 Ala Gln Gly Lys Gly Gln Lys Leu Cys Glu Ile Glu Arg Ile His Phe
                  85                  90                  95    
 Phe Leu Ser Lys Lys Lys Thr Asp Glu Leu Arg Asn Leu His Lys Leu
             100                 105                 110        
 Leu Tyr Asn Arg Pro Gly Thr Val Ser Ser Leu Lys Lys Asn Val Gly
         115                 120                 125            
 Gln Phe Ser Gly Phe Pro Phe Glu Lys Gly Ser Val Gln Tyr Lys Lys
     130                 135                 140                
 Lys Glu Glu Met Leu Lys Lys Phe Arg Asn Ala Met Leu Lys Ser Ile
 145                 150                 155                 160
 Cys Glu Val Leu Asp Leu Glu Arg Ser Gly Val Asn Ser Glu Leu Val
                 165                 170                 175    
 Lys Arg Ile Leu Asn Phe Leu Met His Pro Lys Pro Ser Gly Lys Pro
             180                 185                 190        
 Leu Pro Lys Ser Lys Lys Thr Cys Ser Lys Gly Ser Lys Lys Glu Arg
         195                 200                 205            
 Asn Ser Ser Gly Met Ala Arg Lys Ala Lys Arg Thr Lys Cys Pro Glu
     210                 215                 220                
 Ile Leu Ser Asp Glu Ser Ser Ser Asp Glu Asp Glu Lys Lys Asn Lys
 225                 230                 235                 240
 Glu Glu Ser Ser Asp Asp Glu Asp Lys Glu Ser Glu Glu Glu Pro Pro
                 245                 250                 255    
 Lys Lys Thr Ala Lys Arg Glu Lys Pro Lys Gln Lys Ala Thr Ser Lys
             260                 265                 270        
 Ser Lys Lys Ser Val Lys Ser Ala Asn Val Lys Lys Ala Asp Ser Ser
         275                 280                 285            
 Thr Thr Lys Lys Asn Gln Asn Ser Ser Lys Lys Glu Ser Glu Ser Glu
     290                 295                 300                
 Asp Ser Ser Asp Asp Glu Pro Leu Ile Lys Lys Leu Lys Lys Pro Pro
 305                 310                 315                 320
 Thr Asp Glu Glu Leu Lys Glu Thr Ile Lys Lys Leu Leu Ala Ser Ala
                 325                 330                 335    
 Asn Leu Glu Glu Val Thr Met Lys Gln Ile Cys Lys Lys Val Tyr Glu
             340                 345                 350        
 Asn Tyr Pro Thr Tyr Asp Leu Thr Glu Arg Lys Asp Phe Ile Lys Thr
         355                 360                 365            
 Thr Val Lys Glu Leu Ile Ser
     370                 375



      <210> 309
      <211> 289
      <212> PRT
      <213> Homo sapiens


      <400> 309
 Met Ala Ala Leu Ala Tyr Asn Leu Gly Lys Arg Glu Ile Asn His Tyr
   1               5                  10                  15    
 Phe Ser Val Arg Ser Ala Lys Val Leu Ala Leu Val Ala Val Leu Leu
              20                  25                  30        
 Leu Ala Ala Cys His Leu Ala Ser Arg Arg Tyr Arg Gly Asn Asp Ser
          35                  40                  45            
 Cys Glu Tyr Leu Leu Ser Ser Gly Arg Phe Leu Gly Glu Lys Val Trp
      50                  55                  60                
 Gln Pro His Ser Cys Met Met His Lys Tyr Lys Ile Ser Glu Ala Lys
  65                  70                  75                  80
 Asn Cys Leu Val Asp Lys His Ile Ala Phe Ile Gly Asp Ser Arg Ile
                  85                  90                  95    
 Arg Gln Leu Phe Tyr Ser Phe Val Lys Ile Ile Asn Pro Gln Phe Lys
             100                 105                 110        
 Glu Glu Gly Asn Lys His Glu Asn Ile Pro Phe Glu Asp Lys Thr Ala
         115                 120                 125            
 Ser Val Lys Val Asp Phe Leu Trp His Pro Glu Val Asn Gly Ser Met
     130                 135                 140                
 Lys Gln Cys Ile Lys Val Trp Thr Glu Asp Ser Ile Ala Lys Pro His
 145                 150                 155                 160
 Val Ile Val Ala Gly Ala Ala Thr Trp Ser Ile Lys Ile His Asn Gly
                 165                 170                 175    
 Ser Ser Glu Ala Leu Ser Gln Tyr Lys Met Asn Ile Thr Ser Ile Ala
             180                 185                 190        
 Pro Leu Leu Glu Lys Leu Ala Lys Thr Ser Asp Val Tyr Trp Val Leu
         195                 200                 205            
 Gln Asp Pro Val Tyr Glu Asp Leu Leu Ser Glu Asn Arg Lys Met Ile
     210                 215                 220                
 Thr Asn Glu Lys Ile Asp Ala Tyr Asn Glu Ala Ala Val Ser Ile Leu
 225                 230                 235                 240
 Asn Ser Ser Thr Arg Asn Ser Lys Ser Asn Val Lys Met Phe Ser Val
                 245                 250                 255    
 Ser Lys Leu Ile Ala Gln Glu Thr Ile Met Glu Ser Leu Asp Gly Leu
             260                 265                 270        
 His Leu Pro Glu Ser Ser Arg Glu Thr Val Arg Asn Phe Tyr Ile Cys
         275                 280                 285            
 Gln
    



      <210> 310
      <211> 274
      <212> PRT
      <213> Homo sapiens


      <400> 310
 Met Ala Ala Leu Ala Tyr Asn Leu Gly Lys Arg Glu Ile Asn His Tyr
   1               5                  10                  15    
 Phe Ser Val Arg Ser Ala Lys Val Leu Ala Leu Val Ala Val Leu Leu
              20                  25                  30        
 Leu Ala Ala Cys His Leu Ala Ser Arg Arg Tyr Arg Gly Asn Asp Ser
          35                  40                  45            
 Cys Glu Tyr Leu Leu Ser Ser Gly Arg Phe Leu Gly Glu Lys Val Trp
      50                  55                  60                
 Gln Pro His Ser Cys Met Met His Lys Tyr Lys Ile Ser Glu Ala Lys
  65                  70                  75                  80
 Asn Cys Leu Val Asp Lys His Ile Ala Phe Ile Gly Asp Ser Arg Ile
                  85                  90                  95    
 Arg Gln Leu Phe Tyr Ser Phe Val Lys Ile Ile Asn Pro Gln Phe Lys
             100                 105                 110        
 Glu Glu Gly Asn Lys Asp Phe Leu Trp His Pro Glu Val Asn Gly Ser
         115                 120                 125            
 Met Lys Gln Cys Ile Lys Val Trp Thr Glu Asp Ser Ile Ala Lys Pro
     130                 135                 140                
 His Val Ile Val Ala Gly Ala Ala Thr Trp Ser Ile Lys Ile His Asn
 145                 150                 155                 160
 Gly Ser Ser Glu Ala Leu Ser Gln Tyr Lys Met Asn Ile Thr Ser Ile
                 165                 170                 175    
 Ala Pro Leu Leu Glu Lys Leu Ala Lys Thr Ser Asp Val Tyr Trp Val
             180                 185                 190        
 Leu Gln Asp Pro Val Tyr Glu Asp Leu Leu Ser Glu Asn Arg Lys Met
         195                 200                 205            
 Ile Thr Asn Glu Lys Ile Asp Ala Tyr Asn Glu Ala Ala Val Ser Ile
     210                 215                 220                
 Leu Asn Ser Ser Thr Arg Asn Ser Lys Ser Asn Val Lys Met Phe Ser
 225                 230                 235                 240
 Val Ser Lys Leu Ile Ala Gln Glu Thr Ile Met Glu Ser Leu Asp Gly
                 245                 250                 255    
 Leu His Leu Pro Glu Ser Ser Arg Glu Thr Val Arg Asn Phe Tyr Ile
             260                 265                 270        
 Cys Gln
        



      <210> 311
      <211> 150
      <212> PRT
      <213> Homo sapiens


      <400> 311
 Met Ala Ala Arg Gly Val Ile Ala Pro Val Gly Glu Ser Leu Arg Tyr
   1               5                  10                  15    
 Ala Glu Tyr Leu Gln Pro Ser Ala Lys Arg Pro Asp Ala Asp Val Asp
              20                  25                  30        
 Gln Gln Gly Leu Val Arg Ser Leu Ile Ala Val Gly Leu Gly Val Ala
          35                  40                  45            
 Ala Leu Ala Phe Ala Gly Arg Tyr Ala Phe Arg Ile Trp Lys Pro Leu
      50                  55                  60                
 Glu Gln Val Ile Thr Glu Thr Ala Lys Lys Ile Ser Thr Pro Ser Phe
  65                  70                  75                  80
 Ser Ser Tyr Tyr Lys Gly Gly Phe Glu Gln Lys Met Ser Arg Arg Glu
                  85                  90                  95    
 Ala Gly Leu Ile Leu Gly Val Ser Pro Ser Ala Gly Lys Ala Lys Ile
             100                 105                 110        
 Arg Thr Ala His Arg Arg Val Met Ile Leu Asn His Pro Asp Lys Gly
         115                 120                 125            
 Gly Ser Pro Tyr Val Ala Ala Lys Ile Asn Glu Ala Lys Asp Leu Leu
     130                 135                 140                
 Glu Thr Thr Thr Lys His
 145                 150



      <210> 312
      <211> 410
      <212> PRT
      <213> Homo sapiens


      <400> 312
 Met Gly Glu Gly Lys Leu Lys Ser Ser Ser Arg Gly Ser His Gly Gly
   1               5                  10                  15    
 Ser Met Arg Glu Ala Gly Ala Thr Arg Ser Pro Gly Val Gly Ile Val
              20                  25                  30        
 Ser Arg Pro Ser Pro Gln Phe Cys Thr Gln Leu Gln Asn Lys Arg Thr
          35                  40                  45            
 Val Ala Ser Thr Trp Lys Arg Met Trp Ile Gln Thr Lys Trp Arg Thr
      50                  55                  60                
 Asp Thr Pro Ser Met Asp Lys Ile Leu Met Glu Glu Val Lys Leu Glu
  65                  70                  75                  80
 Glu Gln Leu Lys Glu Ala Val Glu Glu Asp Lys Gln Ala Leu Ala Asp
                  85                  90                  95    
 Thr Glu Gly Ser Glu Gln Ser Ser Gln Lys Leu Val Glu Glu Gly Asn
             100                 105                 110        
 Met Tyr Ser Ile Gln Gly Phe Cys Lys Asp Ser Leu Glu Val Ala Asp
         115                 120                 125            
 Val Leu Glu Lys Ala Thr Gln Cys Val Pro Glu Glu Glu Ile Lys Asp
     130                 135                 140                
 Asn Asn Pro His Leu Lys Asn Leu Ser Leu Trp Asp His Leu Val Ala
 145                 150                 155                 160
 Gly Lys Glu Gly Gln Asp Ser Gln Ser Phe Tyr Ile Met Ser Met Glu
                 165                 170                 175    
 Lys Leu Ser Ser Thr Lys Leu Val Pro Ala Pro Pro Lys Ile Gly Asp
             180                 185                 190        
 Arg Cys Thr Gln His Arg Glu Lys Asn Lys Lys Leu Lys Ser Leu Pro
         195                 200                 205            
 Leu Ser Pro Gln Pro Arg Cys Leu Thr Pro Leu Ser Leu Met Gln Gln
     210                 215                 220                
 Glu Ala Pro Gly Glu Arg Phe Ser Pro Ile Leu Tyr Phe Cys His Val
 225                 230                 235                 240
 Leu Ile Thr Val Trp Leu Pro Asp Leu Leu Arg Pro Val Phe Ala Ile
                 245                 250                 255    
 Pro Ala Asp Gly Trp Leu Pro Leu Asn Val Asp Cys Asp Glu Met Pro
             260                 265                 270        
 Ala Glu Ala Tyr Ala Ile Gln Ala Lys Gly Ala Thr Leu Asp His Cys
         275                 280                 285            
 Gly Ser Ile Asp Glu Ser Glu Glu Trp Tyr Gly Met Asp Thr Tyr Glu
     290                 295                 300                
 Cys Thr Arg Ala Gly Val Ser Ile His Arg Ala Thr Glu Pro Glu Val
 305                 310                 315                 320
 Ser Ser Arg Pro Arg Thr Val Ser Ser Gly Pro Leu Gln Ala Arg Leu
                 325                 330                 335    
 Ser Ile Arg Ala Ala Ser Ser Gly Pro Asn Pro Cys Leu Thr Thr Thr
             340                 345                 350        
 Thr Phe Gly Pro Ala Pro Gly Ser Leu Cys Arg Pro Gln Ala Pro Arg
         355                 360                 365            
 Lys Ile Leu Ile Gly Glu Val Leu Leu Asp Ala Leu Pro Arg His Glu
     370                 375                 380                
 Val Thr Leu Pro Ser Ser Gly Val Pro Arg Tyr Phe Leu Cys Val Cys
 385                 390                 395                 400
 Leu Val Asp Ser Gln Tyr Leu Thr Arg Leu
                 405                 410



      <210> 313
      <211> 711
      <212> PRT
      <213> Homo sapiens


      <400> 313
 Met Leu Asp Gly Pro Leu Phe Ser Glu Gly Pro Asp Ser Pro Arg Glu
   1               5                  10                  15    
 Leu Gln Asp Glu Glu Ser Gly Ser Cys Leu Trp Val Gln Lys Ser Lys
              20                  25                  30        
 Leu Leu Val Ile Glu Val Lys Thr Ile Ser Cys His Tyr Ser Arg Arg
          35                  40                  45            
 Ala Pro Ser Arg Gln Pro Met Asp Phe Gln Ala Ser His Trp Ala Arg
      50                  55                  60                
 Gly Phe Gln Asn Arg Thr Cys Gly Pro Arg Pro Gly Ser Pro Gln Pro
  65                  70                  75                  80
 Pro Pro Arg Arg Pro Trp Ala Ser Arg Val Leu Gln Glu Ala Thr Asn
                  85                  90                  95    
 Trp Arg Ala Gly Pro Leu Ala Glu Val Arg Ala Arg Glu Gln Glu Lys
             100                 105                 110        
 Arg Lys Ala Ala Ser Gln Glu Arg Glu Ala Lys Glu Thr Glu Arg Lys
         115                 120                 125            
 Arg Arg Lys Ala Gly Gly Ala Arg Arg Ser Pro Pro Gly Arg Pro Arg
     130                 135                 140                
 Pro Glu Pro Arg Asn Ala Pro Arg Val Ala Gln Leu Ala Gly Leu Pro
 145                 150                 155                 160
 Ala Pro Leu Arg Pro Glu Arg Leu Ala Pro Val Gly Arg Ala Pro Arg
                 165                 170                 175    
 Pro Ser Ala Gln Pro Gln Ser Asp Pro Gly Ser Ala Trp Ala Gly Pro
             180                 185                 190        
 Trp Gly Gly Arg Arg Pro Gly Pro Pro Ser Tyr Glu Ala His Leu Leu
         195                 200                 205            
 Leu Arg Gly Ser Ala Gly Thr Ala Pro Arg Arg Arg Trp Asp Arg Pro
     210                 215                 220                
 Pro Pro Tyr Val Ala Pro Pro Ser Tyr Glu Gly Pro His Arg Thr Leu
 225                 230                 235                 240
 Gly Thr Lys Arg Gly Pro Gly Asn Ser Gln Val Pro Thr Ser Ser Ala
                 245                 250                 255    
 Pro Ala Ala Thr Pro Ala Arg Thr Asp Gly Gly Arg Thr Lys Lys Arg
             260                 265                 270        
 Leu Asp Pro Arg Ile Tyr Arg Asp Val Leu Gly Ala Trp Gly Leu Arg
         275                 280                 285            
 Gln Gly Gln Gly Leu Leu Gly Gly Ser Pro Gly Cys Gly Ala Ala Arg
     290                 295                 300                
 Ala Arg Pro Glu Pro Gly Lys Gly Val Val Glu Lys Ser Leu Gly Leu
 305                 310                 315                 320
 Ala Ala Ala Asp Leu Asn Ser Gly Ser Asp Ser His Pro Gln Ala Lys
                 325                 330                 335    
 Ala Thr Gly Ser Ala Gly Thr Glu Ile Ala Pro Ala Gly Ser Ala Thr
             340                 345                 350        
 Ala Ala Pro Cys Ala Pro His Pro Ala Pro Arg Ser Arg His His Leu
         355                 360                 365            
 Lys Gly Ser Arg Glu Gly Lys Glu Gly Glu Gln Ile Trp Phe Pro Lys
     370                 375                 380                
 Cys Trp Ile Pro Ser Pro Lys Lys Gln Pro Pro Arg His Ser Gln Thr
 385                 390                 395                 400
 Leu Pro Arg Pro Trp Ala Pro Gly Gly Thr Gly Trp Arg Glu Ser Leu
                 405                 410                 415    
 Gly Leu Gly Glu Gly Ala Gly Pro Glu Thr Leu Glu Gly Trp Lys Ala
             420                 425                 430        
 Thr Arg Arg Ala His Thr Leu Pro Arg Ser Ser Gln Gly Leu Ser Arg
         435                 440                 445            
 Gly Glu Gly Val Phe Val Ile Asp Ala Thr Cys Val Val Ile Arg Ser
     450                 455                 460                
 Gln Tyr Val Pro Thr Pro Arg Thr Gln Gln Val Gln Leu Leu Pro Ser
 465                 470                 475                 480
 Gly Val Thr Arg Val Val Gly Asp Ser Pro Ser Gln Ser Lys Pro Gly
                 485                 490                 495    
 Lys Glu Glu Gly Glu Gly Ala Thr Val Phe Pro Ser Pro Cys Gln Lys
             500                 505                 510        
 Arg Leu Ser Ser Ser Arg Leu Leu His Gln Pro Gly Gly Gly Arg Gly
         515                 520                 525            
 Gly Glu Ala Glu Gly Gly Arg Pro Gly Asp Ser Thr Leu Glu Glu Arg
     530                 535                 540                
 Thr Phe Arg Ile Leu Gly Leu Pro Ala Pro Glu Val Asn Leu Arg Asp
 545                 550                 555                 560
 Ala Pro Thr Gln Pro Gly Ser Pro Glu His Gln Ala Leu Gly Pro Ala
                 565                 570                 575    
 Ala Ser Gly Ala Gln Gly Arg Ala Glu Gly Ser Glu Val Ala Val Val
             580                 585                 590        
 Gln Arg Arg Ala Gly Arg Gly Trp Ala Arg Thr Pro Gly Pro Tyr Ala
         595                 600                 605            
 Gly Ala Leu Arg Glu Ala Val Ser Arg Ile Arg Arg His Thr Ala Pro
     610                 615                 620                
 Asp Ser Asp Thr Asp Glu Ala Glu Glu Leu Ser Val His Ser Gly Ser
 625                 630                 635                 640
 Ser Asp Gly Ser Asp Thr Glu Ala Pro Gly Ala Ser Trp Arg Asn Glu
                 645                 650                 655    
 Arg Thr Leu Pro Glu Val Gly Asn Ser Ser Pro Glu Glu Asp Gly Lys
             660                 665                 670        
 Thr Ala Glu Leu Ser Asp Ser Val Gly Glu Ile Leu Asp Val Ile Ser
         675                 680                 685            
 Gln Thr Glu Glu Val Leu Phe Gly Val Arg Asp Ile Arg Gly Thr Gln
     690                 695                 700                
 Gln Gly Asn Arg Lys Arg Gln
 705                 710    



      <210> 314
      <211> 201
      <212> PRT
      <213> Homo sapiens


      <400> 314
 Met Leu Gln Gln Asp Ser Asn Asp Asp Thr Glu Asp Val Ser Leu Phe
   1               5                  10                  15    
 Asp Ala Glu Glu Glu Thr Thr Asn Arg Pro Arg Lys Ala Lys Ile Arg
              20                  25                  30        
 His Pro Val Ala Ser Phe Phe His Leu Phe Phe Arg Val Ser Ala Ile
          35                  40                  45            
 Ile Val Cys Leu Leu Cys Glu Leu Leu Ser Ser Ser Phe Ile Thr Cys
      50                  55                  60                
 Met Val Thr Ile Ile Leu Leu Leu Ser Cys Asp Phe Trp Ala Val Lys
  65                  70                  75                  80
 Asn Val Thr Gly Arg Leu Met Val Gly Leu Arg Trp Trp Asn His Ile
                  85                  90                  95    
 Asp Glu Asp Gly Lys Ser His Trp Val Phe Glu Ser Arg Lys Glu Ser
             100                 105                 110        
 Ser Gln Glu Asn Lys Thr Val Ser Glu Ala Glu Ser Arg Ile Phe Trp
         115                 120                 125            
 Leu Gly Leu Ile Ala Cys Ser Val Leu Trp Val Ile Phe Ala Phe Ser
     130                 135                 140                
 Ala Leu Phe Ser Phe Thr Val Lys Trp Leu Ala Val Val Ile Met Gly
 145                 150                 155                 160
 Val Val Leu Gln Gly Ala Asn Leu Tyr Gly Tyr Ile Arg Cys Lys Val
                 165                 170                 175    
 Arg Ser Arg Lys His Leu Thr Ser Met Ala Thr Ser Tyr Phe Gly Lys
             180                 185                 190        
 Gln Phe Leu Arg Gln Asn Thr Trp Arg
         195                 200    



      <210> 315
      <211> 191
      <212> PRT
      <213> Homo sapiens


      <400> 315
 Met Leu Ser Ser Ile Lys Cys Val Leu Val Gly Asp Ser Ala Val Gly
   1               5                  10                  15    
 Lys Thr Ser Leu Leu Val Arg Phe Thr Ser Glu Thr Phe Pro Glu Ala
              20                  25                  30        
 Tyr Lys Pro Thr Val Tyr Glu Asn Thr Gly Val Asp Val Phe Met Asp
          35                  40                  45            
 Gly Ile Gln Ile Ser Leu Gly Leu Trp Asp Thr Ala Gly Asn Asp Ala
      50                  55                  60                
 Phe Arg Ser Ile Arg Pro Leu Ser Tyr Gln Gln Ala Asp Val Val Leu
  65                  70                  75                  80
 Met Cys Tyr Ser Val Ala Asn His Asn Ser Phe Leu Asn Leu Lys Asn
                  85                  90                  95    
 Lys Trp Ile Gly Glu Ile Arg Ser Asn Leu Pro Cys Thr Pro Val Leu
             100                 105                 110        
 Val Val Ala Thr Gln Thr Asp Gln Arg Glu Met Gly Pro His Arg Ala
         115                 120                 125            
 Ser Cys Val Asn Ala Met Glu Gly Lys Lys Leu Ala Gln Asp Val Arg
     130                 135                 140                
 Ala Lys Gly Tyr Leu Glu Cys Ser Ala Leu Ser Asn Arg Gly Val Gln
 145                 150                 155                 160
 Gln Val Phe Glu Cys Ala Val Arg Thr Ala Val Asn Gln Ala Arg Arg
                 165                 170                 175    
 Arg Asn Arg Arg Arg Leu Phe Ser Ile Asn Glu Cys Lys Ile Phe
             180                 185                 190    



      <210> 316
      <211> 413
      <212> PRT
      <213> Homo sapiens


      <400> 316
 Met Ser Phe Arg Asp Leu Arg Asn Phe Thr Glu Met Met Arg Ala Leu
   1               5                  10                  15    
 Gly Tyr Pro Arg His Ile Ser Met Glu Asn Phe Arg Thr Pro Asn Phe
              20                  25                  30        
 Gly Leu Val Ser Glu Val Leu Leu Trp Leu Val Lys Arg Tyr Glu Pro
          35                  40                  45            
 Gln Thr Asp Ile Pro Pro Asp Val Asp Thr Glu Gln Asp Arg Val Phe
      50                  55                  60                
 Phe Ile Lys Ala Ile Ala Gln Phe Met Ala Thr Lys Ala His Ile Lys
  65                  70                  75                  80
 Leu Asn Thr Lys Lys Leu Tyr Gln Ala Asp Gly Tyr Ala Val Lys Glu
                  85                  90                  95    
 Leu Leu Lys Ile Thr Ser Val Leu Tyr Asn Ala Met Lys Thr Lys Gly
             100                 105                 110        
 Met Glu Gly Ser Glu Ile Val Glu Glu Asp Val Asn Lys Phe Lys Phe
         115                 120                 125            
 Asp Leu Gly Ser Lys Ile Ala Asp Leu Lys Ala Ala Arg Gln Leu Ala
     130                 135                 140                
 Ser Glu Ile Thr Ser Lys Gly Ala Ser Leu Tyr Asp Leu Leu Gly Met
 145                 150                 155                 160
 Glu Val Glu Leu Arg Glu Met Arg Thr Glu Ala Ile Ala Arg Pro Leu
                 165                 170                 175    
 Glu Ile Asn Glu Thr Glu Lys Val Met Arg Ile Ala Ile Lys Glu Ile
             180                 185                 190        
 Leu Thr Gln Val Gln Lys Thr Lys Asp Leu Leu Asn Asn Val Ala Ser
         195                 200                 205            
 Asp Glu Ala Asn Leu Glu Ala Lys Ile Glu Lys Arg Lys Leu Glu Leu
     210                 215                 220                
 Glu Arg Asn Arg Lys Arg Leu Glu Thr Leu Gln Ser Val Arg Pro Cys
 225                 230                 235                 240
 Phe Met Asp Glu Tyr Glu Lys Thr Glu Glu Glu Leu Gln Lys Gln Tyr
                 245                 250                 255    
 Asp Thr Tyr Leu Glu Lys Phe Gln Asn Leu Thr Tyr Leu Glu Gln Gln
             260                 265                 270        
 Leu Glu Asp His His Arg Met Glu Gln Glu Arg Phe Glu Glu Ala Lys
         275                 280                 285            
 Asn Thr Leu Cys Leu Ile Gln Asn Lys Leu Lys Glu Glu Glu Lys Arg
     290                 295                 300                
 Leu Leu Lys Ser Gly Ser Asn Asp Asp Ser Asp Ile Asp Ile Gln Glu
 305                 310                 315                 320
 Asp Asp Glu Ser Asp Ser Glu Leu Glu Glu Arg Arg Leu Pro Lys Pro
                 325                 330                 335    
 Gln Thr Ala Met Glu Met Leu Met Gln Gly Arg Pro Gly Lys Arg Ile
             340                 345                 350        
 Val Gly Thr Met Gln Gly Gly Asp Ser Asp Asp Asn Glu Asp Ser Glu
         355                 360                 365            
 Glu Ser Glu Ile Asp Met Glu Asp Asp Asp Asp Glu Asp Asp Asp Leu
     370                 375                 380                
 Glu Asp Glu Ser Ile Ser Leu Ser Pro Thr Lys Pro Asn Arg Arg Val
 385                 390                 395                 400
 Arg Lys Ser Glu Pro Leu Asp Glu Ser Asp Asn Asp Phe
                 405                 410            



      <210> 317
      <211> 424
      <212> PRT
      <213> Homo sapiens


      <400> 317
 Met Glu Ala Ala Gln Ser Ser Ser Thr Ala Ser Ser Ala Cys Ile His
   1               5                  10                  15    
 Cys Gly Gly Cys Tyr Gly Arg Ser Leu Lys Lys Tyr Ser Phe Glu Ser
              20                  25                  30        
 Ile Arg Glu Glu Ser Ser Tyr Ser Asp Ile Pro Asp Val Lys Asn Asp
          35                  40                  45            
 Phe Ala Phe Met Leu His Leu Ile Asp Gln Tyr Asp Pro Leu Tyr Ser
      50                  55                  60                
 Lys Arg Phe Ala Val Phe Leu Ser Glu Val Ser Glu Asn Lys Leu Arg
  65                  70                  75                  80
 Gln Leu Asn Leu Asn Asn Glu Trp Thr Leu Asp Lys Leu Arg Gln Arg
                  85                  90                  95    
 Leu Thr Lys Asn Ala Gln Asp Lys Leu Glu Leu His Leu Phe Met Leu
             100                 105                 110        
 Ser Gly Ile Pro Asp Thr Val Phe Asp Leu Val Glu Leu Glu Val Leu
         115                 120                 125            
 Lys Leu Glu Leu Ile Pro Asp Val Thr Ile Pro Pro Ser Ile Ala Gln
     130                 135                 140                
 Leu Thr Gly Leu Lys Glu Leu Trp Leu Tyr His Thr Ala Ala Lys Ile
 145                 150                 155                 160
 Glu Ala Pro Ala Leu Ala Phe Leu Arg Glu Asn Leu Arg Ala Leu His
                 165                 170                 175    
 Ile Lys Phe Thr Asp Ile Lys Glu Ile Pro Leu Trp Ile Tyr Ser Leu
             180                 185                 190        
 Lys Thr Leu Glu Glu Leu His Leu Thr Gly Asn Leu Ser Ala Glu Asn
         195                 200                 205            
 Asn Arg Tyr Ile Val Ile Asp Gly Leu Arg Glu Leu Lys Arg Leu Lys
     210                 215                 220                
 Val Leu Arg Leu Lys Ser Asn Leu Ser Lys Leu Pro Gln Val Val Thr
 225                 230                 235                 240
 Asp Val Gly Val His Leu Gln Lys Leu Ser Ile Asn Asn Glu Gly Thr
                 245                 250                 255    
 Lys Leu Ile Leu Trp Tyr Asn His Ile Ala Tyr Ile Pro Ile Gln Ile
             260                 265                 270        
 Gly Asn Leu Thr Asn Leu Glu Arg Leu Tyr Leu Asn Arg Asn Lys Ile
         275                 280                 285            
 Glu Lys Ile Pro Thr Gln Leu Phe Tyr Cys Arg Lys Leu Arg Tyr Leu
     290                 295                 300                
 Asp Leu Ser His Asn Asn Leu Thr Phe Leu Pro Ala Asp Ile Gly Leu
 305                 310                 315                 320
 Leu Gln Asn Leu Gln Asn Leu Ala Ile Thr Ala Asn Arg Ile Glu Thr
                 325                 330                 335    
 Leu Pro Pro Glu Leu Phe Gln Cys Arg Lys Leu Arg Ala Leu His Leu
             340                 345                 350        
 Gly Asn Asn Val Leu Gln Ser Leu Pro Ser Arg Val Gly Glu Leu Thr
         355                 360                 365            
 Asn Leu Thr Gln Ile Glu Leu Arg Gly Asn Arg Leu Glu Cys Leu Pro
     370                 375                 380                
 Val Glu Leu Gly Glu Cys Pro Leu Leu Lys Arg Ser Gly Leu Val Val
 385                 390                 395                 400
 Glu Glu Asp Leu Phe Asn Thr Leu Pro Pro Glu Val Lys Glu Arg Leu
                 405                 410                 415    
 Trp Arg Ala Asp Lys Glu Gln Ala
             420                



      <210> 318
      <211> 400
      <212> PRT
      <213> Homo sapiens


      <400> 318
 Met Arg Arg Ala Pro Ala Ala Glu Arg Leu Leu Glu Leu Gly Phe Pro
   1               5                  10                  15    
 Pro Arg Cys Gly Arg Gln Glu Pro Pro Phe Pro Leu Gly Val Thr Arg
              20                  25                  30        
 Gly Trp Gly Arg Trp Pro Ile Gln Lys Arg Arg Glu Gly Ala Arg Pro
          35                  40                  45            
 Val Pro Phe Ser Glu Arg Ser Gln Glu Asp Gly Arg Gly Pro Ala Ala
      50                  55                  60                
 Arg Ser Ser Gly Thr Leu Trp Arg Ile Arg Thr Arg Leu Ser Leu Cys
  65                  70                  75                  80
 Arg Asp Pro Glu Pro Pro Pro Pro Leu Cys Leu Leu Arg Val Ser Leu
                  85                  90                  95    
 Leu Cys Ala Leu Arg Ala Gly Gly Arg Gly Ser Arg Trp Gly Glu Asp
             100                 105                 110        
 Gly Ala Arg Leu Leu Leu Leu Pro Pro Ala Arg Ala Ala Gly Asn Gly
         115                 120                 125            
 Glu Ala Glu Pro Ser Gly Gly Pro Ser Tyr Ala Gly Arg Met Leu Glu
     130                 135                 140                
 Ser Ser Gly Cys Lys Ala Leu Lys Glu Gly Val Leu Glu Lys Arg Ser
 145                 150                 155                 160
 Asp Gly Leu Leu Gln Leu Trp Lys Lys Lys Cys Cys Ile Leu Thr Glu
                 165                 170                 175    
 Glu Gly Leu Leu Leu Ile Pro Pro Lys Gln Leu Gln His Gln Gln Gln
             180                 185                 190        
 Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Gly Gln Gly Pro
         195                 200                 205            
 Ala Glu Pro Ser Gln Pro Ser Gly Pro Ala Val Ala Ser Leu Glu Pro
     210                 215                 220                
 Pro Val Lys Leu Lys Glu Leu His Phe Ser Asn Met Lys Thr Val Asp
 225                 230                 235                 240
 Cys Val Glu Arg Lys Gly Lys Tyr Met Tyr Phe Thr Val Val Met Ala
                 245                 250                 255    
 Glu Gly Lys Glu Ile Asp Phe Arg Cys Pro Gln Asp Gln Gly Trp Asn
             260                 265                 270        
 Ala Glu Ile Thr Leu Gln Met Val Gln Tyr Lys Asn Arg Gln Ala Ile
         275                 280                 285            
 Leu Ala Val Lys Ser Thr Arg Gln Lys Gln Gln His Leu Val Gln Gln
     290                 295                 300                
 Gln Pro Pro Ser Gln Pro Gln Pro Gln Pro Gln Leu Gln Pro Gln Pro
 305                 310                 315                 320
 Gln Pro Gln Pro Gln Pro Gln Pro Gln Pro Gln Ser Gln Pro Gln Pro
                 325                 330                 335    
 Gln Pro Gln Pro Lys Pro Gln Pro Gln Gln Leu His Pro Tyr Pro His
             340                 345                 350        
 Pro His Pro His Pro His Ser His Pro His Ser His Pro His Pro His
         355                 360                 365            
 Pro His Pro His Pro His Gln Ile Pro His Pro His Pro Gln Pro His
     370                 375                 380                
 Ser Gln Pro His Gly His Arg Leu Leu Arg Ser Thr Ser Asn Ser Ala
 385                 390                 395                 400





      <210> 319
      <211> 1272
      <212> PRT
      <213> Homo sapiens


      <400> 319
 Met Ala Arg Thr Val Val Leu Ile Thr Gly Cys Ser Ser Gly Ile Gly
   1               5                  10                  15    
 Leu His Leu Ala Val Arg Leu Ala Ser Asp Pro Ser Gln Ser Phe Lys
              20                  25                  30        
 Val Tyr Ala Thr Leu Arg Asp Leu Lys Thr Gln Gly Arg Leu Trp Glu
          35                  40                  45            
 Ala Ala Arg Ala Leu Ala Cys Pro Pro Gly Ser Leu Glu Thr Leu Gln
      50                  55                  60                
 Leu Asp Val Arg Asp Ser Lys Ser Val Ala Ala Ala Arg Glu Arg Val
  65                  70                  75                  80
 Thr Glu Gly Arg Val Asp Val Leu Val Cys Asn Ala Gly Leu Gly Leu
                  85                  90                  95    
 Leu Gly Pro Leu Glu Ala Leu Gly Glu Asp Ala Val Ala Ser Val Leu
             100                 105                 110        
 Asp Val Asn Val Val Gly Thr Val Arg Met Leu Gln Ala Phe Leu Pro
         115                 120                 125            
 Asp Met Lys Arg Arg Gly Ser Gly Arg Val Leu Val Thr Gly Ser Val
     130                 135                 140                
 Gly Gly Leu Met Gly Leu Pro Phe Asn Asp Val Tyr Cys Ala Ser Lys
 145                 150                 155                 160
 Phe Ala Leu Glu Gly Leu Cys Glu Ser Leu Ala Val Leu Leu Leu Pro
                 165                 170                 175    
 Phe Gly Val His Ser Leu Ser Leu Ile Glu Cys Gly Pro Val His Thr
             180                 185                 190        
 Ala Phe Met Glu Lys Val Leu Gly Ser Pro Glu Glu Val Leu Asp Arg
         195                 200                 205            
 Thr Asp Ile His Thr Phe His Arg Phe Tyr Gln Tyr Leu Ala His Ser
     210                 215                 220                
 Lys Gln Val Phe Arg Glu Ala Ala Gln Asn Pro Glu Glu Val Ala Glu
 225                 230                 235                 240
 Val Phe Leu Thr Ala Leu Arg Ala Pro Lys Pro Thr Leu Arg Tyr Phe
                 245                 250                 255    
 Thr Thr Glu Arg Phe Leu Pro Leu Leu Arg Met Arg Leu Asp Asp Pro
             260                 265                 270        
 Ser Gly Ser Asn Tyr Val Thr Ala Met His Arg Glu Val Phe Gly Asp
         275                 280                 285            
 Val Pro Ala Lys Ala Glu Ala Gly Ala Glu Ala Gly Gly Gly Ala Gly
     290                 295                 300                
 Pro Gly Ala Glu Asp Glu Ala Gly Arg Ser Ala Arg Pro Arg Lys Gln
 305                 310                 315                 320
 Ala His Gln Arg Ile Trp Val Val Arg Glu Pro Pro Thr Ala Ala Arg
                 325                 330                 335    
 Tyr Thr Gln Gly Leu Ser Phe Ser Ile Cys Glu Met Gly Thr Trp Thr
             340                 345                 350        
 Asp Leu Ser Ser Ser Leu Pro Cys Glu Asn Pro Arg Thr Glu Arg Arg
         355                 360                 365            
 Gly Ser Asp Arg His Gln Gly Phe Thr His Ser Gln Ser Leu Arg Asp
     370                 375                 380                
 Gln Pro His Pro Ile Ser Arg Thr Gln Pro Met Pro Leu Glu Ile Ser
 385                 390                 395                 400
 Arg Glu Ser Arg Ala Glu Ala Lys Ser Arg Arg Leu Thr Phe Leu Arg
                 405                 410                 415    
 Phe Arg Ser Ser Glu Leu Arg Phe Leu Arg Leu Gly Ser Met Ala Val
             420                 425                 430        
 Phe Arg Ser Gly Leu Leu Val Leu Thr Thr Pro Leu Ala Ser Leu Ala
         435                 440                 445            
 Pro Arg Leu Ala Ser Ile Leu Thr Ser Ala Ala Arg Leu Val Asn His
     450                 455                 460                
 Thr Leu Tyr Val His Leu Gln Pro Gly Met Ser Leu Glu Gly Pro Ala
 465                 470                 475                 480
 Gln Pro Gln Tyr Ser Pro Val Gln Ala Thr Phe Glu Val Leu Asp Phe
                 485                 490                 495    
 Ile Thr His Leu Tyr Ala Gly Ala Asp Val His Arg His Leu Asp Val
             500                 505                 510        
 Arg Ile Leu Leu Thr Asn Ile Arg Thr Lys Ser Thr Phe Leu Pro Pro
         515                 520                 525            
 Leu Pro Thr Ser Val Gln Asn Leu Ala His Pro Pro Glu Val Val Leu
     530                 535                 540                
 Thr Asp Phe Gln Thr Leu Asp Gly Ser Gln Tyr Asn Pro Val Lys Gln
 545                 550                 555                 560
 Gln Leu Val Arg Tyr Ala Thr Ser Cys Tyr Ser Cys Cys Pro Arg Leu
                 565                 570                 575    
 Ala Ser Val Leu Leu Tyr Ser Asp Tyr Gly Ile Gly Glu Val Pro Val
             580                 585                 590        
 Glu Pro Leu Asp Val Pro Leu Pro Ser Thr Ile Arg Pro Ala Ser Pro
         595                 600                 605            
 Val Ala Gly Ser Pro Lys Gln Pro Val Arg Gly Tyr Tyr Arg Gly Ala
     610                 615                 620                
 Val Gly Gly Thr Phe Asp Arg Leu His Asn Ala His Lys Val Leu Leu
 625                 630                 635                 640
 Ser Val Ala Cys Ile Leu Ala Gln Glu Gln Leu Val Val Gly Val Ala
                 645                 650                 655    
 Asp Lys Asp Leu Leu Lys Ser Lys Leu Leu Pro Glu Leu Leu Gln Pro
             660                 665                 670        
 Tyr Thr Glu Arg Val Glu His Leu Ser Glu Phe Leu Val Asp Ile Lys
         675                 680                 685            
 Pro Ser Leu Thr Phe Asp Val Ile Pro Leu Leu Asp Pro Tyr Gly Pro
     690                 695                 700                
 Ala Gly Ser Asp Pro Ser Leu Glu Phe Leu Val Val Ser Glu Glu Thr
 705                 710                 715                 720
 Tyr Arg Gly Gly Met Ala Ile Asn Arg Phe Arg Leu Glu Asn Asp Leu
                 725                 730                 735    
 Glu Glu Leu Ala Leu Tyr Gln Ile Gln Leu Leu Lys Asp Leu Arg His
             740                 745                 750        
 Thr Glu Asn Glu Glu Asp Lys Val Ser Ser Ser Ser Phe Arg Gln Arg
         755                 760                 765            
 Met Leu Gly Asn Leu Leu Arg Pro Pro Tyr Glu Arg Pro Glu Leu Pro
     770                 775                 780                
 Thr Cys Leu Tyr Val Ile Gly Leu Thr Gly Ile Ser Gly Ser Gly Lys
 785                 790                 795                 800
 Ser Ser Ile Ala Gln Arg Leu Lys Gly Leu Gly Ala Phe Val Ile Asp
                 805                 810                 815    
 Ser Asp His Leu Gly His Arg Ala Tyr Ala Pro Gly Gly Pro Ala Tyr
             820                 825                 830        
 Gln Pro Val Val Glu Ala Phe Gly Thr Asp Ile Leu His Lys Asp Gly
         835                 840                 845            
 Ile Ile Asn Arg Lys Val Leu Gly Ser Arg Val Phe Gly Asn Lys Lys
     850                 855                 860                
 Gln Leu Lys Ile Leu Thr Asp Ile Met Trp Pro Ile Ile Ala Lys Leu
 865                 870                 875                 880
 Ala Arg Glu Glu Met Asp Arg Ala Val Ala Glu Gly Lys Arg Val Cys
                 885                 890                 895    
 Val Ile Asp Ala Ala Val Leu Leu Glu Ala Gly Trp Gln Asn Leu Val
             900                 905                 910        
 His Glu Val Trp Thr Ala Val Ile Pro Glu Thr Glu Ala Val Arg Arg
         915                 920                 925            
 Ile Val Glu Arg Asp Gly Leu Ser Glu Ala Ala Ala Gln Ser Arg Leu
     930                 935                 940                
 Gln Ser Gln Met Ser Gly Gln Gln Leu Val Glu Gln Ser His Val Val
 945                 950                 955                 960
 Leu Ser Thr Leu Trp Glu Pro His Ile Thr Gln Arg Gln Ser Leu Gln
                 965                 970                 975    
 Pro Gly Gly Val Gly Arg Cys Gly Trp Gly Leu Leu Cys Pro Val Pro
             980                 985                 990        
 Asp Thr Pro Ala Ser Ser Ala Gly Pro Val Glu Tyr Ala Tyr Ser Asp
         995                1000                1005            
 Asn Ser Leu Asp Pro Gly Leu Phe Val Glu Ser Thr Arg Lys Gly Ser
    1010                1015                1020                
 Val Val Ser Arg Ala Asn Ser Ile Gly Ser Thr Ser Ala Ser Ser Val
1025                1030                1035                1040
 Pro Asn Thr Asp Asp Glu Asp Ser Asp Tyr His Gln Glu Ala Tyr Lys
                1045                1050                1055    
 Glu Ser Tyr Lys Asp Arg Arg Arg Arg Ala His Thr Gln Ala Glu Gln
            1060                1065                1070        
 Lys Arg Arg Asp Ala Ile Lys Arg Gly Tyr Asp Asp Leu Gln Thr Ile
        1075                1080                1085            
 Val Pro Thr Cys Gln Gln Gln Asp Phe Ser Ile Gly Ser Gln Lys Leu
    1090                1095                1100                
 Ser Lys Ala Ile Val Leu Gln Lys Ser Met Ala Arg Glu Ser Thr Gly
1105                1110                1115                1120
 Gly Asp Gly Ala Lys Arg Gly Cys Glu Glu Ala Ser Ala Ser Tyr Pro
                1125                1130                1135    
 Pro Met Ala Arg Pro Trp Cys Gly Asp Cys His Gly Ile Val Gly Val
            1140                1145                1150        
 Trp Ala Ile Asp Tyr Ile Gln Phe Leu His Lys Glu Lys Lys Lys Gln
        1155                1160                1165            
 Glu Glu Glu Val Ser Thr Leu Arg Lys Asp Val Thr Ala Leu Lys Ile
    1170                1175                1180                
 Met Lys Val Asn Tyr Glu Gln Ile Val Lys Ala His Arg Asp Asn Pro
1185                1190                1195                1200
 His Glu Gly Glu Asp Gln Val Ser Asp Gln Val Lys Phe Asn Val Phe
                1205                1210                1215    
 Gln Gly Ile Met Asp Ser Leu Phe Gln Ser Phe Asn Ala Ser Ile Ser
            1220                1225                1230        
 Val Ala Ser Phe Gln Glu Leu Ser Ala Cys Val Phe Ser Trp Ile Glu
        1235                1240                1245            
 Glu His Cys Lys Pro Gln Thr Leu Arg Glu Ile Val Ile Gly Val Leu
    1250                1255                1260                
 His Gln Leu Lys Asn Gln Leu Tyr
1265                1270        



      <210> 320
      <211> 1025
      <212> PRT
      <213> Homo sapiens


      <400> 320
 Met Ala Arg Thr Val Val Leu Ile Thr Gly Cys Ser Ser Gly Ile Gly
   1               5                  10                  15    
 Leu His Leu Ala Val Arg Leu Ala Ser Asp Pro Ser Gln Ser Phe Lys
              20                  25                  30        
 Val Tyr Ala Thr Leu Arg Asp Leu Lys Thr Gln Gly Arg Leu Trp Glu
          35                  40                  45            
 Ala Ala Arg Ala Leu Ala Cys Pro Pro Gly Ser Leu Glu Thr Leu Gln
      50                  55                  60                
 Leu Asp Val Arg Asp Ser Lys Ser Val Ala Ala Ala Arg Glu Arg Val
  65                  70                  75                  80
 Thr Glu Gly Arg Val Asp Val Leu Val Cys Asn Ala Gly Leu Gly Leu
                  85                  90                  95    
 Leu Gly Pro Leu Glu Ala Leu Gly Glu Asp Ala Val Ala Ser Val Leu
             100                 105                 110        
 Asp Val Asn Val Val Gly Thr Val Arg Met Leu Gln Ala Phe Leu Pro
         115                 120                 125            
 Asp Met Lys Arg Arg Gly Ser Gly Arg Val Leu Val Thr Gly Ser Val
     130                 135                 140                
 Gly Gly Leu Met Gly Leu Pro Phe Asn Asp Val Tyr Cys Ala Ser Lys
 145                 150                 155                 160
 Phe Ala Leu Glu Gly Leu Cys Glu Ser Leu Ala Val Leu Leu Leu Pro
                 165                 170                 175    
 Phe Gly Val His Ser Leu Ser Leu Ile Glu Cys Gly Pro Val His Thr
             180                 185                 190        
 Ala Phe Met Glu Lys Val Leu Gly Ser Pro Glu Glu Val Leu Asp Arg
         195                 200                 205            
 Thr Asp Ile His Thr Phe His Arg Phe Tyr Gln Tyr Leu Ala His Ser
     210                 215                 220                
 Lys Gln Val Phe Arg Glu Ala Ala Gln Asn Pro Glu Glu Val Ala Glu
 225                 230                 235                 240
 Val Phe Leu Thr Ala Leu Arg Ala Pro Lys Pro Thr Leu Arg Tyr Phe
                 245                 250                 255    
 Thr Thr Glu Arg Phe Leu Pro Leu Leu Arg Met Arg Leu Asp Asp Pro
             260                 265                 270        
 Ser Gly Ser Asn Tyr Val Thr Ala Met His Arg Glu Val Phe Gly Asp
         275                 280                 285            
 Val Pro Ala Lys Ala Glu Ala Gly Ala Glu Ala Gly Gly Gly Ala Gly
     290                 295                 300                
 Pro Gly Ala Glu Asp Glu Ala Gly Arg Ser Ala Arg Pro Arg Lys Gln
 305                 310                 315                 320
 Ala His Gln Arg Ile Trp Val Val Arg Glu Pro Pro Thr Ala Ala Arg
                 325                 330                 335    
 Tyr Thr Gln Gly Leu Ser Phe Ser Ile Cys Glu Met Gly Thr Trp Thr
             340                 345                 350        
 Asp Leu Ser Ser Ser Leu Pro Cys Glu Asn Pro Arg Thr Glu Arg Arg
         355                 360                 365            
 Gly Ser Asp Arg His Gln Gly Phe Thr His Ser Gln Ser Leu Arg Asp
     370                 375                 380                
 Gln Pro His Pro Ile Ser Arg Thr Gln Pro Met Pro Leu Glu Ile Ser
 385                 390                 395                 400
 Arg Glu Ser Arg Ala Glu Ala Lys Ser Arg Arg Leu Thr Phe Leu Arg
                 405                 410                 415    
 Phe Arg Ser Ser Glu Leu Arg Phe Leu Arg Leu Gly Ser Met Ala Val
             420                 425                 430        
 Phe Arg Ser Gly Leu Leu Val Leu Thr Thr Pro Leu Ala Ser Leu Ala
         435                 440                 445            
 Pro Arg Leu Ala Ser Ile Leu Thr Ser Ala Ala Arg Leu Val Asn His
     450                 455                 460                
 Thr Leu Tyr Val His Leu Gln Pro Gly Met Ser Leu Glu Gly Pro Ala
 465                 470                 475                 480
 Gln Pro Gln Tyr Ser Pro Val Gln Ala Thr Phe Glu Val Leu Asp Phe
                 485                 490                 495    
 Ile Thr His Leu Tyr Ala Gly Ala Asp Val His Arg His Leu Asp Val
             500                 505                 510        
 Arg Ile Leu Leu Thr Asn Ile Arg Thr Lys Ser Thr Phe Leu Pro Pro
         515                 520                 525            
 Leu Pro Thr Ser Val Gln Asn Leu Ala His Pro Pro Glu Val Val Leu
     530                 535                 540                
 Thr Asp Phe Gln Thr Leu Asp Gly Ser Gln Tyr Asn Pro Val Lys Gln
 545                 550                 555                 560
 Gln Leu Val Arg Tyr Ala Thr Ser Cys Tyr Ser Cys Cys Pro Arg Leu
                 565                 570                 575    
 Ala Ser Val Leu Leu Tyr Ser Asp Tyr Gly Ile Gly Glu Val Pro Val
             580                 585                 590        
 Glu Pro Leu Asp Val Pro Leu Pro Ser Thr Ile Arg Pro Ala Ser Pro
         595                 600                 605            
 Val Ala Gly Ser Pro Lys Gln Pro Val Arg Gly Tyr Tyr Arg Gly Ala
     610                 615                 620                
 Val Gly Gly Thr Phe Asp Arg Leu His Asn Ala His Lys Val Leu Leu
 625                 630                 635                 640
 Ser Val Ala Cys Ile Leu Ala Gln Glu Gln Leu Val Val Gly Val Ala
                 645                 650                 655    
 Asp Lys Asp Leu Leu Lys Ser Lys Leu Leu Pro Glu Leu Leu Gln Pro
             660                 665                 670        
 Tyr Thr Glu Arg Val Glu His Leu Ser Glu Phe Leu Val Asp Ile Lys
         675                 680                 685            
 Pro Ser Leu Thr Phe Asp Val Ile Pro Leu Leu Asp Pro Tyr Gly Pro
     690                 695                 700                
 Ala Gly Ser Asp Pro Ser Leu Glu Phe Leu Val Val Ser Glu Glu Thr
 705                 710                 715                 720
 Tyr Arg Gly Gly Met Ala Ile Asn Arg Phe Arg Leu Glu Asn Asp Leu
                 725                 730                 735    
 Glu Glu Leu Ala Leu Tyr Gln Ile Gln Leu Leu Lys Asp Leu Arg His
             740                 745                 750        
 Thr Glu Asn Glu Glu Asp Lys Val Ser Ser Ser Ser Phe Arg Gln Arg
         755                 760                 765            
 Met Leu Gly Asn Leu Leu Arg Pro Pro Tyr Glu Arg Pro Glu Leu Pro
     770                 775                 780                
 Thr Cys Leu Tyr Val Ile Gly Leu Thr Gly Ile Ser Gly Ser Gly Lys
 785                 790                 795                 800
 Ser Ser Ile Ala Gln Arg Leu Lys Gly Leu Gly Ala Phe Val Ile Asp
                 805                 810                 815    
 Ser Asp His Leu Gly His Arg Ala Tyr Ala Pro Gly Gly Pro Ala Tyr
             820                 825                 830        
 Gln Pro Val Val Glu Ala Phe Gly Thr Asp Ile Leu His Lys Asp Gly
         835                 840                 845            
 Ile Ile Asn Arg Lys Val Leu Gly Ser Arg Val Phe Gly Asn Lys Lys
     850                 855                 860                
 Gln Leu Lys Ile Leu Thr Asp Ile Met Trp Pro Ile Ile Ala Lys Leu
 865                 870                 875                 880
 Ala Arg Glu Glu Met Asp Arg Ala Val Ala Glu Gly Lys Arg Val Cys
                 885                 890                 895    
 Val Ile Asp Ala Ala Val Leu Leu Glu Ala Gly Trp Gln Asn Leu Val
             900                 905                 910        
 His Glu Val Trp Thr Ala Val Ile Pro Glu Thr Glu Ala Val Arg Arg
         915                 920                 925            
 Ile Val Glu Arg Asp Gly Leu Ser Glu Ala Ala Ala Gln Ser Arg Leu
     930                 935                 940                
 Gln Ser Gln Met Ser Gly Gln Gln Leu Val Glu Gln Ser His Val Val
 945                 950                 955                 960
 Leu Ser Thr Leu Trp Glu Pro His Ile Thr Gln Arg Gln Ser Leu Gln
                 965                 970                 975    
 Pro Gly Gly Val Gly Arg Cys Gly Trp Gly Leu Leu Cys Pro Val Pro
             980                 985                 990        
 Asp Thr Pro Ala Ser Ser Ala Gly Pro Val Glu Tyr Ala Tyr Thr Gly
         995                1000                1005            
 Pro Arg Ala Phe Cys Arg Lys His Pro Gln Gly Glu Cys Ser Val Gln
    1010                1015                1020                
 Ser
1025



      <210> 321
      <211> 1021
      <212> PRT
      <213> Homo sapiens


      <400> 321
 Met Ala Arg Thr Val Val Leu Ile Thr Gly Cys Ser Ser Gly Ile Gly
   1               5                  10                  15    
 Leu His Leu Ala Val Arg Leu Ala Ser Asp Pro Ser Gln Ser Phe Lys
              20                  25                  30        
 Val Tyr Ala Thr Leu Arg Asp Leu Lys Thr Gln Gly Arg Leu Trp Glu
          35                  40                  45            
 Ala Ala Arg Ala Leu Ala Cys Pro Pro Gly Ser Leu Glu Thr Leu Gln
      50                  55                  60                
 Leu Asp Val Arg Asp Ser Lys Ser Val Ala Ala Ala Arg Glu Arg Val
  65                  70                  75                  80
 Thr Glu Gly Arg Val Asp Val Leu Val Cys Asn Ala Gly Leu Gly Leu
                  85                  90                  95    
 Leu Gly Pro Leu Glu Ala Leu Gly Glu Asp Ala Val Ala Ser Val Leu
             100                 105                 110        
 Asp Val Asn Val Val Gly Thr Val Arg Met Leu Gln Ala Phe Leu Pro
         115                 120                 125            
 Asp Met Lys Arg Arg Gly Ser Gly Arg Val Leu Val Thr Gly Ser Val
     130                 135                 140                
 Gly Gly Leu Met Gly Leu Pro Phe Asn Asp Val Tyr Cys Ala Ser Lys
 145                 150                 155                 160
 Phe Ala Leu Glu Gly Leu Cys Glu Ser Leu Ala Val Leu Leu Leu Pro
                 165                 170                 175    
 Phe Gly Val His Ser Leu Ser Leu Ile Glu Cys Gly Pro Val His Thr
             180                 185                 190        
 Ala Phe Met Glu Lys Val Leu Gly Ser Pro Glu Glu Val Leu Asp Arg
         195                 200                 205            
 Thr Asp Ile His Thr Phe His Arg Phe Tyr Gln Tyr Leu Ala His Ser
     210                 215                 220                
 Lys Gln Val Phe Arg Glu Ala Ala Gln Asn Pro Glu Glu Val Ala Glu
 225                 230                 235                 240
 Val Phe Leu Thr Ala Leu Arg Ala Pro Lys Pro Thr Leu Arg Tyr Phe
                 245                 250                 255    
 Thr Thr Glu Arg Phe Leu Pro Leu Leu Arg Met Arg Leu Asp Asp Pro
             260                 265                 270        
 Ser Gly Ser Asn Tyr Val Thr Ala Met His Arg Glu Val Phe Gly Asp
         275                 280                 285            
 Val Pro Ala Lys Ala Glu Ala Gly Ala Glu Ala Gly Gly Gly Ala Gly
     290                 295                 300                
 Pro Gly Ala Glu Asp Glu Ala Gly Arg Ser Ala Arg Pro Arg Lys Gln
 305                 310                 315                 320
 Ala His Gln Arg Ile Trp Val Val Arg Glu Pro Pro Thr Ala Ala Arg
                 325                 330                 335    
 Tyr Thr Gln Gly Leu Ser Phe Ser Ile Cys Glu Met Gly Thr Trp Thr
             340                 345                 350        
 Asp Leu Ser Ser Ser Leu Pro Cys Glu Asn Pro Arg Thr Glu Arg Arg
         355                 360                 365            
 Gly Ser Asp Arg His Gln Gly Phe Thr His Ser Gln Ser Leu Arg Asp
     370                 375                 380                
 Gln Pro His Pro Ile Ser Arg Thr Gln Pro Met Pro Leu Glu Ile Ser
 385                 390                 395                 400
 Arg Glu Ser Arg Ala Glu Ala Lys Ser Arg Arg Leu Thr Phe Leu Arg
                 405                 410                 415    
 Phe Arg Ser Ser Glu Leu Arg Phe Leu Arg Leu Gly Ser Met Ala Val
             420                 425                 430        
 Phe Arg Ser Gly Leu Leu Val Leu Thr Thr Pro Leu Ala Ser Leu Ala
         435                 440                 445            
 Pro Arg Leu Ala Ser Ile Leu Thr Ser Ala Ala Arg Leu Val Asn His
     450                 455                 460                
 Thr Leu Tyr Val His Leu Gln Pro Gly Met Ser Leu Glu Gly Pro Ala
 465                 470                 475                 480
 Gln Pro Gln Tyr Ser Pro Val Gln Ala Thr Phe Glu Val Leu Asp Phe
                 485                 490                 495    
 Ile Thr His Leu Tyr Ala Gly Ala Asp Val His Arg His Leu Asp Val
             500                 505                 510        
 Arg Ile Leu Leu Thr Asn Ile Arg Thr Lys Ser Thr Phe Leu Pro Pro
         515                 520                 525            
 Leu Pro Thr Ser Val Gln Asn Leu Ala His Pro Pro Glu Val Val Leu
     530                 535                 540                
 Thr Asp Phe Gln Thr Leu Asp Gly Ser Gln Tyr Asn Pro Val Lys Gln
 545                 550                 555                 560
 Gln Leu Val Arg Tyr Ala Thr Ser Cys Tyr Ser Cys Cys Pro Arg Leu
                 565                 570                 575    
 Ala Ser Val Leu Leu Tyr Ser Asp Tyr Gly Ile Gly Glu Val Pro Val
             580                 585                 590        
 Glu Pro Leu Asp Val Pro Leu Pro Ser Thr Ile Arg Pro Ala Ser Pro
         595                 600                 605            
 Val Ala Gly Ser Pro Lys Gln Pro Val Arg Gly Tyr Tyr Arg Gly Ala
     610                 615                 620                
 Val Gly Gly Thr Phe Asp Arg Leu His Asn Ala His Lys Val Leu Leu
 625                 630                 635                 640
 Ser Val Ala Cys Ile Leu Ala Gln Glu Gln Leu Val Val Gly Val Ala
                 645                 650                 655    
 Asp Lys Asp Leu Leu Lys Ser Lys Leu Leu Pro Glu Leu Leu Gln Pro
             660                 665                 670        
 Tyr Thr Glu Arg Val Glu His Leu Ser Glu Phe Leu Val Asp Ile Lys
         675                 680                 685            
 Pro Ser Leu Thr Phe Asp Val Ile Pro Leu Leu Asp Pro Tyr Gly Pro
     690                 695                 700                
 Ala Gly Ser Asp Pro Ser Leu Glu Phe Leu Val Val Ser Glu Glu Thr
 705                 710                 715                 720
 Tyr Arg Gly Gly Met Ala Ile Asn Arg Phe Arg Leu Glu Asn Asp Leu
                 725                 730                 735    
 Glu Glu Leu Ala Leu Tyr Gln Ile Gln Leu Leu Lys Asp Leu Arg His
             740                 745                 750        
 Thr Glu Asn Glu Glu Asp Lys Val Ser Ser Ser Ser Phe Arg Gln Arg
         755                 760                 765            
 Met Leu Gly Asn Leu Leu Arg Pro Pro Tyr Glu Arg Pro Glu Leu Pro
     770                 775                 780                
 Thr Cys Leu Tyr Val Ile Gly Leu Thr Gly Ile Ser Gly Ser Gly Lys
 785                 790                 795                 800
 Ser Ser Ile Ala Gln Arg Leu Lys Gly Leu Gly Ala Phe Val Ile Asp
                 805                 810                 815    
 Ser Asp His Leu Gly His Arg Ala Tyr Ala Pro Gly Gly Pro Ala Tyr
             820                 825                 830        
 Gln Pro Val Val Glu Ala Phe Gly Thr Asp Ile Leu His Lys Asp Gly
         835                 840                 845            
 Ile Ile Asn Arg Lys Val Leu Gly Ser Arg Val Phe Gly Asn Lys Lys
     850                 855                 860                
 Gln Leu Lys Ile Leu Thr Asp Ile Met Trp Pro Ile Ile Ala Lys Leu
 865                 870                 875                 880
 Ala Arg Glu Glu Met Asp Arg Ala Val Ala Glu Gly Lys Arg Val Cys
                 885                 890                 895    
 Val Ile Asp Ala Ala Val Leu Leu Glu Ala Gly Trp Gln Asn Leu Val
             900                 905                 910        
 His Glu Val Trp Thr Ala Val Ile Pro Glu Thr Glu Ala Val Arg Arg
         915                 920                 925            
 Ile Val Glu Arg Asp Gly Leu Ser Glu Ala Ala Ala Gln Ser Arg Leu
     930                 935                 940                
 Gln Ser Gln Met Ser Gly Gln Gln Leu Val Glu Gln Ser His Val Val
 945                 950                 955                 960
 Leu Ser Thr Leu Trp Glu Pro His Ile Thr Gln Arg Gln Ser Leu Gln
                 965                 970                 975    
 Pro Gly Gly Val Gly Arg Cys Gly Trp Gly Leu Leu Cys Pro Val Pro
             980                 985                 990        
 Asp Thr Pro Ala Ser Ser Ala Gly Pro Val Glu Tyr Ala Tyr Ser Asp
         995                1000                1005            
 Asn Ser Leu Asp Pro Gly Leu Leu Pro Ala Arg Gly Val
    1010                1015                1020    



      <210> 322
      <211> 1046
      <212> PRT
      <213> Homo sapiens


      <400> 322
 Met Ala Arg Thr Val Val Leu Ile Thr Gly Cys Ser Ser Gly Ile Gly
   1               5                  10                  15    
 Leu His Leu Ala Val Arg Leu Ala Ser Asp Pro Ser Gln Ser Phe Lys
              20                  25                  30        
 Val Tyr Ala Thr Leu Arg Asp Leu Lys Thr Gln Gly Arg Leu Trp Glu
          35                  40                  45            
 Ala Ala Arg Ala Leu Ala Cys Pro Pro Gly Ser Leu Glu Thr Leu Gln
      50                  55                  60                
 Leu Asp Val Arg Asp Ser Lys Ser Val Ala Ala Ala Arg Glu Arg Val
  65                  70                  75                  80
 Thr Glu Gly Arg Val Asp Val Leu Val Cys Asn Ala Gly Leu Gly Leu
                  85                  90                  95    
 Leu Gly Pro Leu Glu Ala Leu Gly Glu Asp Ala Val Ala Ser Val Leu
             100                 105                 110        
 Asp Val Asn Val Val Gly Thr Val Arg Met Leu Gln Ala Phe Leu Pro
         115                 120                 125            
 Asp Met Lys Arg Arg Gly Ser Gly Arg Val Leu Val Thr Gly Ser Val
     130                 135                 140                
 Gly Gly Leu Met Gly Leu Pro Phe Asn Asp Val Tyr Cys Ala Ser Lys
 145                 150                 155                 160
 Phe Ala Leu Glu Gly Leu Cys Glu Ser Leu Ala Val Leu Leu Leu Pro
                 165                 170                 175    
 Phe Gly Val His Ser Leu Ser Leu Ile Glu Cys Gly Pro Val His Thr
             180                 185                 190        
 Ala Phe Met Glu Lys Val Leu Gly Ser Pro Glu Glu Val Leu Asp Arg
         195                 200                 205            
 Thr Asp Ile His Thr Phe His Arg Phe Tyr Gln Tyr Leu Ala His Ser
     210                 215                 220                
 Lys Gln Val Phe Arg Glu Ala Ala Gln Asn Pro Glu Glu Val Ala Glu
 225                 230                 235                 240
 Val Phe Leu Thr Ala Leu Arg Ala Pro Lys Pro Thr Leu Arg Tyr Phe
                 245                 250                 255    
 Thr Thr Glu Arg Phe Leu Pro Leu Leu Arg Met Arg Leu Asp Asp Pro
             260                 265                 270        
 Ser Gly Ser Asn Tyr Val Thr Ala Met His Arg Glu Val Phe Gly Asp
         275                 280                 285            
 Val Pro Ala Lys Ala Glu Ala Gly Ala Glu Ala Gly Gly Gly Ala Gly
     290                 295                 300                
 Pro Gly Ala Glu Asp Glu Ala Gly Arg Ser Ala Arg Pro Arg Lys Gln
 305                 310                 315                 320
 Ala His Gln Arg Ile Trp Val Val Arg Glu Pro Pro Thr Ala Ala Arg
                 325                 330                 335    
 Tyr Thr Gln Gly Leu Ser Phe Ser Ile Cys Glu Met Gly Thr Trp Thr
             340                 345                 350        
 Asp Leu Ser Ser Ser Leu Pro Cys Glu Asn Pro Arg Thr Glu Arg Arg
         355                 360                 365            
 Gly Ser Asp Arg His Gln Gly Phe Thr His Ser Gln Ser Leu Arg Asp
     370                 375                 380                
 Gln Pro His Pro Ile Ser Arg Thr Gln Pro Met Pro Leu Glu Ile Ser
 385                 390                 395                 400
 Arg Glu Ser Arg Ala Glu Ala Lys Ser Arg Arg Leu Thr Phe Leu Arg
                 405                 410                 415    
 Phe Arg Ser Ser Glu Leu Arg Phe Leu Arg Leu Gly Ser Met Ala Val
             420                 425                 430        
 Phe Arg Ser Gly Leu Leu Val Leu Thr Thr Pro Leu Ala Ser Leu Ala
         435                 440                 445            
 Pro Arg Leu Ala Ser Ile Leu Thr Ser Ala Ala Arg Leu Val Asn His
     450                 455                 460                
 Thr Leu Tyr Val His Leu Gln Pro Gly Met Ser Leu Glu Gly Pro Ala
 465                 470                 475                 480
 Gln Pro Gln Tyr Ser Pro Val Gln Ala Thr Phe Glu Val Leu Asp Phe
                 485                 490                 495    
 Ile Thr His Leu Tyr Ala Gly Ala Asp Val His Arg His Leu Asp Val
             500                 505                 510        
 Arg Ile Leu Leu Thr Asn Ile Arg Thr Lys Ser Thr Phe Leu Pro Pro
         515                 520                 525            
 Leu Pro Thr Ser Val Gln Asn Leu Ala His Pro Pro Glu Val Val Leu
     530                 535                 540                
 Thr Asp Phe Gln Thr Leu Asp Gly Ser Gln Tyr Asn Pro Val Lys Gln
 545                 550                 555                 560
 Gln Leu Val Arg Tyr Ala Thr Ser Cys Tyr Ser Cys Cys Pro Arg Leu
                 565                 570                 575    
 Ala Ser Val Leu Leu Tyr Ser Asp Tyr Gly Ile Gly Glu Val Pro Val
             580                 585                 590        
 Glu Pro Leu Asp Val Pro Leu Pro Ser Thr Ile Arg Pro Ala Ser Pro
         595                 600                 605            
 Val Ala Gly Ser Pro Lys Gln Pro Val Arg Gly Tyr Tyr Arg Gly Ala
     610                 615                 620                
 Val Gly Gly Thr Phe Asp Arg Leu His Asn Ala His Lys Val Leu Leu
 625                 630                 635                 640
 Ser Val Ala Cys Ile Leu Ala Gln Glu Gln Leu Val Val Gly Val Ala
                 645                 650                 655    
 Asp Lys Asp Leu Leu Lys Ser Lys Leu Leu Pro Glu Leu Leu Gln Pro
             660                 665                 670        
 Tyr Thr Glu Arg Val Glu His Leu Ser Glu Phe Leu Val Asp Ile Lys
         675                 680                 685            
 Pro Ser Leu Thr Phe Asp Val Ile Pro Leu Leu Asp Pro Tyr Gly Pro
     690                 695                 700                
 Ala Gly Ser Asp Pro Ser Leu Glu Phe Leu Val Val Ser Glu Glu Thr
 705                 710                 715                 720
 Tyr Arg Gly Gly Met Ala Ile Asn Arg Phe Arg Leu Glu Asn Asp Leu
                 725                 730                 735    
 Glu Glu Leu Ala Leu Tyr Gln Ile Gln Leu Leu Lys Asp Leu Arg His
             740                 745                 750        
 Thr Glu Asn Glu Glu Asp Lys Val Ser Ser Ser Ser Phe Arg Gln Arg
         755                 760                 765            
 Met Leu Gly Asn Leu Leu Arg Pro Pro Tyr Glu Arg Pro Glu Leu Pro
     770                 775                 780                
 Thr Cys Leu Tyr Val Ile Gly Leu Thr Gly Ile Ser Gly Ser Gly Lys
 785                 790                 795                 800
 Ser Ser Ile Ala Gln Arg Leu Lys Gly Leu Gly Ala Phe Val Ile Asp
                 805                 810                 815    
 Ser Asp His Leu Gly His Arg Ala Tyr Ala Pro Gly Gly Pro Ala Tyr
             820                 825                 830        
 Gln Pro Val Val Glu Ala Phe Gly Thr Asp Ile Leu His Lys Asp Gly
         835                 840                 845            
 Ile Ile Asn Arg Lys Val Leu Gly Ser Arg Val Phe Gly Asn Lys Lys
     850                 855                 860                
 Gln Leu Lys Ile Leu Thr Asp Ile Met Trp Pro Ile Ile Ala Lys Leu
 865                 870                 875                 880
 Ala Arg Glu Glu Met Asp Arg Ala Val Ala Glu Gly Lys Arg Val Cys
                 885                 890                 895    
 Val Ile Asp Ala Ala Val Leu Leu Glu Ala Gly Trp Gln Asn Leu Val
             900                 905                 910        
 His Glu Val Trp Thr Ala Val Ile Pro Glu Thr Glu Ala Val Arg Arg
         915                 920                 925            
 Ile Val Glu Arg Asp Gly Leu Ser Glu Ala Ala Ala Gln Ser Arg Leu
     930                 935                 940                
 Gln Ser Gln Met Ser Gly Gln Gln Leu Val Glu Gln Ser His Val Val
 945                 950                 955                 960
 Leu Ser Thr Leu Trp Glu Pro His Ile Thr Gln Arg Gln Ser Leu Gln
                 965                 970                 975    
 Pro Gly Gly Val Gly Arg Cys Gly Trp Gly Leu Leu Cys Pro Val Pro
             980                 985                 990        
 Asp Thr Pro Ala Ser Ser Ala Gly Pro Val Glu Tyr Ala Tyr Ser Asp
         995                1000                1005            
 Asn Ser Leu Asp Pro Gly Leu Phe Val Glu Ser Thr Arg Lys Gly Ser
    1010                1015                1020                
 Val Val Ser Arg Ala Asn Ser Ile Gly Ser Thr Ser Ala Ser Ser Val
1025                1030                1035                1040
 Pro Asn Thr Glu Arg Arg
                1045    



      <210> 323
      <211> 293
      <212> PRT
      <213> Homo sapiens


      <400> 323
 Met Arg Leu His Arg Leu His Ala Arg Pro Ser Ala Val Ala Cys Gly
   1               5                  10                  15    
 Leu Leu Leu Leu Leu Leu Gln Gly His Tyr Glu Ala Pro Ala Glu Gly
              20                  25                  30        
 Leu Cys Cys Arg Pro Val Ile Thr Val Ile Ala Ser Gly Ser Ser Trp
          35                  40                  45            
 Leu Ser Met Cys Gly Val Leu Gly Gln Gly Gly Ala Leu Ser Pro Pro
      50                  55                  60                
 Lys Gly Pro Gln Thr Ser Met Met Arg Lys Pro Ala Cys Phe Asp Gly
  65                  70                  75                  80
 Ser Lys Leu Gly Lys Phe Gly Lys Glu Ser Lys Asn Met Ala Gly Tyr
                  85                  90                  95    
 Gln Gly Val Ile Ser Trp Asp Thr Lys Gly Glu Lys Gly Gly Lys Met
             100                 105                 110        
 Pro Arg Val Val Pro Asp Gln Arg Ser Lys Phe Glu Asn Glu Glu Phe
         115                 120                 125            
 Phe Arg Lys Leu Ser Arg Glu Cys Glu Ile Lys Tyr Thr Gly Phe Arg
     130                 135                 140                
 Asp Arg Pro His Glu Glu Arg Gln Ala Arg Phe Gln Asn Ala Cys Arg
 145                 150                 155                 160
 Asp Gly Arg Ser Glu Ile Ala Phe Val Ala Thr Gly Thr Asn Leu Ser
                 165                 170                 175    
 Leu Gln Phe Phe Pro Ala Ser Trp Gln Gly Glu Gln Arg Gln Thr Pro
             180                 185                 190        
 Ser Arg Glu Tyr Val Asp Leu Glu Arg Glu Ala Gly Lys Val Tyr Leu
         195                 200                 205            
 Lys Ala Pro Met Ile Leu Asn Gly Val Cys Val Ile Trp Lys Gly Trp
     210                 215                 220                
 Ile Asp Leu Gln Arg Leu Asp Gly Met Gly Cys Leu Glu Phe Asp Glu
 225                 230                 235                 240
 Glu Arg Ala Gln Gln Glu Asp Ala Leu Ala Gln Gln Ala Phe Glu Glu
                 245                 250                 255    
 Ala Arg Arg Arg Thr Arg Glu Phe Glu Asp Arg Asp Arg Ser His Arg
             260                 265                 270        
 Glu Glu Met Glu Val Arg Val Ser Gln Leu Leu Ala Val Thr Gly Lys
         275                 280                 285            
 Lys Thr Thr Arg Pro
     290            



      <210> 324
      <211> 55
      <212> PRT
      <213> Homo sapiens


      <400> 324
 Met Val Pro Ser Ser Ala Ser Gly Gln Val Arg Ser His Tyr Val Asp
   1               5                  10                  15    
 Trp Arg Met Trp Arg Asp Val Lys Arg Arg Lys Met Ala Tyr Glu Tyr
              20                  25                  30        
 Ala Asp Glu Arg Leu Arg Ile Asn Ser Leu Arg Lys Asn Thr Ile Leu
          35                  40                  45            
 Pro Lys Ile Leu Gln Val Ser
      50                  55



      <210> 325
      <211> 570
      <212> PRT
      <213> Homo sapiens


      <400> 325
 Met Ser Cys Glu Val Leu Arg Val Leu Gln Leu Ser Asp Thr Ala Ile
   1               5                  10                  15    
 Val Pro Ile Gly Tyr His Val Pro Arg Lys Ala Val Glu Phe His Glu
              20                  25                  30        
 Asp Leu Phe Pro Asp Thr Ala Gly Cys Val Pro Ala Thr Asp Pro His
          35                  40                  45            
 Ser Trp Trp Ala Gly Asp Asn Gln Gln Val Gln Lys Val Ser Leu Asn
      50                  55                  60                
 Pro Ala Cys Arg Pro His Pro Ser Phe Thr Ser Cys Leu Val Pro Pro
  65                  70                  75                  80
 Ala Glu Pro Leu Pro Asp Thr Ala Gln Pro Ala Val Met Glu Thr Pro
                  85                  90                  95    
 Val Gly Asp Ala Asp Ala Ser Pro Gly Ala Leu Thr Leu Gln His Gln
             100                 105                 110        
 Trp His Arg Asp Gln Pro Gln Phe Glu Val Ala Ala Glu Pro Ala Gly
         115                 120                 125            
 Ser Lys Phe Arg His Ala Gln Gly Thr Val Leu His Arg Asp Ser His
     130                 135                 140                
 Ile Thr Asn Leu Lys Gly Leu Asn Leu Thr Thr Pro Gly Glu Ser Asp
 145                 150                 155                 160
 Gly Phe Cys Ala Asn Lys Leu Arg Val Ala Val Pro Leu Leu Ser Ser
                 165                 170                 175    
 Gly Gly Gln Val Ala Val Leu Glu Leu Arg Lys Pro Gly Arg Leu Pro
             180                 185                 190        
 Asp Thr Ala Leu Pro Thr Leu Gln Asn Gly Ala Ala Val Thr Asp Leu
         195                 200                 205            
 Ala Trp Asp Pro Phe Asp Pro His Arg Leu Ala Val Ala Gly Glu Asp
     210                 215                 220                
 Ala Arg Ile Arg Leu Trp Arg Val Pro Ala Glu Gly Leu Glu Glu Val
 225                 230                 235                 240
 Leu Thr Thr Pro Glu Thr Val Leu Thr Gly His Thr Glu Lys Ile Cys
                 245                 250                 255    
 Ser Leu Arg Phe His Pro Leu Ala Ala Asn Val Leu Ala Ser Ser Ser
             260                 265                 270        
 Tyr Asp Leu Thr Val Arg Ile Trp Asp Leu Gln Ala Gly Ala Asp Arg
         275                 280                 285            
 Leu Lys Leu Gln Gly His Gln Asp Gln Ile Phe Ser Leu Ala Trp Ser
     290                 295                 300                
 Pro Asp Gly Gln Gln Leu Ala Thr Val Cys Lys Asp Gly Arg Val Arg
 305                 310                 315                 320
 Val Tyr Arg Pro Arg Ser Gly Pro Glu Pro Leu Gln Glu Gly Pro Gly
                 325                 330                 335    
 Pro Lys Gly Gly Arg Gly Ala Arg Ile Val Trp Val Cys Asp Gly Arg
             340                 345                 350        
 Cys Leu Leu Val Ser Gly Phe Asp Ser Gln Ser Glu Arg Gln Leu Leu
         355                 360                 365            
 Leu Tyr Glu Ala Glu Ala Leu Ala Gly Gly Pro Leu Ala Val Leu Gly
     370                 375                 380                
 Leu Asp Val Ala Pro Ser Thr Leu Leu Pro Ser Tyr Asp Pro Asp Thr
 385                 390                 395                 400
 Gly Leu Val Leu Leu Thr Gly Lys Gly Asp Thr Arg Val Phe Leu Tyr
                 405                 410                 415    
 Glu Leu Leu Pro Glu Ser Pro Phe Phe Leu Glu Cys Asn Ser Phe Thr
             420                 425                 430        
 Ser Pro Asp Pro His Lys Gly Leu Val Leu Leu Pro Lys Thr Glu Cys
         435                 440                 445            
 Asp Val Arg Glu Val Glu Leu Met Arg Cys Leu Arg Leu Arg Gln Ser
     450                 455                 460                
 Ser Leu Glu Pro Val Ala Phe Arg Leu Pro Arg Val Arg Lys Glu Phe
 465                 470                 475                 480
 Phe Gln Asp Asp Val Phe Pro Asp Thr Ala Val Ile Trp Glu Pro Val
                 485                 490                 495    
 Leu Ser Ala Glu Ala Trp Leu Gln Gly Ala Asn Gly Gln Pro Trp Leu
             500                 505                 510        
 Leu Ser Leu Gln Pro Pro Asp Met Ser Pro Gly Ala Pro Arg Asp Trp
         515                 520                 525            
 Val Trp Gly Gly Ser Gly Met Gly Val Gly Glu Arg Asp Arg Arg Pro
     530                 535                 540                
 Arg Leu Lys Phe His Ser Cys Trp His Ala Glu Ser Ser Gly Leu Trp
 545                 550                 555                 560
 Glu Gly Gly Val Ala Val Ser Ile Ser Leu
                 565                 570



      <210> 326
      <211> 92
      <212> PRT
      <213> Homo sapiens


      <400> 326
 Met Ser Phe Ser Arg Lys Lys Lys Lys Lys Asp Lys Asp Lys Ala Lys
   1               5                  10                  15    
 Leu Leu Glu Ala Met Gly Thr Ser Lys Lys Asn Glu Glu Glu Lys Arg
              20                  25                  30        
 Arg Gly Leu Asp Lys Arg Thr Pro Ala Gln Ala Ala Phe Glu Lys Met
          35                  40                  45            
 Gln Glu Lys Arg Gln Met Glu Arg Ile Leu Lys Lys Ala Ser Lys Thr
      50                  55                  60                
 His Lys Gln Arg Val Glu Asp Phe Asn Arg His Leu Asp Thr Leu Thr
  65                  70                  75                  80
 Glu His Tyr Asp Ile Pro Lys Val Ser Trp Thr Lys
                  85                  90        



      <210> 327
      <211> 244
      <212> PRT
      <213> Homo sapiens


      <400> 327
 Met Asp Ile Leu Val Pro Leu Leu Gln Leu Leu Val Leu Leu Leu Thr
   1               5                  10                  15    
 Leu Pro Leu His Leu Met Ala Leu Leu Gly Cys Trp Gln Pro Leu Cys
              20                  25                  30        
 Lys Ser Tyr Phe Pro Tyr Leu Met Ala Val Leu Thr Pro Lys Ser Asn
          35                  40                  45            
 Arg Lys Met Glu Ser Lys Lys Arg Glu Leu Phe Ser Gln Ile Lys Gly
      50                  55                  60                
 Leu Thr Gly Ala Ser Gly Lys Val Ala Leu Leu Glu Leu Gly Cys Gly
  65                  70                  75                  80
 Thr Gly Ala Asn Phe Gln Phe Tyr Pro Pro Gly Cys Arg Val Thr Cys
                  85                  90                  95    
 Leu Asp Pro Asn Pro His Phe Glu Lys Phe Leu Thr Lys Ser Met Ala
             100                 105                 110        
 Glu Asn Arg His Leu Gln Tyr Glu Arg Phe Val Val Ala Pro Gly Glu
         115                 120                 125            
 Asp Met Arg Gln Leu Ala Asp Gly Ser Met Asp Val Val Val Cys Thr
     130                 135                 140                
 Leu Val Leu Cys Ser Val Gln Ser Pro Arg Lys Val Leu Gln Glu Val
 145                 150                 155                 160
 Arg Arg Val Leu Arg Pro Gly Gly Val Leu Phe Phe Trp Glu His Val
                 165                 170                 175    
 Ala Glu Pro Tyr Gly Ser Trp Ala Phe Met Trp Gln Gln Val Phe Glu
             180                 185                 190        
 Pro Thr Trp Lys His Ile Gly Asp Gly Cys Cys Leu Thr Arg Glu Thr
         195                 200                 205            
 Trp Lys Asp Leu Glu Asn Ala Gln Phe Ser Glu Ile Gln Met Glu Arg
     210                 215                 220                
 Gln Pro Pro Pro Leu Lys Trp Leu Pro Asp Gly His His Ile Met Gly
 225                 230                 235                 240
 Lys Ala Val Lys
                



      <210> 328
      <211> 764
      <212> PRT
      <213> Homo sapiens


      <400> 328
 Met Thr Cys Leu Arg Thr Gly Thr Glu Gly Ala Gln Gly Gly Val Gly
   1               5                  10                  15    
 Arg Gly Thr Gln Ala Gly Gly Pro Gly Gly Ala Pro Ser Leu Thr Pro
              20                  25                  30        
 Glu Ala Ala Gly Ala Ala Arg Arg Glu Asp Thr Ser Gly Pro Ser Val
          35                  40                  45            
 Pro Leu Ser Phe Pro Ala Ala Arg Cys Pro Arg Lys Val Pro Gly Leu
      50                  55                  60                
 Pro Pro Leu Gly Leu Leu Glu Ser Phe Gly Gly Cys Arg Ala Leu Ala
  65                  70                  75                  80
 Ala Arg Arg Gln Ala Ser Arg Gly Ala Gly Thr Ala Ala Gly Ser Gly
                  85                  90                  95    
 Arg Ala Arg Leu Glu Cys Ser Val Gln Asp Ala Arg Thr Gly Pro Ala
             100                 105                 110        
 Arg Asn Pro Arg Pro Arg Ala Ser Pro Pro Ala Leu Thr Arg Pro Val
         115                 120                 125            
 Arg Lys Ala Asp Arg Ala Gly Asp Ala Asn Leu Arg Pro Ala Pro Ser
     130                 135                 140                
 Asp Ser Lys Phe Ser His Trp Ser Arg Asp Pro Ala Arg His Gly Asn
 145                 150                 155                 160
 Arg Arg Arg Leu Gly Gly Cys Ala Glu Met Thr Ala Cys His Trp Ala
                 165                 170                 175    
 Ser Gly Met Ser Val Pro Ala Asp Asp Arg Pro Pro Arg Gly Gly Ala
             180                 185                 190        
 Ala Ala Pro His Leu Pro Glu Pro Leu Arg Arg Arg Trp Gln Gly Thr
         195                 200                 205            
 Arg Asp Arg Ser Leu Pro Ala Asp Leu Arg Glu His Pro Pro Thr Ile
     210                 215                 220                
 Gln Pro Arg Ala Gly Thr Gly Arg Ala Gly Ala Pro Ser Pro Asp Ser
 225                 230                 235                 240
 Gly Arg Val Ala Ser Ala Thr Thr Pro Ser Ser Gln Val Ser Phe Phe
                 245                 250                 255    
 Ser Ala Cys Tyr Ser Leu Arg Ala Ala Arg Arg Ser Leu Leu Ser Thr
             260                 265                 270        
 Ser Asn Cys Ile Leu His Ala Ser Arg Glu Arg Glu Phe Cys Cys Tyr
         275                 280                 285            
 Pro His Phe Thr Val Gly Lys Gln Pro Gln Arg Gly Ser His Leu Leu
     290                 295                 300                
 Glu His Ser Arg Leu Thr Leu Gly Pro Gly Gly Ser Leu Ile Leu Thr
 305                 310                 315                 320
 Pro Leu Gly Pro Arg Ser Gly Glu Thr Met Glu Gly Ala Ala Glu Ser
                 325                 330                 335    
 Pro Lys Ala Ala Gly Ser Gly Ser Ala Gln Thr Pro Ala Gln Pro Glu
             340                 345                 350        
 Ala Leu Ala Gln Pro Arg Gly Arg Gly Ala Arg Arg Trp Gln Pro Pro
         355                 360                 365            
 Ser Asp Ser Ala Pro Ser Gln Arg Asp Ala Gly Met Arg Arg Ala Ala
     370                 375                 380                
 Pro Pro Leu Ala Ala Arg Pro Asn Gly Glu Arg Ala Gly Phe Gly Leu
 385                 390                 395                 400
 Gly Gly Thr Gly Leu Ala Ala Val Ala Arg Gly Arg Gly Thr Arg Lys
                 405                 410                 415    
 Ser Ala Ala Val Ala Glu Ala Thr Ser Arg Pro Val Ser Ala Glu Pro
             420                 425                 430        
 Pro Cys Thr Thr Met Cys Ile Ile Phe Phe Lys Phe Asp Pro Arg Pro
         435                 440                 445            
 Val Ser Lys Asn Ala Tyr Arg Leu Ile Leu Ala Ala Asn Arg Asp Glu
     450                 455                 460                
 Phe Tyr Ser Arg Pro Ser Lys Leu Ala Asp Phe Trp Gly Asn Asn Asn
 465                 470                 475                 480
 Glu Ile Leu Ser Gly Leu Asp Met Glu Glu Gly Lys Glu Gly Gly Thr
                 485                 490                 495    
 Trp Leu Gly Ile Ser Thr Arg Gly Lys Leu Ala Ala Leu Thr Asn Tyr
             500                 505                 510        
 Leu Gln Pro Gln Leu Asp Trp Gln Ala Arg Gly Arg Gly Glu Leu Val
         515                 520                 525            
 Thr His Phe Leu Thr Thr Asp Val Asp Ser Leu Ser Tyr Leu Lys Lys
     530                 535                 540                
 Val Ser Met Glu Gly His Leu Tyr Asn Gly Phe Asn Leu Ile Ala Ala
 545                 550                 555                 560
 Asp Leu Ser Thr Ala Lys Gly Asp Val Ile Cys Tyr Tyr Gly Asn Arg
                 565                 570                 575    
 Gly Glu Pro Asp Pro Ile Val Leu Thr Pro Gly Thr Tyr Gly Leu Ser
             580                 585                 590        
 Asn Ala Leu Leu Glu Thr Pro Trp Arg Lys Leu Cys Phe Gly Lys Gln
         595                 600                 605            
 Leu Phe Leu Glu Ala Val Glu Arg Ser Gln Ala Leu Pro Lys Asp Val
     610                 615                 620                
 Leu Ile Ala Ser Leu Leu Asp Val Leu Asn Asn Glu Glu Ala Gln Leu
 625                 630                 635                 640
 Pro Asp Pro Ala Ile Glu Asp Gln Gly Gly Glu Tyr Val Gln Pro Met
                 645                 650                 655    
 Leu Ser Lys Tyr Ala Ala Val Cys Val Arg Cys Pro Gly Tyr Gly Thr
             660                 665                 670        
 Arg Tyr Cys Ser Thr Val Gly Ala Pro Pro Pro Ile Pro Cys Pro Thr
         675                 680                 685            
 Ser His Ala Arg Gly Pro Ala Lys Lys Pro Ser Ala His Ser Gln Ser
     690                 695                 700                
 Gln Ala Ser Ser Ser Pro Glu Trp Ile Pro Glu Leu Leu Pro Cys Pro
 705                 710                 715                 720
 Asp Ala Ala Ala Gly Thr Asn Thr Ile Ile Leu Val Asp Ala Asp Gly
                 725                 730                 735    
 His Val Thr Phe Thr Glu Arg Ser Met Met Asp Lys Asp Leu Ser His
             740                 745                 750        
 Trp Glu Thr Arg Thr Tyr Glu Phe Thr Leu Gln Ser
         755                 760                



      <210> 329
      <211> 329
      <212> PRT
      <213> Homo sapiens


      <400> 329
 Met Ser Gly Val Val Pro Thr Ala Pro Glu Gln Pro Ala Gly Glu Met
   1               5                  10                  15    
 Glu Asn Gln Thr Lys Pro Pro Asp Pro Arg Pro Asp Ala Pro Pro Glu
              20                  25                  30        
 Tyr Asn Ser His Phe Leu Pro Arg Pro Pro Gly Thr Ala Val Pro Pro
          35                  40                  45            
 Pro Thr Gly Tyr Pro Gly Gly Leu Pro Met Gly Tyr Tyr Ser Pro Gln
      50                  55                  60                
 Gln Pro Ser Thr Phe Pro Leu Tyr Gln Pro Val Gly Gly Ile His Pro
  65                  70                  75                  80
 Val Arg Tyr Gln Pro Gly Lys Tyr Pro Met Pro Asn Gln Ser Val Pro
                  85                  90                  95    
 Ile Thr Trp Met Pro Gly Pro Thr Pro Met Ala Asn Cys Pro Pro Gly
             100                 105                 110        
 Leu Glu Tyr Leu Val Gln Leu Asp Asn Ile His Val Leu Gln His Phe
         115                 120                 125            
 Glu Pro Leu Glu Met Met Thr Cys Phe Glu Thr Asn Asn Arg Tyr Asp
     130                 135                 140                
 Ile Lys Asn Asn Ser Asp Gln Met Val Tyr Val Val Thr Glu Asp Thr
 145                 150                 155                 160
 Asp Asp Phe Thr Arg Asn Ala Tyr Arg Thr Leu Arg Pro Phe Val Leu
                 165                 170                 175    
 Arg Val Thr Asp Cys Met Gly Arg Glu Ile Met Thr Met Gln Arg Pro
             180                 185                 190        
 Phe Arg Cys Thr Cys Cys Cys Phe Cys Cys Pro Ser Ala Arg Gln Glu
         195                 200                 205            
 Leu Glu Val Gln Cys Pro Pro Gly Val Thr Ile Gly Phe Val Ala Glu
     210                 215                 220                
 His Trp Asn Leu Cys Arg Ala Val Tyr Ser Ile Gln Asn Glu Lys Lys
 225                 230                 235                 240
 Glu Asn Val Met Arg Val Arg Gly Pro Cys Ser Thr Tyr Gly Cys Gly
                 245                 250                 255    
 Ser Asp Ser Val Phe Glu Val Lys Ser Leu Asp Gly Ile Ser Asn Ile
             260                 265                 270        
 Gly Ser Ile Ile Arg Lys Trp Asn Gly Leu Leu Ser Ala Met Ala Asp
         275                 280                 285            
 Ala Asp His Phe Asp Ile His Phe Pro Leu Asp Leu Asp Val Lys Met
     290                 295                 300                
 Lys Ala Met Ile Phe Gly Ala Cys Phe Leu Ile Asp Phe Met Tyr Phe
 305                 310                 315                 320
 Glu Arg Ser Pro Pro Gln Arg Ser Arg
                 325                



      <210> 330
      <211> 119
      <212> PRT
      <213> Homo sapiens


      <400> 330
 Met Val Lys Met Thr Lys Ser Lys Thr Phe Gln Ala Tyr Leu Pro Asn
   1               5                  10                  15    
 Cys His Arg Thr Tyr Ser Cys Ile His Cys Arg Ala His Leu Ala Asn
              20                  25                  30        
 His Asp Glu Leu Ile Ser Lys Ser Phe Gln Gly Ser Gln Gly Arg Ala
          35                  40                  45            
 Tyr Leu Phe Asn Ser Val Val Asn Val Gly Cys Gly Pro Ala Glu Glu
      50                  55                  60                
 Arg Val Leu Leu Thr Gly Leu His Ala Val Ala Asp Ile Tyr Cys Glu
  65                  70                  75                  80
 Asn Cys Lys Thr Thr Leu Gly Trp Lys Tyr Glu His Ala Phe Glu Ser
                  85                  90                  95    
 Ser Gln Lys Tyr Lys Glu Gly Lys Phe Ile Ile Glu Leu Ala His Met
             100                 105                 110        
 Ile Lys Asp Asn Gly Trp Glu
         115                



      <210> 331
      <211> 1982
      <212> PRT
      <213> Homo sapiens


      <400> 331
 Met Glu Glu Arg Leu Gly Arg Leu Leu Pro Ala Asp Trp Gly Val Gly
   1               5                  10                  15    
 Gly Thr Ala Glu Gly Gly Gly Gly Ala Ala Cys Arg Arg Cys Cys Leu
              20                  25                  30        
 Arg Cys Trp Ala Pro Gly Gln Leu Pro Gly Thr Leu Arg Pro Pro Trp
          35                  40                  45            
 Thr Ser Arg Arg Val Thr Ala Ser Ser Ser Ala Thr Thr Thr Arg Ala
      50                  55                  60                
 Pro Arg Cys Lys Val Leu Trp Ala Leu Arg Ser Ala Ala Ala Ala Ala
  65                  70                  75                  80
 Thr Gly Ala Ala Trp Tyr Ala Ser Leu Pro Asp Val Gln Cys Leu Glu
                  85                  90                  95    
 Asn Cys Cys Phe Ile Tyr Phe Val Glu Phe Phe Gly Tyr Leu Arg Arg
             100                 105                 110        
 Gly Glu Leu Gln Asn Glu Ala Val Phe Met Trp Thr Ala Glu Leu Glu
         115                 120                 125            
 Asn Ile Ala Thr Leu Cys Phe Lys Ala Leu Glu Asn Ser Asn Tyr Gly
     130                 135                 140                
 Val Arg Val Ala Val Ser Lys Leu Leu Gly Thr Val Met Ala Thr Ala
 145                 150                 155                 160
 Leu Met Pro Lys Gln Ala Thr Val Met Arg Gln Asn Val Lys Arg Ala
                 165                 170                 175    
 Thr Phe Asp Glu Val Leu Glu Leu Met Ala Thr Gly Phe Leu Arg Gly
             180                 185                 190        
 Gly Ser Gly Phe Leu Lys Ser Gly Gly Glu Met Leu Lys Val Gly Gly
         195                 200                 205            
 Ser Val Asn Arg Glu Val Arg Val Gly Val Thr Gln Ala Tyr Val Val
     210                 215                 220                
 Phe Val Thr Thr Leu Gly Gly Gln Trp Leu Glu Arg Ser Phe Ala Thr
 225                 230                 235                 240
 Phe Leu Ser His Val Leu Asp Leu Val Ser His Pro Arg Ala Thr Gln
                 245                 250                 255    
 Thr His Val Glu Ala Val Tyr Ser Arg Arg Cys Val Ser Phe Ile Leu
             260                 265                 270        
 Arg Ala Thr Val Gly Ser Leu Leu Gly Glu Lys Ala Gln Ile Ala Ala
         275                 280                 285            
 Ala Lys Glu Ile Cys Gln Ala Ile Gly Lys Gln Met Lys Ala Val Glu
     290                 295                 300                
 Ala Val Val Asn Asp Thr Ser Gly Glu Asn Lys Phe Gly Ala Ala Asp
 305                 310                 315                 320
 Ile Ala Ala Ser Gln His Val Met Val Cys Ala Leu Gln Glu Leu Gly
                 325                 330                 335    
 Ser Leu Val Gln Ser Leu Asn Ala Thr Ala Ser Pro Leu Ile Gln Glu
             340                 345                 350        
 Ala Ser Ile Gly Leu Leu Glu Ile Val Thr Ser Val Leu Leu His Pro
         355                 360                 365            
 Ser Met Ala Ala Arg Leu Ala Ala Ala Trp Cys Leu Arg Cys Val Ala
     370                 375                 380                
 Val Ala Leu Pro Phe Gln Leu Thr Pro Phe Leu Asp Arg Cys Ala Glu
 385                 390                 395                 400
 Arg Leu Asn Asn Leu Lys Thr Ser Pro Glu Ala Val Ser Gly Tyr Ser
                 405                 410                 415    
 Phe Ala Met Ala Ala Leu Leu Gly Gly Val His Gln Cys Pro Leu Gly
             420                 425                 430        
 Ile Pro His Ala Lys Gly Lys Met Val Val Ser Ile Ala Glu Asp Leu
         435                 440                 445            
 Leu Arg Thr Ala Ala Gln Asn Ser Arg Leu Ser Leu Gln Arg Thr Gln
     450                 455                 460                
 Ala Gly Trp Leu Leu Leu Gly Ala Leu Met Thr Leu Gly Pro Ser Val
 465                 470                 475                 480
 Val Arg Tyr His Leu Pro Lys Met Leu Leu Leu Trp Arg Asn Val Phe
                 485                 490                 495    
 Pro Arg Ser Leu Lys Glu Leu Glu Ala Glu Lys Ala Arg Gly Asp Ser
             500                 505                 510        
 Phe Thr Trp Gln Val Thr Leu Glu Gly Arg Ala Gly Ala Leu Cys Ala
         515                 520                 525            
 Met Arg Ser Phe Val Ala His Cys Pro Glu Leu Leu Thr Glu Asp Val
     530                 535                 540                
 Ile Arg Lys Leu Met Thr Pro Ile Glu Cys Ala Met Thr Met Met Ser
 545                 550                 555                 560
 His Ile Pro Ser Val Met Lys Ala His Gly Ala His Leu Lys Ala Ser
                 565                 570                 575    
 Ala Ala Met Val Arg Leu Arg Leu Tyr Asp Ile Leu Ala Leu Leu Pro
             580                 585                 590        
 Pro Lys Thr Tyr Glu Gly Ser Phe Asn Ala Leu Leu Arg Glu Leu Val
         595                 600                 605            
 Ala Glu Phe Thr Leu Thr Asp Asn Ser Ala Asn Thr Thr Thr Ser Leu
     610                 615                 620                
 Leu Arg Ser Leu Cys His Tyr Asp Asp Ser Val Leu Leu Gly Ser Trp
 625                 630                 635                 640
 Leu Gln Glu Thr Asp His Lys Ser Ile Glu Asp Gln Leu Gln Pro Asn
                 645                 650                 655    
 Ser Ala Ser Gly Ser Gly Ala Leu Glu His Asp Pro Ser Ser Ile Tyr
             660                 665                 670        
 Leu Arg Ile Pro Ala Gly Glu Ala Val Pro Gly Pro Leu Pro Leu Gly
         675                 680                 685            
 Val Ser Val Ile Asp Ala Ser Val Ala Leu Phe Gly Val Val Phe Pro
     690                 695                 700                
 His Val Ser Tyr Lys His Arg Leu Gln Met Leu Asp His Phe Ala Glu
 705                 710                 715                 720
 Cys Val Lys Gln Ala Lys Gly Val Arg Gln Gln Ala Val Gln Leu Asn
                 725                 730                 735    
 Ile Phe Thr Ala Val Leu Ser Ala Leu Lys Gly Leu Ala Glu Asn Lys
             740                 745                 750        
 Ser Thr Leu Gly Pro Glu Glu Val Arg Lys Ser Ala Leu Thr Leu Val
         755                 760                 765            
 Met Gly Pro Leu Asp Asn Pro Asn Pro Ile Leu Arg Cys Ala Ala Gly
     770                 775                 780                
 Glu Ala Leu Gly Arg Met Ala Gln Val Val Gly Glu Ala Thr Phe Ile
 785                 790                 795                 800
 Ala Arg Met Ala Gln Tyr Ser Phe Asp Lys Leu Lys Ser Ala Arg Asp
                 805                 810                 815    
 Val Val Ser Arg Thr Gly His Ser Leu Ala Leu Gly Cys Leu His Arg
             820                 825                 830        
 Tyr Val Gly Gly Ile Gly Ser Gly Gln His Leu Lys Thr Ser Val Ser
         835                 840                 845            
 Ile Leu Leu Ala Leu Ala Gln Asp Gly Thr Ser Pro Glu Val Gln Thr
     850                 855                 860                
 Trp Ser Leu His Ser Leu Ala Leu Ile Val Asp Ser Ser Gly Pro Met
 865                 870                 875                 880
 Tyr Arg Gly Tyr Val Glu Pro Thr Leu Ser Leu Val Leu Thr Leu Leu
                 885                 890                 895    
 Leu Thr Val Pro Pro Ser His Thr Glu Val His Gln Cys Leu Gly Arg
             900                 905                 910        
 Cys Leu Gly Ala Ile Ile Thr Thr Val Gly Pro Glu Leu Gln Gly Asn
         915                 920                 925            
 Gly Ala Thr Thr Ser Thr Ile Arg Ser Ser Cys Leu Val Gly Cys Ala
     930                 935                 940                
 Ile Thr Gln Asp His Ser Asp Ser Leu Val Gln Ala Ala Ala Ile Ser
 945                 950                 955                 960
 Cys Leu Gln Gln Leu His Met Phe Ala Pro Arg His Val Asn Leu Ser
                 965                 970                 975    
 Ser Leu Val Pro Ser Leu Cys Val His Leu Cys Ser Ser His Leu Leu
             980                 985                 990        
 Leu Arg Arg Ala Ala Val Ala Cys Leu Arg Gln Leu Ala Gln Arg Glu
         995                1000                1005            
 Ala Ala Glu Val Cys Glu Tyr Ala Met Ser Leu Ala Lys Asn Thr Gly
    1010                1015                1020                
 Asp Lys Glu Ser Ser Ser Ala Asn Val Ser Pro Phe Ala Pro Gly Val
1025                1030                1035                1040
 Ser Ser Arg Thr Asp Ile His Cys Arg His Gln Gly Val Asn Ile Thr
                1045                1050                1055    
 Glu Thr Gly Leu Glu Gly Leu Leu Phe Gly Met Leu Asp Arg Glu Thr
            1060                1065                1070        
 Asp Arg Lys Leu Cys Ser Asp Ile His Asp Thr Leu Gly His Met Leu
        1075                1080                1085            
 Ser Ser Leu Ala Val Glu Lys Leu Ser His Trp Leu Met Leu Cys Lys
    1090                1095                1100                
 Asp Val Leu Ala Ala Ser Ser Asp Met Ser Thr Ala Thr Leu Leu Ser
1105                1110                1115                1120
 Ser Gly Lys Asp Glu Glu Ala Glu Lys Lys Asp Glu Met Asp Asp Asp
                1125                1130                1135    
 Thr Met Phe Thr Thr Leu Gly Glu Glu Asp Lys Ser Lys Pro Phe Val
            1140                1145                1150        
 Ala Pro Arg Trp Ala Thr Arg Val Phe Ala Ala Asp Cys Leu Cys Arg
        1155                1160                1165            
 Ile Ile Asn Leu Cys Glu Asn Ala Asp Gln Ala His Phe Asp Leu Ala
    1170                1175                1180                
 Leu Ala Arg Ser Ala Lys Leu Arg Asn Pro Thr Asn Asp Leu Leu Val
1185                1190                1195                1200
 Leu His Leu Ser Asp Leu Ile Arg Met Ala Phe Met Ala Ala Thr Asp
                1205                1210                1215    
 His Ser Asn Gln Leu Arg Met Ala Gly Leu Gln Ala Leu Glu Asp Ile
            1220                1225                1230        
 Ile Lys Lys Phe Ala Ser Val Pro Glu Pro Glu Phe Pro Gly His Val
        1235                1240                1245            
 Ile Leu Glu Gln Tyr Gln Ala Asn Val Gly Ala Ala Leu Arg Pro Ala
    1250                1255                1260                
 Phe Ser Gln Asp Thr Pro Ser Asp Ile Ile Ala Lys Ala Cys Gln Val
1265                1270                1275                1280
 Cys Ser Thr Trp Ile Gly Ser Gly Val Val Ser Asp Leu Asn Asp Leu
                1285                1290                1295    
 Arg Arg Val His Asn Leu Leu Val Ser Ser Leu Asp Lys Val Gln Ala
            1300                1305                1310        
 Gly Lys Gly Ser Ser Ser Gln Leu Tyr Arg Glu Ser Ala Thr Thr Met
        1315                1320                1325            
 Glu Lys Leu Ala Val Leu Lys Ala Trp Ala Glu Val Tyr Val Val Ala
    1330                1335                1340                
 Met Asn Ile Lys Lys Glu Ala Glu Ser Lys Pro Lys Arg Ala Ile Lys
1345                1350                1355                1360
 Asn Thr Asp Asp Asp Asp Asp Asp Cys Gly Thr Ile Asp Glu Leu Pro
                1365                1370                1375    
 Pro Asp Ser Leu Ile Thr Leu Val Gln Pro Glu Leu Pro Thr Leu Ser
            1380                1385                1390        
 Arg Leu Trp Leu Ala Ala Leu Lys Asp Tyr Ala Leu Leu Thr Leu Pro
        1395                1400                1405            
 Ala Glu Phe Ser Ser Gln Leu Pro Pro Asp Gly Gly Ala Phe Tyr Thr
    1410                1415                1420                
 Pro Glu Thr Ile Asp Thr Ala Arg Leu His Tyr Arg Asn Ser Trp Ala
1425                1430                1435                1440
 Pro Ile Leu His Ala Val Ala Leu Trp Leu Asn Ser Thr Gly Phe Thr
                1445                1450                1455    
 Cys Ser Glu Ser Thr Glu Ala Ala Ala Ile Ser Gly Leu Gln Lys Arg
            1460                1465                1470        
 Ser Thr Ser Val Asn Leu Asn Gln Ala Ser Gly Ala Val Gly Ser Ala
        1475                1480                1485            
 Lys Ser Leu Pro Glu Ile Asn Lys Asp Arg Met His Leu Ile Leu Gly
    1490                1495                1500                
 Val Ser Ile Gln Phe Leu Cys Ser Pro Arg Pro Glu Glu Pro Ile Glu
1505                1510                1515                1520
 His Val Thr Ala Cys Leu Gln Ala Leu His Thr Leu Leu Asp Ser Pro
                1525                1530                1535    
 Tyr Ala Arg Val His Ile Ala Glu Asp Gln Leu Ile Gly Val Glu Leu
            1540                1545                1550        
 Leu Ser Val Leu His Arg Leu Leu Leu Thr Trp Asn Pro Ser Ser Val
        1555                1560                1565            
 Gln Leu Leu Val Thr Gly Val Val Gln Gln Ile Val Arg Ala Ala Gln
    1570                1575                1580                
 Asp Tyr Leu Gln Glu Lys Arg Asn Thr Leu Asn Glu Asp Asp Met Glu
1585                1590                1595                1600
 Lys Glu Ala Cys Thr Val Leu Gly Glu Gly Gly Asp Ser Gly Gly Leu
                1605                1610                1615    
 Ile Pro Gly Lys Ser Leu Val Phe Ala Thr Met Glu Leu Leu Met Phe
            1620                1625                1630        
 Ile Leu Val Arg His Met Pro His Leu Ser Thr Lys Val Ser Asp Ser
        1635                1640                1645            
 Pro Ser His Ile Ala Thr Lys Thr Arg Leu Ser Glu Glu Ser Ala Arg
    1650                1655                1660                
 Leu Val Ala Ala Thr Val Thr Ile Leu Ser Asp Leu Pro Ser Leu Cys
1665                1670                1675                1680
 Ser Pro Ala Gly Cys Met Thr Ile Leu Pro Thr Ile Leu Phe Leu Ile
                1685                1690                1695    
 Ala Arg Ile Leu Lys Asp Thr Ala Ile Lys Ser Ala Asp Asn Gln Val
            1700                1705                1710        
 Pro Pro Pro Val Ser Ala Ala Leu Gln Gly Ile Lys Ser Ile Val Thr
        1715                1720                1725            
 Leu Ser Met Ala Lys Thr Glu Ala Gly Val Gln Lys Gln Trp Thr Ala
    1730                1735                1740                
 Leu Ile Arg Ser Thr Leu Ala Cys Ile Leu Glu Tyr Ser Gln Pro Glu
1745                1750                1755                1760
 Asp Ser Val Pro Thr Pro Asp Glu Val Ser Met Leu Thr Ala Ile Ala
                1765                1770                1775    
 Leu Phe Leu Trp Ser Ala Ser Asn Glu Ile Ile Gly Val Gln Ser Leu
            1780                1785                1790        
 Gln Asn Gly Cys Met Asn Arg Phe Lys Asn Ala Leu Asn Ser Cys Asp
        1795                1800                1805            
 Pro Trp Val Gln Ala Lys Cys Tyr Gln Leu Leu Leu Ser Val Phe Gln
    1810                1815                1820                
 His Ser Asn Arg Ala Leu Ser Thr Pro Tyr Ile His Ser Leu Ala Pro
1825                1830                1835                1840
 Ile Val Val Glu Lys Leu Lys Ala Val Glu Arg Asn Arg Pro Ala Ser
                1845                1850                1855    
 Asn Ile Glu Leu Leu Ala Val Gln Glu Gly Ile Lys Val Leu Glu Thr
            1860                1865                1870        
 Leu Val Ala Leu Gly Glu Glu Gln Asn Arg Val Gln Leu Leu Ala Leu
        1875                1880                1885            
 Leu Val Pro Thr Leu Ile Ser Tyr Leu Leu Asp Glu Asn Ser Phe Ala
    1890                1895                1900                
 Ser Ala Ser Ser Ala Ser Lys Asp Leu His Glu Phe Ala Leu Gln Asn
1905                1910                1915                1920
 Leu Met His Ile Gly Pro Leu Tyr Pro His Ala Phe Lys Thr Val Met
                1925                1930                1935    
 Gly Ala Ala Pro Glu Leu Lys Val Arg Leu Glu Thr Ala Val Arg Ala
            1940                1945                1950        
 Ser Gln Ala Ser Lys Ala Lys Ala Ala Ala Arg Gln Pro Ala Pro Ala
        1955                1960                1965            
 Ile His Ser Ala Pro Thr Ile Lys Leu Lys Thr Ser Phe Phe
    1970                1975                1980        



      <210> 332
      <211> 640
      <212> PRT
      <213> Homo sapiens


      <400> 332
 Met Leu Arg Ser Thr Leu Ala Gln Gln Gly Thr Pro Val Tyr Ser Val
   1               5                  10                  15    
 Ala Trp Gly Pro Asp Ser Glu Lys Val Leu Tyr Thr Ala Gly Lys Gln
              20                  25                  30        
 Leu Ile Ile Lys Pro Leu Gln Pro Asn Ala Lys Val Leu Gln Trp Lys
          35                  40                  45            
 Ala His Asp Gly Ile Ile Leu Lys Val Asp Trp Asn Ser Val Asn Asp
      50                  55                  60                
 Leu Ile Leu Ser Ala Gly Glu Asp Cys Lys Tyr Lys Val Trp Asp Ser
  65                  70                  75                  80
 Tyr Gly Arg Pro Leu Tyr Asn Ser Gln Pro His Glu His Pro Ile Thr
                  85                  90                  95    
 Ser Val Ala Trp Ala Pro Asp Gly Glu Leu Phe Ala Val Gly Ser Phe
             100                 105                 110        
 His Thr Leu Arg Leu Cys Asp Lys Thr Gly Trp Ser Tyr Ala Leu Glu
         115                 120                 125            
 Lys Pro Asn Thr Gly Ser Ile Phe Asn Ile Ala Trp Ser Ile Asp Gly
     130                 135                 140                
 Thr Gln Ile Ala Gly Ala Cys Gly Asn Gly His Val Val Phe Ala His
 145                 150                 155                 160
 Val Val Glu Gln His Trp Glu Trp Lys Asn Phe Gln Val Thr Leu Thr
                 165                 170                 175    
 Lys Arg Arg Ala Met Gln Val Arg Asn Val Leu Asn Asp Ala Val Asp
             180                 185                 190        
 Leu Leu Glu Phe Arg Asp Arg Val Ile Lys Ala Ser Leu Asn Tyr Ala
         195                 200                 205            
 His Leu Val Val Ser Thr Ser Leu Gln Cys Tyr Val Phe Ser Thr Lys
     210                 215                 220                
 Asn Trp Asn Thr Pro Ile Ile Phe Asp Leu Lys Glu Gly Thr Val Ser
 225                 230                 235                 240
 Leu Ile Leu Gln Ala Glu Arg His Phe Leu Leu Val Asp Gly Ser Ser
                 245                 250                 255    
 Ile Tyr Leu Tyr Ser Tyr Glu Gly Arg Phe Ile Ser Ser Pro Lys Phe
             260                 265                 270        
 Pro Gly Met Arg Thr Asp Ile Leu Asn Ala Gln Thr Val Ser Leu Ser
         275                 280                 285            
 Asn Asp Thr Ile Ala Ile Arg Asp Lys Ala Asp Glu Lys Ile Ile Phe
     290                 295                 300                
 Leu Phe Glu Ala Ser Thr Gly Lys Pro Leu Gly Asp Gly Lys Phe Leu
 305                 310                 315                 320
 Ser His Lys Asn Glu Ile Leu Glu Ile Ala Leu Asp Gln Lys Gly Leu
                 325                 330                 335    
 Thr Asn Asp Arg Lys Ile Ala Phe Ile Asp Lys Asn Arg Asp Leu Cys
             340                 345                 350        
 Ile Thr Ser Val Lys Arg Phe Gly Lys Glu Glu Gln Ile Ile Lys Leu
         355                 360                 365            
 Gly Thr Met Val His Thr Leu Ala Trp Asn Asp Thr Cys Asn Ile Leu
     370                 375                 380                
 Cys Gly Leu Gln Asp Thr Arg Phe Ile Val Trp Tyr Tyr Pro Asn Thr
 385                 390                 395                 400
 Val Tyr Val Asp Arg Asp Ile Leu Pro Lys Thr Leu Tyr Glu Arg Asp
                 405                 410                 415    
 Ala Ser Glu Phe Ser Lys Asn Pro His Ile Val Ser Phe Val Gly Asn
             420                 425                 430        
 Gln Val Thr Ile Arg Arg Ala Asp Gly Ser Leu Val His Ile Ser Ile
         435                 440                 445            
 Thr Pro Tyr Pro Ala Ile Leu His Glu Tyr Val Ser Ser Ser Lys Trp
     450                 455                 460                
 Glu Asp Ala Val Arg Leu Cys Arg Phe Val Lys Glu Gln Thr Met Trp
 465                 470                 475                 480
 Ala Cys Leu Ala Ala Met Ala Val Ala Asn Arg Asp Met Thr Thr Ala
                 485                 490                 495    
 Glu Ile Ala Tyr Ala Ala Ile Gly Glu Ile Asp Lys Val Gln Tyr Ile
             500                 505                 510        
 Asn Ser Ile Lys Asn Leu Pro Ser Lys Glu Ser Lys Met Ala His Ile
         515                 520                 525            
 Leu Leu Phe Ser Gly Asn Ile Gln Glu Ala Glu Ile Val Leu Leu Gln
     530                 535                 540                
 Ala Gly Leu Val Tyr Gln Ala Ile Gln Ile Asn Ile Asn Leu Tyr Asn
 545                 550                 555                 560
 Trp Glu Arg Ala Leu Glu Leu Ala Val Lys Tyr Lys Thr His Val Asp
                 565                 570                 575    
 Thr Val Leu Ala Tyr Arg Gln Lys Phe Leu Glu Thr Phe Gly Lys Gln
             580                 585                 590        
 Glu Thr Asn Lys Arg Tyr Leu His Tyr Ala Glu Gly Leu Gln Ile Asp
         595                 600                 605            
 Trp Glu Lys Ile Lys Ala Lys Ile Glu Met Glu Ile Thr Lys Glu Arg
     610                 615                 620                
 Glu Gln Ser Ser Ser Ser Gln Ser Ser Lys Ser Ile Gly Leu Lys Pro
 625                 630                 635                 640





      <210> 333
      <211> 126
      <212> PRT
      <213> Homo sapiens


      <400> 333
 Met Ala Pro Gly Glu Val Thr Ile Thr Val Arg Leu Ile Arg Ser Phe
   1               5                  10                  15    
 Glu His Arg Asn Phe Lys Pro Val Val Tyr His Gly Val Asn Leu Asp
              20                  25                  30        
 Gln Thr Val Lys Glu Phe Ile Val Phe Leu Lys Gln Asp Val Pro Leu
          35                  40                  45            
 Arg Thr Asn Leu Pro Pro Pro Phe Arg Asn Tyr Lys Tyr Asp Ala Leu
      50                  55                  60                
 Lys Ile Ile His Gln Ala His Lys Ser Lys Thr Asn Glu Leu Val Leu
  65                  70                  75                  80
 Ser Leu Glu Asp Asp Glu Arg Leu Leu Leu Lys Glu Asp Ser Thr Leu
                  85                  90                  95    
 Lys Ala Ala Gly Ile Ala Ser Glu Thr Glu Ile Ala Phe Phe Cys Glu
             100                 105                 110        
 Glu Asp Tyr Arg Asn Tyr Lys Ala Asn Pro Ile Ser Ser Trp
         115                 120                 125    



      <210> 334
      <211> 467
      <212> PRT
      <213> Homo sapiens


      <400> 334
 Met Asp Glu Gly Gly Thr Pro Leu Leu Pro Asp Ser Leu Val Tyr Gln
   1               5                  10                  15    
 Ile Phe Leu Ser Leu Gly Pro Ala Asp Val Leu Ala Ala Gly Leu Val
              20                  25                  30        
 Cys Arg Gln Trp Gln Ala Val Ser Arg Asp Glu Phe Leu Trp Arg Glu
          35                  40                  45            
 Gln Phe Tyr Arg Tyr Tyr Gln Val Ala Arg Asp Val Pro Arg His Pro
      50                  55                  60                
 Ala Ala Met Ser Trp Tyr Glu Glu Phe Gln Arg Leu Tyr Asp Thr Val
  65                  70                  75                  80
 Pro Cys Val Glu Val Gln Thr Leu Arg Glu His Thr Asp Gln Val Leu
                  85                  90                  95    
 His Leu Ser Phe Ser His Ser Gly Tyr Gln Phe Ala Ser Cys Ser Lys
             100                 105                 110        
 Asp Cys Thr Val Lys Ile Trp Ser Asn Asp Leu Thr Ile Ser Leu Leu
         115                 120                 125            
 His Ser Ala Asp Met Arg Pro Tyr Asn Trp Ser Tyr Thr Gln Phe Ser
     130                 135                 140                
 Gln Phe Asn Lys Asp Asp Ser Leu Leu Leu Ala Ser Gly Val Phe Leu
 145                 150                 155                 160
 Gly Pro His Asn Ser Ser Ser Gly Glu Ile Ala Val Ile Ser Leu Asp
                 165                 170                 175    
 Ser Phe Ala Leu Leu Ser Arg Val Arg Asn Lys Pro Tyr Asp Val Phe
             180                 185                 190        
 Gly Cys Trp Leu Thr Glu Thr Ser Leu Ile Ser Gly Asn Leu His Arg
         195                 200                 205            
 Ile Gly Asp Ile Thr Ser Cys Ser Val Leu Trp Leu Asn Asn Ala Phe
     210                 215                 220                
 Gln Asp Val Glu Ser Glu Asn Val Asn Val Val Lys Arg Leu Phe Lys
 225                 230                 235                 240
 Ile Gln Asn Leu Asn Ala Ser Thr Val Arg Thr Val Met Val Ala Asp
                 245                 250                 255    
 Cys Ser Arg Phe Asp Ser Pro Asp Leu Leu Leu Glu Ala Gly Asp Pro
             260                 265                 270        
 Ala Thr Ser Pro Cys Arg Ile Phe Asp Leu Gly Ser Asp Asn Glu Glu
         275                 280                 285            
 Val Val Ala Gly Pro Ala Pro Ala His Ala Lys Glu Gly Leu Arg His
     290                 295                 300                
 Phe Leu Asp Arg Val Leu Glu Gly Arg Ala Gln Pro Gln Leu Ser Glu
 305                 310                 315                 320
 Arg Met Leu Glu Thr Lys Val Ala Glu Leu Leu Ala Gln Gly His Thr
                 325                 330                 335    
 Lys Pro Pro Glu Arg Ser Ala Thr Gly Ala Lys Ser Lys Tyr Leu Ile
             340                 345                 350        
 Phe Thr Thr Gly Cys Leu Thr Tyr Ser Pro His Gln Ile Gly Ile Lys
         355                 360                 365            
 Gln Ile Leu Pro His Gln Met Thr Thr Ala Gly Pro Val Leu Gly Glu
     370                 375                 380                
 Gly Arg Gly Ser Asp Ala Phe Phe Asp Ala Leu Asp His Val Ile Asp
 385                 390                 395                 400
 Ile His Gly His Ile Ile Gly Met Gly Leu Ser Pro Asp Asn Arg Trp
                 405                 410                 415    
 Ala Ser Cys Gln Cys Pro Arg Arg Gly Ala Arg Arg Arg Pro Thr Pro
             420                 425                 430        
 Ser Thr Val Pro Leu Ala Gln Val Pro Val Arg Glu Gln Pro Arg Leu
         435                 440                 445            
 Ala Gln Arg Cys Gly Gly Gly Arg Pro His Ala Ala Ala Thr Asn Arg
     450                 455                 460                
 Gly Gly Asp
 465        



      <210> 335
      <211> 722
      <212> PRT
      <213> Homo sapiens


      <400> 335
 Met Ser Ala Glu Ser Gly Pro Gly Thr Arg Leu Arg Asn Leu Pro Val
   1               5                  10                  15    
 Met Gly Asp Gly Leu Glu Thr Ser Gln Met Ser Thr Thr Gln Ala Gln
              20                  25                  30        
 Ala Gln Pro Gln Pro Ala Asn Ala Ala Ser Thr Asn Pro Pro Pro Pro
          35                  40                  45            
 Glu Thr Ser Asn Pro Asn Lys Pro Lys Arg Gln Thr Asn Gln Leu Gln
      50                  55                  60                
 Tyr Leu Leu Arg Val Val Leu Lys Thr Leu Trp Lys His Gln Phe Ala
  65                  70                  75                  80
 Trp Pro Phe Gln Gln Pro Val Asp Ala Val Lys Leu Asn Leu Pro Asp
                  85                  90                  95    
 Tyr Tyr Lys Ile Ile Lys Thr Pro Met Asp Met Gly Thr Ile Lys Lys
             100                 105                 110        
 Arg Leu Glu Asn Asn Tyr Tyr Trp Asn Ala Gln Glu Cys Ile Gln Asp
         115                 120                 125            
 Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile Tyr Asn Lys Pro Gly Asp
     130                 135                 140                
 Asp Ile Val Leu Met Ala Glu Ala Leu Glu Lys Leu Phe Leu Gln Lys
 145                 150                 155                 160
 Ile Asn Glu Leu Pro Thr Glu Glu Thr Glu Ile Met Ile Val Gln Ala
                 165                 170                 175    
 Lys Gly Arg Gly Arg Gly Arg Lys Glu Thr Gly Thr Ala Lys Pro Gly
             180                 185                 190        
 Val Ser Thr Val Pro Asn Thr Thr Gln Ala Ser Thr Pro Pro Gln Thr
         195                 200                 205            
 Gln Thr Pro Gln Pro Asn Pro Pro Pro Val Gln Ala Thr Pro His Pro
     210                 215                 220                
 Phe Pro Ala Val Thr Pro Asp Leu Ile Val Gln Thr Pro Val Met Thr
 225                 230                 235                 240
 Val Val Pro Pro Gln Pro Leu Gln Thr Pro Pro Pro Val Pro Pro Gln
                 245                 250                 255    
 Pro Gln Pro Pro Pro Ala Pro Ala Pro Gln Pro Val Gln Ser His Pro
             260                 265                 270        
 Pro Ile Ile Ala Ala Thr Pro Gln Pro Val Lys Thr Lys Lys Gly Val
         275                 280                 285            
 Lys Arg Lys Ala Asp Thr Thr Thr Pro Thr Thr Ile Asp Pro Ile His
     290                 295                 300                
 Glu Pro Pro Ser Leu Pro Pro Glu Pro Lys Thr Thr Lys Leu Gly Gln
 305                 310                 315                 320
 Arg Arg Glu Ser Ser Arg Pro Val Lys Pro Pro Lys Lys Asp Val Pro
                 325                 330                 335    
 Asp Ser Gln Gln His Pro Ala Pro Glu Lys Ser Ser Lys Val Ser Glu
             340                 345                 350        
 Gln Leu Lys Cys Cys Ser Gly Ile Leu Lys Glu Met Phe Ala Lys Lys
         355                 360                 365            
 His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro Val Asp Val Glu Ala
     370                 375                 380                
 Leu Gly Leu His Asp Tyr Cys Asp Ile Ile Lys His Pro Met Asp Met
 385                 390                 395                 400
 Ser Thr Ile Lys Ser Lys Leu Glu Ala Arg Glu Tyr Arg Asp Ala Gln
                 405                 410                 415    
 Glu Phe Gly Ala Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr
             420                 425                 430        
 Asn Pro Pro Asp His Glu Val Val Ala Met Ala Arg Lys Leu Gln Asp
         435                 440                 445            
 Val Phe Glu Met Arg Phe Ala Lys Met Pro Asp Glu Pro Glu Glu Pro
     450                 455                 460                
 Val Val Ala Val Ser Ser Pro Ala Val Pro Pro Pro Thr Lys Val Val
 465                 470                 475                 480
 Ala Pro Pro Ser Ser Ser Asp Ser Ser Ser Asp Ser Ser Ser Asp Ser
                 485                 490                 495    
 Asp Ser Ser Thr Asp Asp Ser Glu Glu Glu Arg Ala Gln Arg Leu Ala
             500                 505                 510        
 Glu Leu Gln Glu Gln Leu Lys Ala Val His Glu Gln Leu Ala Ala Leu
         515                 520                 525            
 Ser Gln Pro Gln Gln Asn Lys Pro Lys Lys Lys Glu Lys Asp Lys Lys
     530                 535                 540                
 Glu Lys Lys Lys Glu Lys His Lys Arg Lys Glu Glu Val Glu Glu Asn
 545                 550                 555                 560
 Lys Lys Ser Lys Ala Lys Glu Pro Pro Pro Lys Lys Thr Lys Lys Asn
                 565                 570                 575    
 Asn Ser Ser Asn Ser Asn Val Ser Lys Lys Glu Pro Ala Pro Met Lys
             580                 585                 590        
 Ser Lys Pro Pro Pro Thr Tyr Glu Ser Glu Glu Glu Asp Lys Cys Lys
         595                 600                 605            
 Pro Met Ser Tyr Glu Glu Lys Arg Gln Leu Ser Leu Asp Ile Asn Lys
     610                 615                 620                
 Leu Pro Gly Glu Lys Leu Gly Arg Val Val His Ile Ile Gln Ser Arg
 625                 630                 635                 640
 Glu Pro Ser Leu Lys Asn Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe
                 645                 650                 655    
 Glu Thr Leu Lys Pro Ser Thr Leu Arg Glu Leu Glu Arg Tyr Val Thr
             660                 665                 670        
 Ser Cys Leu Arg Lys Lys Arg Lys Pro Gln Ala Glu Lys Val Asp Val
         675                 680                 685            
 Ile Ala Gly Ser Ser Lys Met Lys Gly Phe Ser Ser Ser Glu Ser Glu
     690                 695                 700                
 Ser Ser Ser Glu Ser Ser Ser Ser Asp Ser Glu Asp Ser Glu Thr Gly
 705                 710                 715                 720
 Pro Ala
        



      <210> 336
      <211> 563
      <212> PRT
      <213> Homo sapiens


      <400> 336
 Met Thr Pro Asp Leu Leu Asn Phe Lys Lys Gly Trp Met Ser Ile Leu
   1               5                  10                  15    
 Asp Glu Pro Gly Glu Pro Pro Ser Pro Ser Leu Thr Thr Thr Ser Thr
              20                  25                  30        
 Ser Gln Trp Lys Lys His Trp Phe Val Leu Thr Asp Ser Ser Leu Lys
          35                  40                  45            
 Tyr Tyr Arg Asp Ser Thr Ala Glu Glu Ala Asp Glu Leu Asp Gly Glu
      50                  55                  60                
 Ile Asp Leu Arg Ser Cys Thr Asp Val Thr Glu Tyr Ala Val Gln Arg
  65                  70                  75                  80
 Asn Tyr Gly Phe Gln Ile His Thr Lys Asp Ala Val Tyr Thr Leu Ser
                  85                  90                  95    
 Ala Met Thr Ser Gly Ile Arg Arg Asn Trp Ile Glu Ala Leu Arg Lys
             100                 105                 110        
 Thr Val Arg Pro Thr Ser Ala Pro Asp Val Thr Lys Leu Ser Asp Ser
         115                 120                 125            
 Asn Lys Glu Asn Ala Leu His Ser Tyr Ser Thr Gln Lys Gly Pro Leu
     130                 135                 140                
 Lys Ala Gly Glu Gln Arg Ala Gly Ser Glu Val Ile Ser Arg Gly Gly
 145                 150                 155                 160
 Pro Arg Lys Ala Asp Gly Gln Arg Gln Ala Leu Asp Tyr Val Glu Leu
                 165                 170                 175    
 Ser Pro Leu Thr Gln Ala Ser Pro Gln Arg Ala Arg Thr Pro Ala Arg
             180                 185                 190        
 Thr Pro Asp Arg Leu Ala Lys Gln Glu Glu Leu Glu Arg Asp Leu Ala
         195                 200                 205            
 Gln Arg Ser Glu Glu Arg Arg Lys Trp Phe Glu Ala Thr Asp Ser Arg
     210                 215                 220                
 Thr Pro Glu Val Pro Ala Gly Glu Gly Pro Arg Arg Gly Leu Gly Ala
 225                 230                 235                 240
 Pro Leu Thr Glu Asp Gln Gln Asn Arg Leu Ser Glu Glu Ile Glu Lys
                 245                 250                 255    
 Lys Trp Gln Glu Leu Glu Lys Leu Pro Leu Arg Glu Asn Lys Arg Val
             260                 265                 270        
 Pro Leu Thr Ala Leu Leu Asn Gln Ser Arg Gly Glu Arg Arg Gly Pro
         275                 280                 285            
 Pro Ser Asp Gly His Glu Ala Leu Glu Lys Glu Val Gln Ala Leu Arg
     290                 295                 300                
 Ala Gln Leu Glu Ala Trp Arg Leu Gln Gly Glu Ala Pro Gln Ser Ala
 305                 310                 315                 320
 Leu Arg Ser Gln Glu Asp Gly His Ile Pro Pro Gly Tyr Ile Ser Gln
                 325                 330                 335    
 Glu Ala Cys Glu Arg Ser Leu Ala Glu Met Glu Ser Ser His Gln Gln
             340                 345                 350        
 Val Met Glu Glu Leu Gln Arg His His Glu Arg Glu Leu Gln Arg Leu
         355                 360                 365            
 Gln Gln Glu Lys Glu Trp Leu Leu Ala Glu Glu Thr Ala Ala Thr Ala
     370                 375                 380                
 Ser Ala Ile Glu Ala Met Lys Lys Ala Tyr Gln Glu Glu Leu Ser Arg
 385                 390                 395                 400
 Glu Leu Ser Lys Thr Arg Ser Leu Gln Gln Gly Pro Asp Gly Leu Arg
                 405                 410                 415    
 Lys Gln His Gln Ser Asp Val Glu Ala Leu Lys Arg Glu Leu Gln Val
             420                 425                 430        
 Leu Ser Glu Gln Tyr Ser Gln Lys Cys Leu Glu Ile Gly Ala Leu Met
         435                 440                 445            
 Arg Gln Ala Glu Glu Arg Glu His Thr Leu Arg Arg Cys Gln Gln Glu
     450                 455                 460                
 Gly Gln Glu Leu Leu Arg His Asn Gln Glu Leu His Gly Pro Pro Val
 465                 470                 475                 480
 Arg Gly Asp Arg Pro Ala Ala Arg Leu His Cys Leu Ala Gly His Gly
                 485                 490                 495    
 Gln Trp Leu Arg Ala Gln Gln Arg Ala Glu Phe Leu Arg Ala Arg Gly
             500                 505                 510        
 Ala Ala Ser Arg Lys Arg Lys Arg Thr Pro Val Pro Lys Glu Gly Gly
         515                 520                 525            
 Ala Val Pro Pro Gly Arg Ala Pro Asp Asp Ala Glu Gly Gln Ala Leu
     530                 535                 540                
 His Leu Gly Lys Val Pro Gly Arg Leu Cys Gly Ala Glu Pro His Gln
 545                 550                 555                 560
 Asp Thr Val
            



      <210> 337
      <211> 134
      <212> PRT
      <213> Homo sapiens


      <400> 337
 Met Val Cys Gly Leu Leu Val Ser Leu Asp Trp Leu Gly Asp Leu Gly
   1               5                  10                  15    
 Gln Tyr Leu Gln Ser Cys Cys Phe Cys Phe Ile Cys Lys Asn Tyr Asp
              20                  25                  30        
 Pro His Thr Pro Ala Ala Ala Gln Gly Thr Val Ile Phe Tyr Thr Cys
          35                  40                  45            
 Val Asp Val Phe Val His Ser Ser Trp Phe Ile Thr Pro Ile Thr Leu
      50                  55                  60                
 Cys Tyr Asn Val Gly Thr Leu Gln Ala Ser Glu Asn Gly Ile Ser Val
  65                  70                  75                  80
 Cys Asp Leu Leu Leu Pro His Phe Thr Cys Ser Thr Pro Asp Phe Asn
                  85                  90                  95    
 Leu Thr Val Ala His Lys Thr Leu Ile Pro Glu Arg Val Leu Pro His
             100                 105                 110        
 Thr Arg Lys Glu Glu Arg Cys Thr Glu Arg Pro Arg Ser Ile Trp Thr
         115                 120                 125            
 Asp Arg Pro Cys Trp Val
     130                



      <210> 338
      <211> 2041
      <212> PRT
      <213> Homo sapiens


      <400> 338
 Met Asp Ser Thr Asn Met Asp Ser Asn Leu Lys Pro Glu Glu Val Val
   1               5                  10                  15    
 His Lys Glu Lys Arg Arg Thr Lys Ser Leu Leu Glu Glu Lys Leu Val
              20                  25                  30        
 Leu Lys Ser Lys Ser Lys Thr Gln Gly Lys Gln Val Lys Val Val Glu
          35                  40                  45            
 Thr Glu Leu Gln Glu Gly Ala Thr Lys Gln Ala Thr Thr Pro Lys Pro
      50                  55                  60                
 Asp Lys Glu Lys Asn Thr Glu Glu Asn Asp Ser Glu Lys Gln Arg Lys
  65                  70                  75                  80
 Ser Lys Val Glu Asp Lys Pro Phe Glu Glu Thr Gly Val Glu Pro Val
                  85                  90                  95    
 Leu Glu Thr Ala Ser Ser Ser Ala His Ser Thr Gln Lys Asp Ser Ser
             100                 105                 110        
 His Arg Ala Lys Leu Pro Leu Ala Lys Glu Lys Tyr Lys Ser Asp Lys
         115                 120                 125            
 Asp Ser Thr Ser Thr Arg Leu Glu Arg Lys Leu Ser Asp Gly His Lys
     130                 135                 140                
 Ser Arg Ser Leu Lys His Ser Ser Lys Asn Ile Lys Lys Lys Asp Glu
 145                 150                 155                 160
 Asn Lys Ser Asp Asp Lys Asp Gly Lys Glu Val Asp Ser Ser His Glu
                 165                 170                 175    
 Lys Ala Arg Gly Asn Ser Ser Leu Met Glu Lys Lys Leu Ser Arg Arg
             180                 185                 190        
 Leu Cys Glu Asn Arg Arg Gly Ser Leu Ser Gln Glu Met Ala Lys Gly
         195                 200                 205            
 Glu Glu Lys Leu Ala Ala Asn Thr Leu Ser Thr Pro Ser Gly Ser Ser
     210                 215                 220                
 Leu Gln Arg Pro Lys Lys Ser Gly Asp Met Thr Leu Ile Pro Glu Gln
 225                 230                 235                 240
 Glu Pro Met Glu Ile Asp Ser Glu Pro Gly Val Glu Asn Val Phe Glu
                 245                 250                 255    
 Val Ser Lys Thr Gln Asp Asn Arg Asn Asn Asn Ser Gln Gln Asp Ile
             260                 265                 270        
 Asp Ser Glu Asn Met Lys Gln Lys Thr Ser Ala Thr Val Gln Lys Asp
         275                 280                 285            
 Glu Leu Arg Thr Cys Thr Ala Asp Ser Lys Ala Thr Ala Pro Ala Tyr
     290                 295                 300                
 Lys Pro Gly Arg Gly Thr Gly Val Asn Ser Asn Ser Glu Lys His Ala
 305                 310                 315                 320
 Asp His Arg Ser Thr Leu Thr Lys Lys Met His Ile Gln Ser Ala Val
                 325                 330                 335    
 Ser Lys Met Asn Pro Gly Glu Lys Glu Pro Ile His Arg Gly Thr Thr
             340                 345                 350        
 Glu Val Asn Ile Asp Ser Glu Thr Val His Arg Met Leu Leu Ser Ala
         355                 360                 365            
 Pro Ser Glu Asn Asp Arg Val Gln Lys Asn Leu Lys Asn Thr Ala Ala
     370                 375                 380                
 Glu Glu His Val Ala Gln Gly Asp Ala Thr Leu Glu His Ser Thr Asn
 385                 390                 395                 400
 Leu Asp Ser Ser Pro Ser Leu Ser Ser Val Thr Val Val Pro Leu Arg
                 405                 410                 415    
 Glu Ser Tyr Asp Pro Asp Val Ile Pro Leu Phe Asp Lys Arg Thr Val
             420                 425                 430        
 Leu Glu Gly Ser Thr Ala Ser Thr Ser Pro Ala Asp His Ser Ala Leu
         435                 440                 445            
 Pro Asn Gln Ser Leu Thr Val Arg Glu Ser Glu Val Leu Lys Thr Ser
     450                 455                 460                
 Asp Ser Lys Glu Gly Gly Glu Gly Phe Thr Val Asp Thr Pro Ala Lys
 465                 470                 475                 480
 Ala Ser Ile Thr Ser Lys Arg His Ile Pro Glu Ala His Gln Ala Thr
                 485                 490                 495    
 Leu Leu Asp Gly Lys Gln Gly Lys Val Ile Met Pro Leu Gly Ser Lys
             500                 505                 510        
 Leu Thr Gly Val Ile Val Glu Asn Glu Asn Ile Thr Lys Glu Gly Gly
         515                 520                 525            
 Leu Val Asp Met Ala Lys Lys Glu Asn Asp Leu Asn Ala Glu Pro Asn
     530                 535                 540                
 Leu Lys Gln Thr Ile Lys Ala Thr Val Glu Asn Gly Lys Lys Asp Gly
 545                 550                 555                 560
 Ile Ala Val Asp His Val Val Gly Leu Asn Thr Glu Lys Tyr Ala Glu
                 565                 570                 575    
 Thr Val Lys Leu Lys His Lys Arg Ser Pro Gly Lys Val Lys Asp Ile
             580                 585                 590        
 Ser Ile Asp Val Glu Arg Arg Asn Glu Asn Ser Glu Val Asp Thr Ser
         595                 600                 605            
 Ala Gly Ser Gly Ser Ala Pro Ser Val Leu His Gln Arg Asn Gly Gln
     610                 615                 620                
 Thr Glu Asp Val Ala Thr Gly Pro Arg Arg Ala Glu Lys Thr Ser Val
 625                 630                 635                 640
 Ala Thr Ser Thr Glu Gly Lys Asp Lys Asp Val Thr Leu Ser Pro Val
                 645                 650                 655    
 Lys Ala Gly Pro Ala Thr Thr Thr Ser Ser Glu Thr Arg Gln Ser Glu
             660                 665                 670        
 Val Ala Leu Pro Cys Thr Ser Ile Glu Ala Asp Glu Gly Leu Ile Ile
         675                 680                 685            
 Gly Thr His Ser Arg Asn Asn Pro Leu His Val Gly Ala Glu Ala Ser
     690                 695                 700                
 Glu Cys Thr Val Phe Ala Ala Ala Glu Glu Gly Gly Ala Val Val Thr
 705                 710                 715                 720
 Glu Gly Phe Ala Glu Ser Glu Thr Phe Leu Thr Ser Thr Lys Glu Gly
                 725                 730                 735    
 Glu Ser Gly Glu Cys Ala Val Ala Glu Ser Glu Asp Arg Ala Ala Asp
             740                 745                 750        
 Leu Leu Ala Val His Ala Val Lys Ile Glu Ala Asn Val Asn Ser Val
         755                 760                 765            
 Val Thr Glu Glu Lys Asp Asp Ala Val Thr Ser Ala Gly Ser Glu Glu
     770                 775                 780                
 Lys Cys Asp Gly Ser Leu Ser Arg Asp Ser Glu Ile Val Glu Gly Thr
 785                 790                 795                 800
 Ile Thr Phe Ile Ser Glu Val Glu Ser Asp Gly Ala Val Thr Ser Ala
                 805                 810                 815    
 Gly Thr Glu Ile Arg Ala Gly Ser Ile Ser Ser Glu Glu Val Asp Gly
             820                 825                 830        
 Ser Gln Gly Asn Met Met Arg Met Gly Pro Lys Lys Glu Thr Glu Gly
         835                 840                 845            
 Thr Val Thr Cys Thr Gly Ala Glu Gly Arg Ser Asp Asn Phe Val Ile
     850                 855                 860                
 Cys Ser Val Thr Gly Ala Gly Pro Arg Glu Glu Arg Met Val Thr Gly
 865                 870                 875                 880
 Ala Gly Val Val Leu Gly Asp Asn Asp Ala Pro Pro Gly Thr Ser Ala
                 885                 890                 895    
 Ser Gln Glu Gly Asp Gly Ser Val Asn Asp Gly Thr Glu Gly Glu Ser
             900                 905                 910        
 Ala Val Thr Ser Thr Gly Ile Thr Glu Asp Gly Glu Gly Pro Ala Ser
         915                 920                 925            
 Cys Thr Gly Ser Glu Asp Ser Ser Glu Gly Phe Ala Ile Ser Ser Glu
     930                 935                 940                
 Ser Glu Glu Asn Gly Glu Ser Ala Met Asp Ser Thr Val Ala Lys Glu
 945                 950                 955                 960
 Gly Thr Asn Val Pro Leu Val Ala Ala Gly Pro Cys Asp Asp Glu Gly
                 965                 970                 975    
 Ile Val Thr Ser Thr Gly Ala Lys Glu Glu Asp Glu Glu Gly Glu Asp
             980                 985                 990        
 Val Val Thr Ser Thr Gly Arg Gly Asn Glu Ile Gly His Ala Ser Thr
         995                1000                1005            
 Cys Thr Gly Leu Gly Glu Glu Ser Glu Gly Val Leu Ile Cys Glu Ser
    1010                1015                1020                
 Ala Glu Gly Asp Ser Gln Ile Gly Thr Val Val Glu His Val Glu Ala
1025                1030                1035                1040
 Glu Ala Gly Ala Ala Ile Met Asn Ala Asn Glu Asn Asn Val Asp Ser
                1045                1050                1055    
 Met Ser Gly Thr Glu Lys Gly Ser Lys Asp Thr Asp Ile Cys Ser Ser
            1060                1065                1070        
 Ala Lys Gly Ile Val Glu Ser Ser Val Thr Ser Ala Val Ser Gly Lys
        1075                1080                1085            
 Asp Glu Val Thr Pro Val Pro Gly Gly Cys Glu Gly Pro Met Thr Ser
    1090                1095                1100                
 Ala Ala Ser Asp Gln Ser Asp Ser Gln Leu Glu Lys Val Glu Asp Thr
1105                1110                1115                1120
 Thr Ile Ser Thr Gly Leu Val Gly Gly Ser Tyr Asp Val Leu Val Ser
                1125                1130                1135    
 Gly Glu Val Pro Glu Cys Glu Val Ala His Thr Ser Pro Ser Glu Lys
            1140                1145                1150        
 Glu Asp Glu Asp Ile Ile Thr Ser Val Glu Asn Glu Glu Cys Asp Gly
        1155                1160                1165            
 Leu Met Ala Thr Thr Ala Ser Gly Asp Ile Thr Asn Gln Asn Ser Leu
    1170                1175                1180                
 Ala Gly Gly Lys Asn Gln Gly Lys Val Leu Ile Ile Ser Thr Ser Thr
1185                1190                1195                1200
 Thr Asn Asp Tyr Thr Pro Gln Val Ser Ala Ile Thr Asp Val Glu Gly
                1205                1210                1215    
 Gly Leu Ser Asp Ala Leu Arg Thr Glu Glu Asn Met Glu Gly Thr Arg
            1220                1225                1230        
 Val Thr Thr Glu Glu Phe Glu Ala Pro Met Pro Ser Ala Val Ser Gly
        1235                1240                1245            
 Asp Asp Ser Gln Leu Thr Ala Ser Arg Ser Glu Glu Lys Asp Glu Cys
    1250                1255                1260                
 Ala Met Ile Ser Thr Ser Ile Gly Glu Glu Phe Glu Leu Pro Ile Ser
1265                1270                1275                1280
 Ser Ala Thr Thr Ile Lys Cys Ala Glu Ser Leu Gln Pro Val Ala Ala
                1285                1290                1295    
 Ala Val Glu Glu Arg Ala Thr Gly Pro Val Leu Ile Ser Thr Ala Asp
            1300                1305                1310        
 Phe Glu Gly Pro Met Pro Ser Ala Pro Pro Glu Ala Glu Ser Pro Leu
        1315                1320                1325            
 Ala Ser Thr Ser Lys Glu Glu Lys Asp Glu Cys Ala Leu Ile Ser Thr
    1330                1335                1340                
 Ser Ile Ala Glu Glu Cys Glu Ala Ser Val Ser Gly Val Val Val Glu
1345                1350                1355                1360
 Ser Glu Asn Glu Arg Ala Gly Thr Val Met Glu Glu Lys Asp Gly Ser
                1365                1370                1375    
 Gly Ile Ile Ser Thr Ser Ser Val Glu Asp Cys Glu Gly Pro Val Ser
            1380                1385                1390        
 Ser Ala Val Pro Gln Glu Glu Gly Asp Pro Ser Val Thr Pro Ala Glu
        1395                1400                1405            
 Glu Met Gly Asp Thr Ala Met Ile Ser Thr Ser Thr Ser Glu Gly Cys
    1410                1415                1420                
 Glu Ala Val Met Ile Gly Ala Val Leu Gln Asp Glu Asp Arg Leu Thr
1425                1430                1435                1440
 Ile Thr Arg Val Glu Asp Leu Ser Asp Ala Ala Ile Ile Ser Thr Ser
                1445                1450                1455    
 Thr Ala Glu Cys Met Pro Ile Ser Ala Ser Ile Asp Arg His Glu Glu
            1460                1465                1470        
 Asn Gln Leu Thr Ala Asp Asn Pro Glu Gly Asn Gly Asp Leu Ser Ala
        1475                1480                1485            
 Thr Glu Val Ser Lys His Lys Val Pro Met Pro Ser Leu Ile Ala Glu
    1490                1495                1500                
 Asn Asn Cys Arg Cys Pro Gly Pro Val Arg Gly Gly Lys Glu Pro Gly
1505                1510                1515                1520
 Pro Val Leu Ala Val Ser Thr Glu Glu Gly His Asn Gly Pro Ser Val
                1525                1530                1535    
 His Lys Pro Ser Ala Gly Gln Gly His Pro Ser Ala Val Cys Ala Glu
            1540                1545                1550        
 Lys Glu Glu Lys His Gly Lys Glu Cys Pro Glu Ile Gly Pro Phe Ala
        1555                1560                1565            
 Gly Arg Gly Gln Lys Glu Ser Thr Leu His Leu Ile Asn Ala Glu Glu
    1570                1575                1580                
 Lys Asn Val Leu Leu Asn Ser Leu Gln Lys Glu Asp Lys Ser Pro Glu
1585                1590                1595                1600
 Thr Gly Thr Ala Gly Gly Ser Ser Thr Ala Ser Tyr Ser Ala Gly Arg
                1605                1610                1615    
 Gly Leu Glu Gly Asn Ala Asn Ser Pro Ala His Leu Arg Gly Pro Glu
            1620                1625                1630        
 Gln Thr Ser Gly Gln Thr Ala Lys Asp Ser Ser Val Ser Ser Ile Arg
        1635                1640                1645            
 Tyr Leu Ala Ala Val Asn Thr Gly Ala Ile Lys Ala Asp Asp Met Pro
    1650                1655                1660                
 Pro Val Gln Gly Thr Val Ala Glu His Ser Phe Leu Pro Ala Glu Gln
1665                1670                1675                1680
 Gln Gly Ser Glu Asp Asn Leu Lys Thr Ser Thr Thr Lys Cys Ile Thr
                1685                1690                1695    
 Gly Gln Glu Ser Lys Ile Ala Pro Ser His Thr Met Ile Pro Pro Ala
            1700                1705                1710        
 Thr Tyr Ser Val Ala Leu Leu Ala Pro Lys Cys Glu Gln Asp Leu Thr
        1715                1720                1725            
 Ile Lys Asn Asp Tyr Ser Gly Lys Trp Thr Asp Gln Ala Ser Ala Glu
    1730                1735                1740                
 Lys Thr Gly Asp Asp Asn Ser Thr Arg Lys Ser Phe Pro Glu Glu Gly
1745                1750                1755                1760
 Asp Ile Met Val Thr Val Ser Ser Glu Glu Asn Ala Tyr Val Pro Ser
                1765                1770                1775    
 Glu Glu Glu Lys Asn Gly Glu Ile Leu Ala Pro Pro Glu Ser Leu Cys
            1780                1785                1790        
 Gly Gly Lys Pro Ser Gly Ile Glu Ile Ser Ser Gly Arg Lys Asp Asn
        1795                1800                1805            
 Ala Glu Ala Ile Ser Gly His Ser Val Glu Ala Asp Pro Lys Glu Glu
    1810                1815                1820                
 Glu Asn Ser Arg Asp Leu Glu Glu Leu Pro Lys Thr Ser Ser Glu Thr
1825                1830                1835                1840
 Asn Ser Thr Thr Ser Arg Val Met Glu Glu Lys Asp Glu Tyr Ser Ser
                1845                1850                1855    
 Ser Glu Thr Thr Gly Glu Lys Pro Glu Gln Asn Asp Asp Asp Thr Ile
            1860                1865                1870        
 Lys Ser Gln Glu Asp Asp Gly Glu Glu Lys Ile Val Thr Ser Val Arg
        1875                1880                1885            
 Arg Arg Gly Arg Lys Pro Lys Arg Ser Leu Thr Val Ser Asp Asp Ala
    1890                1895                1900                
 Glu Ser Ser Glu Pro Glu Arg Lys Arg Gln Lys Ser Val Ser Asp Pro
1905                1910                1915                1920
 Val Glu Asp Lys Lys Glu Gln Glu Ser Asp Glu Glu Glu Glu Glu Glu
                1925                1930                1935    
 Glu Glu Asp Glu Pro Ser Gly Ala Thr Thr Arg Ser Thr Thr Arg Ser
            1940                1945                1950        
 Glu Ala Gln Arg Lys Gln His Ser Lys Pro Ser Ala Arg Ala Thr Ser
        1955                1960                1965            
 Lys Leu Gly Ser Pro Asp Thr Val Ser Pro Arg Asn Arg Gln Lys Leu
    1970                1975                1980                
 Ala Lys Glu Lys Leu Pro Thr Ser Glu Lys Val Ser Asn Ser Pro Pro
1985                1990                1995                2000
 Leu Gly Arg Ser Lys Thr Gln Leu Ser Pro Ser Ile Lys Arg Lys Arg
                2005                2010                2015    
 Glu Val Ser Pro Pro Gly Ala Arg Thr Arg Gly Gln Gln Arg Val Glu
            2020                2025                2030        
 Glu Ala Pro Val Lys Lys Ala Lys Arg
        2035                2040    



      <210> 339
      <211> 1994
      <212> PRT
      <213> Homo sapiens


      <400> 339
 Met Asp Ser Thr Asn Met Asp Ser Asn Leu Lys Pro Glu Glu Val Val
   1               5                  10                  15    
 His Lys Glu Lys Arg Arg Thr Lys Ser Leu Leu Glu Glu Lys Leu Val
              20                  25                  30        
 Leu Lys Ser Lys Ser Lys Thr Gln Gly Lys Gln Val Lys Val Val Glu
          35                  40                  45            
 Thr Glu Leu Gln Glu Gly Ala Thr Lys Gln Ala Thr Thr Pro Lys Pro
      50                  55                  60                
 Asp Lys Glu Lys Asn Thr Glu Glu Asn Asp Ser Glu Lys Gln Arg Lys
  65                  70                  75                  80
 Ser Lys Val Glu Asp Lys Pro Phe Glu Glu Thr Gly Val Glu Pro Val
                  85                  90                  95    
 Leu Glu Thr Ala Ser Ser Ser Ala His Ser Thr Gln Lys Asp Ser Ser
             100                 105                 110        
 His Arg Ala Lys Leu Pro Leu Ala Lys Glu Lys Tyr Lys Ser Asp Lys
         115                 120                 125            
 Asp Ser Thr Ser Thr Arg Leu Glu Arg Lys Leu Ser Asp Gly His Lys
     130                 135                 140                
 Ser Arg Ser Leu Lys His Ser Ser Lys Asn Ile Lys Lys Lys Asp Glu
 145                 150                 155                 160
 Asn Lys Ser Asp Asp Lys Asp Gly Lys Glu Val Asp Ser Ser His Glu
                 165                 170                 175    
 Lys Ala Arg Gly Asn Ser Ser Leu Met Glu Lys Lys Leu Ser Arg Arg
             180                 185                 190        
 Leu Cys Glu Asn Arg Arg Gly Ser Leu Ser Gln Glu Met Ala Lys Gly
         195                 200                 205            
 Glu Glu Lys Leu Ala Ala Asn Thr Leu Ser Thr Pro Ser Gly Ser Ser
     210                 215                 220                
 Leu Gln Arg Pro Lys Lys Ser Gly Asp Met Thr Leu Ile Pro Glu Gln
 225                 230                 235                 240
 Glu Pro Met Glu Ile Asp Ser Glu Pro Gly Val Glu Asn Val Phe Glu
                 245                 250                 255    
 Val Ser Lys Thr Gln Asp Asn Arg Asn Asn Asn Ser Gln Gln Asp Ile
             260                 265                 270        
 Asp Ser Glu Asn Met Lys Gln Lys Thr Ser Ala Thr Val Gln Lys Asp
         275                 280                 285            
 Glu Leu Arg Thr Cys Thr Ala Asp Ser Lys Ala Thr Ala Pro Ala Tyr
     290                 295                 300                
 Lys Pro Gly Arg Gly Thr Gly Val Asn Ser Asn Ser Glu Lys His Ala
 305                 310                 315                 320
 Asp His Arg Ser Thr Leu Thr Lys Lys Met His Ile Gln Ser Ala Val
                 325                 330                 335    
 Ser Lys Met Asn Pro Gly Glu Lys Glu Pro Ile His Arg Gly Thr Thr
             340                 345                 350        
 Glu Val Asn Ile Asp Ser Glu Thr Val His Arg Met Leu Leu Ser Ala
         355                 360                 365            
 Pro Ser Glu Asn Asp Arg Val Gln Lys Asn Leu Lys Asn Thr Ala Ala
     370                 375                 380                
 Glu Glu His Val Ala Gln Gly Asp Ala Thr Leu Glu His Ser Thr Asn
 385                 390                 395                 400
 Leu Asp Ser Ser Pro Ser Leu Ser Ser Val Thr Val Val Pro Leu Arg
                 405                 410                 415    
 Glu Ser Tyr Asp Pro Asp Val Ile Pro Leu Phe Asp Lys Arg Thr Val
             420                 425                 430        
 Leu Glu Gly Ser Thr Ala Ser Thr Ser Pro Ala Asp His Ser Ala Leu
         435                 440                 445            
 Pro Asn Gln Ser Leu Thr Val Arg Glu Ser Glu Val Leu Lys Thr Ser
     450                 455                 460                
 Asp Ser Lys Glu Gly Gly Glu Gly Phe Thr Val Asp Thr Pro Ala Lys
 465                 470                 475                 480
 Ala Ser Ile Thr Ser Lys Arg His Ile Pro Glu Ala His Gln Ala Thr
                 485                 490                 495    
 Leu Leu Asp Gly Lys Gln Gly Lys Val Ile Met Pro Leu Gly Ser Lys
             500                 505                 510        
 Leu Thr Gly Val Ile Val Glu Asn Glu Asn Ile Thr Lys Glu Gly Gly
         515                 520                 525            
 Leu Val Asp Met Ala Lys Lys Glu Asn Asp Leu Asn Ala Glu Pro Asn
     530                 535                 540                
 Leu Lys Gln Thr Ile Lys Ala Thr Val Glu Asn Gly Lys Lys Asp Gly
 545                 550                 555                 560
 Ile Ala Val Asp His Val Val Gly Leu Asn Thr Glu Lys Tyr Ala Glu
                 565                 570                 575    
 Thr Val Lys Leu Lys His Lys Arg Ser Pro Gly Lys Val Lys Asp Ile
             580                 585                 590        
 Ser Ile Asp Val Glu Arg Arg Asn Glu Asn Ser Glu Val Asp Thr Ser
         595                 600                 605            
 Ala Gly Ser Gly Ser Ala Pro Ser Val Leu His Gln Arg Asn Gly Gln
     610                 615                 620                
 Thr Glu Asp Val Ala Thr Gly Pro Arg Arg Ala Glu Lys Thr Ser Val
 625                 630                 635                 640
 Ala Thr Ser Thr Glu Gly Lys Asp Lys Asp Val Thr Leu Ser Pro Val
                 645                 650                 655    
 Lys Ala Gly Pro Ala Thr Thr Thr Ser Ser Glu Thr Arg Gln Ser Glu
             660                 665                 670        
 Val Ala Leu Pro Cys Thr Ser Ile Glu Ala Asp Glu Gly Leu Ile Ile
         675                 680                 685            
 Gly Thr His Ser Arg Asn Asn Pro Leu His Val Gly Ala Glu Ala Ser
     690                 695                 700                
 Glu Cys Thr Val Phe Ala Ala Ala Glu Glu Gly Gly Ala Val Val Thr
 705                 710                 715                 720
 Glu Gly Phe Ala Glu Ser Glu Thr Phe Leu Thr Ser Thr Lys Glu Gly
                 725                 730                 735    
 Glu Ser Gly Glu Cys Ala Val Ala Glu Ser Glu Asp Arg Ala Ala Asp
             740                 745                 750        
 Leu Leu Ala Val His Ala Val Lys Ile Glu Ala Asn Val Asn Ser Val
         755                 760                 765            
 Val Thr Glu Glu Lys Asp Asp Ala Val Thr Ser Ala Gly Ser Glu Glu
     770                 775                 780                
 Lys Cys Asp Gly Ser Leu Ser Arg Asp Ser Glu Ile Val Glu Gly Thr
 785                 790                 795                 800
 Ile Thr Phe Ile Ser Glu Val Glu Ser Asp Gly Ala Val Thr Ser Ala
                 805                 810                 815    
 Gly Thr Glu Ile Arg Ala Gly Ser Ile Ser Ser Glu Glu Val Asp Gly
             820                 825                 830        
 Ser Gln Gly Asn Met Met Arg Met Gly Pro Lys Lys Glu Thr Glu Gly
         835                 840                 845            
 Thr Val Thr Cys Thr Gly Ala Glu Gly Arg Ser Asp Asn Phe Val Ile
     850                 855                 860                
 Cys Ser Val Thr Gly Ala Gly Pro Arg Glu Glu Arg Met Val Thr Gly
 865                 870                 875                 880
 Ala Gly Val Val Leu Gly Asp Asn Asp Ala Pro Pro Gly Thr Ser Ala
                 885                 890                 895    
 Ser Gln Glu Gly Asp Gly Ser Val Asn Asp Gly Thr Glu Gly Glu Ser
             900                 905                 910        
 Ala Val Thr Ser Thr Gly Ile Thr Glu Asp Gly Glu Gly Pro Ala Ser
         915                 920                 925            
 Cys Thr Gly Ser Glu Asp Ser Ser Glu Gly Phe Ala Ile Ser Ser Glu
     930                 935                 940                
 Ser Glu Glu Asn Gly Glu Ser Ala Met Asp Ser Thr Val Ala Lys Glu
 945                 950                 955                 960
 Gly Thr Asn Val Pro Leu Val Ala Ala Gly Pro Cys Asp Asp Glu Gly
                 965                 970                 975    
 Ile Val Thr Ser Thr Gly Ala Lys Glu Glu Asp Glu Glu Gly Glu Asp
             980                 985                 990        
 Val Val Thr Ser Thr Gly Arg Gly Asn Glu Ile Gly His Ala Ser Thr
         995                1000                1005            
 Cys Thr Gly Leu Gly Glu Glu Ser Glu Gly Val Leu Ile Cys Glu Ser
    1010                1015                1020                
 Ala Glu Gly Asp Ser Gln Ile Gly Thr Val Val Glu His Val Glu Ala
1025                1030                1035                1040
 Glu Ala Gly Ala Ala Ile Met Asn Ala Asn Glu Asn Asn Val Asp Ser
                1045                1050                1055    
 Met Ser Gly Thr Glu Lys Gly Ser Lys Asp Thr Asp Ile Cys Ser Ser
            1060                1065                1070        
 Ala Lys Gly Ile Val Glu Ser Ser Val Thr Ser Ala Val Ser Gly Lys
        1075                1080                1085            
 Asp Glu Val Thr Pro Val Pro Gly Gly Cys Glu Gly Pro Met Thr Ser
    1090                1095                1100                
 Ala Ala Ser Asp Gln Ser Asp Ser Gln Leu Glu Lys Val Glu Asp Thr
1105                1110                1115                1120
 Thr Ile Ser Thr Gly Leu Val Gly Gly Ser Tyr Asp Val Leu Val Ser
                1125                1130                1135    
 Gly Glu Val Pro Glu Cys Glu Val Ala His Thr Ser Pro Ser Glu Lys
            1140                1145                1150        
 Glu Asp Glu Asp Ile Ile Thr Ser Val Glu Asn Glu Glu Cys Asp Gly
        1155                1160                1165            
 Leu Met Ala Thr Thr Ala Ser Gly Asp Ile Thr Asn Gln Asn Ser Leu
    1170                1175                1180                
 Ala Gly Gly Lys Asn Gln Gly Lys Val Leu Ile Ile Ser Thr Ser Thr
1185                1190                1195                1200
 Thr Asn Asp Tyr Thr Pro Gln Val Ser Ala Ile Thr Asp Val Glu Gly
                1205                1210                1215    
 Gly Leu Ser Asp Ala Leu Arg Thr Glu Glu Asn Met Glu Gly Thr Arg
            1220                1225                1230        
 Val Thr Thr Glu Glu Phe Glu Ala Pro Met Pro Ser Ala Val Ser Gly
        1235                1240                1245            
 Asp Asp Ser Gln Leu Thr Ala Ser Arg Ser Glu Glu Lys Asp Glu Cys
    1250                1255                1260                
 Ala Met Ile Ser Thr Ser Ile Gly Glu Glu Phe Glu Leu Pro Ile Ser
1265                1270                1275                1280
 Ser Ala Thr Thr Ile Lys Cys Ala Glu Ser Leu Gln Pro Val Ala Ala
                1285                1290                1295    
 Ala Val Glu Glu Arg Ala Thr Gly Pro Val Leu Ile Ser Thr Ala Asp
            1300                1305                1310        
 Phe Glu Gly Pro Met Pro Ser Ala Pro Pro Glu Ala Glu Ser Pro Leu
        1315                1320                1325            
 Ala Ser Thr Ser Lys Glu Glu Lys Asp Glu Cys Ala Leu Ile Ser Thr
    1330                1335                1340                
 Ser Ile Ala Glu Glu Cys Glu Ala Ser Val Ser Gly Val Val Val Glu
1345                1350                1355                1360
 Ser Glu Asn Glu Arg Ala Gly Thr Val Met Glu Glu Lys Asp Gly Ser
                1365                1370                1375    
 Gly Ile Ile Ser Thr Ser Ser Val Glu Asp Cys Glu Gly Pro Val Ser
            1380                1385                1390        
 Ser Ala Val Pro Gln Glu Glu Gly Asp Pro Ser Val Thr Pro Ala Glu
        1395                1400                1405            
 Glu Met Gly Asp Thr Ala Met Ile Ser Thr Ser Thr Ser Glu Gly Cys
    1410                1415                1420                
 Glu Ala Val Met Ile Gly Ala Val Leu Gln Asp Glu Asp Arg Leu Thr
1425                1430                1435                1440
 Ile Thr Arg Val Glu Asp Leu Ser Asp Ala Ala Ile Ile Ser Thr Ser
                1445                1450                1455    
 Thr Ala Glu Cys Met Pro Ile Ser Ala Ser Ile Asp Arg His Glu Glu
            1460                1465                1470        
 Asn Gln Leu Thr Ala Asp Asn Pro Glu Gly Asn Gly Asp Leu Ser Ala
        1475                1480                1485            
 Thr Glu Val Ser Lys His Lys Val Pro Met Pro Ser Leu Ile Ala Glu
    1490                1495                1500                
 Asn Asn Cys Arg Cys Pro Gly Pro Val Arg Gly Gly Lys Glu Pro Gly
1505                1510                1515                1520
 Pro Val Leu Ala Val Ser Thr Glu Glu Gly His Asn Gly Pro Ser Val
                1525                1530                1535    
 His Lys Pro Ser Ala Gly Gln Gly His Pro Ser Ala Val Cys Ala Glu
            1540                1545                1550        
 Lys Glu Glu Lys His Gly Lys Glu Cys Pro Glu Ile Gly Pro Phe Ala
        1555                1560                1565            
 Gly Arg Gly Gln Lys Glu Ser Thr Leu His Leu Ile Asn Ala Glu Glu
    1570                1575                1580                
 Lys Asn Val Leu Leu Asn Ser Leu Gln Lys Glu Asp Lys Ser Pro Glu
1585                1590                1595                1600
 Thr Gly Thr Ala Gly Gly Ser Ser Thr Ala Ser Tyr Ser Ala Gly Arg
                1605                1610                1615    
 Gly Leu Glu Gly Asn Ala Asn Ser Pro Ala His Leu Arg Gly Pro Glu
            1620                1625                1630        
 Gln Thr Ser Gly Gln Thr Ala Lys Asp Ser Ser Val Ser Ser Ile Arg
        1635                1640                1645            
 Tyr Leu Ala Ala Val Asn Thr Gly Ala Ile Lys Ala Asp Asp Met Pro
    1650                1655                1660                
 Pro Val Gln Gly Thr Val Ala Glu His Ser Phe Leu Pro Ala Glu Gln
1665                1670                1675                1680
 Gln Gly Ser Glu Asp Asn Leu Lys Thr Ser Thr Thr Lys Cys Ile Thr
                1685                1690                1695    
 Gly Gln Glu Ser Lys Ile Ala Pro Ser His Thr Met Ile Pro Pro Ala
            1700                1705                1710        
 Thr Tyr Ser Val Ala Leu Leu Ala Pro Lys Cys Glu Gln Asp Leu Thr
        1715                1720                1725            
 Ile Lys Asn Asp Tyr Ser Gly Lys Trp Thr Asp Gln Ala Ser Ala Glu
    1730                1735                1740                
 Lys Thr Gly Asp Asp Asn Ser Thr Arg Lys Ser Phe Pro Glu Glu Gly
1745                1750                1755                1760
 Asp Ile Met Val Thr Val Ser Ser Glu Glu Asn Ala Tyr Val Pro Ser
                1765                1770                1775    
 Glu Glu Glu Lys Asn Gly Glu Ile Leu Ala Pro Pro Glu Ser Leu Cys
            1780                1785                1790        
 Gly Gly Lys Pro Ser Gly Ile Glu Ile Ser Ser Gly Arg Lys Asp Asn
        1795                1800                1805            
 Ala Glu Ala Ile Ser Gly His Ser Val Glu Ala Asp Pro Lys Glu Glu
    1810                1815                1820                
 Glu Asn Ser Arg Asp Leu Glu Glu Leu Pro Lys Thr Ser Ser Glu Thr
1825                1830                1835                1840
 Asn Ser Thr Thr Ser Arg Val Met Glu Glu Lys Asp Glu Tyr Ser Ser
                1845                1850                1855    
 Ser Glu Thr Thr Gly Glu Lys Pro Glu Gln Asn Asp Asp Asp Thr Ile
            1860                1865                1870        
 Lys Ser Gln Glu Asp Asp Gly Glu Glu Lys Ile Val Thr Ser Val Arg
        1875                1880                1885            
 Arg Arg Gly Arg Lys Pro Lys Arg Ser Leu Thr Val Ser Asp Asp Ala
    1890                1895                1900                
 Glu Ser Ser Glu Pro Glu Arg Lys Arg Gln Lys Ser Val Ser Asp Pro
1905                1910                1915                1920
 Val Glu Asp Lys Lys Glu Gln Glu Ser Asp Glu Glu Glu Glu Glu Glu
                1925                1930                1935    
 Glu Glu Asp Glu Pro Ser Gly Ala Thr Thr Arg Ser Thr Thr Arg Ser
            1940                1945                1950        
 Glu Ala Gln Arg Ser Lys Thr Gln Leu Ser Pro Ser Ile Lys Arg Lys
        1955                1960                1965            
 Arg Glu Val Ser Pro Pro Gly Ala Arg Thr Arg Gly Gln Gln Arg Val
    1970                1975                1980                
 Glu Glu Ala Pro Val Lys Lys Ala Lys Arg
1985                1990                



      <210> 340
      <211> 462
      <212> PRT
      <213> Homo sapiens


      <400> 340
 Met Asn Glu Ser Lys Pro Gly Asp Ser Gln Asn Leu Ala Cys Val Phe
   1               5                  10                  15    
 Cys Arg Lys His Asp Asp Cys Pro Asn Lys Tyr Gly Glu Lys Lys Thr
              20                  25                  30        
 Lys Glu Lys Trp Asn Leu Thr Val His Tyr Tyr Cys Leu Leu Met Ser
          35                  40                  45            
 Ser Gly Ile Trp Gln Arg Gly Lys Glu Glu Glu Gly Val Tyr Gly Phe
      50                  55                  60                
 Leu Ile Glu Asp Ile Arg Lys Glu Val Asn Arg Ala Ser Lys Leu Val
  65                  70                  75                  80
 Gln Ala Ile Asn Ala Gly Val Phe Phe Phe Arg Cys Thr Ile Cys Asn
                  85                  90                  95    
 Asn Ser Asp Ile Phe Gln Lys Glu Met Leu Arg Met Gly Ile His Ile
             100                 105                 110        
 Pro Glu Lys Asp Ala Ser Trp Glu Leu Glu Glu Asn Ala Tyr Gln Glu
         115                 120                 125            
 Leu Leu Gln His Tyr Glu Arg Cys Asp Val Arg Arg Cys Arg Cys Lys
     130                 135                 140                
 Glu Gly Arg Asp Tyr Asn Ala Pro Asp Ser Lys Trp Glu Ile Lys Arg
 145                 150                 155                 160
 Cys Gln Cys Cys Gly Ser Ser Gly Thr His Leu Ala Cys Ser Ser Leu
                 165                 170                 175    
 Arg Ser Trp Glu Gln Asn Trp Glu Cys Leu Glu Cys Arg Gly Ile Ile
             180                 185                 190        
 Tyr Asn Ser Ala Leu Lys Glu Asn Leu Tyr Tyr Glu Ala Gly Lys Met
         195                 200                 205            
 Leu Ala Ile Ser Leu Val His Gly Gly Pro Ser Pro Gly Phe Phe Ser
     210                 215                 220                
 Lys Thr Leu Phe Asn Cys Leu Val Tyr Gly Pro Glu Asn Thr Gln Pro
 225                 230                 235                 240
 Ile Leu Asp Asp Val Ser Asp Phe Asp Val Ala Gln Ile Ile Ile Arg
                 245                 250                 255    
 Ile Asn Thr Ala Thr Thr Val Ala Asp Leu Lys Ser Ile Ile Asn Glu
             260                 265                 270        
 Cys Tyr Asn Tyr Leu Glu Leu Ile Gly Cys Leu Arg Leu Ile Thr Thr
         275                 280                 285            
 Leu Ser Asp Lys Tyr Met Leu Val Lys Asp Ile Leu Gly Tyr His Val
     290                 295                 300                
 Ile Gln Arg Val His Thr Pro Phe Glu Ser Phe Lys Gln Gly Leu Lys
 305                 310                 315                 320
 Thr Leu Gly Val Leu Glu Lys Ile Gln Ala Tyr Pro Glu Ala Phe Cys
                 325                 330                 335    
 Ser Ile Leu Cys His Lys Pro Glu Ser Leu Ser Ala Lys Ile Leu Ser
             340                 345                 350        
 Glu Leu Phe Thr Val His Thr Leu Pro Asp Val Lys Ala Leu Gly Phe
         355                 360                 365            
 Trp Asn Ser Tyr Leu Gln Ala Val Glu Asp Gly Lys Ser Thr Thr Thr
     370                 375                 380                
 Met Glu Asp Ile Leu Ile Phe Ala Thr Gly Cys Ser Ser Ile Pro Pro
 385                 390                 395                 400
 Ala Gly Phe Lys Pro Thr Pro Ser Ile Glu Cys Leu His Val Asp Phe
                 405                 410                 415    
 Pro Val Gly Asn Lys Cys Asn Asn Cys Leu Ala Ile Pro Ile Thr Asn
             420                 425                 430        
 Thr Tyr Lys Glu Phe Gln Glu Asn Met Asp Phe Thr Ile Arg Asn Thr
         435                 440                 445            
 Leu Arg Leu Glu Lys Glu Glu Ser Ser His Tyr Ile Gly His
     450                 455                 460        



      <210> 341
      <211> 571
      <212> PRT
      <213> Homo sapiens


      <400> 341
 Met Ala Glu Leu Val Gln Gly Gln Ser Ala Pro Val Gly Met Lys Ala
   1               5                  10                  15    
 Glu Gly Phe Val Asp Ala Leu His Arg Val Arg Gln Ile Ala Ala Lys
              20                  25                  30        
 Ile Asp Ser Ile Pro His Leu Asn Asn Ser Thr Pro Leu Val Asp Pro
          35                  40                  45            
 Ser Val Tyr Gly Tyr Gly Val Gln Lys Arg Pro Leu Asp Asp Gly Gly
      50                  55                  60                
 Asn Gln Leu Gly Ala Leu Val His Gln Arg Thr Val Ile Thr Glu Glu
  65                  70                  75                  80
 Phe Lys Val Pro Asp Lys Met Val Gly Phe Ile Ile Gly Arg Gly Gly
                  85                  90                  95    
 Glu Gln Ile Ser Arg Ile Gln Ala Glu Ser Gly Cys Lys Ile Gln Ile
             100                 105                 110        
 Ala Ser Glu Ser Ser Gly Ile Pro Glu Arg Pro Cys Val Leu Thr Gly
         115                 120                 125            
 Thr Pro Glu Ser Ile Glu Gln Ala Lys Arg Leu Leu Gly Gln Ile Val
     130                 135                 140                
 Asp Arg Cys Arg Asn Gly Pro Gly Phe His Asn Asp Ile Asp Ser Asn
 145                 150                 155                 160
 Ser Thr Ile Gln Glu Ile Leu Ile Pro Ala Ser Lys Val Gly Leu Val
                 165                 170                 175    
 Ile Gly Arg Gly Gly Glu Thr Ile Lys Gln Leu Gln Glu Arg Thr Gly
             180                 185                 190        
 Val Lys Met Val Met Ile Gln Asp Gly Pro Leu Pro Thr Gly Ala Asp
         195                 200                 205            
 Lys Pro Leu Arg Ile Thr Gly Asp Ala Phe Lys Val Gln Gln Ala Arg
     210                 215                 220                
 Glu Met Val Leu Glu Ile Ile Arg Glu Lys Asp Gln Ala Asp Phe Arg
 225                 230                 235                 240
 Gly Val Arg Gly Asp Phe Asn Ser Arg Met Gly Gly Gly Ser Ile Glu
                 245                 250                 255    
 Val Ser Val Pro Arg Phe Ala Val Gly Ile Val Ile Gly Arg Asn Gly
             260                 265                 270        
 Glu Met Ile Lys Lys Ile Gln Asn Asp Ala Gly Val Arg Ile Gln Phe
         275                 280                 285            
 Lys Pro Asp Asp Gly Ile Ser Pro Glu Arg Ala Ala Gln Val Met Gly
     290                 295                 300                
 Pro Pro Asp Arg Cys Gln His Ala Ala His Ile Ile Ser Glu Leu Ile
 305                 310                 315                 320
 Leu Thr Ala Gln Glu Arg Asp Gly Phe Gly Gly Leu Ala Ala Ala Arg
                 325                 330                 335    
 Gly Arg Gly Arg Gly Arg Gly Asp Trp Ser Val Gly Ala Pro Gly Gly
             340                 345                 350        
 Val Gln Glu Ile Thr Tyr Thr Val Pro Ala Asp Lys Cys Gly Leu Val
         355                 360                 365            
 Ile Gly Lys Gly Gly Glu Asn Ile Lys Ser Ile Asn Gln Gln Ser Gly
     370                 375                 380                
 Ala His Val Glu Leu Gln Arg Asn Pro Pro Pro Asn Ser Asp Pro Asn
 385                 390                 395                 400
 Leu Arg Arg Phe Thr Ile Arg Gly Val Pro Gln Gln Ile Glu Val Ala
                 405                 410                 415    
 Arg Gln Leu Ile Asp Glu Lys Val Gly Gly Thr Asn Leu Gly Ala Pro
             420                 425                 430        
 Gly Ala Phe Gly Gln Ser Pro Phe Ser Gln Pro Pro Ala Pro Pro His
         435                 440                 445            
 Gln Asn Thr Phe Pro Pro Arg Ser Ser Gly Cys Phe Pro Asn Met Ala
     450                 455                 460                
 Ala Lys Val Asn Gly Asn Pro His Ser Thr Pro Val Ser Gly Pro Pro
 465                 470                 475                 480
 Ala Phe Leu Thr Gln Gly Trp Gly Ser Thr Tyr Gln Ala Trp Gln Gln
                 485                 490                 495    
 Pro Thr Gln Gln Val Pro Ser Gln Gln Ser Gln Pro Gln Ser Ser Gln
             500                 505                 510        
 Pro Asn Tyr Ser Lys Ala Trp Glu Asp Tyr Tyr Lys Lys Gln Ser His
         515                 520                 525            
 Ala Ala Ser Ala Ala Pro Gln Ala Ser Ser Pro Pro Asp Tyr Thr Met
     530                 535                 540                
 Ala Trp Ala Glu Tyr Tyr Arg Gln Gln Val Ala Phe Tyr Gly Gln Thr
 545                 550                 555                 560
 Leu Gly Gln Ala Gln Ala His Ser Gln Glu Gln
                 565                 570    



      <210> 342
      <211> 916
      <212> PRT
      <213> Homo sapiens


      <400> 342
 Met Pro Pro Leu Lys Ser Pro Ala Ala Phe His Glu Gln Arg Arg Ser
   1               5                  10                  15    
 Leu Glu Arg Ala Arg Thr Glu Asp Tyr Leu Lys Arg Lys Ile Arg Ser
              20                  25                  30        
 Arg Pro Glu Arg Ser Glu Leu Val Arg Met His Ile Leu Glu Glu Thr
          35                  40                  45            
 Ser Ala Glu Pro Ser Leu Gln Ala Lys Gln Leu Lys Leu Lys Arg Ala
      50                  55                  60                
 Arg Leu Ala Asp Asp Leu Asn Glu Lys Ile Ala Gln Arg Pro Gly Pro
  65                  70                  75                  80
 Met Glu Leu Val Glu Lys Asn Ile Leu Pro Val Glu Ser Ser Leu Lys
                  85                  90                  95    
 Glu Ala Ile Ile Val Gly Gln Val Asn Tyr Pro Lys Val Ala Asp Ser
             100                 105                 110        
 Ser Ser Phe Asp Glu Asp Ser Ser Asp Ala Leu Ser Pro Glu Gln Pro
         115                 120                 125            
 Ala Ser His Glu Ser Gln Gly Ser Val Pro Ser Pro Leu Glu Ala Arg
     130                 135                 140                
 Val Ser Glu Pro Leu Leu Ser Ala Thr Ser Ala Ser Pro Thr Gln Val
 145                 150                 155                 160
 Val Ser Gln Leu Pro Met Gly Arg Asp Ser Arg Glu Met Leu Phe Leu
                 165                 170                 175    
 Ala Glu Gln Pro Pro Leu Pro Pro Pro Pro Leu Leu Pro Pro Ser Leu
             180                 185                 190        
 Thr Asn Gly Thr Thr Ile Pro Thr Ala Lys Ser Thr Pro Thr Leu Ile
         195                 200                 205            
 Lys Gln Ser Gln Pro Lys Ser Ala Ser Glu Lys Ser Gln Arg Ser Lys
     210                 215                 220                
 Lys Ala Lys Glu Leu Lys Pro Lys Val Lys Lys Leu Lys Tyr His Gln
 225                 230                 235                 240
 Tyr Ile Pro Pro Asp Gln Lys Gln Asp Arg Gly Ala Pro Pro Met Asp
                 245                 250                 255    
 Ser Ser Tyr Ala Lys Ile Leu Gln Gln Gln Gln Leu Phe Leu Gln Leu
             260                 265                 270        
 Gln Ile Leu Asn Gln Gln Gln Gln Gln His His Asn Tyr Gln Ala Ile
         275                 280                 285            
 Leu Pro Ala Pro Pro Lys Ser Ala Gly Glu Ala Leu Gly Ser Ser Gly
     290                 295                 300                
 Thr Pro Pro Val Arg Ser Leu Ser Thr Thr Asn Ser Ser Ser Ser Ser
 305                 310                 315                 320
 Gly Ala Pro Gly Pro Cys Gly Leu Ala Arg Gln Asn Ser Thr Ser Leu
                 325                 330                 335    
 Thr Gly Lys Pro Gly Ala Leu Pro Ala Asn Leu Asp Asp Met Lys Val
             340                 345                 350        
 Ala Glu Leu Lys Gln Glu Leu Lys Leu Arg Ser Leu Pro Val Ser Gly
         355                 360                 365            
 Thr Lys Thr Glu Leu Ile Glu Arg Leu Arg Ala Tyr Gln Asp Gln Ile
     370                 375                 380                
 Ser Pro Val Pro Gly Ala Pro Lys Ala Pro Ala Ala Thr Ser Ile Leu
 385                 390                 395                 400
 His Lys Ala Gly Glu Val Val Val Ala Phe Pro Ala Ala Arg Leu Ser
                 405                 410                 415    
 Thr Gly Pro Ala Leu Val Ala Ala Gly Leu Ala Pro Ala Glu Val Val
             420                 425                 430        
 Val Ala Thr Val Ala Ser Ser Gly Val Val Lys Phe Gly Ser Thr Gly
         435                 440                 445            
 Ser Thr Pro Pro Val Ser Pro Thr Pro Ser Glu Arg Ser Leu Leu Ser
     450                 455                 460                
 Thr Gly Asp Glu Asn Ser Thr Pro Gly Asp Thr Phe Gly Glu Met Val
 465                 470                 475                 480
 Thr Ser Pro Leu Thr Gln Leu Thr Leu Gln Ala Ser Pro Leu Gln Ile
                 485                 490                 495    
 Leu Val Lys Glu Glu Gly Pro Arg Ala Gly Ser Cys Cys Leu Ser Pro
             500                 505                 510        
 Gly Gly Arg Ala Glu Leu Glu Gly Arg Asp Lys Asp Gln Met Leu Gln
         515                 520                 525            
 Glu Lys Asp Lys Gln Ile Glu Ala Leu Thr Arg Met Leu Arg Gln Lys
     530                 535                 540                
 Gln Gln Leu Val Glu Arg Leu Lys Leu Gln Leu Glu Gln Glu Lys Arg
 545                 550                 555                 560
 Ala Gln Gln Pro Ala Pro Ala Pro Ala Pro Leu Gly Thr Pro Val Lys
                 565                 570                 575    
 Gln Glu Asn Ser Phe Ser Ser Cys Gln Leu Ser Gln Gln Pro Leu Gly
             580                 585                 590        
 Pro Ala His Pro Phe Asn Pro Ser Leu Ala Ala Pro Ala Thr Asn His
         595                 600                 605            
 Ile Asp Pro Cys Ala Val Ala Pro Gly Pro Pro Ser Val Val Val Lys
     610                 615                 620                
 Gln Glu Ala Leu Gln Pro Glu Pro Glu Pro Val Pro Ala Pro Gln Leu
 625                 630                 635                 640
 Leu Leu Gly Pro Gln Gly Pro Ser Leu Ile Lys Gly Val Ala Pro Pro
                 645                 650                 655    
 Thr Leu Ile Thr Asp Ser Thr Gly Thr His Leu Val Leu Thr Val Thr
             660                 665                 670        
 Asn Lys Asn Ala Asp Ser Pro Gly Leu Ser Ser Gly Ser Pro Gln Glu
         675                 680                 685            
 Met Asp Leu Glu His Pro Leu Gln Pro Leu Phe Gly Thr Pro Thr Ser
     690                 695                 700                
 Leu Leu Lys Lys Glu Pro Pro Gly Tyr Glu Glu Ala Met Ser Gln Gln
 705                 710                 715                 720
 Pro Lys Gln Gln Glu Asn Gly Ser Ser Ser Gln Gln Met Asp Asp Leu
                 725                 730                 735    
 Phe Asp Ile Leu Ile Gln Ser Gly Glu Ile Ser Ala Asp Phe Lys Glu
             740                 745                 750        
 Pro Pro Ser Leu Pro Gly Lys Glu Lys Pro Ser Pro Lys Thr Val Cys
         755                 760                 765            
 Gly Ser Pro Leu Ala Ala Gln Pro Ser Pro Ser Ala Glu Leu Pro Gln
     770                 775                 780                
 Ala Ala Pro Pro Pro Pro Gly Ser Pro Ser Leu Pro Gly Arg Leu Glu
 785                 790                 795                 800
 Asp Phe Leu Glu Ser Ser Thr Gly Leu Pro Leu Leu Thr Ser Gly His
                 805                 810                 815    
 Asp Gly Pro Glu Pro Leu Ser Leu Ile Asp Asp Leu His Ser Gln Met
             820                 825                 830        
 Leu Ser Ser Thr Ala Ile Leu Asp His Pro Pro Ser Pro Met Asp Thr
         835                 840                 845            
 Ser Glu Leu His Phe Val Pro Glu Pro Ser Ser Thr Met Gly Leu Asp
     850                 855                 860                
 Leu Ala Asp Gly His Leu Asp Ser Met Asp Trp Leu Glu Leu Ser Ser
 865                 870                 875                 880
 Gly Gly Pro Val Leu Ser Leu Ala Pro Leu Ser Thr Thr Ala Pro Ser
                 885                 890                 895    
 Leu Phe Ser Thr Asp Phe Leu Asp Gly His Asp Leu Gln Leu His Trp
             900                 905                 910        
 Asp Ser Cys Leu
         915    



      <210> 343
      <211> 77
      <212> PRT
      <213> Homo sapiens


      <400> 343
 Met Gly Asp Val Lys Asn Phe Leu Tyr Ala Trp Cys Gly Lys Arg Lys
   1               5                  10                  15    
 Met Thr Pro Ser Tyr Glu Ile Arg Ala Val Gly Asn Lys Asn Arg Gln
              20                  25                  30        
 Lys Phe Met Cys Glu Val Gln Val Glu Gly Tyr Asn Tyr Thr Gly Met
          35                  40                  45            
 Gly Asn Ser Thr Asn Lys Lys Asp Ala Gln Ser Asn Ala Ala Arg Asp
      50                  55                  60                
 Phe Val Asn Tyr Ser Gly Arg Ile Asn Glu Ile Asp Met
  65                  70                  75        



      <210> 344
      <211> 252
      <212> PRT
      <213> Homo sapiens


      <400> 344
 Met Gly Asn Ala Glu Val Gly Lys Ser Cys Ile Ile Lys Arg Tyr Cys
   1               5                  10                  15    
 Glu Lys Arg Phe Val Ser Lys Tyr Leu Ala Thr Ile Gly Ile Asp Tyr
              20                  25                  30        
 Gly Val Thr Lys Val His Val Arg Asp Arg Glu Ile Lys Val Asn Ile
          35                  40                  45            
 Phe Asp Met Ala Gly His Pro Phe Phe Tyr Glu Val Arg Asn Glu Phe
      50                  55                  60                
 Tyr Lys Asp Thr Gln Gly Val Ile Leu Val Tyr Asp Val Gly Gln Lys
  65                  70                  75                  80
 Asp Ser Phe Asp Ala Leu Asp Ala Trp Leu Ala Glu Met Lys Gln Glu
                  85                  90                  95    
 Leu Gly Pro His Gly Asn Met Glu Asn Ile Ile Phe Val Val Cys Ala
             100                 105                 110        
 Asn Lys Ile Asp Cys Thr Lys His Arg Cys Val Asp Glu Ser Glu Gly
         115                 120                 125            
 Arg Leu Trp Ala Glu Ser Lys Gly Phe Leu Tyr Phe Glu Thr Ser Ala
     130                 135                 140                
 Gln Thr Gly Glu Gly Ile Asn Glu Met Phe Gln Thr Phe Tyr Ile Ser
 145                 150                 155                 160
 Ile Val Asp Leu Cys Glu Asn Gly Gly Lys Arg Pro Thr Thr Asn Ser
                 165                 170                 175    
 Ser Ala Ser Phe Thr Lys Glu Gln Ala Asp Ala Ile Arg Arg Ile Arg
             180                 185                 190        
 Asn Ser Lys Asp Ser Trp Asp Met Leu Gly Val Lys Pro Gly Ala Ser
         195                 200                 205            
 Arg Asp Glu Val Asn Lys Ala Tyr Arg Lys Leu Ala Val Leu Leu His
     210                 215                 220                
 Pro Asp Lys Cys Val Ala Pro Gly Ser Glu Asp Ala Phe Lys Ala Val
 225                 230                 235                 240
 Val Asn Ala Arg Thr Ala Leu Leu Lys Asn Ile Lys
                 245                 250        



      <210> 345
      <211> 63
      <212> PRT
      <213> Homo sapiens


      <400> 345
 Met Glu Ser His Ser Arg Lys Ser Leu Phe Pro Glu Ser Ala Ile Val
   1               5                  10                  15    
 Ala Arg Gly His Val Phe Gln Gln Arg Leu Gly Ser Gly Pro Leu Cys
              20                  25                  30        
 Pro Leu Pro Thr Leu Ser Pro Lys Ser Gly Pro Pro Leu Thr Ser Leu
          35                  40                  45            
 Ala Leu His Leu Gly Val Pro Pro Ser Pro Arg Tyr Gly Pro Arg
      50                  55                  60            



      <210> 346
      <211> 1594
      <212> PRT
      <213> Homo sapiens


      <400> 346
 Met Gly Phe His His Val Gly His Ala Gly Leu Glu His Leu Thr Ser
   1               5                  10                  15    
 Gly Asp Arg Leu Gly Arg Arg Ser Ser Ser Lys Arg Ala Leu Lys Ala
              20                  25                  30        
 Glu Gly Thr Pro Gly Arg Arg Gly Ala Gln Arg Ser Gln Lys Glu Arg
          35                  40                  45            
 Ala Gly Gly Ser Pro Ser Pro Gly Ser Pro Arg Arg Lys Gln Thr Gly
      50                  55                  60                
 Arg Arg Arg His Arg Glu Glu Leu Gly Glu Gln Glu Arg Gly Glu Ala
  65                  70                  75                  80
 Glu Arg Thr Cys Glu Gly Arg Arg Lys Arg Asp Glu Arg Ala Ser Phe
                  85                  90                  95    
 Gln Glu Arg Thr Ala Ala Pro Lys Arg Glu Lys Glu Ile Pro Arg Arg
             100                 105                 110        
 Glu Glu Lys Ser Lys Arg Gln Lys Lys Pro Arg Ser Ser Ser Leu Ala
         115                 120                 125            
 Ser Ser Ala Ser Gly Gly Glu Ser Leu Ser Glu Glu Glu Leu Ala Arg
     130                 135                 140                
 Ile Leu Glu Gln Val Glu Glu Lys Lys Lys Leu Ile Ala Thr Met Arg
 145                 150                 155                 160
 Ser Lys Pro Trp Pro Met Ala Lys Lys Leu Thr Glu Leu Arg Glu Ala
                 165                 170                 175    
 Gln Glu Phe Val Glu Lys Tyr Glu Gly Ala Leu Gly Lys Gly Lys Gly
             180                 185                 190        
 Lys Gln Leu Tyr Ala Tyr Lys Met Leu Met Ala Lys Lys Trp Val Lys
         195                 200                 205            
 Phe Lys Arg Asp Phe Asp Asn Phe Lys Thr Gln Cys Ile Pro Trp Glu
     210                 215                 220                
 Met Lys Ile Lys Asp Ile Glu Ser His Phe Gly Ser Ser Val Ala Ser
 225                 230                 235                 240
 Tyr Phe Ile Phe Leu Arg Trp Met Tyr Gly Val Asn Leu Val Leu Phe
                 245                 250                 255    
 Gly Leu Ile Phe Gly Leu Val Ile Ile Pro Glu Asp Val Tyr Val Ile
             260                 265                 270        
 Pro Glu Glu Pro Ser Val Met Leu Gln Glu Leu Ala Gly Lys Ala Pro
         275                 280                 285            
 Leu Asp Asp Lys Phe Met Tyr Phe Ser Ser Asn Thr Gly Ser Tyr Gly
     290                 295                 300                
 Leu Gly Phe Asp Gln Gly Tyr Asn Tyr Leu Glu Ala Glu Leu Lys Lys
 305                 310                 315                 320
 Ile Arg Phe Gln Ala His Ser His Gly Tyr Trp Gln Ile Ser Glu Asp
                 325                 330                 335    
 Thr Ile Ser Ser Leu Leu Thr Trp Leu Leu Ala Gly Leu Arg Lys Ser
             340                 345                 350        
 Ala Ser Asn Leu Thr Tyr Val Ala Val Pro Lys Val Gln Gly Tyr Ile
         355                 360                 365            
 Lys Tyr Ser Ala Leu Phe Tyr Gly Tyr Tyr Asn Asn Gln Arg Thr Ile
     370                 375                 380                
 Gly Trp Leu Arg Tyr Arg Leu Pro Met Ala Tyr Phe Met Val Gly Val
 385                 390                 395                 400
 Ser Val Phe Gly Tyr Ser Leu Ile Ile Val Ile Arg Ser Met Ala Ser
                 405                 410                 415    
 Asn Thr Gln Gly Ser Thr Gly Glu Gly Glu Ser Asp Asn Phe Thr Phe
             420                 425                 430        
 Ser Phe Lys Met Phe Thr Ser Trp Asp Tyr Leu Ile Gly Asn Ser Glu
         435                 440                 445            
 Thr Ala Asp Asn Lys Tyr Ala Ser Ile Thr Thr Ser Phe Lys Glu Ser
     450                 455                 460                
 Ile Val Asp Glu Gln Glu Ser Asn Lys Glu Glu Asn Ile His Leu Thr
 465                 470                 475                 480
 Arg Phe Leu Arg Val Leu Ala Asn Phe Leu Ile Ile Cys Cys Leu Cys
                 485                 490                 495    
 Gly Ser Gly Tyr Leu Ile Tyr Phe Val Val Lys Arg Ser Gln Gln Phe
             500                 505                 510        
 Ser Lys Met Gln Asn Val Ser Trp Tyr Glu Arg Asn Glu Val Glu Ile
         515                 520                 525            
 Val Met Ser Leu Leu Gly Met Phe Cys Pro Pro Leu Phe Glu Thr Ile
     530                 535                 540                
 Ala Ala Leu Glu Asn Tyr His Pro Arg Thr Gly Leu Lys Trp Gln Leu
 545                 550                 555                 560
 Gly Arg Ile Phe Ala Leu Phe Leu Gly Asn Leu Tyr Thr Phe Leu Leu
                 565                 570                 575    
 Ala Leu Met Asp Asp Val His Leu Lys Leu Ala Asn Glu Glu Thr Ile
             580                 585                 590        
 Lys Asn Ile Thr His Trp Thr Leu Phe Asn Tyr Tyr Asn Ser Ser Gly
         595                 600                 605            
 Trp Asn Glu Ser Val Pro Arg Pro Pro Leu His Pro Ala Asp Val Pro
     610                 615                 620                
 Arg Gly Ser Cys Trp Glu Thr Ala Val Gly Ile Glu Phe Met Arg Leu
 625                 630                 635                 640
 Thr Val Ser Asp Met Leu Val Thr Tyr Ile Thr Ile Leu Leu Gly Asp
                 645                 650                 655    
 Phe Leu Arg Ala Cys Phe Val Arg Phe Met Asn Tyr Cys Trp Cys Trp
             660                 665                 670        
 Asp Leu Glu Ala Gly Phe Pro Ser Tyr Ala Glu Phe Asp Ile Ser Gly
         675                 680                 685            
 Asn Val Leu Gly Leu Ile Phe Asn Gln Gly Met Ile Trp Met Gly Ser
     690                 695                 700                
 Phe Tyr Ala Pro Gly Leu Val Gly Ile Asn Val Leu Arg Leu Leu Thr
 705                 710                 715                 720
 Ser Met Tyr Phe Gln Cys Trp Ala Val Met Ser Ser Asn Val Pro His
                 725                 730                 735    
 Glu Arg Val Phe Lys Ala Ser Arg Ser Asn Asn Phe Tyr Met Gly Leu
             740                 745                 750        
 Leu Leu Leu Val Leu Phe Leu Ser Leu Leu Pro Val Ala Tyr Thr Ile
         755                 760                 765            
 Met Ser Leu Pro Pro Ser Phe Asp Cys Gly Pro Phe Ser Gly Lys Asn
     770                 775                 780                
 Arg Met Tyr Asp Val Leu Gln Glu Thr Ile Glu Asn Asp Phe Pro Thr
 785                 790                 795                 800
 Phe Leu Gly Lys Ile Phe Ala Phe Leu Ala Asn Pro Gly Leu Ile Ile
                 805                 810                 815    
 Pro Ala Ile Leu Leu Met Phe Leu Ala Ile Tyr Tyr Leu Asn Ser Val
             820                 825                 830        
 Ser Lys Ser Leu Ser Arg Ala Asn Ala Gln Leu Arg Lys Lys Ile Gln
         835                 840                 845            
 Val Leu Arg Glu Val Glu Lys Ser His Lys Ser Val Lys Gly Lys Ala
     850                 855                 860                
 Thr Ala Arg Asp Ser Glu Asp Thr Pro Lys Ser Ser Ser Lys Asn Ala
 865                 870                 875                 880
 Thr Gln Leu Gln Leu Thr Lys Glu Glu Thr Thr Pro Pro Ser Ala Ser
                 885                 890                 895    
 Gln Ser Gln Ala Met Asp Lys Lys Ala Gln Gly Pro Gly Thr Ser Asn
             900                 905                 910        
 Ser Ala Ser Arg Thr Thr Leu Pro Ala Ser Gly His Leu Pro Ile Ser
         915                 920                 925            
 Arg Pro Pro Gly Ile Gly Pro Asp Ser Gly His Ala Pro Ser Gln Thr
     930                 935                 940                
 His Pro Trp Arg Gln Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Gly
 945                 950                 955                 960
 Leu Gly Leu Arg Leu Arg Leu Pro Trp Glu Arg Val Pro Ala Asp Ala
                 965                 970                 975    
 Glu Val Ala Leu Thr Leu Ala Pro Arg Leu Pro Phe Gln Val Leu Leu
             980                 985                 990        
 His Val Leu Phe Glu His Ala Val Gly Tyr Ala Leu Leu Ala Leu Lys
         995                1000                1005            
 Glu Val Glu Glu Ile Ser Leu Leu Gln Pro Ala Ala Cys Thr Ala Arg
    1010                1015                1020                
 Ser His Val Ala Gly Arg Pro Val Glu Glu Ser Val Leu Asn Leu Gly
1025                1030                1035                1040
 Lys Phe His Ser Ile Val Arg Leu Val Ala Phe Cys Pro Phe Ala Ser
                1045                1050                1055    
 Ser Gln Val Ala Leu Glu Asn Ala Asn Ala Val Ser Glu Gly Val Val
            1060                1065                1070        
 His Glu Asp Leu Arg Leu Leu Leu Glu Thr His Leu Pro Ser Lys Lys
        1075                1080                1085            
 Lys Lys Val Leu Leu Gly Val Gly Asp Pro Lys Ile Gly Ala Ala Ile
    1090                1095                1100                
 Gln Glu Glu Leu Gly Tyr Asn Cys Gln Thr Gly Gly Val Ile Ala Glu
1105                1110                1115                1120
 Ile Leu Arg Gly Val Arg Leu His Phe His Asn Leu Val Lys Gly Leu
                1125                1130                1135    
 Thr Asp Leu Ser Ala Cys Lys Ala Gln Leu Gly Leu Gly His Ser Tyr
            1140                1145                1150        
 Ser Arg Ala Lys Val Lys Phe Asn Val Asn Arg Val Asp Asn Met Ile
        1155                1160                1165            
 Ile Gln Ser Ile Ser Leu Leu Asp Gln Leu Asp Lys Asp Ile Asn Thr
    1170                1175                1180                
 Phe Ser Met Arg Val Arg Glu Trp Tyr Gly Tyr His Phe Pro Glu Leu
1185                1190                1195                1200
 Val Lys Ile Ile Asn Asp Asn Ala Thr Tyr Cys Arg Leu Ala Gln Phe
                1205                1210                1215    
 Ile Gly Asn Arg Arg Glu Leu Asn Glu Asp Lys Leu Glu Lys Leu Glu
            1220                1225                1230        
 Glu Leu Thr Met Asp Gly Ala Lys Ala Lys Ala Ile Leu Asp Ala Ser
        1235                1240                1245            
 Arg Ser Ser Met Gly Met Asp Ile Ser Ala Ile Asp Leu Ile Asn Ile
    1250                1255                1260                
 Glu Ser Phe Ser Ser Arg Val Val Ser Leu Ser Glu Tyr Arg Gln Ser
1265                1270                1275                1280
 Leu His Thr Tyr Leu Arg Ser Lys Met Ser Gln Val Ala Pro Ser Leu
                1285                1290                1295    
 Ser Ala Leu Ile Gly Glu Ala Val Gly Ala Arg Leu Ile Ala His Ala
            1300                1305                1310        
 Gly Ser Leu Thr Asn Leu Ala Lys Tyr Pro Ala Ser Thr Val Gln Ile
        1315                1320                1325            
 Leu Gly Ala Glu Lys Ala Leu Phe Arg Ala Leu Lys Thr Arg Gly Asn
    1330                1335                1340                
 Thr Pro Lys Tyr Gly Leu Ile Phe His Ser Thr Phe Ile Gly Arg Ala
1345                1350                1355                1360
 Ala Ala Lys Asn Lys Gly Arg Ile Ser Arg Tyr Leu Ala Asn Lys Cys
                1365                1370                1375    
 Ser Ile Ala Ser Arg Ile Asp Cys Phe Ser Glu Val Pro Thr Ser Val
            1380                1385                1390        
 Phe Gly Glu Lys Leu Arg Glu Gln Val Glu Glu Arg Leu Ser Phe Tyr
        1395                1400                1405            
 Glu Thr Gly Glu Ile Pro Arg Lys Asn Leu Asp Val Met Lys Glu Ala
    1410                1415                1420                
 Met Val Gln Ala Glu Glu Ala Ala Ala Glu Ile Thr Arg Lys Leu Glu
1425                1430                1435                1440
 Lys Gln Glu Lys Lys Arg Leu Lys Lys Glu Lys Lys Arg Leu Ala Ala
                1445                1450                1455    
 Leu Ala Leu Ala Ser Ser Glu Asn Ser Ser Ser Thr Pro Glu Glu Cys
            1460                1465                1470        
 Glu Glu Met Ser Glu Lys Pro Lys Lys Lys Lys Lys Gln Lys Pro Gln
        1475                1480                1485            
 Glu Val Pro Gln Glu Asn Gly Met Glu Asp Pro Ser Ile Ser Phe Ser
    1490                1495                1500                
 Lys Pro Lys Lys Lys Lys Ser Phe Ser Lys Glu Glu Leu Met Ser Ser
1505                1510                1515                1520
 Asp Leu Glu Glu Thr Ala Gly Ser Thr Ser Ile Pro Lys Arg Lys Lys
                1525                1530                1535    
 Ser Thr Pro Lys Glu Glu Thr Val Asn Asp Pro Glu Glu Ala Gly His
            1540                1545                1550        
 Arg Ser Gly Ser Lys Lys Lys Arg Lys Phe Ser Lys Glu Glu Pro Val
        1555                1560                1565            
 Ser Ser Gly Pro Glu Glu Ala Ala Gly Lys Ser Ser Ser Lys Lys Lys
    1570                1575                1580                
 Lys Lys Phe His Lys Ala Ser Gln Glu Asp
1585                1590                



      <210> 347
      <211> 427
      <212> PRT
      <213> Homo sapiens


      <400> 347
 Met Thr Thr Ala Ala Ser Glu Val Pro Ser Phe Leu Val Glu Arg Met
   1               5                  10                  15    
 Ala Asn Val Arg Arg Arg Arg Gln Asp Arg Arg Gly Met Glu Gly Gly
              20                  25                  30        
 Ile Leu Lys Ser Arg Ile Val Thr Trp Glu Pro Ser Glu Glu Phe Val
          35                  40                  45            
 Arg Asn Asn His Val Ile Asn Thr Pro Leu Gln Thr Met His Ile Met
      50                  55                  60                
 Ala Asp Leu Gly Pro Tyr Lys Lys Leu Gly Tyr Lys Lys Tyr Glu His
  65                  70                  75                  80
 Val Leu Cys Thr Leu Lys Val Asp Ser Asn Gly Val Ile Thr Val Lys
                  85                  90                  95    
 Pro Asp Phe Thr Gly Leu Lys Gly Pro Tyr Arg Ile Glu Thr Glu Gly
             100                 105                 110        
 Glu Lys Gln Glu Leu Trp Lys Tyr Thr Ile Asp Asn Val Ser Pro His
         115                 120                 125            
 Ala Gln Pro Glu Glu Glu Glu Arg Glu Arg Arg Val Phe Lys Asp Leu
     130                 135                 140                
 Tyr Gly Arg His Lys Glu Tyr Leu Ser Ser Leu Val Gly Thr Asp Phe
 145                 150                 155                 160
 Glu Met Thr Val Pro Gly Ala Leu Arg Leu Phe Val Asn Gly Glu Val
                 165                 170                 175    
 Val Ser Ala Gln Gly Tyr Glu Tyr Asp Asn Leu Tyr Val His Phe Phe
             180                 185                 190        
 Val Glu Leu Pro Thr Ala Arg Glu Leu Thr Ile Phe Gly Leu Trp Leu
         195                 200                 205            
 Ser Asp Trp Ser Ser Pro Ala Phe Gln Gln Leu Ser Gly Val Thr Gln
     210                 215                 220                
 Thr Cys Thr Thr Lys Ser Leu Ala Met Asp Lys Val Ala His Phe Ser
 225                 230                 235                 240
 Tyr Pro Phe Thr Phe Glu Ala Phe Phe Leu His Glu Asp Glu Ser Ser
                 245                 250                 255    
 Asp Ala Leu Pro Glu Trp Pro Val Leu Tyr Cys Glu Val Leu Ser Leu
             260                 265                 270        
 Asp Phe Trp Gln Arg Tyr Arg Val Glu Gly Tyr Gly Ala Val Val Leu
         275                 280                 285            
 Pro Ala Thr Pro Gly Ser His Thr Leu Thr Val Ser Thr Trp Arg Pro
     290                 295                 300                
 Val Glu Leu Gly Thr Val Ala Glu Leu Arg Arg Phe Phe Ile Gly Gly
 305                 310                 315                 320
 Ser Leu Glu Leu Glu Asp Leu Ser Tyr Val Arg Ile Pro Gly Ser Phe
                 325                 330                 335    
 Lys Gly Glu Arg Leu Ser Arg Phe Gly Leu Arg Thr Glu Thr Thr Gly
             340                 345                 350        
 Thr Val Thr Phe Arg Leu His Cys Leu Gln Gln Ser Arg Ala Phe Met
         355                 360                 365            
 Glu Ser Ser Ser Leu Gln Lys Arg Met Arg Ser Val Leu Asp Arg Leu
     370                 375                 380                
 Glu Gly Phe Ser Gln Gln Ser Ser Ile His Asn Val Leu Glu Ala Phe
 385                 390                 395                 400
 Arg Arg Ala Arg Arg Arg Met Gln Glu Ala Arg Glu Ser Leu Pro Gln
                 405                 410                 415    
 Asp Leu Val Ser Pro Ser Gly Thr Leu Val Ser
             420                 425        



      <210> 348
      <211> 289
      <212> PRT
      <213> Homo sapiens


      <400> 348
 Met Thr Thr Ala Ala Ser Glu Val Pro Ser Phe Leu Val Glu Arg Met
   1               5                  10                  15    
 Ala Asn Val Arg Arg Arg Arg Gln Asp Arg Arg Gly Met Glu Gly Gly
              20                  25                  30        
 Ile Leu Lys Ser Arg Ile Val Thr Trp Glu Pro Ser Glu Glu Phe Val
          35                  40                  45            
 Arg Asn Asn His Val Ile Asn Thr Pro Leu Gln Thr Met His Ile Met
      50                  55                  60                
 Ala Asp Leu Gly Pro Tyr Lys Lys Leu Gly Tyr Lys Lys Tyr Glu His
  65                  70                  75                  80
 Val Leu Cys Thr Leu Lys Val Asp Ser Asn Gly Val Ile Thr Val Lys
                  85                  90                  95    
 Pro Asp Phe Thr Gly Leu Lys Gly Pro Tyr Arg Ile Glu Thr Glu Gly
             100                 105                 110        
 Glu Lys Gln Glu Leu Trp Lys Tyr Thr Ile Asp Asn Val Ser Pro His
         115                 120                 125            
 Ala Gln Pro Glu Glu Glu Glu Arg Glu Arg Arg Val Phe Lys Asp Leu
     130                 135                 140                
 Tyr Gly Arg His Lys Glu Tyr Leu Ser Ser Leu Val Gly Thr Asp Phe
 145                 150                 155                 160
 Glu Met Thr Val Pro Gly Ala Leu Arg Leu Phe Val Asn Gly Glu Val
                 165                 170                 175    
 Val Ser Ala Gln Gly Tyr Glu Tyr Asp Asn Leu Tyr Val His Phe Phe
             180                 185                 190        
 Val Glu Leu Pro Thr Ala His Trp Ser Ser Pro Ala Phe Gln Gln Leu
         195                 200                 205            
 Ser Gly Val Thr Gln Thr Cys Thr Thr Lys Ser Leu Ala Met Asp Lys
     210                 215                 220                
 Val Ala His Phe Ser Tyr Pro Phe Thr Phe Glu Ala Phe Phe Leu His
 225                 230                 235                 240
 Glu Asp Glu Ser Ser Asp Ala Leu Pro Glu Trp Pro Val Leu Tyr Cys
                 245                 250                 255    
 Glu Val Leu Ser Leu Asp Phe Trp Gln Arg Tyr Arg Val Glu Gly Tyr
             260                 265                 270        
 Gly Ala Val Val Leu Pro Ala Thr Pro Ala Thr Met Thr Trp Pro Trp
         275                 280                 285            
 His
    



      <210> 349
      <211> 477
      <212> PRT
      <213> Homo sapiens


      <400> 349
 Met Thr Pro Glu Asp Pro Glu Glu Thr Gln Pro Leu Leu Gly Pro Pro
   1               5                  10                  15    
 Gly Gly Ser Ala Pro Arg Gly Arg Arg Val Phe Leu Ala Ala Phe Ala
              20                  25                  30        
 Ala Ala Leu Gly Pro Leu Ser Phe Gly Phe Ala Leu Gly Tyr Ser Ser
          35                  40                  45            
 Pro Ala Ile Pro Ser Leu Gln Arg Ala Ala Pro Pro Ala Pro Arg Leu
      50                  55                  60                
 Asp Asp Ala Ala Ala Ser Trp Phe Gly Ala Val Val Thr Leu Gly Ala
  65                  70                  75                  80
 Ala Ala Gly Gly Val Leu Gly Gly Trp Leu Val Asp Arg Ala Gly Arg
                  85                  90                  95    
 Lys Leu Ser Leu Leu Leu Cys Ser Val Pro Phe Val Ala Gly Phe Ala
             100                 105                 110        
 Val Ile Thr Ala Ala Gln Asp Val Trp Met Leu Leu Gly Gly Arg Leu
         115                 120                 125            
 Leu Thr Gly Leu Ala Cys Gly Val Ala Ser Leu Val Ala Pro Val Tyr
     130                 135                 140                
 Ile Ser Glu Ile Ala Tyr Pro Ala Val Arg Gly Leu Leu Gly Ser Cys
 145                 150                 155                 160
 Val Gln Leu Met Val Val Val Gly Ile Leu Leu Ala Tyr Leu Ala Gly
                 165                 170                 175    
 Trp Val Leu Glu Trp Arg Trp Leu Ala Val Leu Gly Cys Val Pro Pro
             180                 185                 190        
 Ser Leu Met Leu Leu Leu Met Cys Phe Met Pro Glu Thr Pro Arg Phe
         195                 200                 205            
 Leu Leu Thr Gln His Arg Arg Gln Glu Ala Met Ala Ala Leu Arg Phe
     210                 215                 220                
 Leu Trp Gly Ser Glu Gln Gly Trp Glu Asp Pro Pro Ile Gly Ala Glu
 225                 230                 235                 240
 Gln Ser Phe His Leu Ala Leu Leu Arg Gln Pro Gly Ile Tyr Lys Pro
                 245                 250                 255    
 Phe Ile Ile Gly Val Ser Leu Met Ala Phe Gln Gln Leu Ser Gly Val
             260                 265                 270        
 Asn Ala Val Met Phe Tyr Ala Glu Thr Ile Phe Glu Glu Ala Lys Phe
         275                 280                 285            
 Lys Asp Ser Ser Leu Ala Ser Val Val Val Gly Val Ile Gln Val Leu
     290                 295                 300                
 Phe Thr Ala Val Ala Ala Leu Ile Met Asp Arg Ala Gly Arg Arg Leu
 305                 310                 315                 320
 Leu Leu Val Leu Ser Gly Val Val Met Val Phe Ser Thr Ser Ala Phe
                 325                 330                 335    
 Gly Ala Tyr Phe Lys Leu Thr Gln Gly Gly Pro Gly Asn Ser Ser His
             340                 345                 350        
 Val Ala Ile Ser Ala Pro Val Ser Ala Gln Pro Val Asp Ala Ser Val
         355                 360                 365            
 Gly Leu Ala Trp Leu Ala Val Gly Ser Met Cys Leu Phe Ile Ala Gly
     370                 375                 380                
 Phe Ala Val Gly Trp Gly Pro Ile Pro Trp Leu Leu Met Ser Glu Ile
 385                 390                 395                 400
 Phe Pro Leu His Val Lys Gly Val Ala Thr Gly Ile Cys Val Leu Thr
                 405                 410                 415    
 Asn Trp Leu Met Ala Phe Leu Val Thr Lys Glu Phe Ser Ser Leu Met
             420                 425                 430        
 Glu Val Leu Arg Pro Tyr Gly Ala Phe Trp Leu Ala Ser Ala Phe Cys
         435                 440                 445            
 Ile Phe Ser Val Leu Phe Thr Leu Phe Cys Val Pro Glu Thr Lys Gly
     450                 455                 460                
 Lys Thr Leu Glu Gln Ile Thr Ala His Phe Glu Gly Arg
 465                 470                 475        



      <210> 350
      <211> 408
      <212> PRT
      <213> Homo sapiens


      <400> 350
 Met Thr Pro Glu Asp Pro Glu Glu Thr Gln Pro Leu Leu Gly Pro Pro
   1               5                  10                  15    
 Gly Gly Ser Ala Pro Arg Gly Arg Arg Val Phe Leu Ala Ala Phe Ala
              20                  25                  30        
 Ala Ala Leu Gly Pro Leu Ser Phe Gly Phe Ala Leu Gly Tyr Ser Ser
          35                  40                  45            
 Pro Ala Ile Pro Ser Leu Gln Arg Ala Ala Pro Pro Ala Pro Arg Leu
      50                  55                  60                
 Asp Asp Ala Ala Ala Ser Trp Phe Gly Val Tyr Ile Ser Glu Ile Ala
  65                  70                  75                  80
 Tyr Pro Ala Val Arg Gly Leu Leu Gly Ser Cys Val Gln Leu Met Val
                  85                  90                  95    
 Val Val Gly Ile Leu Leu Ala Tyr Leu Ala Gly Trp Val Leu Glu Trp
             100                 105                 110        
 Arg Trp Leu Ala Val Leu Gly Cys Val Pro Pro Ser Leu Met Leu Leu
         115                 120                 125            
 Leu Met Cys Phe Met Pro Glu Thr Pro Arg Phe Leu Leu Thr Gln His
     130                 135                 140                
 Arg Arg Gln Glu Ala Met Ala Ala Leu Arg Phe Leu Trp Gly Ser Glu
 145                 150                 155                 160
 Gln Gly Trp Glu Asp Pro Pro Ile Gly Ala Glu Gln Ser Phe His Leu
                 165                 170                 175    
 Ala Leu Leu Arg Gln Pro Gly Ile Tyr Lys Pro Phe Ile Ile Gly Val
             180                 185                 190        
 Ser Leu Met Ala Phe Gln Gln Leu Ser Gly Val Asn Ala Val Met Phe
         195                 200                 205            
 Tyr Ala Glu Thr Ile Phe Glu Glu Ala Lys Phe Lys Asp Ser Ser Leu
     210                 215                 220                
 Ala Ser Val Val Val Gly Val Ile Gln Val Leu Phe Thr Ala Val Ala
 225                 230                 235                 240
 Ala Leu Ile Met Asp Arg Ala Gly Arg Arg Leu Leu Leu Val Leu Ser
                 245                 250                 255    
 Gly Val Val Met Val Phe Ser Thr Ser Ala Phe Gly Ala Tyr Phe Lys
             260                 265                 270        
 Leu Thr Gln Gly Gly Pro Gly Asn Ser Ser His Val Ala Ile Ser Ala
         275                 280                 285            
 Pro Val Ser Ala Gln Pro Val Asp Ala Ser Val Gly Leu Ala Trp Leu
     290                 295                 300                
 Ala Val Gly Ser Met Cys Leu Phe Ile Ala Gly Phe Ala Val Gly Trp
 305                 310                 315                 320
 Gly Pro Ile Pro Trp Leu Leu Met Ser Glu Ile Phe Pro Leu His Val
                 325                 330                 335    
 Lys Gly Val Ala Thr Gly Ile Cys Val Leu Thr Asn Trp Leu Met Ala
             340                 345                 350        
 Phe Leu Val Thr Lys Glu Phe Ser Ser Leu Met Glu Val Leu Arg Pro
         355                 360                 365            
 Tyr Gly Ala Phe Trp Leu Ala Ser Ala Phe Cys Ile Phe Ser Val Leu
     370                 375                 380                
 Phe Thr Leu Phe Cys Val Pro Glu Thr Lys Gly Lys Thr Leu Glu Gln
 385                 390                 395                 400
 Ile Thr Ala His Phe Glu Gly Arg
                 405            



      <210> 351
      <211> 239
      <212> PRT
      <213> Homo sapiens


      <400> 351
 Met Ala Glu Asp Lys Thr Lys Pro Ser Glu Leu Asp Gln Gly Lys Tyr
   1               5                  10                  15    
 Asp Ala Asp Asp Asn Val Lys Ile Ile Cys Leu Gly Asp Ser Ala Val
              20                  25                  30        
 Gly Lys Ser Lys Leu Met Glu Arg Phe Leu Met Asp Gly Phe Gln Pro
          35                  40                  45            
 Gln Gln Leu Ser Thr Tyr Ala Leu Thr Leu Tyr Lys His Thr Ala Thr
      50                  55                  60                
 Val Asp Gly Lys Thr Ile Leu Val Asp Phe Trp Asp Thr Ala Gly Gln
  65                  70                  75                  80
 Glu Arg Phe Gln Ser Met His Ala Ser Tyr Tyr His Lys Ala His Ala
                  85                  90                  95    
 Cys Ile Met Val Phe Asp Val Gln Arg Lys Val Thr Tyr Arg Asn Leu
             100                 105                 110        
 Ser Thr Trp Tyr Thr Glu Leu Arg Glu Phe Arg Pro Glu Ile Pro Cys
         115                 120                 125            
 Ile Val Val Ala Asn Lys Ile Asp Ala Asp Ile Asn Val Thr Gln Lys
     130                 135                 140                
 Ser Phe Asn Phe Ala Lys Lys Phe Ser Leu Pro Leu Tyr Phe Val Ser
 145                 150                 155                 160
 Ala Ala Asp Gly Thr Asn Val Val Lys Val Trp Leu Thr Ala Glu Val
                 165                 170                 175    
 Ala Ser Lys Leu Phe Asn Asp Ala Ile Arg Leu Ala Val Ser Tyr Lys
             180                 185                 190        
 Gln Asn Ser Gln Asp Phe Met Asp Glu Ile Phe Gln Glu Leu Glu Asn
         195                 200                 205            
 Phe Ser Leu Glu Gln Glu Glu Glu Asp Val Pro Asp Gln Glu Gln Ser
     210                 215                 220                
 Ser Ser Ile Glu Thr Pro Ser Glu Glu Val Ala Ser Pro His Ser
 225                 230                 235                



      <210> 352
      <211> 302
      <212> PRT
      <213> Homo sapiens


      <400> 352
 Met Ala Glu Asp Lys Thr Lys Pro Ser Glu Leu Asp Gln Gly Lys Tyr
   1               5                  10                  15    
 Asp Ala Asp Asp Asn Val Lys Ile Ile Cys Leu Gly Asp Ser Ala Val
              20                  25                  30        
 Gly Lys Ser Lys Leu Met Glu Arg Phe Leu Met Asp Gly Leu Tyr Pro
          35                  40                  45            
 Ser Arg Phe Glu Val Leu Leu Val Pro Val Gly Leu Pro Thr Leu Met
      50                  55                  60                
 Tyr Gln Cys Pro Thr Ala His Pro Phe Val Pro Ala Ala Gln Glu Gln
  65                  70                  75                  80
 Glu Gly Gly Leu Asp Phe Asp Gly Gln Asp Thr Leu Ser Ser Pro Pro
                  85                  90                  95    
 Thr Pro His Pro Ser Met Glu Leu Val Pro Val Cys Ser Gln Pro Gln
             100                 105                 110        
 Gln Leu Ser Thr Tyr Ala Leu Thr Leu Tyr Lys His Thr Ala Thr Val
         115                 120                 125            
 Asp Gly Lys Thr Ile Leu Val Asp Phe Trp Asp Thr Ala Gly Gln Glu
     130                 135                 140                
 Arg Phe Gln Ser Met His Ala Ser Tyr Tyr His Lys Ala His Ala Cys
 145                 150                 155                 160
 Ile Met Val Phe Asp Ile Gln Arg Lys Val Thr Tyr Arg Asn Leu Ser
                 165                 170                 175    
 Thr Trp Tyr Thr Glu Leu Arg Glu Phe Arg Pro Glu Ile Pro Cys Ile
             180                 185                 190        
 Val Val Ala Asn Lys Ile Asp Ala Asp Ile Asn Val Thr Gln Lys Ser
         195                 200                 205            
 Phe Asn Phe Ala Lys Lys Phe Ser Leu Pro Leu Tyr Phe Val Ser Ala
     210                 215                 220                
 Ala Asp Gly Thr Asn Val Val Lys Val Trp Leu Thr Ala Glu Val Ala
 225                 230                 235                 240
 Ser Lys Leu Phe Asn Asp Ala Ile Arg Leu Ala Val Ser Tyr Lys Gln
                 245                 250                 255    
 Asn Ser Gln Asp Phe Met Asp Glu Ile Phe Gln Glu Leu Glu Asn Phe
             260                 265                 270        
 Ser Leu Glu Gln Glu Glu Glu Asp Val Pro Asp Gln Glu Gln Ser Ser
         275                 280                 285            
 Ser Ile Glu Thr Pro Ser Glu Glu Val Ala Ser Pro His Ser
     290                 295                 300        



      <210> 353
      <211> 101
      <212> PRT
      <213> Homo sapiens


      <400> 353
 Met Ala Glu Asp Leu Thr Lys Pro Ser Glu Leu Asp Gln Gly Lys Tyr
   1               5                  10                  15    
 Asp Ala Asp Asp Asn Val Lys Ile Ile Cys Leu Gly Asp Ser Ala Val
              20                  25                  30        
 Gly Lys Ser Lys Leu Met Glu Arg Phe Leu Met Asp Gly Phe Gln Pro
          35                  40                  45            
 Gln Gln Leu Ser Thr Tyr Ala Leu Thr Leu Tyr Lys His Thr Ala Thr
      50                  55                  60                
 Val Asp Gly Lys Thr Ile Leu Val Asp Phe Trp Asp Thr Ala Gly Gln
  65                  70                  75                  80
 Glu Arg Phe Gln Ser Met His Ala Ser Tyr Tyr His Lys Ala His Ala
                  85                  90                  95    
 Cys Ile Met Gln Thr
             100    



      <210> 354
      <211> 172
      <212> PRT
      <213> Homo sapiens


      <400> 354
 Met Leu Arg Tyr Val Glu Thr Leu Leu Thr His Met Gly Val Asn Pro
   1               5                  10                  15    
 Leu Glu Ala Glu Glu Leu Ile Arg Asp Glu Asp Ser Pro Asp Phe Glu
              20                  25                  30        
 Phe Ile Val Tyr Asp Ser Trp Lys Ile Thr Gly Arg Thr Ala Glu Asn
          35                  40                  45            
 Thr Phe Asn Lys Thr His Thr Phe His Phe Leu Leu Gly Ser Ile Tyr
      50                  55                  60                
 Gly Glu Cys Pro Val Pro Lys Pro Arg Val Asp Arg Pro Arg Lys Val
  65                  70                  75                  80
 Pro Val Ile Gln Glu Glu Arg Ala Met Pro Ala Gln Leu Arg Arg Met
                  85                  90                  95    
 Glu Glu Ser His Gln Glu Ala Thr Glu Lys Glu Val Glu Arg Ile Leu
             100                 105                 110        
 Gly Leu Leu Gln Thr Tyr Phe Arg Glu Asp Pro Asp Thr Pro Met Ser
         115                 120                 125            
 Phe Phe Asp Phe Val Val Asp Pro His Ser Phe Pro Arg Thr Val Glu
     130                 135                 140                
 Asn Ile Phe His Val Ser Phe Ile Ile Arg Asp Gly Phe Ala Arg Ile
 145                 150                 155                 160
 Arg Leu Asp Gln Asp Arg Leu Pro Val Ile Gly Lys
                 165                 170        



      <210> 355
      <211> 393
      <212> PRT
      <213> Homo sapiens


      <400> 355
 Met Asp Glu Asn Glu Ser Asn Gln Ser Leu Met Thr Ser Ser Gln Tyr
   1               5                  10                  15    
 Pro Lys Glu Ala Val Arg Lys Arg Gln Asn Ser Ala Arg Asn Ser Gly
              20                  25                  30        
 Ala Ser Asp Ser Ser Arg Phe Ser Arg Lys Ser Phe Lys Leu Asp Tyr
          35                  40                  45            
 Arg Leu Glu Glu Asp Val Thr Lys Ser Lys Lys Gly Lys Asp Gly Arg
      50                  55                  60                
 Phe Val Asn Pro Trp Pro Thr Trp Lys Asn Pro Ser Ile Pro Asn Val
  65                  70                  75                  80
 Leu Arg Trp Leu Ile Met Glu Lys Asp His Ser Ser Val Pro Ser Ser
                  85                  90                  95    
 Lys Glu Glu Leu Asp Lys Glu Leu Pro Val Leu Lys Pro Tyr Phe Ile
             100                 105                 110        
 Thr Asn Pro Glu Glu Ala Gly Val Arg Glu Ala Gly Leu Arg Val Thr
         115                 120                 125            
 Trp Leu Gly His Ala Thr Val Met Val Glu Met Asp Glu Leu Ile Phe
     130                 135                 140                
 Leu Thr Asp Pro Ile Phe Ser Ser Arg Ala Ser Pro Ser Gln Tyr Met
 145                 150                 155                 160
 Gly Pro Lys Arg Phe Arg Arg Ser Pro Cys Thr Ile Ser Glu Leu Pro
                 165                 170                 175    
 Pro Ile Asp Ala Val Leu Ile Ser His Asn His Tyr Asp His Leu Asp
             180                 185                 190        
 Tyr Asn Ser Val Ile Ala Leu Asn Glu Arg Phe Gly Asn Glu Leu Arg
         195                 200                 205            
 Trp Phe Val Pro Leu Gly Leu Leu Asp Trp Met Gln Lys Cys Gly Cys
     210                 215                 220                
 Glu Asn Val Ile Glu Leu Asp Trp Trp Glu Glu Asn Cys Val Pro Gly
 225                 230                 235                 240
 His Asp Lys Val Thr Phe Val Phe Thr Pro Ser Gln His Trp Cys Lys
                 245                 250                 255    
 Arg Thr Leu Met Asp Asp Asn Lys Val Leu Trp Gly Ser Trp Ser Val
             260                 265                 270        
 Leu Gly Pro Trp Asn Arg Phe Phe Phe Ala Gly Asp Thr Gly Tyr Cys
         275                 280                 285            
 Pro Ala Phe Glu Glu Ile Gly Lys Arg Phe Gly Pro Phe Asp Leu Ala
     290                 295                 300                
 Ala Ile Pro Ile Gly Ala Tyr Glu Pro Arg Trp Phe Met Lys Tyr Gln
 305                 310                 315                 320
 His Val Asp Pro Glu Glu Ala Val Arg Ile His Thr Asp Val Gln Thr
                 325                 330                 335    
 Lys Lys Ser Met Ala Ile His Trp Gly Thr Phe Ala Leu Ala Asn Glu
             340                 345                 350        
 His Tyr Leu Glu Pro Pro Val Lys Leu Asn Glu Ala Leu Glu Arg Tyr
         355                 360                 365            
 Gly Leu Asn Ala Glu Asp Phe Phe Val Leu Lys His Gly Glu Ser Arg
     370                 375                 380                
 Tyr Leu Asn Asn Asn Asp Glu Asn Phe
 385                 390            



      <210> 356
      <211> 386
      <212> PRT
      <213> Homo sapiens


      <400> 356
 Met Cys Ser Ser Val Ala Ala Lys Leu Trp Phe Leu Thr Asp Arg Arg
   1               5                  10                  15    
 Ile Arg Glu Asp Tyr Pro Gln Lys Glu Ile Leu Arg Ala Leu Lys Ala
              20                  25                  30        
 Lys Cys Cys Glu Glu Glu Leu Asp Phe Arg Ala Val Val Met Asp Glu
          35                  40                  45            
 Val Val Leu Thr Ile Glu Gln Gly Asn Leu Gly Leu Arg Ile Asn Gly
      50                  55                  60                
 Glu Leu Ile Thr Ala Tyr Pro Gln Val Val Val Val Arg Val Pro Thr
  65                  70                  75                  80
 Pro Trp Val Gln Ser Asp Ser Asp Ile Thr Val Leu Arg His Leu Glu
                  85                  90                  95    
 Lys Met Gly Cys Arg Leu Met Asn Arg Pro Gln Ala Ile Leu Asn Cys
             100                 105                 110        
 Val Asn Lys Phe Trp Thr Phe Gln Glu Leu Ala Gly His Gly Val Pro
         115                 120                 125            
 Leu Pro Asp Thr Phe Ser Tyr Gly Gly His Glu Asn Phe Ala Lys Met
     130                 135                 140                
 Ile Asp Glu Ala Glu Val Leu Glu Phe Pro Met Val Val Lys Asn Thr
 145                 150                 155                 160
 Arg Gly His Arg Gly Lys Ala Val Phe Leu Ala Arg Asp Lys His His
                 165                 170                 175    
 Leu Ala Asp Leu Ser His Leu Ile Arg His Glu Ala Pro Tyr Leu Phe
             180                 185                 190        
 Gln Lys Tyr Val Lys Glu Ser His Gly Arg Asp Val Arg Val Ile Val
         195                 200                 205            
 Val Gly Gly Arg Val Val Gly Thr Met Leu Arg Cys Ser Thr Asp Gly
     210                 215                 220                
 Arg Met Gln Ser Asn Cys Ser Leu Gly Gly Val Gly Met Met Cys Ser
 225                 230                 235                 240
 Leu Ser Glu Gln Gly Lys Gln Leu Ala Ile Gln Val Ser Asn Ile Leu
                 245                 250                 255    
 Gly Met Asp Val Cys Gly Ile Asp Leu Leu Met Lys Asp Asp Gly Ser
             260                 265                 270        
 Phe Cys Val Cys Glu Ala Asn Ala Asn Val Gly Phe Ile Ala Phe Asp
         275                 280                 285            
 Lys Ala Cys Asn Leu Asp Val Ala Gly Ile Ile Ala Asp Tyr Ala Ala
     290                 295                 300                
 Ser Leu Leu Pro Ser Gly Arg Leu Thr Arg Arg Met Ser Leu Leu Ser
 305                 310                 315                 320
 Val Val Ser Thr Ala Ser Glu Thr Ser Glu Pro Glu Leu Gly Pro Pro
                 325                 330                 335    
 Ala Ser Thr Ala Val Asp Asn Met Ser Ala Ser Ser Ser Ser Val Asp
             340                 345                 350        
 Ser Asp Pro Glu Ser Thr Glu Arg Glu Leu Leu Thr Lys Leu Pro Gly
         355                 360                 365            
 Gly Leu Phe Asn Met Asn Gln Leu Leu Ala Asn Glu Ile Lys Leu Leu
     370                 375                 380                
 Val Asp
 385    



      <210> 357
      <211> 41
      <212> PRT
      <213> Homo sapiens


      <400> 357
 Met Ser Lys Val Ser Phe Lys Ile Thr Leu Thr Ser Asp Pro Arg Leu
   1               5                  10                  15    
 Pro Tyr Lys Val Leu Ser Val Pro Glu Ser Thr Pro Phe Thr Ala Val
              20                  25                  30        
 Leu Lys Phe Ala Ala Glu Glu Met Glu
          35                  40    



      <210> 358
      <211> 295
      <212> PRT
      <213> Homo sapiens


      <400> 358
 Met Met Ala Lys Lys Pro Pro Lys Pro Ala Pro Arg Arg Ile Phe Gln
   1               5                  10                  15    
 Glu Arg Leu Lys Ile Thr Ala Leu Pro Leu Tyr Phe Glu Gly Phe Leu
              20                  25                  30        
 Leu Ile Lys Arg Ser Gly Tyr Arg Glu Tyr Glu His Tyr Trp Thr Glu
          35                  40                  45            
 Leu Arg Gly Thr Thr Leu Phe Phe Tyr Thr Asp Lys Lys Ser Ile Ile
      50                  55                  60                
 Tyr Val Asp Lys Leu Asp Ile Val Asp Leu Thr Cys Leu Thr Glu Gln
  65                  70                  75                  80
 Asn Ser Thr Glu Lys Asn Cys Ala Lys Phe Thr Leu Val Leu Pro Lys
                  85                  90                  95    
 Glu Glu Val Gln Leu Lys Thr Glu Asn Thr Glu Ser Gly Glu Glu Trp
             100                 105                 110        
 Arg Gly Phe Ile Leu Thr Val Thr Glu Leu Ser Val Pro Gln Asn Val
         115                 120                 125            
 Ser Leu Leu Pro Gly Gln Val Ile Lys Leu His Glu Val Leu Glu Arg
     130                 135                 140                
 Glu Lys Lys Arg Arg Ile Glu Thr Glu Gln Ser Thr Ser Val Glu Lys
 145                 150                 155                 160
 Glu Lys Glu Pro Thr Glu Asp Tyr Val Asp Val Leu Asn Pro Met Pro
                 165                 170                 175    
 Ala Cys Phe Tyr Thr Val Ser Arg Lys Glu Ala Thr Glu Met Leu Gln
             180                 185                 190        
 Lys Asn Pro Ser Leu Gly Asn Met Ile Leu Arg Pro Gly Ser Asp Ser
         195                 200                 205            
 Arg Asn Tyr Ser Ile Thr Ile Arg Gln Glu Ile Asp Ile Pro Arg Ile
     210                 215                 220                
 Lys His Tyr Lys Val Met Ser Val Gly Gln Asn Tyr Thr Ile Glu Leu
 225                 230                 235                 240
 Glu Lys Pro Val Thr Leu Pro Asn Leu Phe Ser Val Ile Asp Tyr Phe
                 245                 250                 255    
 Val Lys Glu Thr Arg Gly Asn Leu Arg Pro Phe Ile Cys Ser Thr Asp
             260                 265                 270        
 Glu Asn Thr Gly Gln Glu Pro Ser Met Glu Gly Arg Ser Glu Lys Leu
         275                 280                 285            
 Lys Lys Asn Pro His Ile Ala
     290                 295



      <210> 359
      <211> 767
      <212> PRT
      <213> Homo sapiens


      <400> 359
 Met Ala Arg Gly Ser Leu Gly Val Ser Pro Arg Ala Pro Leu Ala Ala
   1               5                  10                  15    
 Pro Arg Phe Ser Gln Cys Gly Met Trp Arg Val Cys Ala Phe Gln Thr
              20                  25                  30        
 Arg Ser Arg Leu Glu Cys Cys Val Cys Leu Arg Ser Glu Pro Val Gly
          35                  40                  45            
 Tyr Thr Gly Ser Asp Gly Arg Gly His Arg Pro His Ser Pro Ala Val
      50                  55                  60                
 Ala Leu Met Val Gln Ser Arg Val Trp Gln Trp Arg Val Pro Leu Val
  65                  70                  75                  80
 Thr Lys Asn Val Leu Arg Leu Gly Thr Gly Val Arg Gly Arg Pro Cys
                  85                  90                  95    
 Thr Arg Phe Gly Glu Ile Lys Ser Pro Ala Ala Ala Ile Asn Thr Leu
             100                 105                 110        
 Gln Phe Glu Tyr Ala Leu Cys Leu Gly Arg Val Gln Arg Pro Gly His
         115                 120                 125            
 Asp Phe Cys Val Pro Ala Glu Arg Gly Val Thr Glu Asp Val Arg Gly
     130                 135                 140                
 Cys Phe Arg Pro Glu Gly Gln Asp Met Leu Ala Leu Leu Leu Val Gly
 145                 150                 155                 160
 Arg Leu Ser Cys Pro Gln Pro Gly Leu Ser Ala Pro Val Thr Val Ser
                 165                 170                 175    
 Pro Arg Asp Cys Pro Thr Ile Pro Trp Trp Arg Gly Thr Gly Leu Leu
             180                 185                 190        
 Asp Leu Phe Thr Ala Val Pro Pro Ala Leu Ser Pro Val Pro Gly Trp
         195                 200                 205            
 Ala Glu Glu Gln Glu Arg Leu Arg Leu Glu Gln Glu Arg Glu Gln Glu
     210                 215                 220                
 Gln Lys Lys Ala Asn Ser Leu Ala Arg Leu Ala His Thr Leu Pro Val
 225                 230                 235                 240
 Glu Glu Pro Arg Met Glu Ala Pro Pro Leu Pro Leu Ser Pro Pro Ala
                 245                 250                 255    
 Pro Pro Pro Ala Pro Pro Pro Pro Leu Ala Thr Pro Ala Pro Leu Thr
             260                 265                 270        
 Val Ile Pro Ile Pro Val Val Thr Asn Ser Pro Gln Pro Leu Pro Pro
         275                 280                 285            
 Pro Pro Pro Leu Pro Ala Ala Ala Gln Pro Leu Pro Leu Ala Pro Arg
     290                 295                 300                
 Gln Pro Ala Leu Val Gly Ala Pro Gly Leu Ser Ile Lys Glu Pro Ala
 305                 310                 315                 320
 Pro Leu Pro Ser Arg Pro Gln Val Pro Thr Pro Ala Pro Leu Leu Pro
                 325                 330                 335    
 Asp Ser Lys Ala Thr Ile Pro Pro Asn Gly Ser Pro Lys Pro Leu Gln
             340                 345                 350        
 Pro Leu Pro Thr Pro Val Leu Thr Ile Ala Pro His Pro Gly Val Gln
         355                 360                 365            
 Pro Gln Leu Ala Pro Gln Gln Pro Pro Pro Pro Thr Leu Gly Thr Leu
     370                 375                 380                
 Lys Leu Ala Pro Ala Glu Glu Val Lys Ser Ser Glu Gln Lys Lys Arg
 385                 390                 395                 400
 Pro Gly Gly Ile Gly Thr Arg Glu Val His Asn Lys Leu Glu Lys Asn
                 405                 410                 415    
 Arg Arg Ala His Leu Lys Glu Cys Phe Glu Thr Leu Lys Arg Asn Ile
             420                 425                 430        
 Pro Asn Val Asp Asp Lys Lys Thr Ser Asn Leu Ser Val Leu Arg Thr
         435                 440                 445            
 Ala Leu Arg Tyr Ile Gln Ser Leu Lys Arg Lys Glu Lys Glu Tyr Glu
     450                 455                 460                
 His Glu Met Glu Arg Leu Ala Arg Glu Lys Ile Ala Thr Gln Gln Arg
 465                 470                 475                 480
 Leu Ala Glu Leu Lys His Glu Leu Ser Gln Trp Met Asp Val Leu Glu
                 485                 490                 495    
 Ile Asp Arg Val Leu Arg Gln Thr Gly Gln Pro Glu Asp Asp Gln Ala
             500                 505                 510        
 Ser Thr Ser Thr Ala Ser Glu Gly Glu Asp Asn Ile Asp Glu Asp Met
         515                 520                 525            
 Glu Glu Asp Arg Ala Gly Leu Gly Pro Pro Lys Leu Ser His Arg Pro
     530                 535                 540                
 Gln Pro Glu Leu Leu Lys Ser Thr Leu Pro Pro Pro Ser Thr Thr Pro
 545                 550                 555                 560
 Ala Pro Leu Pro Pro His Pro His Pro His Pro His Ser Val Ala Leu
                 565                 570                 575    
 Pro Pro Ala His Leu Pro Val Gln Gln Gln Gln Pro Gln Gln Lys Thr
             580                 585                 590        
 Pro Leu Pro Ala Pro Pro Pro Pro Pro Ala Ala Pro Ala Gln Thr Leu
         595                 600                 605            
 Val Pro Ala Pro Ala His Leu Val Ala Thr Ala Gly Gly Gly Ser Thr
     610                 615                 620                
 Val Ile Ala His Thr Ala Thr Thr His Ala Ser Val Ile Gln Thr Val
 625                 630                 635                 640
 Asn His Val Leu Gln Gly Pro Gly Gly Lys His Ile Ala His Ile Ala
                 645                 650                 655    
 Pro Ser Ala Pro Ser Pro Ala Val Gln Leu Ala Pro Ala Thr Pro Pro
             660                 665                 670        
 Ile Gly His Ile Thr Val His Pro Ala Thr Leu Asn His Val Ala His
         675                 680                 685            
 Leu Gly Ser Gln Leu Pro Leu Tyr Pro Gln Pro Val Ala Val Ser His
     690                 695                 700                
 Ile Ala His Thr Leu Ser His Gln Gln Val Asn Gly Thr Ala Gly Leu
 705                 710                 715                 720
 Gly Pro Pro Ala Thr Val Met Ala Lys Pro Ala Val Gly Ala Gln Val
                 725                 730                 735    
 Val His His Pro Gln Leu Val Gly Gln Thr Val Leu Asn Pro Val Thr
             740                 745                 750        
 Met Val Thr Met Pro Ser Phe Pro Val Ser Thr Leu Lys Leu Ala
         755                 760                 765        



      <210> 360
      <211> 69
      <212> PRT
      <213> Homo sapiens


      <400> 360
 Met Ala Gln Asp Leu Ser Glu Lys Asp Leu Leu Lys Met Glu Val Glu
   1               5                  10                  15    
 Gln Leu Lys Lys Glu Val Lys Asn Thr Arg Ile Pro Ile Ser Lys Ala
              20                  25                  30        
 Gly Lys Glu Ile Lys Glu Tyr Val Glu Ala Gln Ala Gly Asn Asp Pro
          35                  40                  45            
 Phe Leu Lys Gly Ile Pro Glu Asp Lys Asn Pro Phe Lys Glu Lys Gly
      50                  55                  60                
 Gly Cys Leu Ile Ser
  65                



      <210> 361
      <211> 418
      <212> PRT
      <213> Homo sapiens


      <400> 361
 Met Arg Leu Asn Ser Ser Ala Pro Gly Thr Pro Gly Thr Pro Ala Ala
   1               5                  10                  15    
 Asp Pro Phe Gln Arg Ala Gln Ala Gly Leu Glu Glu Ala Leu Leu Ala
              20                  25                  30        
 Pro Gly Phe Gly Asn Ala Ser Gly Asn Ala Ser Glu Arg Val Leu Ala
          35                  40                  45            
 Ala Pro Ser Ser Glu Leu Asp Val Asn Thr Asp Ile Tyr Ser Lys Val
      50                  55                  60                
 Leu Val Thr Ala Val Tyr Leu Ala Leu Phe Val Val Gly Thr Val Gly
  65                  70                  75                  80
 Asn Thr Val Thr Ala Phe Thr Leu Ala Arg Lys Lys Ser Leu Gln Ser
                  85                  90                  95    
 Leu Gln Ser Thr Val His Tyr His Leu Gly Ser Leu Ala Leu Ser Asp
             100                 105                 110        
 Leu Leu Thr Leu Leu Leu Ala Met Pro Val Glu Leu Tyr Asn Phe Ile
         115                 120                 125            
 Trp Val His His Pro Trp Ala Phe Gly Asp Ala Gly Cys Arg Gly Tyr
     130                 135                 140                
 Tyr Phe Leu Arg Asp Ala Cys Thr Tyr Ala Thr Ala Leu Asn Val Ala
 145                 150                 155                 160
 Ser Leu Ser Val Glu Arg Tyr Leu Ala Ile Cys His Pro Phe Lys Ala
                 165                 170                 175    
 Lys Thr Leu Met Ser Arg Ser Arg Thr Lys Lys Phe Ile Ser Ala Ile
             180                 185                 190        
 Trp Leu Ala Ser Ala Leu Leu Thr Val Pro Met Leu Phe Thr Met Gly
         195                 200                 205            
 Glu Gln Asn Arg Ser Ala Asp Gly Gln His Ala Gly Gly Leu Val Cys
     210                 215                 220                
 Thr Pro Thr Ile His Thr Ala Thr Val Lys Val Val Ile Gln Val Asn
 225                 230                 235                 240
 Thr Phe Met Ser Phe Ile Phe Pro Met Val Val Ile Ser Val Leu Asn
                 245                 250                 255    
 Thr Ile Ile Ala Asn Lys Leu Thr Val Met Val Arg Gln Ala Ala Glu
             260                 265                 270        
 Gln Gly Gln Val Cys Thr Val Gly Gly Glu His Ser Thr Phe Ser Met
         275                 280                 285            
 Ala Ile Glu Pro Gly Arg Val Gln Ala Leu Arg His Gly Val Arg Val
     290                 295                 300                
 Leu Arg Ala Val Val Ile Ala Phe Val Val Cys Trp Leu Pro Tyr His
 305                 310                 315                 320
 Val Arg Arg Leu Met Phe Cys Tyr Ile Ser Asp Glu Gln Trp Thr Pro
                 325                 330                 335    
 Phe Leu Tyr Asp Phe Tyr His Tyr Phe Tyr Met Val Thr Asn Ala Leu
             340                 345                 350        
 Phe Tyr Val Ser Ser Thr Ile Asn Pro Ile Leu Tyr Asn Leu Val Ser
         355                 360                 365            
 Ala Asn Phe Arg His Ile Phe Leu Ala Thr Leu Ala Cys Leu Cys Pro
     370                 375                 380                
 Val Trp Arg Arg Arg Arg Lys Arg Pro Ala Phe Ser Arg Lys Ala Asp
 385                 390                 395                 400
 Ser Val Ser Ser Asn His Thr Leu Ser Ser Asn Ala Thr Arg Glu Thr
                 405                 410                 415    
 Leu Tyr
        



      <210> 362
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 362
 Met Pro Lys Lys Ala Gly Ala Thr Thr Lys Gly Lys Ser Gln Ser Lys
   1               5                  10                  15    
 Glu Pro Glu Arg Pro Leu Pro Pro Leu Gly Pro Val Ala Val Asp Pro
              20                  25                  30        
 Lys Gly Cys Val Thr Ile Ala Ile His Ala Lys Pro Gly Ser Lys Gln
          35                  40                  45            
 Asn Ala Val Thr Asp Leu Thr Ala Glu Ala Val Asn Val Ala Ile Ala
      50                  55                  60                
 Ala Pro Pro Ser Glu Gly Glu Ala Asn Ala Glu Leu Cys Arg Tyr Leu
  65                  70                  75                  80
 Ser Lys Val Leu Glu Leu Arg Lys Ser Asp Val Val Leu Asp Lys Gly
                  85                  90                  95    
 Leu Ser Leu Cys His Pro Gly Trp Ser Thr Ala Ala Gln Pro Arg Val
             100                 105                 110        
 Thr Ala Ala Leu Thr Ser Leu Ala Gln Thr Ile Leu Pro Pro Gln Pro
         115                 120                 125            
 Pro Lys Leu Leu Glu Leu Gln Val His Ala Thr His Thr Arg Leu Ile
     130                 135                 140                
 Phe Val Phe Phe Glu Glu Thr Gly Ser Arg His Val Ala
 145                 150                 155        



      <210> 363
      <211> 51
      <212> PRT
      <213> Homo sapiens


      <400> 363
 Met Ser Gly Pro Leu Ser Pro Val Cys Ser Cys Pro Gln Leu Pro Phe
   1               5                  10                  15    
 Met Leu Ser Pro Cys His Met His His His Pro Gly His Val Ala Leu
              20                  25                  30        
 Ser Gln Thr Val Ser Pro Ala Ser Leu Leu Thr Gln Gly Leu Gly Leu
          35                  40                  45            
 Pro Gln His
      50    



      <210> 364
      <211> 189
      <212> PRT
      <213> Homo sapiens


      <400> 364
 Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu
   1               5                  10                  15    
 Gly Leu Glu Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly
              20                  25                  30        
 Ser Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro Gly Asn
          35                  40                  45            
 Glu Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Asn Ser Glu Thr Ser
      50                  55                  60                
 Pro Gly Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys
  65                  70                  75                  80
 Leu Gly Phe Ile Asn Trp Asp Ala Ile Asn Lys Asn Gln Val Pro Pro
                  85                  90                  95    
 Pro Ser Thr Arg Ala Leu Leu Tyr Phe Ser Arg Leu Trp Glu Asp Phe
             100                 105                 110        
 Lys Gln Asn Thr Pro Phe Leu Asn Trp Lys Ala Ile Ile Glu Gly Ala
         115                 120                 125            
 Asp Ala Ser Ser Leu Gln Lys Arg Ala Gly Arg Ala Asp Gln Asn Tyr
     130                 135                 140                
 Asn Tyr Asn Gln His Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser
 145                 150                 155                 160
 Val Lys Thr Pro Ala Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser
                 165                 170                 175    
 Arg Val Gln Pro Gly Leu Leu Gln Trp Val Lys Phe Trp
             180                 185                



      <210> 365
      <211> 386
      <212> PRT
      <213> Homo sapiens


      <400> 365
 Met Thr Arg Gln Cys Gln Ala Ser Asn Gln Gln Leu Gly Pro Gln Pro
   1               5                  10                  15    
 Leu Ala Thr Thr Pro Pro Asp Leu Phe Leu Gly Phe Gln Gln Leu Phe
              20                  25                  30        
 Gly Thr Phe Ala Ser Trp Gly Arg Glu Pro His Cys Gly Gly Pro Asp
          35                  40                  45            
 Phe Pro Gln Pro Ile Gln Thr Val Glu Asp Ala Leu Arg Lys Pro Ser
      50                  55                  60                
 Gly Leu Gln Leu Ile Asn Tyr Ile His Thr Tyr Leu Pro Leu Pro Ala
  65                  70                  75                  80
 Lys Tyr Gln Ile His Arg Thr Phe Arg Pro Ala Pro Pro Gly Gly Val
                  85                  90                  95    
 Ala Gly Val Leu Val Gly His Pro Phe Asp Thr Val Lys Val Arg Leu
             100                 105                 110        
 Gln Val Gln Ser Val Glu Lys Pro Gln Tyr Arg Gly Thr Leu His Cys
         115                 120                 125            
 Phe Lys Ser Ile Ile Lys Gln Glu Ser Val Leu Gly Leu Tyr Lys Gly
     130                 135                 140                
 Leu Gly Ser Pro Leu Met Gly Leu Thr Phe Ile Asn Ala Leu Val Phe
 145                 150                 155                 160
 Gly Val Gln Gly Asn Thr Leu Arg Ala Leu Gly His Asp Ser Pro Leu
                 165                 170                 175    
 Asn Gln Phe Leu Ala Gly Ala Ala Ala Gly Ala Ile Gln Cys Val Ile
             180                 185                 190        
 Cys Cys Pro Met Glu Leu Ala Lys Thr Arg Leu Gln Leu Gln Asp Ala
         195                 200                 205            
 Gly Pro Ala Arg Thr Tyr Lys Gly Ser Leu Asp Cys Leu Ala Gln Ile
     210                 215                 220                
 Tyr Gly His Glu Gly Leu Arg Gly Val Asn Arg Gly Met Val Ser Thr
 225                 230                 235                 240
 Leu Leu Arg Glu Thr Pro Ser Phe Gly Val Tyr Phe Leu Thr Tyr Asp
                 245                 250                 255    
 Ala Leu Thr Arg Ala Leu Gly Cys Glu Pro Gly Asp Arg Leu Leu Val
             260                 265                 270        
 Pro Lys Leu Leu Leu Ala Gly Gly Thr Ser Gly Ile Val Ser Trp Leu
         275                 280                 285            
 Ser Thr Tyr Pro Val Asp Val Val Lys Ser Arg Leu Gln Ala Asp Gly
     290                 295                 300                
 Leu Arg Gly Ala Pro Arg Tyr Arg Gly Ile Leu Asp Cys Val His Gln
 305                 310                 315                 320
 Ser Tyr Arg Ala Glu Gly Trp Arg Val Phe Thr Arg Gly Leu Ala Ser
                 325                 330                 335    
 Thr Leu Leu Arg Ala Phe Pro Val Asn Ala Ala Thr Phe Ala Thr Val
             340                 345                 350        
 Thr Val Val Leu Thr Tyr Ala Arg Gly Glu Glu Ala Gly Pro Glu Gly
         355                 360                 365            
 Glu Ala Val Pro Ala Ala Pro Ala Gly Pro Ala Leu Ala Gln Pro Ser
     370                 375                 380                
 Ser Leu
 385    



      <210> 366
      <211> 578
      <212> PRT
      <213> Homo sapiens


      <400> 366
 Met Leu Gln Asp Trp Cys Arg Arg Met Gly Val Asn Ala Glu Arg Ser
   1               5                  10                  15    
 Leu Leu Ile Leu Asp Ile Pro Asp Asp Cys Glu Glu His Glu Phe Gln
              20                  25                  30        
 Glu Ala Val Arg Ala Ala Leu Ser Pro Leu Gly Arg Tyr Arg Val Leu
          35                  40                  45            
 Ile Lys Val Phe Arg Lys Glu Leu Gly Ala Arg Ala Ala Leu Val Glu
      50                  55                  60                
 Phe Ala Glu Gly Leu Asn Gln Ser Leu Ile Pro Arg Gln Ile Ala Gly
  65                  70                  75                  80
 Lys Gly Gly Pro Trp Lys Val Ile Ser Leu Pro Gln Ala Leu Asp Ala
                  85                  90                  95    
 Glu Phe Gln Asp Ile Pro Ser Phe Pro Ala Gln Pro Gln Gly Gln Ala
             100                 105                 110        
 Val Ala Arg Gly Ala Gly Glu Ala Gly Ala Ala Gly Glu Ala Gly Ser
         115                 120                 125            
 Val Gly Glu Ala Gly Gly Val Asn Glu Glu Arg Ser Ala Gly Glu Asp
     130                 135                 140                
 Glu Ala Gly Gly Ile Gly Glu Ala Gly Gly Val Gly Glu Ala Gly Ala
 145                 150                 155                 160
 Ala Gly Glu Ala Gly Ala Ala Gly Glu Ala Gly Ala Ala Gly Glu Ala
                 165                 170                 175    
 Gly Gly Ala Gly Glu Ala Gly Gly Ala Gly Glu Ala Gly Gly Ala Gly
             180                 185                 190        
 Glu Glu Gly Gly Thr Gly Glu Glu Gly Gly Ala Gly Glu Ala Gly Gly
         195                 200                 205            
 Ala Gly Glu Glu Gly Gly Glu Asp Glu Ala Gly Ala Ala Gly Glu Ala
     210                 215                 220                
 Val Gly Ala Gly Val Val Glu Ala Trp Thr Gln Ser Trp Arg Gln Thr
 225                 230                 235                 240
 Leu Arg Pro Leu Val Lys Thr Met Ala Tyr Arg Glu Leu Arg Pro Phe
                 245                 250                 255    
 Ser Gly Arg Glu Gln Pro Gly Cys Val Glu Glu Ser Phe Glu Ser Trp
             260                 265                 270        
 Leu Glu Asp Ala Lys Asp Met Leu Gln Leu Trp Cys His Ala Ser Glu
         275                 280                 285            
 Arg Glu Arg Arg Arg Arg Leu Leu Asp Ser Leu Asp Gly Leu Ala Leu
     290                 295                 300                
 Asp Ile Val Ser Gly Leu Leu Glu Glu Asp Pro Asp Phe Ser Ala Gln
 305                 310                 315                 320
 Asp Cys Leu Thr Ala Leu Gly Gln Val Phe Arg Ser Arg Asp Thr Trp
                 325                 330                 335    
 Met Thr Ser Arg Met Lys Phe Leu Thr Cys Thr Gln Gly Pro Gln Glu
             340                 345                 350        
 Gly Leu Phe Ala Phe Val Val Arg Leu Glu Gly Leu Leu Gln Lys Ala
         355                 360                 365            
 Val Glu Lys Gly Ala Val His Pro Ala Met Ala Asn His Leu Arg Leu
     370                 375                 380                
 Arg Gln Val Leu Ser Arg Ala Arg Pro Ser Glu Ala Leu Gln Asp Thr
 385                 390                 395                 400
 Leu Arg Arg Met Gln Leu Glu Arg Arg Pro Pro Asp Phe Leu Arg Leu
                 405                 410                 415    
 Leu Arg Leu Ile Arg Asp Met Glu Ala Trp Ala Ala Ser Leu Ala Arg
             420                 425                 430        
 Ser Gln Gln Gly Val Ala Trp Ala Ala Ala Pro Val Glu Ser Glu Asp
         435                 440                 445            
 Pro Ala Ala Ala Gln Ala Ser Pro Ala Gln Gly Asp Ala Ser Glu Ala
     450                 455                 460                
 Asp Pro Gly Ala Glu Asp Ala Asp Glu Ala Ala Ser Thr Thr Lys Glu
 465                 470                 475                 480
 Ala Ala Arg Val Ala Pro Ala Thr Gly Glu Asp Glu Asn Ala Pro Ala
                 485                 490                 495    
 Gly Leu Glu Gly Leu Gly Gln Gly Arg Ser Pro Asp Ala Pro Gly Gly
             500                 505                 510        
 Leu Pro Ala Arg Met Gly Ser Ala Val Asp Met Ala Pro Gly Gly Pro
         515                 520                 525            
 Ser Trp Glu Pro Glu Gly Leu Val Gln Val Gly Gly Gln Glu Ala Glu
     530                 535                 540                
 Glu Pro Pro Gln Glu Gly Leu Lys Pro Ile Leu Glu Glu Ser Glu Asn
 545                 550                 555                 560
 Glu Asp Glu Asp Gly Ala Gly Glu Ala Gly Lys Pro Lys Ser Pro Pro
                 565                 570                 575    
 Gly Lys
        



      <210> 367
      <211> 426
      <212> PRT
      <213> Homo sapiens


      <400> 367
 Met Ser Ala Cys Asn Ile Ser Ile Gln Gly Pro Ser Ile Tyr Asn Lys
   1               5                  10                  15    
 Glu Pro Lys Asn Ile Ile Asn Pro His Glu Lys Val Gln Met Lys Ser
              20                  25                  30        
 Ile Cys Ala Asn Ser Pro Ile Lys Ala Gln Gln Asp Gln Leu Gln Val
          35                  40                  45            
 Lys Asn Asn Ile Lys Ala Ser Leu His Asn Val Lys Ser Ser Leu Pro
      50                  55                  60                
 Leu Phe Asn Thr Lys Ser Ser Thr Ser Val Gly Gln Leu Gln Ser Pro
  65                  70                  75                  80
 Thr Leu Asn Ser Pro Ile Tyr Met Gln Lys Gln Gly Lys Asn Glu His
                  85                  90                  95    
 Leu Ala Phe Asn Thr Lys Ser Lys Ala Ser Thr Val Gly Ser Glu Leu
             100                 105                 110        
 Val Leu Val Ser Thr Thr Val Pro Thr Val His His Val Ser Asp Leu
         115                 120                 125            
 Glu Met Ser Ser Thr Leu Asp Cys Leu Pro Val Leu Ala Asp Trp Glu
     130                 135                 140                
 Asp Val Val Leu Leu Pro Ala Ser Gln Pro Glu Glu Asn Val Asp Cys
 145                 150                 155                 160
 Thr Val Pro Ile Ser Asp Ser Asp Leu Glu Ile Ser Phe Asn Ser Gly
                 165                 170                 175    
 Glu Arg Leu Met Val Leu Lys Glu Leu Glu Met Ser Ser His Glu Asn
             180                 185                 190        
 Phe Gly Asp Ile Glu Glu Thr Pro Gln Lys Ser Glu Thr Ser Lys Ser
         195                 200                 205            
 Ile Val Tyr Lys Ser Pro His Thr Thr Ile Tyr Asn Val Lys Glu Ala
     210                 215                 220                
 Lys Asp Pro Gly Ser Asp Ile Ser Ala Phe Lys Leu Pro Glu His Lys
 225                 230                 235                 240
 Ser Ser Thr Phe Asn Arg Val Asn Ala Asn Met Ser His Pro Leu Val
                 245                 250                 255    
 Leu Gly Lys His Pro Leu Leu Ser Gly Gly Thr Lys Arg Asn Pro Cys
             260                 265                 270        
 Ser Pro Gln Ala Phe Pro Pro Ala Lys Lys Gln Pro Phe Thr Ile His
         275                 280                 285            
 Glu Glu Lys Pro Thr Ser Ser Asp Cys Ser Pro Val Arg Ser Ser Ser
     290                 295                 300                
 Trp Arg Arg Leu Pro Ser Ile Leu Thr Ser Thr Val Asn Leu Gln Glu
 305                 310                 315                 320
 Pro Trp Lys Ser Gly Lys Met Thr Pro Pro Leu Cys Lys Cys Gly Arg
                 325                 330                 335    
 Arg Ser Lys Arg Leu Val Val Ser Asn Asn Gly Pro Asn His Gly Lys
             340                 345                 350        
 Val Phe Tyr Cys Cys Pro Ile Gly Lys Tyr Gln Glu Asn Arg Lys Cys
         355                 360                 365            
 Cys Gly Tyr Phe Lys Trp Glu Gln Thr Leu Gln Lys Glu Arg Ala Asn
     370                 375                 380                
 Ser Met Val Pro Ser His Ser Thr Gly Gly Leu Thr Phe Ser Ser Pro
 385                 390                 395                 400
 Glu Thr Ser His Ile Cys Asp Arg Asn Leu Ser Ile Ser Thr Lys Asn
                 405                 410                 415    
 Ser Leu Arg Leu Arg Pro Ser Met Arg Asn
             420                 425    



      <210> 368
      <211> 316
      <212> PRT
      <213> Homo sapiens


      <400> 368
 Met Ser Asn Pro Phe Leu Lys Gln Val Phe Asn Lys Asp Lys Thr Phe
   1               5                  10                  15    
 Arg Pro Lys Arg Lys Phe Glu Pro Gly Thr Gln Arg Phe Glu Leu His
              20                  25                  30        
 Lys Lys Ala Gln Ala Ser Leu Asn Ala Gly Leu Asp Leu Arg Leu Ala
          35                  40                  45            
 Val Gln Leu Pro Pro Gly Glu Asp Leu Asn Asp Trp Val Ala Val His
      50                  55                  60                
 Val Val Asp Phe Phe Asn Arg Val Asn Leu Ile Tyr Gly Thr Ile Ser
  65                  70                  75                  80
 Asp Gly Cys Thr Glu Gln Ser Cys Pro Val Met Ser Gly Gly Pro Lys
                  85                  90                  95    
 Tyr Glu Tyr Arg Trp Gln Asp Glu His Lys Phe Arg Lys Pro Thr Ala
             100                 105                 110        
 Leu Ser Ala Pro Arg Tyr Met Asp Leu Leu Met Asp Trp Ile Glu Ala
         115                 120                 125            
 Gln Ile Asn Asn Glu Asp Leu Phe Pro Thr Asn Val Gly Thr Pro Phe
     130                 135                 140                
 Pro Lys Asn Phe Leu Gln Thr Val Arg Lys Ile Leu Ser Arg Leu Phe
 145                 150                 155                 160
 Arg Val Phe Val His Val Tyr Ile His His Phe Asp Arg Ile Ala Gln
                 165                 170                 175    
 Met Gly Ser Glu Ala His Val Asn Thr Cys Tyr Lys His Phe Tyr Tyr
             180                 185                 190        
 Phe Val Lys Glu Phe Gly Leu Ile Asp Thr Lys Glu Leu Glu Pro Leu
         195                 200                 205            
 Val Arg Gly Leu Gly Ala Glu Gly Val Arg Leu Arg Trp Arg Pro Arg
     210                 215                 220                
 Leu Glu Leu Gly Pro Gly Asp Pro Ala Asp Gly Thr Ser Gly Glu Val
 225                 230                 235                 240
 Ala Gly Arg Asp Pro Ala Phe Ser His Gly Thr Asn Ala Gly Asp Arg
                 245                 250                 255    
 Ser Glu Asn Ala Asp Ser Leu Ala Ser Trp Gly Ser Leu Leu Pro Leu
             260                 265                 270        
 Val Ser Glu Arg Asn Asp Arg Pro Asp Val Pro Leu Arg Ala Pro Arg
         275                 280                 285            
 Val Ser Arg Cys Pro Asn Arg Arg Trp Gly Leu Gly Asp Leu Glu Glu
     290                 295                 300                
 Asp Ala Leu Glu Pro Ser Ser Arg Phe Ser Pro Ala
 305                 310                 315    



      <210> 369
      <211> 267
      <212> PRT
      <213> Homo sapiens


      <400> 369
 Met Leu Gln Ser Thr Arg Pro Pro Arg Thr Ser Pro Ser Pro Arg Gly
   1               5                  10                  15    
 Cys Trp Pro Arg Arg Pro Pro Gly Pro Pro Ser Ala Arg Ala Arg Arg
              20                  25                  30        
 Arg Arg Arg Arg Arg Arg Arg Leu Cys Asn Ile Ser Val Gln Arg Gln
          35                  40                  45            
 Met Leu Ser Ser Leu Leu Val Arg Trp Gly Arg Pro Arg Gly Phe Gln
      50                  55                  60                
 Cys Asp Leu Leu Leu Phe Ser Thr Asn Ala His Gly Arg Ala Phe Phe
  65                  70                  75                  80
 Ala Ala Ala Phe His Arg Val Gly Pro Pro Leu Leu Ile Glu His Leu
                  85                  90                  95    
 Gly Leu Ala Ala Gly Gly Ala Gln Gln Asp Leu Arg Leu Cys Val Gly
             100                 105                 110        
 Cys Gly Trp Val Arg Gly Arg Arg Thr Gly Arg Leu Arg Pro Ala Ala
         115                 120                 125            
 Ala Pro Ser Ala Ala Ala Ala Thr Ala Gly Ala Pro Thr Ala Leu Pro
     130                 135                 140                
 Ala Tyr Pro Ala Ala Glu Pro Pro Gly Pro Leu Trp Leu Gln Gly Glu
 145                 150                 155                 160
 Pro Leu His Phe Cys Cys Leu Asp Phe Ser Leu Glu Glu Leu Gln Gly
                 165                 170                 175    
 Glu Pro Gly Trp Arg Leu Asn Arg Lys Pro Ile Glu Ser Thr Leu Val
             180                 185                 190        
 Ala Cys Phe Met Thr Leu Val Ile Val Val Trp Ser Val Ala Ala Leu
         195                 200                 205            
 Ile Trp Pro Val Pro Ile Ile Ala Gly Phe Leu Pro Asn Gly Met Glu
     210                 215                 220                
 Gln Arg Arg Thr Thr Ala Ser Thr Thr Ala Ala Thr Pro Ala Ala Val
 225                 230                 235                 240
 Pro Ala Gly Thr Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala
                 245                 250                 255    
 Ala Ala Ala Val Thr Ser Gly Val Ala Thr Lys
             260                 265        



      <210> 370
      <211> 164
      <212> PRT
      <213> Homo sapiens


      <400> 370
 Met Lys Cys Lys Pro Asn Gln Thr Arg Thr Tyr Asp Pro Glu Gly Phe
   1               5                  10                  15    
 Lys Lys Arg Ala Ala Cys Leu Cys Phe Arg Ser Glu Arg Glu Asp Glu
              20                  25                  30        
 Val Leu Leu Val Ser Ser Ser Arg Tyr Pro Asp Arg Trp Ile Val Pro
          35                  40                  45            
 Gly Gly Gly Met Glu Pro Glu Glu Glu Pro Gly Gly Ala Ala Val Arg
      50                  55                  60                
 Glu Val Tyr Glu Glu Ala Gly Val Lys Gly Lys Leu Gly Arg Leu Leu
  65                  70                  75                  80
 Gly Val Phe Glu Gln Asn Gln Asp Pro Lys His Arg Thr Tyr Val Tyr
                  85                  90                  95    
 Val Leu Thr Val Thr Glu Leu Leu Glu Asp Trp Glu Asp Ser Val Ser
             100                 105                 110        
 Ile Gly Arg Lys Arg Glu Trp Phe Lys Val Glu Asp Ala Ile Lys Val
         115                 120                 125            
 Leu Gln Cys His Lys Pro Val His Ala Glu Tyr Leu Glu Lys Leu Lys
     130                 135                 140                
 Leu Gly Gly Ser Pro Thr Asn Gly Asn Ser Met Ala Pro Ser Ser Pro
 145                 150                 155                 160
 Asp Ser Asp Pro
                



      <210> 371
      <211> 782
      <212> PRT
      <213> Homo sapiens


      <400> 371
 Met Met Leu Pro Tyr Pro Ser Ala Leu Gly Asp Gln Tyr Trp Glu Glu
   1               5                  10                  15    
 Ile Leu Leu Pro Lys Asn Gly Glu Asn Val Glu Thr Met Lys Lys Leu
              20                  25                  30        
 Thr Gln Asn His Lys Ala Lys Gly Leu Pro Ser Asn Asp Thr Asp Cys
          35                  40                  45            
 Pro Gln Lys Lys Glu Gly Lys Ala Gln Ile Val Val Pro Val Thr Phe
      50                  55                  60                
 Arg Asp Val Thr Val Ile Phe Thr Glu Ala Glu Trp Lys Arg Leu Ser
  65                  70                  75                  80
 Pro Glu Gln Arg Asn Leu Tyr Lys Glu Val Met Leu Glu Asn Tyr Arg
                  85                  90                  95    
 Asn Leu Leu Ser Leu Glu Asn Phe His Ser Ser Ala Glu Pro Lys Pro
             100                 105                 110        
 Glu Ile Tyr Thr Cys Ser Ser Cys Leu Leu Ala Phe Ser Cys Gln Gln
         115                 120                 125            
 Phe Leu Ser Gln His Val Leu Gln Ile Phe Leu Gly Leu Cys Ala Glu
     130                 135                 140                
 Asn His Phe His Pro Gly Asn Ser Ser Pro Gly His Trp Lys Gln Gln
 145                 150                 155                 160
 Gly Gln Gln Tyr Ser His Val Ser Cys Trp Phe Glu Asn Ala Glu Gly
                 165                 170                 175    
 Gln Glu Arg Gly Gly Gly Ser Lys Pro Trp Ser Ala Arg Thr Glu Glu
             180                 185                 190        
 Arg Glu Thr Ser Arg Ala Phe Pro Ser Pro Leu Gln Arg Gln Ser Ala
         195                 200                 205            
 Ser Pro Arg Lys Gly Asn Met Val Val Glu Thr Glu Pro Ser Ser Ala
     210                 215                 220                
 Gln Arg Pro Asn Pro Val Gln Leu Asp Lys Gly Leu Lys Glu Leu Glu
 225                 230                 235                 240
 Thr Leu Arg Phe Gly Ala Ile Asn Cys Arg Glu Tyr Glu Pro Asp His
                 245                 250                 255    
 Asn Leu Glu Ser Asn Phe Ile Thr Asn Pro Arg Thr Leu Leu Gly Lys
             260                 265                 270        
 Lys Pro Tyr Ile Cys Ser Asp Cys Gly Arg Ser Phe Lys Asp Arg Ser
         275                 280                 285            
 Thr Leu Ile Arg His His Arg Ile His Ser Met Glu Lys Pro Tyr Val
     290                 295                 300                
 Cys Ser Glu Cys Gly Arg Gly Phe Ser Gln Lys Ser Asn Leu Ser Arg
 305                 310                 315                 320
 His Gln Arg Thr His Ser Glu Glu Lys Pro Tyr Leu Cys Arg Glu Cys
                 325                 330                 335    
 Gly Gln Ser Phe Arg Ser Lys Ser Ile Leu Asn Arg His Gln Trp Thr
             340                 345                 350        
 His Ser Glu Glu Lys Pro Tyr Val Cys Ser Glu Cys Gly Arg Gly Phe
         355                 360                 365            
 Ser Glu Lys Ser Ser Phe Ile Arg His Gln Arg Thr His Ser Gly Glu
     370                 375                 380                
 Lys Pro Tyr Val Cys Leu Glu Cys Gly Arg Ser Phe Cys Asp Lys Ser
 385                 390                 395                 400
 Thr Leu Arg Lys His Gln Arg Ile His Ser Gly Glu Lys Pro Tyr Val
                 405                 410                 415    
 Cys Arg Glu Cys Gly Arg Gly Phe Ser Gln Asn Ser Asp Leu Ile Lys
             420                 425                 430        
 His Gln Arg Thr His Leu Asp Glu Lys Pro Tyr Val Cys Arg Glu Cys
         435                 440                 445            
 Gly Arg Gly Phe Cys Asp Lys Ser Thr Leu Ile Ile His Glu Arg Thr
     450                 455                 460                
 His Ser Gly Glu Lys Pro Tyr Val Cys Gly Glu Cys Gly Arg Gly Phe
 465                 470                 475                 480
 Ser Arg Lys Ser Leu Leu Leu Val His Gln Arg Thr His Ser Gly Glu
                 485                 490                 495    
 Lys His Tyr Val Cys Arg Glu Cys Arg Arg Gly Phe Ser Gln Lys Ser
             500                 505                 510        
 Asn Leu Ile Arg His Gln Arg Thr His Ser Asn Glu Lys Pro Tyr Ile
         515                 520                 525            
 Cys Arg Glu Cys Gly Arg Gly Phe Cys Asp Lys Ser Thr Leu Ile Val
     530                 535                 540                
 His Glu Arg Thr His Ser Gly Glu Lys Pro Tyr Val Cys Arg Cys Met
 545                 550                 555                 560
 Gly Lys Ala Phe Val Ile Thr His His Arg Glu Asn Leu His Val Gly
                 565                 570                 575    
 Thr Leu Trp Ser Ser Ala Gln Met Thr Phe Ser Gly Val Thr Pro Gln
             580                 585                 590        
 Leu Leu Glu Arg Thr Val Leu Leu Leu Ala Glu Met His Ser Arg Asp
         595                 600                 605            
 Ala Leu Arg Ser Gly Thr His Ser Gln Pro Gln Gly Ala Ala Cys Thr
     610                 615                 620                
 Thr Gly Ala Met His Leu Cys Arg Gly Thr Phe Trp Pro Gln Pro Leu
 625                 630                 635                 640
 Thr Gln Arg Gly Gln Leu Gln Lys Val Ile Pro Asp Pro Glu Ile Pro
                 645                 650                 655    
 Ile Glu Leu Lys Asp His Trp Val Ala Asp Thr Leu Gln Val Pro Pro
             660                 665                 670        
 Ile Asn Leu Ile Ile Met Ala Ile Glu Phe Gln His Glu Phe Trp Arg
         675                 680                 685            
 Arg His Ser His His Ser Ile Asn Tyr Ala Val Ala Pro Gln Ser Gly
     690                 695                 700                
 Leu Met Arg Glu Lys Asp Val His Val Trp Glu Cys Gly Pro Pro Pro
 705                 710                 715                 720
 Phe Ala Arg Thr Ala Pro Ile Thr Pro Thr Ser Asp Gln Asn Trp Arg
                 725                 730                 735    
 Pro Leu Arg Glu Lys Lys Gly His Tyr Gln Asp Leu Ser Thr Pro Ser
             740                 745                 750        
 Gln Lys Glu Thr Glu Leu Lys Arg Thr Arg Val Ser Leu Arg Arg Lys
         755                 760                 765            
 Arg Asp Ala Asn Ser Pro Leu Gln Asp Tyr Gly Phe Gly Ala
     770                 775                 780        



      <210> 372
      <211> 685
      <212> PRT
      <213> Homo sapiens


      <400> 372
 Met Ile Pro Gly Lys Tyr Arg Ser Val Ser Gly Arg Ala Ala Asn Asn
   1               5                  10                  15    
 Val Asn Cys Gly Leu His Leu Val Ile Gln Thr Ser Ser Leu Pro Glu
              20                  25                  30        
 Lys Asn Lys Val Glu Phe Lys Leu Asn Lys Asp Thr Ser Ser Phe Pro
          35                  40                  45            
 Gly Arg Leu Leu Gln His Asp Leu Glu Arg Asn Tyr Ser Ser Arg Gln
      50                  55                  60                
 Gly Asp His Ile Asn Leu Val Ser Ser Ser Leu Ser Ser Phe Pro Ile
  65                  70                  75                  80
 Leu Gln Arg Ser Ser Glu Glu Lys Ile Leu Tyr Ser Asp Arg Leu Ser
                  85                  90                  95    
 Leu Glu Arg Gln Lys Leu Thr Val Cys Pro Ile Ile Asn Gly Glu Asp
             100                 105                 110        
 His Leu Arg Leu Leu Asn Phe Gln His Asn Phe Ile Thr Arg Ile Gln
         115                 120                 125            
 Asn Ile Ser Asn Leu Gln Lys Leu Ile Ser Leu Asp Leu Tyr Asp Asn
     130                 135                 140                
 Gln Ile Glu Glu Ile Ser Gly Leu Ser Thr Leu Arg Cys Leu Arg Val
 145                 150                 155                 160
 Leu Leu Leu Gly Lys Asn Arg Ile Lys Lys Ile Ser Asn Leu Glu Asn
                 165                 170                 175    
 Leu Lys Ser Leu Asp Val Leu Asp Leu His Gly Asn Gln Ile Thr Lys
             180                 185                 190        
 Ile Glu Asn Ile Asn His Leu Cys Glu Leu Arg Val Leu Asn Leu Ala
         195                 200                 205            
 Arg Asn Phe Leu Ser His Val Asp Asn Leu Asn Gly Leu Asp Ser Leu
     210                 215                 220                
 Thr Glu Leu Asn Leu Arg His Asn Gln Ile Thr Phe Val Arg Asp Val
 225                 230                 235                 240
 Asp Asn Leu Pro Cys Leu Gln His Leu Phe Leu Ser Phe Asn Asn Ile
                 245                 250                 255    
 Ser Ser Phe Asp Ser Val Ser Cys Leu Ala Asp Ser Ser Ser Leu Ser
             260                 265                 270        
 Asp Thr Thr Phe Asp Gly Asn Pro Ile Ala Gln Glu Ser Trp Tyr Lys
         275                 280                 285            
 His Thr Val Leu Gln Asn Met Met Gln Leu Arg Gln Leu Asp Met Lys
     290                 295                 300                
 Arg Ile Thr Glu Glu Glu Arg Arg Met Ala Ser Val Leu Ala Lys Lys
 305                 310                 315                 320
 Glu Glu Glu Lys Lys Arg Glu Ser His Lys Gln Ser Leu Leu Lys Glu
                 325                 330                 335    
 Lys Lys Arg Leu Thr Ile Asn Asn Val Ala Arg Gln Trp Asp Leu Gln
             340                 345                 350        
 Gln Arg Val Ala Asn Ile Ala Thr Asn Glu Asp Arg Lys Asp Ser Asp
         355                 360                 365            
 Ser Pro Gln Asp Pro Cys Gln Ile Asp Gly Ser Thr Leu Ser Ala Phe
     370                 375                 380                
 Pro Glu Glu Thr Gly Pro Leu Asp Ser Gly Leu Asn Asn Ala Leu Gln
 385                 390                 395                 400
 Gly Leu Ser Val Ile Asp Thr Tyr Leu Val Glu Val Asp Gly Asp Thr
                 405                 410                 415    
 Leu Ser Leu Tyr Gly Ser Gly Ala Leu Glu Ser Leu Asp Arg Asn Trp
             420                 425                 430        
 Ser Val Gln Thr Ala Gly Met Ile Thr Thr Val Ser Phe Thr Phe Ile
         435                 440                 445            
 Glu Phe Asp Glu Ile Val Gln Val Leu Pro Lys Leu Lys Ile Lys Phe
     450                 455                 460                
 Pro Asn Ser Leu His Leu Lys Phe Lys Glu Thr Asn Leu Val Met Leu
 465                 470                 475                 480
 Gln Gln Phe Asn Ala Leu Ala Gln Leu Arg Arg Ile Asp Gln Leu Thr
                 485                 490                 495    
 Ile Asp Pro Gln Gly Asn Pro Val Val Asn Phe Thr Leu Trp Lys Tyr
             500                 505                 510        
 Tyr Val Leu Phe Arg Leu Ser His Phe Ser Met Gln Lys Ile Asn Gly
         515                 520                 525            
 Thr Glu Val Thr Gln Asn Asp Met Ile Met Ala Glu Arg Leu Phe Gly
     530                 535                 540                
 Ile Leu Ala His Val Ala Ser Ser Glu Leu Pro Gln Tyr Arg Leu Ile
 545                 550                 555                 560
 Ser Ile Leu Gly Asp Ala Arg Lys Lys Gln Phe Arg Tyr Leu Leu Glu
                 565                 570                 575    
 Ser Lys Gly Lys Lys Pro Gly Ile Ile Asn Glu Glu Asn Asn Asp Ser
             580                 585                 590        
 Lys Arg Leu Val Gly Glu Asn Thr Asn Arg Ala Thr Leu Asn Tyr Thr
         595                 600                 605            
 Thr Arg Asp Phe Tyr Asn Glu Lys Leu Glu Glu Ile Lys Glu Lys Lys
     610                 615                 620                
 Lys Phe Cys Lys Thr Tyr Ile Glu Asp Leu Val Lys Glu Ala Thr Glu
 625                 630                 635                 640
 Ile Asn Met Lys Asn Glu Ala Leu Gln Lys Leu Trp Pro Gln Met Phe
                 645                 650                 655    
 Ile Glu Leu Val Arg Asp Ala Val Ile Glu Ile Arg Asn Lys Asn Ser
             660                 665                 670        
 Tyr Met Lys Leu Cys Leu Gln Gln Ile Thr Asp Gln Lys
         675                 680                 685



      <210> 373
      <211> 137
      <212> PRT
      <213> Homo sapiens


      <400> 373
 Met Ala Gly Val Lys Ala Leu Val Ala Leu Ser Phe Ser Gly Ala Ile
   1               5                  10                  15    
 Gly Leu Thr Phe Leu Met Leu Gly Cys Ala Leu Glu Asp Tyr Gly Leu
              20                  25                  30        
 Gly Pro Thr Asp Ser Val Tyr Trp Pro Leu Phe Val Leu Ile Phe His
          35                  40                  45            
 Ala Ile Ser Pro Ile Pro His Phe Ile Ala Lys Arg Val Thr Tyr Asp
      50                  55                  60                
 Ser Asp Ala Thr Ser Ser Ala Cys Arg Glu Leu Ala Tyr Phe Phe Thr
  65                  70                  75                  80
 Thr Gly Ile Val Val Ser Ala Phe Gly Phe Pro Val Ile Leu Ala Arg
                  85                  90                  95    
 Val Ala Val Ile Lys Trp Gly Ala Cys Gly Leu Val Leu Ala Gly Asn
             100                 105                 110        
 Ala Val Ile Phe Leu Thr Ile Gln Gly Phe Phe Leu Ile Phe Gly Arg
         115                 120                 125            
 Gly Asp Asp Phe Ser Trp Glu Gln Trp
     130                 135        



      <210> 374
      <211> 200
      <212> PRT
      <213> Homo sapiens


      <400> 374
 Met Gly Ser Arg Glu Ser Val Glu Gly Ser Gly Arg Ser Gly Gly Ser
   1               5                  10                  15    
 Pro Phe Leu Pro Phe Ser Trp Phe Thr Asp Ser Gly Lys Gly Ser Ala
              20                  25                  30        
 Ser Ser Gly Ser Thr Thr Ser Pro Thr Cys Ser Pro Lys His Glu Gly
          35                  40                  45            
 Phe Ser Pro Lys Lys Ser Ala Ser Gln Glu Ser Thr Leu Ser Asp Asp
      50                  55                  60                
 Ser Thr Pro Pro Ser Ser Ser Pro Lys Ile Pro Ser Gly Pro Trp Gln
  65                  70                  75                  80
 Glu Ala Lys Cys Ser Tyr Pro Tyr His Thr Leu Ser Gln Ser Ser Asp
                  85                  90                  95    
 Glu Phe Leu Asp Glu Pro Leu Pro Pro Val His His Trp Thr Ser Gln
             100                 105                 110        
 Gln Val Gly Gln Trp Leu Gln Ser Leu Asn Leu Glu Gln Tyr Ala Ala
         115                 120                 125            
 Glu Phe Ala Ala Arg Gln Val Asp Gly Pro Gln Leu Leu Gln Leu Asp
     130                 135                 140                
 Gly Ser Lys Leu Lys Ser Leu Gly Leu Ser Asn Ser His Asp Arg Ala
 145                 150                 155                 160
 Leu Val Lys Arg Lys Leu Lys Glu Met Ala Ala Ala Ala Glu Lys Glu
                 165                 170                 175    
 Arg Lys Ala Gln Glu Lys Ala Ala Arg Gln Arg Glu Lys Leu Arg Arg
             180                 185                 190        
 Arg Glu Gln Glu Ala Lys Lys Ser
         195                 200



      <210> 375
      <211> 40
      <212> PRT
      <213> Homo sapiens


      <400> 375
 Met Ile Asn Leu Cys Ile Cys Phe Leu Lys Gly Glu Asp Gly Glu Lys
   1               5                  10                  15    
 Asn Arg Lys Leu Leu Ala Asp Ile Arg Gly His Lys Met Ser Ser Ser
              20                  25                  30        
 Phe Val Gln Met Thr Phe Ser Cys
          35                  40



      <210> 376
      <211> 832
      <212> PRT
      <213> Homo sapiens


      <400> 376
 Met His Lys Leu Asn Val Asn Leu Pro Arg Arg Lys Val Arg Gln Met
   1               5                  10                  15    
 Phe Gln Glu Ala Asp Thr Asp Glu Asn Gln Gly Thr Leu Thr Phe Glu
              20                  25                  30        
 Glu Phe Cys Val Phe Tyr Lys Met Met Ser Leu Arg Arg Asp Leu Tyr
          35                  40                  45            
 Leu Leu Leu Leu Ser Tyr Ser Asp Lys Lys Asp His Leu Thr Val Glu
      50                  55                  60                
 Glu Leu Ala Gln Phe Leu Lys Val Glu Gln Lys Met Asn Asn Val Thr
  65                  70                  75                  80
 Thr Asp Tyr Cys Leu Asp Ile Ile Lys Lys Phe Glu Val Ser Glu Glu
                  85                  90                  95    
 Asn Lys Val Lys Asn Val Leu Gly Ile Glu Gly Phe Thr Asn Phe Met
             100                 105                 110        
 Arg Ser Pro Ala Cys Asp Ile Phe Asn Pro Leu His His Glu Val Tyr
         115                 120                 125            
 Gln Asp Met Asp Gln Pro Leu Cys Asn Tyr Tyr Ile Ala Ser Ser His
     130                 135                 140                
 Asn Thr Tyr Leu Thr Gly Asp Gln Leu Leu Ser Gln Ser Lys Val Asp
 145                 150                 155                 160
 Met Tyr Ala Arg Val Leu Gln Glu Gly Cys Arg Cys Val Glu Val Asp
                 165                 170                 175    
 Cys Trp Asp Gly Pro Asp Gly Glu Pro Val Val His His Gly Tyr Thr
             180                 185                 190        
 Leu Thr Ser Lys Ile Leu Phe Arg Asp Val Val Glu Thr Ile Asn Lys
         195                 200                 205            
 His Ala Phe Val Lys Asn Glu Phe Pro Val Ile Leu Ser Ile Glu Asn
     210                 215                 220                
 His Cys Ser Ile Gln Gln Gln Arg Lys Ile Ala Gln Tyr Leu Lys Gly
 225                 230                 235                 240
 Ile Phe Gly Asp Lys Leu Asp Leu Ser Ser Val Asp Thr Gly Glu Cys
                 245                 250                 255    
 Lys Gln Leu Pro Ser Pro Gln Ser Leu Lys Gly Lys Ile Leu Val Lys
             260                 265                 270        
 Gly Lys Lys Leu Pro Tyr His Leu Gly Asp Asp Ala Glu Glu Gly Glu
         275                 280                 285            
 Val Ser Asp Glu Asp Ser Ala Asp Glu Ile Glu Asp Glu Cys Lys Phe
     290                 295                 300                
 Lys Leu His Tyr Ser Asn Gly Thr Thr Glu His Gln Val Glu Ser Phe
 305                 310                 315                 320
 Ile Arg Lys Lys Leu Glu Ser Leu Leu Lys Glu Ser Gln Ile Arg Asp
                 325                 330                 335    
 Lys Glu Asp Pro Asp Ser Phe Thr Val Arg Ala Leu Leu Lys Ala Thr
             340                 345                 350        
 His Glu Gly Leu Asn Ala His Leu Lys Gln Ser Pro Asp Val Lys Glu
         355                 360                 365            
 Ser Gly Lys Lys Ser His Gly Arg Ser Leu Met Thr Asn Phe Gly Lys
     370                 375                 380                
 His Lys Lys Thr Thr Lys Ser Arg Ser Lys Ser Tyr Ser Thr Asp Asp
 385                 390                 395                 400
 Glu Glu Asp Thr Gln Gln Ser Thr Gly Lys Glu Gly Gly Gln Leu Tyr
                 405                 410                 415    
 Arg Leu Gly Arg Arg Arg Lys Thr Met Lys Leu Cys Arg Glu Leu Ser
             420                 425                 430        
 Asp Leu Val Val Tyr Thr Asn Ser Val Ala Ala Gln Asp Ile Val Asp
         435                 440                 445            
 Asp Gly Thr Thr Gly Asn Val Leu Ser Phe Ser Glu Thr Arg Ala His
     450                 455                 460                
 Gln Val Val Gln Gln Lys Ser Glu Gln Phe Met Ile Tyr Asn Gln Lys
 465                 470                 475                 480
 Gln Leu Thr Arg Ile Tyr Pro Ser Ala Tyr Arg Ile Asp Ser Ser Asn
                 485                 490                 495    
 Phe Asn Pro Leu Pro Tyr Trp Asn Ala Gly Cys Gln Leu Val Ala Leu
             500                 505                 510        
 Asn Tyr Gln Ser Glu Gly Arg Met Met Gln Leu Asn Arg Ala Lys Phe
         515                 520                 525            
 Lys Ala Asn Gly Asn Cys Gly Tyr Val Leu Lys Pro Gln Gln Met Cys
     530                 535                 540                
 Lys Gly Thr Phe Asn Pro Phe Ser Gly Asp Pro Leu Pro Ala Asn Pro
 545                 550                 555                 560
 Lys Lys Gln Leu Ile Leu Lys Val Ile Ser Gly Gln Gln Leu Pro Lys
                 565                 570                 575    
 Pro Pro Asp Ser Met Phe Gly Asp Arg Gly Glu Ile Ile Asp Pro Phe
             580                 585                 590        
 Val Glu Val Glu Ile Ile Gly Leu Pro Val Asp Cys Cys Lys Asp Gln
         595                 600                 605            
 Thr Arg Val Val Asp Asp Asn Gly Phe Asn Pro Val Trp Glu Glu Thr
     610                 615                 620                
 Leu Thr Phe Thr Val His Met Pro Glu Ile Ala Leu Val Arg Phe Leu
 625                 630                 635                 640
 Val Trp Asp His Asp Pro Ile Gly Arg Asp Phe Val Gly Gln Arg Thr
                 645                 650                 655    
 Val Thr Phe Ser Ser Leu Val Pro Gly Tyr Arg His Val Tyr Leu Glu
             660                 665                 670        
 Gly Leu Thr Glu Ala Ser Ile Phe Val His Ile Thr Ile Asn Glu Ile
         675                 680                 685            
 Tyr Gly Lys Trp Ser Pro Leu Ile Leu Asn Pro Ser Tyr Thr Ile Leu
     690                 695                 700                
 His Phe Leu Gly Ala Thr Lys Asn Arg Gln Leu Gln Gly Leu Lys Gly
 705                 710                 715                 720
 Leu Phe Asn Lys Asn Pro Arg His Ser Ser Ser Glu Asn Asn Ser His
                 725                 730                 735    
 Tyr Val Arg Lys Arg Ser Ile Gly Asp Arg Ile Leu Arg Arg Thr Ala
             740                 745                 750        
 Ser Ala Pro Ala Lys Gly Arg Lys Lys Ser Lys Met Gly Phe Gln Glu
         755                 760                 765            
 Met Val Glu Ile Lys Asp Ser Val Ser Glu Ala Thr Arg Asp Gln Asp
     770                 775                 780                
 Gly Val Leu Arg Arg Thr Thr Arg Ser Leu Gln Ala Arg Pro Val Ser
 785                 790                 795                 800
 Met Pro Val Asp Arg Asn Leu Leu Gly Ala Leu Ser Leu Pro Val Ser
                 805                 810                 815    
 Glu Thr Ala Lys Asp Ile Glu Gly Lys Glu Asn Ser Leu Val Gln Ile
             820                 825                 830        





      <210> 377
      <211> 730
      <212> PRT
      <213> Homo sapiens


      <400> 377
 Met Pro Glu Pro Pro Pro Ala Pro Gly Ser Cys Ala Ala Arg Ala Ser
   1               5                  10                  15    
 Lys Thr Ser Ala Ala Pro Gly Ser Thr Ala Pro Ser Pro Ile His Arg
              20                  25                  30        
 Ser Arg Ala Glu Glu Arg Gly Thr Thr Ala Arg Asn Trp Gln Ala Ala
          35                  40                  45            
 Pro Thr Ala Ala Pro Val Arg Asp Pro Leu Gly Glu Ala Ser Trp Ala
      50                  55                  60                
 Pro Glu Ser Ala Asn Leu Val Gly Ile Trp Arg Thr Phe Val Ser Ser
  65                  70                  75                  80
 Ser Gly Ile Val Asn Ala Pro Ile Ser Thr Leu Ser Lys Arg Thr Asn
                  85                  90                  95    
 Gln Leu Ser Val Lys Gln Thr Asn Arg Leu Ser Val Lys Trp Thr Asn
             100                 105                 110        
 Gln Gln Asp Val Ala Arg Gly Ser Ala Thr Tyr Arg Glu Gly Glu His
         115                 120                 125            
 Gly Cys Trp Leu Leu Ala Pro Gly Gly Phe Arg Ala Leu Gln Leu Asp
     130                 135                 140                
 Asn Cys Arg Asp Gly Val Trp Leu Pro Asp Pro Leu Arg Gln Val Leu
 145                 150                 155                 160
 Gly Glu Ala Pro Pro Leu Gln Leu Ala Cys Arg Phe Pro Ser Gly Thr
                 165                 170                 175    
 Pro Ala Ala Ser Pro Glu Arg Gly Pro Gly Ala Glu Lys Arg Val Cys
             180                 185                 190        
 Gly Lys Asp Val Ser Glu Val Thr His Cys Thr His Asp Leu Leu His
         195                 200                 205            
 Ala Thr Leu Glu Asp Ser Trp Asp Val Ser Ser Gln Leu Asp Arg Gln
     210                 215                 220                
 Gln Glu Asn Trp Lys Arg His Leu Gly Ser Glu Ala Ser Thr Gln Lys
 225                 230                 235                 240
 Lys Ile Ile Thr Pro Gln Glu Asn Phe Glu Gln Asn Lys Phe Gly Glu
                 245                 250                 255    
 Asn Ser Arg Leu Asn Thr Asn Leu Val Thr Gln Leu Asn Ile Pro Ala
             260                 265                 270        
 Arg Ile Arg Pro Ser Glu Cys Glu Thr Leu Gly Ser Asn Leu Gly His
         275                 280                 285            
 Asn Ala Asp Leu Leu Asn Glu Asn Asn Ile Leu Ala Lys Lys Lys Pro
     290                 295                 300                
 Tyr Lys Cys Asp Lys Cys Arg Lys Ala Phe Ile His Arg Ser Ser Leu
 305                 310                 315                 320
 Thr Lys His Glu Lys Thr His Lys Gly Glu Gly Ala Phe Pro Asn Gly
                 325                 330                 335    
 Thr Asp Gln Gly Ile Tyr Pro Gly Lys Lys His His Glu Cys Thr Asp
             340                 345                 350        
 Cys Gly Lys Thr Phe Leu Trp Lys Thr Gln Leu Thr Glu His Gln Arg
         355                 360                 365            
 Ile His Thr Gly Glu Lys Pro Phe Glu Cys Asn Val Cys Gly Lys Ala
     370                 375                 380                
 Phe Arg His Ser Ser Ser Leu Gly Gln His Glu Asn Ala His Thr Gly
 385                 390                 395                 400
 Glu Lys Pro Tyr Gln Cys Ser Leu Cys Gly Lys Ala Phe Gln Arg Ser
                 405                 410                 415    
 Ser Ser Leu Val Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr
             420                 425                 430        
 Arg Cys Asn Leu Cys Gly Arg Ser Phe Arg His Gly Thr Ser Leu Thr
         435                 440                 445            
 Gln His Glu Val Thr His Ser Gly Glu Lys Pro Phe Gln Cys Lys Glu
     450                 455                 460                
 Cys Gly Lys Ala Phe Ser Arg Cys Ser Ser Leu Val Gln His Glu Arg
 465                 470                 475                 480
 Thr His Thr Gly Glu Lys Pro Phe Glu Cys Ser Ile Cys Gly Arg Ala
                 485                 490                 495    
 Phe Gly Gln Ser Pro Ser Leu Tyr Lys His Met Arg Ile His Lys Arg
             500                 505                 510        
 Gly Lys Pro Tyr Gln Ser Ser Asn Tyr Ser Ile Asp Phe Lys His Ser
         515                 520                 525            
 Thr Ser Leu Thr Gln Asp Glu Ser Thr Leu Thr Glu Val Lys Ser Tyr
     530                 535                 540                
 His Cys Asn Asp Cys Gly Glu Asp Phe Ser His Ile Thr Asp Phe Thr
 545                 550                 555                 560
 Asp His Gln Arg Ile His Thr Ala Glu Asn Pro Tyr Asp Cys Glu Gln
                 565                 570                 575    
 Ala Phe Ser Gln Gln Ala Ile Ser His Pro Gly Glu Lys Pro Tyr Gln
             580                 585                 590        
 Cys Asn Val Cys Gly Lys Ala Phe Lys Arg Ser Thr Ser Phe Ile Glu
         595                 600                 605            
 His His Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys
     610                 615                 620                
 Gly Glu Ala Phe Ser Arg Arg Ser Ser Leu Thr Gln His Glu Arg Thr
 625                 630                 635                 640
 His Thr Gly Glu Lys Pro Tyr Glu Cys Ile Asp Cys Gly Lys Ala Phe
                 645                 650                 655    
 Ser Gln Ser Ser Ser Leu Ile Gln His Glu Arg Thr His Thr Gly Glu
             660                 665                 670        
 Lys Pro Tyr Glu Cys Asn Glu Cys Gly Arg Ala Phe Arg Lys Lys Thr
         675                 680                 685            
 Asn Leu His Asp His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Ser
     690                 695                 700                
 Cys Lys Glu Cys Gly Lys Asn Phe Ser Arg Ser Ser Ala Leu Thr Lys
 705                 710                 715                 720
 His Gln Arg Ile His Thr Arg Asn Lys Leu
                 725                 730



      <210> 378
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 378
 Met Leu Ser Pro Glu Ala Glu Arg Val Leu Arg Tyr Leu Val Glu Val
   1               5                  10                  15    
 Glu Glu Leu Ala Glu Glu Val Leu Ala Asp Lys Arg Gln Ile Val Asp
              20                  25                  30        
 Leu Asp Thr Lys Arg Asn Gln Asn Arg Glu Gly Leu Arg Ala Leu Gln
          35                  40                  45            
 Lys Asp Leu Ser Leu Ser Glu Asp Val Met Val Cys Phe Gly Asn Met
      50                  55                  60                
 Phe Ile Lys Met Pro His Pro Glu Thr Lys Glu Met Ile Glu Lys Asp
  65                  70                  75                  80
 Gln Asp His Leu Asp Lys Glu Ile Glu Lys Leu Arg Lys Gln Leu Lys
                  85                  90                  95    
 Val Lys Val Asn Arg Leu Phe Glu Ala Gln Gly Lys Pro Glu Leu Lys
             100                 105                 110        
 Gly Phe Asn Leu Asn Pro Leu Asn Gln Asp Glu Leu Lys Ala Leu Lys
         115                 120                 125            
 Val Ile Leu Lys Gly
     130            



      <210> 379
      <211> 304
      <212> PRT
      <213> Homo sapiens


      <400> 379
 Met Ala Ala Ala Glu His Arg His Ser Ser Gly Leu Pro Tyr Trp Pro
   1               5                  10                  15    
 Tyr Leu Thr Ala Glu Thr Leu Lys Asn Arg Met Gly His Gln Pro Pro
              20                  25                  30        
 Pro Pro Thr Gln Gln His Ser Ile Thr Asp Asn Ser Leu Ser Leu Lys
          35                  40                  45            
 Thr Pro Pro Glu Cys Leu Leu Thr Pro Leu Pro Pro Ser Ala Leu Pro
      50                  55                  60                
 Ser Ala Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Arg Ala Glu Cys
  65                  70                  75                  80
 Leu Leu His Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Leu
                  85                  90                  95    
 Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala
             100                 105                 110        
 Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro
         115                 120                 125            
 Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr
     130                 135                 140                
 Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr
 145                 150                 155                 160
 Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn
                 165                 170                 175    
 Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala
             180                 185                 190        
 Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg
         195                 200                 205            
 Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu
     210                 215                 220                
 Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp
 225                 230                 235                 240
 Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser
                 245                 250                 255    
 Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr Pro Phe
             260                 265                 270        
 Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala
         275                 280                 285            
 Glu Arg Leu Arg Gly Ala Ser Ala Gly Ala Ala Ser Thr Leu Ser Gly
     290                 295                 300                





      <210> 380
      <211> 300
      <212> PRT
      <213> Homo sapiens


      <400> 380
 Met Ala Ala Ala Glu His Arg His Ser Ser Gly Leu Pro Tyr Trp Pro
   1               5                  10                  15    
 Tyr Leu Thr Ala Glu Thr Leu Lys Asn Arg Met Gly His Gln Pro Pro
              20                  25                  30        
 Pro Pro Thr Gln Gln His Ser Ile Thr Asp Asn Ser Leu Ser Leu Lys
          35                  40                  45            
 Thr Pro Pro Glu Cys Leu Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro
      50                  55                  60                
 Ser Ala Asp Asp Asn Leu Lys Thr Arg Ala Glu Cys Leu Leu His Pro
  65                  70                  75                  80
 Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Leu Ser Glu Arg Gln
                  85                  90                  95    
 Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile
             100                 105                 110        
 Lys Thr Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp
         115                 120                 125            
 Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro
     130                 135                 140                
 Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg
 145                 150                 155                 160
 Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro
                 165                 170                 175    
 Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala
             180                 185                 190        
 Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro
         195                 200                 205            
 Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr
     210                 215                 220                
 Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr
 225                 230                 235                 240
 Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn
                 245                 250                 255    
 Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr Pro Phe Pro Pro Ser Ala
             260                 265                 270        
 Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg
         275                 280                 285            
 Gly Ala Ser Ala Gly Ala Ala Ser Thr Leu Ser Gly
     290                 295                 300



      <210> 381
      <211> 512
      <212> PRT
      <213> Homo sapiens


      <400> 381
 Met Ala Ala Ala Glu His Arg His Ser Ser Gly Leu Pro Tyr Trp Pro
   1               5                  10                  15    
 Tyr Leu Thr Ala Glu Thr Leu Lys Asn Arg Met Gly His Gln Pro Pro
              20                  25                  30        
 Pro Pro Thr Gln Gln His Ser Ile Thr Asp Asn Ser Leu Ser Leu Lys
          35                  40                  45            
 Thr Pro Pro Glu Cys Leu Leu Thr Pro Leu Pro Pro Ser Ala Leu Pro
      50                  55                  60                
 Ser Ala Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Arg Ala Glu Cys
  65                  70                  75                  80
 Leu Leu His Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Leu
                  85                  90                  95    
 Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala
             100                 105                 110        
 Asp Asp Asn Ile Lys Thr Pro Ala Phe His Pro Gln Gln Met Ile Ile
         115                 120                 125            
 Ser Arg His Leu Pro Ser Val Ser Ser Leu Pro Phe His Pro Gln Leu
     130                 135                 140                
 His Pro Gln Gln Met Ile Ile Ser Arg His Leu Pro Ser Val Cys Gly
 145                 150                 155                 160
 Gly Arg Phe His Pro Gln Arg Met Ile Ile Ser Arg His Leu Pro Ser
                 165                 170                 175    
 Val Ser Ser Leu Pro Phe His Pro Gln Leu His Pro Gln Gln Met Ile
             180                 185                 190        
 Ile Ser Arg His Leu Pro Ser Val Cys Gly Gly Arg Phe His Pro Gln
         195                 200                 205            
 Arg Met Ile Ile Ser Arg His Leu Pro Ser Val Ser Ser Leu Pro Phe
     210                 215                 220                
 His Pro Gln Leu His Pro Gln Gln Met Ile Ile Ser Arg His Leu Pro
 225                 230                 235                 240
 Ser Val Cys Gly Gly Arg Phe His Pro Gln Arg Met Ile Ile Ser Arg
                 245                 250                 255    
 His Leu Pro Ser Val Ser Ser Leu Pro Phe His Pro Gln Leu His Pro
             260                 265                 270        
 Gln Gln Met Ile Ile Ser Arg His Leu Pro Ser Val Cys Gly Glu Arg
         275                 280                 285            
 Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro
     290                 295                 300                
 Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala
 305                 310                 315                 320
 Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro
                 325                 330                 335    
 Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr
             340                 345                 350        
 Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr
         355                 360                 365            
 Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn
     370                 375                 380                
 Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala
 385                 390                 395                 400
 Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg
                 405                 410                 415    
 Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu
             420                 425                 430        
 Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp
         435                 440                 445            
 Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser
     450                 455                 460                
 Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr Pro Phe
 465                 470                 475                 480
 Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala
                 485                 490                 495    
 Glu Arg Leu Arg Gly Ala Ser Ala Gly Ala Ala Ser Thr Leu Ser Gly
             500                 505                 510        





      <210> 382
      <211> 514
      <212> PRT
      <213> Homo sapiens


      <400> 382
 Met Ala Ala Ala Glu His Arg His Ser Ser Gly Leu Pro Tyr Trp Pro
   1               5                  10                  15    
 Tyr Leu Thr Ala Glu Thr Leu Lys Asn Arg Met Gly His Gln Pro Pro
              20                  25                  30        
 Pro Pro Thr Gln Gln His Ser Ile Thr Asp Asn Ser Leu Ser Leu Lys
          35                  40                  45            
 Thr Pro Pro Glu Cys Leu Leu Thr Pro Leu Pro Pro Ser Ala Leu Pro
      50                  55                  60                
 Ser Ala Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Arg Ala Glu Cys
  65                  70                  75                  80
 Leu Leu His Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Leu
                  85                  90                  95    
 Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala
             100                 105                 110        
 Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro
         115                 120                 125            
 Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr
     130                 135                 140                
 Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr
 145                 150                 155                 160
 Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn
                 165                 170                 175    
 Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala
             180                 185                 190        
 Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg
         195                 200                 205            
 Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu
     210                 215                 220                
 Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp
 225                 230                 235                 240
 Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser
                 245                 250                 255    
 Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr Pro Phe
             260                 265                 270        
 Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala
         275                 280                 285            
 Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys
     290                 295                 300                
 Thr Pro Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro
 305                 310                 315                 320
 Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg Gly Pro
                 325                 330                 335    
 Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln
             340                 345                 350        
 Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile
         355                 360                 365            
 Lys Thr Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp
     370                 375                 380                
 Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro
 385                 390                 395                 400
 Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg
                 405                 410                 415    
 Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro
             420                 425                 430        
 Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala
         435                 440                 445            
 Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro
     450                 455                 460                
 Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr
 465                 470                 475                 480
 Pro Phe Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr
                 485                 490                 495    
 Pro Ala Glu Arg Leu Arg Gly Ala Ser Ala Gly Ala Ala Ser Thr Leu
             500                 505                 510        
 Ser Gly
        



      <210> 383
      <211> 212
      <212> PRT
      <213> Homo sapiens


      <400> 383
 Met Ser Phe Glu Glu Leu Leu Glu Leu Gln Ser Gln Val Gly Thr Lys
   1               5                  10                  15    
 Thr Tyr Lys Gln Leu Val Ala Gly Asn Ser Pro Lys Lys Gln Ala Ser
              20                  25                  30        
 Arg Pro Pro Ile Gln Asn Ala Cys Val Ala Asp Lys His Arg Pro Leu
          35                  40                  45            
 Glu Met Ser Ala Lys Ile Arg Val Pro Phe Leu Arg Gln Val Val Pro
      50                  55                  60                
 Ile Ser Lys Lys Val Ala Arg Asp Pro Arg Phe Asp Asp Leu Ser Gly
  65                  70                  75                  80
 Glu Tyr Asn Pro Glu Val Phe Asp Lys Thr Tyr Gln Phe Leu Asn Asp
                  85                  90                  95    
 Ile Arg Ala Lys Glu Lys Glu Leu Val Lys Lys Gln Leu Lys Lys His
             100                 105                 110        
 Leu Ser Gly Glu Glu His Glu Lys Leu Gln Gln Leu Leu Gln Arg Met
         115                 120                 125            
 Glu Gln Gln Glu Met Ala Gln Gln Glu Arg Lys Gln Gln Gln Glu Leu
     130                 135                 140                
 His Leu Ala Leu Lys Gln Glu Arg Arg Ala Gln Ala Gln Gln Gly His
 145                 150                 155                 160
 Arg Pro Tyr Phe Leu Lys Lys Ser Glu Gln Arg Gln Leu Ala Leu Ala
                 165                 170                 175    
 Glu Lys Phe Lys Glu Leu Lys Arg Ser Lys Lys Leu Glu Asn Phe Leu
             180                 185                 190        
 Ser Arg Lys Arg Arg Arg Asn Ala Gly Lys Asp Arg Arg His Leu Pro
         195                 200                 205            
 Leu Ser Lys Glu
     210        



      <210> 384
      <211> 574
      <212> PRT
      <213> Homo sapiens


      <400> 384
 Met Tyr Thr Cys Asp Leu Ser Val Lys Glu Glu Leu Asp Val Val Glu
   1               5                  10                  15    
 Glu Ser His Tyr Ile Gln Gln Arg Val Gln Lys Ala Gln Phe Leu Val
              20                  25                  30        
 Glu Phe Glu Ser Gln Asn Lys Glu Phe Leu Met Glu Gln Gln Arg Thr
          35                  40                  45            
 Arg Asn Glu Gly Ala Trp Leu Arg Glu Pro Val Phe Pro Ser Ser Thr
      50                  55                  60                
 Lys Lys Lys Cys Pro Lys Leu Asn Lys Pro Gln Pro Gln Pro Ser Pro
  65                  70                  75                  80
 Leu Leu Ser Thr His His Thr Gln Glu Glu Asp Ile Ser Ser Lys Met
                  85                  90                  95    
 Ala Ser Val Val Ile Asp Asp Leu Pro Lys Glu Gly Glu Lys Gln Asp
             100                 105                 110        
 Leu Ser Ser Ile Lys Val Asn Val Thr Thr Leu Gln Asp Gly Lys Gly
         115                 120                 125            
 Thr Gly Ser Ala Asp Ser Ile Ala Thr Leu Pro Lys Gly Phe Gly Ser
     130                 135                 140                
 Val Glu Glu Leu Cys Thr Asn Ser Ser Leu Gly Met Glu Lys Ser Phe
 145                 150                 155                 160
 Ala Thr Lys Asn Glu Ala Val Gln Lys Glu Thr Leu Gln Glu Gly Pro
                 165                 170                 175    
 Lys Gln Glu Ala Leu Gln Glu Asp Pro Leu Glu Ser Phe Asn Tyr Val
             180                 185                 190        
 Leu Ser Lys Ser Thr Lys Ala Asp Ile Gly Pro Asn Leu Asp Gln Leu
         195                 200                 205            
 Lys Asp Asp Glu Ile Leu Arg His Cys Asn Pro Trp Pro Ile Ile Ser
     210                 215                 220                
 Ile Thr Asn Glu Ser Gln Asn Ala Glu Ser Asn Val Ser Ile Ile Glu
 225                 230                 235                 240
 Ile Ala Asp Asp Leu Ser Ala Ser His Ser Ala Leu Gln Asp Ala Gln
                 245                 250                 255    
 Ala Ser Glu Ala Lys Leu Glu Glu Glu Pro Ser Ala Ser Ser Pro Gln
             260                 265                 270        
 Tyr Ala Cys Asp Phe Asn Leu Phe Leu Glu Asp Ser Ala Asp Asn Arg
         275                 280                 285            
 Gln Asn Phe Ser Ser Gln Ser Leu Glu His Val Glu Lys Glu Asn Ser
     290                 295                 300                
 Leu Cys Gly Ser Ala Pro Asn Ser Arg Ala Gly Phe Val His Ser Lys
 305                 310                 315                 320
 Thr Cys Leu Ser Trp Glu Phe Ser Glu Lys Asp Asp Glu Pro Glu Glu
                 325                 330                 335    
 Val Val Val Lys Ala Lys Ile Arg Ser Lys Ala Arg Arg Ile Val Ser
             340                 345                 350        
 Asp Gly Glu Asp Glu Asp Asp Ser Phe Lys Asp Thr Ser Ser Ile Asn
         355                 360                 365            
 Pro Phe Asn Thr Ser Leu Phe Gln Phe Ser Ser Val Lys Gln Phe Asp
     370                 375                 380                
 Ala Ser Thr Pro Lys Asn Asp Ile Ser Pro Pro Gly Arg Phe Phe Ser
 385                 390                 395                 400
 Ser Gln Ile Pro Ser Ser Val Asn Lys Ser Met Asn Ser Arg Arg Ser
                 405                 410                 415    
 Leu Ala Ser Arg Arg Ser Leu Ile Asn Met Val Leu Asp His Val Glu
             420                 425                 430        
 Asp Met Glu Glu Arg Leu Asp Asp Ser Ser Glu Ala Lys Gly Pro Glu
         435                 440                 445            
 Asp Tyr Pro Glu Glu Gly Val Glu Glu Ser Ser Gly Glu Ala Ser Lys
     450                 455                 460                
 Tyr Thr Glu Glu Asp Pro Ser Gly Glu Thr Leu Ser Ser Glu Asn Lys
 465                 470                 475                 480
 Ser Ser Trp Leu Met Thr Ser Lys Pro Ser Ala Leu Ala Gln Glu Thr
                 485                 490                 495    
 Ser Leu Gly Ala Pro Glu Pro Leu Ser Gly Glu Gln Leu Val Gly Ser
             500                 505                 510        
 Pro Gln Asp Lys Ala Ala Glu Ala Thr Asn Asp Tyr Glu Thr Leu Val
         515                 520                 525            
 Lys Arg Gly Lys Glu Leu Lys Glu Cys Gly Lys Ile Gln Glu Ala Leu
     530                 535                 540                
 Asn Cys Leu Val Lys Ala Leu Asp Ile Lys Ser Ala Asp Pro Glu Val
 545                 550                 555                 560
 Met Leu Leu Thr Leu Ser Leu Tyr Lys Gln Leu Asn Asn Asn
                 565                 570                



      <210> 385
      <211> 395
      <212> PRT
      <213> Homo sapiens


      <400> 385
 Met Val Thr Arg Leu Tyr Asp Gly Met Arg Arg Val Asp Leu Thr Gly
   1               5                  10                  15    
 Lys Ala Lys Gly Pro Ser Glu Asn Val Ser Gln Glu Gln Phe Thr Ala
              20                  25                  30        
 Ser Met Ser His Leu Leu Lys Gly Asn Ser Glu Glu Lys Ser Leu Met
          35                  40                  45            
 Ile Met Lys Met Ile Ser Ala Thr Glu Gly Pro Val Lys Ala Arg Glu
      50                  55                  60                
 Val Gln Lys Phe Thr Glu Asp Leu Val Gly Ser Val Val His Val Leu
  65                  70                  75                  80
 Ser His Arg Gln Glu Leu Arg Gly Trp Thr Gly Lys Glu Ala Pro Gly
                  85                  90                  95    
 Pro Asn Pro Arg Val Gln Val Leu Ala Ala Gln Leu Leu Ser Glu Met
             100                 105                 110        
 Lys Leu Gln Asp Gly Lys Arg Leu Leu Gly Pro Gln Trp Leu Asp Tyr
         115                 120                 125            
 Asp Cys Asp Arg Ala Val Ile Glu Asp Trp Val Phe Arg Val Pro His
     130                 135                 140                
 Val Ala Ile Phe Leu Ser Val Val Ile Cys Lys Gly Phe Leu Val Leu
 145                 150                 155                 160
 Cys Ser Ser Leu Asp Leu Thr Thr Leu Val Pro Glu Arg Gln Val Asp
                 165                 170                 175    
 Gln Gly Arg Gly Phe Glu Ser Ile Leu Asp Val Leu Ser Val Met Tyr
             180                 185                 190        
 Ile Asn Ala Gln Leu Pro Arg Glu Gln Arg His Arg Trp Arg Leu Leu
         195                 200                 205            
 Phe Ser Ser Glu Leu His Gly His Ser Phe Ser Gln Leu Cys Gly His
     210                 215                 220                
 Ile Thr His Arg Gly Pro Cys Val Ala Val Leu Glu Asp His Asp Lys
 225                 230                 235                 240
 His Val Phe Gly Gly Phe Ala Ser Cys Ser Trp Glu Val Lys Pro Gln
                 245                 250                 255    
 Phe Gln Gly Asp Asn Arg Cys Phe Leu Phe Ser Ile Cys Pro Ser Met
             260                 265                 270        
 Ala Val Tyr Thr His Thr Gly Tyr Asn Asp His Tyr Met Tyr Leu Asn
         275                 280                 285            
 His Gly Gln Gln Thr Ile Pro Asn Gly Leu Gly Met Gly Gly Gln His
     290                 295                 300                
 Asn Tyr Phe Gly Leu Trp Val Asp Val Asp Phe Gly Lys Gly His Ser
 305                 310                 315                 320
 Arg Ala Lys Pro Thr Cys Thr Thr Tyr Asn Ser Pro Gln Leu Ser Ala
                 325                 330                 335    
 Gln Glu Asn Phe Gln Phe Asp Lys Met Glu Val Trp Ala Val Gly Asp
             340                 345                 350        
 Pro Ser Glu Glu Gln Leu Ala Lys Gly Asn Lys Ser Ile Leu Asp Ala
         355                 360                 365            
 Asp Pro Glu Ala Gln Ala Leu Leu Glu Ile Ser Gly His Ser Arg His
     370                 375                 380                
 Ser Glu Gly Leu Arg Glu Val Pro Asp Asp Glu
 385                 390                 395



      <210> 386
      <211> 561
      <212> PRT
      <213> Homo sapiens


      <400> 386
 Met Gly Phe Thr Thr Pro Pro Leu Asp Pro Val Leu Gln Asn Pro Leu
   1               5                  10                  15    
 Pro Ser Gln Leu Val Phe Ser Gly Leu Lys Thr Val Gln Pro Val Pro
              20                  25                  30        
 Pro Phe Tyr Arg Ser Leu Leu Thr Pro Gly Glu Met Val Ser Pro Pro
          35                  40                  45            
 Thr Ser Leu Pro Thr Ser Pro Ile Ile Pro Thr Ser Gly Thr Ile Glu
      50                  55                  60                
 Gln His Pro Pro Pro Pro Ser Glu Pro Val Val Pro Ala Val Met Met
  65                  70                  75                  80
 Ala Thr His Glu Pro Ser Ala Asp Leu Ala Pro Lys Lys Lys Pro Arg
                  85                  90                  95    
 Lys Ser Ser Met Pro Val Lys Ile Glu Lys Glu Ile Ile Asp Thr Ala
             100                 105                 110        
 Asp Glu Phe Asp Asp Glu Asp Asp Asp Pro Asn Asp Gly Gly Ala Val
         115                 120                 125            
 Val Asn Asp Met Ser His Asp Asn His Cys His Ser Gln Glu Glu Met
     130                 135                 140                
 Ser Pro Gly Met Ser Val Lys Asp Phe Ser Lys His Asn Arg Thr Arg
 145                 150                 155                 160
 Cys Ile Ser Arg Thr Glu Ile Arg Arg Ala Asp Ser Met Thr Ser Glu
                 165                 170                 175    
 Asp Gln Glu Pro Glu Arg Asp Tyr Glu Asn Glu Ser Glu Ser Ser Glu
             180                 185                 190        
 Pro Lys Leu Gly Glu Glu Ser Met Glu Gly Asp Glu His Ile His Ser
         195                 200                 205            
 Glu Val Ser Glu Lys Val Leu Met Asn Ser Glu Arg Pro Asp Glu Asn
     210                 215                 220                
 His Ser Glu Pro Ser His Gln Asp Val Ile Lys Val Lys Glu Glu Phe
 225                 230                 235                 240
 Thr Asp Pro Thr Tyr Asp Met Phe Tyr Met Ser Gln Tyr Gly Leu Tyr
                 245                 250                 255    
 Asn Gly Gly Gly Ala Ser Met Ala Ala Leu His Glu Ser Phe Thr Ser
             260                 265                 270        
 Ser Leu Asn Tyr Gly Ser Pro Gln Lys Phe Ser Pro Glu Gly Asp Leu
         275                 280                 285            
 Cys Ser Ser Pro Asp Pro Lys Ile Cys Tyr Val Cys Lys Lys Ser Phe
     290                 295                 300                
 Lys Ser Ser Tyr Ser Val Lys Leu His Tyr Arg Asn Val His Leu Lys
 305                 310                 315                 320
 Glu Met His Val Cys Thr Val Ala Gly Cys Asn Ala Ala Phe Pro Ser
                 325                 330                 335    
 Arg Arg Ser Arg Asp Arg His Ser Ala Asn Ile Asn Leu His Arg Lys
             340                 345                 350        
 Leu Leu Thr Lys Glu Leu Asp Asp Met Gly Leu Asp Ser Ser Gln Pro
         355                 360                 365            
 Ser Leu Ser Lys Asp Leu Arg Asp Glu Phe Leu Val Lys Ile Tyr Gly
     370                 375                 380                
 Ala Gln His Pro Met Gly Leu Asp Val Arg Glu Asp Ala Ser Ser Pro
 385                 390                 395                 400
 Ala Gly Thr Glu Asp Ser His Leu Asn Gly Tyr Gly Arg Gly Met Ala
                 405                 410                 415    
 Glu Asp Tyr Met Val Leu Asp Leu Ser Thr Thr Ser Ser Leu Gln Ser
             420                 425                 430        
 Ser Ser Ser Ile His Ser Ser Arg Glu Ser Asp Ala Gly Ser Asp Glu
         435                 440                 445            
 Gly Ile Leu Leu Asp Asp Ile Asp Gly Ala Ser Asp Ser Gly Glu Ser
     450                 455                 460                
 Ala His Lys Ala Glu Ala Pro Ala Leu Pro Gly Ser Leu Gly Ala Glu
 465                 470                 475                 480
 Val Ser Gly Ser Leu Met Phe Ser Ser Leu Ser Gly Ser Asn Gly Gly
                 485                 490                 495    
 Ile Met Cys Asn Ile Cys His Lys Met Tyr Ser Asn Lys Gly Thr Leu
             500                 505                 510        
 Arg Val His Tyr Lys Thr Val His Leu Arg Glu Met His Lys Cys Lys
         515                 520                 525            
 Val Pro Gly Cys Asn Met Met Phe Ser Ser Val Arg Ser Arg Asn Arg
     530                 535                 540                
 His Ser Gln Asn Pro Asn Leu His Lys Asn Ile Pro Phe Thr Ser Val
 545                 550                 555                 560
 Asp
    



      <210> 387
      <211> 104
      <212> PRT
      <213> Homo sapiens


      <400> 387
 Met Val Pro Leu Ser Gln Leu Ala Tyr Gly Pro Ala Val Pro Pro Gln
   1               5                  10                  15    
 Thr Leu Tyr Asn Pro Ala Gln Gln Ile Leu Ala Tyr Ala Gly Phe Arg
              20                  25                  30        
 Leu Thr Pro Glu Pro Val Pro Thr Cys Ser Ser Tyr Pro Leu Pro Leu
          35                  40                  45            
 Gln Pro Cys Ser Arg Phe Pro Val Ala Pro Ser Ser Ala Leu Ala Ser
      50                  55                  60                
 Ser Glu Asp Leu Gln Pro Pro Ser Pro Ser Ser Ser Gly Ser Gly Leu
  65                  70                  75                  80
 Pro Gly Gln Ala Pro Pro Cys Tyr Ala Pro Thr Tyr Phe Pro Pro Gly
                  85                  90                  95    
 Glu Lys Pro Pro Pro Tyr Ala Pro
             100                



      <210> 388
      <211> 532
      <212> PRT
      <213> Homo sapiens


      <400> 388
 Met Asn Lys Tyr Ile Pro Arg Asp Cys Ser Gln Lys Gly Arg Pro Phe
   1               5                  10                  15    
 His Leu Phe Arg Leu Leu Ile Gln Tyr His Glu Pro Glu Leu Cys Ser
              20                  25                  30        
 Tyr Leu Asp Thr Lys Lys Ile Thr Pro Asp Ser Tyr Ala Leu Asn Trp
          35                  40                  45            
 Leu Gly Ser Leu Phe Ala Cys Tyr Cys Ser Thr Glu Val Thr Gln Ala
      50                  55                  60                
 Ile Trp Asp Gly Tyr Leu Gln Gln Ala Asp Pro Phe Phe Ile Tyr Phe
  65                  70                  75                  80
 Leu Met Leu Ile Ile Leu Val Asn Ala Lys Glu Val Ile Leu Thr Gln
                  85                  90                  95    
 Glu Ser Asp Ser Lys Glu Glu Val Ile Lys Phe Leu Glu Asn Thr Pro
             100                 105                 110        
 Ser Ser Leu Asn Ile Glu Asp Ile Glu Asp Leu Phe Ser Leu Ala Gln
         115                 120                 125            
 Tyr Tyr Cys Ser Lys Thr Pro Ala Ser Phe Arg Lys Asp Asn His His
     130                 135                 140                
 Leu Phe Gly Ser Thr Leu Leu Gly Ile Lys Asp Asp Asp Ala Asp Leu
 145                 150                 155                 160
 Ser Gln Ala Leu Cys Leu Ala Ile Ser Val Ser Glu Ile Leu Gln Ala
                 165                 170                 175    
 Asn Gln Leu Gln Gly Glu Gly Val Arg Phe Phe Val Val Asp Cys Arg
             180                 185                 190        
 Pro Ala Glu Gln Tyr Asn Ala Gly His Leu Ser Thr Ala Phe His Leu
         195                 200                 205            
 Asp Ser Asp Leu Met Leu Gln Asn Pro Ser Glu Phe Ala Gln Ser Val
     210                 215                 220                
 Lys Ser Leu Leu Glu Ala Gln Lys Gln Ser Ile Glu Ser Gly Ser Ile
 225                 230                 235                 240
 Ala Gly Gly Glu His Leu Cys Phe Met Gly Ser Gly Arg Glu Glu Glu
                 245                 250                 255    
 Asp Met Tyr Met Asn Met Val Leu Ala His Phe Leu Gln Lys Asn Lys
             260                 265                 270        
 Glu Tyr Val Ser Ile Ala Ser Gly Gly Phe Met Ala Leu Gln Gln His
         275                 280                 285            
 Leu Ala Asp Ile Asn Val Asp Gly Pro Glu Asn Gly Tyr Gly His Trp
     290                 295                 300                
 Ile Ala Ser Thr Ser Gly Ser Arg Ser Ser Ile Asn Ser Val Asp Gly
 305                 310                 315                 320
 Glu Ser Pro Asn Gly Ser Ser Asp Arg Gly Met Lys Ser Leu Val Asn
                 325                 330                 335    
 Lys Met Thr Val Ala Leu Lys Thr Lys Ser Val Asn Val Arg Glu Lys
             340                 345                 350        
 Val Ile Ser Phe Ile Glu Asn Thr Ser Thr Pro Val Asp Arg His Val
         355                 360                 365            
 Ser Ser Ser Asp Arg Val Gly Lys Pro Tyr Arg Gly Val Lys Pro Val
     370                 375                 380                
 Phe Ser Ile Gly Asp Glu Glu Glu Tyr Asp Thr Asp Glu Ile Asp Ser
 385                 390                 395                 400
 Ser Ser Met Ser Asp Asp Asp Arg Lys Glu Val Val Asn Ile Gln Thr
                 405                 410                 415    
 Trp Ile Asn Lys Pro Asp Val Lys His His Phe Pro Cys Lys Glu Val
             420                 425                 430        
 Lys Glu Ser Gly His Met Phe Pro Ser His Leu Leu Val Thr Ala Thr
         435                 440                 445            
 His Met Tyr Cys Leu Arg Glu Ile Val Ser Arg Lys Gly Leu Ala Tyr
     450                 455                 460                
 Ile Gln Ser Arg Gln Ala Leu Asn Ser Val Val Lys Ile Thr Ser Lys
 465                 470                 475                 480
 Lys Lys His Pro Glu Leu Ile Thr Phe Lys Tyr Gly Asn Ser Ser Ala
                 485                 490                 495    
 Ser Gly Ile Glu Ile Leu Ala Ile Glu Arg Tyr Leu Ile Pro Asn Ala
             500                 505                 510        
 Gly Asp Ala Thr Lys Ala Ile Lys Gln Gln Ile Met Lys Val Leu Asp
         515                 520                 525            
 Ala Leu Glu Ser
     530        



      <210> 389
      <211> 370
      <212> PRT
      <213> Homo sapiens


      <400> 389
 Met Lys Ile Lys Asp Ala Lys Lys Pro Ser Phe Pro Trp Phe Gly Met
   1               5                  10                  15    
 Asp Ile Gly Gly Thr Leu Val Lys Leu Ser Tyr Phe Glu Pro Ile Asp
              20                  25                  30        
 Ile Thr Ala Glu Glu Glu Gln Glu Glu Val Glu Ser Leu Lys Ser Ile
          35                  40                  45            
 Arg Lys Tyr Leu Thr Ser Asn Val Ala Tyr Gly Ser Thr Gly Ile Arg
      50                  55                  60                
 Asp Val His Leu Glu Leu Lys Asp Leu Thr Leu Phe Gly Arg Arg Gly
  65                  70                  75                  80
 Asn Leu His Phe Ile Arg Phe Pro Thr Gln Asp Leu Pro Thr Phe Ile
                  85                  90                  95    
 Gln Met Gly Arg Asp Lys Asn Phe Ser Thr Leu Gln Thr Val Leu Cys
             100                 105                 110        
 Ala Thr Gly Gly Gly Ala Tyr Lys Phe Glu Lys Asp Phe Arg Thr Ile
         115                 120                 125            
 Gly Asn Leu His Leu His Lys Leu Asp Glu Leu Asp Cys Leu Val Lys
     130                 135                 140                
 Gly Leu Leu Tyr Ile Asp Ser Val Ser Phe Asn Gly Gln Ala Glu Cys
 145                 150                 155                 160
 Tyr Tyr Phe Ala Asn Ala Ser Glu Pro Glu Arg Cys Gln Lys Met Pro
                 165                 170                 175    
 Phe Asn Leu Asp Asp Pro Tyr Pro Leu Leu Val Val Asn Ile Gly Ser
             180                 185                 190        
 Gly Val Ser Ile Leu Ala Val His Ser Lys Asp Asn Tyr Lys Arg Val
         195                 200                 205            
 Thr Gly Thr Ser Leu Gly Gly Gly Thr Phe Leu Gly Leu Cys Ser Leu
     210                 215                 220                
 Leu Thr Gly Cys Glu Ser Phe Glu Glu Ala Leu Glu Met Ala Ser Lys
 225                 230                 235                 240
 Gly Asp Ser Thr Gln Ala Asp Lys Leu Val Arg Asp Ile Tyr Gly Gly
                 245                 250                 255    
 Asp Tyr Glu Arg Phe Gly Leu Pro Gly Trp Ala Val Ala Ser Ser Phe
             260                 265                 270        
 Gly Asn Met Ile Tyr Lys Glu Lys Arg Glu Ser Val Ser Lys Glu Asp
         275                 280                 285            
 Leu Ala Arg Ala Thr Leu Val Thr Ile Thr Asn Asn Ile Gly Ser Val
     290                 295                 300                
 Ala Arg Met Cys Ala Val Asn Glu Lys Ile Asn Arg Val Val Phe Val
 305                 310                 315                 320
 Gly Asn Phe Leu Arg Val Asn Thr Leu Ser Met Lys Leu Leu Ala Tyr
                 325                 330                 335    
 Ala Leu Asp Tyr Trp Ser Lys Gly Gln Leu Lys Ala Leu Phe Leu Glu
             340                 345                 350        
 His Glu Gly Tyr Phe Gly Ala Val Gly Ala Leu Leu Gly Leu Pro Asn
         355                 360                 365            
 Phe Ser
     370



      <210> 390
      <211> 340
      <212> PRT
      <213> Homo sapiens


      <400> 390
 Met Trp Lys Thr Thr Phe Ala Trp His Thr Glu Asp Met Asp Leu Tyr
   1               5                  10                  15    
 Ser Ile Asn Tyr Leu His Leu Gly Glu Pro Lys Thr Trp Tyr Val Val
              20                  25                  30        
 Pro Pro Glu His Gly Gln Arg Leu Glu Arg Leu Ala Arg Glu Leu Phe
          35                  40                  45            
 Pro Gly Ser Ser Arg Gly Cys Gly Ala Phe Leu Arg His Lys Val Ala
      50                  55                  60                
 Leu Ile Ser Pro Thr Val Leu Lys Glu Asn Gly Ile Pro Phe Asn Arg
  65                  70                  75                  80
 Ile Thr Gln Glu Ala Gly Glu Phe Met Val Thr Phe Pro Tyr Gly Tyr
                  85                  90                  95    
 His Ala Gly Phe Asn His Gly Phe Asn Cys Ala Glu Ala Ile Asn Phe
             100                 105                 110        
 Ala Thr Pro Arg Trp Ile Asp Tyr Gly Lys Met Ala Ser Gln Cys Ser
         115                 120                 125            
 Cys Gly Glu Ala Arg Val Thr Phe Ser Met Asp Ala Phe Val Arg Ile
     130                 135                 140                
 Leu Gln Pro Glu Arg Tyr Asp Leu Trp Lys Arg Gly Gln Asp Arg Ala
 145                 150                 155                 160
 Val Val Asp His Met Glu Pro Arg Val Pro Ala Ser Gln Glu Leu Ser
                 165                 170                 175    
 Thr Gln Lys Glu Val Gln Leu Pro Arg Arg Ala Ala Leu Gly Leu Arg
             180                 185                 190        
 Gln Leu Pro Ser His Trp Ala Arg His Ser Pro Trp Pro Met Ala Ala
         195                 200                 205            
 Arg Ser Gly Thr Arg Cys His Thr Leu Val Cys Ser Ser Leu Pro Arg
     210                 215                 220                
 Arg Ser Ala Val Ser Gly Thr Ala Thr Gln Pro Arg Ala Ala Ala Val
 225                 230                 235                 240
 His Ser Ser Lys Lys Pro Ser Ser Thr Pro Ser Ser Thr Pro Gly Pro
                 245                 250                 255    
 Ser Ala Gln Ile Ile His Pro Ser Asn Gly Arg Arg Gly Arg Gly Arg
             260                 265                 270        
 Pro Pro Gln Lys Leu Arg Ala Gln Glu Leu Thr Leu Gln Thr Pro Ala
         275                 280                 285            
 Lys Arg Pro Leu Leu Ala Gly Thr Thr Cys Thr Ala Ser Gly Pro Glu
     290                 295                 300                
 Pro Glu Pro Leu Pro Glu Asp Gly Ala Leu Met Asp Lys Pro Val Pro
 305                 310                 315                 320
 Leu Ser Pro Gly Leu Gln His Pro Val Lys Ala Ser Gly Cys Ser Trp
                 325                 330                 335    
 Ala Pro Val Pro
             340



      <210> 391
      <211> 316
      <212> PRT
      <213> Homo sapiens


      <400> 391
 Met Asp Trp Lys Leu Glu Gly Ser Thr Gln Lys Val Glu Ser Pro Val
   1               5                  10                  15    
 Leu Gln Gly Gln Glu Gly Ile Leu Glu Glu Thr Gly Glu Asp Gly Leu
              20                  25                  30        
 Pro Glu Gly Phe Gln Leu Leu Gln Ile Asp Ala Glu Gly Glu Cys Gln
          35                  40                  45            
 Glu Gly Glu Ile Leu Ala Thr Gly Ser Thr Ala Trp Cys Ser Lys Asn
      50                  55                  60                
 Val Gln Arg Lys Gln Arg His Trp Glu Lys Ile Val Ala Ala Lys Lys
  65                  70                  75                  80
 Ser Lys Arg Lys Gln Glu Lys Glu Arg Arg Lys Ala Asn Arg Ala Glu
                  85                  90                  95    
 Asn Pro Gly Ile Cys Pro Gln His Ser Lys Arg Phe Leu Arg Ala Leu
             100                 105                 110        
 Thr Lys Asp Lys Leu Leu Glu Ala Lys His Ser Gly Pro Arg Leu Cys
         115                 120                 125            
 Ile Asp Leu Ser Met Thr His Tyr Met Ser Lys Lys Glu Leu Ser Arg
     130                 135                 140                
 Leu Ala Gly Gln Ile Arg Arg Leu Tyr Gly Ser Asn Lys Lys Ala Asp
 145                 150                 155                 160
 Arg Pro Phe Trp Ile Cys Leu Thr Gly Phe Thr Thr Asp Ser Pro Leu
                 165                 170                 175    
 Tyr Glu Glu Cys Val Arg Met Asn Asp Gly Phe Ser Ser Tyr Leu Leu
             180                 185                 190        
 Asp Ile Thr Glu Glu Asp Cys Phe Ser Leu Phe Pro Leu Glu Thr Leu
         195                 200                 205            
 Val Tyr Leu Thr Pro Asp Ser Glu His Ala Leu Glu Asp Val Asp Leu
     210                 215                 220                
 Asn Lys Val Tyr Ile Leu Gly Gly Leu Val Asp Glu Ser Ile Gln Lys
 225                 230                 235                 240
 Lys Val Thr Phe Gln Lys Ala Arg Glu Tyr Ser Val Lys Thr Ala Arg
                 245                 250                 255    
 Leu Pro Ile Gln Glu Tyr Met Val Arg Asn Gln Asn Gly Lys Asn Tyr
             260                 265                 270        
 His Ser Glu Ile Leu Ala Ile Asn Gln Val Phe Asp Ile Leu Ser Thr
         275                 280                 285            
 Tyr Leu Glu Thr His Asn Trp Pro Glu Ala Leu Lys Lys Gly Val Ser
     290                 295                 300                
 Ser Gly Lys Gly Tyr Ile Leu Arg Asn Ser Val Glu
 305                 310                 315    



      <210> 392
      <211> 301
      <212> PRT
      <213> Homo sapiens


      <400> 392
 Met Arg Asp Lys Glu Ala Gly Leu Ala Gln Ala His Gln Gly Cys Gly
   1               5                  10                  15    
 Ile His Ala Ile Glu Leu Asn Pro Ser Lys Thr Leu Leu Ala Thr Gly
              20                  25                  30        
 Gly Glu Asn Pro Asn Ser Leu Ala Ile Tyr Gln Leu Pro Thr Leu Asp
          35                  40                  45            
 Pro Leu Cys Leu Gly Asp Arg His Gly His Lys Asp Trp Ile Phe Ala
      50                  55                  60                
 Val Ala Trp Leu Ser Asp Thr Val Ala Val Ser Gly Ser Arg Asp Gly
  65                  70                  75                  80
 Thr Val Ala Leu Trp Arg Met Asp Pro Asp Met Phe Asn Gly Ser Ile
                  85                  90                  95    
 Ala Trp His Ser Glu Val Gly Leu Pro Val Tyr Ala His Ile Arg Pro
             100                 105                 110        
 Arg Asp Val Glu Ala Ile Pro Arg Ala Ser Thr Asn Pro Ser Asn Arg
         115                 120                 125            
 Lys Val Arg Ala Leu Ala Phe Ser Gly Lys Asn Gln Glu Leu Gly Ala
     130                 135                 140                
 Val Ser Leu Asp Gly Tyr Phe His Cys Asp Glu Leu Ser Leu Tyr Ala
 145                 150                 155                 160
 Val Gly Ser Gln Ser His Val Ser Phe Leu Asp Pro Arg Gln Arg Gln
                 165                 170                 175    
 Gln Asn Ile Arg Pro Leu Cys Ser Arg Glu Gly Gly Thr Gly Val Arg
             180                 185                 190        
 Ser Leu Ser Phe Tyr Gln His Ile Ile Thr Val Gly Thr Gly His Gly
         195                 200                 205            
 Ser Leu Leu Phe Tyr Asp Ile Arg Ala Gln Lys Phe Leu Glu Glu Arg
     210                 215                 220                
 Ala Ser Ser Ser Leu Asp Ser Met Pro Gly Pro Ala Gly Arg Lys Leu
 225                 230                 235                 240
 Lys Leu Ala Cys Gly Arg Gly Trp Leu Asn Gln Asp Asp Val Trp Val
                 245                 250                 255    
 Asn Tyr Phe Gly Gly Met Gly Glu Phe Pro Asn Ala Leu Tyr Thr His
             260                 265                 270        
 Cys Tyr Asn Trp Pro Glu Met Lys Leu Phe Val Ala Gly Gly Pro Leu
         275                 280                 285            
 Pro Ser Gly Leu His Gly Asn Tyr Ala Gly Leu Trp Ser
     290                 295                 300    



      <210> 393
      <211> 539
      <212> PRT
      <213> Homo sapiens


      <400> 393
 Met Ala Ala Pro Ala Ser Arg Gln Val Arg Arg Arg Ala Arg Ala Ala
   1               5                  10                  15    
 Pro Arg Pro Arg Ser Ala Glu Asp Trp Trp Trp Asp Arg Leu Ala Pro
              20                  25                  30        
 Arg Gly Ser Gly Tyr His Leu Leu Gln Ser Asp Ser Met Leu Leu Val
          35                  40                  45            
 Leu Ser Glu Pro Gly Pro Ala Arg Pro Arg Ala Gln Arg Arg Ala Ser
      50                  55                  60                
 Arg Arg Thr Pro Arg Gln Pro Pro Arg Gly Pro Ser Ala Ala Ala Lys
  65                  70                  75                  80
 Pro Lys Ala Gly Leu Arg Ser Glu Ala Ala Ala Ala Pro Ala Pro Ala
                  85                  90                  95    
 Pro Ala Pro Thr Pro Thr Pro Glu Glu Gly Pro Asp Ala Gly Trp Gly
             100                 105                 110        
 Asp Arg Ile Pro Leu Glu Ile Leu Val Gln Ile Phe Gly Leu Leu Val
         115                 120                 125            
 Ala Ala Asp Gly Pro Met Pro Phe Leu Gly Arg Ala Ala Arg Val Cys
     130                 135                 140                
 Arg Arg Trp Gln Glu Ala Ala Ser Gln Pro Ala Leu Trp His Thr Val
 145                 150                 155                 160
 Thr Leu Ser Ser Pro Leu Val Gly Arg Pro Ala Lys Gly Gly Val Lys
                 165                 170                 175    
 Ala Glu Lys Lys Leu Leu Ala Ser Leu Glu Trp Leu Met Pro Asn Arg
             180                 185                 190        
 Phe Ser Gln Leu Gln Arg Leu Thr Leu Ile His Trp Lys Ser Gln Val
         195                 200                 205            
 His Pro Val Leu Lys Leu Val Gly Glu Cys Cys Pro Arg Leu Thr Phe
     210                 215                 220                
 Leu Lys Leu Ser Gly Cys His Gly Val Thr Ala Asp Ala Leu Val Met
 225                 230                 235                 240
 Leu Ala Lys Ala Cys Cys Gln Leu His Ser Leu Asp Leu Gln His Ser
                 245                 250                 255    
 Met Val Glu Ser Thr Ala Val Val Ser Phe Leu Glu Glu Ala Gly Ser
             260                 265                 270        
 Arg Met Arg Lys Leu Trp Leu Thr Tyr Ser Ser Gln Thr Thr Ala Ile
         275                 280                 285            
 Leu Gly Ala Leu Leu Gly Ser Cys Cys Pro Gln Leu Gln Val Leu Glu
     290                 295                 300                
 Val Ser Thr Gly Ile Asn Arg Asn Ser Ile Pro Leu Gln Leu Pro Val
 305                 310                 315                 320
 Glu Ala Leu Gln Lys Gly Cys Pro Gln Leu Gln Val Leu Arg Leu Leu
                 325                 330                 335    
 Asn Leu Met Trp Leu Pro Lys Pro Pro Gly Arg Gly Val Ala Pro Gly
             340                 345                 350        
 Pro Gly Phe Pro Ser Leu Glu Glu Leu Cys Leu Ala Ser Ser Thr Cys
         355                 360                 365            
 Asn Phe Val Ser Asn Glu Val Leu Gly Arg Leu Leu His Gly Ser Pro
     370                 375                 380                
 Asn Leu Arg Leu Leu Asp Leu Arg Gly Cys Ala Arg Ile Thr Pro Ala
 385                 390                 395                 400
 Gly Leu Gln Asp Leu Pro Cys Arg Glu Leu Glu Gln Leu His Leu Gly
                 405                 410                 415    
 Leu Tyr Gly Thr Ser Asp Arg Leu Thr Leu Ala Lys Glu Gly Ser Pro
             420                 425                 430        
 Phe Leu Thr Gln Lys Trp Cys His Thr Leu Arg Glu Leu Asp Leu Ser
         435                 440                 445            
 Gly Gln Gly Phe Ser Glu Lys Asp Leu Glu Gln Ala Leu Ala Ala Phe
     450                 455                 460                
 Leu Ser Thr Pro Gly Gly Ser His Pro Ala Leu Cys Ser Leu Asn Leu
 465                 470                 475                 480
 Arg Gly Thr Arg Val Thr Pro Ser Thr Val Ser Ser Val Ile Ser Ser
                 485                 490                 495    
 Cys Pro Gly Leu Leu Tyr Leu Asn Leu Glu Ser Cys Arg Cys Leu Pro
             500                 505                 510        
 Arg Gly Leu Lys Arg Ala Tyr Arg Gly Leu Glu Glu Val Gln Trp Cys
         515                 520                 525            
 Leu Glu Gln Leu Leu Thr Ser Pro Ser Pro Ser
     530                 535                



      <210> 394
      <211> 239
      <212> PRT
      <213> Homo sapiens


      <400> 394
 Met Gly Asn Ser Ala Leu Arg Ala His Val Glu Thr Ala Gln Lys Thr
   1               5                  10                  15    
 Gly Val Phe Gln Leu Lys Asp Arg Gly Leu Thr Glu Phe Pro Ala Asp
              20                  25                  30        
 Leu Gln Lys Leu Thr Ser Asn Leu Arg Thr Ile Asp Leu Ser Asn Asn
          35                  40                  45            
 Lys Ile Glu Ser Leu Pro Pro Leu Leu Ile Gly Lys Phe Thr Leu Leu
      50                  55                  60                
 Lys Ser Leu Ser Leu Asn Asn Asn Lys Leu Thr Val Leu Pro Asp Glu
  65                  70                  75                  80
 Ile Cys Asn Leu Lys Lys Leu Glu Thr Leu Ser Leu Asn Asn Asn His
                  85                  90                  95    
 Leu Arg Glu Leu Pro Ser Thr Phe Gly Gln Leu Ser Ala Leu Lys Thr
             100                 105                 110        
 Leu Ser Leu Ser Gly Asn Gln Leu Gly Ala Leu Pro Pro Gln Leu Cys
         115                 120                 125            
 Ser Leu Arg His Leu Asp Val Met Asp Leu Ser Lys Asn Gln Ile Arg
     130                 135                 140                
 Ser Ile Pro Asp Ser Val Gly Glu Leu Gln Val Ile Glu Leu Asn Leu
 145                 150                 155                 160
 Asn Gln Asn Gln Ile Ser Gln Ile Ser Val Lys Ile Ser Cys Cys Pro
                 165                 170                 175    
 Arg Leu Lys Ile Leu Arg Leu Glu Glu Asn Cys Leu Glu Leu Ser Met
             180                 185                 190        
 Leu Pro Gln Ser Ile Leu Ser Asp Ser Gln Ile Cys Leu Leu Ala Val
         195                 200                 205            
 Glu Gly Asn Leu Phe Glu Ile Lys Lys Leu Arg Glu Leu Glu Gly Tyr
     210                 215                 220                
 Asp Lys Tyr Met Glu Arg Phe Thr Ala Thr Lys Lys Lys Phe Ala
 225                 230                 235                



      <210> 395
      <211> 181
      <212> PRT
      <213> Homo sapiens


      <400> 395
 Met Leu Gly Arg Arg Cys Cys Val His Val Arg Lys His Leu Ile Ala
   1               5                  10                  15    
 Cys Gln Lys Phe Pro Pro Leu Cys Ala Cys Gln Val Phe Asp Gln Val
              20                  25                  30        
 Arg Thr Leu Val Leu Cys Glu Cys Ala His Ala Asp Arg Ser Gly Gly
          35                  40                  45            
 Ala Pro Ser Leu Cys Pro His Ala Ala Glu Pro Arg Gly Ser Pro Ala
      50                  55                  60                
 Pro Gln Ala Cys Gly Ser Ala Ala Lys Cys Val Arg Cys Ala Ser Trp
  65                  70                  75                  80
 Val Leu Leu Cys Ala Leu Ser Tyr Gly Asp Thr Gly Gly Val Gly Leu
                  85                  90                  95    
 Asp Arg Tyr Arg Ser Tyr Tyr Gly Asp Thr Gly Gly Val Arg Leu Asp
             100                 105                 110        
 Arg Tyr Arg Ser Asp Tyr Gly Gly Thr Gly Gly Val Gly Leu Asp Arg
         115                 120                 125            
 Tyr Arg Ser Asp Tyr Gly Asp Thr Gly Gly Val Gly Leu Asp Arg Tyr
     130                 135                 140                
 Arg Ser Asp Tyr Gly Gly Thr Gly Cys Val Gly Leu Asp Arg Tyr Arg
 145                 150                 155                 160
 Ser Asp Tyr Gly Gly Thr Gly Gly Val Gly Leu Asp Arg Tyr Trp Ser
                 165                 170                 175    
 Asp Ala Arg Ala Pro
             180    



      <210> 396
      <211> 617
      <212> PRT
      <213> Homo sapiens


      <400> 396
 Met Trp Lys Val Lys Glu Pro His Tyr His Leu Phe Phe Phe Ala Phe
   1               5                  10                  15    
 Ser Tyr Cys Trp Ser Trp Glu Pro Phe Pro Ser Glu Gln Gln Pro Cys
              20                  25                  30        
 Pro Ala Ser Val Leu Ser Ser Gln Gln Gly Lys Ser Ile Ser Leu Ile
          35                  40                  45            
 Met Glu Glu Asn Asn Asp Ser Thr Glu Asn Pro Gln Gln Gly Gln Gly
      50                  55                  60                
 Arg Gln Asn Ala Ile Lys Cys Gly Trp Leu Arg Lys Gln Gly Gly Phe
  65                  70                  75                  80
 Val Lys Thr Trp His Thr Arg Trp Phe Val Leu Lys Gly Asp Gln Leu
                  85                  90                  95    
 Tyr Tyr Phe Lys Asp Glu Asp Glu Thr Lys Pro Leu Gly Thr Ile Phe
             100                 105                 110        
 Leu Pro Gly Asn Lys Val Ser Glu His Pro Cys Asn Glu Glu Asn Pro
         115                 120                 125            
 Gly Lys Phe Leu Phe Glu Val Val Pro Gly Gly Asp Arg Asp Arg Met
     130                 135                 140                
 Thr Ala Asn His Glu Ser Tyr Leu Leu Met Ala Ser Thr Gln Asn Asp
 145                 150                 155                 160
 Met Glu Asp Trp Val Lys Ser Ile Arg Arg Val Ile Trp Gly Pro Phe
                 165                 170                 175    
 Gly Gly Gly Thr Val Val Val Gln Gln Leu Met Ser Val Met Ile Ser
             180                 185                 190        
 Lys His Asp Cys Leu Phe Pro Lys Asp Ala Glu Leu Gln Ser Lys Pro
         195                 200                 205            
 Gln Asp Gly Val Ser Asn Asn Asn Glu Ile Gln Lys Lys Ala Thr Met
     210                 215                 220                
 Gly Gln Leu Gln Asn Lys Glu Asn Asn Asn Thr Lys Asp Ser Pro Ser
 225                 230                 235                 240
 Arg Gln Cys Ser Trp Asp Lys Ser Glu Ser Pro Gln Arg Ser Ser Met
                 245                 250                 255    
 Asn Asn Gly Ser Pro Thr Ala Leu Ser Gly Ser Lys Thr Asn Ser Pro
             260                 265                 270        
 Lys Asn Ser Val His Lys Leu Asp Val Ser Arg Ser Pro Pro Leu Met
         275                 280                 285            
 Val Lys Lys Asn Pro Ala Phe Asn Lys Gly Ser Gly Ile Val Thr Asn
     290                 295                 300                
 Gly Ser Phe Ser Ser Ser Asn Ala Glu Gly Leu Glu Lys Thr Gln Thr
 305                 310                 315                 320
 Thr Pro Asn Gly Ser Leu Gln Ala Arg Arg Ser Ser Ser Leu Lys Val
                 325                 330                 335    
 Ser Gly Thr Lys Met Gly Thr His Ser Val Gln Asn Gly Thr Val Arg
             340                 345                 350        
 Met Gly Ile Leu Asn Ser Asp Thr Leu Gly Asn Pro Thr Asn Val Arg
         355                 360                 365            
 Asn Met Ser Trp Leu Pro Asn Gly Tyr Val Thr Leu Arg Asp Asn Lys
     370                 375                 380                
 Gln Lys Glu Gln Ala Gly Glu Leu Gly Gln His Asn Arg Leu Ser Thr
 385                 390                 395                 400
 Tyr Asp Asn Val His Gln Gln Phe Ser Met Met Asn Leu Asp Asp Lys
                 405                 410                 415    
 Gln Ser Ile Asp Ser Ala Thr Trp Ser Thr Ser Ser Cys Glu Ile Ser
             420                 425                 430        
 Leu Pro Glu Asn Ser Asn Ser Cys Arg Ser Ser Thr Thr Thr Cys Pro
         435                 440                 445            
 Glu Gln Asp Phe Phe Gly Gly Asn Phe Glu Asp Pro Val Leu Asp Gly
     450                 455                 460                
 Pro Pro Gln Asp Asp Leu Ser His Pro Arg Asp Tyr Glu Ser Lys Ser
 465                 470                 475                 480
 Asp His Arg Ser Val Gly Gly Arg Ser Ser Arg Ala Thr Ser Ser Ser
                 485                 490                 495    
 Asp Asn Ser Glu Thr Phe Val Gly Asn Ser Ser Ser Asn His Ser Ala
             500                 505                 510        
 Leu His Ser Leu Val Ser Ser Leu Lys Gln Glu Met Thr Lys Gln Lys
         515                 520                 525            
 Ile Glu Tyr Glu Ser Arg Ile Lys Ser Leu Glu Gln Arg Asn Leu Thr
     530                 535                 540                
 Leu Glu Thr Glu Met Met Ser Leu His Asp Glu Leu Asp Gln Glu Arg
 545                 550                 555                 560
 Lys Lys Phe Thr Met Ile Glu Ile Lys Met Arg Asn Ala Glu Arg Ala
                 565                 570                 575    
 Lys Glu Asp Ala Glu Lys Arg Asn Asp Met Leu Gln Lys Glu Met Glu
             580                 585                 590        
 Gln Phe Phe Ser Thr Phe Gly Glu Leu Thr Val Glu Pro Arg Arg Thr
         595                 600                 605            
 Glu Arg Gly Asn Thr Ile Trp Ile Gln
     610                 615        



      <210> 397
      <211> 401
      <212> PRT
      <213> Homo sapiens


      <400> 397
 Met Lys Glu Asn Phe Lys His Arg His Val Val Ala Phe Ile Ser Ser
   1               5                  10                  15    
 Gln Glu Ala Gln Glu Asp Ser Arg Glu Glu Glu Asp Arg Leu Glu Ser
              20                  25                  30        
 Arg Phe Tyr Phe Leu Phe Leu Leu Glu Leu Ser Tyr Lys Thr Thr Gly
          35                  40                  45            
 Leu Asn Arg Glu Pro Thr Val Ser Leu Asn Ser Lys Ser Gly Thr Pro
      50                  55                  60                
 Met Asp Gln Asn Glu His Ser His Trp Gly Pro His Ala Lys Gly Gln
  65                  70                  75                  80
 Cys Ala Ser Arg Ser Glu Leu Arg Ile Ile Leu Val Gly Lys Thr Gly
                  85                  90                  95    
 Thr Gly Lys Ser Ala Ala Gly Asn Ser Ile Leu Arg Lys Gln Ala Phe
             100                 105                 110        
 Glu Ser Lys Leu Gly Ser Gln Thr Leu Thr Lys Thr Cys Ser Lys Ser
         115                 120                 125            
 Gln Gly Ser Trp Gly Asn Arg Glu Ile Val Ile Ile Asp Thr Pro Asp
     130                 135                 140                
 Met Phe Ser Trp Lys Asp His Cys Glu Ala Leu Tyr Lys Glu Val Gln
 145                 150                 155                 160
 Arg Cys Tyr Leu Leu Ser Ala Pro Gly Pro His Val Leu Leu Leu Val
                 165                 170                 175    
 Thr Gln Leu Gly Arg Tyr Thr Ser Gln Asp Gln Gln Ala Ala Gln Arg
             180                 185                 190        
 Val Lys Glu Ile Phe Gly Glu Asp Ala Met Gly His Thr Ile Val Leu
         195                 200                 205            
 Phe Thr His Lys Glu Asp Leu Asn Gly Gly Ser Leu Met Asp Tyr Met
     210                 215                 220                
 His Asp Ser Asp Asn Lys Ala Leu Ser Lys Leu Val Ala Ala Cys Gly
 225                 230                 235                 240
 Gly Arg Ile Cys Ala Phe Asn Asn Arg Ala Glu Gly Ser Asn Gln Asp
                 245                 250                 255    
 Asp Gln Val Lys Glu Leu Met Asp Cys Ile Glu Asp Leu Leu Met Glu
             260                 265                 270        
 Lys Asn Gly Asp His Tyr Thr Asn Gly Leu Tyr Ser Leu Ile Gln Arg
         275                 280                 285            
 Ser Lys Cys Gly Pro Val Gly Ser Asp Glu Arg Val Lys Glu Phe Lys
     290                 295                 300                
 Gln Ser Leu Ile Lys Tyr Met Glu Thr Gln Arg Ser Tyr Thr Ala Leu
 305                 310                 315                 320
 Ala Glu Ala Asn Cys Leu Lys Gly Ala Leu Ile Lys Thr Gln Leu Cys
                 325                 330                 335    
 Val Leu Phe Cys Ile Gln Leu Phe Leu Arg Leu Ile Ile Leu Trp Leu
             340                 345                 350        
 Cys Ile Leu His Ser Met Cys Asn Leu Phe Cys Cys Leu Leu Phe Ser
         355                 360                 365            
 Met Cys Asn Leu Phe Cys Ser Leu Leu Phe Ile Ile Pro Lys Lys Leu
     370                 375                 380                
 Met Ile Phe Leu Arg Thr Val Ile Arg Leu Glu Arg Lys Thr Pro Arg
 385                 390                 395                 400
 Leu
    



      <210> 398
      <211> 581
      <212> PRT
      <213> Homo sapiens


      <400> 398
 Met Trp Gly Arg Thr Ala Arg Arg Arg Cys Pro Arg Glu Leu Arg Arg
   1               5                  10                  15    
 Gly Arg Glu Ala Leu Leu Val Leu Leu Ala Leu Leu Ala Leu Ala Gly
              20                  25                  30        
 Leu Gly Ser Val Leu Arg Ala Gln Arg Gly Ala Gly Ala Gly Ala Ala
          35                  40                  45            
 Glu Pro Gly Pro Pro Arg Thr Pro Arg Pro Gly Arg Arg Glu Pro Val
      50                  55                  60                
 Met Pro Arg Pro Pro Val Pro Ala Asn Ala Leu Gly Ala Arg Gly Glu
  65                  70                  75                  80
 Ala Val Arg Leu Gln Leu Gln Gly Glu Glu Leu Arg Leu Gln Glu Glu
                  85                  90                  95    
 Ser Val Arg Leu His Gln Ile Asn Ile Tyr Leu Ser Asp Arg Ile Ser
             100                 105                 110        
 Leu His Arg Arg Leu Pro Glu Arg Trp Asn Pro Leu Cys Lys Glu Lys
         115                 120                 125            
 Lys Tyr Asp Tyr Asp Asn Leu Pro Arg Thr Ser Val Ile Ile Ala Phe
     130                 135                 140                
 Tyr Asn Glu Ala Trp Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Leu
 145                 150                 155                 160
 Glu Thr Ser Pro Asp Ile Leu Leu Glu Glu Val Ile Leu Val Asp Asp
                 165                 170                 175    
 Tyr Ser Asp Arg Glu His Leu Lys Glu Arg Leu Ala Asn Glu Leu Ser
             180                 185                 190        
 Gly Leu Pro Lys Val Arg Leu Ile Arg Ala Asn Lys Arg Glu Gly Leu
         195                 200                 205            
 Val Arg Ala Arg Leu Leu Gly Ala Ser Ala Ala Arg Gly Asp Val Leu
     210                 215                 220                
 Thr Phe Leu Asp Cys His Cys Glu Cys His Glu Gly Trp Leu Glu Pro
 225                 230                 235                 240
 Leu Leu Gln Arg Ile His Glu Glu Glu Ser Ala Val Val Cys Pro Val
                 245                 250                 255    
 Ile Asp Val Ile Asp Trp Asn Thr Phe Glu Tyr Leu Gly Asn Ser Gly
             260                 265                 270        
 Glu Pro Gln Ile Gly Gly Phe Asp Trp Arg Leu Val Phe Thr Trp His
         275                 280                 285            
 Thr Val Pro Glu Arg Glu Arg Ile Arg Met Gln Ser Pro Val Asp Val
     290                 295                 300                
 Ile Arg Ser Pro Thr Met Ala Gly Gly Leu Phe Ala Val Ser Lys Lys
 305                 310                 315                 320
 Tyr Phe Glu Tyr Leu Gly Ser Tyr Asp Thr Gly Met Glu Val Trp Gly
                 325                 330                 335    
 Gly Glu Asn Leu Glu Phe Ser Phe Arg Ile Trp Gln Cys Gly Gly Val
             340                 345                 350        
 Leu Glu Thr His Pro Cys Ser His Val Gly His Val Phe Pro Lys Gln
         355                 360                 365            
 Ala Pro Tyr Ser Arg Asn Lys Ala Leu Ala Asn Ser Val Arg Ala Ala
     370                 375                 380                
 Glu Val Trp Met Asp Glu Phe Lys Glu Leu Tyr Tyr His Arg Asn Pro
 385                 390                 395                 400
 Arg Ala Arg Leu Glu Pro Phe Gly Asp Val Thr Glu Arg Lys Gln Leu
                 405                 410                 415    
 Arg Asp Lys Leu Gln Cys Lys Asp Phe Lys Trp Phe Leu Glu Thr Val
             420                 425                 430        
 Tyr Pro Glu Leu His Val Pro Glu Asp Arg Pro Gly Phe Phe Gly Met
         435                 440                 445            
 Leu Gln Asn Lys Gly Leu Thr Asp Tyr Cys Phe Asp Tyr Asn Pro Pro
     450                 455                 460                
 Asp Glu Asn Gln Ile Val Gly His Gln Val Ile Leu Tyr Leu Cys His
 465                 470                 475                 480
 Gly Met Gly Gln Asn Gln Phe Phe Glu Tyr Thr Ser Gln Lys Glu Ile
                 485                 490                 495    
 Arg Tyr Asn Thr His Gln Pro Glu Gly Cys Ile Ala Val Glu Ala Gly
             500                 505                 510        
 Met Asp Thr Leu Ile Met His Leu Cys Glu Glu Thr Ala Pro Glu Asn
         515                 520                 525            
 Gln Lys Phe Ile Leu Gln Glu Asp Gly Ser Leu Phe His Glu Gln Ser
     530                 535                 540                
 Lys Lys Cys Val Gln Ala Ala Arg Lys Glu Ser Ser Asp Ser Phe Val
 545                 550                 555                 560
 Pro Leu Leu Arg Asp Cys Thr Asn Ser Asp His Gln Lys Trp Phe Phe
                 565                 570                 575    
 Lys Glu Arg Met Leu
             580    



      <210> 399
      <211> 167
      <212> PRT
      <213> Homo sapiens


      <400> 399
 Met Gly Val Lys Arg Ser Leu Gln Ser Gly Gly Ile Leu Leu Ser Leu
   1               5                  10                  15    
 Val Ala Asn Val Leu Met Val Leu Ser Thr Ala Thr Asn Tyr Trp Thr
              20                  25                  30        
 Arg Gln Gln Glu Gly His Ser Gly Leu Trp Gln Glu Cys Asn His Gly
          35                  40                  45            
 Ile Cys Ser Ser Ile Pro Cys Gln Thr Thr Leu Ala Val Thr Val Ala
      50                  55                  60                
 Cys Met Val Leu Ala Val Gly Val Gly Val Val Gly Met Val Met Gly
  65                  70                  75                  80
 Leu Arg Ile Arg Cys Asp Glu Gly Glu Ser Leu Arg Gly Gln Thr Thr
                  85                  90                  95    
 Ser Ala Phe Leu Phe Leu Gly Gly Leu Leu Leu Leu Thr Ala Leu Ile
             100                 105                 110        
 Gly Tyr Thr Val Lys Asn Ala Trp Lys Asn Asn Val Phe Phe Ser Trp
         115                 120                 125            
 Ser Tyr Phe Ser Gly Trp Leu Ala Leu Pro Phe Ser Ile Leu Ala Gly
     130                 135                 140                
 Phe Cys Phe Leu Leu Ala Asp Met Ile Met Gln Ser Thr Asp Ala Ile
 145                 150                 155                 160
 Ser Gly Phe Pro Val Cys Leu
                 165        



      <210> 400
      <211> 684
      <212> PRT
      <213> Homo sapiens


      <400> 400
 Met Trp Val Leu Leu Arg Ser Gly Tyr Pro Leu Arg Ile Leu Leu Pro
   1               5                  10                  15    
 Leu Arg Gly Glu Trp Met Gly Arg Arg Gly Leu Pro Arg Asn Leu Ala
              20                  25                  30        
 Pro Gly Pro Pro Arg Arg Arg Tyr Arg Lys Glu Thr Leu Gln Ala Leu
          35                  40                  45            
 Asp Met Pro Val Leu Pro Val Thr Ala Thr Glu Ile Arg Gln Tyr Leu
      50                  55                  60                
 Arg Gly His Gly Ile Pro Phe Gln Asp Gly His Ser Cys Leu Arg Ala
  65                  70                  75                  80
 Leu Ser Pro Phe Ala Glu Ser Ser Gln Leu Lys Gly Gln Thr Gly Val
                  85                  90                  95    
 Thr Thr Ser Phe Ser Leu Phe Ile Asp Lys Thr Thr Gly His Phe Leu
             100                 105                 110        
 Cys Met Thr Ser Leu Ala Glu Gly Ser Trp Glu Asp Phe Gln Ala Ser
         115                 120                 125            
 Val Glu Gly Arg Gly Asp Gly Ala Arg Glu Gly Phe Leu Leu Ser Lys
     130                 135                 140                
 Ala Pro Glu Phe Glu Asp Ser Glu Glu Val Arg Arg Ile Trp Asn Arg
 145                 150                 155                 160
 Ala Ile Pro Leu Trp Glu Leu Pro Asp Gln Glu Glu Val Gln Leu Ala
                 165                 170                 175    
 Asp Thr Met Phe Gly Leu Thr Lys Val Thr Asp Asp Thr Leu Lys Arg
             180                 185                 190        
 Phe Ser Val Arg Tyr Leu Arg Pro Ala Arg Ser Leu Val Phe Pro Trp
         195                 200                 205            
 Phe Ser Pro Gly Gly Ser Gly Leu Arg Gly Leu Lys Leu Leu Glu Ala
     210                 215                 220                
 Lys Cys Gln Gly Asp Gly Val Ser Tyr Glu Glu Thr Thr Ile Pro Arg
 225                 230                 235                 240
 Pro Ser Ala Tyr His Asn Leu Phe Gly Leu Pro Leu Ile Ser Arg Arg
                 245                 250                 255    
 Asp Ala Glu Val Val Leu Thr Ser Arg Glu Leu Asp Ser Leu Ala Leu
             260                 265                 270        
 Asn Gln Ser Thr Gly Leu Pro Thr Leu Thr Leu Pro Arg Gly Thr Thr
         275                 280                 285            
 Cys Leu Pro Pro Ala Leu Leu Pro Tyr Leu Glu Gln Phe Arg Arg Ile
     290                 295                 300                
 Val Phe Trp Leu Gly Asp Asp Leu Arg Ser Trp Glu Ala Ala Lys Leu
 305                 310                 315                 320
 Phe Ala Arg Lys Leu Asn Pro Lys Arg Cys Phe Leu Val Arg Pro Gly
                 325                 330                 335    
 Asp Gln Gln Pro Arg Pro Leu Glu Ala Leu Asn Gly Gly Phe Asn Leu
             340                 345                 350        
 Ser Arg Ile Leu Arg Thr Ala Leu Pro Ala Trp His Lys Ser Ile Val
         355                 360                 365            
 Ser Phe Arg Gln Leu Arg Glu Glu Val Leu Gly Glu Leu Ser Asn Val
     370                 375                 380                
 Glu Gln Ala Ala Gly Leu Arg Trp Ser Arg Phe Pro Asp Leu Asn Arg
 385                 390                 395                 400
 Ile Leu Lys Gly His Arg Lys Gly Glu Leu Thr Val Phe Thr Gly Pro
                 405                 410                 415    
 Thr Gly Ser Gly Lys Thr Thr Phe Ile Ser Glu Tyr Ala Leu Asp Leu
             420                 425                 430        
 Cys Ser Gln Gly Val Asn Thr Leu Trp Gly Ser Phe Glu Ile Ser Asn
         435                 440                 445            
 Val Arg Leu Ala Arg Val Met Leu Thr Gln Phe Ala Glu Gly Arg Leu
     450                 455                 460                
 Glu Asp Gln Leu Asp Lys Tyr Asp His Trp Ala Asp Arg Phe Glu Asp
 465                 470                 475                 480
 Leu Pro Leu Tyr Phe Met Thr Phe His Gly Gln Gln Ser Ile Arg Thr
                 485                 490                 495    
 Val Ile Asp Thr Met Gln His Ala Val Tyr Val Tyr Asp Ile Cys His
             500                 505                 510        
 Val Ile Ile Asp Asn Leu Gln Phe Met Met Gly His Glu Gln Leu Ser
         515                 520                 525            
 Thr Asp Arg Ile Ala Ala Gln Asp Tyr Ile Ile Gly Val Phe Arg Lys
     530                 535                 540                
 Phe Ala Thr Asp Asn Asn Cys His Val Thr Leu Val Ile His Pro Arg
 545                 550                 555                 560
 Lys Glu Asp Asp Asp Lys Glu Leu Gln Thr Ala Ser Ile Phe Gly Ser
                 565                 570                 575    
 Ala Lys Ala Ser Gln Glu Ala Asp Asn Val Leu Ile Leu Gln Asp Arg
             580                 585                 590        
 Lys Leu Val Thr Gly Pro Gly Lys Arg Tyr Leu Gln Val Ser Lys Asn
         595                 600                 605            
 Arg Phe Asp Gly Asp Val Gly Val Phe Pro Leu Glu Phe Asn Lys Asn
     610                 615                 620                
 Ser Leu Thr Phe Ser Ile Pro Pro Lys Asn Lys Ala Arg Leu Lys Lys
 625                 630                 635                 640
 Ile Lys Asp Asp Thr Gly Pro Val Ala Lys Lys Pro Ser Ser Gly Lys
                 645                 650                 655    
 Lys Gly Ala Thr Thr Gln Asn Ser Glu Ile Cys Ser Gly Gln Ala Pro
             660                 665                 670        
 Thr Pro Asp Gln Pro Asp Thr Ser Lys Arg Ser Lys
         675                 680                



      <210> 401
      <211> 485
      <212> PRT
      <213> Homo sapiens


      <400> 401
 Met Ala Glu Gly Thr Ala Glu Ala Pro Leu Glu Asn Gly Gly Gly Gly
   1               5                  10                  15    
 Asp Ser Gly Ala Gly Ala Leu Glu Arg Gly Val Ala Pro Ile Lys Arg
              20                  25                  30        
 Gln Tyr Leu Thr Thr Lys Glu Gln Phe His Gln Phe Leu Glu Ala Lys
          35                  40                  45            
 Gly Gln Glu Lys Thr Cys Arg Glu Thr Glu Val Gly Asp Pro Ala Gly
      50                  55                  60                
 Asn Glu Leu Ala Glu Pro Glu Ala Lys Arg Ile Arg Leu Glu Asp Gly
  65                  70                  75                  80
 Gln Thr Ala Asp Gly Gln Thr Glu Glu Ala Ala Glu Pro Gly Glu Gln
                  85                  90                  95    
 Leu Gln Thr Gln Lys Arg Ala Arg Gly Gln Asn Lys Gly Arg Pro His
             100                 105                 110        
 Val Lys Pro Thr Asn Tyr Asp Lys Asn Arg Leu Cys Pro Ser Leu Ile
         115                 120                 125            
 Gln Glu Ser Ala Ala Lys Cys Phe Phe Gly Asp Arg Cys Arg Phe Leu
     130                 135                 140                
 His Asp Val Gly Arg Tyr Leu Glu Thr Lys Pro Ala Asp Leu Gly Pro
 145                 150                 155                 160
 Arg Cys Val Leu Phe Glu Thr Phe Gly Arg Cys Pro Tyr Gly Val Thr
                 165                 170                 175    
 Cys Arg Phe Ala Gly Ala His Leu Arg Pro Glu Gly Gln Asn Leu Glu
             180                 185                 190        
 Gln Glu Glu Leu Ala Ala Arg Gly Thr Gln Pro Pro Ser Ile Arg Asn
         195                 200                 205            
 Gly Leu Asp Lys Ala Leu Gln Gln Gln Leu Arg Lys Arg Glu Val Arg
     210                 215                 220                
 Phe Glu Arg Ala Glu Gln Ala Leu Arg Arg Phe Ser Gln Gly Pro Thr
 225                 230                 235                 240
 Pro Ala Ala Ala Val Pro Glu Gly Thr Ala Ala Glu Gly Ala Pro Arg
                 245                 250                 255    
 Gln Glu Asn Cys Gly Ala Gln Gln Val Pro Ala Gly Pro Gly Thr Ser
             260                 265                 270        
 Thr Pro Pro Ser Ser Pro Val Arg Thr Cys Gly Pro Leu Thr Asp Glu
         275                 280                 285            
 Asp Val Val Arg Leu Arg Pro Cys Glu Lys Lys Arg Leu Asp Ile Arg
     290                 295                 300                
 Gly Lys Leu Tyr Leu Ala Pro Leu Thr Thr Cys Gly Asn Leu Pro Phe
 305                 310                 315                 320
 Arg Arg Ile Cys Lys Arg Phe Gly Ala Asp Val Thr Cys Gly Glu Met
                 325                 330                 335    
 Ala Val Cys Thr Asn Leu Leu Gln Gly Gln Met Ser Glu Trp Ala Leu
             340                 345                 350        
 Leu Lys Arg His Gln Cys Glu Asp Ile Phe Gly Val Gln Leu Glu Gly
         355                 360                 365            
 Ala Phe Pro Asp Thr Met Thr Lys Cys Ala Glu Leu Leu Ser Arg Thr
     370                 375                 380                
 Val Glu Val Asp Phe Val Asp Ile Asn Val Gly Cys Pro Ile Asp Leu
 385                 390                 395                 400
 Val Tyr Lys Lys Gly Gly Gly Cys Ala Leu Met Asn Arg Ser Thr Lys
                 405                 410                 415    
 Phe Gln Gln Ile Val Arg Gly Met Asn Gln Val Leu Asp Val Pro Leu
             420                 425                 430        
 Thr Val Lys Ile Arg Thr Gly Val Gln Glu Arg Val Asn Leu Ala His
         435                 440                 445            
 Arg Leu Leu Pro Glu Leu Arg Asp Trp Gly Val Ala Leu Val Thr Glu
     450                 455                 460                
 Met Gly Thr Ser Cys His Leu Arg Met Pro Thr Ala Pro Cys Arg Leu
 465                 470                 475                 480
 Val Ser Pro Gly Ser
                 485



      <210> 402
      <211> 672
      <212> PRT
      <213> Homo sapiens


      <400> 402
 Met Asp Leu Ile Leu Asn Arg Met Asp Tyr Leu Gln Val Gly Val Thr
   1               5                  10                  15    
 Ser Gln Lys Thr Met Lys Leu Ile Pro Ala Ser Arg His Arg Ala Thr
              20                  25                  30        
 Gln Lys Val Val Ile Gly Asp His Asp Gly Val Val Met Cys Phe Gly
          35                  40                  45            
 Met Lys Lys Gly Glu Ala Ala Ala Val Phe Lys Thr Leu Pro Gly Pro
      50                  55                  60                
 Lys Ile Ala Arg Leu Glu Leu Gly Gly Val Ile Asn Thr Pro Gln Glu
  65                  70                  75                  80
 Lys Ile Phe Ile Ala Ala Ala Ser Glu Ile Arg Gly Phe Thr Lys Arg
                  85                  90                  95    
 Gly Lys Gln Phe Leu Ser Phe Glu Thr Asn Leu Thr Glu Ser Ile Lys
             100                 105                 110        
 Ala Met His Ile Ser Gly Ser Asp Leu Phe Leu Ser Ala Ser Tyr Ile
         115                 120                 125            
 Tyr Asn His Tyr Cys Asp Cys Lys Asp Gln His Tyr Tyr Leu Ser Gly
     130                 135                 140                
 Asp Lys Ile Asn Asp Val Ile Cys Leu Pro Val Glu Arg Leu Ser Arg
 145                 150                 155                 160
 Ile Thr Pro Val Leu Ala Cys Gln Asp Arg Val Leu Arg Val Leu Gln
                 165                 170                 175    
 Gly Ser Asp Val Met Tyr Ala Val Glu Val Pro Gly Pro Pro Thr Val
             180                 185                 190        
 Leu Ala Leu His Asn Gly Asn Gly Gly Asp Ser Gly Glu Asp Leu Leu
         195                 200                 205            
 Phe Gly Thr Ser Asp Gly Lys Leu Ala Leu Ile Gln Ile Thr Thr Ser
     210                 215                 220                
 Lys Pro Val Arg Lys Trp Glu Ile Gln Asn Glu Lys Lys Arg Gly Gly
 225                 230                 235                 240
 Ile Leu Cys Ile Asp Ser Phe Asp Ile Val Gly Asp Gly Val Lys Asp
                 245                 250                 255    
 Leu Leu Val Gly Arg Asp Asp Gly Met Val Glu Val Tyr Ser Phe Asp
             260                 265                 270        
 Asn Ala Asn Glu Pro Val Leu Arg Phe Asp Gln Met Leu Ser Glu Ser
         275                 280                 285            
 Val Thr Ser Ile Gln Gly Gly Cys Val Gly Lys Asp Ser Tyr Asp Glu
     290                 295                 300                
 Ile Val Val Ser Thr Tyr Ser Gly Trp Val Thr Gly Leu Thr Thr Glu
 305                 310                 315                 320
 Pro Ile His Lys Glu Ser Gly Pro Gly Glu Glu Leu Lys Ile Asn Gln
                 325                 330                 335    
 Glu Met Gln Asn Lys Ile Ser Ser Leu Arg Asn Glu Leu Glu His Leu
             340                 345                 350        
 Gln Tyr Lys Val Leu Gln Glu Arg Glu Asn Tyr Gln Gln Ser Ser Gln
         355                 360                 365            
 Ser Ser Lys Ala Lys Ser Ala Val Pro Ser Phe Gly Ile Asn Asp Lys
     370                 375                 380                
 Phe Thr Leu Asn Lys Asp Asp Ala Ser Tyr Ser Leu Ile Leu Glu Val
 385                 390                 395                 400
 Gln Thr Ala Ile Asp Asn Val Leu Ile Gln Ser Asp Val Pro Ile Asp
                 405                 410                 415    
 Leu Leu Asp Val Asp Lys Asn Ser Ala Val Val Ser Phe Ser Ser Cys
             420                 425                 430        
 Asp Ser Glu Ser Asn Asp Asn Phe Leu Leu Ala Thr Tyr Arg Cys Gln
         435                 440                 445            
 Ala Asp Thr Thr Arg Leu Glu Leu Lys Ile Arg Ser Ile Glu Gly Gln
     450                 455                 460                
 Tyr Gly Thr Leu Gln Ala Tyr Val Thr Pro Arg Ile Gln Pro Lys Thr
 465                 470                 475                 480
 Cys Gln Val Arg Gln Tyr His Ile Lys Pro Leu Ser Leu His Gln Arg
                 485                 490                 495    
 Thr His Phe Ile Asp His Asp Arg Pro Met Asn Thr Leu Thr Leu Thr
             500                 505                 510        
 Gly Gln Phe Ser Phe Ala Glu Val His Ser Trp Val Val Phe Cys Leu
         515                 520                 525            
 Pro Glu Val Pro Glu Lys Pro Pro Ala Gly Glu Cys Val Thr Phe Tyr
     530                 535                 540                
 Phe Gln Asn Thr Phe Leu Asp Thr Gln Leu Glu Ser Thr Tyr Arg Lys
 545                 550                 555                 560
 Gly Glu Gly Val Phe Lys Ser Asp Asn Ile Ser Thr Ile Ser Ile Leu
                 565                 570                 575    
 Lys Asp Val Leu Ser Lys Glu Ala Thr Lys Arg Lys Ile Asn Leu Asn
             580                 585                 590        
 Ile Ser Tyr Glu Ile Asn Glu Val Ser Val Lys His Thr Leu Lys Leu
         595                 600                 605            
 Ile His Pro Lys Leu Glu Tyr Gln Leu Leu Leu Ala Lys Lys Val Gln
     610                 615                 620                
 Leu Ile Asp Ala Leu Lys Glu Leu Gln Ile His Glu Gly Asn Thr Asn
 625                 630                 635                 640
 Phe Leu Ile Pro Glu Tyr His Cys Ile Leu Glu Glu Ala Asp His Leu
                 645                 650                 655    
 Gln Glu Glu Tyr Lys Lys Gln Pro Ala His Leu Glu Arg Leu Tyr Gly
             660                 665                 670        





      <210> 403
      <211> 215
      <212> PRT
      <213> Homo sapiens


      <400> 403
 Met Gly Leu Glu Lys Pro Gln Ser Lys Leu Glu Gly Gly Met His Pro
   1               5                  10                  15    
 Gln Leu Ile Pro Ser Val Ile Ala Val Val Phe Ile Leu Leu Leu Gly
              20                  25                  30        
 Val Cys Phe Ile Ala Ser Cys Leu Val Thr His His Asn Phe Ser Arg
          35                  40                  45            
 Cys Lys Arg Gly Thr Gly Val His Lys Leu Glu His His Ala Lys Leu
      50                  55                  60                
 Lys Cys Ile Lys Glu Lys Ser Glu Leu Lys Ser Ala Glu Gly Ser Thr
  65                  70                  75                  80
 Trp Asn Cys Cys Pro Ile Asp Trp Arg Ala Phe Gln Ser Asn Cys Tyr
                  85                  90                  95    
 Phe Pro Leu Thr Asp Asn Lys Thr Trp Ala Glu Ser Glu Arg Asn Cys
             100                 105                 110        
 Ser Gly Met Gly Ala His Leu Met Thr Ile Ser Thr Glu Ala Glu Gln
         115                 120                 125            
 Asn Phe Ile Ile Gln Phe Leu Asp Arg Arg Leu Ser Tyr Phe Leu Gly
     130                 135                 140                
 Leu Arg Asp Glu Asn Ala Lys Gly Gln Trp Arg Trp Val Asp Gln Thr
 145                 150                 155                 160
 Pro Phe Asn Pro Arg Arg Val Phe Trp His Lys Asn Glu Pro Asp Asn
                 165                 170                 175    
 Ser Gln Gly Glu Asn Cys Val Val Leu Val Tyr Asn Gln Asp Lys Trp
             180                 185                 190        
 Ala Trp Asn Asp Val Pro Cys Asn Phe Glu Ala Ser Arg Ile Cys Lys
         195                 200                 205            
 Ile Pro Gly Thr Thr Leu Asn
     210                 215



      <210> 404
      <211> 71
      <212> PRT
      <213> Homo sapiens


      <400> 404
 Met Cys Ser Tyr Val Ser Ser Met Cys Met Cys Val Cys Ile Tyr Thr
   1               5                  10                  15    
 Tyr Val Cys Thr Gly Ile Tyr Thr Cys Ile Tyr Tyr Leu Tyr Ile His
              20                  25                  30        
 Thr Cys Cys Leu Ile His Val Tyr Ser His Val Tyr Ile His Val Tyr
          35                  40                  45            
 Met Tyr Ile Thr Phe Ile His Ile His Phe Leu Tyr Val Asn Ser Asp
      50                  55                  60                
 Ser Gln Trp Trp His Tyr Lys
  65                  70    



      <210> 405
      <211> 586
      <212> PRT
      <213> Homo sapiens


      <400> 405
 Met Ser Ser Pro Ser Leu Ser Asp Leu Gly Lys Arg Glu Pro Ala Val
   1               5                  10                  15    
 Ala Ala Asp Glu Arg Gly Thr Gln Gln Arg Arg Ala Tyr Ala Asn Ala
              20                  25                  30        
 Thr Trp Asn Ser Ile His Asn Gly Val Ile Ala Val Phe Gln Arg Lys
          35                  40                  45            
 Gly Leu Pro Asp Gln Glu Leu Phe Ser Leu Asn Glu Gly Val Arg Gln
      50                  55                  60                
 Leu Leu Lys Thr Glu Leu Gly Ser Phe Phe Thr Glu Tyr Leu Gln Asn
  65                  70                  75                  80
 Gln Leu Leu Thr Lys Gly Met Val Ile Leu Arg Asp Lys Ile Arg Phe
                  85                  90                  95    
 Tyr Glu Glu Leu Gln Arg Asp Lys Ala Ala Ala Ala Ala Val Leu Gly
             100                 105                 110        
 Ala Val Arg Lys Arg Pro Ser Val Val Pro Met Ala Gly Gln Asp Pro
         115                 120                 125            
 Ala Leu Ser Thr Ser His Pro Phe Tyr Asp Val Ala Arg His Gly Ile
     130                 135                 140                
 Leu Gln Val Ala Gly Asp Asp Arg Phe Gly Arg Arg Val Val Thr Phe
 145                 150                 155                 160
 Ser Cys Cys Arg Met Pro Pro Ser His Glu Leu Asp His Gln Arg Leu
                 165                 170                 175    
 Leu Glu Tyr Leu Lys Tyr Thr Leu Asp Gln Tyr Val Glu Asn Asp Tyr
             180                 185                 190        
 Thr Ile Val Tyr Phe His Tyr Gly Leu Asn Ser Arg Asn Lys Pro Ser
         195                 200                 205            
 Leu Gly Trp Leu Gln Ser Ala Tyr Lys Glu Phe Asp Arg Lys Asp Gly
     210                 215                 220                
 Asp Leu Thr Met Trp Pro Arg Leu Val Ser Asn Ser Lys Leu Lys Arg
 225                 230                 235                 240
 Ser Ser His Leu Ser Leu Pro Lys Tyr Trp Asp Tyr Arg Tyr Lys Lys
                 245                 250                 255    
 Asn Leu Lys Ala Leu Tyr Val Val His Pro Thr Ser Phe Ile Lys Val
             260                 265                 270        
 Leu Trp Asn Ile Leu Lys Pro Leu Ile Ser His Lys Phe Gly Lys Lys
         275                 280                 285            
 Val Ile Tyr Phe Asn Tyr Leu Ser Glu Leu His Glu His Leu Lys Tyr
     290                 295                 300                
 Asp Gln Leu Val Ile Pro Pro Glu Val Leu Arg Tyr Asp Glu Lys Leu
 305                 310                 315                 320
 Gln Ser Leu His Glu Gly Arg Thr Pro Pro Pro Thr Lys Thr Pro Pro
                 325                 330                 335    
 Pro Arg Pro Pro Leu Pro Thr Gln Gln Phe Gly Val Ser Leu Gln Tyr
             340                 345                 350        
 Leu Lys Asp Lys Asn Gln Gly Glu Leu Ile Pro Pro Val Leu Arg Phe
         355                 360                 365            
 Thr Val Thr Tyr Leu Arg Glu Lys Gly Leu Arg Thr Glu Gly Leu Phe
     370                 375                 380                
 Arg Arg Ser Ala Ser Val Gln Thr Val Arg Glu Ile Gln Arg Leu Tyr
 385                 390                 395                 400
 Asn Gln Gly Lys Pro Val Asn Phe Asp Asp Tyr Gly Asp Ile His Ile
                 405                 410                 415    
 Pro Ala Val Ile Leu Lys Thr Phe Leu Arg Glu Leu Pro Gln Pro Leu
             420                 425                 430        
 Leu Thr Phe Gln Ala Tyr Glu Gln Ile Leu Gly Ile Thr Cys Val Glu
         435                 440                 445            
 Ser Ser Leu Arg Val Thr Gly Cys Arg Gln Ile Leu Arg Ser Leu Pro
     450                 455                 460                
 Glu His Asn Tyr Val Val Leu Arg Tyr Leu Met Gly Phe Leu His Ala
 465                 470                 475                 480
 Val Ser Arg Glu Ser Ile Phe Asn Lys Met Asn Ser Ser Asn Leu Ala
                 485                 490                 495    
 Cys Val Phe Gly Leu Asn Leu Ile Trp Pro Ser Gln Gly Val Ser Ser
             500                 505                 510        
 Leu Ser Ala Leu Val Pro Leu Asn Met Phe Thr Glu Leu Leu Ile Glu
         515                 520                 525            
 Tyr Tyr Glu Lys Ile Phe Ser Thr Pro Glu Ala Pro Gly Glu His Gly
     530                 535                 540                
 Leu Ala Pro Trp Glu Gln Gly Ser Arg Ala Ala Pro Leu Gln Glu Ala
 545                 550                 555                 560
 Val Pro Arg Thr Gln Ala Thr Gly Leu Thr Lys Pro Thr Leu Pro Pro
                 565                 570                 575    
 Ser Pro Leu Met Ala Ala Arg Arg Arg Leu
             580                 585    



      <210> 406
      <211> 555
      <212> PRT
      <213> Homo sapiens


      <400> 406
 Met Ser Ser Pro Ser Leu Ser Asp Leu Gly Lys Arg Glu Pro Ala Val
   1               5                  10                  15    
 Ala Ala Asp Glu Arg Gly Thr Gln Gln Arg Arg Ala Tyr Ala Asn Ala
              20                  25                  30        
 Thr Trp Asn Ser Ile His Asn Gly Val Ile Ala Val Phe Gln Arg Lys
          35                  40                  45            
 Gly Leu Pro Asp Gln Glu Leu Phe Ser Leu Asn Glu Gly Val Arg Gln
      50                  55                  60                
 Leu Leu Lys Thr Glu Leu Gly Ser Phe Phe Thr Glu Tyr Leu Gln Asn
  65                  70                  75                  80
 Gln Leu Leu Thr Lys Gly Met Val Ile Leu Arg Asp Lys Ile Arg Phe
                  85                  90                  95    
 Tyr Glu Glu Leu Gln Arg Asp Lys Ala Ala Ala Ala Ala Val Leu Gly
             100                 105                 110        
 Ala Val Arg Lys Arg Pro Ser Val Val Pro Met Ala Gly Gln Asp Pro
         115                 120                 125            
 Ala Leu Ser Thr Ser His Pro Phe Tyr Asp Val Ala Arg His Gly Ile
     130                 135                 140                
 Leu Gln Val Ala Gly Asp Asp Arg Phe Gly Arg Arg Val Val Thr Phe
 145                 150                 155                 160
 Ser Cys Cys Arg Met Pro Pro Ser His Glu Leu Asp His Gln Arg Leu
                 165                 170                 175    
 Leu Glu Tyr Leu Lys Tyr Thr Leu Asp Gln Tyr Val Glu Asn Asp Tyr
             180                 185                 190        
 Thr Ile Val Tyr Phe His Tyr Gly Leu Asn Ser Arg Asn Lys Pro Ser
         195                 200                 205            
 Leu Gly Trp Leu Gln Ser Ala Tyr Lys Glu Phe Asp Arg Lys Tyr Lys
     210                 215                 220                
 Lys Asn Leu Lys Ala Leu Tyr Val Val His Pro Thr Ser Phe Ile Lys
 225                 230                 235                 240
 Val Leu Trp Asn Ile Leu Lys Pro Leu Ile Ser His Lys Phe Gly Lys
                 245                 250                 255    
 Lys Val Ile Tyr Phe Asn Tyr Leu Ser Glu Leu His Glu His Leu Lys
             260                 265                 270        
 Tyr Asp Gln Leu Val Ile Pro Pro Glu Val Leu Arg Tyr Asp Glu Lys
         275                 280                 285            
 Leu Gln Ser Leu His Glu Gly Arg Thr Pro Pro Pro Thr Lys Thr Pro
     290                 295                 300                
 Pro Pro Arg Pro Pro Leu Pro Thr Gln Gln Phe Gly Val Ser Leu Gln
 305                 310                 315                 320
 Tyr Leu Lys Asp Lys Asn Gln Gly Glu Leu Ile Pro Pro Val Leu Arg
                 325                 330                 335    
 Phe Thr Val Thr Tyr Leu Arg Glu Lys Gly Leu Arg Thr Glu Gly Leu
             340                 345                 350        
 Phe Arg Arg Ser Ala Ser Val Gln Thr Val Arg Glu Ile Gln Arg Leu
         355                 360                 365            
 Tyr Asn Gln Gly Lys Pro Val Asn Phe Asp Asp Tyr Gly Asp Ile His
     370                 375                 380                
 Ile Pro Ala Val Ile Leu Lys Thr Phe Leu Arg Glu Leu Pro Gln Pro
 385                 390                 395                 400
 Leu Leu Thr Phe Gln Ala Tyr Glu Gln Ile Leu Gly Ile Thr Cys Val
                 405                 410                 415    
 Glu Ser Ser Leu Arg Val Thr Gly Cys Arg Gln Ile Leu Arg Ser Leu
             420                 425                 430        
 Pro Glu His Asn Tyr Val Val Leu Arg Tyr Leu Met Gly Phe Leu His
         435                 440                 445            
 Ala Val Ser Arg Glu Ser Ile Phe Asn Lys Met Asn Ser Ser Asn Leu
     450                 455                 460                
 Ala Cys Val Phe Gly Leu Asn Leu Ile Trp Pro Ser Gln Gly Val Ser
 465                 470                 475                 480
 Ser Leu Ser Ala Leu Val Pro Leu Asn Met Phe Thr Glu Leu Leu Ile
                 485                 490                 495    
 Glu Tyr Tyr Glu Lys Ile Phe Ser Thr Pro Glu Ala Pro Gly Glu His
             500                 505                 510        
 Gly Leu Ala Pro Trp Glu Gln Gly Ser Arg Ala Ala Pro Leu Gln Glu
         515                 520                 525            
 Ala Val Pro Arg Thr Gln Ala Thr Gly Leu Thr Lys Pro Thr Leu Pro
     530                 535                 540                
 Pro Ser Pro Leu Met Ala Ala Arg Arg Arg Leu
 545                 550                 555



      <210> 407
      <211> 139
      <212> PRT
      <213> Homo sapiens


      <400> 407
 Met Thr His Gly Ser Cys Leu Pro Gln Leu Ser Asp Lys Val Ala Pro
   1               5                  10                  15    
 Ala Lys His Trp Arg Pro Lys Pro Arg Ser Ile Thr Pro Ile Val Thr
              20                  25                  30        
 Pro Pro Ile Ser Ser Ala Ser Ala Val Lys Gly Lys Arg Glu Lys Gly
          35                  40                  45            
 Ser Glu Ala Leu Val Pro Pro His Leu Val Gly Arg Tyr Ala Ser Ser
      50                  55                  60                
 Arg Ser His Pro Ser Gln Gly Gly Glu Gly Arg Pro Gln Ala Gly Cys
  65                  70                  75                  80
 Gly His Ser Trp Leu Thr Leu Ser Ser Ala Thr Asp Arg Leu Ser His
                  85                  90                  95    
 Ser Trp Ala Gly Leu Asn Pro Arg Cys Pro Pro Ala Ala Thr Trp Pro
             100                 105                 110        
 Pro Cys Ser Thr Phe Ser Pro Phe Ala Ser Ser Gly Cys Arg Gln Pro
         115                 120                 125            
 Ser Ser Phe His Lys Asp Val Gln Leu Glu Glu
     130                 135                



      <210> 408
      <211> 121
      <212> PRT
      <213> Homo sapiens


      <400> 408
 Met Lys Lys His Leu Thr Thr Phe Leu Val Ile Leu Trp Leu Tyr Phe
   1               5                  10                  15    
 Tyr Arg Gly Asn Gly Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu
              20                  25                  30        
 Ile Ile Leu Glu Gly Lys Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val
          35                  40                  45            
 Ser Pro Phe Ser Asn Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly
      50                  55                  60                
 Pro Val Ser Leu Thr Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn
  65                  70                  75                  80
 Gly Arg Tyr Thr Ala Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu
                  85                  90                  95    
 His Ile Thr Ala Ser Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val
             100                 105                 110        
 Val Ser Ala Leu Cys Ser Thr Gly Thr
         115                 120    



      <210> 409
      <211> 58
      <212> PRT
      <213> Homo sapiens


      <400> 409
 Met Asp His Thr Gly Ala Ile Asp Thr Glu Asp Glu Val Gly Pro Leu
   1               5                  10                  15    
 Ala His Leu Ala Pro Ser Pro Gln Ser Glu Ala Val Ala His Glu Phe
              20                  25                  30        
 Gln Glu Leu Ser Leu Gln Ser Ser Gln Asn Leu Pro Pro Leu Asn Glu
          35                  40                  45            
 Arg Lys Asn Val Asn Ile Pro Pro Cys Tyr
      50                  55            



      <210> 410
      <211> 88
      <212> PRT
      <213> Homo sapiens


      <400> 410
 Met Thr Leu Gly Ile Thr Ser Phe Ile Ser Phe Tyr Phe Cys Phe Ile
   1               5                  10                  15    
 Ile Tyr Ile Phe Gln Tyr Leu Ile Ile Gly Lys Lys Asn Leu Thr Phe
              20                  25                  30        
 Ser Val Leu Lys Phe Phe Ile Ile Lys Tyr Ile Ser Leu Ile Ile Ile
          35                  40                  45            
 Ser Lys Glu Glu Lys Asn Thr Phe Lys Ile Ser Ile Asp Leu Lys Ile
      50                  55                  60                
 Ile Ile Met Glu Leu Trp Phe Leu Cys Gln Leu Thr Thr His Leu Asp
  65                  70                  75                  80
 Ile Asn Thr Cys Ile Met Lys Ser
                  85            



      <210> 411
      <211> 203
      <212> PRT
      <213> Homo sapiens


      <400> 411
 Met Lys Thr Pro Val Phe Ile Asn Thr Gly Ser Glu Arg Ser Pro Gly
   1               5                  10                  15    
 Arg Cys Ala Asn Pro Ser Gln Glu Val Leu Leu Arg Val Glu Gly Lys
              20                  25                  30        
 Thr Phe Pro Pro Gly Asn Gln Gly Leu Arg Arg Ala Ser Glu Ala Ala
          35                  40                  45            
 Ser Trp Pro Leu Leu Leu Cys Pro Pro Val Pro Pro Ala Arg Ile Asn
      50                  55                  60                
 Val Leu Trp Asn Lys Ser Leu Trp Leu Lys Gln Arg Ala Phe Trp Glu
  65                  70                  75                  80
 Ser Ser Pro Arg Ser Gly Arg Arg Val Pro Gln Lys Glu Leu Arg Gly
                  85                  90                  95    
 Ser Pro Thr Val Ala Pro Leu Asp Ser Thr Ser Phe Met Leu Leu Arg
             100                 105                 110        
 Cys Tyr Pro Gly Ala Gly Pro Gly Arg Pro Gly Gln Ile Ser Pro Ala
         115                 120                 125            
 Pro Gly Cys Gly Gly Leu Glu Gly Cys Leu Ser Arg His Cys Ala Ile
     130                 135                 140                
 Ala Gly Ala Gly Glu Arg Ile Ser Glu Thr Thr Phe Gly Ser Asn Ala
 145                 150                 155                 160
 Leu Tyr His Val His Gln Ile Val Trp Gly Arg Gly Cys Glu Leu Gln
                 165                 170                 175    
 Gln Leu Leu Val Pro Cys Gly Lys Val Gly Gln Gly Gly Gly Cys Pro
             180                 185                 190        
 Pro Pro Leu Pro Pro Val Thr Ser Cys Leu Thr
         195                 200            



      <210> 412
      <211> 314
      <212> PRT
      <213> Homo sapiens


      <400> 412
 Met Gly Cys Arg Cys Cys Lys Ile Ile Gln Ser Tyr Leu Phe Asp Pro
   1               5                  10                  15    
 Val Gln Val Pro Ser Pro Gly Tyr Val Asn Glu Val Asn Ser Cys Lys
              20                  25                  30        
 Leu Asp Glu Asp Asp Thr Asp Lys Leu Lys Gly Lys Trp Ser Ser Glu
          35                  40                  45            
 Val Leu Val Gln Lys Asn Asp Pro Gln Arg Gln Gly Ser Lys Lys Thr
      50                  55                  60                
 Glu Ser Ser Ser Arg Thr Ala Asp Pro Trp Glu Pro Cys Trp Pro His
  65                  70                  75                  80
 Gln Gly Pro Leu Pro Gln Gly Asp Ala Gly Gly Glu His His Ala Cys
                  85                  90                  95    
 Gly Val Asn Gly Ile Gly Pro Ala Ala Thr Pro Gln Pro Thr Gly Asn
             100                 105                 110        
 Ser Ser Pro Thr Gln Asp Asp Arg Gly Ser Trp Ala Ser Thr Ala Asn
         115                 120                 125            
 Thr Val Pro Pro Thr Gln Pro Phe Leu Glu Gly Gly Gly Thr Arg Lys
     130                 135                 140                
 Gln Asp Cys Val Leu Leu Ala Ser Glu Gly Thr Gln Val Met Arg Asn
 145                 150                 155                 160
 Gly Asp Ser Arg Ala Pro Ser Glu Ala Glu Ser Phe Ala Leu Glu Val
                 165                 170                 175    
 Gln Asp His Val Phe Gln Ile Pro Ala Pro Asp Tyr Leu Gln His Trp
             180                 185                 190        
 Gly Pro Ala Gly Asp Asn Val Asp His Asn Glu Lys Asp Cys Val Phe
         195                 200                 205            
 Lys Asn His Thr Glu Asp Glu Ser Leu Glu Gly Ile Gln Pro Pro Val
     210                 215                 220                
 Gly Glu His Gly Leu Asn Thr Pro Phe Ser Val Arg Arg Ser Trp Asp
 225                 230                 235                 240
 Ser Leu Asn Glu Asp Val Glu Thr Glu Val Leu Ser Ile Cys Phe Asn
                 245                 250                 255    
 Glu Lys Gly Pro Val His Ala Met Pro Val Val Asp Ser Gly Asn Arg
             260                 265                 270        
 Gln Glu Asp Thr His Gly Ser Asp Gly Asp Gly Asp Gly Glu Ile Val
         275                 280                 285            
 Asp Glu Asp Ala Ala Val Ala Glu Ala Leu Ala Ala Leu Glu Ala Ala
     290                 295                 300                
 Thr Ala Gly Glu Asp Leu Asp Glu Thr Asp
 305                 310                



      <210> 413
      <211> 439
      <212> PRT
      <213> Homo sapiens


      <400> 413
 Met Leu Thr Gly Val Thr Asp Gly Ile Phe Cys Cys Leu Leu Gly Thr
   1               5                  10                  15    
 Pro Pro Asn Ala Val Gly Pro Leu Glu Ser Val Glu Ser Ser Asp Gly
              20                  25                  30        
 Tyr Thr Phe Val Glu Val Lys Pro Gly Arg Val Leu Arg Val Lys His
          35                  40                  45            
 Ala Gly Pro Ala Pro Ala Ala Ala Pro Pro Pro Pro Ser Ser Ala Ser
      50                  55                  60                
 Ser Asp Ala Ala Gln Gly Asp Leu Ser Gly Leu Val Arg Cys Gln Arg
  65                  70                  75                  80
 Arg Ile Thr Val Tyr Arg Asn Gly Arg Leu Leu Val Glu Asn Leu Gly
                  85                  90                  95    
 Arg Ala Pro Arg Ala Asp Leu Leu His Gly Gln Asn Gly Ser Gly Glu
             100                 105                 110        
 Pro Pro Ala Ala Leu Glu Val Glu Leu Ala Asp Pro Ala Gly Ser Asp
         115                 120                 125            
 Gly Arg Leu Ala Pro Gly Ser Ala Gly Ser Gly Ser Gly Ser Gly Ser
     130                 135                 140                
 Gly Gly Arg Arg Arg Arg Ala Arg Arg Pro Lys Arg Thr Ile His Ile
 145                 150                 155                 160
 Asp Cys Glu Lys Arg Ile Thr Ser Cys Lys Gly Ala Gln Ala Asp Val
                 165                 170                 175    
 Val Leu Phe Phe Ile His Gly Val Gly Gly Ser Leu Ala Ile Trp Lys
             180                 185                 190        
 Glu Gln Leu Asp Phe Phe Val Arg Leu Gly Tyr Glu Val Val Ala Pro
         195                 200                 205            
 Asp Leu Ala Gly His Gly Ala Ser Ser Ala Pro Gln Val Ala Ala Ala
     210                 215                 220                
 Tyr Thr Phe Tyr Ala Leu Ala Glu Asp Met Arg Ala Ile Phe Lys Arg
 225                 230                 235                 240
 Tyr Ala Lys Lys Arg Asn Val Leu Ile Gly His Ser Tyr Gly Val Ser
                 245                 250                 255    
 Phe Cys Thr Phe Leu Ala His Glu Tyr Pro Asp Leu Val His Lys Val
             260                 265                 270        
 Ile Met Ile Asn Gly Gly Gly Pro Thr Ala Leu Glu Pro Ser Phe Cys
         275                 280                 285            
 Ser Ile Phe Asn Met Pro Thr Cys Val Leu His Cys Leu Ser Pro Cys
     290                 295                 300                
 Leu Ala Trp Ser Phe Leu Lys Ala Gly Phe Ala Arg Gln Gly Ala Lys
 305                 310                 315                 320
 Glu Lys Gln Leu Leu Lys Glu Gly Asn Ala Phe Asn Val Ser Ser Phe
                 325                 330                 335    
 Val Leu Arg Ala Met Met Ser Gly Gln Tyr Trp Pro Glu Gly Asp Glu
             340                 345                 350        
 Val Tyr His Ala Glu Leu Thr Val Pro Val Leu Leu Val His Gly Met
         355                 360                 365            
 His Asp Lys Phe Val Pro Val Glu Glu Asp Gln Arg Met Ala Glu Ile
     370                 375                 380                
 Leu Leu Leu Ala Phe Leu Lys Leu Ile Asp Glu Gly Ser His Met Val
 385                 390                 395                 400
 Met Leu Glu Cys Pro Glu Thr Val Asn Thr Leu Leu His Glu Phe Leu
                 405                 410                 415    
 Leu Trp Glu Pro Glu Pro Ser Pro Asn Gly Ser Thr Trp Met Pro His
             420                 425                 430        
 Asp Thr Ala Ala Tyr Gln Glu
         435                



      <210> 414
      <211> 355
      <212> PRT
      <213> Homo sapiens


      <400> 414
 Met Ser Val Asn Tyr Ala Ala Gly Leu Ser Pro Tyr Ala Asp Lys Gly
   1               5                  10                  15    
 Lys Cys Gly Leu Pro Glu Ile Phe Asp Pro Pro Glu Glu Leu Glu Arg
              20                  25                  30        
 Lys Val Trp Glu Leu Ala Arg Leu Val Trp Gln Ser Ser Ser Val Val
          35                  40                  45            
 Phe His Thr Gly Ala Gly Ile Ser Thr Ala Ser Gly Ile Pro Asp Phe
      50                  55                  60                
 Arg Gly Pro His Gly Val Trp Thr Met Glu Glu Arg Gly Leu Ala Pro
  65                  70                  75                  80
 Lys Phe Asp Thr Thr Phe Glu Ser Ala Arg Pro Thr Gln Thr His Met
                  85                  90                  95    
 Ala Leu Val Gln Leu Glu Arg Val Gly Leu Leu Arg Phe Leu Val Ser
             100                 105                 110        
 Gln Asn Val Asp Gly Leu His Val Arg Ser Gly Phe Pro Arg Asp Lys
         115                 120                 125            
 Leu Ala Glu Leu His Gly Asn Met Phe Val Glu Glu Cys Ala Lys Cys
     130                 135                 140                
 Lys Thr Gln Tyr Val Arg Asp Thr Val Val Gly Thr Met Gly Leu Lys
 145                 150                 155                 160
 Ala Thr Gly Arg Leu Cys Thr Val Ala Lys Ala Arg Gly Leu Arg Ala
                 165                 170                 175    
 Cys Arg Gly Glu Leu Arg Asp Thr Ile Leu Asp Trp Glu Asp Ser Leu
             180                 185                 190        
 Pro Asp Arg Asp Leu Ala Leu Ala Asp Glu Ala Ser Arg Asn Ala Asp
         195                 200                 205            
 Leu Ser Ile Thr Leu Gly Thr Ser Leu Gln Ile Arg Pro Ser Gly Asn
     210                 215                 220                
 Leu Pro Leu Ala Thr Lys Arg Arg Gly Gly Arg Leu Val Ile Val Asn
 225                 230                 235                 240
 Leu Gln Pro Thr Lys His Asp Arg His Ala Asp Leu Arg Ile His Gly
                 245                 250                 255    
 Tyr Val Asp Glu Val Met Thr Arg Leu Met Glu His Leu Gly Leu Glu
             260                 265                 270        
 Ile Pro Ala Trp Asp Gly Pro Arg Val Leu Glu Arg Ala Leu Pro Pro
         275                 280                 285            
 Leu Pro Arg Pro Pro Thr Pro Lys Leu Glu Pro Lys Glu Glu Ser Pro
     290                 295                 300                
 Thr Arg Ile Asn Gly Ser Ile Pro Ala Gly Pro Lys Gln Glu Pro Cys
 305                 310                 315                 320
 Ala Gln His Asn Gly Ser Glu Pro Ala Ser Pro Lys Arg Glu Arg Pro
                 325                 330                 335    
 Thr Ser Pro Ala Pro His Arg Pro Pro Lys Arg Val Lys Ala Lys Ala
             340                 345                 350        
 Val Pro Ser
         355



      <210> 415
      <211> 268
      <212> PRT
      <213> Homo sapiens


      <400> 415
 Met Ser Gly Lys Ala Asn Ala Ser Lys Lys Asn Ala Gln Gln Leu Lys
   1               5                  10                  15    
 Arg Asn Pro Lys Arg Lys Lys Asp Asn Glu Glu Val Val Leu Ser Glu
              20                  25                  30        
 Asn Lys Val Arg Asn Thr Val Lys Lys Asn Lys Asn His Leu Lys Asp
          35                  40                  45            
 Leu Ser Ser Glu Gly Gln Thr Lys His Thr Asn Leu Lys His Gly Lys
      50                  55                  60                
 Thr Ala Ala Ser Lys Arg Lys Thr Trp Gln Pro Leu Ser Lys Ser Thr
  65                  70                  75                  80
 Arg Asp His Leu Gln Thr Met Met Glu Ser Val Ile Met Thr Ile Leu
                  85                  90                  95    
 Ser Asn Ser Ile Lys Glu Lys Glu Glu Ile Gln Tyr His Leu Asn Phe
             100                 105                 110        
 Leu Lys Lys Arg Leu Leu Gln Gln Cys Glu Thr Leu Lys Val Pro Pro
         115                 120                 125            
 Lys Lys Met Glu Asp Leu Thr Asn Val Ser Ser Leu Leu Asn Met Glu
     130                 135                 140                
 Arg Ala Arg Asp Lys Ala Asn Glu Glu Gly Leu Ala Leu Leu Gln Glu
 145                 150                 155                 160
 Glu Ile Asp Lys Met Val Glu Thr Thr Glu Leu Met Thr Gly Asn Ile
                 165                 170                 175    
 Gln Ser Leu Lys Asn Lys Ile Gln Ile Leu Ala Ser Glu Val Glu Glu
             180                 185                 190        
 Glu Glu Glu Arg Val Lys Gln Met His Gln Ile Asn Ser Ser Gly Val
         195                 200                 205            
 Leu Ser Leu Pro Glu Leu Ser Gln Lys Thr Leu Lys Ala Pro Thr Leu
     210                 215                 220                
 Gln Lys Glu Ile Leu Ala Leu Ile Pro Asn Gln Asn Ala Leu Leu Lys
 225                 230                 235                 240
 Asp Leu Asp Ile Leu His Asn Ser Ser Gln Met Lys Ser Met Ser Thr
                 245                 250                 255    
 Phe Ile Glu Glu Ala Tyr Lys Lys Leu Asp Ala Ser
             260                 265            



      <210> 416
      <211> 652
      <212> PRT
      <213> Homo sapiens


      <400> 416
 Met His Cys Leu Gly Ala Glu Tyr Leu Val Ser Ala Glu Gly Ala Pro
   1               5                  10                  15    
 Arg Gln Arg Glu Trp Arg Pro Gln Ile Tyr Arg Lys Cys Thr Asp Thr
              20                  25                  30        
 Ala Trp Leu Phe Leu Phe Phe Leu Phe Trp Thr Gly Leu Val Phe Ile
          35                  40                  45            
 Met Gly Tyr Ser Val Val Ala Gly Ala Ala Gly Arg Leu Leu Phe Gly
      50                  55                  60                
 Tyr Asp Ser Phe Gly Asn Met Cys Gly Lys Lys Asn Ser Pro Val Glu
  65                  70                  75                  80
 Gly Ala Pro Leu Ser Gly Gln Asp Met Thr Leu Lys Lys His Val Phe
                  85                  90                  95    
 Phe Met Asn Ser Cys Asn Leu Glu Val Lys Gly Thr Gln Leu Asn Arg
             100                 105                 110        
 Met Ala Leu Cys Val Ser Asn Cys Pro Glu Glu Gln Leu Asp Ser Leu
         115                 120                 125            
 Glu Glu Val Gln Phe Phe Ala Asn Thr Ser Gly Ser Phe Leu Cys Val
     130                 135                 140                
 Tyr Ser Leu Asn Ser Phe Asn Tyr Thr His Ser Pro Lys Ala Asp Ser
 145                 150                 155                 160
 Leu Cys Pro Arg Leu Pro Val Pro Pro Ser Lys Ser Phe Pro Leu Phe
                 165                 170                 175    
 Asn Arg Cys Val Pro Gln Thr Pro Glu Cys Tyr Ser Leu Phe Ala Ser
             180                 185                 190        
 Val Leu Ile Asn Asp Val Asp Thr Leu His Arg Ile Leu Ser Gly Ile
         195                 200                 205            
 Met Ser Gly Arg Asp Thr Ile Leu Gly Leu Cys Ile Leu Ala Leu Ala
     210                 215                 220                
 Leu Ser Leu Ala Met Met Phe Thr Phe Arg Phe Ile Thr Thr Leu Leu
 225                 230                 235                 240
 Val His Ile Phe Ile Ser Leu Val Ile Leu Gly Leu Leu Phe Val Cys
                 245                 250                 255    
 Gly Val Leu Trp Trp Leu Tyr Tyr Asp Tyr Thr Asn Asp Leu Ser Ile
             260                 265                 270        
 Glu Leu Asp Thr Glu Arg Glu Asn Met Lys Cys Val Leu Gly Phe Ala
         275                 280                 285            
 Ile Val Ser Thr Gly Ile Thr Ala Val Leu Leu Val Leu Ile Phe Val
     290                 295                 300                
 Leu Arg Lys Arg Ile Lys Leu Thr Val Glu Leu Phe Gln Ile Thr Asn
 305                 310                 315                 320
 Lys Ala Ile Ser Ser Ala Pro Phe Leu Leu Phe Gln Pro Leu Trp Thr
                 325                 330                 335    
 Phe Ala Ile Leu Ile Phe Phe Trp Val Leu Trp Val Ala Val Leu Leu
             340                 345                 350        
 Ser Leu Gly Thr Ala Gly Ala Ala Gln Val Met Glu Gly Gly Gln Val
         355                 360                 365            
 Glu Tyr Lys Pro Leu Ser Gly Ile Arg Tyr Met Trp Ser Tyr His Leu
     370                 375                 380                
 Ile Gly Leu Ile Trp Thr Ser Glu Phe Ile Leu Ala Cys Gln Gln Met
 385                 390                 395                 400
 Thr Ile Ala Gly Ala Val Val Thr Cys Tyr Phe Asn Arg Ser Lys Asn
                 405                 410                 415    
 Asp Pro Pro Asp His Pro Ile Leu Ser Ser Leu Ser Ile Leu Phe Phe
             420                 425                 430        
 Tyr His Gln Gly Thr Ile Val Lys Gly Ser Phe Leu Ile Ser Val Val
         435                 440                 445            
 Arg Ile Pro Arg Ile Ile Val Met Tyr Met Gln Asn Ala Leu Lys Glu
     450                 455                 460                
 Gln His Gly Ala Leu Ser Arg Tyr Leu Phe Arg Cys Cys Tyr Cys Cys
 465                 470                 475                 480
 Phe Trp Cys Leu Asp Lys Tyr Leu Leu His Leu Asn Gln Asn Ala Tyr
                 485                 490                 495    
 Thr Thr Thr Ala Ile Asn Gly Thr Asp Phe Cys Thr Ser Ala Lys Asp
             500                 505                 510        
 Ala Phe Lys Ile Leu Ser Lys Asn Ser Ser His Phe Thr Ser Ile Asn
         515                 520                 525            
 Cys Phe Gly Asp Phe Ile Ile Phe Leu Gly Lys Val Leu Val Val Cys
     530                 535                 540                
 Phe Thr Val Phe Gly Gly Leu Met Ala Phe Asn Tyr Asn Arg Ala Phe
 545                 550                 555                 560
 Gln Val Trp Ala Val Pro Leu Leu Leu Val Ala Phe Phe Ala Tyr Leu
                 565                 570                 575    
 Val Ala His Ser Phe Leu Ser Val Phe Glu Thr Val Leu Asp Ala Leu
             580                 585                 590        
 Phe Leu Cys Phe Ala Val Asp Leu Glu Thr Asn Asp Gly Ser Ser Glu
         595                 600                 605            
 Lys Pro Tyr Phe Met Asp Gln Glu Phe Leu Ser Phe Val Lys Arg Ser
     610                 615                 620                
 Asn Lys Leu Asn Asn Ala Arg Ala Gln Gln Asp Lys His Ser Leu Arg
 625                 630                 635                 640
 Asn Glu Glu Gly Thr Glu Leu Gln Ala Ile Val Arg
                 645                 650        



      <210> 417
      <211> 263
      <212> PRT
      <213> Homo sapiens


      <400> 417
 Met Ala Phe Leu Trp Leu Val Ser Cys Phe Ala Leu Val Gly Ala Thr
   1               5                  10                  15    
 Phe Gly Cys Gly Val Pro Ala Ile Gln Pro Val Leu Thr Gly Leu Ser
              20                  25                  30        
 Arg Ile Val Asn Gly Glu Asp Ala Ile Pro Gly Ser Trp Pro Trp Gln
          35                  40                  45            
 Val Ser Leu Gln Asp Arg Thr Gly Phe His Phe Cys Gly Gly Ser Leu
      50                  55                  60                
 Ile Ser Glu Asn Trp Val Val Thr Ala Ala His Cys Gly Val Lys Thr
  65                  70                  75                  80
 Thr Asp Val Val Val Ala Gly Glu Phe Asp Gln Gly Ser Asp Glu Glu
                  85                  90                  95    
 Asn Val Gln Val Leu Lys Ile Ala Gln Val Phe Lys Asn Pro Lys Phe
             100                 105                 110        
 Asn Ser Phe Thr Val Arg Asn Asp Ile Thr Leu Leu Lys Leu Ala Thr
         115                 120                 125            
 Pro Ala Gln Phe Ser Glu Thr Val Ser Ala Val Cys Leu Pro Thr Val
     130                 135                 140                
 Asp Asp Asp Phe Pro Ala Gly Thr Leu Cys Ala Thr Thr Gly Trp Gly
 145                 150                 155                 160
 Lys Thr Lys Tyr Asn Ala Leu Lys Thr Pro Asp Lys Leu Gln Gln Ala
                 165                 170                 175    
 Ala Leu Pro Ile Val Ser Glu Ala Lys Cys Lys Glu Ser Trp Gly Ser
             180                 185                 190        
 Lys Ile Thr Asp Val Met Ile Cys Ala Gly Pro Ser Gly Val Ser Ser
         195                 200                 205            
 Cys Met Gly Asp Ser Gly Gly Pro Leu Val Cys Gln Lys Asp Gly Val
     210                 215                 220                
 Trp Thr Leu Ala Gly Ile Val Ser Trp Gly Ser Gly Phe Cys Ser Thr
 225                 230                 235                 240
 Ser Thr Pro Ala Val Tyr Ala Arg Val Thr Ala Leu Met Pro Trp Val
                 245                 250                 255    
 Gln Glu Ile Leu Glu Ala Asn
             260            



      <210> 418
      <211> 264
      <212> PRT
      <213> Homo sapiens


      <400> 418
 Met His Cys Ile Trp His Lys Gln Met Val Ser Ser Tyr Phe Phe Tyr
   1               5                  10                  15    
 Gln Lys Lys Asn Glu Leu Ser Asn Phe Glu Glu Val Phe Leu Lys Thr
              20                  25                  30        
 Ala Ser Gly Met Phe Phe Ser Thr Val Gly Cys His Pro Thr Arg Cys
          35                  40                  45            
 Gly Glu Phe Glu Lys Asn Asn Pro Asp Leu Tyr Leu Lys Glu Leu Leu
      50                  55                  60                
 Asn Leu Ala Glu Asn Asn Lys Gly Lys Val Val Ala Val Gly Glu Cys
  65                  70                  75                  80
 Gly Leu Asp Phe Asp Arg Leu His Phe Cys Pro Lys Asp Thr Gln Leu
                  85                  90                  95    
 Lys Tyr Cys Glu Lys Gln Phe Glu Leu Ser Glu Gln Thr Lys Leu Pro
             100                 105                 110        
 Met Phe Leu His Cys Arg Asn Ser His Ala Glu Phe Leu Asp Ile Ile
         115                 120                 125            
 Lys Arg Asn Arg Asp Arg Cys Val Gly Gly Val Val His Ser Phe Asp
     130                 135                 140                
 Gly Thr Lys Glu Ala Ala Ala Ala Leu Ile Asp Leu Asp Leu Tyr Ile
 145                 150                 155                 160
 Gly Phe Asn Gly Cys Ser Leu Lys Thr Glu Ala Asn Leu Glu Val Leu
                 165                 170                 175    
 Lys Ser Ile Pro Ser Glu Lys Leu Met Ile Glu Thr Asp Ala Pro Trp
             180                 185                 190        
 Cys Gly Val Lys Ser Thr His Ala Gly Ser Lys Tyr Ile Arg Thr Ala
         195                 200                 205            
 Phe Pro Thr Lys Lys Lys Trp Glu Ser Gly His Cys Leu Lys Asp Arg
     210                 215                 220                
 Asn Glu Pro Cys His Ile Ile Gln Ile Leu Glu Ile Met Ser Ala Val
 225                 230                 235                 240
 Arg Asp Glu Asp Pro Leu Glu Leu Ala Asn Thr Leu Tyr Asn Asn Thr
                 245                 250                 255    
 Ile Lys Val Phe Phe Pro Gly Ile
             260                



      <210> 419
      <211> 136
      <212> PRT
      <213> Homo sapiens


      <400> 419
 Met Arg Arg Val Phe Lys Ile Gln Leu His Thr Trp Ile Val Asp Met
   1               5                  10                  15    
 Glu Gly Ala Pro Gly Thr Leu Tyr Glu Gly Glu Lys Phe Gln Leu Leu
              20                  25                  30        
 Phe Lys Phe Ser Ser Arg Tyr Pro Phe Asp Ser Ser Gln Val Met Phe
          35                  40                  45            
 Thr Gly Glu Asn Ile Pro Val His Pro His Val Tyr Ser Asn Gly His
      50                  55                  60                
 Ile Cys Leu Ser Ile Leu Thr Glu Asp Trp Ser Pro Ala Leu Ser Val
  65                  70                  75                  80
 Gln Ser Val Cys Leu Ser Ile Ile Ser Met Leu Ser Ser Cys Lys Glu
                  85                  90                  95    
 Lys Arg Arg Pro Pro Asp Asn Ser Phe Tyr Val Arg Thr Cys Asn Lys
             100                 105                 110        
 Asn Pro Lys Lys Thr Lys Trp Trp Tyr His Gly Lys Phe Glu His Arg
         115                 120                 125            
 Asp Ile His Lys Gly Lys Lys Met
     130                 135    



      <210> 420
      <211> 260
      <212> PRT
      <213> Homo sapiens


      <400> 420
 Met Ser Leu Gln Lys Thr Pro Pro Thr Arg Val Phe Val Glu Leu Val
   1               5                  10                  15    
 Pro Trp Ala Asp Arg Ser Arg Glu Asn Asn Leu Ala Ser Gly Arg Glu
              20                  25                  30        
 Thr Leu Pro Gly Leu Arg His Pro Leu Ser Ser Thr Gln Ala Gln Thr
          35                  40                  45            
 Ala Thr Arg Glu Val Gln Val Ser Gly Thr Ser Glu Val Ser Ala Gly
      50                  55                  60                
 Pro Asp Arg Ala Gln Val Val Val Arg Val Ser Ser Thr Lys Glu Ala
  65                  70                  75                  80
 Ala Ala Glu Ala Lys Lys Ser Val Cys Arg Arg Leu Asp Tyr Ile Thr
                  85                  90                  95    
 Gln Ser Leu Gln Gln Gln Gly Val Gln Ala Glu Asn Ile Thr Val Thr
             100                 105                 110        
 Lys Asp Phe Arg Arg Val Glu Asn Ala Tyr His Met Glu Ala Glu Val
         115                 120                 125            
 Cys Ile Thr Phe Thr Glu Phe Gly Lys Met Gln Asn Ile Cys Asn Phe
     130                 135                 140                
 Leu Val Glu Lys Leu Asp Ser Ser Val Val Ile Ser Pro Pro Gln Phe
 145                 150                 155                 160
 Tyr His Thr Pro Gly Ser Val Glu Asn Leu Arg Arg Gln Ala Cys Leu
                 165                 170                 175    
 Val Ala Val Glu Asn Ala Trp Arg Lys Ala Gln Glu Val Cys Asn Leu
             180                 185                 190        
 Val Gly Gln Thr Leu Gly Lys Pro Leu Leu Ile Lys Glu Glu Glu Thr
         195                 200                 205            
 Lys Glu Trp Glu Gly Gln Ile Asp Asp His Gln Ser Ser Arg Leu Ser
     210                 215                 220                
 Ser Ser Leu Thr Val Gln Gln Lys Ile Lys Ser Ala Thr Ile His Ala
 225                 230                 235                 240
 Ala Ser Lys Val Phe Ile Thr Phe Glu Val Lys Gly Lys Glu Lys Arg
                 245                 250                 255    
 Lys Lys His Leu
             260



      <210> 421
      <211> 180
      <212> PRT
      <213> Homo sapiens


      <400> 421
 Met Ile Thr Glu Thr Ala Ala Glu Pro Thr Val Pro Ala Val Pro Ala
   1               5                  10                  15    
 Ala Glu Glu Ala Thr Glu Ala Arg Gly Arg Glu Glu Pro Ala Trp Pro
              20                  25                  30        
 Trp Lys Asp Ala Pro Ile Arg Thr Leu Val Gln Arg Ile His Gln Leu
          35                  40                  45            
 Gln Ala Glu Arg Ala Gln Gly Phe Arg Arg Leu Glu Glu Trp Leu Ala
      50                  55                  60                
 Pro Val Gln Gly Leu Arg Ala Trp Gly Arg Gly Leu Arg Val Pro Thr
  65                  70                  75                  80
 Cys Arg Arg Gly His Arg Gln Tyr Leu Arg Ser Gly Pro Asp Tyr Asp
                  85                  90                  95    
 Phe Ala Arg Tyr Arg Ser Thr Val His Gly Val Asp Pro Gly Leu Arg
             100                 105                 110        
 Arg Arg Leu Ala Gly Gly Ala Gly Gly Gly Ser Arg Ala Gly Arg Ala
         115                 120                 125            
 Ser Gln Ala Ala Ala Ala Arg Arg Pro Arg Ala Gln Pro Ala Gly Ala
     130                 135                 140                
 Gly Ala Asp Ala Ala Gly His Gly Gly Pro Ala Ala Val Asp Gly Asp
 145                 150                 155                 160
 Ala Arg Ala Gly Gly Ala Gly Gly Arg Cys Thr Asp Ala Ala Ala Glu
                 165                 170                 175    
 Asn Glu Gly Asn
             180



      <210> 422
      <211> 158
      <212> PRT
      <213> Homo sapiens


      <400> 422
 Met Ile Thr Glu Thr Ala Ala Glu Pro Thr Val Pro Ala Val Pro Ala
   1               5                  10                  15    
 Ala Glu Glu Ala Thr Glu Ala Arg Gly Arg Glu Glu Pro Ala Trp Pro
              20                  25                  30        
 Trp Lys Asp Ala Pro Ile Arg Thr Leu Val Gln Arg Ile His Gln Leu
          35                  40                  45            
 Gln Ala Glu Arg Ala Gln Gly Phe Arg Arg Leu Glu Glu Gly His Arg
      50                  55                  60                
 Gln Tyr Leu Arg Ser Gly Pro Asp Tyr Asp Phe Ala Arg Tyr Arg Ser
  65                  70                  75                  80
 Thr Val His Gly Val Asp Pro Gly Leu Arg Arg Arg Leu Ala Gly Gly
                  85                  90                  95    
 Ala Gly Gly Gly Ser Arg Ala Gly Arg Ala Ser Gln Ala Ala Ala Ala
             100                 105                 110        
 Arg Arg Pro Arg Ala Gln Pro Ala Gly Ala Gly Ala Asp Ala Ala Gly
         115                 120                 125            
 His Gly Gly Pro Ala Ala Val Asp Gly Asp Ala Arg Ala Gly Gly Ala
     130                 135                 140                
 Gly Gly Arg Cys Thr Asp Ala Ala Ala Glu Asn Glu Gly Asn
 145                 150                 155            



      <210> 423
      <211> 542
      <212> PRT
      <213> Homo sapiens


      <400> 423
 Met Gln Lys His Leu Lys Asn His Val Lys Lys Ile Gln Arg Gln Gln
   1               5                  10                  15    
 Ile Ala Ala Ala Gln Gln Asp Asp Gln Glu Val Thr Ala Leu Glu Glu
              20                  25                  30        
 Ile Asn Cys Ser Ser Ser Ser Ile Ser Phe Glu Asn Gly Asn Ser Asp
          35                  40                  45            
 Ser Lys Asp Leu Glu Val Glu Thr Leu Thr Ala Ser Ser Glu Gly Asn
      50                  55                  60                
 Lys Glu Val Ile Pro Glu His Val Ala Glu Phe Ile Glu Ile Pro Ile
  65                  70                  75                  80
 Ser Val Pro Glu Asp Val Ile Glu Asn Val Ile Glu Asn Gly Ser Pro
                  85                  90                  95    
 Asn Asn Ser Leu Asn Asn Val Phe Lys Pro Leu Thr Glu Cys Gly Asp
             100                 105                 110        
 Asp Tyr Glu Glu Glu Glu Asp Glu Glu Gly Asp Tyr Glu Glu Asp Asp
         115                 120                 125            
 Tyr Asp Leu Asn Gln Glu Thr Ser Val Ile His Lys Ile Asn Gly Thr
     130                 135                 140                
 Val Cys His Pro Lys Asp Ile Tyr Ala Thr Asp Gln Glu Gly Asn Phe
 145                 150                 155                 160
 Lys Cys Pro Ala Leu Gly Cys Val Arg Ile Phe Lys Arg Ile Gly Phe
                 165                 170                 175    
 Leu Asn Lys His Ala Met Thr Val His Pro Thr Asp Leu Asn Val Arg
             180                 185                 190        
 Gln Thr Val Met Lys Trp Ser Lys Gly Lys Cys Lys Phe Cys Gln Arg
         195                 200                 205            
 Gln Phe Glu Asp Ser Gln His Phe Ile Asp Gln Leu Asn Arg His Ser
     210                 215                 220                
 Tyr Pro Asn Val Tyr Phe Cys Leu His Phe Asn Cys Asn Glu Ser Phe
 225                 230                 235                 240
 Lys Leu Pro Phe Gln Leu Ala Gln His Thr Lys Ser His Arg Thr Phe
                 245                 250                 255    
 Gln Ala Gln Cys Ser Phe Pro Glu Cys His Glu Leu Phe Glu Asp Leu
             260                 265                 270        
 Pro Leu Leu Tyr Glu His Glu Ala Gln His Tyr Leu Ser Lys Thr Pro
         275                 280                 285            
 Glu Ser Ser Ala Gln Pro Ser Glu Thr Ile Leu Trp Asp Val Gln Thr
     290                 295                 300                
 Asp Ser Asn Pro Asn Gln Glu Lys Asp Ser Ser Ser Asn Glu Lys Gln
 305                 310                 315                 320
 Thr Ile Ser Leu Pro Val Ser Thr Ser Lys Ser Arg Lys Glu Ser Thr
                 325                 330                 335    
 Glu Pro Lys Thr Cys Ile Glu Ser Met Glu Lys Lys Thr Asp Ser Leu
             340                 345                 350        
 Val Gln Asn Gly Asn Glu Arg Ser Asp Asp Thr Val Ser Asn Ile Ser
         355                 360                 365            
 Leu Ile Asp Gln Lys Met Pro Asp Ile Glu Pro Asn Ser Glu Asn Asn
     370                 375                 380                
 Cys Ser Ser Ser Asp Ile Val Asn Gly His Ser Glu Ile Glu Gln Thr
 385                 390                 395                 400
 Pro Leu Val Ser Ser Asp Pro Ala Leu Lys Ile Asp Thr Asn Arg Ile
                 405                 410                 415    
 Arg Thr Glu Asn Gly Ser Ile Leu Pro Ser Val Val Pro Gln Glu His
             420                 425                 430        
 Asn Thr Leu Pro Val Ser Gln Ala Pro Ser Lys Pro Asn Leu Thr Ser
         435                 440                 445            
 Glu His Thr Ser Tyr Gly Leu Ile Leu Thr Lys Pro Tyr Val Arg Pro
     450                 455                 460                
 Leu Pro Pro Ser Tyr Leu Asp Glu Arg Tyr Leu Ser Met Pro Lys Arg
 465                 470                 475                 480
 Arg Lys Phe Leu Thr Asp Arg Val Asp Ala Cys Ser Asp Gln Asp Asn
                 485                 490                 495    
 Val Tyr Lys Lys Ser Val Lys Arg Leu Arg Cys Gly Lys Cys Leu Thr
             500                 505                 510        
 Thr Tyr Cys Asn Ala Glu Ala Leu Glu Ala His Leu Ala Gln Lys Lys
         515                 520                 525            
 Cys Gln Thr Leu Phe Gly Phe Asp Ser Asp Asp Glu Ser Ala
     530                 535                 540        



      <210> 424
      <211> 227
      <212> PRT
      <213> Homo sapiens


      <400> 424
 Met Ala Cys Thr Lys Thr Leu Gln Gln Ser Gln Pro Ile Ser Ala Gly
   1               5                  10                  15    
 Ala Thr Thr Thr Thr Thr Ala Val Ala Pro Ala Gly Gly His Ser Gly
              20                  25                  30        
 Ser Thr Glu Cys Asp Leu Glu Cys Leu Val Cys Arg Glu Pro Tyr Ser
          35                  40                  45            
 Cys Pro Arg Leu Pro Lys Leu Leu Ala Cys Gln His Ala Phe Cys Ala
      50                  55                  60                
 Ile Cys Leu Lys Leu Leu Leu Cys Val Gln Asp Asn Thr Trp Ser Ile
  65                  70                  75                  80
 Thr Cys Pro Leu Cys Arg Lys Val Thr Ala Val Pro Gly Gly Leu Ile
                  85                  90                  95    
 Cys Ser Leu Arg Asp His Glu Ala Val Val Gly Gln Leu Ala Gln Pro
             100                 105                 110        
 Cys Thr Glu Val Ser Leu Cys Pro Gln Gly Leu Val Asp Pro Ala Asp
         115                 120                 125            
 Leu Ala Ala Gly His Pro Ser Leu Val Gly Glu Asp Gly Gln Asp Glu
     130                 135                 140                
 Val Ser Ala Asn His Val Ala Ala Arg Arg Leu Ala Ala His Leu Leu
 145                 150                 155                 160
 Leu Leu Ala Leu Leu Ile Ile Leu Ile Gly Pro Phe Ile Tyr Pro Gly
                 165                 170                 175    
 Val Leu Arg Trp Val Leu Thr Phe Ile Ile Ala Leu Ala Leu Leu Met
             180                 185                 190        
 Ser Thr Leu Phe Cys Cys Leu Pro Ser Thr Arg Gly Ser Cys Trp Pro
         195                 200                 205            
 Ser Ser Arg Thr Leu Phe Cys Arg Glu Gln Lys His Ser His Ile Ser
     210                 215                 220                
 Ser Ile Ala
 225        



      <210> 425
      <211> 448
      <212> PRT
      <213> Homo sapiens


      <400> 425
 Met Arg Glu Asn Val Val Val Ser Asn Met Glu Arg Glu Ser Gly Lys
   1               5                  10                  15    
 Pro Val Ala Val Val Ala Val Val Thr Glu Pro Trp Phe Thr Gln Arg
              20                  25                  30        
 Tyr Arg Glu Tyr Leu Gln Arg Gln Lys Leu Phe Asp Thr Gln His Arg
          35                  40                  45            
 Val Glu Lys Met Pro Asp Gly Ser Val Ala Leu Pro Val Leu Gly Glu
      50                  55                  60                
 Thr Leu Pro Glu Gln His Leu Gln Glu Leu Arg Asn Arg Val Ala Pro
  65                  70                  75                  80
 Gly Ser Pro Cys Met Leu Thr Gln Leu Pro Asp Pro Val Pro Ser Lys
                  85                  90                  95    
 Arg Ala Gln Gly Cys Ser Pro Ala Gln Lys Leu Cys Leu Glu Val Ser
             100                 105                 110        
 Arg Trp Val Glu Gly Arg Gly Val Lys Trp Ser Ala Glu Leu Glu Ala
         115                 120                 125            
 Asp Leu Pro Arg Ser Trp Gln Arg His Gly Asn Leu Leu Leu Leu Ser
     130                 135                 140                
 Glu Asp Cys Phe Gln Ala Lys Gln Trp Lys Asn Leu Gly Pro Glu Leu
 145                 150                 155                 160
 Trp Glu Thr Val Ala Leu Ala Leu Gly Val Gln Arg Leu Ala Lys Arg
                 165                 170                 175    
 Gly Arg Val Ser Pro Asp Gly Thr Arg Thr Pro Ala Val Thr Leu Leu
             180                 185                 190        
 Leu Gly Asp His Gly Trp Val Glu His Val Asp Asn Gly Ile Arg Tyr
         195                 200                 205            
 Lys Phe Asp Val Thr Gln Cys Met Phe Ser Phe Gly Asn Ile Thr Glu
     210                 215                 220                
 Lys Leu Arg Val Ala Ser Leu Ser Cys Ala Gly Glu Val Leu Val Asp
 225                 230                 235                 240
 Leu Tyr Ala Gly Ile Gly Tyr Phe Thr Leu Pro Phe Leu Val His Ala
                 245                 250                 255    
 Gly Ala Ala Phe Val His Ala Cys Glu Trp Asn Pro His Ala Val Val
             260                 265                 270        
 Ala Leu Arg Asn Asn Leu Glu Ile Asn Gly Val Ala Asp Arg Cys Gln
         275                 280                 285            
 Ile His Phe Gly Asp Asn Arg Lys Leu Lys Leu Ser Asn Ile Ala Asp
     290                 295                 300                
 Arg Val Ile Leu Gly Leu Ile Pro Ser Ser Glu Glu Gly Trp Pro Ile
 305                 310                 315                 320
 Ala Cys Gln Val Leu Arg Gln Asp Ala Gly Gly Ile Leu His Ile His
                 325                 330                 335    
 Gln Asn Val Glu Ser Phe Pro Gly Lys Asn Leu Gln Ala Leu Gly Val
             340                 345                 350        
 Ser Lys Val Glu Lys Glu His Trp Leu Tyr Pro Gln Gln Ile Thr Thr
         355                 360                 365            
 Asn Gln Trp Lys Asn Gly Ala Thr Arg Asp Ser Arg Gly Lys Met Leu
     370                 375                 380                
 Ser Pro Ala Thr Lys Pro Glu Trp Gln Arg Trp Ala Glu Ser Ala Glu
 385                 390                 395                 400
 Thr Arg Ile Ala Thr Leu Leu Gln Gln Val His Gly Lys Pro Trp Lys
                 405                 410                 415    
 Thr Gln Ile Leu His Ile Gln Pro Val Lys Ser Tyr Ala Pro His Val
             420                 425                 430        
 Asp His Ile Val Leu Asp Leu Glu Cys Cys Pro Cys Pro Ser Val Gly
         435                 440                 445            





      <210> 426
      <211> 672
      <212> PRT
      <213> Homo sapiens


      <400> 426
 Met Gly Val Gly Arg Leu Asp Met Tyr Val Leu His Pro Pro Ser Ala
   1               5                  10                  15    
 Gly Ala Glu Arg Thr Leu Ala Ser Val Cys Ala Leu Leu Val Trp His
              20                  25                  30        
 Pro Ala Gly Pro Gly Glu Lys Val Val Arg Val Leu Phe Pro Gly Cys
          35                  40                  45            
 Thr Pro Pro Ala Cys Leu Leu Asp Gly Leu Val Arg Leu Gln His Leu
      50                  55                  60                
 Arg Phe Leu Arg Glu Pro Val Val Thr Pro Gln Asp Leu Glu Gly Pro
  65                  70                  75                  80
 Gly Arg Ala Glu Ser Lys Glu Ser Val Gly Ser Arg Asp Ser Ser Lys
                  85                  90                  95    
 Arg Glu Gly Leu Leu Ala Thr His Pro Arg Pro Gly Gln Glu Arg Pro
             100                 105                 110        
 Gly Val Ala Arg Lys Glu Pro Ala Arg Ala Glu Ala Pro Arg Lys Thr
         115                 120                 125            
 Glu Lys Glu Ala Lys Thr Pro Arg Glu Leu Lys Lys Asp Pro Lys Pro
     130                 135                 140                
 Ser Val Ser Arg Thr Gln Pro Arg Glu Val Arg Arg Ala Ala Ser Ser
 145                 150                 155                 160
 Val Pro Asn Leu Lys Lys Thr Asn Ala Gln Ala Ala Pro Lys Pro Arg
                 165                 170                 175    
 Lys Ala Pro Ser Thr Ser His Ser Gly Phe Pro Pro Val Ala Asn Gly
             180                 185                 190        
 Pro Arg Ser Pro Pro Ser Leu Arg Cys Gly Glu Ala Ser Pro Pro Ser
         195                 200                 205            
 Ala Ala Cys Gly Ser Pro Ala Ser Gln Leu Val Ala Thr Pro Ser Leu
     210                 215                 220                
 Glu Leu Gly Pro Ile Pro Ala Gly Glu Glu Lys Ala Leu Glu Leu Pro
 225                 230                 235                 240
 Leu Ala Ala Ser Ser Ile Pro Arg Pro Arg Thr Pro Ser Pro Glu Ser
                 245                 250                 255    
 His Arg Ser Pro Ala Glu Gly Ser Glu Arg Leu Ser Leu Ser Pro Leu
             260                 265                 270        
 Arg Gly Gly Glu Ala Gly Pro Asp Ala Ser Pro Thr Val Thr Thr Pro
         275                 280                 285            
 Thr Val Thr Thr Pro Ser Leu Pro Ala Glu Val Gly Ser Pro His Ser
     290                 295                 300                
 Thr Glu Val Asp Glu Ser Leu Ser Val Ser Phe Glu Gln Val Leu Pro
 305                 310                 315                 320
 Pro Ser Ala Pro Thr Ser Glu Ala Gly Leu Ser Leu Pro Leu Arg Gly
                 325                 330                 335    
 Pro Arg Ala Arg Arg Ser Ala Ser Pro His Asp Val Asp Leu Cys Leu
             340                 345                 350        
 Val Ser Pro Cys Glu Phe Glu His Arg Lys Ala Val Pro Met Ala Pro
         355                 360                 365            
 Ala Pro Ala Ser Pro Gly Ser Ser Asn Asp Ser Ser Ala Arg Ser Gln
     370                 375                 380                
 Glu Arg Ala Gly Gly Leu Gly Ala Glu Glu Thr Pro Pro Thr Ser Val
 385                 390                 395                 400
 Ser Glu Ser Leu Pro Thr Leu Ser Asp Ser Asp Pro Val Pro Leu Ala
                 405                 410                 415    
 Pro Gly Ala Ala Asp Ser Asp Glu Asp Thr Glu Gly Phe Gly Val Pro
             420                 425                 430        
 Arg His Asp Pro Leu Pro Asp Pro Leu Lys Val Pro Pro Pro Leu Pro
         435                 440                 445            
 Asp Pro Ser Ser Ile Cys Met Val Asp Pro Glu Met Leu Pro Pro Lys
     450                 455                 460                
 Thr Ala Arg Gln Thr Glu Asn Val Ser Arg Thr Arg Lys Pro Leu Ala
 465                 470                 475                 480
 Arg Pro Asn Ser Arg Ala Ala Ala Pro Lys Ala Thr Pro Val Ala Ala
                 485                 490                 495    
 Ala Lys Thr Lys Gly Leu Ala Gly Gly Asp Arg Ala Ser Arg Pro Leu
             500                 505                 510        
 Ser Ala Arg Ser Glu Pro Ser Glu Lys Gly Gly Arg Ala Pro Leu Ser
         515                 520                 525            
 Arg Lys Ser Ser Thr Pro Lys Thr Ala Thr Arg Gly Pro Ser Gly Ser
     530                 535                 540                
 Ala Ser Ser Arg Pro Gly Val Ser Ala Thr Pro Pro Lys Ser Pro Val
 545                 550                 555                 560
 Tyr Leu Asp Leu Ala Tyr Leu Pro Ser Gly Ser Ser Ala His Leu Val
                 565                 570                 575    
 Asp Glu Glu Phe Phe Gln Arg Val Arg Ala Leu Cys Tyr Val Ile Ser
             580                 585                 590        
 Gly Gln Asp Gln Arg Lys Glu Glu Gly Met Arg Ala Val Leu Asp Ala
         595                 600                 605            
 Leu Leu Ala Ser Lys Gln His Trp Asp Arg Asp Leu Gln Val Thr Leu
     610                 615                 620                
 Ile Pro Thr Phe Asp Ser Val Ala Met His Thr Trp Tyr Ala Glu Thr
 625                 630                 635                 640
 His Ala Arg His Gln Ala Leu Gly Ile Thr Val Leu Gly Ser Asn Ser
                 645                 650                 655    
 Met Val Ser Met Gln Asp Asp Ala Phe Pro Ala Cys Lys Val Glu Phe
             660                 665                 670        





      <210> 427
      <211> 941
      <212> PRT
      <213> Homo sapiens


      <400> 427
 Met Tyr Gln Gly Glu Phe Gly Leu Asn Met Lys Leu Gly Tyr Gly Lys
   1               5                  10                  15    
 Phe Ser Trp Pro Thr Gly Glu Ser Tyr His Gly Gln Phe Tyr Arg Asp
              20                  25                  30        
 His Cys His Gly Leu Gly Thr Tyr Met Trp Pro Asp Gly Ser Ser Phe
          35                  40                  45            
 Thr Gly Thr Phe Tyr Leu Ser His Arg Glu Gly Tyr Gly Thr Met Tyr
      50                  55                  60                
 Met Lys Thr Arg Leu Phe Gln Gly Leu Tyr Lys Ala Asp Gln Arg Phe
  65                  70                  75                  80
 Gly Pro Gly Val Glu Thr Tyr Pro Asp Gly Ser Gln Asp Val Gly Leu
                  85                  90                  95    
 Trp Phe Arg Glu Gln Leu Ile Lys Leu Cys Thr Gln Ile Pro Ser Gly
             100                 105                 110        
 Phe Ser Leu Leu Arg Tyr Pro Glu Phe Ser Ser Phe Ile Thr His Ser
         115                 120                 125            
 Pro Ala Arg Ile Ser Leu Ser Glu Glu Glu Lys Thr Glu Trp Gly Leu
     130                 135                 140                
 Gln Glu Gly Gln Asp Pro Phe Phe Tyr Asp Tyr Lys Arg Phe Leu Leu
 145                 150                 155                 160
 Asn Asp Asn Leu Thr Leu Pro Pro Glu Met Tyr Val Tyr Ser Thr Asn
                 165                 170                 175    
 Ser Asp His Leu Pro Met Thr Ser Ser Phe Arg Lys Glu Leu Asp Ala
             180                 185                 190        
 Arg Ile Phe Leu Asn Glu Ile Pro Pro Phe Val Glu Asp Gly Glu Pro
         195                 200                 205            
 Trp Phe Ile Ile Asn Glu Thr Pro Leu Leu Val Lys Ile Gln Lys Gln
     210                 215                 220                
 Thr Tyr Lys Phe Arg Asn Lys Pro Ala His Thr Ser Trp Asn Met Gly
 225                 230                 235                 240
 Ala Ile Leu Glu Gly Lys Arg Ser Gly Phe Ala Pro Cys Gly Pro Lys
                 245                 250                 255    
 Glu Gln Leu Ser Met Glu Met Ile Leu Lys Ala Glu Glu Gly Asn His
             260                 265                 270        
 Glu Trp Ile Cys Arg Ile Leu Lys Asp Asn Phe Ala Ser Ala Asp Val
         275                 280                 285            
 Ala Asp Ala Lys Gly Tyr Thr Val Leu Ala Ala Ala Ala Thr His Cys
     290                 295                 300                
 His Asn Asp Ile Val Asn Leu Leu Leu Asp Cys Gly Ala Asp Val Asn
 305                 310                 315                 320
 Lys Cys Ser Asp Glu Gly Leu Thr Ala Leu Ser Met Cys Phe Leu Leu
                 325                 330                 335    
 His Tyr Pro Ala Gln Ser Phe Lys Pro Asn Val Ala Glu Arg Thr Ile
             340                 345                 350        
 Pro Glu Pro Gln Glu Pro Pro Lys Phe Pro Val Val Pro Ile Leu Ser
         355                 360                 365            
 Ser Ser Phe Met Asp Thr Asn Leu Glu Ser Leu Tyr Tyr Glu Val Asn
     370                 375                 380                
 Val Pro Ser Gln Gly Ser Tyr Glu Leu Arg Pro Pro Pro Ala Pro Leu
 385                 390                 395                 400
 Leu Leu Pro Arg Val Ser Gly Ser His Glu Gly Gly His Phe Gln Asp
                 405                 410                 415    
 Thr Gly Gln Cys Gly Gly Ser Met Asp His Arg Ser Ser Ser Leu Lys
             420                 425                 430        
 Gly Asp Ser Pro Leu Val Lys Gly Ser Leu Gly His Val Glu Ser Gly
         435                 440                 445            
 Leu Glu Asp Val Leu Gly Asn Thr Asp Arg Gly Ser Leu Cys Ser Ala
     450                 455                 460                
 Glu Thr Lys Phe Glu Ser Asn Val Cys Val Cys Asp Phe Ser Ile Glu
 465                 470                 475                 480
 Leu Ser Gln Ala Met Leu Glu Arg Ser Ala Gln Ser His Ser Leu Leu
                 485                 490                 495    
 Lys Met Ala Ser Pro Ser Pro Cys Thr Ser Ser Phe Asp Lys Gly Thr
             500                 505                 510        
 Met Arg Arg Met Ala Leu Ser Met Ile Glu Arg Arg Lys Arg Trp Arg
         515                 520                 525            
 Thr Ile Lys Leu Leu Leu Arg Arg Gly Ala Asp Pro Asn Leu Cys Cys
     530                 535                 540                
 Val Pro Met Gln Val Leu Phe Leu Ala Val Lys Ala Gly Asp Val Asp
 545                 550                 555                 560
 Gly Val Arg Leu Leu Leu Glu His Gly Ala Arg Thr Asp Ile Cys Phe
                 565                 570                 575    
 Pro Pro Gln Leu Ser Thr Leu Thr Pro Leu His Ile Ala Ala Ala Leu
             580                 585                 590        
 Pro Gly Glu Glu Gly Val Gln Ile Val Glu Leu Leu Leu His Ala Ile
         595                 600                 605            
 Thr Asp Val Asp Ala Lys Ala Ser Asp Glu Asp Asp Thr Tyr Lys Pro
     610                 615                 620                
 Gly Lys Leu Asp Leu Leu Pro Ser Ser Leu Lys Leu Ser Asn Glu Pro
 625                 630                 635                 640
 Gly Pro Pro Gln Ala Tyr Tyr Ser Thr Asp Thr Ala Leu Pro Glu Glu
                 645                 650                 655    
 Gly Gly Arg Thr Ala Leu His Met Ala Cys Glu Arg Glu Asp Asp Asn
             660                 665                 670        
 Lys Cys Ala Arg Asp Ile Val Arg Leu Leu Leu Ser His Gly Ala Asn
         675                 680                 685            
 Pro Asn Leu Leu Trp Ser Gly His Ser Pro Leu Ser Leu Ser Ile Ala
     690                 695                 700                
 Ser Gly Asn Glu Leu Val Val Lys Glu Leu Leu Thr Gln Gly Ala Asp
 705                 710                 715                 720
 Pro Asn Leu Pro Leu Thr Lys Gly Leu Gly Ser Ala Leu Cys Val Ala
                 725                 730                 735    
 Cys Asp Leu Thr Tyr Glu His Gln Arg Asn Met Asp Ser Lys Leu Ala
             740                 745                 750        
 Leu Ile Asp Arg Leu Ile Ser His Gly Ala Asp Ile Leu Lys Pro Val
         755                 760                 765            
 Met Leu Arg Gln Gly Glu Lys Glu Ala Val Gly Thr Ala Val Asp Tyr
     770                 775                 780                
 Gly Tyr Phe Arg Phe Phe Gln Asp Arg Arg Ile Ala Arg Cys Pro Phe
 785                 790                 795                 800
 His Thr Leu Met Pro Ala Glu Arg Glu Thr Phe Leu Ala Arg Lys Arg
                 805                 810                 815    
 Leu Leu Glu Tyr Met Gly Leu Gln Leu Arg Gln Ala Val Phe Ala Lys
             820                 825                 830        
 Glu Ser Gln Trp Asp Pro Thr Trp Leu Tyr Leu Cys Lys Arg Ala Glu
         835                 840                 845            
 Leu Ile Pro Ser His Arg Met Lys Lys Lys Gly Pro Ser Leu Pro Arg
     850                 855                 860                
 Gly Leu Asp Val Lys Glu Gln Gly Gln Ile Pro Phe Phe Lys Phe Cys
 865                 870                 875                 880
 Tyr Gln Cys Gly Arg Ser Ile Gly Val Arg Leu Leu Pro Cys Pro Arg
                 885                 890                 895    
 Cys Tyr Gly Ile Leu Thr Cys Ser Lys Tyr Cys Lys Thr Lys Ala Trp
             900                 905                 910        
 Thr Glu Phe His Lys Lys Asp Cys Gly Asp Leu Val Ala Ile Val Thr
         915                 920                 925            
 Gln Leu Glu Gln Val Ser Arg Arg Arg Glu Glu Phe Gln
     930                 935                 940    



      <210> 428
      <211> 1359
      <212> PRT
      <213> Homo sapiens


      <400> 428
 Met Arg Arg Asn Ile Arg Lys Leu Leu Arg Glu Asp Gln Leu Glu Pro
   1               5                  10                  15    
 Val Thr Lys Ala Ala Gln Gln Glu Glu Leu Glu Arg Arg Lys Arg Leu
              20                  25                  30        
 Glu Gln Gln Arg Lys Asp Tyr Ala Ala Pro Ile Pro Thr Val Pro Leu
          35                  40                  45            
 Glu Phe Leu Pro Glu Glu Ile Ala Leu Arg Ala Ser Asp Gly Pro Gln
      50                  55                  60                
 Leu Pro Pro Arg Val Leu Ala Gln Glu Val Ile Cys Leu Asp Ser Ser
  65                  70                  75                  80
 Ser Gly Ser Glu Asp Glu Lys Ser Ser Arg Asp Glu Val Ile Glu Leu
                  85                  90                  95    
 Ser Ser Gly Glu Glu Asp Thr Leu His Ile Val Asp Ser Ser Glu Ser
             100                 105                 110        
 Val Ser Glu Asp Asp Glu Glu Glu Glu Lys Gly Gly Thr His Val Asn
         115                 120                 125            
 Asp Val Leu Asn Gln Arg Asp Ala Leu Gly Arg Val Leu Val Asn Leu
     130                 135                 140                
 Asn His Pro Pro Glu Glu Glu Asn Val Phe Leu Ala Pro Gln Leu Ala
 145                 150                 155                 160
 Arg Ala Val Lys Pro His Gln Ile Gly Gly Ile Arg Phe Leu Tyr Asp
                 165                 170                 175    
 Asn Leu Val Glu Ser Leu Glu Arg Phe Lys Thr Ser Ser Gly Phe Gly
             180                 185                 190        
 Cys Ile Leu Ala His Ser Met Gly Leu Gly Lys Thr Leu Gln Val Ile
         195                 200                 205            
 Ser Phe Ile Asp Val Leu Phe Arg His Thr Pro Ala Lys Thr Val Leu
     210                 215                 220                
 Ala Ile Val Pro Val Asn Thr Leu Gln Asn Trp Leu Ala Glu Phe Asn
 225                 230                 235                 240
 Met Trp Leu Pro Pro Pro Glu Ala Leu Pro Ala Asp Asn Lys Pro Glu
                 245                 250                 255    
 Glu Val Gln Pro Arg Phe Phe Lys Val His Ile Leu Asn Asp Glu His
             260                 265                 270        
 Lys Thr Met Ala Ser Arg Ala Lys Val Met Ala Asp Trp Val Ser Glu
         275                 280                 285            
 Gly Gly Val Leu Leu Met Gly Tyr Glu Met Tyr Arg Leu Leu Thr Leu
     290                 295                 300                
 Lys Lys Ser Phe Ala Thr Gly Arg Pro Lys Lys Thr Lys Lys Arg Ser
 305                 310                 315                 320
 His Pro Val Ile Ile Asp Leu Asp Glu Glu Asp Arg Gln Gln Glu Phe
                 325                 330                 335    
 Arg Arg Glu Phe Glu Lys Ala Leu Cys Arg Pro Gly Pro Asp Val Val
             340                 345                 350        
 Ile Cys Asp Glu Gly His Arg Ile Lys Asn Cys Gln Ala Ser Thr Ser
         355                 360                 365            
 Gln Ala Leu Lys Asn Ile Arg Ser Arg Arg Arg Val Val Leu Thr Gly
     370                 375                 380                
 Tyr Pro Leu Gln Asn Asn Leu Ile Glu Tyr Trp Cys Met Val Asp Phe
 385                 390                 395                 400
 Val Arg Pro Asp Phe Leu Gly Thr Arg Gln Glu Phe Ser Asn Met Phe
                 405                 410                 415    
 Glu Arg Pro Ile Leu Asn Gly Gln Cys Ile Asp Ser Thr Pro Gln Asp
             420                 425                 430        
 Val Arg Leu Met Arg Tyr Arg Ser His Val Leu His Ser Leu Leu Glu
         435                 440                 445            
 Gly Phe Val Gln Arg Arg Gly His Thr Val Leu Lys Ile His Leu Pro
     450                 455                 460                
 Ala Lys Glu Glu Asn Val Ile Leu Val Arg Leu Ser Lys Ile Gln Arg
 465                 470                 475                 480
 Asp Leu Tyr Thr Gln Phe Met Asp Arg Phe Arg Asp Cys Gly Ser Ser
                 485                 490                 495    
 Gly Trp Leu Gly Leu Asn Pro Leu Lys Ala Phe Cys Val Cys Cys Lys
             500                 505                 510        
 Ile Trp Asn His Pro Asp Val Leu Tyr Glu Ala Leu Gln Lys Glu Ser
         515                 520                 525            
 Leu Ala Asn Glu Gln Asp Leu Asp Val Glu Glu Leu Gly Ser Ala Gly
     530                 535                 540                
 Thr Ser Ala Arg Cys Pro Pro Gln Gly Thr Lys Gly Lys Gly Glu Asp
 545                 550                 555                 560
 Ser Thr Leu Ala Ser Ser Met Gly Glu Ala Thr Asn Ser Lys Phe Leu
                 565                 570                 575    
 Gln Gly Val Gly Phe Asn Pro Phe Gln Glu Arg Gly Asn Asn Ile Val
             580                 585                 590        
 Thr Tyr Glu Trp Ala Lys Asp Leu Leu Thr Asn Tyr Gln Thr Gly Val
         595                 600                 605            
 Leu Glu Asn Ser Pro Lys Met Val Leu Leu Phe His Leu Ile Glu Glu
     610                 615                 620                
 Ser Val Lys Leu Gly Asp Lys Ile Leu Val Phe Ser Gln Ser Leu Ser
 625                 630                 635                 640
 Thr Leu Ala Leu Ile Glu Glu Phe Leu Gly Lys Arg Glu Val Pro Cys
                 645                 650                 655    
 Pro Pro Gly Thr Glu Gly Gln Gly Ala Gln Lys Trp Val Arg Asn Ile
             660                 665                 670        
 Ser Tyr Phe Arg Leu Asp Gly Ser Thr Pro Ala Phe Glu Arg Glu Arg
         675                 680                 685            
 Leu Ile Asn Gln Phe Asn Asp Pro Ser Asn Leu Thr Thr Trp Leu Phe
     690                 695                 700                
 Leu Leu Ser Thr Arg Ala Gly Cys Leu Gly Val Asn Leu Ile Gly Ala
 705                 710                 715                 720
 Asn Arg Val Val Val Phe Asp Ala Ser Trp Asn Pro Cys His Asp Ala
                 725                 730                 735    
 Gln Ala Val Cys Arg Val Tyr Arg Tyr Gly Gln Lys Lys Pro Cys Tyr
             740                 745                 750        
 Ile Tyr Arg Leu Val Ala Asp Tyr Thr Leu Glu Lys Lys Ile Tyr Asp
         755                 760                 765            
 Arg Gln Ile Ser Lys Gln Gly Met Ser Asp Arg Val Val Asp Asp Leu
     770                 775                 780                
 Asn Pro Met Leu Asn Phe Thr Arg Lys Glu Val Glu Asn Leu Leu His
 785                 790                 795                 800
 Phe Val Glu Lys Glu Pro Ala Pro Gln Val Ser Leu Asn Val Lys Gly
                 805                 810                 815    
 Ile Lys Glu Ser Val Leu Gln Leu Ala Cys Leu Lys Tyr Pro His Leu
             820                 825                 830        
 Ile Thr Lys Glu Pro Phe Glu His Glu Ser Leu Leu Leu Asn Arg Lys
         835                 840                 845            
 Asp His Lys Leu Thr Lys Ala Glu Lys Lys Ala Ala Lys Lys Ser Tyr
     850                 855                 860                
 Glu Glu Asp Lys Arg Thr Ser Val Pro Tyr Thr Arg Pro Ser Tyr Ala
 865                 870                 875                 880
 Gln Tyr Tyr Pro Ala Ser Asp Gln Ser Leu Thr Ser Ile Pro Ala Phe
                 885                 890                 895    
 Ser Gln Arg Asn Trp Gln Pro Thr Leu Lys Gly Asp Glu Lys Pro Val
             900                 905                 910        
 Ala Ser Val Arg Pro Val Gln Ser Thr Pro Ile Pro Met Met Pro Arg
         915                 920                 925            
 His Val Pro Leu Gly Gly Ser Val Ser Ser Ala Ser Ser Thr Asn Pro
     930                 935                 940                
 Ser Met Asn Phe Pro Ile Asn Tyr Leu Gln Arg Ala Gly Val Leu Val
 945                 950                 955                 960
 Gln Lys Val Val Thr Thr Thr Asp Ile Val Ile Pro Gly Leu Asn Ser
                 965                 970                 975    
 Ser Thr Asp Val Gln Ala Arg Ile Asn Ala Gly Glu Ser Ile His Ile
             980                 985                 990        
 Ile Arg Gly Thr Lys Gly Thr Tyr Ile Arg Thr Ser Asp Gly Arg Ile
         995                1000                1005            
 Phe Ala Val Arg Ala Thr Gly Lys Pro Lys Val Pro Glu Asp Gly Arg
    1010                1015                1020                
 Met Ala Ala Ser Gly Ser Gln Gly Pro Ser Cys Glu Ser Thr Ser Asn
1025                1030                1035                1040
 Gly Arg His Ser Ala Ser Ser Pro Lys Ala Pro Asp Pro Glu Gly Leu
                1045                1050                1055    
 Ala Arg Pro Val Ser Pro Asp Ser Pro Glu Ile Ile Ser Glu Leu Gln
            1060                1065                1070        
 Gln Tyr Ala Asp Val Ala Ala Ala Arg Glu Ser Arg Gln Ser Ser Pro
        1075                1080                1085            
 Ser Thr Asn Ala Ala Leu Pro Gly Pro Pro Ala Gln Leu Met Asp Ser
    1090                1095                1100                
 Ser Ala Val Pro Gly Thr Ala Leu Gly Thr Glu Pro Arg Leu Gly Gly
1105                1110                1115                1120
 His Cys Leu Asn Ser Ser Leu Leu Val Thr Gly Gln Pro Cys Gly Asp
                1125                1130                1135    
 Arg His Pro Val Leu Asp Leu Arg Gly His Lys Arg Lys Leu Ala Thr
            1140                1145                1150        
 Pro Pro Ala Ala Gln Glu Ser Ser Arg Arg Arg Ser Arg Lys Gly His
        1155                1160                1165            
 Leu Pro Ala Pro Val Gln Pro Tyr Glu His Gly Tyr Pro Val Ser Gly
    1170                1175                1180                
 Gly Phe Ala Met Pro Pro Val Ser Leu Asn His Asn Leu Thr Thr Pro
1185                1190                1195                1200
 Phe Thr Ser Gln Ala Gly Glu Asn Ser Leu Phe Met Gly Ser Thr Pro
                1205                1210                1215    
 Ser Tyr Tyr Gln Leu Ser Asn Leu Leu Ala Asp Ala Arg Leu Val Phe
            1220                1225                1230        
 Pro Val Thr Thr Asp Pro Leu Val Pro Ala Gly Pro Val Ser Ser Ser
        1235                1240                1245            
 Ser Thr Ala Thr Ser Val Thr Ala Ser Asn Pro Ser Phe Met Leu Asn
    1250                1255                1260                
 Pro Ser Val Pro Gly Ile Leu Pro Ser Tyr Ser Leu Pro Phe Ser Gln
1265                1270                1275                1280
 Pro Leu Leu Ser Glu Pro Arg Met Phe Ala Pro Phe Pro Ser Pro Val
                1285                1290                1295    
 Leu Pro Ser Asn Leu Ser Arg Gly Met Ser Ile Tyr Pro Gly Tyr Met
            1300                1305                1310        
 Ser Pro His Ala Gly Tyr Pro Ala Gly Gly Leu Leu Arg Ser Gln Val
        1315                1320                1325            
 Pro Pro Phe Asp Ser His Glu Val Ala Glu Val Gly Phe Ser Ser Asn
    1330                1335                1340                
 Asp Asp Glu Asp Lys Asp Asp Asp Val Ile Glu Val Thr Gly Lys
1345                1350                1355                



      <210> 429
      <211> 224
      <212> PRT
      <213> Homo sapiens


      <400> 429
 Met Gly Leu Arg Asp Trp Leu Arg Thr Val Cys Cys Cys Cys Arg Cys
   1               5                  10                  15    
 Glu Cys Leu Glu Glu Arg Ala Leu Pro Glu Lys Glu Pro Leu Val Ser
              20                  25                  30        
 Asp Asn Asn Pro Tyr Ser Ser Phe Gly Ala Thr Leu Val Arg Asp Asp
          35                  40                  45            
 Glu Lys Asn Leu Trp Ser Met Pro His Asp Val Ser His Thr Glu Ala
      50                  55                  60                
 Asp Asp Asp Arg Thr Leu Tyr Asn Leu Ile Val Ile Arg Asn Gln Gln
  65                  70                  75                  80
 Ala Lys Asp Ser Glu Glu Trp Gln Lys Leu Asn Tyr Asp Ile His Thr
                  85                  90                  95    
 Leu Arg Gln Val Arg Arg Glu Val Arg Asn Arg Trp Lys Cys Ile Leu
             100                 105                 110        
 Glu Asp Leu Gly Phe Gln Lys Glu Ala Asp Ser Leu Leu Ser Val Thr
         115                 120                 125            
 Lys Leu Ser Thr Ile Ser Asp Ser Lys Asn Thr Arg Lys Ala Arg Glu
     130                 135                 140                
 Met Leu Leu Lys Leu Ala Glu Glu Thr Ser Ile Phe Pro Thr Ser Trp
 145                 150                 155                 160
 Glu Leu Ser Glu Arg Tyr Leu Phe Val Val Asp Arg Leu Ile Ala Leu
                 165                 170                 175    
 Asp Ala Ala Glu Glu Phe Phe Lys Leu Ala Arg Arg Thr Tyr Pro Lys
             180                 185                 190        
 Lys Pro Gly Val Pro Cys Leu Ala Asp Gly Gln Lys Glu Leu His Leu
         195                 200                 205            
 Trp Gly Asp Leu Ser Cys Arg Leu Ala His Met Gln Gly Val Leu His
     210                 215                 220                





      <210> 430
      <211> 497
      <212> PRT
      <213> Homo sapiens


      <400> 430
 Met Ala Asp Pro Glu Val Val Val Ser Ser Cys Ser Ser His Glu Glu
   1               5                  10                  15    
 Glu Asn Arg Cys Asn Phe Asn Gln Gln Thr Ser Pro Ser Glu Glu Leu
              20                  25                  30        
 Leu Leu Glu Asp Gln Met Arg Arg Lys Leu Lys Phe Phe Phe Met Asn
          35                  40                  45            
 Pro Cys Glu Lys Phe Trp Ala Arg Gly Arg Lys Pro Trp Lys Leu Ala
      50                  55                  60                
 Ile Gln Ile Leu Lys Ile Ala Met Val Thr Ile Gln Tyr Leu Gln Leu
  65                  70                  75                  80
 Tyr Asn Val Ser Val Gly Asn His Ala Tyr Glu Asn Lys Gly Thr Lys
                  85                  90                  95    
 Gln Ser Ala Met Ala Ile Cys Gln His Phe Tyr Lys Arg Gly Asn Ile
             100                 105                 110        
 Tyr Pro Gly Asn Asp Thr Phe Asp Ile Asp Pro Glu Ile Glu Thr Glu
         115                 120                 125            
 Cys Phe Phe Val Glu Pro Asp Glu Pro Phe His Ile Gly Thr Pro Ala
     130                 135                 140                
 Glu Asn Lys Leu Asn Leu Thr Leu Asp Phe His Arg Leu Leu Thr Val
 145                 150                 155                 160
 Glu Leu Gln Phe Lys Leu Lys Ala Ile Asn Leu Gln Thr Val Arg His
                 165                 170                 175    
 Gln Glu Leu Pro Asp Cys Tyr Asp Phe Thr Leu Thr Ile Thr Phe Asp
             180                 185                 190        
 Asn Lys Ala His Ser Gly Arg Ile Lys Ile Ser Leu Asp Asn Asp Ile
         195                 200                 205            
 Ser Ile Arg Glu Cys Lys Asp Trp His Val Ser Gly Ser Ile Gln Lys
     210                 215                 220                
 Asn Thr His Tyr Met Met Ile Phe Asp Ala Phe Val Ile Leu Thr Cys
 225                 230                 235                 240
 Leu Val Ser Leu Ile Leu Cys Ile Arg Ser Val Ile Arg Gly Leu Gln
                 245                 250                 255    
 Leu Gln Gln Glu Phe Val Asn Phe Phe Leu Leu His Tyr Lys Lys Glu
             260                 265                 270        
 Val Ser Val Ser Asp Gln Met Glu Phe Val Asn Gly Trp Tyr Ile Met
         275                 280                 285            
 Ile Ile Ile Ser Asp Ile Leu Thr Ile Ile Gly Ser Ile Leu Lys Met
     290                 295                 300                
 Glu Ile Gln Ala Lys Ser Leu Thr Ser Tyr Asp Val Cys Ser Ile Leu
 305                 310                 315                 320
 Leu Gly Thr Ser Thr Met Leu Val Trp Leu Gly Val Ile Arg Tyr Leu
                 325                 330                 335    
 Gly Phe Phe Ala Lys Tyr Asn Leu Leu Ile Leu Thr Leu Gln Ala Ala
             340                 345                 350        
 Leu Pro Asn Val Ile Arg Phe Cys Cys Cys Ala Ala Met Ile Tyr Leu
         355                 360                 365            
 Gly Tyr Cys Phe Cys Gly Trp Ile Val Leu Gly Pro Tyr His Asp Lys
     370                 375                 380                
 Phe Arg Ser Leu Asn Met Val Ser Glu Cys Leu Phe Ser Leu Ile Asn
 385                 390                 395                 400
 Gly Asp Asp Met Phe Ala Thr Phe Ala Lys Met Gln Gln Lys Ser Tyr
                 405                 410                 415    
 Leu Val Trp Leu Phe Ser Arg Ile Tyr Leu Tyr Ser Phe Ile Ser Leu
             420                 425                 430        
 Phe Ile Tyr Met Ile Leu Ser Leu Phe Ile Ala Leu Ile Thr Asp Thr
         435                 440                 445            
 Tyr Glu Thr Ile Lys Gln Tyr Gln Gln Asp Gly Phe Pro Glu Thr Glu
     450                 455                 460                
 Leu Arg Thr Phe Ile Ser Glu Cys Lys Asp Leu Pro Asn Ser Gly Lys
 465                 470                 475                 480
 Tyr Arg Leu Glu Asp Asp Pro Pro Val Ser Leu Phe Cys Cys Cys Lys
                 485                 490                 495    
 Lys
    



      <210> 431
      <211> 183
      <212> PRT
      <213> Homo sapiens


      <400> 431
 Met Ala Thr Pro Arg Pro Cys Ala Asp Gly Pro Cys Cys Ser His Pro
   1               5                  10                  15    
 Ser Ala Val Leu Gly Val Gln Gln Thr Leu Glu Glu Met Asp Phe Glu
              20                  25                  30        
 Arg Gly Ile Trp Ser Ala Ala Leu Asn Gly Asp Leu Gly Arg Val Lys
          35                  40                  45            
 His Leu Ile Gln Lys Ala Glu Asp Pro Ser Gln Pro Asp Ser Ala Gly
      50                  55                  60                
 Tyr Thr Ala Leu His Tyr Ala Ser Arg Asn Gly His Tyr Ala Val Cys
  65                  70                  75                  80
 Gln Phe Leu Leu Glu Ser Gly Ala Lys Cys Asp Ala Gln Thr His Gly
                  85                  90                  95    
 Gly Ala Thr Ala Leu His Arg Ala Ser Tyr Cys Gly His Thr Glu Ile
             100                 105                 110        
 Ala Arg Leu Leu Leu Ser His Gly Ser Asn Pro Arg Val Val Asp Asp
         115                 120                 125            
 Asp Gly Met Thr Ser Leu His Lys Ala Ala Glu Arg Gly His Gly Asp
     130                 135                 140                
 Ile Cys Ser Leu Leu Leu Gln His Ser Pro Ala Leu Lys Ala Ile Arg
 145                 150                 155                 160
 Asp Arg Lys Ala Arg Leu Ala Cys Asp Leu Leu Pro Cys Asn Ser Asp
                 165                 170                 175    
 Leu Arg Asp Leu Leu Ser Ser
             180            



      <210> 432
      <211> 115
      <212> PRT
      <213> Homo sapiens


      <400> 432
 Met Ala Thr Pro Arg Pro Cys Ala Asp Gly Pro Cys Cys Ser His Pro
   1               5                  10                  15    
 Ser Ala Val Leu Gly Val Gln Gln Thr Leu Glu Glu Met Asp Phe Glu
              20                  25                  30        
 Arg Gly Ile Trp Ser Ala Ala Leu Asn Gly Asp Leu Gly Arg Val Lys
          35                  40                  45            
 His Leu Ile Gln Lys Ala Glu Asp Pro Ser Gln Pro Asp Ser Ala Gly
      50                  55                  60                
 Tyr Thr Ala Leu Ala Ala Glu Arg Gly His Gly Asp Ile Cys Ser Leu
  65                  70                  75                  80
 Leu Leu Gln His Ser Pro Ala Leu Lys Ala Ile Arg Asp Arg Lys Ala
                  85                  90                  95    
 Arg Leu Ala Cys Asp Leu Leu Pro Cys Asn Ser Asp Leu Arg Asp Leu
             100                 105                 110        
 Leu Ser Ser
         115



      <210> 433
      <211> 282
      <212> DNA
      <213> Homo sapiens


      <400> 433
 aggcagctcc tggagcagag tcggcactct tgggttaaca ccacggtact catcacaggc     60
 tgcaccaacg ctgcgggcct cttggtggtt ggcaactttc agcctcgttt taggtggagt    120
 cttctttgtc catgagagtt ctcagctgca acatggggca gccctgtgtg agtgggtgtg    180
 tgtcatcgat atcctcattt tctatggcac cttcagctac gagtttgggg cagtctcctc    240
 agacacactg gtggctgcac tgcacttagc ccctgggccg gg                       282



      <210> 434
      <211> 381
      <212> DNA
      <213> Homo sapiens


      <400> 434
 acattgcagc aggcagagta tgaatttctg tcctttgtac gacagcagac tcctccaggg     60
 ctctgtccac ttgcaggaaa ttcagttcat gaagataaga agtttcttga caaatacatg    120
 ccccagttca tgaaacatct tcattataga ataattgatg tgagcactgt taaagaactg    180
 tgcagacgct ggtatccaga ttgattactc aagcagacag cacacgaaat actatttttc    240
 tcctaatatg ctgtttccat tatgacacag cagctccttt gtaagtacca ggtcatgtcc    300
 atcccttggt acatatatgc atttgctttt aaaccatttc ttttgtttaa ataaataaat    360
 aagtaaataa agctaaaaaa a                                              381



      <210> 435
      <211> 484
      <212> DNA
      <213> Homo sapiens


      <400> 435
 agcagctgcc atggatggat tttgggggaa catggcgact caagtgtggc tgtgtggagt     60
 ggtgtgaatg tggcaggtgt ttctctccag gaattgaatc cagaaatggg aactgccaat    120
 gatagtgaaa attggaagga agtgcataag atggtggttg aaagtgccta tgaagtcatc    180
 aagctaaaag gatataccaa ctgggctatt ggattaacca gcgttatcaa ccagaagcta    240
 aaggatgatg aggttgctca gctcaagaaa agtgcagata ccctgtggga cataggctgt    300
 agaaatttaa aaactacaat gtgattaact cgagccttta gttttcatcc atgtacatgg    360
 atcacagttt gctttgatct tcttcaatat gtgaatttgg gctcacagaa tcaaagccta    420
 tgcttggttt aatgcttgca atctgagctc ttgaacaaat aaaattaact attgtagtgt    480
 gaaa                                                                 484



      <210> 436
      <211> 607
      <212> DNA
      <213> Homo sapiens


      <400> 436
 gaagaacatg tcctttgtga atgatcttac agtcactcag gatgggagga agatttattt     60
 caccgattct agcagcaaat ggcaaagacg agactacctg cttctggtga tggagggcac    120
 agatgacggg cgcctgctgg agtatgatac tgtgaccagg gaagtaaaag ttttattgga    180
 ccagctgcgg ttcccgaatg gagtccagct gtctcctgca gaagactttg tcctggtggc    240
 agaaacaacc atggccagga tacgaagctc tttagtcaag agacggtgat gaagtttgtg    300
 ccgcggtaca gcctcgtcct agaactcagc gacagcggtg ccttccggag aagcctgcat    360
 gatcccgatg ggctggtggc cacctacatc agcgaagtgc acgaacacga tgggcacctg    420
 tacctgggct ctttcaggtc ccccttcctc tgcagactca gcctccaagc tgtttagccc    480
 tcccagatag ctgcccctgc cacgcaggcc aggagtcttc acactcaggc accaggcctg    540
 gtccaggagg agctgtggac acagtcgtgg ttcaagtgta cacatgcacc tgttagtccc    600
 tgagagg                                                              607



      <210> 437
      <211> 2423
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2423)
      <223> n = a,t,c or g


      <400> 437
 ctcatcatta ctccaagctt ggcacgaggg tctcattcat gcccagatga aggccaatgc     60
 cacgcagcct aaaggggttg tctctggtct cctacctata cccacctttc agtgtgtctg    120
 cctagaagga aatgagtaat gacctctcac agtccctcag gttaccctca ctgtctacac    180
 cttactcctc ttctgtatgc ttaacaccat ctcaccaaac cagggcctac tttatgttcc    240
 tagcagtagc tcacaggggt atggtgtgtt tgtgtaactt ttcagcacct tctctttttc    300
 ctttcaatga tgcagggcaa ttctgcacag acttacaaac tgtgcatgta aaagtgtaaa    360
 agcatgtatc ctcttattgt agtcttaaaa agctcgtgga atctagggac acagaagatt    420
 ctgtggcaca gatttaggta cagagcaaaa tactcactgg aaaaatcaag tattggctag    480
 ctaccacggg gatttgatcc tagctggcaa acgtggaact ccgcaaatac ttggagccat    540
 taattatgta tacttgtttt attcataatt tgtcatgttc tgggatacca aaagtaataa    600
 tggctgaact taacaaaatt tgtaacctca tcttaatatc cactgatcca tctcattcaa    660
 tggtaacagt caatgttttc taaaaggaac ataaaaacca acatgcacac aattgcacag    720
 ttttcataaa ggtctatttc attattggtg ggtagcggca tttaaccagt taaatacatt    780
 taaataatgt ataggtgact gcaggactgc agcaattggt atactagata accaactaga    840
 aaccagctaa caaagaactg gtctaaatac ttaaaataca gctcttggtt gagatcatcc    900
 tttggttttg gatcaacctt cctggggggg aaaaaagcct gctggctggg tcacaatggg    960
 aaatattatt aagggccaaa tcttctgata tcccattccc aaaaggtttc ctttcagctg   1020
 ggattaagcc tccaacttcc aggggggagc caacccttgt gggcctccag cattaaatgc   1080
 tcttcccatc taccagaggc agaggagtgt aagttttcac accagggcct caggagtttt   1140
 gagtattagc ctacttccaa ttaaggctag aaagtgttga cttttgcaga aaatggaagc   1200
 cagtgggatc caacttgata ttttaggcgc aatgcccaaa acgagtgcca gttgggtacc   1260
 ctgatgtccc aagcaaaggt ttacttgaag tgtccaagat cttcacaaac tttctggata   1320
 aattgatccc tccaaattct gtcccatcat tgacatttgt ggtgtagctg gaaagtcccc   1380
 agtcctgtaa gcccactgca aagttattcc ttgtcagctt tgatttggca ctgtcaaagg   1440
 tcatctggta gccagcaagc cagccctcat aaccaaagac agctgaacca tggattgcag   1500
 gtccagcaaa atcaaagtca acatcacaac caatggttta tacactccct cttgtaagaa   1560
 gacttgaatt ttaccacttt tctttcctgt gtttgggtga gaaaggtagt atccaatgtc   1620
 cagtttcaaa cccttgaaca aatctggtcc ttcaaattgc cgatttcctg ttccccagaa   1680
 tgttaatcca gtgttcccac tttttctgtg aaaagtcaga ccatactcaa caccacttgt   1740
 aatttggtct cccaaggtcc ccagtaactt taccaagtgt cttgtattag atgaaccgga   1800
 cggttgaaaa ttccacgcca ctgcaagact ttgttttcac atccagtttc accaacccaa   1860
 aaccaaatcc tttgttgaaa atatctctgg cagctttgcc aaggtcagca tatgatggag   1920
 gaatacacat tggacgcgcg caagtctgtc cgtgggtcgc catggcgagg ccgcgggcgg   1980
 aacggtgtct ccttcacttc gccctccagc tgctgcagct gcagcccgac cgcgagcgtg   2040
 ccaagcggct tcagcagcta gcggagcggt ggcggcggcc cccctcagga caccaccaga   2100
 ttcccctctt cccgcggcct cgccatggcg acccacggac agacttgcgc gcgtccaatg   2160
 tgtattcctc catcatatgc tgaccttggc aaagctgcca gagatatttt caacaaagga   2220
 tttggttttg gcgtggtgaa anctgatgtg aaaacaaagt cttgcagtgg cgtggaattt   2280
 tcaacgtccg ggtcatctaa tacagacact tggtaagcta ctgggacctt ggagaccata   2340
 tacctgaggt gcgagcattg gcagactttc acagacttgg gcaacactga ttgcactttg   2400
 ggaaatgatg tggaattgga gac                                           2423



      <210> 438
      <211> 3411
      <212> DNA
      <213> Homo sapiens


      <400> 438
 atgaaactca tggaaacact taaccagtgc ataaacgctg gtcatgaaat gacgaaggct     60
 atcgccattg cacagtttaa tgatgacagc ccggaagcga ggaaaataac ccggcgctgg    120
 agaataggtg aagcagcgga tttagttggg gtttcttctc aggctatcag agatgccgag    180
 aaagcagggc gactaccgca cccggatatg gaaattcgag gacgggttga gcaacgtgtt    240
 ggttatacaa ttgaacaaat taatcatatg cgtgatgtgt ttggtacgcg attgcgacgt    300
 gctgaagacg tatttccacc ggtgatcggg gttgctgccc ataaaggtgg cgtttacaaa    360
 acctcagttt ctgttcatct tgctcaggat ctggctctga aggggctacg tgttttgctc    420
 gtggaaggta acgaccccca gggaacagcc tcaatgtatc acggatgggt accagatctt    480
 catattcatg cagaagacac tctcctgcct ttctatcttg gggaaaagga cgatgtcact    540
 tatgcaataa agcccacttg ctggccgggg cttgacatta ttccttcctg tctggctctg    600
 caccgtattg aaactgagtt aatgggcaaa tttgatgaag gtaaactgcc caccgatcca    660
 cacctgatgc tccgactggc cattgaaact gttgctcatg actatgatgt catagttatt    720
 gacagcgcgc ctaacctggg tatcggcacg attaatgtcg tatgtgctgc tgatgtgctg    780
 attgttccca cgcctgctga gttgtttgac tacacctccg cactgcagtt tttcgatatg    840
 cttcgtgatc tgctcaagaa cgttgatctt aaagggttcg agcctgatag tgcccacgac    900
 cctccggctg tccacctcag caatggccca ggacaagagc ctatcgctgt catgaccttt    960
 gacctcacca agatcacaaa aacctcctcc tcctttgagg ttcgaacctg ggacccagag   1020
 ggagtgattt tttatgggga taccaaccct aaggatgact ggtttatgct gggacttcga   1080
 gacggcaggc ctgagatcca actgcacaat cactgggccc agcttacggt gggtgctgga   1140
 ccacggctgg atgatgggag atggcaccag gtggaagtca agatggaggg ggactctgtg   1200
 ctgctggagg tggatgggga ggaggtgctg cgcctgagac aggtctctgg gcccctgacc   1260
 agcaaacgcc atcccatcat gaggattgcg cttggggggc tgctcttccc cgcttccaac   1320
 cttcggttgc cgctggttcc tgccctggat ggctgcctgc gccgggattc ctggctggac   1380
 aaacaggccg agatctcagc atctgccccc actagcctca gaagctgtga tgtagaatca   1440
 aatcccggga tatttctccc tccagggact caggcagaat tcaatctccg aggctcttca   1500
 ggatccaagt ccgtaggccc tttaaggggt ctagttgccg tttgcgaggc cctgggactt   1560
 tggtcccaga cagcggggat ccggatggct tccgtgcgga tccgagaggc caaggaggga   1620
 gactgtggag atatcctgag gctgattcgg gagctagccg aattcgaaaa actctcggat   1680
 caggtgaaga tcagtgaaga agggccctgc gtggtgggct atgggatata ctatttcatc   1740
 tacagtacat ggaagggacg caccatttat ctggaggata tctatgtgat gccagaatat   1800
 cggggtcaag ggattggttc caaaataatc aaaaaggtgg ctgaggtggc cttggataag   1860
 ggctgctccc aattccgcct ggccgtcctg gactggaacc agagggccat ggacttgtac   1920
 aaggccctag gagcccaaga tctgacggaa gctgagggct ggcacttctt ctgctttcaa   1980
 ggagaggcaa cgagaaagtt ggcaggaaac tggcagagtg agagacaaat tccttttggg   2040
 gatgtccggc taccacctcc agctgactat aataaggaga tcacagaagg ggatgaagtg   2100
 gaggtttatt ctcgagccaa tgaacaggaa ccttgtggct ggtggctggc ccgggtgcgg   2160
 atgatgaagg gagataaagt tgctcaggtc atccacaact tctccttttt taccatgtgc   2220
 cagttctatg tcattgaata tgctgcctgt gatgccacct acaatgaaat tgttaccctg   2280
 gagcgacttc ggccagttaa tcccaatccc cttgcaacca aaggcagctt cttcaaggtt   2340
 accatggctg tgcccgagga tctgagagaa gcctgctcca atgaaaacgt ccataaagag   2400
 ttcaagaaag ccctgggagc caactgcatc tttctcaaca tcacaaacag tgagctcttc   2460
 attctgtcaa ccacagaagc ccctgtgaag cgagcatctc tgctgggtga tatgcatttc   2520
 cgaagcctgc gcaccaaact gctacttatg tcccgcaatg aagaagctac caagcaccta   2580
 gagaattgta ttcgtgtgcg taatattgaa acaaaactcg tcactggaaa agtaggtact   2640
 caaaacacac aactgcttgg taatacgctt actggaagca ctgccgccaa aggcgttggc   2700
 gtactcattg aaggtttagc aaccagtaaa aatccgctaa tgacattaaa acctaatgat   2760
 acgaattctg tttatataga ttatgaaacc gaagatgaca cctccgatgg ggtttaccct   2820
 aatcaaggta acgtcacatc acagcctctt catttccagg caacattaaa gcaagacggg   2880
 aatattgcta tcgaacccgg cgaatttaaa gccaccagta ctttccaggc agaggccaag   2940
 ctgccctcga aacatccaat ctgctccaag ttcagaggca gcctccagcg catgggaaga   3000
 ggctattgga ttcagctgtt cttcagccca cccgttcatc ctgactatgg gaaacaagaa   3060
 gctaaagcag acttatcttt cagttttgtg gcaaatgagg tactgagtga aaggagagaa   3120
 gccttcatct ccatagattc agaagaggga gcattgctag aagacaatgg catgctcttg   3180
 gctcactgga tcatctacgt ctcggagata tgcgattatt gtaacttacg cttccaggga   3240
 tctagcgtta caggaatgat cagcatggac ggttcttatt gctttgacat tcatgtttca   3300
 tctagtgaac ttttctcatc tgtcacggag catttgctga ggaccttttc atctcatatc   3360
 atccctcgtt tagagtgccg ttcagatgct actacctcag agaaagattg a            3411



      <210> 439
      <211> 518
      <212> DNA
      <213> Homo sapiens


      <400> 439
 tgacactgct gaggtctaaa caaggaggca gaagtagtct tcagttcacg atcttctagt     60
 tgcagcgatg agtgccacga gtgagattca agatcccaga ggaagaggag atggtccagg    120
 aggcctcccc gatgtggttg ccattccgtg gcctccccgg tgaatcctca gccaagagga    180
 acccacccaa ctgacaatca ggatattgaa ccctggacaa gagagagaag gaacacctcc    240
 gatcgaagaa cgtaaagtag aaggtgattg cccaggaaat ggatctggga aaagactcgg    300
 agtgagcgtg ggagatggct ctgatgtaaa agagaagact cccacctaaa tccttaagca    360
 tgctaagact aaagaagcag gagatgggca gccataagtt aaaaagaaga ccaactgaag    420
 ctacacacat ggctgatgtc acattgaaaa tgtgacttga aaattttgaa aattctctcc    480
 aataaagttt gagttttctc tgaagaaaaa aaaaaaaa                            518



      <210> 440
      <211> 631
      <212> DNA
      <213> Homo sapiens


      <400> 440
 cctatgttga gtgcctatgt ttagggtatt atctagacat tagtggtaca tataagcata     60
 attaatccaa ggttcctact ttaattatat gtgaggtaag tagcatcttg attagtcctg    120
 atgttatttc attatatatc atggtcaatt taattttaga attatacatc tgaagagagg    180
 ggaagttttc aaagtggttt tattagcatg ttatttaaca taataaagta ttaatgtaat    240
 atttatggat atatttaaag aaatgaatga cttttaacga gattttctcc cctctctctc    300
 tctcattagg ttcttggagt gtcaatgttt taataccagt acacaattaa atctgtggtg    360
 aagtcatttt ctaagtggaa gaggaaattt taaagtgtgg tagatacagt gaaattctgt    420
 acagattttt ctctaaggag aatatgacat gcttatgctt accaagatca agtgcattga    480
 ggggcagttt tgtttgcctg aataaacgta aaggacaagt aaacaatttg atgataagct    540
 acagtttttc ttagaaagta aatattttat ttatgcgctg ttagttggct tttgaatcga    600
 ttatttcatg ctttttttta aaaaaaaaaa a                                   631



      <210> 441
      <211> 952
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(952)
      <223> n = a,t,c or g


      <400> 441
 caacacaggg gcagtctcca ggacctccac accattaaca agatgagcct tgtgctccct     60
 tgggctctag agaggaagcc cctctgagcc ctcagcccct ctttcctccc tctcctaaag    120
 taatttgatc ctcaggaatt tgttctgccc tcatctggcc ctggccagct ctgcatttga    180
 caaatgccag gaagaggaaa ctgttgagaa aacggaacta ctggggaaag ggagggctca    240
 ctgagaaccc atcccggtta cccccgatca ccgcttggtc accatgaccc acattgttgc    300
 aaaccttttc tcctgtcaac agccggccag cctcccaatt acgagatgct caaggaggag    360
 caggaagtgg ctaagcctgg gggcgcccca aaaaccgtgc ttacccgaat gtccacgcgt    420
 gatcaacatc cgcaacgaga acctcgtggc ctgaccatgt tcgtctggtc cctgttcaaa    480
 caccctcttc atgaacacct gcttngcctg ggcttcataa gattcgccct actccgtgaa    540
 aagtctaagg gacaggaaag atggttggcg acgtgaaccg gggccccaag gcctaatgcc    600
 tccaccgcca aagtgcctga aaaatctggg ccctgatttt gggcatcttc aatgaccatt    660
 tttgctcatc aatcatcccc agttttgggt cgtcccaggc ccagcgatag atcaggaggc    720
 atcattgagg cccaggagct ctgcccgtga cctgtatccc acgtactcta tcttccattc    780
 ctcgccctgc ccccagaggc caggaagctt tgcccttgac ctgtattcca cttactccac    840
 cttccattcc tcgccctgtc cccacagccg agtcctgcat cagcccttta tcctcacacg    900
 cttttctaca atggcattca ataaagtgta tatgtttctg gtgcaaaaaa aa            952



      <210> 442
      <211> 1938
      <212> DNA
      <213> Homo sapiens


      <400> 442
 gcggccgcag tggcgtcctg gagccctcct caggtgagct ggagctgccc ggctcggcag     60
 cgggaagtgc tgaagctgct gaaagatggc agaagaagtg gtggtagtag ccaaatttga    120
 ttatgtggcc caacaagaac aagagttgga catcaagaag aatgagagat tatggcttct    180
 ggatgattct aagtcctggt ggcgagttcg aaattccatg aataaaacag ggttttgtgc    240
 cttctaccta tgtgggaagg ggaaaacagt gctcggaaag catctattgt gaaaaaccta    300
 aaggatacct taggcattgg aaaagtgaaa agaaaaccta gtgtgccaga ttctgcatct    360
 cctgctgatg atagttttgt ttgacccagg ggaacgtctc tatggacctc aacatgcccg    420
 ctttatgtga aatttaactt acatggctga gagagaggat gaattatcat ttgataaagg    480
 gggacaaagg tgatcgtcat ggagaaatgc agtggatggt tggtggcgtg gtacctacaa    540
 tggacaagtt ggatggttcc cttcaaacta tgtaactgaa gaaagtgaca cgtcctttgg    600
 gtgaccatgt gggttctctg tcagagaaat tagcagcagt cgtcaataac ctaaatactg    660
 ggcaagtgtt gcatgtggta caggctcttt acccattcag ctcatctaat gatgaagaac    720
 ttaatttcga gaaaaggaga tgtaatggat gttattgaaa aacctgaaaa tgacccagag    780
 tggtggaaat gcaggaagat caatggtatg gttggtctag taccacaaaa actatggtaa    840
 ccgctattgc agagtattca attaacctca ggtttgggaa ccttaacctt ccagtgtgga    900
 ttcattaggc cttacattcc tggaaagttt gttggcaatc cttggtatta tggcaaagtc    960
 accaggcatc aagcagaaat ggcattaaat gaaagaggac atgaagggga tttcctcatt   1020
 cgtgatagtg aatcttcgcc aaatgatttc tcagtatcac taaaagcaca agggaaaaac   1080
 aagcatttta aagtccaact aaaagatgac tgtctactgc atttggcagc gtaaatcatg   1140
 caccatggaa tgacttgtag aacattacaa aaacggcacc aaatttttac aacgtgaaca   1200
 aaggagaaaa attatatctt gtcaagcatt tatccatgat actgctgacc cagaagtgac   1260
 tgctgtgtag ctgtaatttg tcatgtaatt gaattgaaga ctgagaaaat gttgggtcca   1320
 gtcgtgcttg attgggaaat tggttgtttc taaatccata tggagaattt gaccattaag   1380
 tatttttatt ataactcagc ccatacatat atactatgta tgcagtgcat ctgcatagaa   1440
 cagttcctta tccttggcct tctgttttat ggtttttttc tttgctgttt tcccccttgg   1500
 cttctaatat tacagttttg tattttgtaa acaaaaaatc aaataatggc atatcagaat   1560
 ctttatatgg aagaaatcct ttattgccct ttcctttgtt tccttgtaaa ggcaccctgt   1620
 tctgttatgg tttttcatta tataaaatta ttatatctat atatgacata tgctaaaatt   1680
 tcttggagag tgttaatctt ttctgtgact aaatagcaat aataagtgga aaattagaaa   1740
 ttatttccag gtattatatt tgtcacaggc cattgtaaat accaagtata ttgtgtctgc   1800
 cataattttt aaaaatacat tcattgtctt cagtcataca gcaagacaca tgagacatag   1860
 attagaaaac atgttgtaca attttaattt acaactgttg aaaataacac accccttaat   1920
 ttttttccaa aaaaaaaa                                                 1938



      <210> 443
      <211> 414
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(414)
      <223> n = a,t,c or g


      <400> 443
 gggtggtggg gcttctggac tgagccgctg agggtgcggg ctgaccctgt aagtggctgc     60
 ggcgggaaga tggcggagct gcgcgtgctc gtagctgtca agagggtcat cgactacgcc    120
 gtgaagatcc gagtgaagcc tgacagctga cctgaggctc aacgagcccc gctacgccac    180
 gctgcccaac atcatgaaag ccaagaagaa gaagatcgag gtgatcaagc ctggggacct    240
 gggtgtggac ctgacctcca agctctctgt gatcagtgtg gaggacccgc cccagcgcac    300
 ggccggcgtc aaggtggaga ccactgagga cctggtggcc aagctgaagg agattgggcg    360
 gatttgagcc cctcccagag atggcaataa aactgactct caacatcaaa aaan          414



      <210> 444
      <211> 2035
      <212> DNA
      <213> Homo sapiens


      <400> 444
 atttaattac cggaacgacc cacgcgtccg aggctgcata tagaccctgg gccggggctc     60
 gcgctggccg gctgcagcgc gcaaggtgcc aagccctccc ctacgaagtc tgttttgtct    120
 caggctgggc tgagtcacat agaatagata gatagttgat ttagcacatg tcctccagat    180
 catattatcc gcctacaaat atagcctgtt agcgcacagg cacgggaggc ttcttccggc    240
 tcggccgtgc tgctcagcgg gtgtataaca gcctctgcgg tgtaaacagc actctgcggt    300
 gtaaacagcc gcgttggcca ggccaggact gtcagtgccc gcccctcggg gcaggtaatt    360
 tcatgctccc aaaatgggac ataaagtggt tgtcttcgac atttctgtca tcagagcctt    420
 gtgggaaact cgtgtcaaga agcacaaagc ttggcagaag aaggaggtgg aaaggcttga    480
 gaagagcgcc ttggagaaga tatatttagg agtggaactt tgtggccgaa tgcaggagga    540
 agggcttttt cccaggctgt atactgcttg aatggcttca tagacaccag cgtgcggctt    600
 ctggacaaga ttgaaaggaa cactctcaca aggcagagtt cacttcccaa ggacagaggc    660
 aaacggagca gagcgtttgt gtttgaactt tctggggagc actggacgga gctcccagat    720
 tcattgaagg agcagacaca cctgagagaa tggtacataa gcaatacctt gattcaaatc    780
 attcctacat atattcagtt atttcaagcg atgagaattc tggatctgcc aaaaaaccaa    840
 atctcacatc ttccagcaga aatcggttgt ttgaagaacc tgaaagaact caatgtgggt    900
 ttcaactatc tgaagagcat tcctccagaa ttgggagatt gtgaaaatct agagagactg    960
 gattgttctg gaaatctaaa attaatggag ctgccctttg aattaagtaa tttgaagcaa   1020
 gttacatttg tagatatctc agcaaacaag ttttccagtg tcccaatctg tgtcctgcgg   1080
 atgtcgaatt tgcagtggtt ggatattcac cgccataacc tggccgacct tgccgaagat   1140
 atagacaggc tagaggagct gcagagcttt ctcttgtata aaaacaagtt gacctacctt   1200
 ccctattcca tgctgaacct gaagaagctc actctgttag tcgtcagtgg ggaccatttg   1260
 gtggagctcc caactgccct ttgtgactca tccacacctt taaaatttgt aagccttatg   1320
 gacaatccta ttgataatgc ccaatgtgaa gatggcaatg aaataatgga aagtgaacgg   1380
 gatcgccaac attttgataa agaagttatg aaagcctata ttgaagtcct taaagaaaga   1440
 gaatctgttc ccagctatac caccaaagtg tcttttagcc ttcaactttg atatccatca   1500
 gaagactgca aatctcacta ttctctggag ctatatataa atctttgtta tgatcatgtc   1560
 atataggaag aatggcttgt gcttaaggac aaagtctaga aaccactatc atagttgcta   1620
 aaaaaaatgg ttttcaaatg tcaaatacat gagtatctcc ctccatggac tggagaattg   1680
 aaaaattggt ttgtatattg atatttccag gttcatttgc atatactttt ttccaaataa   1740
 tgcacattta atatgtttta aaatgtctta tttttaagaa ttataactaa aagaccaaat   1800
 actgaagtta agtgcattgt tttcaggaat caaaagataa aggggccggg tgtggtggct   1860
 cacacctgta atcccagcac tttgggaggc cgaagtgggt ggatcacctg aggtccggag   1920
 ttcgaggctg gtttggccag catggcgaaa ccccatctct actaaaaata caaaaaatta   1980
 gctgggcatg gtggcagttg cctgtaatcc tagctactca ggaggctgag gcagg        2035



      <210> 445
      <211> 809
      <212> DNA
      <213> Homo sapiens


      <400> 445
 cccccccccc ccccgccgct tctttctttc cgcgccgata gcgctcacgc aagcatgggt     60
 ttaacgtccc ctaaaacccc gccggacttt ctgtaagtaa gtgtggcaaa gcaccaaccc    120
 cccataaaag tgaccacagt accaagaagg gcaaggattc ctctgtacgc ccccagggaa    180
 aacggcgtta tgacaggaag cagagacggc tatggtggcc atactaagcc gattttccgg    240
 ataaaggcta aaactactga gaaaattgtg ctaaggcttg agtgcgttga gcccaacttg    300
 cagatctaag agaatgctgg ctattaaaag atggcaagca tttttgaact tgggaggaga    360
 taagaagaga aaggggccaa gtgcatccaa gttctaagtg ttcatctttt tatttattga    420
 agacaataaa aatcttgaag tttatgttca cttcatttgt ttgctgttca tcttttggga    480
 gggaataagc tagagccatc aatacaattc cgcttgtggg gaaatttatg cctcttactg    540
 gtactacttg ttttgcattg aagctgactg gttgagttca catcatatgt tgcaattttc    600
 taatttggca cttcaatcac taggggcctt atgaggcagt ttgtcattat gcaatggtta    660
 ttggttatca tgtgagtaga cacatttcag gctaataggg agaagtcagt aacacattca    720
 tagtgaatat gagatgtctt tgctaagagt taagtgtcag atctttgtta taacagttaa    780
 tttaataaag aattttggca ttgttcttc                                      809



      <210> 446
      <211> 1161
      <212> DNA
      <213> Homo sapiens


      <400> 446
 atggagctga aagccaaggc tcgagaacta cgtgaagaat gcagaagcct caggagccga     60
 tgcgatcaac tggaagaaag ggtatcagtg atggaaaatg aaatgaatga aatgaagcga    120
 gaagggaagt ttagagaaaa aagaataaaa agaaacgaac aaagccttca agaaatatgg    180
 gactatgtga aaagaccaaa tctacatctg attggtgtac ctgaaagtga cggggagaat    240
 ggaaccaagt tggaaaacac tctgcaggat attatccagg agaacttccc caatctagca    300
 aggcaggcca acattcagat tcaggaaata cagagaacgc cacaaagata ctcctcgaga    360
 agagcaactc caagacacat aattgtcaga atcaccaaag tggaaatgaa ggaaaaaatg    420
 ttaagggcag ccagagagaa aggtcgggtt ccccacaaag ggaagcccat cagactaaca    480
 gcggatctct cgtcagaaac tctacaagcc agaagagagt gggggccaat attcaacatt    540
 cttaaaagaa ttttcagctt tccacagcgc gggggaacgg gaggccgcag gatggtcaag    600
 ctgacggcgg agctgatcga gcaggcggcg cagtacacca gcgcggtgcg cgaccgggag    660
 ctggacctcc gggggtataa aattcccgtc attgaaaatc taggtgctac gttagaccag    720
 tttgatgcta ttgatttttc tgacaatgag atcaggaaac tggatggttt tcctttgttg    780
 agaagactga aaacgttgtt agtgaacaaa acagaatatg ccagtactgg atttccagaa    840
 agtgaaacta aagagcgtca ggaagcagag aaaatgttca agggcaaacg gggtgcacag    900
 cttgcaaagg atattgccag gagaagcaaa acttttaatc caggtgctgg tttgccaact    960
 gacaaaaaga aaggtgggcc atctccaggg gatgtagaag caatcaagaa tgctatagca   1020
 aatgcttcaa ctctggctga agtggagagg ctgaaggggt tgctgcagtc tggtcagatc   1080
 cctggcagag aacgcagatt ggggcccact gatgatggtg aagaagagat ggaagaagac   1140
 acagtcacaa acgggtcctg a                                             1161



      <210> 447
      <211> 352
      <212> DNA
      <213> Homo sapiens


      <400> 447
 cccttcaact tttgtagagc attccattta gttgcaagga aaaattaaat aaaaaaaata     60
 aaattggagc tgcctttact gatgatgctt tgccatgggt gtggcttaca ttctaaagct    120
 tttggatcag tatcgggagt ttgattcact tcactggttc cagtctgtta gagagaaata    180
 cctgaaggag ataagagcag ttgctaagca acagaatgta cagtcagcca gtcaagatga    240
 aaaactctta caaaccatga atctcactca gaagcgactg gatgtctatc tacagtgcaa    300
 gaattttctt cagagcagac aagactgcgg ctgaagaaaa ccaagaaaaa aa            352



      <210> 448
      <211> 1251
      <212> DNA
      <213> Homo sapiens


      <400> 448
 acagagcaag actccgtctc acacacaaaa aaatgaaaga ttggaatgcc acccctttcc     60
 tagcatgcac aacatatggc aggatcctgc tcttctgtcc cctgtagcgg gttgtcccgt    120
 gttcccctta aggaagaaat cacagttttt gtcctcctgg tgcttccggc tggaggttca    180
 cctgctagtc cctgatcctc tttgcttagt gatgcacatg agtctactca tccccccacc    240
 actcccagcc cccacttttt taagaataag aggtgatagg cagttcggcg gtcccgcggg    300
 tctgtctctt ggcttcaaca gtgtttggac ggaacagatc cgggggactc tcttcccagc    360
 ctccgaccgc cctccgattt ccctctccgc ttgcaaacct ccgggaccat cttctcggcc    420
 atcttcctgc attctgggac ctgccagcac cgtttttgtg gttagctctt tcttgccaac    480
 ccaaccatga gtctccagga ttcgtcagaa tatttccacc cgacgttgaa ggcaagcctg    540
 tctaacagcc ctggtcaaat ttgtacctgc agggcctccc accacctacc tctctctggg    600
 gtttctattt cgacccgcga tgatgtgggc tctggaaagg cgtgagccaa tttctttcgg    660
 cgaattgggc cgaggaagaa gcgccgaggg ctacgagcgt tcttcctgaa agatgcaaaa    720
 aaccagccgt gggcggcccg cgctcttctt ccaggacaat caagatagcc agcttgaaga    780
 tggagtgggg taaaaccccc cagacgccca tgaaaagctg ccatggccct ggaggaaaaa    840
 gcttgaacgc aggccctttt tggatctttc attgccctgg ggttcttgcc cgcacggacc    900
 cccatgctcc tgtgagcttc cctggagact cacttcccta gatgagggaa gtgaagctta    960
 tcaaagaaga tgggtgacca cctgagccaa cctccacagg gctgggtggc ccggaggctg   1020
 gggctggggc gaagtatctc ttcggaaagg ctcactctca agcacgacta agaagccttc   1080
 tgagcccagc gacttctgaa aaggcctctt gcaaagtaat acgggcttct gcctaagcct   1140
 ctccctacca gccaataggg aggctttctt aactattcct aacaaggcct tgggaccaaa   1200
 tgggaaataa agctttttga tggcaaaaaa aaacctcgtg gccgaattct t            1251



      <210> 449
      <211> 792
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(792)
      <223> n = a,t,c or g


      <400> 449
 ttcttttata agagcgtcct ggcccaaaag gaagttcgtt gtgtcctgga tgagtcagcc     60
 ctctcgggcc ccctgagctc aagnccgtgc gcatgtttgc tgatcttcgc cccacgagag    120
 tcggagggac agctccgtgc ccgagctggc cgagaagatg agcaggagcg tggacgtgcc    180
 cacaccacct tccctgctca tggcggcctc catctatctc cacgaccaga acccggatgc    240
 cgccctgcgt gcgctgcacc agggggacag cctggagtgc acagccatga caatgcagga    300
 tgcctactac atcttccagg agatggctga caagtgctcg cccaccctgc tgctgctcaa    360
 tgggcaggcg gcctgccaca tggcccaggg ccgctgggag gccgctgagg gcctgctgca    420
 ggaggcgcta gacaaggata gtggctaccc ggagacgctg gtcaacctca tcgtcctgtc    480
 ccagcacctg ggcaagcccc ctgaggtgac aaaccgatac ctgtcccagc tgaaggatgc    540
 ccacaggtcc catcccttca tcaaggagta ccaggccaag gagaacgact ttgacaggct    600
 ggtgctacag tacgctccca gcgcctgagg ctggcccaga gctgtcagga ccatgaagcc    660
 aggacagagg ccaggagcca gccctgcagc cctccccacc cggcatccac ctgcatcccc    720
 tctgggggca ggagcccacc cccagcaccc ccatctgtta ataaatatct caactccagg    780
 gtgttccacc tg                                                        792



      <210> 450
      <211> 12517
      <212> DNA
      <213> Homo sapiens


      <400> 450
 ctaccgggcg gaggtgagcg cggcgccggc tcctcctgcg gcggactttg ggtgcgactt     60
 gacgagcggt ggttcgacaa gtggccttgc gggccggatc gtcccagtgg aagagttgta    120
 aatttgcttc tggccttccc ctacggatta tacctggcct tcccctacgg attatactca    180
 acttactgtt tagaaaatgt ggcccacgag acgcctggtt actatcaaaa ggagcggggt    240
 cgacggtccc cactttcccc tgagcctcag cacctgcttg tttggaaggg gtattgaatg    300
 tgacatccgt atccagcttc ctgttgtgtc aaaacaacat tgcaaaattg aaatccatga    360
 gcaggaggca atattacata atttcagttc cacaaatcca acacaagtaa atgggtctgt    420
 tattgatgag cctgtacggc taaaacatgg agatgtaata actattattg atcgttcctt    480
 caggtatgaa aatgaaagtt cttcagaatg gaaggaagtc aactgaattt ccaagaaaaa    540
 tacgttgacc ggcgcccagc acgtcgtgtc tcaagatcta gcttctcttc tgaccctgat    600
 gagaaagctc aagattccaa ggcctattca aaaatcactg aaggaaaagt ttcaggaaat    660
 cctcaggtac atatcaagaa tgtcaaagaa gacagtaccg cagatgactc aaaagacagt    720
 gttgctcagg gaacaactaa tgttcattcc tcagaacatg ctggacgtaa tggcagaaat    780
 gcagctgatc ccatttctgg ggattttaaa gaaatttcca gcgttaaatt agtgagccgt    840
 tatggagaat tgaagtctgt tcccactaca caatgtcttg acaatagcaa aaaaaatgaa    900
 tctccctttt ggaagcttta tgagtcagtg aagaaagagt tggatgtaaa atcacaaaaa    960
 gaaaatgtcc tacagtattg tagaaaatct ggattacaaa ctgattacgc aacagagaaa   1020
 gaaagtgctg atggtttaca gggggagacc caactgttgg tctcgcgtaa gtcaagacca   1080
 aaatctggtg ggagcggcca cgctgtggca gagcctgctt cacctgaaca agagcttgac   1140
 cagaacaagg ggaagggaag agacgtggag tctgttcaga ctcccagcaa ggctgtgggc   1200
 gccagctttc ctctctatga gccggctaaa atgaagaccc ctgtacaata ttcacagcaa   1260
 caaaattctc cacaaaaaca taagaacaaa gacctgtata ctactggtag aagagaatct   1320
 gtgaatctgg gtaaaagtga aggcttcaag gctggtgata aaactcttac tcccaggaag   1380
 ctttcaacta gaaatcgaac accagctaaa gttgaagatg cagctgactc tgccactaag   1440
 ccagaaaatc tctcttccaa aaccagagga agtattccta cagatgtgga agttctgcct   1500
 acggaaactg aaattcacaa tgagccattt ttaactctgt ggctcactca agttgagagg   1560
 aagatccaaa aggattccct cagcaagcct gagaaattgg gcactacagc tggacagatg   1620
 tgctctgggt tacctggtct tagttcagtt gatatcaaca actttggtga ttccattaat   1680
 gagagtgagg gaataccttt gaaaagaagg cgtgtgtcct ttggtgggca cctaagacct   1740
 gaactatttg atgaaaactt gcctcctaat acgcctctca aaaggggaga agccccaacc   1800
 aaaagaaagt ctctggtaat gcacactcca cctgtcctga agaaaatcat caaggaacag   1860
 cctcaaccat caggaaaaca agagtcaggt tcagaaatcc atgtggaagt gaaggcacaa   1920
 agcttggtta taagccctcc agctcctagt cctaggaaaa ctccagttgc cagtgatcaa   1980
 cgccgtaggt cctgcaaaac agcccctgct tccagcagca aatctcagac agaggttcct   2040
 aagagaggag gagaaagagt ggcaacctgc cttcaaaaga gagtgtctat cagccgaagt   2100
 caacatgata ttttacagat gatatgttcc aaaagaagaa gtggtgcttc ggaagcaaat   2160
 ctgattgttg caaaatcatg ggcagatgta gtaaaacttg gtgcaaaaca aacacaaact   2220
 aaagtcataa aacatggtcc tcaaaggtca atgaacaaaa ggcaaagaag acctgctact   2280
 ccaaagaagc ctgtgggcga agttcacagt caatttagta caggccacgc aaactctcct   2340
 tgtaccataa taatagggaa agctcatact gaaaaagtac atgtgcctgc tcgaccctac   2400
 agagtgctca acaacttcat ttccaaccaa aaaatggact ttaaggaaga tctttcagga   2460
 atagctgaaa tgttcaagac cccagtgaag gagcaaccgc agttgacaag cacatgtcac   2520
 atcgctattt caaattcaga gaatttgctt ggaaaacagt ttcaaggaac tgattcagga   2580
 gaagaacctc tgctccccac ctcagagagt tttggaggaa atgtgttctt cagtgcacag   2640
 aatgcagcaa aacagccatc tgataaatgc tctgcaagcc ctcccttaag acggcagtgt   2700
 attagagaaa atggaaacgt agcaaaaacg cccaggaaca cctacaaaat gacttctctg   2760
 gagacaaaaa cttcagatac tgagacagag ccttcaaaaa cagtatccac tgtaaacagg   2820
 tcaggaaggt ctacagagtt caggaatata cagaagctac ctgtggaaag taagagtgaa   2880
 gaaacaaata cagaaattgt tgagtgcatc ctaaaaagag gtcagaaggc aacactacta   2940
 caacaaagga gagaaggaga gatgaaggaa atagaaagac cttttgagac atataaggaa   3000
 aatattgaat taaaagaaaa cgatgaaaag atgaaagcaa tgaagagatc aagaacttgg   3060
 gggcagaaat gtgcaccaat gtctgacctg acagacctca agagcttgcc tgatacagaa   3120
 ctcatgaaag acacggcacg tggccagaat ctcctccaaa cccaagatca tgccaaggca   3180
 ccaaagagtg agaaaggcaa aatcactaaa atgccctgcc agtcattaca accagaacca   3240
 ataaacaccc caacacacac aaaacaacag ttgaaggcat ccctggggaa agtaggtgtg   3300
 aaagaagagc tcctagcagt cggcaagttc acacggacgt caggggagac cacgcacacg   3360
 cacagagagc cagcaggaga tggcaagagc atcagaacgt ttaaggagtc tccaaagcag   3420
 atcctggacc cagcagcccg tgtaactgga atgaagaagt ggccaagaac gcctaaggaa   3480
 gaggcccagt cactagaaga cctggctggc ttcaaagagc tcttccagac accaggtccc   3540
 tctgaggaat caatgactga tgagaaaact accaaaatag cctgcaaatc tccaccacca   3600
 gaatcagtgg acactccaac aagcacaaag caatggccta agagaagtct caggaaagca   3660
 gatgtagagg aagaattctt agcactcagg aaactaacac catcagcagg gaaagccatg   3720
 cttacgccca aaccagcagg aggtgatgag aaagacatta aagcatttat gggaactcca   3780
 gtgcagaaac tggacctggc aggaacttta cctggcagca aaagacagct acagactcct   3840
 aaggaaaagg cccaggctct agaagacctg gctggcttta aagagctctt ccagactcct   3900
 ggtcacaccg aggaattagt ggctgctggt aaaaccacta aaataccctg cgactctcca   3960
 cagtcagacc cagtggacac cccaacaagc acaaagcaac gacccaagag aagtatcagg   4020
 aaagcagatg tagagggaga actcttagcg tgcaggaatc taatgccatc agcaggcaaa   4080
 gccatgcaca cgcctaaacc atcagtaggt gaagagaaag acatcatcat atttgtggga   4140
 actccagtgc agaaactgga cctgacagag aacttaaccg gcagcaagag acggccacaa   4200
 actcctaagg aagaggccca ggctctggaa gacctgactg gctttaaaga gctcttccag   4260
 acccctggtc atactgaaga agcagtggct gctggcaaaa ctactaaaat gccctgcgaa   4320
 tcttctccac cagaatcagc agacacccca acaagcacaa gaaggcagcc caagacacct   4380
 ttggagaaaa gggacgtaca gaaggagctc tcagccctga agaagctcac acagacatca   4440
 ggggaaacca cacacacaga taaagtacca ggaggtgagg ataaaagcat caacgcgttt   4500
 agggaaactg caaaacagaa actggaccca gcagcaagtg taactggtag caagaggcac   4560
 ccaaaaacta aggaaaaggc ccaaccccta gaagacctgg ctggctggaa agagctcttc   4620
 cagacaccag tatgcactga caagcccacg actcacgaga aaactaccaa aatagcctgc   4680
 agatcacaac cagacccagt ggacacacca acaagctcca agccacagtc caagagaagt   4740
 ctcaggaaag tggacgtaga agaagaattc ttcgcactca ggaaacgaac accatcagca   4800
 ggcaaagcca tgcacacacc caaaccagca gtaagtggtg agaaaaacat ctacgcattt   4860
 atgggaactc cagtgcagaa actggacctg acagagaact taactggcag caagagacgg   4920
 ctacaaactc ctaaggaaaa ggcccaggct ctagaagacc tggctggctt taaagagctc   4980
 ttccagacac gaggtcacac tgaggaatca atgactaacg ataaaactgc caaagtagcc   5040
 tgcaaatctt cacaaccaga cctagacaaa aacccagcaa gctccaagcg acggctcaag   5100
 acatccctgg ggaaagtggg cgtgaaagaa gagctcctag cagttggcaa gctcacacag   5160
 acatcaggag agactacaca cacacacaca gagccaacag gagatggtaa gagcatgaaa   5220
 gcatttatgg agtctccaaa gcagatctta gactcagcag caagtctaac tggcagcaag   5280
 aggcagctga gaactcctaa gggaaagtct gaagtccctg aagacctggc cggcttcatc   5340
 gagctcttcc agacaccaag tcacactaag gaatcaatga ctaatgaaaa aactaccaaa   5400
 gtatcctaca gagcttcaca gccagaccta gtggacaccc caacaagctc caagccacag   5460
 cccaagagaa gtctcaggaa agcagacact gaagaagaat ttttagcatt taggaaacaa   5520
 acgccatcag caggcaaagc catgcacaca cccaaaccag cagtaggtga agagaaagac   5580
 atcaacacgt ttttgggaac tccagtgcag aaactggacc agccaggaaa tttacctggc   5640
 agcaatagac ggctacaaac tcgtaaggaa aaggcccagg ctctagaaga actgactggc   5700
 ttcagagagc ttttccagac accatgcact gataacccca cagctgatga gaaaactacc   5760
 aaaaaaatac tctgcaaatc tccgcaatca gacccagcgg acaccccaac aaacacaaag   5820
 caacggccca agagaagcct caagaaagca gacgtagagg aagaattttt agcattcagg   5880
 aaactaacac catcagcagg caaagccatg cacacgccta aagcagcagt aggtgaagag   5940
 aaagacatca acacatttgt ggggactcca gtggagaaac tggacctgct aggaaattta   6000
 cctggcagca agagacggcc acaaactcct aaagaaaagg ccaaggctct agaagatctg   6060
 gctggcttca aagagctctt ccagacacca ggtcacactg aggaatcaat gaccgatgac   6120
 aaaatcacag aagtatcctg caaatctcca caaccagacc cagtcaaaac cccaacaagc   6180
 tccaagcaac gactcaagat atccttgggg aaagtaggtg tgaaagaaga ggtcctacca   6240
 gtcggcaagc tcacacagac gtcagggaag accacacaga cacacagaga gacagcagga   6300
 gatggaaaga gcatcaaagc gtttaaggaa tctgcaaagc agatgctgga cccagcaaac   6360
 tatggaactg ggatggagag gtggccaaga acacctaagg aagaggccca atcactagaa   6420
 gacctggccg gcttcaaaga gctcttccag acaccagacc acactgagga atcaacaact   6480
 gatgacaaaa ctaccaaaat agcctgcaaa tctccaccac cagaatcaat ggacactcca   6540
 acaagcacaa ggaggcggcc caaaacacct ttggggaaaa gggatatagt ggaagagctc   6600
 tcagccctga agcagctcac acagaccaca cacacagaca aagtaccagg agatgaggat   6660
 aaaggcatca acgtgttcag ggaaactgca aaacagaaac tggacccagc agcaagtgta   6720
 actggtagca agaggcagcc aagaactcct aagggaaaag cccaacccct agaagacttg   6780
 gctggcttga aagagctctt ccagacacca gtatgcactg acaagcccac gactcacgag   6840
 aaaactacca aaatagcctg cagatctcca caaccagacc cagtgggtac cccaacaatc   6900
 ttcaagccac agtccaagag aagtctcagg aaagcagacg tagaggaaga atccttagca   6960
 ctcaggaaac gaacaccatc agtagggaaa gctatggaca cacccaaacc agcaggaggt   7020
 gatgagaaag acatgaaagc atttatggga actccagtgc agaaattgga cctgccagga   7080
 aatttacctg gcagcaaaag atggccacaa actcctaagg aaaaggccca ggctctagaa   7140
 gacctggctg gcttcaaaga gctcttccag acaccaggca ctgacaagcc cacgactgat   7200
 gagaaaacta ccaaaatagc ctgcaaatct ccacaaccag acccagtgga caccccagca   7260
 agcacaaagc aacggcccaa gagaaacctc aggaaagcag acgtagagga agaattttta   7320
 gcactcagga aacgaacacc atcagcaggc aaagccatgg acaccccaaa accagcagta   7380
 agtgatgaga aaaatatcaa cacatttgtg gaaactccag tgcagaaact ggacctgcta   7440
 ggaaatttac ctggcagcaa gagacagcca cagactccta aggaaaaggc tgaggctcta   7500
 gaggacctgg ttggcttcaa agaactcttc cagacaccag gtcacactga ggaatcaatg   7560
 actgatgaca aaatcacaga agtatcctgt aaatctccac agccagagtc attcaaaacc   7620
 tcaagaagct ccaagcaaag gctcaagata cccctggtga aagtggacat gaaagaagag   7680
 cccctagcag tcagcaagct cacacggaca tcaggggaga ctacgcaaac acacacagag   7740
 ccaacaggag atagtaagag catcaaagcg tttaaggagt ctccaaagca gatcctggac   7800
 ccagcagcaa gtgtaactgg tagcaggagg cagctgagaa ctcgtaagga aaaggcccgt   7860
 gctctagaag acctggttga cttcaaagag ctcttctcag caccaggtca cactgaagag   7920
 tcaatgacta ttgacaaaaa cacaaaaatt ccctgcaaat ctcccccacc agaactaaca   7980
 gacactgcca cgagcacaaa gagatgcccc aagacacgtc ccaggaaaga agtaaaagag   8040
 gagctctcag cagttgagag gctcacgcaa acatcagggc aaagcacaca cacacacaaa   8100
 gaaccagcaa gcggtgatga gggcatcaaa gtattgaagc aacgtgcaaa gaagaaacca   8160
 aacccagtag aagaggaacc cagcaggaga aggccaagag cacctaagga aaaggcccaa   8220
 cccctggaag acctggccgg cttcacagag ctctctgaaa catcaggtca cactcaggaa   8280
 tcactgactg ctggcaaagc cactaaaata ccctgcgaat ctcccccact agaagtggta   8340
 gacaccacag caagcacaaa gaggcatctc aggacacgtg tgcagaaggt acaagtaaaa   8400
 gaagagcctt cagcagtcaa gttcacacaa acatcagggg aaaccacgga tgcagacaaa   8460
 gaaccagcag gtgaagataa aggcatcaaa gcattgaagg aatctgcaaa acagacaccg   8520
 gctccagcag caagtgtaac tggcagcagg agacggccaa gagcacccag ggaaagtgcc   8580
 caagccatag aagacctagc tggcttcaaa gacccagcag caggtcacac tgaagaatca   8640
 atgactgatg acaaaaccac taaaataccc tgcaaatcat caccagaact agaagacacc   8700
 gcaacaagct caaagagacg gcccaggaca cgtgcccaga aagtagaagt gaaggaggag   8760
 ctgttagcag ttggcaagct cacacaaacc tcaggggaga ccacgcacac cgacaaagag   8820
 ccggtaggtg agggcaaagg cacgaaagca tttaagcaac ctgcaaagcg gaacgtggac   8880
 gcagaagatg taattggcag caggagacag ccaagagcac ctaaggaaaa ggcccaaccc   8940
 ctggaagacc tggccagctt ccaagagctc tctcaaacac caggccacac tgaggaactg   9000
 gcaaatggtg ctgctgatag ctttacaagc gctccaaagc aaacacctga cagtggaaaa   9060
 cctctaaaaa tatccagaag agttcttcgg gcccctaaag tagaacccgt gggagacgtg   9120
 gtaagcacca gagaccctgt aaaatcacaa agcaaaagca acacttccct gcccccactg   9180
 cccttcaaga ggggaggtgg caaagatgga agcgtcacgg gaaccaagag gctgcgctgc   9240
 atgccagcac cagaggaaat tgtggaggag ctgccagcca gcaagaagca gagggttgct   9300
 cccagggcaa gaggcaaatc atccgaaccc gtggtcatca tgaagagaag tttgaggact   9360
 tctgcaaaaa gaattgaacc tgcggaagag ctgaacagca acgacatgaa aaccaacaaa   9420
 gaggaacaca aattacaaga ctcggtccct gaaaataagg gaatatccct gcgctccaga   9480
 cgccaagata agactgaggc agaacagcaa ataactgagg tctttgtatt agcagaaaga   9540
 atagaaataa acagaaatga aaagaagccc atgaagacct ccccagagat ggacattcag   9600
 aatccagatg atggagcccg gaaacccata cctagagaca aagtcactga gaacaaaagg   9660
 tgcttgaggt ctgctagaca gaatgagagc tcccagccta aggtggcaga ggagagcgga   9720
 gggcagaaga gtgcgaaggt tctcatgcag aatcagaaag ggaaaggaga agcaggaaat   9780
 tcagactcca tgtgcctgag atcaagaaag acaaaaagcc agcctgcagc aagcactttg   9840
 gagagcaaat ctgtgcagag agtaacgcgg agtgtcaaga ggtgtgcaga aaatccaaag   9900
 aaggctgagg acaatgtgtg tgtcaagaaa ataacaacca gaagtcatag ggacagtgaa   9960
 gatatttgac agaaaaatcg aactgggaaa aatataataa agttagtttt gtgataagtt  10020
 ctagtgcagt ttttgtcata aattacaagt gaattctgta agtaaggctg tcagtctgct  10080
 taagggaaga aaactttgga tttgctgggt ctgaatcggc ttcataaact ccactgggag  10140
 cactgctggg ctcctggact gagaatagtt gaacaccggg ggctttgtga aggagtctgg  10200
 gccaaggttt gccctcagct ttgcagaatg aagccttgag gtctgtcacc acccacagcc  10260
 accctacagc agccttaact gtgacacttg ccacactgtg tcgtcgtttg tttgcctatg  10320
 ttctccaggg cacggtggca ggaacaacta tcctcgtctg tcccaacact gagcaggcac  10380
 tcggtaaaca cgaatgaatg gataagcgca cggatgaatg gagcttacaa gatctgtctt  10440
 tccaatggcc gggggcattt ggtccccaaa ttaaggctat tggacatctg cacaggacag  10500
 tcctattttt gatgtccttt cctttctgaa aataaagttt tgtgctttgg agaatgactc  10560
 gtgagcacat ctttagggac caagagtgac tttctgtaag gagtgactcg tggcttgcct  10620
 tggtctcttg ggaatacttt tctaactagg gttgctctca cctgagacat tctccacccg  10680
 cggaatctca gggtcccagg ctgtgggcca tcacgacctc aaactggctc ctaatctcca  10740
 gctttcctgt cattgaaagc ttcggaagtt tactggctct gctcccgcct gttttctttc  10800
 tgactctatc tggcagcccg atgccaccca gtacaggaag tgacaccagt actctgtaaa  10860
 gcatcatcat ccttggagag actgagcact cagcaccttc agccacgatt tcaggatcgc  10920
 ttccttgtga gccgctgcct ccgaaatctc ctttgaagcc cagacatctt tctccagctt  10980
 cagacttgta gatataactc gttcatcttc atttactttc cactttgccc cctgtcctct  11040
 ctgtgttccc caaatcagag aatagcccgc catcccccag atcacctgtc tggattcctc  11100
 cccattcacc caccttgcca ggtgcaggtg aggatggtgc accagacagg gtagctgtcc  11160
 cccaaaatgt gccctgtgcg ggcagtgccc tgtctccacg tttgtttccc cagtgtctgg  11220
 cggggagcca ggtgacatca taaatacttg ctgaatgaat gcagaaatca gcggtactga  11280
 cttgtactat attggctgcc atgatagggt tctcacagcg tcatccatga tcgtaaggga  11340
 gaatgacatt ctgcttgagg gagggaatag aaaggggcag ggaggggaca tctgagggct  11400
 tcacagggct gcaaagggta cagggattgc accagggcag aacaggggag ggtgttcaag  11460
 gaagagtggc tcttagcaga ggcactttgg aaggtgtgag gcataaatgc ttccttctac  11520
 gtaggccaac ctcaaaactt tcagtaggaa tgttgctatg atcaagttgt tctaacactt  11580
 tagacttagt agtaattatg aacctcacat agaaaaattt catccagcca tatgcctgtg  11640
 gagtggaata ttctgtttag tagaaaaatc ctttagagtt cagctctaac cagaaatctt  11700
 gctgaagtat gtcagcacct tttctcaccc tggtaagtac agtatttcaa gagcacgcta  11760
 agggtggttt tcattttaca gggctgttga tgatgggtta aaaatgttca tttaagggct  11820
 acccccgtgt ttaatagatg aacaccactt ctacacaacc ctccttggta ctgggggagg  11880
 gagagatctg acaaatactg cccattcccc taggctgact ggatttgaga acaaataccc  11940
 acccatttcc accatggtat ggtaacttct ctgagcttca gtttccaagt gaatttccat  12000
 gtaataggac attcccatta aatacaagct gtttttactt tttcgcctcc cagggcctgt  12060
 gcgatctggt cccccagcct ctcttgggct ttcttacact aactctgtac ctaccatctc  12120
 ctgcctccct taggcaggca cctccaacca ccacacactc cctgctgttt tccctgcctg  12180
 gaactttccc accagcccca ccaagatcat ttcatccagt cctgagctca gcttaaggga  12240
 ggcttcttgc ctgtgggttc cctcaccccc atgcctgtcc tccaggctgg ggcaggttct  12300
 tagtttgcct ggaattgttc tgtacctctt tgtagcacgt agtgttgtga aactaagcca  12360
 ctaattgagt ttctggctcc cctcctgggg ttgtaagttt tgttcattca tgagggccga  12420
 ctgtatttcc tggttactgt atcccagtga ccagccacag gagatgtcca ataaagtatg  12480
 tgatgaaatg gtcttaaaaa aaaaaaaaaa aaaaaaa                           12517



      <210> 451
      <211> 372
      <212> DNA
      <213> Homo sapiens


      <400> 451
 ttgtgggtgg cgggacaggc ttcattggga cagccctaac ccagctgctg aatgccagag     60
 gccacgaagt gacgttggtc tcccgaaagc ccgggcccgg ccggatcacg tgggatgagc    120
 tcgctgcatc ggggctgccg agctgcgatg ccgccgtcaa cctggccgga gagaacatcc    180
 tcaaccctct ccgaaggtca gcccgggccc taaagctgat acccactaga gcacagggag    240
 gacagtgccc cactgatgag aacctgtgag ctatggctta ctaccagccc agtctgactg    300
 cggagtatga tgaagacagc ccaggagggg actttgactt tttctccaac ctcgtaacca    360
 aatgggaagc tg                                                        372



      <210> 452
      <211> 1112
      <212> DNA
      <213> Homo sapiens


      <400> 452
 atcttgacga ggctgcggtg tctgctgcta ttctccgagc ttcgcaatgg taagcttcag     60
 gggtgtgaag tcgccggcgt tcttgggttt gaggactcag tggggagagc cttcggcggg    120
 agcgctcctt ggcctgccgg cctcggttgc agggcgggcg cggttattgc ttggcccatg    180
 tgctctggtg gtggagtttg cgggggctgg gggcgcagta ttaggggact ttggcgctat    240
 ttgaggacct ggttgcattc ccgctgccct cctacagccg cctaaggacg acaagaagaa    300
 gaaggacgct ggaaagtcgg cccaaagaaa gacaaagacc cagtgaacaa atccggggca    360
 aaggccaaaa agaaggtaga aataagacct ctctgaaaga gactaggggt aactctctcg    420
 taaccctcta gtaataggga acttggataa gtaagtggtt tttcaggtgt agatttctag    480
 agtcaaaatg tgagagttta tcttcccgtc accactcgtt ctttttccca ttaggatcat    540
 gaaaatgggt ctgttgtgcg aagtgtctgc cgctgtgcct gctgtgttat ttttaactga    600
 tctagtgggg ctcggcccct gtttgaaggc caaaaacgtg tcggtgtttt ttttttttgt    660
 ttttgtttta gtaatgtgta atttatcctt gataacggtg gaacagattt ctctgacgca    720
 gattactcga gagggaaagg gtgcttctgc cagaaatact aacttgtttc tgttttgttt    780
 tggtgagcag aagtggtcca aaggcaaagt tcgggacaag ctcaataact tagtcttgtt    840
 tgacaaagct acctatgata aactctgtaa ggaagttccc aactataaac ttataacccc    900
 agctgtggtc tctgagagac tgaagattcg aggctccctg gccagggcag cccttcagga    960
 gctccttagt aaaggactta tcaaactggt ttcaaagcac agagctcaag taatttacac   1020
 cagaaatacc aagggtggag atgctccagc tgctggtgaa gatgcatgaa taggtccaac   1080
 cagctgtaca tttggaaaaa taaaacttta tt                                 1112



      <210> 453
      <211> 792
      <212> DNA
      <213> Homo sapiens


      <400> 453
 atggcgccgc ccacgtgtgg tacggcccac gtggttccga cagtcaagat ggcgggagca     60
 gctcccaggc ttccctggag tcggccccac ggatcatgcg gctggtggcc gatgcagccg    120
 ctccagggcc cgggcaggcg agctgtggct gccgcatggg aagtggccac tcctgtgttc    180
 atgccagtgg gcacgcaggc caccatgaag gcatcacgac cgaacagctg gacgctctgg    240
 gttgccgcat ctgcctggga atacctacca tctgggtcta aggccggtgg gacagcggcg    300
 tttccagatg gtgtcgctgg tgtctctgtc cgaggtgacg gaggagggct ccgcttccgc    360
 tccccctacg acggcaatga gaccctgctg agcccggaaa atccgtgcag atccagaatg    420
 cgctgggccc ctggggttgt gactggggcc ctgttgcagg tcaatccgct ggctggaccg    480
 gtgcatgcag cccatcagcg gccggacaag cagaacctct tcgccattat ccaggtgggc    540
 tggacgcaga tctccgggcc acctgccttg aagcgctttg gctctgcctg gcacagccgc    600
 gccttcctca cgcactgctg cacagtgaca acacggccgc gctgcaccac ctcacggcca    660
 caacatcgcc taccagctga gctcatgagc gccgtccgca ccagcatcgt ggagaagcgc    720
 ttcccggatt cgtgcgggac ttcatgggcg ccatgtacgg ggatcccacc ctctgtccac    780
 ctgggccact ga                                                        792



      <210> 454
      <211> 1716
      <212> DNA
      <213> Homo sapiens


      <400> 454
 tggtggaatt cgtacatcag agaattcata tttgatagag aaattgtggc atatacaggt     60
 agtaaagaaa gcacattgtg tcaatggatt tatcccactg aacaatttga atgaagacaa    120
 tgtggaatgg ctttgagata cagttcagtt tttattaggc atcaatttgt attggtgtga    180
 acttttcaaa atgtaaatca tatatgcagt ttctttggta tgacctgtgt taactcagat    240
 tcagagaatt tataatgtat ttttttaata acataagaaa acttttctga tattcctcta    300
 gttttggatt gccaaaatat tcacagtaga ggaaaactga gaaaacgtag gaaaccattc    360
 tttatacttg catgtaaaca tcttccagca acaatcattt attgttaaac ctggaaaaag    420
 ccattacaca ggaaacctct gttgatataa gcgatgatgg gaaaggctat ttagccactc    480
 tgcatattta atgctcatga tcaacatctg cttcctatag ctgggatgat atgggggaag    540
 atatttatcc cttctgggga tcatatataa atgatgatag tagtacctac agtatagtgc    600
 tgttagaatt acgtgagtta gatgtggagg tcagagtgga agcaggtgtg agagggtccc    660
 gcagaagaaa acatggctgc caaagtgttt gagtccatcg gcaagtttgg cctggcctta    720
 tctgatgcaa gatagcatgg tgaactctgc cttatgtaat gtgtatgctg ggcacagagc    780
 tgccatcttt gaccaatttc gtggagtaca gaacattgtg gtatgggaag ggactcactt    840
 tctcatccca tgtgtacgaa aaccaattat gtttgactgc tgttctcaac cacgtagtcc    900
 gccagtcatc actggtagca aagatttaca gaatgtcaac atcacactgt gcatcctctt    960
 ccggcccatc actagccagc ttcctcgcat cttcaccagc attggagagg actacgatga   1020
 gtgtgtgctg ccgttcatta ccacggagat cctcaagtca ctggtggctc gctttgatgc   1080
 tggagaacta atcacccaga gggagctggt ctccagccag gtgagcaaca accttatgga   1140
 gtgagcagcc acctttgggc tcattctgga cgacgtgtct ttgacacatc tgaccttctt   1200
 gaaggagtta acagacaggt ggccccccag gaagcagaga gcgccagatt tgtggtggaa   1260
 aaggcggcca tcatctctgc tgagggtgac tccaaggcag ctgaagctga tcgccaactc   1320
 actggccact gcaggggacg gccagagcga gctgtgcaag ctggaagctg cagaagacat   1380
 tgcataccag ctctcatgct ctcggaacat cacctgcctg ccggcagggc agtccgtgct   1440
 cctccagctg ccctagtgag gccccagcct acctgcacct ccgtgaggca actgggcccc   1500
 agccccgatg attcgtaaca ccacctttcg ccctcacccc agaaatcact gaaatttcat   1560
 gattggctta aagtgaagga agtaaaggta aaatcacttc agatctctaa aaaacaaaga   1620
 tttacatgag ttagtacatc cacagattat gggtatggac atggaatata ctgttacgtt   1680
 caattaccat tagcttctgt atataataat atcaaa                             1716



      <210> 455
      <211> 624
      <212> DNA
      <213> Homo sapiens


      <400> 455
 ggcccagctg tgcccagatg gatgggacag agacccggca gcggaggctg gacagctgtg     60
 gcaaagccag gggagctggg gcttcctcac cccctcagca caggaggact ccctgtagcc    120
 tcagaagatg gagctctcag ggcccctgag agccaaagcg tgacccccaa gccactggag    180
 actgagccta gcagggagac cgcctggtcc ataggccttc aggtgaccgt gcccttcatg    240
 tttgcaggcc tgggactgtc ctgggccggc atgcttctgg actatttcca ggccaacact    300
 ggacaaattg atgaccccca ggagcagcac agagtcatca gcagcaacct ggccctcatc    360
 caggtgcagg ccactgtcgt ggggctcttg gctgctgtgg ctgcgctgct gttgggcgtg    420
 gtgtctcgag aggaagtgga tgtcgccaag gtggagttgc tgtgtgccag cagtgtcctc    480
 actgccttcc ttgcagcctt tgccctgggg gtgctgatgg tctgtatagt gattggtgct    540
 cgaaagctcg gggtcaaccc agacaacatt gccacgccca ttgcagccag gcctggagac    600
 ctcatcacac tgtccattct ggct                                           624



      <210> 456
      <211> 397
      <212> DNA
      <213> Homo sapiens


      <400> 456
 cgcggccgcg tcgaccttca atgtcacaca tgttggctgt gcttccaaga tccctaacac     60
 tgtctcttta aaagcagtac tgtccagact ctgggatcca tagatgggca tcaggagaga    120
 gatcttggaa gtaatccgaa atagtaaaac aaatttccta tgcataagct tttgtgtgtg    180
 cttggggtgg gggccggggg aagtattata gaggtggagg ggccatagct tacacgagat    240
 tttcaaaagg tctgtgactc aaaataactt aattgagtac agaataccta taatgtcctt    300
 gtgctgtgcc agcgatacac gacagtgttt aacactacgt cagttcccgc cgttaaaaag    360
 ctgacagtca ctgtgaatac aatctccatc ttctaaa                             397



      <210> 457
      <211> 1320
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1320)
      <223> n = a,t,c or g


      <400> 457
 agtcggctag gattgcaaag ctgtgggctg agcactcagg caatcacact ctcagaaact     60
 gcggcggctc tggactgcag cctcccaagg ctccatgccg gacaaagcat gcgtagtcac    120
 acttgctaca atagcctggg atggtttctt ttggtctcca atttattcac acacagcaaa    180
 tattttgcca gatatccgaa aatgaagatt tcatcaaaga ctgcgttccg aatccataac    240
 aagttcccga tcagaggtga aaccaacaag ccaagtgata tgcttataca tgacttggga    300
 cccagcacta gcccaaattg caaaagcatg ggccacgcaa ttgccacgtt ttcacataat    360
 acacggctga aagccacccc cacaagcctg gcatncaaac tttcactttc actggggaga    420
 gaacatcttg ggacttgggt ctgttgccca tttttttctg tgtcttccgc catcacaaac    480
 tgggtatgac gaaatcccag gactattgac ttcaagactc cggatatgcc aaaaaagtct    540
 gtggccaact acactcaggt tggtttgggc agattagtta caaagttggg ctgcgcagtt    600
 tcaattttgg ccctaaaagt ttctggcttt gaccgtcttt ctcccaatgg agcacatttt    660
 tatatgcaac taccgggccc aggagggaat tacccccaac ttggccatat aagagaggag    720
 ccaccctggc agtgcctgcc ccaataatga caaggtgttt ggacaatctc tgtgttaacc    780
 ggacagcgag accaagtcaa acgttactac tctgttgtat atccaggctg gcccatatat    840
 ccacggtaac agaggcgggt tctctctttc tcattggtaa ttcagtaatt ctaatactgt    900
 gtgttataat taccattttg gtacagcaca agtaccctaa tttagttctt ttggactaat    960
 acaattcagg aaagaaaaaa cccaaaaacc aacctcattc acatatggct ttttttttaa   1020
 ccaataacaa ttaggggcac ttctatttta aaacatttca gaaaaaaata tatgttatag   1080
 caatactctt actcaaaaga agaaatttcc taactctatc agataaactc atctttagta   1140
 tacctatgca ttattatgca ggttgtcaca acgtggactt ttattatgta tcctaactgc   1200
 atgttacacc ttctatatgc tgcagatcga tccctgtacc attgcacatt tttaggtgat   1260
 tctcaataac ttgcctaggc catattaact taaaaccatg atactttgag cgaggcgcat   1320



      <210> 458
      <211> 494
      <212> DNA
      <213> Homo sapiens


      <400> 458
 atgcctcagg atcagtcatc acttcgggaa tttgggcctc gaggcctaga attcggacta     60
 tcgctccagc gagacgccgt caagcagctt tgtagttttt aagagaagaa aaaggaggag    120
 aaagtcacac ctggccagcc tgaagagaga tgacaacatg aacacatctg aggatgagga    180
 catgttcccc atcgagatga gctcggatga ggccatggag ctgctggaga gcagcagaac    240
 tcttcctaat gatatacctc cattccaaga tgatattcct gaggaaaacc tctccctggc    300
 tgtgatttac cctcagtcag cctcataccc taattcggat agagagtggt cacccactcc    360
 cagtagcctg gtagattgca aaaggactgc ccctcatctt gcagttgcgg ccgagggagg    420
 tctgtctagt tcttgccctc cacagtcttc cctgttccat ccttcggaaa gtccttccgg    480
 ttcccgacct tcaa                                                      494



      <210> 459
      <211> 1013
      <212> DNA
      <213> Homo sapiens


      <400> 459
 gagactccca acacagggga agtctccagg acctccacac cattaacaag atgagccttg     60
 tgctcccttg ggctctagag aggaagcccc tctgagccct cagcccctct ttcctccctc    120
 tcctaaagta atttgatcct caggaatttg ttctgccctc atctggccct ggccagctct    180
 gcatttgaca aatgccagga agaggaaact gttgagaaaa cggaactact ggcggaaagg    240
 cgagggctca ctgagaaccc atcccggtta cccccgatca ccgctggtct tcgctcggac    300
 accatgaacc acattgttgc aaaccttctt ctctcctgtc aacagcggcc caggcttccc    360
 aactacgaga tgctcaagga ggagcacgag gtggctgtag ctgggggcgc cccaaaaacc    420
 gtgcttaccc gaatgtccac ctgtgatcca ctatccgcag gcgagacctc cgtggcctga    480
 ccatgttcgt ctggtcccgt gttcaaacac cctcttcaat gaacccctgc atgccgtggg    540
 cttcataagc attcgctcta ctccgtgaaa agtctaaggg acaggaaaga tggttggcga    600
 cgttgaaccg gggccccaag gcctaatgcc tccacccgcc aaagtgcctg aaaaatctgg    660
 gcccgtgatt ttggggcatc ttcatgaacc aattcttgct catcaatcat ccccccccaa    720
 gtgttgggtc gtccagggcc taatggatag atcaaggaag gcatcactga agggcaagga    780
 agctctgccc cgttgaacct gtaatcccac cgtactccaa ctttccattc ctcggcctgc    840
 ccccagaggc caggaagttc tgcccttgaa ctgtattcca cttactccac cttccattcc    900
 tcgccctgtc cccacagccg agtcctgcat cagcccttta tcctcacacg cttttctaca    960
 atggcattca ataaagtgta tatgtttctg gtaaaaaaaa aaaaaagtcg agc          1013



      <210> 460
      <211> 1160
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1160)
      <223> n = a,t,c or g


      <400> 460
 ctttccgctc ggctgttttc ctgcgcagga gccgcagggg ccggtaggcc agcccatggc     60
 gcccaagccg gaaatggcca tgggtcttga acgccccact tccaccaagg gactggcaag    120
 cgggcggcgt ggcccacgtg tttcaaacca gccgggccgg gtaagatccg ccagacgtaa    180
 aggccccgca aagcccaaag gcgccgccgc atcgctccgc gcccccgcgt cggggtccca    240
 atccggccca atcgtgcgct gccccacggg ttcgggtcca cacgaaggtt gcgcgccggc    300
 ccccggcttc cagccttgag gaagctcagg gtggccggca ttcacaagaa aggtggcccg    360
 gaccttcggc attttctgtg gatccgagga agccggacca agtcccacgg agttccttca    420
 aggccaaacg tgcagcggct gaaggagtac cgctccaaaa ctcatcctct ttccccagag    480
 aagccctcgg ccccccaaga agggagacag gtctggctga agaactgaaa ctggcccacc    540
 cagcttgacg ggaccggtca atgcccgtcc ggaacgttca aatagaagga gaaagctcga    600
 gtcatcactg agcaagcaga agaatttcaa agccttcgct agtctccgta tggcccgtgc    660
 caacgccccg gctcttcggc atacgggcca aaaagagccc agggaagccg cagaaccagg    720
 atgttgaaaa gcccacaata aagnccctgc ctggggactt tggaatcaag tcgggcagtc    780
 atgctgggtc tccacgtggt gtgtttcgtg ggaacaactg ggcctgggat ggggcttcac    840
 tgctgtgact tcctcctgcc aggggatttg gggctttctt gaaagacagt ccaagcccct    900
 ggataatgct ttactttttg tgttgaagcc ctgttggttg tttggttagt gactgatgta    960
 aaacggtttt cttgtggggg gggtaccaaa ggctgacttc agagtggact tgtgtttttt   1020
 ctttttaaag aggcaaggtt gggctggtgc tcacagctgt aatcccagca ctttgagatt   1080
 ggctgggagt tcaagaccag cctggccaac atgtcagaac tactaaaaat aaagaaatca   1140
 gccatgaaaa aaaaaaaaaa                                               1160



      <210> 461
      <211> 1591
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1591)
      <223> n = a,t,c or g


      <400> 461
 gcggccgcgg agctgggaag gccgagggcg ccgggcacgt ctgtgcagat ttctttagag     60
 tcgaggtctg tcgcccgcgt cttcgtcggt ggcagcaggg ctgactggcc acggcggcca    120
 tctgctagag cgcatttctt accatgaaac gccacctcct ccgaagtgcg gagcgaacgc    180
 agccaaatct acacaaagac tgacaagctg gatccactcg acggaaccca gggccaaaaa    240
 acggcggcga gcagcgcctc gggcccgcga ttaccggttt tctgagcacc ggacagcgtg    300
 agccgtgcca gccctgtctc gccatcccag ccgaggaggg cagcgcgatg gctcttccct    360
 gccttgaaat caaccccatt gccagccgct ttcgccggca gagcattttc cgtggggtcc    420
 atccggctcc aaggcggcct gcgctggcca cgtggaaaga aacacgccca ctgcctacag    480
 gccacgccct tcctcccttc gcgcatgcgc cccacccgtc ctgaggacct ccgaacctgc    540
 agggggcgat gaaagtaggc ttgcgctccg cttgtagctg cttccgggtc agaggtcaga    600
 cggtctagcg ctgcgtgggc catggtgcag ctccgaccgc gagcgtctcg cgccccggcg    660
 tcggcggagg cgatggtgga cgagggccag ctggcctcgg aggaggagga ggcggagcac    720
 gggctgttgc tcgggcagcc cagcagcggc gcggccgccg agccccttgg aggaagacga    780
 cagaagggga cgatgagttt gacgatggag gccccgaaga gcatgancta ttcgccagcg    840
 ccccaggcgg aagcgagaga agaggagcgg cgagtgcggg agaccgtgcg cagggataaa    900
 acgctcctga aggagaagag gaagcggacg cggaggagct gttcatcgaa cagaagaaaa    960
 gaaaacttcc ttccagacac tattttggag aatgttaacc acagcttcac agactaacat   1020
 caagaaattc cgccaggaaa cggtgaaaga aggttaattt gcaaaagaaa aatgaagact   1080
 tgtgaaaaag gaaattgact ccaagaaagt taaagtacaa aaagtacagt ctggtcagcc   1140
 cagaataaaa gctagcttcg gccgtaaggc taaaaggacc aagattctgg agagattcaa   1200
 gggcaacaag cagcacaagc ctttcataca taattcatta tatgggccag gaaccaaaca   1260
 ggactactgt aaataagttc ctgtctcttg accaacaaga ggttaccagt gaaaagagac   1320
 tgctgtacca gttttttgaa taatgacttg gggaatccaa aaaaaaacaa aatgaccaag   1380
 aggtttaaaa gaacggtggg atgggtcagg aaaggatgga aaactaagga agtaaatcca   1440
 atgcttaaat gaaggaatct gttactttgt tatgttatag gatttatctt attaaatcat   1500
 tccttggatc atttttaaag gatccttttt taaaaatcat aaacctattt gaggaagtgc   1560
 tcaaccacat ttcattcttc tggagtagaa c                                  1591



      <210> 462
      <211> 1659
      <212> DNA
      <213> Homo sapiens


      <400> 462
 tggcactagg ggcagccact cagcccttcg agctgtaggg gaggcgctgc gcccccggcc     60
 ccagccgatc gggggctcct ggcgctagcc tcgcctccag agcgccgcag gagtccctcc    120
 tgccgtctga cttgagtccc tgctgctgca gtgcacgccc ccctttcggc agccagggtg    180
 gggcccagac ccaacctggc ccctcctgcc cccaccccgc ctttgggtcg ctgaccccca    240
 ggctgtggtg agggtctgag agctggtacc acggagcctg ggcaacctcc tccgcccacc    300
 catgcccacc ccgcatgagg ctgagaagca gatcacaggg ccagaggagg cggaccggcc    360
 cccttcaatg tccagtcatg atacagcctc tccagcggcc cccagccgaa gccccatgct    420
 gcctgtgctg gtgctgatgt tgtaactgct cctggaacca acagcggcgg cgcgcgtggc    480
 aagcctcccg ggagagcaaa ctgcagcccc tcacccatct gcgaagtatg tgccacgcca    540
 agtcctgagg aggtgcagag ctgggcgcag tcttttgaca agctgatgca cagccttgcg    600
 ggactcagcg tgttccgggc gttcctgcgg acagagtaca gcgaggagaa catgctcttc    660
 tggttggcct gcgaggagct gaaggccgag gccaaccagc atgtggtaga cgagaaggcg    720
 aggctcatct acgaggacta cgtatccatc ctgtccccca aggaggtgag cctggactcc    780
 cgtgtgcggg agggcatcaa caagaatatg caggagccgt ccgcacacac gttccgacga    840
 cgcgcagctg cagatctaca cgctcatgca ccgggactcc tacccccgct tcctcagctc    900
 tcccacctta cccgtgccct gcttgctgca ggggccattc acagtccttc cttcccgagg    960
 ccttaggccg ccccccagca gcacagaccc cgccgcctcc tacggccgac tctgggttcc   1020
 cttcaggtgt tggtgtcggc agggctgtca gggcacatgc ctggccggct ggggtcccca   1080
 cccgcggaag acggtcctta gacccagttg ggaagtgctg tgtctcctgg gtctgcccac   1140
 ccgtggccaa gcaggaactc caggtgcagg gcgggcctcc aggtgcaggg cgggccagaa   1200
 gccccctcat cggcccgcag ctggctggcc cagtgctcct ggctgggggc tcttgcgtgg   1260
 tgagagtaag gggtcccccc aggagccatg ctggacccat gagcctcgtt ggggcctcct   1320
 ccacaggcag ccgatgggcc ccagacaagc ctttggtggg gaacagaacc tccgcatcgt   1380
 gtagttttgt gacataagga gacctcttac ttgagctgtc tgtaccccag aaatcaaaca   1440
 cagaacctca gaaccagatt taggacctca gaatcctgca ctcaaggtgg caggacccaa   1500
 tttctgtttt atatgtctca tgaactttaa acctggaaac atgtccttac taggtgtttt   1560
 atcaaaaaaa agttttcata tttatctcta tccctaaccc cccaaaaata ggatgtctta   1620
 ttattgaaga tatttttaaa gcaaaaaaaa aaaaaaaaa                          1659



      <210> 463
      <211> 411
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(411)
      <223> n = a,t,c or g


      <400> 463
 cccacgcgtc cgcccacgcg tncggaggaa agaacaattg aaactgcaaa agggattaat     60
 ggaactgtaa attatgatag tgtcaattct gacaactcta agccaaagat atttaaaagt    120
 caaatagaga acataaattt gaccaatggc agcaatggga ggaacacaga gtccccagct    180
 gccattcacc cttgtggaaa tcctacagtg attgaggacg ctttggacaa gattaaaagc    240
 aatgaccctg acaccacaga agtcaatttg aacaacattg agaacatcac aacacagacc    300
 cttacctccc cctccttctt cccaaaggct gccaccacct cctcctcctc cccctccttc    360
 actcccagag aaaaagctca ttaccagaaa cattgcagaa gtcatcanac a             411



      <210> 464
      <211> 411
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(411)
      <223> n = a,t,c or g


      <400> 464
 cccacgcgtc cgcccacgcg tncggaggaa agaacaattg aaactgcaaa agggattaat     60
 ggaactgtaa attatgatag tgtcaattct gacaactcta agccaaagat atttaaaagt    120
 caaatagaga acataaattt gaccaatggc agcaatggga ggaacacaga gtccccagct    180
 gccattcacc cttgtggaaa tcctacagtg attgaggacg ctttggacaa gattaaaagc    240
 aatgaccctg acaccacaga agtcaatttg aacaacattg agaacatcac aacacagacc    300
 cttacctccc cctccttctt cccaaaggct gccaccacct cctcctcctc cccctccttc    360
 actcccagag aaaaagctca ttaccagaaa cattgcagaa gtcatcanac a             411



      <210> 465
      <211> 428
      <212> DNA
      <213> Homo sapiens


      <400> 465
 atgcttacgg gatcacctgg cacgctctat gatccgtact gactggggag gaggtttacc     60
 tcgcggtgtc tctttcagcc gcaacgtact ccgggtcggc cttgcgctcg gggcctgaga    120
 ggggcggcgg cggggtcagg ggccgcacaa ataatgaacc agcagtggaa gagaaaatac    180
 tgtaagctgg ctgactgctg gtgaagaaaa tgctttattt ttgtggcagg catctgtggg    240
 atctgtaata aaaatgatgg ctggctgtgg tgaaattgat cattcaataa acatgcttcc    300
 tacaaacagg aaagcgaacg agtcctgttc taatactgca ccttctttaa ccgtccctga    360
 atgtgccatt tgtctgcaaa catgtgttca tccagtcagt ctgccctgta agcacgtttt    420
 ctgctatg                                                             428



      <210> 466
      <211> 759
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(759)
      <223> n = a,t,c or g


      <400> 466
 gggatggctg aagagaaaac agtccgtgat aaagagtaca aggcccttca aataaaactg     60
 gaacggttag agaagctgtg cagggctctt caaacagaaa ggaatgagct caatgagaag    120
 gtggaagtcc tgaaagagca ggtatccatc aaagcggcca tcaaagcggc gaacagggat    180
 ttagcaacac ctgtgatgca gccctgtact gccctggatt ctcacaagga gctgaacact    240
 tcctcgaaaa gagccctggg agcgcacctg gaggctgagc ccaagagtca gagaagcgct    300
 gtgcataagc ccccgtccac aggctctgct ccggccaatc gagtcggttg actaagatga    360
 ggtgtgatca ctgaattgag agataaattt tgcggataac tttctctggt agtagntaac    420
 tattgggttt cgtggcgaaa aatttactac tttttctacc ataatctgca ttttcttaga    480
 actactgaac ttatgtggtc caggaggctg cttagcaggc ttgatagtta aatctataaa    540
 atttcctcag ttggggtgcc atgacctcgt tctccttcca ctgaatgcga tgggtccttg    600
 gctgtgcctt ctctcctggt cctggccata tcatccttag agaattactg gcagggcgcc    660
 cattcaggga actttttgtg aagggcctga tgggacatat ataataacac ttaacccccc    720
 ctcatttttt cagaaaaaag aaaaatttat atcgcccgg                           759



      <210> 467
      <211> 426
      <212> DNA
      <213> Homo sapiens


      <400> 467
 tttcgtgggc ttatcagcac gcacaccatg catagctcct taaggacggt gcgacacatg     60
 aaaggtgcca ctgggattct tttcctgctt gtggccccgc ccccaggtat agcatcacct    120
 gcaagtggag gaggtgcgaa ttctacccgc cgttgggtgg ggcagacgac ccctgcccgt    180
 gacggagggg ctggtggaag tcaggctttc tgacagctgg tccaagcgtg cgacccaggc    240
 tgtatcgccc acttacagcc acgtgggctg cggcatgctg ggcttcccca gcgaaaagag    300
 ggtcaacgct ggcttctaca cgcccgtagc cgtctaaagg gcggggctca ccctgtagag    360
 ggccgtgtcc aagttctgaa cggcatcaca tttagcacag tgtgggaccc ccgtgggatt    420
 tattgg                                                               426



      <210> 468
      <211> 1103
      <212> DNA
      <213> Homo sapiens


      <400> 468
 gcggccgcgc cggctccagg aaatggttac tgctgacagg aagtttggca tccacctccc     60
 ccagcctcct gagtggacag gggccctggg caccacttca gagggccatg aagcccccag    120
 gaggagaatc gagcaatctt tttgtgattt ccagaagaag ctactccttc tagcaggcct    180
 aataggatgt catctaatat ttttggacca acagaagaac ctcagaacat actcaagagg    240
 acaaatcccc caggggtata aggaagtggt atctttgacg aatcaacccc cgtgcagact    300
 cgacagcacc tgaacccacc tgggagggaa gaccagcgac atttttgggt ctccggtcac    360
 tgccacttca cgcttggcac acccaaacaa acccaaggat catgtttttc ttatgtgaag    420
 gagaagaacc aaaatccgga tcttaaagct gcaagggagc atcccggctg ggagcagagc    480
 caggtgagaa aggcagcgcc agataaagca ggccccgcca aggagcagga gcccatgccc    540
 acagtcgaca gccatgagcc ccggctgggg ccgcggtgtc actgtgtcta caaggtacac    600
 gacatccctc aaagacgctg actcgatctc taataaaagc tatcagcctg tcccccttta    660
 ctacgagacc cctcttagct ctgcagagca tccatcacag ttaggcattt ttgccctttt    720
 ttccatccac ccacgctttc caccccacca agacgtgagc ttggaactta tcttgtcatc    780
 ccagcagcaa ggagtcgatt ttgcatgatg gatggaaaac acagagagga ccagctgttt    840
 catttctagg cacctcactt ctaacctgga accggttccg agaggaagga ccaggaagac    900
 ccatgtgtcg ggaatggtgg acagaaggag tgtgctcagc tgccgccgag aagaccacac    960
 gctgggtgct gaaaagaggg ggggacctgc taggaaccat ggccctgggc taagtcgggg   1020
 atgaaggcgg gagctgctgt gctggactgc agctcagcac agagacagtg agcctagatt   1080
 gcagagctgc ccagggaagg atg                                           1103



      <210> 469
      <211> 442
      <212> DNA
      <213> Homo sapiens


      <400> 469
 ctccatgctt ggcacgaggt ggtgtaggta gatccggggc aggctcagga ccaagtccct     60
 ctccttccac caaggagcgc ccagaggccg gcgggagctc caggttcacc tcctcctcct    120
 ccaggaaatc ccacttccaa ctggatgtct ggatgaacta ctgaaagctg ctgagtgtcc    180
 tgcagcaggg tcggtggacc tgggtgtctg tctggacaca tcctccagtg gcctggacct    240
 gcccatgaag gtggtggaca tgttcaggag ctgtttgcct gcgtgtgctg tgaacttcaa    300
 gtgacggtaa gggccatgta gaattgagga gcccgctggt gctcccggca ggcagccagc    360
 ctccgcagga ccccgaccag cgacacgatg gcttctgggc aatacagcac gtctacggtg    420
 aaagcttcag gttactgaaa gg                                             442



      <210> 470
      <211> 783
      <212> DNA
      <213> Homo sapiens


      <400> 470
 atggcagaag gcaaaggagg agcaaggcac gttttacatg gtggcaggca agagagcatg     60
 tgcaggggaa ctgcccttta taaaaccatc agatcttgcc tcaagttttg ccctccatta    120
 agaagggaca ccctctttac ggattggtta caggatctaa ttcgcctaca atcaaccctt    180
 gagtcagaaa aagggattga agcatcagta agctctggga aggcttatat ccttggtcaa    240
 cttcagactg ctgtgctggc aggagagctc tggatggcat caggccagtg cccctctgag    300
 acgaagtttc cagaggaagg agcaggcagc aatctttgct gttctgtatc ctccactggt    360
 gataaccagg cgaacaaggt cgggggagtg gaactccagc aaactgctgc agaactgcag    420
 aagaggggcc tgaccgttag aagaaaatct aacaaacaga aagcaacaac atcaacatca    480
 acaaaaagga ctcccacaca aacctccgtc caatcatcat cagcctcaaa gattaaagaa    540
 ggaaaccttg ctcagtggac ttggaaagaa cgtcatttct ttgtgttcaa tgtcaaatac    600
 ccagggcttg gtaaaatgtt agccatatgg gacatggatg aagctggaaa ccatcattct    660
 cagcaaacta acacaggaac agaaaaccaa acactgcatg ttcttactca taagtgggag    720
 ttgaacaatg agaacacatg gacacaagga gggggaacat cacacactgg agcctgttgg    780
 tga                                                                  783



      <210> 471
      <211> 479
      <212> DNA
      <213> Homo sapiens


      <400> 471
 cattaccagc aacaacggca acagatgatg tgcctggagc ggcatataaa accacccaag     60
 gagctggaca cggcctcctc ggatgaggag aataaggacg gagacttcac ggtgttcgag    120
 tgcccgggcc tggccccgac cggggaaatg gaggtgcgca accctctgtt agaccacagc    180
 ccacctgctc cccgacctcg aggcccccgg ggaggggcag ggcctggagc ttcccactaa    240
 aaacatgttt tgatgctgtg tgctttaggc tgggccttgg gctccaggcc ctgggacccc    300
 ttgccaggga gacccccgaa cctttgtgcc aggacacctc ctggtcccct gcacctttcc    360
 tgtttggttt agacccccaa actggagggg gcatggaaaa ccgtagagcg caggaacggg    420
 tgggtaattc tagagacaaa aaccaaaaaa agtccatttc agaaaaaaaa aaaaaaaaa     479



      <210> 472
      <211> 4359
      <212> DNA
      <213> Homo sapiens


      <400> 472
 atggatgaga gtacctttgc aggaggccag gaatatggtg gatgggtccc agaacaccac     60
 aaaagtaacg aacccaagag tggacacatt gaaaaaggta acacagatca gtgccaagaa    120
 agaacccctc aacccatgat ttatcccaca ggggaaattg agagcacagt gaatgcctgg    180
 atgctcagcc atgagaaaga acaaagtcaa atccttttga tatcgaattg ccttgacgct    240
 ttaaagcacc ggagctgtga ttatggtctg aaaatagctc ttgacataaa acacagatta    300
 aagattcagc ccaagatatt tatctataca aggacacata aatatgcagt caccctccac    360
 atgcttgctc ataccattac ctcagaaaga gatgacatag aggaatggtt aaatgcatgg    420
 gtagtagacc agtgctgtcc accagaaatg tctgtgatga tggaaatgtt ctatatttat    480
 gctgtccact atgggagatc acttctttct tggagtcagg aggaggagaa ggagaaggga    540
 ggcagggagg aggaggagga ggaggaggag gaggaggagg aggaggagga ggaggaggag    600
 gaggaggagg aggaggagga ggaggaggca gaagaagaga aattagggga ggcagctgtc    660
 ccggagggtg tccagctcgg atggctgact gctctttcac ttgtcgttaa cttccaccca    720
 gtagtcttag tctccccttg gacatggtac cgaccgtgtg ccattcttat ttcacttgac    780
 cgagcccgag ctgcagccca gggtggaagc cgcaagggct gggcagagtt ccaggcaaga    840
 gggaccgaga ggcgtgagca gtgctccgca gcgcttgtca gagaaatgga gcagcggctc    900
 ctttgtgggc tcttacatcc ccgtcctggg tgcacagccc ggatatttga tctaagcgtt    960
 gcccgttggc tagctgctcg gtggggatct gcctgccctg ggggcgccgc ccgcgctccc   1020
 cgcggtgctc tcgctcctgg gctgcgccag tccgaggcgg tgccggctcc tttgcctccc   1080
 cgagtcgcag atgctgcggg cgcctccggg aaaagatctg ggcggcgcgc tcgctcgtgc   1140
 ccaagtccca tggcgagggc agcccgagtg gccgtcgcgg ctgtaggtcc gcatgccggg   1200
 caccgcacca ggcgtctagc aggtaggggc agggaaggta gggctgcgct ggcggccggt   1260
 gcccagttac cggcgatcgg ggacgctcgg agacacctgg tctcccggaa gcgcccttcg   1320
 gaaatgggat tcgacccggc ttgcgggcgg cgggtgttta gaagaagagg ctgcgggcaa   1380
 gcagtgcccc ctctctggtt ccccggactc ctcttagccc cctcgtggcc tgatgggcgg   1440
 ccgggacgga gagctcatct caagtttgcc cttctctatg gagaaggaaa atttgagtct   1500
 ccagaaggaa agtattttgc taaacgccaa gcaagaatta gaggatggac acaggaagat   1560
 ccagaagcta gtggcacatc tagcaacaga gccagatcag aacccagtgt gttaaccgtg   1620
 gccgggatct tacagacaga gagtcgcaaa actgccaaag acatttgcaa gatccgctgt   1680
 ctgtgcgaag aaaaggaaaa cgtactgaat atcaactgtg agaacaaagg atttacaaca   1740
 gttagcctgc tccagccccc ccagtatcga atctatcagc tttttctcaa tggaaacctc   1800
 ttgacaagac tgtatccaaa cgaatttgtc aattactcca acgcggtgac tcttcaccta   1860
 ggtaacaacg ggttacagga gatccgaacg ggggcattca gtggcctgaa aactctcaaa   1920
 agactgcatc tcaacaacaa caagcttgag atattgaggg aggacacctt cctaggcctg   1980
 gagagcctgg agtatctcca ggccgactac aattacatca gtgccatcga ggctggggca   2040
 ttcagcaaac ttaacaagct caaagtgctc atcctgaatg acaaccttct gctttcactg   2100
 cccagcaatg tgttccgctt tgtcctgctg acccacttag acctcagggg gaataggcta   2160
 aaagtaatgc cttttgctgg cgtccttgaa catattggag ggatcatgga gattcagctg   2220
 gaggaaaatc catggaattg cacttgtgac ttacttcctc tcaaggcctg gctagacacc   2280
 ataactgttt ttgtgggaga gattgtctgt gagactccct ttaggttgca tgggaaagac   2340
 gtgacccagc tgaccaggca agacctctgt cccagaaaaa gtgccagtga ttccagtcag   2400
 aggggcagcc atgctgacac ccacgtccaa aggctgtcac ctacaatgaa tcctgctctc   2460
 aacccaacca gggctccgaa agccagccgg ccgcccaaaa tgagaaatcg tccaactcct   2520
 cgagtgactg tgtcaaagga caggcaaagt tttggaccca tcatggtgta ccagaccaag   2580
 tctcctgtgc ctctcacctg tcccagcagc tgtgtctgca cctctcagag ctcagacaat   2640
 ggtctgaatg taaactgcca agaaaggaag ttcactaata tctctgacct gcagcccaaa   2700
 ccgaccagtc caaagaaact ctacctaaca gggaactatc ttcaaactgt ctataagaat   2760
 gacctcttag aatacagttc tttggactta ctgcacttag gaaacaacag gattgcagtc   2820
 attcaggaag gtgcctttac aaacctgacc agtttacgca gactttatct gaatggcaat   2880
 taccttgaag tgctgtaccc ttctatgttt gatggactgc agagcttgca atatctctat   2940
 ttagagtata atgtcattaa ggaaattaag cctctgacct ttgatgcttt gattaaccta   3000
 cagctactgt ttctgaacaa caaccttctt cggtccttac ctgataatat atttgggggg   3060
 acggccctaa ccaggctgaa tctgagaaac aaccattttt ctcacctgcc cgtgaaaggg   3120
 gttctggatc agctcccggc tttcatccag atagatctgc aggagaaccc ctgggactgt   3180
 acctgtgaca tcatggggct gaaagactgg acagaacatg ccaattcccc tgtcatcatt   3240
 aatgaggtga cttgcgaatc tcctgctaag catgcagggg agatactaaa atttctgggg   3300
 agggaggcta tctgtccaga cagcccaaac ttgtcagatg gaaccgtctt gtcaatgaat   3360
 cacaatacag acacacctcg gtcgcttagt gtgtctccta gttcctatcc tgaactacac   3420
 actgaagttc cactgtctgt cttaattctg ggattgcttg ttgttttcat cttatctgtc   3480
 tgttttgggg ctggtttatt cgtctttgtc ttgaaacgcc gaaagggagt gccgagcgtt   3540
 cccaggaata ccaacaactt agacgtaagc tcctttcaat tacagtatgg gtcttacaac   3600
 actgagactc acgataaaac agacggccat gtctacaact atatcccccc acctgtgggt   3660
 cagatgtgcc aaaaccccat ctacatggca ggaagggaag ggagacccag taggcctatt   3720
 taccgaaacc tggcaaggag tttcagctat taggcaacct ggaggagaaa aaagaagagc   3780
 cagccacacc tgcttacaca ataagtgcca ctgagctgct agaaaagcag gccacaccaa   3840
 gagagcctga gctgctgtat taaaatattg ctgagcgagt caaggaactt cccagcgcag   3900
 gccttagtcc actataactt ttgtacctta cctaaaaggg cagtttgccc ctttcctatg   3960
 gaattttcgg acggccaaaa ccaaggacag gattcaatta aaaccgtttt atatggaact   4020
 cccaggaaat gctttgtggg gcagtcaaaa cccaaccacc ctttactgca agctaagccg   4080
 caatcagaac cggactacct cgaagttctg gaaaaacaaa ctgcaatcag tcagctgtga   4140
 agggaaatca tttacaacac gtaaggcatc agaggatgct gctccgaact gttggaaaca   4200
 aggacattag cttttgtgtt tgtttttgtt ctccctttcc cagtgttaat gggggacttt   4260
 gaaaatgttc gggagatagg atgaagtcat gattttgctt ttgcaagttt tcctttaaat   4320
 tatttctctc tcgctctcct cttcccactc ccacactga                          4359



      <210> 473
      <211> 534
      <212> DNA
      <213> Homo sapiens


      <400> 473
 actcttctgg tccccacaga ctcagagaga acccaccatg gtgctgtctc ctgccgacaa     60
 gaccaacgtc aaggccgcct ggggtaaggt cggcgcgcac gctggcgagt atggtgcgga    120
 ggccctggag aggcacttcg acctgagcca cggctctgcc caagttaagg gccacggcaa    180
 gaaggtggcc gacgcgctga ccaacgccgt ggcgcacgtg gacgacatgc ccaacgcgct    240
 gtccgccctg agcgacctgc acgcgcacaa gcttcgggtg gacccggtca acttcaagct    300
 aagccactgc ctgctggtga ccctggccgc ccacctcccc gccgagttca cccctgcggt    360
 gcacgcttcc ctggacaagt tcctggcttc tgtgagcacc gtgctgacct ccaaataccg    420
 ttaagctgga gcctcggtag ccgttcctcc tgcccgctgg gcctcccaac gggccctcct    480
 cccctccttg caccggccct tcctggtctt tgaataaagt ctgagtgggc ggca          534



      <210> 474
      <211> 1113
      <212> DNA
      <213> Homo sapiens


      <400> 474
 atgagagatg actttagaga agcggcatta cgtcctgaaa agaaaagtgc taagagagaa     60
 gcagaagtac taaagaaaat gggaaaacag gagaaggagc gcagcaaaag aaatatcatt    120
 ggatattttg agcaaaagga ctcggacaac tatagagttt ttgaacgagt agcgaatatt    180
 ttgcatgatg actgtgcctt tctttctgca tttggggatg tttcaaaacc ggaaagatat    240
 agtggcgaca acataatcta caaaccacca gggcattctg ctccggatat ggtgtacttg    300
 ggagctatga caaattttga tgtgacttac aattggattc aagataaatg tgttcctctt    360
 gtccgagaaa taacatttga aaatggagag gagccctcag agacaatcag ggataagtca    420
 ttgactcatt caactgaggc cccgagtggt ggctctgact ttataatgca ggaattagag    480
 cagaaagaag aggcagcggg cgaggaggcc aatgatggag gctcaggcca cagcctaggc    540
 caggaaggcc gaccccgcgc gcagaggact cagtggaccg gggccgagag cccaatggga    600
 aaggaagttc tagatgacgg acgacgtgcg ggcccagtcc cagccgccag cgcctgtccc    660
 tgtcacggac cccagcgtta ccatgcatcc tgccgtcttc ctatccttac ccgacctcag    720
 atgctccctt ctgctcctgg cgcggagtcc ccgaggcctg agaaaccagt gtcgggggag    780
 aatgggagaa ttagccctga gggactgata cgtagtcacg gcgtaggagc ttccccttct    840
 ccccgaagtc cgggggtttc ggtttcgagg gctagtggac ctggtggtag cttgaatcgg    900
 aaaagaccaa gcatagacct agcgttcctt cccaccctct ccatttggga agagtgtgag    960
 gtcgacaggt gctggggttg tgtgactctc actgggtcta gatccctgaa gcggtgcccg   1020
 ggttggcaga tccctctgtt gtggcttgat gcgattggtt gggaaccccg aactggagac   1080
 tggtttggat tccactggga gaatagagtt tga                                1113



      <210> 475
      <211> 1040
      <212> DNA
      <213> Homo sapiens


      <400> 475
 ggcccaggag atttttttta aaagtatttt ttctcccaac atttcccggg tgttccagcg     60
 ccggttttga ccgccacatt accatttttt cacccgaggg tcggctctac caagtagaat    120
 tatgctttta aggcctattt aaccgggggg gcccttacct tcattagctg tcagggggaa    180
 aggactgggc agttattgtt cacacagaag aaaagtactt gaccaaatta tttggattcc    240
 agccacagtg acctcacttt ttccaagata actgaaaaac atttggtggt gtgatgaccg    300
 gaatgacaag ctgacagcag attccagggt acagaagggc acgctattaa agcaagctac    360
 tggaaaatac aaagtatggc tatgaaattc ctgtgaccat gctgtgtaaa ggaattgccc    420
 gatattgttc aggtctacac accagaaatg ctgaaaatga ggccctcttg ggttgtggta    480
 tgattttaat tgggtatagt tgaaggagcc agggcccctc agggtatata aggtgtgaat    540
 cctgccaggt tactactggt gggtttaaaa gccccactgc agcggggagt taaaacaaac    600
 ctgaggtcac cccagcctcc cttgaaaaaa aaaagtgaag gaaggaaatt tggattggga    660
 cattttgaac cagaccagtg gaaactgcca attacattgc ctgttctact gttcttatcc    720
 aattgatttc acaaccttca gaaatagaag ttggagtagt gacagttgaa aatcttaaat    780
 gtcaggattc ttacagaagc agagattgat gctcaccttg gttgctctag gcagagagag    840
 actaaacatt gtctgttagt ttaccgagat ccgtgatgcc acttacctgt gtgtttggta    900
 acaacaaacc aacatcatgg aggtcccctg gattgaaaaa aggagccctc tcccacctcc    960
 tccataacac cgaaaggtgg tttagggctt ttatattaaa taaaaaccag gcctttggaa   1020
 aataaaaaaa aaaaaaaaaa                                               1040



      <210> 476
      <211> 454
      <212> DNA
      <213> Homo sapiens


      <400> 476
 gagaacccaa accagaaatt acatggtggt ttgaaggaga aatactgcag gatggagaag     60
 actatcaata tattgaaagg ggagaaactt actgccttta cttaccagaa actttcccag    120
 aagatggagg agagtatatg tgtaaagcag tcaacaataa aggatctgca gctagtacct    180
 gtattcttac cattgaaact gatgactact agctcccctc ccctctccct ggaactttct    240
 ctttcactcc aactttctta ctacatccat cttttctgtg gcggggccaa aaaaggaaac    300
 caggagtgcc actatgctga cttcttattc cttttcataa cagtcttcaa agcacagctc    360
 atctaaagaa tgcctacttc ttttccaaat aagcatcaga tttatcgcct attatgcagt    420
 aacagtcaat aaaatgtact tatggggggg aatt                                454



      <210> 477
      <211> 904
      <212> DNA
      <213> Homo sapiens


      <400> 477
 tgttttttaa gggggtcatc ccaaaggtct ttgaaggacc aaagatagta cttctaaaat     60
 ttgacagggc ttcattttga ttttttctcc ccaaatagtt gatagcaata atcaatacca    120
 gttgagatac caaagaggca gccctttccc ctgattcccc acacccactt gtaggccttt    180
 gcctagaatg gtcattaata cgtatgaatc agttgagcta aatattattt agaacgtggc    240
 aaaatgctgg ctgtaaatta aatcaaagat aagtaattca aaggctttaa ctgaaaattt    300
 ctgaaaagat gtttgctgtg ctattaaaga tgttaaataa caaaaattaa aagaactgag    360
 aaagactatt ccatgaaagc gcataatagt gaagaaaaaa atgaagttcc cttggcgtta    420
 gccaggtgca tgcaaatctt tttatctgaa tgtagaaatg caaaaagtac caggagaaca    480
 tttctgaaag tagtcaagta tgttttaaca tttatctcct tataatatgc aaactgccaa    540
 actggagtta tgtttttagt tggtaattga tatatatata tatatttgag atggagtttc    600
 actcgtcgca caggctggag tgcagtggca cgatctcggc tcaatgcgcc ctccacctcc    660
 tgggttcaag tgattctcct gcctccacct cccgagtagt tgggaccaca ggcgtgtgcc    720
 accatgcctg gacagttttg gggttttttt gtatttttag tggagacagg gttttgccac    780
 tctgaccagg ctaatctcga acccctgacc tcaggtgatc cgccagcctt ggcctcccaa    840
 agtgctggga ttatttgagg tcaggagtta gtgatcagcc tggtcaacat ggtgaaacct    900
 cggc                                                                 904



      <210> 478
      <211> 903
      <212> DNA
      <213> Homo sapiens


      <400> 478
 agtcaggaaa tggagcacct gttcgtgtac ctccaaagag aacagttaaa agaaatatac     60
 ccaagctgga tgctcagagg tcctttgccg tgtgtactgc gagaatgaag actttttcac    120
 agcaatcaga ctgtcgacca ttcccagaaa aatgtcgaca ttactctgaa agggacgccc    180
 cagtaatcgt gtaagggccc cagagggaac ctctgcggaa gggacttcat tcacatcaaa    240
 tgtggaacct cagcctttct tggaaaagta aaaaaagagg ctcccgggtt tgaccaaatg    300
 gtggggtaac cggaaaggga actggcctac ccgttcggga ctatttggta gtcatgtaca    360
 ggaccatgat ccaaggggtg ttaccactgg ggcttccgtt accaagatga gggtcctgtg    420
 tatgcctcac cttcccccca tccaaccgtt ggtttatccc caggagaatg ggtcctcttt    480
 gttgaaatcc cgaaattttc ttgggtgaaa aaattatatc ggcagggttc ggatggagac    540
 cagggtgttg ctttgttcag tatctcaagg ccaggaaaga tgaattaatc ccttaaagga    600
 aatgacattt gagcttgttt caaatttcag cggctttgat tcagcaagcc ccaccaggtt    660
 aaaaacaagg atatcaggaa aatttttgga tgggatttaa gtttcttgaa aaaggaactg    720
 ttcaaccagg cttgattgaa taagatctaa gaagttacct gggctacaga aagaagatgc    780
 cacgatgaca cttcacgacc tacttgtgat atattaaaag atgcaaaaaa aaacacatat    840
 tagatttgga ccttcttctt aaaaaaaaaa aaaaaaaaaa ctccgagggg ggggcccggt    900
 acc                                                                  903



      <210> 479
      <211> 1714
      <212> DNA
      <213> Homo sapiens


      <400> 479
 cgggagtgcg cacattcgca gcccgggcag ccctgctcgg caccgggcct cgctgcccgc     60
 gccacgccgc ccgcagccgg cctccaagga tcagtgtggt atgtcagcac caggggcgta    120
 caccggtgtc aactttgagg gggccctctt ctctggctat gcacctgacg ggggcctctt    180
 tatgcctgaa gagctcccac agttggacag agagaccctg tgccagtgga gcacactctc    240
 ctatcctggc ctggtgaagg agctgtgtgc cctcttcatt ggctctgagc tccttccaaa    300
 agatgaatta aatgatctga tcgaccgagc cttcagcaga ttccgtcaca gagaagtggt    360
 ccatctgtcc aggttgagga atgggctgaa cctgttggag ctgttgcatg gcgtcacata    420
 tgcatttaag gacctgtccc tgtcctgcac aacacagttc ctgcagtact tcctggagaa    480
 gagggagaag cacgtcactg tggttgtagg aacatctggg gacacaggaa gtgctgccat    540
 tgagagtgtt caaggggcaa agaacatgga cattatcgtt ctgctgccca aaggtcactg    600
 cacaaagatt caggagctcc agatgacaac ggtgctggaa gcagaacgta catgtgtttg    660
 ggagtggagg gaaacagcga ttgagcttcg attgagccga tcaagactgt gtttgccgat    720
 gtggcttttg tcaagaagca caatctgatg agcctgaatt cgatcaactg gtcccgggtc    780
 ctggtgcaga tggcccatca cttctttgct tacttccagt gtacgccatc cttggacaca    840
 catcccctac ccctggtgga ggtggttgtg ccaacagggg ctgccggtaa ccttgcagct    900
 gggtacattg ctcaaaagat aggcctgccc atccgtctgg tcgtggcagt gaaccgcaat    960
 gacatcatcc acaggactgt ccagcaggga gacttctctc tctctgaggc tgttaaatca   1020
 accttggcat cagctatgga cattcaggtg ccctacaaca tggagagggt gttctggctg   1080
 ctctctggct ctgacagcca ggtgacaaga tccctcatgg agcagtttga aaggacccaa   1140
 agtgtgaatc tgcccaagga actgcacagc aagctttcag aggcagtgac atccgtgtca   1200
 gtgtcggatg aagccatcac ccagaccatg ggccgctgct gggatgagaa ccagtacttg   1260
 ctgtgccccc actcagcggt ggccgtgaac taccattacc agcagataga caggcagcag   1320
 cccaggtaca ggcaatgggg gcctgggcca ctgagggacc atttgaattt caggggccct   1380
 cttcttctcc aagcagtggg agagacagga ctacgaaaaa atggctgtaa tggagtgtga   1440
 tgggtgctgt gtggaactgt gccttggaaa ctgtgggccc agaagaggga gcgtgacaga   1500
 tatcccaggg acagccatgg tcagaggtgg tggctgagct ggcctccaac caggaggagc   1560
 agtttgccag gtagcgtcat tgtagcaata agttcaaggt gccaattgtc tgtctgtgtc   1620
 tctgtcctcc ataccccccc atccctaaac ttcctctgtt tcttattcct cctccacctt   1680
 ctcctttccc atctctctat tctctcattg gccc                               1714



      <210> 480
      <211> 2358
      <212> DNA
      <213> Homo sapiens


      <400> 480
 atgagggcag tgtcattgct tgtgttggtt cttggggtca caatgtccta tgtaatgcct     60
 tggcctcaaa ctgagaatta caccatctac ttccctggtt ctgaggcctt caaacttgga    120
 cgagccataa gctcacttcc cagcatccag tatccagggt cttcagctta cagatggcct    180
 gttatggagc ttctcagcct ctataattac gcaaggaggg ccttgatggg caacttagca    240
 aatgtcattc cctgggggtg gtctgagaag atgaccattg agtatttaaa tccggggaca    300
 ggagaacttt taaacaacag ccgaggcgat gcgcctcatt cagaacatgt gcaccatcgc    360
 cgagtacccc gcgccggcaa cgccgcggcc tccgactgct gtgtgggcgc cgcggcgccg    420
 cctggtcaag atcgccgtgg tggggccagc ggcgtgggca agaccgggag ccgctgcccc    480
 ttgggagtgg gcttagccgt tgtctacgcc acccgcctgc ttccacagac gggggaaaca    540
 aggatcaaga atggccaggc agctttctgg ggacaccggc accgccgcca tcagaacttt    600
 ggggtgtttg agcctctgca atgcctggca cagaaagggg agttagtgaa gctagccccc    660
 ctgggaggtc ttgaagcact ggtggtccgg ttcctcacca aacgattcat cggtgactat    720
 gaaagaaatg caggtaatct ctatactaga caagttcaga tagaaggtga aaccctggct    780
 cttcaggttc aagacactcc aggtattcag gtccatgaga acagcctgag ctgcagtgaa    840
 cagcttaata tagtgcattg gctgtgcaca tgctgggggg atggggtact ccatcactga    900
 ctacaagagc tatgaactca taagccagct ccaccagcac gtgcagaagc tacacctggg    960
 cacccggctg cctgtggtgg tcgcggccaa caaagctgac ctgttgcaca tcaaacaggt   1020
 tgaccctcag cttggactgc agctagccag catgctaggc tgctcattct atgaagagtc   1080
 tgtcagtgaa aattataatg atgtctacag cgccttccac gtcctctgta aagaggtcag   1140
 tcacaaacag cagcctagca gtacacccga gaagcgaaga acctccctca ttcccaggcc   1200
 caagtcaccc aacatgcagg acctgaagag gaggtttaag caagccctct ctgccaaagt   1260
 gaggactgtc acctccgtct gaagcaggag gagcactcaa gggggtttgg tcttcccaag   1320
 gaagagggcc tgaggttctc ctagtgcagg aacgttgaat atttggcaat gattcctggt   1380
 tccagaaagg gctggagcag aagggccaag agggcctgtg gaacttgctt acagaaaagg   1440
 aagtgtttgt ttctgagcag ggggacagga tttgattgag gtttgaaaag agcccactga   1500
 gccactctct gaatatgtga aatgtactca tgtgtctttt cctttagagt ggggaggggg   1560
 cataatccgt ttcggtttct gcattcaaac taccttgtaa attggtggtc cgttgcaagt   1620
 ttcaccaaat gtattggatg tgatttacag tgggaatgaa agaacagatt aagcattgat   1680
 aggctttctt ttttccccct tttttctttt ttctcttttc ttctttcttt tcctcttttt   1740
 ccccaagagg aaggaattgc ttttctctta ccagtatgga tttgtaactc tgggaacact   1800
 attcttacag aatgcctttc taacctgaag ggatacccag atttctttct ttatgtacaa   1860
 gatgggaaaa tcccctaccc ctcaaaaaca ggttgagttt atggggccag aatattctgt   1920
 atacccagac cattgggtaa ggctctcatg ggttacaggg aagggctctg ggttcccccc   1980
 ctcacaggga tgaggcatgc ttcagttggg gcgtgtgtgg gagggagctg tggaacttca   2040
 cgctccttca acccccagac ttttgactgt ataggttttt gtttttttaa ctgttcccat   2100
 caggaaaaaa atgtgtcagt tgattttggt gtgacttgtg taaatggttc atggcaatga   2160
 cgttgggttg cttcctaggc ctggctgagt tgtgcctaag ggtggctgaa atactaaaac   2220
 acttattctt acagcaagtg aacaggggct acctgccaca tcccctccac agatgcactt   2280
 taaaaagccc actccatgct ttggcttaaa ctgtaattaa tttattttat gtacaataaa   2340
 tcgcatttga aaaagaaa                                                 2358



      <210> 481
      <211> 343
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(343)
      <223> n = a,t,c or g


      <400> 481
 ctgaactgtt gtaacctttt ggttgtctct tgataaagaa agggcattnt ttgtagcctg     60
 ttcggtgacc gtaccatttg caatgccaac cttgataagc ccaggaggag gtttttcata    120
 aaaggactcc aggcgnttga gtngatgcag ctgcancncg tcgtgccgcc gccgcttctg    180
 ctnccgggcc cgctgcagtt cctgatccag cggtcccgcg gccaccacgc gcccccagcc    240
 ntcgcatcct cgcgccccgg ccaggacgac natcgntgna cctgcggcgc ggcnctgctg    300
 cggccaagag ggcacttcct ccgtgcggcc cncgttccga atn                      343



      <210> 482
      <211> 3672
      <212> DNA
      <213> Homo sapiens


      <400> 482
 atggggtgta caccttcaca cagtgacctt gtaaacagcg ttgcaaagag tggcattcag     60
 ttcttgaaaa agcccaaagc aattcggcca ggatgtcagg gcggaagtga aagaggttcc    120
 atccctttgc tggttaaaaa ctccacctgc tatgacgctg gggagggcct ggcagaggag    180
 cagccaagtc ccaggaggaa ccaaaccaca gctaaaggtc tttgtcagct catgggagat    240
 cctgcttcag gcaaaaggaa agatatggaa ggactgatcc caggaaccaa aacctcttca    300
 tcccagctga acaaatcaca aagccacatg gctaaggata ttccgttcaa gacacagggt    360
 tcccatggat cacaaggggc agacttttct ggagatgaga gtgaggaaag tagtacccaa    420
 gatacttcca aatggaaaag gacagcaaaa tgtcacacgt caagcacaca gagccactgc    480
 taccaaacca tccaccctgc tcatgagcct gaaggcaaag tggacttccc ggagcctctg    540
 gtaaaggccc accagcaggc ttacacctat ctacactcca gcctctccaa atatgaagca    600
 attctgtgca tcatccatca ggccacccag acccgggagc tgctgcagcc catggtcagc    660
 ttcttgctgc tgtgctttga ggagatcagc cagctgttgg gggagatctc caaggatgga    720
 gaagtgctcc tgcaggaagt cagggaggat ctggcttggc ctttgaagaa aagagagccc    780
 caggagcagc caaatctcct gcaacagctg ctacagtaca cagtcagcaa gctgcaggtg    840
 ctcaatggca cagtggcctc gctcaccggc agcttcctgg agggctccag cagctacctc    900
 cactccactg caacccactt ggaaaataag ctgagcacaa aaaggaatgt ggatgaacgc    960
 ctcctgaggg ctctgaggca gctagagagc ctggcgagtg gctgtggcga ccctggggtg   1020
 cagggtctcc ccttatgctc tgaggacagt ggcattggtg ctgacaatga gtccgtgcag   1080
 tcggtggaca agctgggcaa gcaaaccagc tgggaccttg caccagagcc cgaagaatgg   1140
 aagtcggtga cttcacccca cacagaggcc aggcagtcag gacacacctg gcagcaaagt   1200
 ccattctgtt tgggctcagg cagaccccag gactgcctgc tctcaggggc tcctatggca   1260
 aaggttcagc cacgagcaca ggacgaagca aggagcccat gcctctccag tacaagccca   1320
 gaaaatatca cctccccacc tttgaagctg gggacaagca ccccatgtga ttcctttggg   1380
 attggggtct ctgtggaacc acacctttcc aaaacctcca ggccgatgga cgcttcatct   1440
 cttagtgaca gcgaggacag cagcccagag gaggaggagg aagacaaaat gagcagcatg   1500
 agtctgtgtg cctggcagga aaaaactcca cattcaaggc cacaatcttc acctgctgac   1560
 cgggaaagcc catttcaggc ccgcaccagg aggcttagga gcctccaggc ccaggaaatg   1620
 attctgaaga tgaaggagtc aatcagcgaa aggatcaagt ttgtccctgt gccctgtggg   1680
 caccaggact ggtctgagga ggaggagggg aggacagtgg tccccccaag acctagcacg   1740
 gtaagtggca gcaggagggc ccctgagagg cagacgaggt cccagtcaga gtcgtgtctc   1800
 cagagtcacg tggaggaccc cacctttcag gagctgcgaa gggtccagag ggacctcagt   1860
 cagaagctgg aggcatttta tgccctgggt gccaaagggc aggggcagag ccaggagcaa   1920
 attctgcagc ccagagcagc cgccgtgtgg cccaatggca cctgcagggt cagtccaagc   1980
 aacaccacca gcaggctcaa ggcatccctc accaagaact tcagtatttt gcctagtcag   2040
 gacaagagca tcttgcagaa atgcaatccc catcctgagg acgaacaagg caaagctggg   2100
 aagcttccaa atgccatccc atcaggagag gtcagtgagg ctgccaaggc cacagactgg   2160
 aatgtcagag gctgtcccac cagaacatcc gtcaagaagc ttattgaaac tttcagtccc   2220
 acggagagtc tgaggatgct gggggactct aaggacgctg gggcaagtcc ctgcctcagg   2280
 aattgcatca tgccccccag atttcccaag tacacagggc ttgccccttt gtatccgaag   2340
 ccccaaattt ctccagcatc aggcagagaa tctctcaaaa tgggcatagg ctggaagccc   2400
 ttagcaccta tctttccccc tctgcctaaa gcagaagcag ccaagagtga ggagctcagc   2460
 tgtgaaatgg aggggaacct cgagcacctc cctccaccgc ctatggaagt tctgatggac   2520
 aaatcattcg cttctctgga gtccccagaa agcagcaagt ccacagagaa ctcccccaag   2580
 gaaacccagg agccagggcc gggagaggct ggccccacca ggagaacatg ggcttcccca   2640
 aagctgaggg cctctgtgag ccccctggac ttgctgccca gcaagagcac cgccagcctg   2700
 accaagcctc acagcacagg gccagggagt ggcaggagca gctgccagcc caggaagcca   2760
 gccctggacc tgagcagccc accagccacc agccaaagcc ccgaggtgaa gggtgggact   2820
 tggagtcagg cagagaaggc caccagcctc tacaggcagc cccggaaggc catcgcctgg   2880
 caccactccg gccctccatc tggacaaaac aggacctcag agtccagcct ggccagacca   2940
 aggcagagcc gagagagaag cccccctgtg ggcagaaagg cctctcccac gaggacacac   3000
 tgggtgcctc aagcagacaa gaggcgccgg agccttccct cctcttacag acctgcccag   3060
 ccaagcccct ctgctgtgca gacgcccccc agcccacctg tgagccccag ggtgctaagc   3120
 ccacccacca caaagcggcg aacttcccca ccgcaccagc ccaagttgcc caaccctccc   3180
 cccgagagtg cacctgctca gtgcaaggtc cccagccccc caacccagca cccagaagca   3240
 agcccccctt tctcgattcc ctccccatca cccccaatgt ccccttctca ggagcacaag   3300
 gaaacaagag actctgaaga cagccaagca gtcatagcca aagtgtctgg gaacacacat   3360
 tccatattct gcccagctac ctcctctctg tttgaagcta aaccgccact ctcaacagcc   3420
 cacccactga ccccaccatc gctgccgcca gaggctgggg gccctctcgg gaacccagca   3480
 gaatgctgga agaacagctc agggccttgg ctgagagcag actcgcagcg gagagcagct   3540
 ctgtgtgccc tcaaccctct gcctttcctc aggaggacag cttctgaccg ccagccaggt   3600
 ggccgaccgc agcctcccac cttggacccc accagcacct cttatgaatc ccagctcggc   3660
 cagaacaggt aa                                                       3672



      <210> 483
      <211> 395
      <212> DNA
      <213> Homo sapiens


      <400> 483
 tgcgaaggca actccacgtg ctcagagaac gaggtgtgcg tgaggcctgg cgagtgccgc     60
 tgccgccacg gctacttcgg tgccaactgc gacaccaagt gcccgcgcca gttctggggc    120
 cccgactgca aggagctgtg tagctgccac ccacacgggc agtgcgagga cgtgacaggc    180
 cagtgtactt gtcacgcgcg gcgctggggc gcgcgctgcg agcatgcgtg ccagtgccag    240
 cacggcacgt gccacccgcg gagcggcgcg tgccgctgtg agcccggctg gtggggcgcg    300
 cagtgcgcca gcgcgtgcta ctgcagcgcc acgtcgcgct gcgacccaca gaccggcgcc    360
 tgcctgtgcc acgcaggctg gtggggccgc agctg                               395



      <210> 484
      <211> 1044
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1044)
      <223> n = a,t,c or g


      <400> 484
 cgcttaacct gagctgtgct gacgtggtct ggcaccagat ggatgagaac ctgctggcca     60
 cagagccacc aatggcgtgg tggtcacgtg gaacctgggc cggccatccc gcaacaagca    120
 ggaccagctg ttcacagaac acaagcgcac ggtaaacaaa gtctgcttcc accccaccga    180
 agcccacgtg ctgctcagtg gctcccagga tggcttcatg aagtgctttg acctccgcag    240
 aaaggactct gtcagcacct tcttcgggcc agtcggagag cgtgcgggac gtgcagttca    300
 gtatccggga ctacttcacc ttcgcctcca ccttttgaga acgggcaatg ttgcagctct    360
 gggacatccg gcgtcccgac cggtgcgaga ggatgttcac agcccacaac ggacccgtct    420
 tctgctgcga ctggcacccc gaggacaggg gctggttggc cactggaggg cgcgacaaga    480
 tggtgaaggt ctgggacatg accacgcacc gtgccaagga gatgcactgt gtgcagacca    540
 tcgcctcggt ggcccgtgtg gagtggggcc agagtgccgc caccacctgg ccacgtgctc    600
 catgatggtg gacacaacat ctatgtttgg acgtgcgccg cccttcgtgc cagctgcatg    660
 tttgagacac cggacgtcac acgggattgc tggngcaccc cacgaccctc ttctgtgttt    720
 ggtcagacag tcgtggccag cctgttcgga gcagcagccg ggcgcgcacc tgggccttgt    780
 acgccttggg actgctcgcg caagaaccct ggtcgatggg gaagctactt ggacgggccc    840
 cctttttaag aaatggccgc aggcttaact ccctccgcct agttttaaaa caagagggga    900
 ccgtttgtgc aaaaaattct cttgccgcgt gcgttgtaca cagaagggga ttccaaggga    960
 aggcatgtgt tttccctctc ccgcaccaca gaggggtgtg cttctatatc atatcgtgtg   1020
 gagtgccaga gtcaatcttc tccg                                          1044



      <210> 485
      <211> 1044
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1044)
      <223> n = a,t,c or g


      <400> 485
 cgcttaacct gagctgtgct gacgtggtct ggcaccagat ggatgagaac ctgctggcca     60
 cagagccacc aatggcgtgg tggtcacgtg gaacctgggc cggccatccc gcaacaagca    120
 ggaccagctg ttcacagaac acaagcgcac ggtaaacaaa gtctgcttcc accccaccga    180
 agcccacgtg ctgctcagtg gctcccagga tggcttcatg aagtgctttg acctccgcag    240
 aaaggactct gtcagcacct tcttcgggcc agtcggagag cgtgcgggac gtgcagttca    300
 gtatccggga ctacttcacc ttcgcctcca ccttttgaga acgggcaatg ttgcagctct    360
 gggacatccg gcgtcccgac cggtgcgaga ggatgttcac agcccacaac ggacccgtct    420
 tctgctgcga ctggcacccc gaggacaggg gctggttggc cactggaggg cgcgacaaga    480
 tggtgaaggt ctgggacatg accacgcacc gtgccaagga gatgcactgt gtgcagacca    540
 tcgcctcggt ggcccgtgtg gagtggggcc agagtgccgc caccacctgg ccacgtgctc    600
 catgatggtg gacacaacat ctatgtttgg acgtgcgccg cccttcgtgc cagctgcatg    660
 tttgagacac cggacgtcac acgggattgc tggngcaccc cacgaccctc ttctgtgttt    720
 ggtcagacag tcgtggccag cctgttcgga gcagcagccg ggcgcgcacc tgggccttgt    780
 acgccttggg actgctcgcg caagaaccct ggtcgatggg gaagctactt ggacgggccc    840
 cctttttaag aaatggccgc aggcttaact ccctccgcct agttttaaaa caagagggga    900
 ccgtttgtgc aaaaaattct cttgccgcgt gcgttgtaca cagaagggga ttccaaggga    960
 aggcatgtgt tttccctctc ccgcaccaca gaggggtgtg cttctatatc atatcgtgtg   1020
 gagtgccaga gtcaatcttc tccg                                          1044



      <210> 486
      <211> 225
      <212> DNA
      <213> Homo sapiens


      <400> 486
 cataatgccc tcaacatcca gccatgtcgt agaatgggcc aatgtggctt tgtgaagcag     60
 ctggagattc ctcagtatgg ctacagaaac aatgtcccca caactacgcc gcgttccaac    120
 ctggccaagg agctcgagaa atattccaag acctcgtttg aatacaccat taacgacaac    180
 catacttatg ggggactagg gtgcatgaga ccacgcttag tgtga                    225



      <210> 487
      <211> 568
      <212> DNA
      <213> Homo sapiens


      <400> 487
 atgcctcagc aagtacaaaa tcatggaaat cgtaacagtc tctcagacca cagtgcaatc     60
 aaattagaac tcaggattaa gaaactcact caaaaccaca caattacatg gaaactgaac    120
 aatctgctcc tgaatgacta ctggataaat aacgaaatta aggtggaaat aaataagttc    180
 tttgatacca ataagaacaa agacacaacg taccagaatc tctgggacac aggatttcca    240
 atttccaagc ctgatgggct ctcccagctg gaacaggatc tacaggtctt tgatctggaa    300
 actaagacta gagaagtctt aagagatgac ttctcagagt ttaggcaaat aacaatcagc    360
 aaagaagcct tcaccagtga gaagaacaat gaatgtaata aacctgaaaa aagcttcagt    420
 ctggactcta ctattgatgc agatcagaaa gttcttagaa tacagaacac tgatgataat    480
 gataagaacg acatgagctt cagccagaat tcagcctctg gtaaacatga acacataaat    540
 ctaacacagg attttcagag tagtatat                                       568



      <210> 488
      <211> 570
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(570)
      <223> n = a,t,c or g


      <400> 488
 cgccctcgac nccntnnntt tagaacnact atccagaggg tggaattcga ttgggatcct     60
 ggttttcaga aatgattgga gtgatttatg taagttggga ggggtttttt gatggggttg    120
 gtaaggtctt acgttaaagg aaaggtatac agagataaat attggtactt gagtcattag    180
 ctttcaaaga agcctggggt aatggaggaa aggtaagaat tgattctgac agaatcttga    240
 gatgggcaga attaacatct ggaagaggtc acagtgtcct gatttacctt acctgtgtcc    300
 aggatggcca ggccatgtta tgggatctca acgaaggcaa acacctttac acgctagatg    360
 gtggggacat catcaacgcc ctgtgcttca gccctaaccg ctactggctg tgtgctgcca    420
 caggccccag catcaagatc tgggatttag agggaaagat cattgtagat gaactgaagc    480
 aagaagtatc agtacagcag caggcagacc accccaggca cctcctgcct gtctgtgatg    540
 ccaaactctg ttgtgctaca cgacacctgn                                     570



      <210> 489
      <211> 479
      <212> DNA
      <213> Homo sapiens


      <400> 489
 aatagaccgc ttgtagaact ctgacgagcc ggccaggaat tccaggctca caaggctatc     60
 ttagcagctc gttctccggt ttttagtgcc atgtttgaac atgaaatgga ggagagcaaa    120
 aagaatcgag ttgaaatcaa tgatgtggag cctgaagttt ttaaggaaat gatgtgcttc    180
 atttacacgg ggaaggctcc aaacctcgac aaaatggctg atgatttgct ggcagctgct    240
 gacaagtatg ccctggagcg cttaaaggtc atgtgtgagg atgccctctg cagtaacctg    300
 tccgtggaga acgctgcaga aattctcatc ctggccgacc tccacagtgc agatcagttg    360
 aaaactcagg cagtggattt catcaactat ttaggcgctg gcccgaggat atcccagcgg    420
 tggtacttcg gagacacctg tctgcatctg actgagcaga acaaatcgtc aggtgcctg     479



      <210> 490
      <211> 393
      <212> DNA
      <213> Homo sapiens


      <400> 490
 tttcgtgttg tgtctgagcc gagtagtgga aggcggttgg aaggaggtgt agcgtgagac     60
 tggactgccc gcattgggta catgcgcagt gccgctcgcg cgggccgcgc caatcctgca    120
 gcgccttcaa cagtctccac gtacgtccct caaagcgcgt cctaaaaccc ggataaccgg    180
 agcgctcccc atggaccaca cggagggctc gcccgcggag gagccgcctg cgcatgctcc    240
 atcgcctggg aaatttggtg agcggcctcc acctaaacga cttactaggg aagctatgcg    300
 aaattattta aaagagcgag gggatcaaac agtacttatt cttcatgcaa aagttgcaca    360
 gaagtcatat ggaaatgaaa aaaggttttt ttg                                 393



      <210> 491
      <211> 425
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(425)
      <223> n = a,t,c or g


      <400> 491
 aaacacttta agatgagaaa aattgatctc tgtctgagct ctgaagggtc cgaagtgatt     60
 ttagctacat caagtgatga aaaacaccca cctgaaaata tcattgatgg gaatccagaa    120
 acgttttgga ccaccacagg aatgtttccc caggaattca ttatttgttt ccacaaacat    180
 gtaaggattg aaaggcttgt aatccaaagt tactttgatt tggtacacac agaggggcag    240
 cttcaaaatg aagaaattgt ggctcccatc ccaaattatg gaagtactgg gcatctttga    300
 agaccagctc aaatgccacc agctccaaaa agcattgttg gattcaccca gctcagagga    360
 ttgctgtctc ctctgtgccc tctgagcact tagtcttcac tctaacatat actccacctt    420
 gagtn                                                                425



      <210> 492
      <211> 425
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(425)
      <223> n = a,t,c or g


      <400> 492
 aaacacttta agatgagaaa aattgatctc tgtctgagct ctgaagggtc cgaagtgatt     60
 ttagctacat caagtgatga aaaacaccca cctgaaaata tcattgatgg gaatccagaa    120
 acgttttgga ccaccacagg aatgtttccc caggaattca ttatttgttt ccacaaacat    180
 gtaaggattg aaaggcttgt aatccaaagt tactttgatt tggtacacac agaggggcag    240
 cttcaaaatg aagaaattgt ggctcccatc ccaaattatg gaagtactgg gcatctttga    300
 agaccagctc aaatgccacc agctccaaaa agcattgttg gattcaccca gctcagagga    360
 ttgctgtctc ctctgtgccc tctgagcact tagtcttcac tctaacatat actccacctt    420
 gagtn                                                                425



      <210> 493
      <211> 423
      <212> DNA
      <213> Homo sapiens


      <400> 493
 tggtgttcag ttgtggcggt tgctggtcag taacagtcaa gatgctgcgg aatctgctgg     60
 ctcttcgtca gattgggcag aggacgataa gcactgcttc ccgcaggcat tttaaaaata    120
 aagttccgga gaagcaaaaa ctgttccagg aacagcatat gccatatatg agctggctgt    180
 ggcttcattt cccaagaagc aggagtgact tcagtcatcc cagcaatcgc ttggttcagt    240
 ttcattcagc tctctatgga ccagtaatct gataaataac cgagctcttc tttggggatc    300
 aatatttatt gacttggagt aactgccacc aataaagcag tctttaccat gatcaaaaca    360
 ctttacctgc gaggtaaggg ttcatcgtcg caaataattt ctcccctctc taacacatcc    420
 tgc                                                                  423



      <210> 494
      <211> 972
      <212> DNA
      <213> Homo sapiens


      <400> 494
 gcgcctgcgg aattccgcac gagcggagag gctgctggct ctggggaaag gagagagcag     60
 cccagtgtga cagagcgagt ccccacggct ctgggagtgc ctcgcatgtg tgtggcccag    120
 gtcctgacag cccacctact ccctccccgg caggcactgg gctccctctg ctccccgtgg    180
 gccgctcccc gcgtggggcc actgcccccg gcccccgcca tggtgcggat ttcaaagccc    240
 aagacgtttc aggcctactt ggatgattgt caccggaggt atagctgtgc ccactgccgc    300
 gctcacctgg ccaaccacga cgacctcatc tccaagtcct tccagggcag tcaggggcgt    360
 gcctacctct tcaactcagt ggtgaacgtg ggctgcgggc cagccgagga gcgggtgctg    420
 ctgaccggcc tccatgctgt cgccgacatc cactgcgaga actgcaagac cactttgggc    480
 tggaaatatg aacaggcctt tgagagcagc cagaagtaca aagaggggaa gtacatcatt    540
 gaactcaacc acatgatcaa agacaacggc tgggactgac ccccgctccc ccgacgcatg    600
 tggctccagc ccggcctggg ccgccaggga gccgccactg gcttcccgcc acccgaaggg    660
 agctctggac cctcagagcc cctgcagagg acggatctag ctcctgtata tatattttat    720
 tgcatgcact gtgaccttgg ggggagaaca gaagggggac gacgcccccg cacctcctgc    780
 gatctggctg gcttggatct cgtttttaac ccgttcctgc cccacctgcc ctatagttat    840
 ggcctgtgtt ctgctctcct ggtcccagtg caccgtttgc tctgtgaact cctcccacca    900
 ggcccttctt accccacgcg tgtctgtccc cctcgttctg tagcgtttgt acataataaa    960
 acaatggaat gg                                                        972



      <210> 495
      <211> 476
      <212> DNA
      <213> Homo sapiens


      <400> 495
 gcctcccttc tgggatctta gtgcagacag ctgcgaggac tgtcatgatg gcaccagatg     60
 caccaagtga tggtccatat cttcctgtgg caactttacc cacgtaactg acaaaattgg    120
 aaataacact tgaggctgga ttcgatgtga aatatctgat cattgtccgc tgcagagaag    180
 gtactctcca taaacagaat acaaggacat ttgcagctat aatacctgtc acagtccgct    240
 ggccatcact taggttattc caccacttgt taatcccaac agtaaaaaat aaaggtttta    300
 tgagactcct tataggatag ggagaaggat aaaagactgt ttcttccaca ggaggaatca    360
 aagcacttct cttgtatgct tcaccacttg tccctgggtc tgatcttcga ggttcaacct    420
 tcctgggtgc ttttctgaat ccgcattttt gttgaataaa gaagttaaac ctgcgt        476



      <210> 496
      <211> 1026
      <212> DNA
      <213> Homo sapiens


      <400> 496
 tttggggcca gagtgggcga ggcgcggagg tctggcctat aaagtagtcg cggagacggg     60
 gtgctggttt gcgtcgtagt ctcctgcagc gtctgggggt ttccgtgcag gccctcgaaa    120
 ccaggaccct tcgcgtgccc tagccgagtt atggccgacg aaggccgtga tgcgtgctga    180
 agggcgacgg ccccagtgca gggcatcatc aatttcgagc cagaaggaaa gtaatggacc    240
 cagtgaaggg tgtggggaag catttaaagg gactgactga aggccttgca tggatttcat    300
 gttcatgagt ttggagataa atacagcagg cttgtaccag tgcagggtcc tcactttatc    360
 cctctatcca gaaaacaacg gtgggcccaa agaatgaaga gaggcatgtt gaagacttgg    420
 ggcaatgttg actgcttgac aaagatggtg ttgggccgat gtgtctattg aaagattcct    480
 gtgatcttca ctcttcaggg agaccatttg catcatttgg gccgcacact ggtggtccca    540
 tggaaaaagc cagatgactt ggggcaaagg gtgggaaatg aaagaaagtt caaagacagg    600
 gaaacgctgg gaagttcgtt tgggcttgtg gtgttaattt ggggtccgcc cccaataaac    660
 attccccttg ggatgtagtc ctgaggcccc cctaacctca tcctgttatc cccgcctagc    720
 ctgtagaaat gtatccctga taaacattta aacactgtta atctttaaaa gtgtaattgt    780
 gtgacgtttt tcagagttgc tttaaaagta ccctgtagtg agaaactgat ttatgatcac    840
 ttgggaagat ttgtatagtt ttataaaact cagttaaaat gtctgtttca atgacctgta    900
 ttttgccaga cttaaatcac agatgggtat taaacttgtc agaatttctt tgtcattcaa    960
 gcctgtgaat aaaaaccctg tatggcactt attatgaggc tattaaaaga atccaaattc   1020
 aaaaaa                                                              1026



      <210> 497
      <211> 480
      <212> DNA
      <213> Homo sapiens


      <400> 497
 ggcacgaggt ggcggccggg cagcatggcg gggctggagc tcttgtcgga ccagggctac     60
 cgggtggacg ggcggcgcgc cggggagctg cgcaagatcc aggcgcggat gggcgtgttc    120
 gcgcaggctg acggctcggc ctacattgag cagggcaaca ccaaggcact ggctgtggtc    180
 tacggcccgc acgaggcgag tgggcgcgcg ggatggggaa tcgtgtggcc gtgggagctg    240
 cggggcagcc gggctgagcg ctggctcggg gacttgaggg gcaacggccg gcgcgcctca    300
 gtctacacag ccgatgctca gcaccgcatc tcactcggag taaacgcaag tccttagtgt    360
 gctgcgcggt ggtcctgcct ttctcatcgg cctctgtccc tgcgccctcc ttcctctttg    420
 cggctcttca acgtgctagg cactccccca ctcgctccct ctcctttcag ctctactccg    480



      <210> 498
      <211> 791
      <212> DNA
      <213> Homo sapiens


      <400> 498
 ctgagaagac acaggtggaa tccacatgga agaggcccca gaaacctaca ttcccagcag     60
 ggctgtatct ttgttcttca actggaagca ggaattcagg actctggagg tcacactccg    120
 ggatttcagc aagttgaata agcaagatat cagatatctg gggaaaatat tcagctctgc    180
 cacaagcctc aggctgcaaa taaagagatg tgctggtgtg gctggaagcc tcagtttggt    240
 cctcagcacc tgtaagaaca tttattctct catggtggaa gccagtcccc tcaccataga    300
 agatgagagg cacatcacat ctgtaacaaa cctgaaaacc ttgagtattc atgacctaca    360
 gaatcaacgg ctgccgggtg gtctgactga cagcttgggt aacttgaaga accttacaaa    420
 gctcataatg gataacataa agatgaatga agaagatgct ataaaactag ctgaaggcct    480
 gaaaaacctg aagaagatgt gtttatttca tttgacccac ttgtctgaca ttggagaggg    540
 aatggattac atagtcaagt ctctgtcaag tgaaccctgt gaccttgaag aaattcaatt    600
 agtctcctgc tgcttgtctg caaatgcagt gaaaatccta gctcagaatc ttcacaattt    660
 ggtcaaactg agcattcttg atttatcaga aaattacctg gaaaaagatg gaaatgaagc    720
 tcttcatgaa ctgatcgaca ggatgaacgt gctaaaacag ctcaacgcac ttgagctgcc    780
 cctggggctg g                                                         791



      <210> 499
      <211> 952
      <212> DNA
      <213> Homo sapiens


      <400> 499
 tttttaatgt agaaatactt tattgctgaa aaatgctaat gatcatctga gccatcagtg     60
 agtcatagct ttttgttggt ggagaatctt gccttgatat tgatggtttc taatagacca    120
 gggtggtggt tgctgaagga tggagtggct gtggcaattt cttaaaataa gacaacaatg    180
 aagtttgctg catccatgta ctcttctttc catgaacaat ttctctgtat catgcaatgc    240
 tgtttaccca cagtacaact tctttcaaaa ttggagtcag tcctttcaaa ccctaccact    300
 gctttatcaa ctaagtttct gtcatagttt aagtcctttg ttgtcatttc aacgttgttc    360
 gcagcatctt caccaggagt agatctcatc tcaagaaacc actttctttg ttaatcccta    420
 tgaagcaact cctcatccat ttaaatttga tcatgagata gcagcaatct agtcccattt    480
 tcagggttca cttctaattc aagttctctt gctgtttcta ccacatccac agttacttcc    540
 tacaatgaaa ttttgaaact gtcagttata aaagtcagaa tcaacttctt ccagacccct    600
 gttaatgttg ctattttgat ctccttccat gaaacatcag tgtttttatt ggcatctaga    660
 atgctgaatt ctttccagaa gattttttct ttgcccagat tttggatctg ggcaaagagg    720
 ccaggaattc ttcctaacat ctgcaatgcc caggagagct cctccccaac aaaggattat    780
 ccagccaaaa ttgtcaatag tgaaaaggct gagaaatcct atactggaga aagcatgtgg    840
 aaacagagaa gaaaaaaaaa ttaaaagaca gaatgggaac atattaggtc aaaagccaga    900
 ggagtcaagc atacccaatg gctaaaaaaa aaaaaaaaaa aaaaaaaaaa aa            952



      <210> 500
      <211> 2967
      <212> DNA
      <213> Homo sapiens


      <400> 500
 atgaggagag accccacgcc gcccaggggc ctcccgcggc agaggccgac gccgagccca     60
 aggacacgct cccggggaca ccaaagccaa aggccaaagg ccaagtccga gccccagccc    120
 gcgcccgcgg cgacccccgg aggccgaagg gcgtgggaac cacgggcgca agccggctgc    180
 ccacccccgc cccgggccgc ctctcccagg agattagtgc agggcgagcg gccggaatcc    240
 gggaaccgta gccgacaggc agcttaccca cgccgcgcca gccgggcacg aacctgcaca    300
 acgcgacttc caccaacctt gcgccagcgc gcactgacgc agcgcccatg ctcggtaccc    360
 aggaccaata gaaagctccg aaggggacct gggccaatca cattgcgccg ccctgagtcg    420
 tgctcccgcc ccgcgtttgc tacggaggcc cacgacgccc aggcgcttcc gcgaccaccc    480
 ggagtgattg cccggcagag cgcgatgcat agagctctgg ctgctttaaa aaataaacct    540
 ctaaatcatg ttcacaaggt agtcaaggag cgtctgtgcc cttggttgtg ttcacgacaa    600
 cctgagcctt tcggggtcaa attccatcat gcccattgta aaaagtttca ttcgaaaaat    660
 ggaaatgacc ttcatccact cggtggacca gtgttctctc aagtatctga ctgcgacagg    720
 cttgaacaaa atgttaaaaa tgaggagagt cagatgtttt acaggagact gagcaacttg    780
 acttcatcag aagaagtgct aagttttata agcacgatgg aaaccctgcc tgacactatg    840
 gcagcaggag ctttacaacg aatttgtgaa gtggaaaaaa aggatggtga tcaagggctg    900
 ccaaaagaaa tactggagaa tagcatcttt caagctttat gctttcagtt tgaaaaggag    960
 ccctcacagc tgtcaaacac tagtttagtg actgctttgc aagctctgat tctgttgcat   1020
 gtggatcctc aaagtagcct gttgctgaac ctggtggcag aatgccaaaa tcgtctcaga   1080
 aaaggtggca tggaagttcg caatctttgt attcttgggg aaagtctgat tacactgcac   1140
 agttcaggtt gtgtgacact agaactcatt ataaatcaac ttcaaggtga aaaattggaa   1200
 acatttaccc cggaggatat tgtggccctt tatagaatct tgcaggcatg tactgaaaaa   1260
 gtggatgaac accaaacatt tttaaataag ataaacaact tttccctatc aatagtttcc   1320
 aacctgagtc ctaaattgat tagccaaatg ctcactgccc tggtggttct tgatcaaagt   1380
 caagcatttc ctctgattat aaaattgggc aaatatgtcg tgaggcatgt cccacatttc   1440
 actaacgagg agcttaggag agtcttggag gcgttcatat attttgggca ccatgacaca   1500
 ttttttacaa aagccctaga gcatcgtgta gctgcggtgt gcctcacgtt ggatcctgaa   1560
 gttgtctgca gggtcatgga gtactgcagt agagaactga ttctttcaaa acccatcctc   1620
 aatgcagtgg cagaaacttt tgtttgccaa acagaaaaat tttcacctcg tcagatttct   1680
 gccttaatgg aaccatttgg gaaactcaat tatttgccac caaatgcctc tgctttattt   1740
 agaaagctgg aaaacgtgct attcactcat ttcaattatt ttccacccaa atcattattg   1800
 aaacttcttc attcatgttc acttaatgaa tgccatccag tcaactttct ggcaaaaata   1860
 ttcaagcctc ttttccttca acggctgcaa gatgttgaaa ttaaattaga tgaagaagga   1920
 tttgtattgc catccacagc taatgaagat atccataaaa ggatagcact gtgtattgat   1980
 ggtccaaaaa ggttttgctc caatagcaaa cacttactgg ggaaagaagc tattaaacaa   2040
 agacacctac agttactcgg ttatcaagtt gttcagcctc tgctgatcct gtctcatttg   2100
 gctctcccct accctcttca cgtacgcatt cagcagacag ttctgatcac gctgggcaca   2160
 ctcaatgctc cagctctagg gccaaatagg aaagagcccc tgcccttgag gggcttgaaa   2220
 cagggctcct cggacaccaa ggaggcaaga cactccaggg gagactgtga ggccctgggg   2280
 cagtggtcgt acaagttcag gagtcaacaa ctgaaggagc gagcctccac cgagcagaca   2340
 ggagcaagtg atgaaacatg cctccatgtt gatcctctgg ggcaattctt caaggcctct   2400
 ccaggcccct cagaaaggtt catgaccatt caccagttgc cttcagcagt gacctgggcg   2460
 ggggcgctgg acggtggcgg catggaggac gacgaggagg agaccaccgc gtccacgctg   2520
 cggggcaagc ccaggccgcc gcccgtctcg gcgcagtccg ccttcagcta catcccgccg   2580
 cggcgcctgg accccaaaga gcacagctac tactaccgcc cggcgcgggt gaagaaggtc   2640
 tttgcttccc ctttgctttc tgccatgatt acaggaatta tttccctcta tgattgtatt   2700
 tttaagaggc gcctagatta tgatcagaag ttgcaccgag atgacagaga acatgcaaaa   2760
 agcctgggac ttcatgttaa cgaagaggaa caggagaggc cggttggagt gctgacgtct   2820
 tctgtctatg ggaagcgcat caatcagccc attgagcccc taaaccggga ctttggccgt   2880
 gccaaccatg tgcaggctga cttctacagg aagaacgaca tccccagcct caaggaaccc   2940
 ggctttgggc acattgctcc atcctga                                       2967



      <210> 501
      <211> 1227
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1227)
      <223> n = a,t,c or g


      <400> 501
 atgaggaaag agcagaagat ggaaggggac acctatgaga ttatgcaggg tggggggagg     60
 gagcgcacga cgtgcgcgca ccctctcccc tcgtccaccg ctgccgcctc cttcttctgc    120
 cgctcctggt gctgcttgtg tgcctcgttt ggtgcggacc tgcgtacctc ttyttgtgaa    180
 agcggcagct gaggagactc cggcggctcg ccatggcccg acgaaaagcc caaggaagga    240
 gtcaagactg agaacaacga tcatattaat ttgaaggtgg ccggggcagr gatggttctg    300
 ttgtgcaagt ttaagattaa gaggcataca ccacttagta aactaatgaa agcctattgt    360
 gaaccgacag ggattgtcaa tgaggcagat cagattcccg atttgaccgg gcaacccaat    420
 caatgaaaca gacacacctg ctacagttgg gaaatggaag gatgaaagat acaattgatg    480
 gtgttccaac aagcaagacc gggaggtgtc tacttgaaaa agggaacctg cttcctttac    540
 tcccagaact ctgtttcttt ttaaaggacc caagattact gcattctcaa ttaggaaaac    600
 ttgcaatttg ggttccaccc acaatccctg acttacttac cctattagtt ttctcttatt    660
 cttttcattt ccccctttcc cccattcctt tatttgttac ataaagtaac tgggtatatg    720
 tggcaccaag ccatattggc attttttttt ttttttttta actaaacagc caaatggtat    780
 gttttgattg accatccaag tgggagaccc gggatggggg aaaaattact gattctgtga    840
 aaaatacccc cctttctccc attagtggca tgctcattca gctcttaccc tttatattcc    900
 agtaagttat tttgctctca ctgttttaac aaccacaaca aaacaacaac aacaacataa    960
 aaatccttgc ataccttgtt caattggatg aattttaatg tttttcattt atcattgtaa   1020
 aaccaaggac gaattttata acttttttgg tacggtagct gttaccnatg tagggcaatc   1080
 tcgtctttaa gtagggatta aattactcnc taaaacaaaa aagaatccta gatagttttc   1140
 ccttcaagtc aatgcgtctt ggttgtttaa ataaacttct tgtttaaaat gaaaaaaaaa   1200
 aaaaaaaaaa aaaaagggcg gccgctc                                       1227



      <210> 502
      <211> 2085
      <212> DNA
      <213> Homo sapiens


      <400> 502
 gcgaaaactc gcctctgccc aaggctgtgc ggggcgtccg cccccgcact tcgctgattg     60
 gccgcactag cccgctcgtc acgctctttt gtctcagctg gcagaggata aaagccgccg    120
 cggctgcctt aggaacggcg ctgcctcgtc tctgctaccc ctggttgggc ggccctgcga    180
 agcagctcct tcgggcagcc ccgggtcgct tagcggccaa ggaggcttca gttctttgcc    240
 gcctgcaagg cggagaccag aaggcggaat ccacagctgg cgacgcggga gcatctgctg    300
 tccaccagcg gagcacagat accctatcgt cgtcagtcat ggctagcatc attgcacgtg    360
 tcggtaacag ccggcggctg aatgcaccct tgccgccttg ggcccattcc atgctgaggt    420
 ccctggggag aagtctcggt cctataatgg ccagcatggc agacagaaac atgaagttgt    480
 tctcggggag ggtggtgcca gcccaagggg aagaaacctt tgaaaactgg ctgacccaag    540
 tcaatggcgt cctgccagat tggaatatgt ctgaggagga aaagctcaag cgcttgatga    600
 aaacccttag gggccctgcc cgcgaggtca tgcgtgtgct ttcaggcgac caaccctaac    660
 ctaagtgtgg cagatttttt tgcgagccat gaaattgggt gtttttgggg gagtctgaaa    720
 gcagttttga ctttccccat gggtaaattt ttttaacacc cttacaaagc tcaaggggga    780
 gaaagcttcc ctttatgtga tccggtttag aggtgcagct ccagaacgct attcaggcag    840
 gcattatagc tgagaaagat gcaaaccggg actcgcttgc agcagctcct tttaggcggt    900
 gagctgagta gggacctccg actcagactt aaggattttc tcaggatgta tgcaaatgag    960
 caggagcggc ttcccaactt tctggagtta atcagaatgg taagggagga agaggattgg   1020
 gatgatgctt ttattaaacg gaagcgtcca aaaaggtctg agtcaatggt ggagagggca   1080
 gtcagccctg tggcatttca gggctcccca ccgatagtga tcggcagtgc ttgactgcaa   1140
 tgttgataga gataggtgat accctcgacg actccgatga aggatgtgat cctggtggag   1200
 tctcaggacc ctccacttcc atcctggggt gcccctcccc tcagagacag ggccagacct   1260
 caggatgaag tgctggtcat tgattccccc cacaattcca gggctcagtt tccttccacc   1320
 agtggtggtt ctggctataa gaataacggt cctggggaga tgcgtagagc caggaagcga   1380
 aaacacacaa tccgctgttc gtattgtggt gaggaaggcc actcaaaaga aacctgtgac   1440
 aacgagagtg acaaggccca ggtttttgag aatttgatca tcactctcca ggagctgacc   1500
 catactgaga tggagaggtc aagagtggcc cctggcgaat acaatgactt ctctgagcca   1560
 ctgtaaggga ccacccccag gtttcagtga acccttacct atattcagca tccagtagtg   1620
 ggaaaactgg ggtgggggtg ggggtgggac ttctaactgc atgaattaat ccacaaagcg   1680
 gctatctttt ggggtggagt agaaagggtc ttggatacca gcacattgga gggagatagc   1740
 cctgaccctc tggcccctgc tcccttctcc cctgcagccc acgggtctgt tttcctgtgt   1800
 gtgccccatt tcccttgaca gctttattcc tttgtgaaag tggtataatt tattgttaaa   1860
 tatttgaaca ataaaaaagg tacaaaaagt gaagtacaaa ttacccaaat ctctccaccc   1920
 ttatataatc attgtcaacc ctttgatgag tgatatttcc ctatacctat gtacccagat   1980
 agatatatgc atagataaaa gtgatgaaat ataagtgctg ttctatctgt attttttcac   2040
 caaacaatat atgttgtgag cttctatgtc aataaatata tatat                   2085



      <210> 503
      <211> 460
      <212> DNA
      <213> Homo sapiens


      <400> 503
 aaattgggca gggacagggc attctctcca gcaggtgact gggcatgacc actacaatgc     60
 tgatctgaaa ccgatcgatg ggttcaatgg aaggtttggc taccgcagga acactccagc    120
 cctccgtcag agcacgtccg tcttcggaga gagacctgat cgtatggttt ctgtgctcaa    180
 cagaaaactc tctgcagagg aattagagcg aaaacggcaa gagatgatgg aaaacgccaa    240
 atggagggag gaggagagac tgaacatcct caagaggcat gctaaggatg aggaacggga    300
 gcagaggcta gagaagctgg actcccggga tgggaagttc atccaccgca tgaagctgga    360
 gagtgcatct acttcctccc tggaggatcg ggtgaagcgg aatatctact ctttacagag    420
 aacttcggta gctctggaga agaactttat gaaaagatga                          460



      <210> 504
      <211> 460
      <212> DNA
      <213> Homo sapiens


      <400> 504
 aaattgggca gggacagggc attctctcca gcaggtgact gggcatgacc actacaatgc     60
 tgatctgaaa ccgatcgatg ggttcaatgg aaggtttggc taccgcagga acactccagc    120
 cctccgtcag agcacgtccg tcttcggaga gagacctgat cgtatggttt ctgtgctcaa    180
 cagaaaactc tctgcagagg aattagagcg aaaacggcaa gagatgatgg aaaacgccaa    240
 atggagggag gaggagagac tgaacatcct caagaggcat gctaaggatg aggaacggga    300
 gcagaggcta gagaagctgg actcccggga tgggaagttc atccaccgca tgaagctgga    360
 gagtgcatct acttcctccc tggaggatcg ggtgaagcgg aatatctact ctttacagag    420
 aacttcggta gctctggaga agaactttat gaaaagatga                          460



      <210> 505
      <211> 465
      <212> DNA
      <213> Homo sapiens


      <400> 505
 aatgtcataa aatgttgact tactgattcc aaattcatcc attacacttt taagtgatcg     60
 tccagcttca attctactta gaaccttcat tttctcctcc aaattcagtg ttgtatattt    120
 ccctctctta ttcatactga atttaactct gaaccaccag caggagaaaa caaagggaaa    180
 agccttaatg aattggcaaa aaaaaaaacc cacatttttt aaacaaaact tagctgaaag    240
 ccccaaaagg catgggcatt gtattggagg ataatggact gaaggggcta accatgactg    300
 aagagctagt ctagaggggg aggtcttatg cactcaaaaa gctgccagtt gcaaagtcct    360
 gtctggctct tgctcctgca agccatgagt gatcattttt cagaatgccc cctacctctc    420
 ctctcttttg acagatacaa cagcctcagt caggaatgac aggaa                    465



      <210> 506
      <211> 2229
      <212> DNA
      <213> Homo sapiens


      <400> 506
 atgggccatg tgagtagtga cgatgggcac agtgatgagg atgagctgag gaaatccctg     60
 tctgagctgg tggatgacaa gttcgggaca ggcacgaaga aggtgacgcg aatcctggat    120
 ggtggcaacc ccttcctgga tgtcccacag gcgctcagtg ccaccaccta caagcacggc    180
 gtcctgaccc ggaagactca cgctgacatg gatggcaaga ggacgccccg tgggaggcgt    240
 ggctggaaga aattctacgc agtgctcaaa gggaccatcc tgtacctgca gaaggtgaga    300
 gactgcccca gagaccttac tcacccaggg gcctctgact acagcaagaa gtccaacgtg    360
 ctgaagctta agacagccga ctggagggta ttcctcttcc aggcaccgag caaggaagaa    420
 atgctgtcct ggatcctcag gatcaacctg gtggcagcca tcttctctgc cccggccttc    480
 ccagccgctg tcagctccat gaagaagttc tgtcggcccc tgctgccctc ctgcaccacc    540
 cgcctctgcc aggaggagca actgcggtct catgagaata agttgaggca gctgactgcg    600
 gagctggccg aacacaggtg tcacccagtc gagaggggca tcaagtccaa ggaggccgag    660
 gagtaccggt tgaaggagca ctatctcacc ttcgagaaaa gccgttatga gacctatatc    720
 cacctcctgg ctatgaaaat caaagtgggc tcagatgatc tggagcggat tgaggcccgg    780
 ctggccactc tggaagggga tgacccttct ctccggaaga cacattcaag ccctgccctc    840
 agccagggcc atgtgactgg cagcaaaacc acaaaggatg ccactgggcc tgatacttag    900
 ctgacatgga tttgcagacc ccagggtggg cagatgtctc cagtggggtc agtgagcaca    960
 attccagcca ggggccactt ggaccaagct ccagtcagtt gatgggcagc tagaggggtg   1020
 cagaaagcct gtgggcccag gagatggaga tgccgtttgt ggcgttgatc tccttgcgtc   1080
 cttgggcatc tccgggcatc agaccctctc cctggccctt gttttcctct ccaccatgga   1140
 gcctcatttt gtaggccagt ttgtgtgcat gctatagaca ccacctcgct ggagaagctg   1200
 aaagggctgt tgtcttccca ggtctttctc ttctcatcaa gctcctctcc tcatcttttt   1260
 tgtgtgtgag ggcaggtctt gactctaggg tctcagctgg gaaccccacc ctttctcctc   1320
 ctccttcctc tgagttgacc agcagcaggt ctgccgacca ccagcaccat cctctcctcc   1380
 cagcagcctc cagaaccatg cccaggtctc ctgcctcaca tcacaataat ctgggaccca   1440
 ggcttgtgcc ctttcagtgt aaagctgact ccatcacatg tgcatccact tcttttcatc   1500
 cattgagatc acactgcctc ctttttatac agacacaaat atacatctat aagaataata   1560
 tatacataag gaacccctgt aaagatggtt ttggaactgg aatcagttag aggatgaaat   1620
 cagataaagg aaaagcctat tttggagctt cccctgttag gaaggatggc tgcacctggc   1680
 cccctggcat tcctgacgct ctaggaggga agggggaggc agtgctggcc tcccttgccc   1740
 tgtttttccc tcttccagct gacctgtgac ttatactggc tcttacccga tgatactttt   1800
 gggaaaaaat agagcgtgta tgcactgccc cgtttgtccc atgggatatc ccgggggtgt   1860
 taagtccgga tgggtaccac gggccctgtt ttatatttgg ggtctttatg ttggtgctgc   1920
 caggtctctg agctccagag gtggcctctt ggacagatct actgctatag gaataaaaga   1980
 cactctgtct cgcaaatggc cgcttgtcaa caagcccaaa gatgcttgtc ggaggacggt   2040
 tatggaagcc cttaattctt ggttgtggga aaaggtggaa tgacaagtta ttgattgttt   2100
 ttctgtcgct atttctttca tttgtctagt gaatcagaaa ggcttagcaa ggccacatct   2160
 gggaagagtg gagaaatttg ccacttgacg atcacggatt agctagcacc tttaagccct   2220
 gcatttctc                                                           2229



      <210> 507
      <211> 1434
      <212> DNA
      <213> Homo sapiens


      <400> 507
 gctcctctta cagatagtgc ggcggcccaa gcgtcgcgtc tacccggggg attacagtaa     60
 cccggctgtc agtgatgagt cagagagcgg ggggctgatg ctgctgccat ttcatcacct    120
 ttgcgagcgc agcatccatc cctccgctct cccggggcct gggcctaccc agcttcgggc    180
 tctcaggcca gcgatgcgct cgcggctgag ctagatcctg ccgagccgcg ctctctgagg    240
 cgtcggcggg gcgccccctc ccgccgttcc cgggccgggc caaggagacc tgcagagccg    300
 cggccatgga ggccatctgg ctgtaccagt tccggctcat tgtcatcggg gattccacag    360
 tgggcaagtc ctgcctgatc cgccgcttca ccgagggtcg ctttgcccag gtttctgacc    420
 ccaccgtggg ggtgggattt tttctcccgc ttggtggaga tcgagccagg gaaaacgcat    480
 caagctccag atctggggat accgcgggtc aagagaggtt cagatccatc actcgcgcct    540
 actacaggaa ctcagtaggt ggtcttctct tatctgacat taccaaccgc agctcattcc    600
 agaatgtcca tgcatcttgg caagagccca aattacacgt tcaaccctac caaattgtac    660
 ttgttctggt gggtcaccaa gtgtgacctg gatacacaga ggcaagtgac tcgccacgag    720
 gccgagaaac tggctgctgc atacggccat gaagtacatt gaaacgtcag cccgagatgc    780
 cattaatgtg gagaaagccc ttcacagacc tgaccaagag acatatatga gctggttaaa    840
 aggggggaga ttacaatcca ggagggctgg gaaggggtga agagtggatt tgtaccaaat    900
 gtggttcact cttcagaaga ggttgtcaaa tcagagagga gatgtttgtg ctagtcagtt    960
 cttttatttc caaaacatgc tctcctactt gaactgaaaa gtaagagaaa taaatagaat   1020
 ctttgtgtaa ctgatgagaa ctcaacctcc atttggatac caagtgagcc tccctctcag   1080
 ggggactctg acagactcgt gtgcgggtgg atgggggtgc ctgagtgctg tgaccaaggg   1140
 actgaattgc tgacatgggc caggccaggc actgttttgt ggcccatgct aggcagtggc   1200
 tgctccatga gccctttgtg gaccacatgt taaaggcctg gggtttagga agctaagtcc   1260
 caggaaaaca tacctacaga caggacaact gttccttggt atttgagctc acttataggc   1320
 catgaacata aagaaataca taaaggggaa aaaagtttca caatggggac aattagcata   1380
 actaaacaaa gattatgagc tctacttatt ccgtgagaat accctgcacc aaag         1434



      <210> 508
      <211> 441
      <212> DNA
      <213> Homo sapiens


      <400> 508
 ttctgaaaaa caaaaaaaac atttatttct gtaaactgtc tgagtgcaga gatgttcttt     60
 acaatcccaa tacagtacag atttcttccc caaaacgaaa tgagcaagga aaaacagaaa    120
 aagagctata tcaaatgtgc tcatgaagaa ccaagccaat ctcacctttc tttaaaaaca    180
 aaacaaaacg atccttttga ttgtgtggtg cagacgcagg actgaagcca caggcttttg    240
 gggtgctgtg agcccagggc tttgctcagc tcacagctag cgcggcgggc agagcaaccc    300
 ttcggcccaa gccatcctcg cagcttgcac agaagcttcc tgaacctaag ggatccgtgc    360
 agcaaagcca ctgccaggta agttttaagg caaattttat ctcttcttat tcagtctgag    420
 ccggacctaa ccttctcacc a                                              441



      <210> 509
      <211> 456
      <212> DNA
      <213> Homo sapiens


      <400> 509
 aatgggacga tttcgtcgtt tgtgcccggg gtaaccccgt tccgtgccaa gccgcttcag     60
 cgggggacgt acccatgaag gaagagaagg agcacaggcc taaggagaag cgagtaaccc    120
 tggtaacccc cgccggggcc acgggcagcg gtggtgggac ctagggggac agctccaagg    180
 gggagagata agcaggatcg caacaaggag aagaaagaag cgctgagtaa ggtggtaatt    240
 cgaagattac ctcccacttt gaccaaggag cagcttcagg aacatcttca acctatgcct    300
 gagcatgatt attttgagct tttttctaat gatacgaggt tgtatgctca tatggatgcc    360
 cgaagcttac atcaacttta aaaaccaaga tgacattatt ttgttcaagg atcgctttga    420
 tgggaatgaa ttccttggga ataaaggtca agaata                              456



      <210> 510
      <211> 3731
      <212> DNA
      <213> Homo sapiens


      <400> 510
 gaattcggca cgaggagatt atcaaagtga cacctcttca acaaatgctt gcctcatgta     60
 ctggagctat actgacatca gtaatagtga cacccctgga tgttgttaaa attagactcc    120
 aagcccaaaa caacccactc cccaaaggaa aatgttttgt atatagtaat ggactcatgg    180
 atcatctatg tgtctgtgaa gagggaggca acaaactatg gtataagaag ccaggaaatt    240
 tccagggaac attggatggc attttttaaa atcattcgaa atgagggcat taaatctcta    300
 tggagtggcc ttcctcctac cctagtggtg gcagttcctg ccacagttat ttattttacc    360
 tgctatggtt caattaagtg ctcttctgag atctaagtta ggagaaaatg aaacctgcat    420
 accaattgtt gctggaattg tagccagatt tggtgcagta actgtgataa gtccactaga    480
 attgattaga accaagatgc agtccaagaa gttttcttac gtggaactgc atcgatttgt    540
 cagcaagaaa gtatctgaag atggttggat ttccctttgg aggggctggg ctcctactgt    600
 tcttagagat gaaccttttc tcagcaatgt actggtataa ctatggaatt ttaaagaagt    660
 ggttatgtga gaaatctggt ttatatgagc caacatttaa tgatcaactt ttacttcagg    720
 ggcattgtct ggttcttttg ctgctgttgc aactttacca tttgatgtag taaaaacaca    780
 aaagcagaca caactttgga catatgaaag tcataaaatt tctatgcctt tgcatatgtc    840
 aacctggatt ataatgaaga acattgttgc taaaaatgga ttttccggat tatttccagg    900
 ccctaattcc tcggcttaat taaaattggc tcctgcttgt gccattatga tcagtacata    960
 tgaatttgga aaggcttttt ttccagaaac aaaatgttcg aaggcagcaa tactagtgat   1020
 gctgtttcaa cttgaaacaa caacctatag ccaaagaaga atggagactc ttaaggcaag   1080
 aatggttttt caccattaat tctctcacaa atgattttat gtctttcttt cctataattt   1140
 aaataaacca tttcagctct acctctaaat cataatggta aaataacttt tgtcttattg   1200
 ttggtgatat tgaaaaagat attgtagaaa tcacccccat tgagcattct tgtaaaaata   1260
 gattcctcct tagcatcaaa agcagtctct tgaaagttta atattatatg tttcagtgta   1320
 acataatctt actgggagtg tgttgaatac gccagaactt tttgaattgt gtgctgaatg   1380
 atgtacatag tctagaagaa aaaagcccaa gtcttgtgca catttaaatc gtgtacataa   1440
 gtatttccgt atttcagtaa agtagataaa gcactcgtta aatagcattg tttacatcga   1500
 ccaaatattg cctgtttcct ttaattcaaa tgcattaggt tcccgcctcc ctctccttcc   1560
 ccgccatgtt gctgttttaa ggcttcatat gtattaacat ttctctgatc aaaattgtgg   1620
 ctgttttcct tatgaaccat aatataatca tttgtgtgat gtacattgtg ccatttttga   1680
 tgactaaatg tctatatttt tgccattcct gtaagagagg gagttttttt actgatagta   1740
 gcaaatgttc acttcagtca aacttgggtg ttcagtggta aaccatatag tatttagact   1800
 ggtaaaaata gtttgcacac aggaatagcc tctgattttt agctctcttg taatccaagt   1860
 atcattgttc atggaattct ctaggtcatt tttattgtgt tgttctaaca agacagatta   1920
 ttgctacaac aatagttaca agacatttct aaaatatcct ttgattttta ctctaagtat   1980
 ggtagagtaa gaggctaaac aagaagctgt ttccttgaag acattgcttt cagtcaccat   2040
 acatgtctaa ataatttagc ttatcattca ttctatgtag gaatgagata agaaaggata   2100
 tgatggcagg aaaagaaatg ctattcattt tttatacttt agttttattt tcctagggat   2160
 ctatatccta tatatatata ttttttaaag cactaattta ttgcagtctt tattttagaa   2220
 aaatgtgaag catttttttc tcccctaaaa tgaatatatt tagatgacaa gtctttagtg   2280
 ctggtagagg aactaattga ttttgtacta tagtaggaaa gtgtttatat gtttcaccag   2340
 aaataaaata tgtagggttt gtatgtaatc ttctgtgttt atcctatgtt gatttacctt   2400
 aaatttgcaa catacatatc ccacataaat attccatgac tttcttatat ttcattaaaa   2460
 tgttttatgg cttccttaaa atcatcactg tgcttcctaa atatttttac gtaaaatcat   2520
 tgtataatgc tatactgtga tatacatgaa agtttatctt gaccagtgct ctttaccaat   2580
 attaaattta aattttattt gggttttgct atgcttatgg gtaattcata gaaaacagaa   2640
 aaaatactgt tcccaaaagg cagttatata tttcagttta atatcaccta taagtatgag   2700
 aaaggtttcc atgtctccta cccctcactg cacttaggaa aattcttatt tatgaataaa   2760
 gtaagataag taaatctaat tgcctagtcg tttttttaac acatatacat gcaatgtatc   2820
 tggatgaata gaaggctgaa ttgaagcttt ctttatattt aagaggtaaa aagaaatatt   2880
 aatactttta aaatatacta acaaccaaaa agtgttcaga attttgctat agtaataatt   2940
 tgtattaaaa tagtacctag aaaaattcag tctatggaat aggtaaaatt ttaaaatttt   3000
 aatttgctct cagagttctg tctgataaaa taattgaact ataattggca tgatgaatat   3060
 tcccaggttt tacttcagta tataaattta actctcagcc acatgggctt tccagacttt   3120
 tcaatacata tgatgttgca ggaattgcaa tatttgcaaa catgtgccac aacagtgttc   3180
 ttgtgtgatg tttctaaaac agtttttatt ctattaatgt taaattttct aacataaaca   3240
 tttaattgat taatgtaaaa ttttaggaag gaacatcttt aattttcaat atgagatggt   3300
 tgcaaccttt aaagtagtac atatttgatt ttttttaaaa ggcaatattt ttttttctag   3360
 gaaaactatt cattatggtt atttaactgc atatgttttt taaatttttc cctctcggaa   3420
 caacatgtac tggggcctat caaagggtgg agggtgggag gagggagagg aacaggaaaa   3480
 ataactaatg ggtactaggc ttaatacctg ggtgatgaaa taatctgtat aataaatccc   3540
 catgacacaa aagtttacct gtgtaacaaa cctgcatatg tacccctaaa cttaaattct   3600
 tccctctttt tgtcttgggc acaagttttt gggatatgga aaagtttatt gtatcccttt   3660
 tgaattttct tctaagatga actttttaaa taaaagatat tactgctttt aaaaaaaaaa   3720
 aaaaaaaaaa c                                                        3731



      <210> 511
      <211> 3562
      <212> DNA
      <213> Homo sapiens


      <400> 511
 atgttacatc atccttccca aggattccgc tttggaactg tccgagaaag cagtgctgaa     60
 gattatgtga gacaaagttt cccagagatg catgaatata tgagaaggta caatgttcca    120
 gccacccctg atggagtgga gtatctgaag aatgatccag agaaactaga cgccttcatc    180
 atggacaaag cccttctgga ttatgaagtg tcaatagatg ctgactgcaa acttctcact    240
 gtggggaagc catttgccat agaagccttt ttctttcttc tgagtcagga aaggggtgct    300
 gatgaggcaa gattccgaac atttgtggat tcctggccgt atactactgc tcatgacatg    360
 gattctttag aatttagtga tccatctcat catcttgact gcccattggg aaagacgctc    420
 aatctctacc catgtggatt ttcttggaat tcctgtaagc tccaagggct cccacttcac    480
 ggaatgaaat gtgaagtcca cttggggcca gttaattctt tccaagatag tcaaggtgtt    540
 ccactgccag gcaccaggaa cacttgtttc cctggtgttg accatcttac ttcatttaca    600
 ggaaaacgac tgtcttcttc tgccaaaatg tcaggaattg gaaataaaag agcagctgga    660
 gaacctggca cctccatgcc tcctgagaag aaggcagctg ttgaagattc agggaccaca    720
 gtggaaacaa ttaagctagg aggtgtctct tcaacggagg aactagacat tagaacactg    780
 caaaccaaaa atcgcaagct ggcagaaatg ttggatcagc ggcaggccat tgaagatgaa    840
 cttcgtgagc acattgaaaa actggaacga cgacaggcca ctgatgatgc ctcactattg    900
 attgtcaacc gatactggag tcagtttgat gaaaacatcc gtatcatcct taaacgttat    960
 gatctggagc agggcttggg agacctactc acagaacgaa aagcccttgt tgtgcctgaa   1020
 ccagaaccag actctgatag caatcaggag cgtaaagatg accgagagag aggcaagtgg   1080
 gaagggcaag agccagcttt ctctttcctt gctactttgg ccagcagttc cagtgaagag   1140
 atggagtctc agctgcagga acgtgtggag tcttcccgcc gagccgtgtc ccagattgtg   1200
 actgtttatg ataaattgca agaaaaagtg gagctcttat cccggaagct aaacagtgga   1260
 gataatctga tagtggagga agcagtgcag gagctgaact ctttcctcgc acaggagaat   1320
 atgaggctac aggaattgac agatcttctt caggaaaagc atcgcaccat gtctcaggag   1380
 ttctccaagt tgcagagtaa agtggagaca gccgaatcac gagtgtctgt cctggagtcc   1440
 atgattgatg acctgcagtg ggatattgac aaaattcgaa agagggaaca gcgactcaac   1500
 cgacacttag cagaagtcct agaacgggtg aattccaaag gttataaggt gtatggagcg   1560
 gggagcagtc tgtatggcgg cacaatcact atcaatgctc ggaagtttga ggaaatgaat   1620
 gcagagcttg aggagaacaa agagttggct cagaaccgtc tctgtgagct ggagaaactt   1680
 cggcaagact ttgaggaggt cactacacaa aatgaaaagc tgaaggtgga attgcggagt   1740
 gcagtggagc aagtcgttaa ggaaactcca gaatatcgct gcatgcagtc acagttctcc   1800
 gtcttgtata atgagagcct acagttgaaa gcacacttgg atgaggctcg gaccctgctt   1860
 catggcacca gaggaaccca ccagcaccag gttgagctta ttgagcgaga tgaggttagt   1920
 cttcataaga agctgaggac tgaagtaatt cagctagaag atacattggc ccaggtccgc   1980
 aaggagtatg aaatgctgag gatagaattt gagcagaccc ttgctgccaa tgaacaagca   2040
 ggccctataa acagggagat gcgccacctc atcagtagcc tccagaatca caatcaccag   2100
 ctgaaagggg aggtcctgag atataagcgg aaattgagag aagcccagtc tgacctgaac   2160
 aagacacgcc tgcgtagtgg tagtgccctc ctgcagtccc agtctagtac tgaggacccg   2220
 aaggatgagc ctgcggagct aaaaccagat tctgaggact tatcctccca gtcctcagcc   2280
 tcaaaggcat ctcaggagga tgccaatgaa atcaagtcta aacgggatga agaagaacga   2340
 gaacgagaaa ggagggagaa ggagagggaa cgagaaagag aacgggagaa ggagaaggag   2400
 agagaacgag agaagcagaa gctaaaagag tcagaaaaag agagagattc tgctaaggat   2460
 aaagagaaag gcaaacatga tgatggacgg aaaaaggaag cagaaattat caaacaattg   2520
 aagattgaac tcaagaaggc acaggagagc caaaaggaga tgaaactatt gctggatatg   2580
 taccgttctg ccccaaagga acagagagac aaagttccag ctgatggcag ctgagaagaa   2640
 gtctaaggca gagttggaag atctaaggca aagactcaag gatctggaag ataaagagaa   2700
 gaaagagaac aagaaaatgg ctgatgagga tgccttgagg aagatccggg cagtggagga   2760
 gcagatagaa tacctacaga agaagctagc catggccaag caggaagaag aagcactcct   2820
 ctctgaaatg gatgtcacag gccaggcctt tgaagacatg caggagcaaa atatccgttt   2880
 gatgcagcaa ttgcgggaga aggatgatgc aaatttcaag ctcatgtcag agcgtatcaa   2940
 gtccaatcag atccataagt tgcttaaaga agagaaggag gagctggcag accaggtgtt   3000
 gactctgaag actcaggttg atgcccagct acaggtagta aggaaactgg aagagaagga   3060
 gcatctgtta cagagcaaca ttggcacagg ggagaaagag ctgggtctta ggacccaagc   3120
 cttagagatg aataaacgca aggcaatgga ggcagcccag cttgcagatg acctcaaagc   3180
 acaactggag ttggctcaga agaagctaca tgattttcag gatgagatcg tggagaacag   3240
 tgttaccaaa gaaaaggaca tgttcaattt caaacgagcc caggaggaca tctctagact   3300
 tcgcaggaag ctggagacca caaagaaacc agacaatgta cccaagtgtg atgagattct   3360
 gatggaagag attaaggatt acaaggcacg cttgacctgt ccgtgctgta acatgcgtaa   3420
 aaaggatgct gttcttacta agtgttttca tgtcttctgc tttgagtgtg tgaagacacg   3480
 ctatgacacc cgccagcgca aatgtcccaa gtgtaatgct gcttttggtg ccaatgattt   3540
 tcatcgcatc tacattggtt ga                                            3562



      <210> 512
      <211> 467
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(467)
      <223> n = a,t,c or g


      <400> 512
 tagtgccatt agaaaccgca ttttcctacg tgaaggctga caatcactat gaacaaatta     60
 ttactatgaa catacctcta tttttgcagt taacctctca atttcagacc gatcttccct    120
 gtgatttttg gtatttcctg ttcacggatt ttcaagcaag tttttagagc atgtgtacgt    180
 ccttcccatt cagatttttt atgagccacc attatgtcaa tctgtttcat gagctcctgt    240
 agttctgctt cgcaagatgt caaaaatccc ccaccatgcc ctcgattttg tattccttct    300
 aacaaagcct ccatcaccaa atcccctttg ttttggcaac tcgggccggc gctgcgcaca    360
 aacgccacaa aaggctttcg tccagcctct cgaaatcgtc gacccggaat tccggtccgg    420
 tncggcgtgc tgacgcttac aaataatctc tttnnntngg ggggggg                  467



      <210> 513
      <211> 996
      <212> DNA
      <213> Homo sapiens


      <400> 513
 atggcggcca caccccctca tcgcgcggga cccaacccat gcagacacag taggcacctc     60
 agcgagggac gcgaggagac gcgcacacac ccacactcac cacacaccca cggagggggt    120
 gtggaaggcc ccgctccccc ggcatctcgg ctgcagcggg acaaggtgac acatccggga    180
 gcccggcagc gcgccgggtg tgcactcacc cgggcccgcc gcccgcgagc ctcggacgcg    240
 ggcagcagca gcagcagccg ccgccgccgc cgccgccacc tccggccctc cacgtcagcc    300
 gacggcggga gggagcgggt ggcggcgttg aagcgagtac tttacctcgt gtgggccttt    360
 attcctgaat cttggctaaa ctctttaggt ttaacctatt ggcctcaaaa atattgggca    420
 gttgcattac ctgtctacct ccttattgct atagtaattg gctacgtgct cttgtttggg    480
 attaacatga tgagtacctc tccactcgac tccatccata caatcacagg tcatgaaagg    540
 aacaccaatg ttttgcaaac tatgggcagc agtgtttttg agggtcatga tcagtttagt    600
 gttacagtca caggggaccc tatggccagg gctggaagaa gccagctaga gcctcacagt    660
 gactcagatg ccacactcca attgcactgt agtcagccca cttgtgtcat aaagcctgtt    720
 tacacaaagc ctagcatatt agaagcagct gtgagtcagc ctgcttcagc tgctgctgct    780
 gccccaagag gcccatctct ccctgtgata ctttggtttc taaggcaacc tcttttgaat    840
 gttctcagtg aatgcaccat gggtgggcac atcctgggga aagttcagtc actcactcct    900
 caccaccatt ctgtgaagga tttacgcacc tggcaagaat taaaatgcag tgtctacctt    960
 attgctgatg gagcccgatt ttcaagtgct gcataa                              996



      <210> 514
      <211> 380
      <212> DNA
      <213> Homo sapiens


      <400> 514
 ccgattcgcc gtgtggcggg tacgatttcc gccttttgac tctggcctct aggccctgag     60
 ccccgggcgg gctgcatttg tcggggaaac ctttcctcga ccaggggcac ctctactcga    120
 ccaggggcga cggcggactt tgggcttcat catggaggac tacctgcagg gttgtcgagc    180
 tgctctgcag gagtcccgac ctctacatgt tgtgctggga aatgaaacct gtgatttgga    240
 ctacccaggg gctgctcttg ccctggcttt ttacctagca aaggaaccat catcctggac    300
 tgtgtcaaca aggaccttaa aaatggaaag gcaaccccaa aggacagtaa atatgtggag    360
 aaactaaaag cccttttttc                                                380



      <210> 515
      <211> 859
      <212> DNA
      <213> Homo sapiens


      <400> 515
 cgactacaga aacgctatgt attagaggaa gctgagcaac tggagcctcg agttaatgct     60
 ctggaagagg acatggatga tgtggagtcc agtgaagagg aagaatagga ggatgagaag    120
 gtggaaagag tgccatcacc tgatcaccgc cggagaagct accgagactt ggacaagccc    180
 cgtcgctctc ccacactgcg ctacaggagg agtaggagcc ggtctcccat aaggcggagt    240
 cgatctccca aaaggagaag ccccttccct cgccgagaaa ggcatcggag caagagtctc    300
 aagacgtcac cgcagcaggt cccgagatcg gaggcacaga tcccgttcca agtccccagg    360
 tcatcaccgt agtcacagac acaggagcca ctcaaagtct cccgaaaggt ctaagaagag    420
 ccacaagatt agccggagta gggaatgagt aatggactca gtttggtttt agtccacatg    480
 gcctcctgtg gatataagga tatctgtatg tggaaggatt aagatctccc ccaggcagct    540
 ataagaatat tttagttttt ttcttatcaa gtttctcaac ctttattttt aatgaaggag    600
 gtgctgagtt ttgtatcttt ttaatcataa tcaacatcag tttttgaccc aactaacctt    660
 gactgtattc aaactttatg gggagtataa aggatctgga ggttggggat atgactgaca    720
 aggaaaggct gtggccacat gatgacacct tttctcattt ttaaaaaacc ggacacacat    780
 gttacccatt tcgctgtagt ttagtttttg gtttgttgtg gttggagctg ctttgagaat    840
 catgcgcgtg gcgaaatcc                                                 859



      <210> 516
      <211> 303
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(303)
      <223> n = a,t,c or g


      <400> 516
 cctagcctaa aatgaaatgt agtttgcctn tcttgtgatt tgaagagaag cagcagtctt     60
 tacttttcca gccaaatcca gtagcagaat catcttccac aacaaggaat taaaggcgga    120
 gggatttctc tttcctgagc tcaccaaact tattccagtg ttgnatcgca agctgttgat    180
 gcacaggcgt cttgtggcaa gcccagcntc agtttatgtt agacaatcag tacacatgct    240
 ggtgtgtttt ccaatggcca gtgataagna attaaataag tatttgtgag atttgctatt    300
 ttt                                                                  303



      <210> 517
      <211> 2782
      <212> DNA
      <213> Homo sapiens


      <400> 517
 tgcggccgca atagtacgct cgcgcggcgg tggcgggtgg tggtccttgg aacgcggtgg     60
 gcggacagcg gcacggcctc ccctcccctc cggacgcaag ccgaagtacg tgagaggaga    120
 cttccggcca ctgcgttgta gtcggcccgg ctgcaaagcg tttttctgca ggctgttttc    180
 ccaggttccc tcggcctgta cctcgcgcac tcctcattgc tccaggtcct tcagtctccg    240
 ctcgtctcac cgtaggctgt gacgacatga gcaacaaaga aggatcagga gggttcagga    300
 aaaggaagca tgacaatttc ccacataacc aaagaagaga agggaaggat gttaattcat    360
 cttcacccgt gatgttggcc tttaaatcat ttcagcagga acttgatgca aggcatgaca    420
 aatatgagag acttgtgaaa cttagtcggg atataactgt tgaaagtaaa aggacaattt    480
 ttctcctcca ataggattac aagtgctccc tgatatggaa gatatattga ctgaatcaga    540
 aattaaattg gatggtgtca gacaaaagat attccaggta gcccaagagc tatcagggga    600
 agatatgcat cagttccatc gagccattac tacaggacta caggaatatg tggaagctgt    660
 ctcttttcaa cacttcatca aaacacgatc attaattagt atggatgaaa ttaataaaca    720
 attgatattt acgactgaag acaatgggaa agaaaataaa actccctcct ctgatgcaca    780
 ggataagcag tttggtactt ggagactgag agtcacacct gtcgattacc ttctgggagt    840
 ggctgactta actggagaat tgatgcggat gtgtattaac agtgtgggga atggggacat    900
 tgataccccc tttgaagtga gccagttttt acgtcaggtt tatgatgggt tttcattcat    960
 tggcaacact ggaccttacg aggtttctaa gaagctgtat accttgaaac aaagtttggc   1020
 caaagtggag aatgcttgtt atgccttgaa agtcagaggg tcagaaattc caaaacatat   1080
 gttggcagat gtgttttcag ttaaaacaga aatgatagat caagaagagg gcatttctta   1140
 gaatctaacg ttactcagtt actaattctt ttgagaactc ctaagagacc aatttgtaag   1200
 acttatttag tatttcattt aactttattg tggcttttac atagaaacat attcagttgt   1260
 acttgtttta aattgtatac aagctgtaca taaaattagc caaatgaatc atttcttata   1320
 tcttattcat gaaagtttgc atacagatgt ttgcatatat gcctttttga atttttgctg   1380
 gttaaccttt atcatttatc tttgtaatgg gaacatgctt cagagtgtac cttttgccat   1440
 aacctatttt aatttacttt ttctgaaggt tggagtgata atttttagtg gaagcaattt   1500
 gtaatttaag ttggtagtta tattatatat agaaaagatt ttttagttaa acttctggac   1560
 atgagcgtcc tgtttaaatt tcttgttaat atcgcgccaa gcctcaaaaa taggcttatt   1620
 ccatggaaca agaattaaaa atgaataagc tatcaatata taatttaagt acaagtttag   1680
 gctgggcgtg gtggctcacg cctgtaatcc cagcactttg ggagggccga ggtaggcaga   1740
 tcacgaggtc aagagatcaa gaccagcctg accaacgtgg cgaaacctcg tctctactag   1800
 aaatacaaaa attagctgga tatggtggta tgtgcctgta atcccagcta cttgggaggc   1860
 tgaggcagga gactcgcttg aacctgggag gcagaggttg cagtgagccg agattgcgcc   1920
 actgcactcc agcctgggta acagagcaag actccatctc aaaaaaagaa agaaagaaaa   1980
 aagaaagtac aagtttataa agtattatag tgaaaaattc gcattctggc tgattttaag   2040
 ccatttaaaa tttatataaa acaaccttcc ataaaaattt gacaggtgcc cagatgttgc   2100
 tttctccatt tattttttgt ttttttttaa tcacagtagg tctgatagag aattggagct   2160
 aaattataat atttttgttg gtaaagttga gttatatact tgtacataca atggaaatgc   2220
 ttttagctag ctgattattt agcaattttt gtttttgtta tattaggcat gtttggaggc   2280
 tttcctattc tagcatttaa atttaaattt tattaaaatt aaataattta aatctagcat   2340
 ttaaatttaa ataatttaag tctagcattt acttttaaat aattataaat gaagttttga   2400
 aatactaagg tgaatccaga cctttagttg tcccatgggt gttaattaaa gttgccaaag   2460
 aagatgtatt atggaaccaa ttcagcaata agacaattgt ccaacacagt tggagaataa   2520
 caatgggtaa ccgttagtaa atatttagaa ttggaatttg cctactgaaa tagttataga   2580
 tgattacttg tgatgtgaaa ctgaattgag catgacaacc agacatttcc agttggtttt   2640
 gtaagttttg agaatctaga tactgggttt tattttttga aagattagct ctgtttgtaa   2700
 gggctgattc cttgaaaatg taattttcca gaaaaacacc taaagaaaat aaaacatgga   2760
 catgcctagt aaaaaaaaaa aa                                            2782



      <210> 518
      <211> 497
      <212> DNA
      <213> Homo sapiens


      <400> 518
 gcatggacca tgagtttgtt gctaagggac atttgttccg taagggcatc atgaagatta     60
 tggtgtacaa gattttccgc atcctggtgc cagggaacac agacagcact gaggccttgt    120
 cactctccta tctcgtggaa ttaagtgtgg tagcacccgc tgggcaggac atggtctctg    180
 atgacatgaa gaacttcgca gaacagctaa aacctctggt tcacctagag aaaatagacc    240
 ccaagaggct catgtgacta agaggatctg tccacatttg gggcctatcc ttacttgttt    300
 gaaaaaatat gtttgcactc cagcctgggt gagaagagcg aaatccgtct caaaaaaaaa    360
 taaaaatgaa gaggggaaac cagaataaat tatcttttgg aaaggacaat ttcttgtttg    420
 gccatttgtg tataaggttg gtaacattag aggctgtgag cttgtgttac atggtaataa    480
 agccaatgaa gagaaaa                                                   497



      <210> 519
      <211> 1185
      <212> DNA
      <213> Homo sapiens


      <400> 519
 cccacgcgtc cggggaatac ttccaagttg tagtgttgtt gttttcagcc tgctgctgct     60
 gctgctgttg cggctagggg aaccgtcgtg gggaaggatg gtgtgcggag aaatgtgaaa    120
 agaaacttgg tactgttatc actccagata catgggaaag atggtgctag gaatacccac    180
 agaaaattgg tggaagaaag ctgaatgaaa ataaagcttt gacttcaaaa aaaagcaaga    240
 tttgatccat atggaaagaa taagttctcc acttgtagaa tttgtaaaaa gttctgtggc    300
 accaaccagg ttctcattta ctgccagcgg ctgtgcctac aaaaaaggca tctgtgcgat    360
 gtgtggaaaa aagggttttg gataccaaaa actacaagca aacatctgtc tagatgtatt    420
 gatggaattt ctggctttct aaatgatttt actttcttgc cttgaatttt caaggcatag    480
 atgtcaactt aacagataac atggttttaa gataaattaa gtttaaacca gagaatttga    540
 ttgttactca ttttgctctc atgttctaaa cagcaacagt gtaactagtc ttttgttgta    600
 aatggttatt ttccttataa gaattttaag aactaagtgg caaattccat gaaaatattt    660
 ctcagttctg tatgcacttt tatttaacat tattccatat aattctcccc ccacccactt    720
 tatttatagg atactgcaaa agtgaggaag gagataatag atactttgct ctgaatttgg    780
 gcatccagag ttaacatttc tcccctcact cccttgctgg gtgtccatag gttattagga    840
 atcaggcagc ctctttaact aattggcggg tttcatagga tatataaatg tttcaagcca    900
 ttattgctga atggttcttt agttattaac ctagacccaa atcaaagacc agttggattt    960
 atgatatttt ttatttgttc ttgcagccaa agtgccagtt tctttaatat gtgaccaaga   1020
 acacaaggag catccatatg gccaaataaa tacactgaat tttagaaaaa catattactt   1080
 tgaattcaaa ttgtcatgaa aaccagaaca gtgtttgtcc atgttgcatg taatgaaaat   1140
 aaatgccctg cctctgagaa aagcatcttt caagtcaaaa gccag                   1185



      <210> 520
      <211> 456
      <212> DNA
      <213> Homo sapiens


      <400> 520
 gtgattccac agattcaaaa agtgtgtgaa gttgtagatg ggttcatcta tgttgcaaat     60
 gctgaagctc ataaaagtcc aggatacaga ggctgaaact ctgactggtt ttttgaatgg    120
 cattgagtgg attcttgaag aagtggaatc taagcgtgca agatgattct cttttcagat    180
 cttgggaact gaaaccattt gaaatttatt actaaggtcg tgatgtgaat atttgctcag    240
 tcagcccacc ttgtcctgcc tttttgcaga taggctttca tttggacagc tataactgct    300
 gtgtttttta tattattttt actctttacc ataaatcaat tacaagaaaa gagtttcagt    360
 cctagtattt agccccaaaa tgaaccttta aacatttttt tggtaatttt tatattttct    420
 gtctttttaa aaatattaaa ttctggaaaa aacaaa                              456



      <210> 521
      <211> 485
      <212> DNA
      <213> Homo sapiens


      <400> 521
 cgaaagcggc caagtaaagc tccgtcctgt atcttccgcc tcccgtgggc tccggccggc     60
 taagccgcgg cggacaacta tgctgaaagc caagatcctc ttcgtggggc cttgcgagag    120
 tggaaaaact gttttgacca actttctgac agaatcttct gacattactg aatacagccc    180
 aacccaagga gtgaggtttg agccctgctg gccggccctg atgaaggatg ctcatggagt    240
 ggcgatcgtc ttcgatgctg acattccaag ccaccggaag gaactggaga tgtgggattc    300
 ctgcttttgc caacagccgt ccttacagga cacacagtgt atgctaattg cacaccacaa    360
 accaagctct ggagatgata aaggaagcct gtctttgtcg ccacccttga acaagctgaa    420
 gctggtgcac tcaaacctgg aagatgaccc tgaggagatc cggatggaat tcataaagta    480
 tttaa                                                                485



      <210> 522
      <211> 792
      <212> DNA
      <213> Homo sapiens


      <400> 522
 atggggtttc gccatgttgg ccaggctggt ctcaaactcc tgacctcaag tgatctgccc     60
 gccttggcct cccaggtcca gtgtaaactc gtggtccctg catctgcaga aaggcacatt    120
 tcccctctgc agcgcggact gattgcgttc tcgctgcgtc cagatccagg gctcgccggc    180
 gacagagcca gtctcggggt cccactgtgc ggataccgga ttggtaatcc gaggcggagc    240
 cctaagcgca cacgccattg cgcccggaca gcggctgtct catgctctgc atacagcaag    300
 tgcttatatc aattcaggcc gaatgtggga cacagtgcat ctaccccaaa agcgatgtgt    360
 cagaccacgg ccgcagggga gggtgcgcac gccgcggacg agggctacac acaaagagta    420
 gtgggagcga ggcgagggac acctcaacgc tacacgggcg gggcagagac taagaaccga    480
 gcctttcgca gctaccccaa aatggagacc tcttggccgc gcggcggagg gagcaccccg    540
 cctgtagcac tggatgcaca agtggagcgc gagtgcgctc tagggtctgg cgcgcagggc    600
 aagcactcgt gcctggctgt gcgggttgtg cttatatttt gcattaacga acattacccc    660
 caaacactca cctaccgatt acctttcgtg cttcctctcc gctcaggggg aaccccaacc    720
 tcctggagag ctctgttctt tcccagttcc agcgactcta actgtaagct ctgtgggggc    780
 acgagctcat ag                                                        792



      <210> 523
      <211> 609
      <212> DNA
      <213> Homo sapiens


      <400> 523
 atgcctcgcc cccagcgcgc gctcccggcg ccggccccgc cccctcaccc aggcggcgcc     60
 gtaaagccgg agaaggggcg gggtctcagc tcctacttca ttctacggcc gagaccggag    120
 gatgttccct gctcaggagg aggccgacag gaccgtgttt gttgggaatt tagaggcccg    180
 agttcgggaa gagattctgt acgagctgtt ccttcagtgc tgcagcttcc ttactatgaa    240
 atgacagctc cacttcctaa tagtgcatcc gtgtcttcct cactgaatca tgttccagat    300
 cttgaggctg gacccagctc atataaatgg actcaccaac aaccaagtga ctctgacctt    360
 tatcagatga cagctccact tcctaatagt gcatccgtgt cttcctcact gaatcatgtt    420
 ccagatcttg aggctggacc cagctcatat aaatggactc accaacaacc aagtgactct    480
 gacctttatc agatgaataa acgaaagaga caaaagcaaa caagtgatag tgatagtagc    540
 acagacaaca acagaggcaa cgaatgtagc caaaagttcc gaaagtctaa gaagaagaaa    600
 agatactag                                                            609



      <210> 524
      <211> 3333
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(3333)
      <223> n = a,t,c or g


      <400> 524
 acatggagat gtgtcaccca gatgcctctt caaggaagga tctgctgccc agctgcagac     60
 cctagagtta gcaggcagcc tccatctgtc agctccttca ggatctgcca aagccactaa    120
 agtggaatca cttcagtcga gaatatatat tcacctgctc gttgtcttga tggcagtgac    180
 agcctgtctg gagcagctgc tgaggggatg ccagctgcag tatggaaggc gtggccagag    240
 ctgcccactc ctcagagaca gcgggcgcca ggaacatgca agagccccgt cccctaccac    300
 gtcagcgagg cgggagaccc atgttcctgg gcacagctgc agccgtccag ccgcagctct    360
 gcacccagcc atccctgcac tcttgggggc ccaggaaacc ccctgcccct gcaggctgaa    420
 agtgcctgct cctgaggttg cagttcacag catgtccgcc tcggcccctg ctgcggaggg    480
 ggagggaacc cccacccagc ccgcgtccga gaaaagaccc cgaaatgccc ggtcccagag    540
 aggagagcga ggaggaagag gacgaggacg gacgaggagg aggaggagga ggaaaaagaa    600
 aagagtctca tcgtggaagg caagagggaa aagaaaaaag tagagaggtt gacaatgcaa    660
 gtctcttcct tacagagaga gccatttaca attgcacaag gaaaggggca gaaactttgt    720
 gaaattgaga ggatacattt ttttctaagt aagaagaaaa ccgatgaact tagaaatcta    780
 cacaaactgc tttacaacag gccaggcact gtgtcctcat taaaagaaga atgtgggtca    840
 gttcagtggc tttccatttg aaaaaggaag tgtccaatat aaaaagaagg aagaaatgtt    900
 gaaaaagttt agaaatgcca tgttaaagag catctgtgag gttcttgatt tggagagatc    960
 aggtgtaaat agtgaactag tgaagaggat cttgaatttc ttaatgcatc caaagcgttc   1020
 tggcaaacca ttgccgaaat ttaaaaagtc ttgtagcaaa ggcagtaaaa aggaccggaa   1080
 cagttctgga atggcaagta aggctaagcg aaccaaatgt cctgaaattc tgtcagatga   1140
 atctagtagt gatgaagatg aaaagaaaaa caaggaagag tcttcagatg atgaagataa   1200
 agaaagtgaa gaggagccat caaaaaagac agtcaaaaga gaggaaacct aaacagaggg   1260
 ctacttctaa aagtaaaaaa tctgtgaaaa gtgccaatgt taagaaagca gatagcagca   1320
 ccaccaagaa gaatcaaaac agttccaaaa aagaaagtga gtctgaggat agttcagatg   1380
 atgaaccttt aattaaaaag ttgaagaaac cccctacaga tgaagagtta aaggaaacaa   1440
 taaagaaatt actggccagt gctaacttgg aagaagtcac aatgaaacag atttgcaaaa   1500
 aggtctatga aaattatcct acttatgatt taacttgaaa gaaaagattt cataaaaaca   1560
 actgtaaaag agctaatttc ttgagataga ggacagagaa gatgactcgt tccctataga   1620
 tttgaagatc tgatttatac cattatacca gcaaagagaa tgtatttcct tttctaaatc   1680
 cttgttaagc aacgttagta gaacttactg ctgacctttt tatcttgagt gttatgtgaa   1740
 tttgagtttg ctgttttaaa ttgcatttct atgccatttt tagtttaaaa tcttgcatgg   1800
 cattaattgt tccttgcttt tatagttgta ttttgtacat tttggatttc tttatataag   1860
 gtcatagatt cttgagctgt tgtggttttt agtgcactta atattagctt gcttaaggca   1920
 tacttttaat caagtagaac aaaaactatt atcaccagga tttatacata cagagattgt   1980
 agtatttagt atatgaaata ttttgaatac acatctctgt cagtgtgaaa attcagcggc   2040
 agtgtgtcca tcatattaaa aatatacaag ctacagttgt ccagatcact gaattggaac   2100
 ttttctcctg catgtgtata tatgtcaaat tgtcagcatg acaaaagtga cagatgttat   2160
 ttttgtattt ttaaaaaaca attggttgta tataaagttt ttttatttct tttgtgcaga   2220
 tcacttttta aactcacata ggtaggtatc tttatagttg tagactatgg aatgtcagtg   2280
 tttagccaaa cagtatgatg gaacacgtga aagtcaattc agtgatggca acactgaagg   2340
 aacagttacc ctgctttgcc tcgaaagtgt catcaatttg taattttaag tattaactcc   2400
 gtaaaagtgt cctgtaggta cgttttatat tatataagga cagaccaaaa atcaacctat   2460
 caaagcttca aaaactttgg ggaaagggtg ggattaagta caagcacatt tgggcttaca   2520
 agtaaatgaa ctgattttta ataaactgct tttgcccata ttaaaatgct ggataattac   2580
 tgggaaaccc taaccaagct tcacgattaa tgactaaagt accagattat aatgccagaa   2640
 tataatgtgc aggcaatcgt gggatgtctc tgaccaaggg gtgtctcaaa aataatatta   2700
 ctttttacat taaaggaaat tttaatgttt tttctgggag ttgggggctc atggcttttc   2760
 agagtttggt taatccagtg ttgattctag atgatcaaac ataatggacc actcctgaat   2820
 gagaccttaa ttttgtcctt tcaaatttac ctgtccttaa atcagtttat taaatctgaa   2880
 ttttaaaaca tgcctgttta tgacacaatg acacattttg ttgcacccaa ttaagtgttg   2940
 aaaaatatcc tttgcatcat agaacagaaa tatataaaaa tatatgttga atgttaacag   3000
 gtattttcac aggtttgttt cttgatagtt actcgaaagg cnaccatcta gggaaaggta   3060
 aatacaagtg aacaaaataa gcaactaaat gagacctaat aattggcctt cgattttaaa   3120
 tatttgttct tataaacctt gtcaataaaa ataaatcata aatcaaaaaa aaaaaaaaaa   3180
 agggggggcc gttttaaaga atccttgggg gggccaaatt ttacccgggc ttgcaaggta   3240
 aaattttttt ccttataggg agccgaatta aaacctactt ggggattttt ggaaaagaac   3300
 ctttttttgg gggggggaaa aaattggaaa aac                                3333



      <210> 525
      <211> 218
      <212> DNA
      <213> Homo sapiens


      <400> 525
 tttcccgctc cgccgcgcac tgttgtcatg gaggaaccaa gatggcggct ctggcctaca     60
 acctgggcaa gcgggagatc aaccacagtt gtatgatgca taaatacaaa atcagtgaag    120
 caaagaactg ccttgtagat aaacatattg catttattgg agattccaga attcgtcaat    180
 tgttttattc ttttgtaaaa ataattaatc cccaattc                            218



      <210> 526
      <211> 218
      <212> DNA
      <213> Homo sapiens


      <400> 526
 tttcccgctc cgccgcgcac tgttgtcatg gaggaaccaa gatggcggct ctggcctaca     60
 acctgggcaa gcgggagatc aaccacagtt gtatgatgca taaatacaaa atcagtgaag    120
 caaagaactg ccttgtagat aaacatattg catttattgg agattccaga attcgtcaat    180
 tgttttattc ttttgtaaaa ataattaatc cccaattc                            218



      <210> 527
      <211> 928
      <212> DNA
      <213> Homo sapiens


      <400> 527
 caagaacgtc ccagtgccct tggctccttt cggagtgtga ccccgtgctt gcacgggaca     60
 cgttacccag ctcgggtgag aagggtatct tccgggaacc tcgcctttaa tagcacaacg    120
 agcgcagagt ccactggatc tgcgagaaga aaccgcgcta actagtttgt ccctacggcc    180
 gcctcgtagt cactgccgcg gcgccttgag tctccgggcc gccttgccat ggctgcccgt    240
 ggtgtcatcg ctccagttgg cgagagtttt gtcgctacgc tgaggtacct tgcagcccct    300
 cggccaaacg gccagacgcc gacgtcgacc agcagagact ggtaagaagt ttgatagctg    360
 taggtcaggg tgttgcagct cttgcatttg cagggtcgct acgcattaac ggatctggaa    420
 acctctagaa acaagttatc acagaaactg ccaaaggaag atttcaaact cctagctttt    480
 catcctacta taaagtgagg atttgaccag aaaaatgagt atggcgagaa gctgcgtctt    540
 attttaggtg taagcccagt ctgctggcaa ggctaaggat tagaacaagc tcataggagc    600
 agtcatgatt ttggaatcac cccagataaa gggtggatct cccttacgta gcagccaaaa    660
 taaatgaagc aaaagacttt gctagaaaca acccccccaa cattgatgct taaggaccac    720
 actgaaggaa aaaaaaacga ggggacttca aaaaaaaaaa aaagccctgc aaaatattct    780
 aaaacatggt ccttcttaat tttctatatg ggatttgacc acagtcttat cttccgacca    840
 ttaagctgta taacgaataa aatgttaata gtcttgcttt ttattatctt ttaaagatct    900
 ccttaaattc taaaaaaaaa aaaaaaaa                                       928



      <210> 528
      <211> 826
      <212> DNA
      <213> Homo sapiens


      <400> 528
 cggacgcgtg ggtagaagca catagtgata ggcgagggga aacttaaatc atcatcctgg     60
 ggcagccgtg gtggctccat gcgtgaggct ggtgccatgc agtctcctgg tgttggcatt    120
 gtctccaggc cttctcctca gttctgcaca cagctacaaa acaaaagaac agttgccagc    180
 acttggaaga ggatgtggat ccaaaccaaa tggaggacag atactccctc tatggacaag    240
 atactcatgg aagaagtcaa gttagaagag cagctgaagg aggctgtgga agaagataag    300
 caagcactgg cagatactga gggctcagag cagagcagcc aaaaattggt ggaggaggga    360
 aatatgtata gcattcaggg cttctgcaag gactcgttag aggttgcaga tgttttggag    420
 aaggcaacac agtgtgttcc agaagaagaa attaaagaca ataaccctca cctgaagaac    480
 ctctctctat gggaccatct agttgcagga aaagaaggtc aagactccca gtcattctac    540
 attatgtcta tggaaaaact gtcttccaca aaactggtcc ctgctccccc aaaaattggg    600
 gaccgctgca ctcaacacag agagaaaaac aaaaagctca agtctttacc tctcagccct    660
 cagccaagat gtctcacccc actctctctg atgcaacaag aagcccctgg agaacgtttc    720
 agtcccattt tgtacttctg tcatgtgctc atcacagtct ggtaagtgct ggcatacgat    780
 tcctaaatta gtccattttg cattgctgta aggaaatacc tcaggc                   826



      <210> 529
      <211> 279
      <212> DNA
      <213> Homo sapiens


      <400> 529
 aaagggaagc ttagatttat tgagcgccta ctgtgtgcca ggcagtgtgc aaggcgcttt     60
 acatacatta tcgcattaaa tcctcacaac aaccctgcga ggtaggtgtt tataaacccc    120
 catttgacag atgaggaaac tgaggctcag ggaggtgaag tgatgtggcc aagttcacat    180
 ggctaataaa tggcagacag aggaggtgag ccctccttct gctttgttgg ttgttgctgg    240
 acctatgcct cttctcccaa gaacccctct gtcatctga                           279



      <210> 530
      <211> 927
      <212> DNA
      <213> Homo sapiens


      <400> 530
 atgttgcagc aggatagtaa tgatgacact aaagatgttt cactgtttga tgcggaagag     60
 gagacgacta atagaccaag aaaagtcaaa atcagacatc cagtagcatc gtttttccac    120
 ttattctttc gagtcagtgc aatcatcgtc tgtcttctct gtgaattgct cagcagcagc    180
 tttattacct gtatggtaac aattatcttg ttgtcatgtg acttttgggc agtgaagaat    240
 atcacaggta gactaatggt tggcctacgt tggtggaatc acgttgatga agatggaaag    300
 agccactggg tgtttgaatc tagaaaggag tcctctcaag agaatgaaac tgtgtcagag    360
 gctgaatcag gaatcttttg gttgggactt gttgcctgtc cagtgctgtg ggtgatactt    420
 gccttcagtg cacgcttctc cttcagagta aaaagtggtt ggcggtggtt atcgtgggtg    480
 tggtgctaca aggtgccaac ctgtatggtt acctcaggtg taaggtacct agtgtcagaa    540
 ttgaatcatt ggacacccag ttgggcatcc agaattggag aattggttgg tatgagggaa    600
 aagcccacac atctggtgtc agaagtgttg gaaatagaaa cagatcagaa tgacacgcat    660
 ccgtgtttgc tccagctgag gctgcaacaa aggaggacga gagaacaact agtggaccag    720
 ggcatcatgc cacaaacatt tgcagagcca tccctgcagg ctactcagat gaagttgaaa    780
 agagctcgac tagcagatga tctgaatgaa aagattgctc aaagacctgg tcctatggag    840
 ctggtagaga aaaacatcct tcctgtggac tccagtgtta aagaagcaat tataggcaag    900
 actctaaaaa tttactattt ggggtga                                        927



      <210> 531
      <211> 2333
      <212> DNA
      <213> Homo sapiens


      <400> 531
 gaacttgcta atctcttttg tcacattcgg attgctcctg ctgccccaca cacactaacc     60
 caaccatgtt ggggtggact ccctgccagc ccaactgttg tattttcagt tcttccagtg    120
 tgaatcagtt aatattctcg ggaacgaggc gagaggttga tcctatgagg aaatcaacca    180
 cagtgaaaag gcttgggccg cttttgtttt cacctgcttt tgttgaacaa atttgatttc    240
 ccggagtcag tcattttact gtcaagacat ttcttcggca ttctgcaaca gtttccaaca    300
 tggccagatc catcagaaac tgaagccgtg gagaacgctc tcggggcctt tgccacttct    360
 tggagtagaa gccgacagag agctgttttg gaaacttctc cttcacacac cagttgaaga    420
 ctaggctttg gaggttttca aagcagacgg tgcttgggat gggcagggag aagtaacatt    480
 ctgcaaatcg ccgtcagagg tcctgaggac acagacctac ctggcttgca ttccccttgc    540
 tgaatggcgt gtgctgcagc tgcccactga gggctctttt ccctgggatt ctggacttca    600
 gagtaggaca gcaggctggg aagatgctga gttccatcaa gtgcgtgttg ggtgggcgac    660
 tctgcggtgg ggaaaacttt tctggtgggt gcgtttcacc tccagaaccc tccgggaagg    720
 ctacagcccc ccagtgtacg agaacacagg ggtggacgtc ttcatggatc ggcatccaga    780
 tcagcctggg ccctctggga cacagcggca aatgacgctt tcagaagcat ccggcccctg    840
 tcctaccagc aggcagacgt ggtgctgatg tgctactctg tggccaacca taactcattc    900
 ctgaacttga agtaacaagt ggattggtga aattaggagc aacttgccct gtacccctgt    960
 gctggtggtg gccaccccag actgaccagc ggggagatgg gcccccacaa ggcctcctgc   1020
 gtcaatgccc tggaagggga agaaactggc ccaggatgtc agaggcaagg ggctacctgg   1080
 agtgctcagc ccttagccaa tcggggagta cagcaggtgt ttgagtgcgc cgtcccgaaa   1140
 ctgccgtcaa ccaggccagg agacgaaaca gaaggaggct ctttctccat caaatgagtg   1200
 caagatcttc taaaccccaa gagactttca cacaacactt atgtatgcac cccaaagact   1260
 aatggggaga gggagggccg ggaagccagg aaagcttggt gttttctctg ggtacacccc   1320
 aagcgagcgt ctccgttttg gatacagtta ttgatgaggc ttggccactg gatgttttca   1380
 ctaactacac tctacaagtg aactccttgc ccaggcccag ttagaaaatc ccttggggaa   1440
 ctgtgatgaa tattccatct ttgattaaaa aagtgaaata gtctccataa ttttggccga   1500
 tgaagtgagt ttttcaaaga attcccatat ttagagacac caattttatt taactaataa   1560
 caaaatgtat tgcttttgta tatatttagt tttcacactt tgggaaatct tttcctacat   1620
 ccctcgaaaa cataaaactc ctctgtgagt gaaatgcttg tacgaaggct ctgccatatg   1680
 tttgtagtgt tattattttc acctcaagta gaaaggtctg ttgaaaccac ttgggctgct   1740
 ggatttaaat gggtaatcaa atttaaaaat gaccataaat gaatctttgc aatttgtttt   1800
 ctacttacct gttattcaca gttggatata aaatacagtt ccataagata tcctaatact   1860
 gcctaatgat tttaaagtta tcactatatt tttctgaaat gataaaacat cattcattta   1920
 tttactatat tgtctttcac tcaactccag ttatgcacta aatattctcc tctcattcac   1980
 caagattgat tgaaacacca tctttcaggt agagaatcag actgctccaa gcaatggcaa   2040
 cagaacttgg aacagaagcg agagagtgtc actttcactt ctggtagggt ggttcccagg   2100
 cgactgcagg tcttgtgaaa gacaggggtc tcaaagttct gttaatttca caaatttgtt   2160
 ataaatttgt ctaaactgag ctgttgtggc aacataattt atgaatcgta aggtctagtt   2220
 aggcttattg gggggatatc tacatatata tgtgtatgta agggaaaaaa ggtagaattt   2280
 acagccttca aaaaagaaaa atcaaattcc aagcacagga ataagaaagc tat          2333



      <210> 532
      <211> 891
      <212> DNA
      <213> Homo sapiens


      <400> 532
 ctaactgggc tcgtcggcct gccccagctg caggcccggt gctacacggg ctcgggaaca     60
 gaacatcgtg ggcatgcgca gagcatgccc atccgtggca ggtacgccac agcagacaca    120
 aaggtatggg agcttggtgc ctccagccac aaaagtggaa ggccgtgggc ccagagtccc    180
 ctgtggcagg tccagggccc aggctgtgcc ctcaggctgt ggcaggcagc ccccagccat    240
 aagccggccc agccagtggc tctcacactg gccagtgggt ggcgggtggc tctccaggta    300
 gaggcccagg ccccggaggt ggcgcagccg gaagttcttg ggcttgcttc cctgggcact    360
 ggggcactgc ggctgcgggg accccaggcc cccctcgtag atgttggggg gtgcgtcagg    420
 gtggccgggg cgtccttggg cctggctcac tgcatcgtcc agacgaacta actccacatt    480
 caaccaggtt gtgctgaaga ggttgtttat gagtcgcacc aaccggccac ctctgtccgt    540
 ttcccggatg atccggaaga tgaagcttcc gtgcgccgtc caagggtcca ttggttgcca    600
 tagagatcgt cgagcgctgg gcctgtgatc gctgaggggc gagcagttgc gaccctgggc    660
 tcctggggac ctgagcgtta tgtctttccg cgacctccgc agtaaggcag ccccgcgccc    720
 ctgtgacctg cgggtcttcc agagattcag ggctcccgcc cgccgggtcc cctgtgtagg    780
 cgatccctga ggcttgcgct gccggaggct cctttcgggc ctctgcgcct cagggaccgc    840
 ctgacccgcg gctgcaaccc ggccgagcgt cccaggccct tcttcggcca t             891



      <210> 533
      <211> 1406
      <212> DNA
      <213> Homo sapiens


      <400> 533
 atggaggcag ctcagtcatc ttctacggcc tcatctgcat gtatacactg tggtggatgc     60
 tacgggcgct ccctcaaaaa gtactcgttt gagtcgatcc gtgaggagag cagctacagc    120
 gacatccccg acgtcaagaa cgacttcgcc ttcatgctgc acctcattga ccaatacgac    180
 ccgctctact ccaagcgctt cgccgtcttc ctgtcggagg tgagtgagaa caagctgcgg    240
 cagctgaacc tcaacaacga gtggacgctg gacaagctcc ggcagcggct caccaagaac    300
 gcgcaggaca agctggagct gcacctgttc atgctcagtg gcatccctga cactgtgttt    360
 gacctggtgg agctggaggt cctcaagctg gagctgatcc ccgacgtgac catcccgccc    420
 agcattgccc agctcacggg cctcaaggag ctgtggctct accacacagc ggccaagatt    480
 gaagcgcccg cgctggcctt cctgcgcgag aacctgcggg cgctgcacat caagttcacc    540
 gacatcaagg agatcccgct gtggatctat agcctgaaga cactggagga gctgcacctg    600
 acgggcaacc tgagcgcgga gaacaaccgc tacatcgtca tcgacgggct gcgggagctc    660
 aaacgcctca aggtgctgcg gctcaagagc aacctaagca agctgccaca ggtggtcaca    720
 gatgtgggcg tgcacctgca gaagctgtcc atcaacaatg agggcaccaa gctcatcctg    780
 tggtacaacc acatcgccta catccccatc cagatcggca acctcaccaa cctggagcgc    840
 ctctacctga accgcaacaa gatcgagaag atccccaccc agctcttcta ctgccgcaag    900
 ctgcgctacc tggacctcag ccacaacaac ctgaccttcc tccctgccga catcggcctc    960
 ctgcagaacc tccagaacct agccatcacg gccaaccgga tcgagacgct ccctccggag   1020
 ctcttccagt gccggaagct gcgggccctg cacctgggca acaacgtgct gcagtcactg   1080
 ccctccaggg tgggcgagct gaccaacctg acgcagatcg agctgcgggg caaccggctg   1140
 gagtgcctgc ctgtggagct gggcgagtgc ccactgctca agcgcagcgg cttggtggtg   1200
 gaggaggacc tgttcaacac actgccaccc gaggtgaagg agcggctgtg gagggctgac   1260
 aaggagcagg cctgagcgag gccggcccag cacagcaagc agcaggaccg ctgcccagtc   1320
 ctcaggcccg gaggggcagg cctagcttct cccagaactc ccggacagcc aggacagccc   1380
 tcttggctgg gcaggagcct ggggca                                        1406



      <210> 534
      <211> 3300
      <212> DNA
      <213> Homo sapiens


      <400> 534
 agtcctctcg gcctctgtgc gctcagttgt ttacctaggc gtccggggga ggcacactcg     60
 cgggactcgc gggactcggc cccggcctcc cagctcgccc aggacacgac gctggttctg    120
 cgggctctcg gagcccagcg cgaatccccc gggctaattc ccaagaaccg agaggcagca    180
 ctgcctggag gctgcccccg cctccgcgcc cccgtcctca ctttctgagg ctgttagcag    240
 agagtcccgc gggccgggga gaagcgggac gcgggggatg gcctcgcagc gccctgtgag    300
 cgtcggcagt agtcaggcag ccagggctcc ttgggcgatc gccctgggta gaggagagga    360
 gtttccgggg ctcgggtccg ggtcgccttc caggggaacg agcgcggaag caagtgggcg    420
 gcgagaggcg gagcaagaga cgctggaggg cgtggacgca gcgggctttg gaaaggcccc    480
 aagttaatga ggcgtgcgcc ggctgccgag cgcctcttgg agctgggctt tcccccgcgg    540
 tgcgggcgcc aggagccgcc ttttccgctg ggtgtcactc gggggtgggg aagatggccc    600
 attcaaaagc gccgcgaggg ggcccggcca gtgcccttca gtgagcgctc gcaagaggac    660
 ggcagaggcc cggcagctcg gagctccggg accttgtggc gcatcaggac gcggctgtcc    720
 ctctgccggg acccagagcc gccgccgccg ctctgcctcc tgcgtgttag cctcctctgc    780
 gcgctccggg caggcggccg tgggagccgc tggggcgagg acggcgcgag gctgctgctg    840
 ctgcccccgg cccgcgcggc tggaaacgga gaggccgagc caagcggcgg cccctcttat    900
 gctgggagga tgctggagag tagcggctgc aaagcgctga aggagggcgt gctggagaag    960
 cgcagcgacg ggttgttgca gctctggaag aaaaagtgtt gcatcctcac cgaggaaggg   1020
 ctgctgctta tcccgcccaa gcagcatgca acaccagcag cagcagcaac agcagcagca   1080
 gcagcagcaa caacagcccg ggcaggggcc ggcccgagcc gtcccaaccc agtggccccg   1140
 cttgtcgcca gcctcgagcc gccggtcaag ctcaaggtaa ctgctcttct ccaacatgaa   1200
 gaccgtggac tgtgtggagc gcaagggcaa gtacattgta cttcactgtg gtgatggcag   1260
 agggcaagga gatcgacttt cggtgcccgc aagaccaggg ctggaacgcc gagatcacgc   1320
 tgcagatggt gcagtacaag aatcgtcagg ccatcctggc ggtcaaatcc acgcggcaga   1380
 agcagcagca cctggtccag cagcagcccc cctcgcagcc gcagccgcag ccgcagctcc   1440
 agccccaacc ccagcctcag cctcagccgc aaccccagcc ccaatcacaa ccccagcctc   1500
 agccccaacc caagcctcag ccccagcagc tccacccgta tccgcatcca catccacatc   1560
 cacactctca tcctcactcg cacccacacc ctcacccgca cccgcatccg caccaaatac   1620
 cgcacccaca cccacagccg cactcgcagc cgcacgggca ccggcttctc cgcagcaccc   1680
 tccaactctg cctgaaaggg gcagctcccg ggcaagacaa ggttttgagg acttgaggaa   1740
 gtgggacgag cacatttcta ttgtcttcac ttggatcaaa agcaaaacag tctctccgcc   1800
 ccgcaccaga tcaagtagtt tggacatcac cctactgaac aacttggcga ttcttcttag   1860
 ttttctgcat acttttcatc acgatgcagg aaacgatttc gagtcaagaa gacttttatt   1920
 tatgaacctt tgaaaggatc gtcttgtatg gtgaattttc taggagcgat gatgtactgt   1980
 aattttattt taatgtattt tgatttatga ttatttatta gttttttttt aaatgcttgg   2040
 ttctaagaca tttctgaatg tagaccattt tccaaaaagg aaactttatt ttcgaaaaac   2100
 ctaatccgta gtaattccta atcttggaga ataaaaaagg gcggtggagg ggaaaacatt   2160
 aagaatttat tcattatttc tcgagtactt tcagaaagtc tgacactttc attgttgtgc   2220
 cagctggttg aaattaaaac tcctgatatt actttttttg aggattttta tttttgtttt   2280
 tgcttaaaca tatagtttgt ctagaagttt aaaaagctaa aagttaaaaa tggtgtaatt   2340
 atgaaaatct aacactcaag atagtttcta aaaggaaatc agtagttaag gatacctgat   2400
 ttcaaaatat ttaaagcata accctaactg atggtaggat gattgtatcc tgaatatgtg   2460
 gtagggccac atctattgta ggaaaacctt gcttttatca tctgtgtgta aagggcttaa   2520
 taaggagaag aggccttttg actgatttgt gagtataaat gcatttgctg tttcatttca   2580
 aaaatgttgt ggaggaaaag ggtacattta acttgtataa gagaatattt gtactcctgt   2640
 ccaggctgca ggacctttct tcgagagctt tgcacacttg acttgaacca cattttctga   2700
 tccctttact ttgttttaga agcacactga aaaatctccg ttgtttaaag tacaatttgt   2760
 aaatatttca aaggtctagg agtcataact tttgttttca tactgaaaat gatgttgatc   2820
 agagaaacca actgttttgc ttttcattgc tctgtgagaa atttgaggat tctgttttgc   2880
 tgttaggtaa gctaaactca gaaattgaaa aggaaaagac tggataaaca caggattttc   2940
 agtaagaaaa caaccccagt cttgtcttag aagccacttg ttgaggagtc tgttggggga   3000
 aaaaagagga tatgctttta aagggtagaa caaaccttcc tctgtgttaa atcaaaagga   3060
 tggttcaaat ccaccaggac agatgctact tgggtttaaa tggagccata gatgatacaa   3120
 agtcctcttg gggctgaaaa tcacttccta tttgcatggc tttactaact ggtttctgtt   3180
 ttccattatc tttttcacag aaagtcttgg tcagtatttt tccagcattt aaattgaaac   3240
 ggtcagtatt agaccactgc taggttatgt agtcaagaaa taaaaataga attacatgct   3300



      <210> 535
      <211> 422
      <212> DNA
      <213> Homo sapiens


      <400> 535
 caagatgacg gagccgggcg cctctcccga ggacctttgg gtcaaggtgg agtatgccta     60
 cagcgacaac agcctggacc ccgaccctgc gggagattgt gattggcgtc ctgcaccaat    120
 tgaaaaacca gctttactga ccggttcttg gaaacctgga gaacagccaa caagaggccc    180
 ttgaatctct acgtggccac tgaactgctg ggcccgggag actggactac aacacctcac    240
 actggtcagc tggtttctac ttggtgtttg gtttttccca gccccatttt atcttcagcg    300
 gagccgcggt gtttgttttg tgaaagcttc tgattaattt attatattga cgataaaact    360
 caaacctacc cagccttccc cccactccat ggaagtcctt gggatgggcg tctgctctgg    420
 ac                                                                   422



      <210> 536
      <211> 422
      <212> DNA
      <213> Homo sapiens


      <400> 536
 caagatgacg gagccgggcg cctctcccga ggacctttgg gtcaaggtgg agtatgccta     60
 cagcgacaac agcctggacc ccgaccctgc gggagattgt gattggcgtc ctgcaccaat    120
 tgaaaaacca gctttactga ccggttcttg gaaacctgga gaacagccaa caagaggccc    180
 ttgaatctct acgtggccac tgaactgctg ggcccgggag actggactac aacacctcac    240
 actggtcagc tggtttctac ttggtgtttg gtttttccca gccccatttt atcttcagcg    300
 gagccgcggt gtttgttttg tgaaagcttc tgattaattt attatattga cgataaaact    360
 caaacctacc cagccttccc cccactccat ggaagtcctt gggatgggcg tctgctctgg    420
 ac                                                                   422



      <210> 537
      <211> 422
      <212> DNA
      <213> Homo sapiens


      <400> 537
 caagatgacg gagccgggcg cctctcccga ggacctttgg gtcaaggtgg agtatgccta     60
 cagcgacaac agcctggacc ccgaccctgc gggagattgt gattggcgtc ctgcaccaat    120
 tgaaaaacca gctttactga ccggttcttg gaaacctgga gaacagccaa caagaggccc    180
 ttgaatctct acgtggccac tgaactgctg ggcccgggag actggactac aacacctcac    240
 actggtcagc tggtttctac ttggtgtttg gtttttccca gccccatttt atcttcagcg    300
 gagccgcggt gtttgttttg tgaaagcttc tgattaattt attatattga cgataaaact    360
 caaacctacc cagccttccc cccactccat ggaagtcctt gggatgggcg tctgctctgg    420
 ac                                                                   422



      <210> 538
      <211> 422
      <212> DNA
      <213> Homo sapiens


      <400> 538
 caagatgacg gagccgggcg cctctcccga ggacctttgg gtcaaggtgg agtatgccta     60
 cagcgacaac agcctggacc ccgaccctgc gggagattgt gattggcgtc ctgcaccaat    120
 tgaaaaacca gctttactga ccggttcttg gaaacctgga gaacagccaa caagaggccc    180
 ttgaatctct acgtggccac tgaactgctg ggcccgggag actggactac aacacctcac    240
 actggtcagc tggtttctac ttggtgtttg gtttttccca gccccatttt atcttcagcg    300
 gagccgcggt gtttgttttg tgaaagcttc tgattaattt attatattga cgataaaact    360
 caaacctacc cagccttccc cccactccat ggaagtcctt gggatgggcg tctgctctgg    420
 ac                                                                   422



      <210> 539
      <211> 1734
      <212> DNA
      <213> Homo sapiens


      <400> 539
 ccgcgcgtcg tgcccgacca gagaagcaag ttcgagaacg aggagttttt taggaagctg     60
 agccgcgagt gtgagattaa gtacacgggc ttcagggacc ggccccacga ggaacgccag    120
 gcacgcttcc agaacgcctg ccgcgacggc cgctcggaaa tcgcttttgt ggccacagga    180
 accaatctgt ctctccaatt ttttccggcc agctggcagg gagaacagcg acaaacacct    240
 agccgagagt atgtcgactt agaaagagaa gcaggcaagg tatatttgaa ggctcccatg    300
 attctgaatg gagtctgtgt tatctggaaa ggctggattg atctccaaag actggatggt    360
 atgggctgtc tggagtttga tgaggagcga gcccagcagg aggatgcatt agcacaacag    420
 gcctttgaag aggctcggag aaggacacgc gaatttgaag atagagacag gtctcatcgg    480
 gaggaaatgg aggtccatga gctggagaag tccaagcggg ccctggagac ccagatggag    540
 gagatgaaga cgcagctgga agagctggag gacgagctgc aagcctcgga ggacgccaaa    600
 ctgcggctgg aagtcaacat gcaggcgctc aagggccagt tcgaaaggga tctccaagcc    660
 cgggacgagc agaatgagga gaagaggagg caactgcaga gacagcttca cgagtatgag    720
 acggaactgg aagacgagcg aaacgaacgt gccctggcag ctgcagcaaa gaagaagctg    780
 gaaggggacc tgaaagacct ggagcttcag gccgactctg ccatcaaggg gagggaggaa    840
 gccatcaagc agctacgcaa actgcaggct cagatgaagg actttcaaag agagctggaa    900
 gatgcccgtg cctccagaga tgagatcttt gccacagcca aagagaatga gaagaaagcc    960
 aagagcttgg aagcagacct catgcagcta caagaggacc tcgccgccgc tgagagggct   1020
 cgcaaacaag cggacctcga gaaggaggaa ctggcagagg agctggccag tagcctgtcg   1080
 ggaaggaacg cactccagga cgagaagcgc cgcctggagg cccggatcgc ccagctggag   1140
 gaggagctgg aggaggagca gggcaacatg gaggccatga gcgaccgggt ccgcaaagcc   1200
 acacagcagg ccgagcagct cagcaacgag ctggccacag agcgcagcac ggcccagaag   1260
 aatgagagtg cccggcagca gctcgagcgg cagaacaagg agctccggag caagctccac   1320
 gagatggagg gggccgtcaa gtccaagttc aagtccacca tcgcggcgct ggaggccaag   1380
 attgcacagc tggaggagca ggtcgagcag gaggccagag agaaacaggc agccaccaag   1440
 tcgctgaagc agaaagacaa gaagctgaag gaaatcttgc tgcaggtgga ggacgagcgc   1500
 aagatggccg agcagtacaa ggagcaggca gagaaaggca atgccagggt caagcagctc   1560
 aagaggcagc tggaggaggc agaggaggag tcccagcgca tcaacgccaa ccgcaggaag   1620
 ctgcagcggg agctggatga ggccacggag agcaacgagg ccatgggccg tgaggtgaac   1680
 gcactcaaga gcaagctcag agggcccccc ccacaggaaa cttcgcagtg atgc         1734



      <210> 540
      <211> 422
      <212> DNA
      <213> Homo sapiens


      <400> 540
 aatgaagaaa aacttaactt tattgagcat aggaatagac gggctttcaa attatttttt     60
 gctttatggt tattactttt ataaaccatc tgatccacgg caaaactaca ttgcttaagg    120
 tggtaataag gggtcagatg ctctacagca accttcaagc acaggcaccg atttgcattt    180
 tatgcaaaac ttcaggtttt actcaatttt tacactggtg gaagctgatg tcagtaactt    240
 aaaaggcaag caaatacttt tccaattctt agctgaacaa aaaatacaca caatgtagcg    300
 tttttattgg gcaagacttg ctttttatat ttcacgtgag aatgcaatat aacccttcct    360
 tgaacaaaat gaccagggta ctaataaaac catctttgca ggagtgttta ataagcatat    420
 tt                                                                   422



      <210> 541
      <211> 571
      <212> DNA
      <213> Homo sapiens


      <400> 541
 gcggtggaat tccccgtgta ttcctgtacg agctgctccc cgagtcccct ttcttcctgg     60
 agtgcaacag cttcacgtcg cctgaccccc acaagggcct cgtcctcctg cctaagacgg    120
 agtgcgacgt gcgggaagtg gagctgatgc ggtgcctgcg gctgcgtcag tcctccctgg    180
 agcctgtggc cttccggctg ccccgagtcc ggaaagagtt cttccaggat gacgtgttcc    240
 cagacacggc tgtgatctgg gagcctgtgc tcagtgccga ggcctggctg caaggcgcta    300
 atgggcagcc ctggcttctc agcctgcagc ctcctgacat gagcccaggt gcaccgaggg    360
 actgggtgtg gggaggaagc gggatggggg ttggagaaag ggacagaagg cccaggttga    420
 agttccattc ctgttggcac gcagaatcct ctggcctttg ggagggtgga gtggctgtgt    480
 caatcagtct ctgagccagt ggagggcagg gctcgtggtc tgtgttttca tcacaggtcc    540
 cccccccccc caaaaaaaaa aaaaaaaaaa a                                   571



      <210> 542
      <211> 822
      <212> DNA
      <213> Homo sapiens


      <400> 542
 atggttcctg atgaaaggta catcactcag gaaggccaca agctggaaac aggggccccg     60
 cggccaccag ccaccgtcac caacgcggtg tcctggcggt ccgaaggcat caagtatcgg    120
 aagaatgagg tgttcttgga cgtcatcgag tctgtcaacc tcttgcagct tgaggttacg    180
 ttctttgctg gagaaaagcg ttttgaaaca gaaacgccca cggtgtccct gacgctgagt    240
 tgtggaaacc ccaggctcat cgtcgctaga gcaaccccac ctcccttcct ggagcagctc    300
 agccaatcaa agagaagcga ggcggccatt cgggcggaaa tagtgtttgc aaacaggaag    360
 tgtggcactc cagctaccga agcactggag agtgtcatgg aggcctacga gcaggtccaa    420
 aagggacccc tgaagcttga aaggcttcgc agagctggga gtgaccaagc ggaaggaaga    480
 aaaaggaagg acaaagacaa agcgaaactc ctggaagcaa tgggaacgga gcaaaaagaa    540
 cggaggagga gaagcggcgc ggcctggaca agcggacccc ggcccaggcg gccttcgaga    600
 aaatgcagga gaagcgggtg ctcatctgcc ggaactaccg tggcgacgtg gacatgtcag    660
 aggtggagca cttcatgccc atcctgatgg agaaggagga ggaggggatg ctgtcgccca    720
 tcctggccca cgggggggtc cgtttcatgt ggatcaaaca caacaacctg tatcgtatcc    780
 ctttgctggg ggtgctccca ggggactcct gtgtgggtgt tg                       822



      <210> 543
      <211> 1430
      <212> DNA
      <213> Homo sapiens


      <400> 543
 gacgccagcg cctgcagagg ctgagcaggg aaaaagccag tgccccagcg gaagcacagc     60
 tcagagctgg tctgccatgg acatcctggt cccactcctg cagctgctgg tgctgcttct    120
 taccctgccc ctgcacctca tggctctgct gggctgctgg cagcccctgt gcaaaagcta    180
 cttcccctac ctgatggccg tgctgactcc caagagcaac cgcaagatgg agagcaagaa    240
 acgggagctc ttcagccaga taaaggggct tacaggagcc tccggggaaa gtggccctac    300
 tggagctggg ctgcggaacc ggaggcaact ttcagttcta cccaccgggc tgcagggtca    360
 cctgcctaga cccaaatccc cactttgaga agttcctgac aaagagcatg gctgagaaca    420
 ggcacctcca atatgagcgg tttgtggtgg ctcctggaga ggacatgaga cagctggctg    480
 atggctccat ggatgtggtg gtctgcactc tggtgctgtg ctctgtgcag agcccaagga    540
 aggtcctgca ggaggtccgg agagtactga gaccgggagg tgtgctcttt ttctgggagc    600
 atgtggcaga accatatgga agctgggcct tcatgtggca gcaagttttc gagcccacct    660
 ggaaacacat tggggaaggc tgctgcctca cccaaaagac ctggaaagat cttgagaaac    720
 gcccagttct ccgaaaacca aagggaacga caggcccctt ccctgaaggg gcctaccctg    780
 tgggcccccc catcattgga aaggggctgc aaaaaattct ttcccaggga tggagagcaa    840
 gaaacgggag ctcttcagcc agataaaggg gcttacagga gcctccggga aagtggccct    900
 actggagctg ggctgcggaa ccggagccaa ctttcagttc tacccaccgg gctgcagggt    960
 cacctgccta gacccaaatc cccactttga gaagttcctg acaaagagca tggctgagaa   1020
 caggcacctc caatatgagc ggtttgtggt ggctcctgga gaggacatga gacagctggc   1080
 tgatggctcc atggatgtgg tggtctgcac tctggtgctg tgctctgtgc agagcccaag   1140
 gaaggtcctg caggaggtcc ggagagtact gagaccggta ggtgtgctct ttttctggga   1200
 gcatgtggca gaaccatatg gaagctgggc cttcatgtgg cagcaagttt tcgagcccac   1260
 ctggaaacac attggggaag gctgctgcct cacccaaaag acctggaaag atcttgagaa   1320
 acgcccagtt ctccgaaaac caaagggaac gacaggcccc ttccctgaag gggcctaccc   1380
 tgtgggcccc cccatcattg gaaaggggct gcaaaaaatt ctttcccagg              1430



      <210> 544
      <211> 204
      <212> DNA
      <213> Homo sapiens


      <400> 544
 gcagctgcca gacccggcca tcgaggacca gggtggggag tacgtgcagc ccatgctgag     60
 caagtacgcg gctgtgtgcg tgcgctgccc tggctacggc accagagggc cggcaaagaa    120
 gccaagtgcc catagccaga gccaggcttc ttcctcgcct gagtggattc cagagcttct    180
 gccctgtcca gacgcagctg cagg                                           204



      <210> 545
      <211> 386
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(386)
      <223> n = a,t,c or g


      <400> 545
 gcagaatcag actatcagga aaggagctgg ccatggccat agccagtcaa gatctctgag     60
 caacttaaag acattggtgt cattatatga agcttgcatt taatacattt atacataata    120
 catttgtaca tttaattcat aacgtctctt ggtcacagat gccttatata taaaataagt    180
 tgccagatct ctaagattgc ctagaacacc tttgtatctc atttgatgtg atacccagaa    240
 gagatcattg gnnnnnnnnn nnnnnnnnnn nnnnnncaag aagatccttc gtgatcacca    300
 tgctgttctc atggtaagaa ctggagttat gtttttaaat ttggaaatat gacattttat    360
 gtagcacttt ataaaaagtg aaagcg                                         386



      <210> 546
      <211> 1827
      <212> DNA
      <213> Homo sapiens


      <400> 546
 ttagtccaca ggtcgctttt ccccatattt ctttgtaaac tcttcagcat tcttacagaa     60
 ttttttacgg tccttagagt attcttcagc taggtcagcc cgaagcgggt gctcaggctg    120
 ggggtcattc accagtgcta tgagggactg gattacaggg tggagcgccg tgtcctccac    180
 cgacgtcaat gacgtgctga ggttcaccca ttcattcacc tgcgaatgct gcaccgactg    240
 gggaccgggc tcctcactgt tcttggaaaa gttcagcttg atcagggacc tcccgtccag    300
 cttctctcca ttgctggggt tggtcccgta cttcttaagc catggaacaa tgttcagtaa    360
 gtcaaagacg atgccatcgg gagtgcagac tggcttcttg ccaccataaa agtgagtgta    420
 ttcagcacag gtaatgtaca ttttgtcctt ttggtgctgt cgcttcccca tggcggagcg    480
 gcggcggcga aattgagacc tgttgctgtt gggcccggag ttggccatgc tgaggatgcc    540
 gcggcccgtg tgcgagaggt tgggccggaa ctcgtctttg aagggcttcc cccagtatga    600
 ctccccaccc gtgcctgtgc ctgtggggtc gcccccttgg atcacaaagt tccggatgga    660
 tctgtggaag atggtgccat cgtaataatg cttcttgcaa agcctgatga agttttcgca    720
 ggtttttggt gtctgtgcgc aggccatgct gccaacgcgg ccccctagga aggacacagg    780
 gcactgctgc gggtcccgcc tagtgacagg ctgaatttcc agtggcagcc ctatatttaa    840
 gacatggctg tcagatgacc cagagatgac cttggggcat ggggagtggc tggcctccac    900
 acccaccagg tcgcagtgca gctccaggtt gaggtcgccc ttgttggtgt gcagccgcac    960
 gtagcccttc ttcttcacaa actggtagcg cagcacatcc tcgtcgatgg cagctgcttc   1020
 atgtgtggtc tccgggacca tcgcggtgga ggtgaaggaa gcgctgacct tccctgtgga   1080
 atagtgggca gcattcagct tgtccacttt cttcttctcc ggggccttca tggtggctgc   1140
 cagaatctcg tcccctttga actccttgta gagctcctgc agggtctctc gggtctcggc   1200
 atttgtattt ttcagataat aagacgggtc ctgtttggcc ttctcttcat ctgggtctat   1260
 tattttcatg ttattcttca catgatagaa gttagagaca ttgaacttgt ccaaattggt   1320
 ggggtcctgg agggtgatga tgtcctgccg ggagaagggc tcgtcggtca gcaggtcccg   1380
 gaagttcttg gccttgatat ttagctgttc cactgcctca taggcgtaga cgttgccggt   1440
 cgtcctcaca gccacgatgt gggtgttgtt ggtgaacacg gtaaacagca ctgggcagtg   1500
 gtacttccct gcttcacacg catgttctct ctgtaaccca ccactttgtc tgattggttg   1560
 gcaggttacg tttttctctc gtcccagctg tgtggacagt gccacacgcc ctcctggaca   1620
 acgacggctc ttgcgtgcat tttccagtgt tgcttttgtc agagaggcca gcagagccac   1680
 ggttcttcca gaaccagccc tgagctgagt gaggagtgcc caggagagat ggtgaaaatg   1740
 acaaagtcca aaactttcca agcgtatctg ccgaactgtc accgaacgta cagctgtatc   1800
 cactgcagag cacacctggc caatcat                                       1827



      <210> 547
      <211> 665
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(665)
      <223> n = a,t,c or g


      <400> 547
 gttgtaacac tccaatacaa cagctggaca gaatgatgga attcacgtca atagaaggcg     60
 gtgcaaaaca ctcagcaact caacacctat tcagctgatc ttctgcaata tggactcgag    120
 cataagggga agtctagcaa ggttatgtaa gggcctgcag gcatgctgtt acatgttcaa    180
 ttgggctcct caggtctagg tgtactttga tactgtatac tcacaccttg atatcagatg    240
 cattctgtct ttgttaattt ctggcataag atttagcact acccactgct cctgatgcct    300
 ggtttaaatt gacagatgta gaacgttttt gtaaaccaga tattgctgct gcttctgtag    360
 actctgagca cgtaaatcct gtgctattta accaaagtgc caccgcatgg agaattgggg    420
 cccaggaatt ccgatagtta agtcttagct gtatcaatag tttcaggggt ataaaatggc    480
 tccaccatct ggaggaagct gactagaaaa ttcggctggt aaagtcaaga gtgcataatc    540
 ttttaatgct gctaaccaca ggcgactgag tgttggtagt tcaggttgta ccagtgttat    600
 taaactatct ggtgacagtt catcgatgcg nacgcgtgga cgcacgcgtg ggcgtacgcg    660
 tgggt                                                                665



      <210> 548
      <211> 1169
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1169)
      <223> n = a,t,c or g


      <400> 548
 gcacgagggg atgcaagtga atttagtaaa aatccccata ttgggagttt tgttggaaat     60
 caagtaacta ttagaaaagc tgatggctcc ctggttcaca tcagcataac accatatcct    120
 gctattctcc atgaatatgt aagcagttca aaatgggaag atgctgtgag actttgtcgc    180
 tttgttaagg agcaaaccat gtgggcttgt ctagctgcta tggcagctgc taatcgagat    240
 atgactactg cagaaatagc ctatgcagca attggcgaaa ttgataaggt tcagtacatc    300
 aattctataa aaaatcttcc atctaaagaa tcaaaaatgg cccacatact actgcttagt    360
 gggaacatac aggaggctga aatagtactt cttcaggctg gcctttgtta tcaagcaatc    420
 cagatcaata ttaatctcat accactggga aagggcactg gaattggctg tccaacacaa    480
 aacacatgtt gatacagttc ttgcttaccg gcaaaagttt ttggagacat ttggtttgca    540
 ggaaactaat aaacgatact tgcattatgc caaaggtctc ccaatatatt gggagaaaag    600
 caaagccacc attgagatgg agattacaca agaaagagag catttcttgc gcagccaatc    660
 cagcaagagt ataggtttaa agccctaaat gccatgcgta tctttaaaaa attttatctt    720
 ttgaaacacg ttctgattaa ccaagggtaa gcatgttttg gttgctaaag aaaaaagcat    780
 aatctttaac cgagtataag tacttgctgt gtatttagtg taaaagtaca tgcagaaaga    840
 tgaaacacaa agtaattgat gtatttccat cttcttatat tttttagtcc aataattagg    900
 caaaatatta ctatggtact taaggggata cctgtgtagg tgttcggntt atatgtcagt    960
 tttttgccca ttacttcatc cctaaatctt cagcatgaac aaatattaat gtcgataata   1020
 aaacattggg actctttgga aatgtatgtt accattaatt tgctatttgg acctctaaat   1080
 ttgtaaaaat gcctcccaaa agtttattta tagggaccaa aaatacatga ggatggattt   1140
 gtcccaatgg ataaaaatgg cactattta                                     1169



      <210> 549
      <211> 403
      <212> DNA
      <213> Homo sapiens


      <400> 549
 cgaaggggac gccgggaaca gggccagctg aggggcccac ggacataggg cacccacaat     60
 aggcgtgtgt ctgctgtgtg tttgtgttcg gccgtcctgc ttctctgctt ccacacgtac    120
 acatgcccct gtgttacttt ggttcatctt ctgtactctg tcagttttct gctggtcaga    180
 acatctgtga ctgtgacaga gctgtccagg attgcagtgg ataggaattt cttcacatgg    240
 ctcctggaga agtgaccatc acagttcgcc tcatccgttc ctttgaacat cgcaatttca    300
 aacctgtagt gtatcacgga gtgaatttgg accaaactgt aaaggaattt atcgtatttc    360
 taaagcaaga tgcactaaag attattcatc aagcacataa atc                      403



      <210> 550
      <211> 2343
      <212> DNA
      <213> Homo sapiens


      <400> 550
 gagcatgacc tgcattacgc caagcttggc acgagggcaa cgggcggagg cggccgagga     60
 ccgtctgggc acaatgtttt tttggacgag ggcggcacgc ccctgctggc cgagagcctg    120
 gtctaccaga tcttcctgag cctgggcctg gccgatttgc tggccgccgg gctggtgtgc    180
 cgccaatggc aggccgtgtc gcgggacgag ttcctgtgga gggagcagtt ctaccgctac    240
 taccaggtgg cccgcgacgt gccccgacac ccagcggcca tgtcctggta cgaggagttc    300
 cagcggctgt atgacacggt gccctgcgtg gaggtgcaga cgctgaggga acacacagac    360
 caggtcctgc acctcagctt ctcccattcc gggtaccagt tcgcgtcctg ctccaaggac    420
 tgcactgtga acatctggag caacgacctg accatctcgc tgctgcacag cgcggacatg    480
 cggccctaca actggagcta cacccagttc tcccagttca acaaggacga ctcgctactg    540
 ctggcctcgg gggtgttcct ggggccgcac aactcctcat ccggcgagat tgctgtcatc    600
 agcctagact ccttcgcgct gctgtcccgc gtgcggaaca agccctatga cgtgtttggc    660
 tgttggctca ccgagaccag cctcatctcg gggaacctgc accgcatcgg agatatcacc    720
 tcctgctcgg tgctgtggct caacaatgcc ttccaggatg tggagtcaga gaacgtcaac    780
 gtggtgaagc ggctgttcaa gatccagaac ctcaatgcca gcaccgtccg cacggtgatg    840
 gtggccgact gcagccgctt cgacagccct gacctgctgc tggaagccgg tgacccggcc    900
 acgtccccct gccgcatctt tgacctgggc agcgacaacg aggaggtggt ggctgtgctc    960
 gccccccgcc cacgccaagg agggcttgcg gcactttctg gaccgcgtgc tggaggggcg   1020
 ggcgcagcca cagctgtcgg agcgcatgct agagaccaag gtggccgagc tgctggccca   1080
 gggccacacc aagccacccg agcgcagtgc cacaggcgcc aagagcaagt acctcatctt   1140
 caccactggc tgcctcacct actccccaca ccagatcggc atcaagcaga tcctgccaca   1200
 ccagatgacc acggcagggc ccgtgcttgg gtgagggccg gggctccgat tgccttcttc   1260
 gaccgccgct tggaccaccg tcatagacat acacgggaca catcatcggg catgggcctg   1320
 ttcgcccgac aacaggtacc tgtacgtgaa cagccgcgcc tggcccaacg ggtgcggtgg   1380
 tggcccgacc ccatgcagcc tgccaccaat cgcggaggag attgaccttg ctggtgttcg   1440
 acctcaatga ccatgcggga ggtgaggcgg gctctgcgtg cgcaccgcgc ctacacgccc   1500
 aacgacgagt gcttcttcat cttccttgga cgtcagcaag ggacttccgt ggccagcggg   1560
 gcggaaggac cggcacggct aacatcttgg gaccgccact acaacatctg gtctggccag   1620
 gctgcggcac gaggatgtgg tcaactcagt ggtcttcagt ccccaaggag caaggaggtg   1680
 ctgcttcacg gccaagggac acgccaccca tcaaaagctg ggcgctcccc acgcaccatg   1740
 ggcgtccttc agggcacctc gcccacggcc tcgcaccttc ttctcctggc ttgccagcca   1800
 gaggcgctga ggtgtgctgg gtgcaactgg agccaccggg accccttgag gacatcgcca   1860
 ggctctgtgg ctttttcccg agcggggaga ggtggagatg cttatagcag ttacgccttt   1920
 aggaaagggg acaaaccagg ccccggccac aacgctcaca acacaaaaac cttgtcacgg   1980
 cagctgtgat gcttggcacg gggtggccag tgcagatgga gcccaaaggc cccctcggcc   2040
 tcctgggcaa ctttggggta cacaaggata ctgggggtgc cgctcctcac tcaaacccca   2100
 ggctaggggt acaccctgac ccagctggcc tcggcccggg ggcaccttcg gctggtcctg   2160
 tggggccctg gacggttggc ccagtggtgg caggggctgc tcctggctgt ggttgctcgc   2220
 gcccgcggct tgggtgctgg ccggtcacgc tgctgtgggc ccgagtagtg ttgcatgtcc   2280
 acgcaccacc cgttcagggc cctgaataaa cagttggcaa cagcaaaaaa aaaaaaaaaa   2340
 aaa                                                                 2343



      <210> 551
      <211> 405
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(405)
      <223> n = a,t,c or g


      <400> 551
 ccttcttgtc tttctccttt ttctttggtt tgttctgctg gggctgagag agggctgcaa     60
 ntgctcgtgc acggctttga gctgctcctg gantcagcca gccgctgggt cgctcctcct    120
 cagagtcatc agtcgaactg tcactgtccn aggagctatc gctgctgctg ctcttctctg    180
 gtnctgggtg ctgctgagag tcgggcacgt ccttctttgg aggtttcaca ggccggctgc    240
 tctcccgccg ctggccagct tggtggtctt gggctccggg ggcagcgagg gtggctcgtg    300
 aatggggtca atggtggtgg gggtggtggt gtctgctttc ctcttcactc ccttctttgt    360
 cttcacaggc tgtggggtgg ccgcgatgat ggggtnggtg gctct                    405



      <210> 552
      <211> 400
      <212> DNA
      <213> Homo sapiens


      <400> 552
 aaagtataaa gtgttttgga aaaaaaggaa aaaaatctat ataaaaatct cttcacatat     60
 aaaatcctga agaaggtgca aggtgagacc cagtgcgagg ggcgtgctca gatatgcagt    120
 gtgtgtgtgt gtgtgtgtgt gtgtgtatcc gtgtgtacat gtgtgcacgt gtgtgcgtat    180
 gtgtctgtgt gtctgtgtgt gtgtgtgtga agctcagtgg agattcactg tgggggtcag    240
 ggatgtgcac gctgcatttg cctccagccc caagaagggg ggtgcactga gcaggctgtg    300
 gctctgcact gtgccgccca gctctggagg aacaggctta agctgatgaa gcagcctgtg    360
 gcccgggtct gatgggatct ctgcaacaac cccgtgttgc                          400



      <210> 553
      <211> 450
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(450)
      <223> n = a,t,c or g


      <400> 553
 ctggtgccgc tcactgagag gatgacaaga gggccagctt gctttgggag agcactggga     60
 atatctgccg catcatcacc tctggaagaa tttcctttgc cctgatgaat acaccgctgt    120
 ctaaattaat ccatcgacat cacacttacc ccacagtggg gctcctgagc catggacaat    180
 gatccatccc tttgagcttt ttttggtttt aaagtgcgta gtggnnnnnn nnnnnnnnnn    240
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    300
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    360
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    420
 nnnnnnnnnn nnnnnnnnnt ccccgaccga                                     450



      <210> 554
      <211> 468
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(468)
      <223> n = a,t,c or g


      <400> 554
 ttttttacgc ctctctcact ggtctgggca tnggatgttt ctgttgaagc catagcagca     60
 ctggcttctt ggttaagaga agttatggtt tccaatatcg acatggcatc attggctaca    120
 ttagcactgg gcccaggagt aggaacacct gaggtctgaa tgtgtggttg atctttgggt    180
 ccacaacctg agaaataatt cggtcaatac cagactccaa cattcctgat ttgaggactt    240
 gttgtctaat gttgtttctt agctggttct tattgagatg cggactccat gtgtgagttg    300
 ccaagtgatt tgcaacaaag ttgtcaacac gctgtctcag attctgatac gcaggcttgg    360
 tgtccacgtc ggccaggcag tctctgcgga actggtcgaa gagcccctgg ctcttgaggt    420
 ggttcacgag ttatagatcg cgggcggccg ctcgcgatct agaactag                 468



      <210> 555
      <211> 468
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(468)
      <223> n = a,t,c or g


      <400> 555
 ttttttacgc ctctctcact ggtctgggca tnggatgttt ctgttgaagc catagcagca     60
 ctggcttctt ggttaagaga agttatggtt tccaatatcg acatggcatc attggctaca    120
 ttagcactgg gcccaggagt aggaacacct gaggtctgaa tgtgtggttg atctttgggt    180
 ccacaacctg agaaataatt cggtcaatac cagactccaa cattcctgat ttgaggactt    240
 gttgtctaat gttgtttctt agctggttct tattgagatg cggactccat gtgtgagttg    300
 ccaagtgatt tgcaacaaag ttgtcaacac gctgtctcag attctgatac gcaggcttgg    360
 tgtccacgtc ggccaggcag tctctgcgga actggtcgaa gagcccctgg ctcttgaggt    420
 ggttcacgag ttatagatcg cgggcggccg ctcgcgatct agaactag                 468



      <210> 556
      <211> 825
      <212> DNA
      <213> Homo sapiens


      <400> 556
 ttagcaccga gcagcagcgc aggagcgcca gaagggcggg agcacacggg cccttcccca     60
 cagccagcgc ctccgcgggt cccacccctc gagggcgggg ccgaccgctc tttccgggtt    120
 tgcgagcgga agtggacgaa tttgaatcct gtgggccgtt gaatgtggct gctcgcggtc    180
 ggcgtgcccc gacgtacagc gggccgggaa aagtggcact gaggctctgg aacttctgcc    240
 cagctctcct tggtgagtaa atggggaacg ggaagacgca gaacgttcca gagagagaag    300
 caggaccgtg gggtgggaga gggtgtcagg aggccggacg tcgcagccgg ggcctcgcag    360
 tgcttttggg gacgtctggt gctggggccc ggcctggaga ctaagggaat tcggggcact    420
 gggggcgttt gctggaccag cgctctcgac ggttgcgcac gccagccagc tctcagtgtt    480
 gaggattcgg aggcccttga aggatttgtt caacaatgct gattcctgca cttcagatct    540
 cagattctga atcagtaggt ctggaggatg gcattgaaca gtctgcatat ttaactgaaa    600
 ggttagaaaa tactgtgagt tttcaaaaca ctgatttgat ctttcatgat tatgtagtgt    660
 gaacagtccc attatctgtt tgcaaactgg agacccagga aagtcccgca gtgtagtttg    720
 aatgtctgga gccaaacagc tgatggtata ggttccagtc cggatctgaa ggccctcctg    780
 cgtcaggtag accccagtgt ctcttgtttc cttctttgtg ttcat                    825



      <210> 557
      <211> 418
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(418)
      <223> n = a,t,c or g


      <400> 557
 tacgccacgc ttggcacgag gcagcagatc gaggtggcca ggcagctcat agatgagaaa     60
 gttggcggga ccaatctcgg agcacctgga gccttcggac agagtccatt cagccagcca    120
 cctgccccac ctcatcaaaa tacctttcct ccaaggagct ccgggtgctt cccaaacatg    180
 gctgccaagg tgaatgggaa cccccacagc acccctgtga gtggtcctcc ggcctttctg    240
 acccagggct ggggcagcac ctaccaggcg tggcagcagc ccacacagca ggtcccaagt    300
 cacgccgcca gcgctgctcc tcaggccagc tccccaccgg actacacaat ggcctgggca    360
 gaatattaca gacagcaggt cgctttctac ggacagacgt tagggcaggc gcaggccn      418



      <210> 558
      <211> 454
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(454)
      <223> n = a,t,c or g


      <400> 558
 agctccttct ctgctcatga aatgcggctg gacttttcaa aggcggcatg atcccttggc     60
 tcaccagttc ttcccgggtc cggcgctgct ggagtttcaa ctgtagcaca ttcttccgct    120
 cactaagtgg aggcaaattg ggattcctgc cagggtggag gcctagggtc agctcgggct    180
 gcaaggagag ctcctgcagt tcattggcaa cagcttcact ctggggactg ggtgccgcag    240
 ataaggacac gagcactggt tcatcatcat tttcgccggc ccctcctccg tccagcccat    300
 tcacagcaat gacggaaggg ggcaggcaca ccacactgga gaaatccact ttggctttcg    360
 tgatggcaat cgcctcgcgc ggctcaaggc cgggttccgc ggctcgcccc actccggctc    420
 tagccgcccg cgtgtcctct cgacnaagaa tccg                                454



      <210> 559
      <211> 1056
      <212> DNA
      <213> Homo sapiens


      <400> 559
 ggccctactg caagtagtaa cagtaacccc gtcgaacagg gttctgcaat aggtgaactc     60
 tctcacatgt atatttcatt tattcgaccc gaatagttaa caaagtctct ggcagcattg    120
 cttagcgcat cttttttatt ggtggaattt cccatcccac attttccaag tccatgcaca    180
 tcaccttcag gcatgaatct atgcccgttg gggctcccca ctgctctaat ttcataggat    240
 ggggtcatct tccttttgcc acaccaggca tacagaaaat ttttagcgtc acccatgatt    300
 caagtgtctt cttcagatca gccttcgctt cctggtgccc agctcttagg accgtgtgtg    360
 actctggcct tctaccgaga caattgagaa acgcacagca actcgcatgg aggaatcggc    420
 gaaatggctc cgaccgcggc gctagggggc ggggccagcg agcgtacgca tgcgcagagc    480
 gcgtgccagg gcgggggatg gcgagggcgc gccaatggag ggggcggggc tcagcaacct    540
 cgcggcgcgg aagggtttcg ttgctaggga gatgggctga gccgggcggg catcgcgcca    600
 gacctgctac tctggataat ccactctcct ggataatcca ctaccctgga taatcggctg    660
 cccgcttttg cgcatgttag ggagttgacg gcctgtagca ttctgatgca gcaaaatatt    720
 tcgcagggtc tgtcataggg atctccggtg agaggaggtt cccttcgaag gcagaactgg    780
 aaaccttgct gctaacttgg tagggttgtt gagataatta catgagatgg catatgaagg    840
 gcggcttagt tcaatacctg gcatgtagta ggtgttcagt gggcgtagtt accggattga    900
 ttcagatagt ctgaacgcca gtgtctcttg aaagaaataa actggccggg cgtggtgact    960
 gtaatcccag cactttggga ggccgaggtg ggcgaatcac ttggggtcag gagtttgaga   1020
 ccagcctggc cagcgtggtg aaaccccgtt tctact                             1056



      <210> 560
      <211> 4444
      <212> DNA
      <213> Homo sapiens


      <400> 560
 acatcatacg ccaagcttgg cacgaggcct cgtgccaagc ttggcacgag gatggagtca     60
 caaaggtaca cgtcttagac agagaaatca aagttaacat ctttgatatg gctggacatc    120
 ccttcttcta tgaggttcga aatgagtttt acaaggacac acagggtgtg attactggtc    180
 tatgatgttg ggcagaaaga ctcctttgac gcccttgatg cgtggctggc agaaatgaag    240
 caagagcttg ggacctcatg ggaaacatgg gaaaatatta tatttgtagt ttgtgccaac    300
 aagattgatt gtaccaaaca tcgctgtgta ggatggaaag tggaaggacg tctttggggc    360
 tggaagcaaa agggttcctg ttacttttga aactttcagg cacaaactgg gaggagggct    420
 ttattgaggt gtttccagac cttttatata tccatagttg atttatgtga aaatggcggg    480
 aaacgcccta ccaccaatag cagtgctagt ttcaccaaag aacaagcaga tgccattcgc    540
 agaattcgaa atagtaaaga cagttgggac atgctgggag tcaaacctgg ggcctcaagg    600
 gatgaagtca ataaagcgta tcggaaactt gctgtgcttc ttcaccctga caaatgtgta    660
 gcacctggca gtgaagatgc cttcaaagca gttgtgaatg ctcggacagc cctcctgaaa    720
 aacatcaagt agaaagtaca gaaaaaagcc acatgtggga ctcaaatgca aacagacttt    780
 ccctagaggt gaaataacca acggggaggt tttcttccca aaaatctcac tgctcttttc    840
 attcatgtgt tggcatttgt atatcagtaa ttcaggtacc catttcatag acattttact    900
 gagaaatgac ctgcatttgt atgaagtgaa ctgagcgtca caccctgtac ttcatttcat    960
 atttctagat aattctgaat ttttttctca ttcgtcagct ctgtaattat agtatcactt   1020
 agacatttca cttggggaaa tccacaaggt tcctggaggg agggaagaga ggacaaaagg   1080
 accctttcac tttttctttt ttacggaatt catcatcaga gaagaaaata acaaaaatgg   1140
 aagcaaacaa catcagaacc cctgtaagtt tggtgtgacc ttacagacaa gttgctgctt   1200
 ttacaatgag ttccttaggt ggtattttaa cccatcgatc taataatgat gaactcctgg   1260
 gccaacccct ttgggaagtt ttgtaaaaaa tgaaggtgaa taacagttcc tgaaattgag   1320
 caatcccctt ttatgaatat tcactctgtt ccctcttctg cagcccaccc agtgggagag   1380
 acaagcccag tccctaagag aaaaggtggt ggcagccaca aattctaggt acactggctg   1440
 ctgccctatc ctgtcccctg gatctgaggc ctttcccttg ccatagaaat ggttgctggt   1500
 agcagtagag agcactgtgc acctgggaat gaggaatcag gccccaagac agaagtactt   1560
 ggaggagcca gctgcagtag tatccgcctg tagtcccagc tactcaggag gctgagacag   1620
 gaggattgct taagcccagg agctcaagtc ccacctgggc aacatagtaa gatcttgtct   1680
 cttaaagaaa aaaaaaaaag gtacttagag gtcgcactta aagattatgc acatcagcag   1740
 aggaaaggcc agccaagctt ggggcaagct tgatgcagta ggagagactc cttatgaggc   1800
 ttagcccttg tcttactgcc agcctttgcc acaggcaggt gagaaaggca gggccactcc   1860
 tcagcaaagt tggcctcttc tacacttcct caccagtgtt gtttcttcct tttttcccct   1920
 cttccccttc ccgtcttgtg ttttttctga accccacatc tgccatcatt tctctcctct   1980
 agagtccctg gcttctggcc actgcctcct ccctcttcta agccttggcc tgaatctggt   2040
 tgatcagagg caagtgtgga tcctttgggt ggcagtcagg ggagatctca gggcctctgt   2100
 tgggaggaat ctctgtaatt cctgcttggg ctccaaattt ctgaagagta atatttttaa   2160
 actatagctt acaaaataca ttctctgacc acagtctcct ccttgatata caagggatgg   2220
 atgaagttca tgtattagga ctggcactcc ttacggtgct tatagaacta gtctcaccac   2280
 ttgactcatt acgtcgtcat tcttgttaca tcactcatac ttttagctgc aaccacacta   2340
 attcacattt ttatatactt tcaattagct gtactaattg gggcttgaaa gtatataaaa   2400
 tcttcctgtc ctgtgaattt taaaaagcta tcccatatcg attgccaaag agcatctacc   2460
 ttacctccta agaagaaaag ccactttctt ccaatccaag cccactgcag ccttgtggat   2520
 tttccacaca gcagcttttc actgtatgcc tgtacttggg ctgcactgag cttgtcttca   2580
 ggaaaccaga gcgttgcttt atcatcgcac ttttcatctt ggtaatatca aaacaacttt   2640
 ttaaatgaac tgattgatat atgttatttc ttgcgaggtt ttcctctggc ctttaactgg   2700
 cttctgaggc tacagaactc caacccagag ttcttcggga cctaaatttt gcttaaggaa   2760
 ggcctttatc atgctgaaag cactcagaca tgtctgtcct cacagcagaa tgtagaagtc   2820
 atatgaatga gggatcgtgc acggtagcgt cagcccgaat tgacacgaca actctgaatg   2880
 tgtggcccac tatgaaagct ggtgccagtt ttcatcactg ttattaaata ctagattggg   2940
 aacctcattc agccgtattg cacagatgag caattacagc agagaaaatt cattagtgct   3000
 cccactcata tccttatgtg tgagttggtg aaatttagcc tgagcttgat tcttaggtct   3060
 tgagactcag tttccaacac cttcattatt aatgttaaga atggccatat accacttcat   3120
 ttacgtaaaa ggaataaaat aagcaagtta agcttcaggg tcctagaatt tttctgattt   3180
 ctataatcct tcagcagaat attaagaaat aaagcatgat ctgcaatgga aaggtttttt   3240
 tggcactaac ttcatgcaga atttcacaga catctatgca ttaatttaaa ttcttggtgc   3300
 aaatgtgtgc tttgtagttc aaccttatta aaaattcttc agccagttag gatttcaaaa   3360
 tacattagtg agagtaacag ctagcagaat aattacaatg gctaaaacgt ttttatagag   3420
 aatcttgttt ttcaaaaaag aataaaaagt ttgaatagct attattaaag aaaagccatg   3480
 tcttcaacat ctgagtcacc aagaagtaac actttttaaa cttgttagaa atccctggag   3540
 gcatttccaa attccatctt ctaacctacc ttaggcactt ttaaaataca gcctccttcg   3600
 ggtccctctg gttccccctt caggcctcct tttggaaatg gatatctcag ctgtccaata   3660
 tttctttgga cttccagcca ttgttatttt atttctctat atcaatgtgt ccttagtttt   3720
 cttagcctgt taatttaaaa atcccagact tgggggtcat tgtgttgctt acccaagaga   3780
 aaaatgttac agttttatag attgcacatc attctttaag gcatactttt acctcaggaa   3840
 acttactcta gtatgttctc atatattgaa ttctcaacta agtaactatt tctttatacc   3900
 tataaactag tacctaattc actgttagtt aaatgagcta tagataaggc agctaaattt   3960
 tctgaaagat agccagagta agtaagcagc cactgcaagc tctgaatcag ttttttaaaa   4020
 aaaaagaaaa aaaaaaaaaa ggagctgtgc cccattgaac aatgacaaca tcacaagggg   4080
 aagggaggga ttttgccaaa agttagaaag gtggagctgc taggccatgt gcttgttgcc   4140
 tttgacagtg acagtgcgcg tcttacaact aattccacta ggcatggtaa tgtcaccttc   4200
 tttgccactg taccctatca agcttactct gaatcaaagt gttttgtaga acttttgaaa   4260
 atgaacatta gcttgcctat atatgctaac cactttccat tgcaagcttc tctattgact   4320
 ctcggtctgt tctttatatt actttcatta tcctctttgt atctctagtt cactatctct   4380
 tgtatatata tatattcata ctcctatatt tcttttcttt cattttcatc tattatgctt   4440
 ctct                                                                4444



      <210> 561
      <211> 721
      <212> DNA
      <213> Homo sapiens


      <400> 561
 cactgtttgt caacacacac aatacaagga aagcagggag tctggggctt tttgcaggcg     60
 ggcctggggt ctcagtggag gggacaaagg caagcaaaag cccatgtcca ggagccctgg    120
 gttgtcccca caggcctcgc ctcaaaagag cctcctttgg ggtgagcagc cttgtattgg    180
 ccacaggtgc actaaattga ctgtgaatcc caaacctccc cagaccagcc aggccgcctg    240
 cccccaccca gaaccttccg gtttgccctg tatggaaagc cactctcaga aatccctctt    300
 tcctgagtca gcaatcgtgg caaggggaca tgtgttccaa cagcggctgg ggagtggacc    360
 tctctgtccc ttgcccacct taagccccaa atccagaccc cctctgacat cactggcatt    420
 gcacctgggt gtgcccccct ccccacgcta tggacccaga taggaggggt taggcatggg    480
 ggaggcacag aatgctggag agatgcgtcc tggtgaaccg tggggcaagc cctcccaagg    540
 acccccaaca gaactggcct taggttttgt cagccccact ccctttcctt cccctctgcc    600
 tcccacccac tctgggggtc cacatcaaga tagctgggcc cagtgtggaa gcccaacgtg    660
 tctgttctag cagaaaggac acaagcctgg tgttctggag acctcggctc aagtctttgc    720
 c                                                                    721



      <210> 562
      <211> 518
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(518)
      <223> n = a,t,c or g


      <400> 562
 ntatacccgt accactccct gacacgcata gagaaggtat tgatgtcctt atccagctgg     60
 tccaggaggc taatggactg gatgatcata ttgtccaccc ggttcacatt aaacttaact    120
 ttggcacggg aatagctgtg tcccagcccc agctgtgctt tacaagctga cagatcggtc    180
 agacccttca ccagattgtg gaagtgcaga cgaactcctc gcaggatctc agctatgact    240
 cctccagtct ggcagttgta ccctaactcc tcctgtattg cggcaccaat cttgggatcc    300
 ccaactccca agagtacttt cttctttttg gacggcaggt gggtctccaa gagcagactg    360
 atctcctcca cttccttcag cgccagcagc gcgtagccga ccgcgtgctc aaacagcacg    420
 tgcaacagca ccatggcgcc atctgccggg ttcgcggacg cgtgggtcga cccggggttc    480
 cggcgcaggg ccctcaagtn ttctattnng gggcagcg                            518



      <210> 563
      <211> 367
      <212> DNA
      <213> Homo sapiens


      <400> 563
 ggcacgagga tggaataagg tttccccaac agaactgcgc ttcccaagaa tgggaataag     60
 aatgggggtg aggccagcat ggtgcggggg tgtctagaga gagcagaaac ctgaggctgt    120
 cccaatggca tgccacaggg ggaacgcctg agccgctttg gactccgcac agagaccaca    180
 ggcactgtca ccttccgctt gcactgtctg cagcagtcca ggtgagtgac ttggccctct    240
 gcctcagggc acctttagcc ctgaggggtg gagacagccg taaccatgtg gctggcctcc    300
 ctgcagggcc ttcatggaat cgagctccct tcagaaaagg atgcggagtg tgttggaccc    360
 gctggaa                                                              367



      <210> 564
      <211> 367
      <212> DNA
      <213> Homo sapiens


      <400> 564
 ggcacgagga tggaataagg tttccccaac agaactgcgc ttcccaagaa tgggaataag     60
 aatgggggtg aggccagcat ggtgcggggg tgtctagaga gagcagaaac ctgaggctgt    120
 cccaatggca tgccacaggg ggaacgcctg agccgctttg gactccgcac agagaccaca    180
 ggcactgtca ccttccgctt gcactgtctg cagcagtcca ggtgagtgac ttggccctct    240
 gcctcagggc acctttagcc ctgaggggtg gagacagccg taaccatgtg gctggcctcc    300
 ctgcagggcc ttcatggaat cgagctccct tcagaaaagg atgcggagtg tgttggaccc    360
 gctggaa                                                              367



      <210> 565
      <211> 496
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(496)
      <223> n = a,t,c or g


      <400> 565
 gcaactcctc gcacgtggcc atctcggcgc ctgtctntgc acagcctgtt gatgccagcg     60
 tggggctggc ctggctggcc gtgggcagca tgtgcctctt catcgccggc tttgcggtgg    120
 gctgggggcc catcccctgg ctcctcatgt cagagatctt ccctctgcat gtcaagggcg    180
 tggcgacagg catctgcgtc ctcaccaact ggctcatggc ctttctcgtg accaaggagt    240
 tcagcagcct catgctcctg ctgctgctct gaggactcag gaacaccttc gagctttgca    300
 gacctgcggt cagccctcca tgcgcaagac taaagcagcg gaagaggagg tgggcctcta    360
 ggatctttgt cttctggctg gaggtgcttt tggaggttgg gtgctgggca ttcagtcgct    420
 cctctcacgc ggctgcctta tcgggaagga aatttgtttg ccaaataaag actgacacag    480
 aaaatcaaaa aaaaaa                                                    496



      <210> 566
      <211> 496
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(496)
      <223> n = a,t,c or g


      <400> 566
 gcaactcctc gcacgtggcc atctcggcgc ctgtctntgc acagcctgtt gatgccagcg     60
 tggggctggc ctggctggcc gtgggcagca tgtgcctctt catcgccggc tttgcggtgg    120
 gctgggggcc catcccctgg ctcctcatgt cagagatctt ccctctgcat gtcaagggcg    180
 tggcgacagg catctgcgtc ctcaccaact ggctcatggc ctttctcgtg accaaggagt    240
 tcagcagcct catgctcctg ctgctgctct gaggactcag gaacaccttc gagctttgca    300
 gacctgcggt cagccctcca tgcgcaagac taaagcagcg gaagaggagg tgggcctcta    360
 ggatctttgt cttctggctg gaggtgcttt tggaggttgg gtgctgggca ttcagtcgct    420
 cctctcacgc ggctgcctta tcgggaagga aatttgtttg ccaaataaag actgacacag    480
 aaaatcaaaa aaaaaa                                                    496



      <210> 567
      <211> 470
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(470)
      <223> n = a,t,c or g


      <400> 567
 gacaacgtga agatcatctg cctgggagac agcgcagtgg gcaaatccaa actcatggag     60
 agatttctca tggatggctt tcagccacag cagctgtcca cgtacgccct gaccctgtac    120
 aagcacacag ccacggtaga tggcaagacc atccttgtgg cagacataaa cgtgacccaa    180
 aaaagcttca attttgccaa gaagttctcc ctgcccctgt atttcgtctc ggctgctgat    240
 ggtaccaatg ttgtgaagct cttcaatgat gcaattcgat tagctgtgtc ttacaaacag    300
 aactcccagg acttcatgga tgagattttt caggagctcg agaacttcag cttggagcag    360
 gaagaggaga acgtgccaga ccaggaacag agcagcagca tcgagncccc gccctcgtcc    420
 caagctaggc gtattgagac gacgccaatc catggccncc ccccgcttnn               470



      <210> 568
      <211> 470
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(470)
      <223> n = a,t,c or g


      <400> 568
 gacaacgtga agatcatctg cctgggagac agcgcagtgg gcaaatccaa actcatggag     60
 agatttctca tggatggctt tcagccacag cagctgtcca cgtacgccct gaccctgtac    120
 aagcacacag ccacggtaga tggcaagacc atccttgtgg cagacataaa cgtgacccaa    180
 aaaagcttca attttgccaa gaagttctcc ctgcccctgt atttcgtctc ggctgctgat    240
 ggtaccaatg ttgtgaagct cttcaatgat gcaattcgat tagctgtgtc ttacaaacag    300
 aactcccagg acttcatgga tgagattttt caggagctcg agaacttcag cttggagcag    360
 gaagaggaga acgtgccaga ccaggaacag agcagcagca tcgagncccc gccctcgtcc    420
 caagctaggc gtattgagac gacgccaatc catggccncc ccccgcttnn               470



      <210> 569
      <211> 470
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(470)
      <223> n = a,t,c or g


      <400> 569
 gacaacgtga agatcatctg cctgggagac agcgcagtgg gcaaatccaa actcatggag     60
 agatttctca tggatggctt tcagccacag cagctgtcca cgtacgccct gaccctgtac    120
 aagcacacag ccacggtaga tggcaagacc atccttgtgg cagacataaa cgtgacccaa    180
 aaaagcttca attttgccaa gaagttctcc ctgcccctgt atttcgtctc ggctgctgat    240
 ggtaccaatg ttgtgaagct cttcaatgat gcaattcgat tagctgtgtc ttacaaacag    300
 aactcccagg acttcatgga tgagattttt caggagctcg agaacttcag cttggagcag    360
 gaagaggaga acgtgccaga ccaggaacag agcagcagca tcgagncccc gccctcgtcc    420
 caagctaggc gtattgagac gacgccaatc catggccncc ccccgcttnn               470



      <210> 570
      <211> 502
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(502)
      <223> n = a,t,c or g


      <400> 570
 ggcacgaggg gcaaagagaa agcaaagcag ctgcgctcag acctgagctc ctttgacatg     60
 ttaagatatg ttgaaactct actcacacat atgggtgtaa atccgctaga agctgaagaa    120
 ctcatccgtg atgaagatag tcctgatttt gaattcatag tctatgactc ctggaagata    180
 acaggcagaa cagcagaaaa cacctttaat aaaacccata cattccactt tctgttgggt    240
 tcaatatacg gagagtgccc tgtgccaaag ccacgagttg atcgtccaag aaaagttcct    300
 gtgatacaag aggagagggc aatgcctgcc cacctgatac ccccaatgtc cttctttgac    360
 tttgtgggtg atcctcattc tttcccccgt acagtggaaa acatctttca tgtttccttc    420
 attatacggg atggtnttgc agaataaact tgaccaagac cgactgccag taatagagcc    480
 tgttagtatt aatgaagaaa an                                             502



      <210> 571
      <211> 1405
      <212> DNA
      <213> Homo sapiens


      <400> 571
 ggttttgcct cctgtgactt aattcctgtg cagaatttgg tttgttttta caatctagcc     60
 ttgacctggc cttcagactt ggtttctagc tcatcctccc caaaactgca tgttttatcc    120
 cagtggttct taattctcaa catccatagt cctgcgcaga atcttaaagt ttggttaagt    180
 gaaacagatt ttagaattta gtgtatatct caaaggtcag aattaagaaa ttgccatgtt    240
 tcttcaggtg gtttatgaaa taccagcatg tagacccaga agaagctgta aggattcaca    300
 ctgatgtcca aacaaagaaa tctatggcaa ttcactgggg aacttttgcc ttagcaaatg    360
 agcattactt agagcctcca gtgaagctga atgaagctct agagagatac ggacttaacg    420
 ctgaagattt ttttgtcttg aagcatggag aatcaagata cctaaataat aatgatgaaa    480
 acttttaata aatgtgagca caggcacttt taatgaaaaa ggcatcatct aagtttaaaa    540
 acaaatgaaa agacttagaa attcatgaat attgtgatta ttttacattt ggaaacaact    600
 tctgcaagtt tatgttttat gttttgtgta ataacttgct tcctagtatg atcagctcat    660
 gtacactatg agagggttca ggggtgggtc atttaaataa tgaattggct aatgtggatt    720
 ttaaatttca tatcatgata taagcactgc aatggaaatg tttttactaa aacattatat    780
 ttttgtggta ctagaatttc ctgaggtgaa aaaccgatat tgaagattca tttttctttt    840
 ttccattctt caggaccttc ggcaaggtga gtcaaggctc tctacctacc tagatgtttt    900
 tcagaggcct acaaatacaa gtatctttct tatatgcaca ttctaataaa tgatgaaatt    960
 cagtccaaca tgcttattat aaacatagca attcttgctc tatcaaatta gcttatatgc   1020
 caaatattaa atatcggttt atttaggtaa gcataaaaac ataggggcta tcatttttaa   1080
 agacttgatt ttcccctatt gggggaaaat atataaatac atatttgccc attttaaaca   1140
 tttacccatt ttaacccatt tttaagtgta cagttctttc gcattaatgc acccatgacc   1200
 caccattcac ttaaattttt aaaagaacag tatattcttt ttttcctaga agccttcaga   1260
 tgagagggaa cagtatattc tattgcacgt ctacaattcc caaaagacct cttactttgg   1320
 gaggccaagg tgggtgggtc acttgaaccc aggagttttg acatcaacct gggcaacatg   1380
 ggtgacctcc cgtctctctc ggaaa                                         1405



      <210> 572
      <211> 3198
      <212> DNA
      <213> Homo sapiens


      <400> 572
 atggcatggc gtcggttgtc ccggcggcgt gtcgctggca atgaccggac atggcctgca     60
 ccacagcgac attggcggta caccaccctg tttgagatga agcgcagcaa agagctgcct    120
 gtgcgctggt gcgatttcag cgccttcacg ccgatgatgc gcacccacga aggtaaccgt    180
 cctggcgaca actggcagtt tgacggcgac gcagaaacca tcgcccattt cgcccgtatg    240
 accaccgtct tcaccaccct gaaaccttac ctgaaagagg ccgtcgcgct gaatgcgaag    300
 tccggcctgc cgcaacttgt ggatatcaga gaggagatgc cagagcagac agccaaacga    360
 atgttgagcc ttcttggtat tcttaagtac aaaccttcag gaaatgccac agatatgggt    420
 aaagaacacc ggactttgcc agctaatttc gcgtttaatg aattcgtagc gcggcacctg    480
 cgacaccgcc gcacggttaa ccagctccag ccgggagaaa atcacctggg tggtggtgtc    540
 gcggtcgcgt cttcttttgg caccagcatc atcgccacgc caatcgccgt tacgccgccg    600
 atcaacttgc cgacaatcat cgggaagatc atggcgttca tgttggcagc ggcgaagcct    660
 aagtggtcgc ccagggcgaa agcagcggaa acggcgaagg cgcagttgat gactttgccg    720
 cggaactcgg tgatcttgtt tgcaagcagg ctctcatccc acgctcctgc agggctccaa    780
 ggtcacatta actttactat tagtacaaag attctggaca gcaatgaacc atgtgggggc    840
 cagaaggggt ttgttcccca aaagggccga agtgacacgc tcatcaagcc agttctcgtc    900
 aaagacccaa tggtgagtca gggtctacgg tgtctcaaga attcggccac ctccacgacc    960
 aacctctaca cacaggccct gttggcttac attttctccc tggctgggga aatggacatc   1020
 agaaacattc tccttaaaca gttagatcaa caggctatca tctcaggatt cattttagta   1080
 acagttatta agtcatcaaa tgctgatgac acatcaatct acatgtttta tcaaaaggtc   1140
 ggcgacaact caatcgacag ctggaaaaac gcgggccgtg tctttaaaga cagcgataag   1200
 ttcgacgcca acgatccgat cctgaaagat cagacgcaag aatggtccgg ttgtgatccc   1260
 cagctcggat gcgatttcgt cgtatctgaa gcgagggctt tcgcgtcgga tcatcgccaa   1320
 gccgaatgga gcagcaaaga cgactttatg cgtctgggta aaccgattct gtttttcggt   1380
 gttactgctg gcaacatgga ttcgatgatc aaccgttata ccgccgatcg ccgtttacgt   1440
 catgacgatg cctacacgcc ggataacgtc gcgggtaagc gcccggatcg cgccacactg   1500
 gtttataccc agcgttgtaa agaggcgtgg aaagatgtac cggtgatcct cggcggtatt   1560
 gaggctagtc tgcgccgtac cgcgcattat gattactggt ccgataccgt gcgccgttcc   1620
 gtgctggtgg attcgaaagc cgacatgctg atgtttggta acggtgagcg tccgctggtg   1680
 gaagtggcgc atcgtctggc gatgggcgag ccaattagtg aaatccgcga tgtgcgtaat   1740
 accgcgatta tcgtgaaaga ggcgctgcct ggctggagcg gcgtggattc cacccgtctt   1800
 gatacccctg gaaaaatcga cccaatcccg catccgtatg gtgaagattt gcctcctgtg   1860
 cgttcagacg aacaggctga agcactgccg gaagcgtatg aaccgattga ggttaacgaa   1920
 ttcggtgaaa tcgatctgct tgcaatggtt gaagatgaaa tcatcctcgc cttgccggta   1980
 gttccggtgc atgattctga acactgtgaa gtgtccgaag cggacatggt ctttggtgaa   2040
 ctgcctgaag aagcgcaaaa gccaaaccca tttgccgtat tagccagctt aaagcgagta   2100
 aggtccatgg ccgtacaaca gaataaacca acccgttcca aacgtggcat gcgtcgttcc   2160
 catgacgcgc tgaccgcagt caccagcctg tctgtagaca aaacttctgg tgaaaaacac   2220
 ctgcgtcacc acatcactgc cgacggttac taccgcggcc gcaaggtggt gtgggatgat   2280
 gtgctcatga gtgaacaagg gaagcagcta gcttccaggt gtctaatatc ctgggatgga   2340
 tgtgtgtggc atgacctgct gatgaaagat gcggctcttc tgcgtctgga ggccaatgca   2400
 aatgtaggtt catccagcac tggggagtac tatgggatgt tccaattctg gtatggtcac   2460
 tacccctatc aagtggctga gtatgatcag tgtccagtgt ctggccaatg gaactttcct   2520
 cagcccttca ttgaccaaat gccccaaggg cattcgagcc agcgttccat tatctggagg   2580
 ccctcgttct ctgaaggcac ggaccttttc agctttttcc ggccagccat ccagccagcc   2640
 atccagccag ccaaccaact atccatccac aatttgtgga cacaattccg gcattcaacc   2700
 aaaattccag ttgaatgggt gaatggtgaa tggctgaatg gacgaatgcc aggggatcat   2760
 catgaatggc aatgcaacta tcaggaccca atggtgagtc agggtctacg gtgtctcaag   2820
 aattcggcca cctccacgac caacctctac acacaggccc tgttggctta cattttctcc   2880
 ctggctgggg aaatggacat cagaaacatt ctccttaaac agttagatca acaggctatc   2940
 atctcagatt taccacacat gaaagctgcc aaagcttatg gctggcatcc tctgaagcag   3000
 cagccccagt tgcagctgga cccctttgag ccacagctgg agctggagca gctgggatgc   3060
 aggaaacagt gtttggaggc tgtgcagcag cttccaggag cagaagtgga gctgcagctg   3120
 caggcagctc ccggatccct gaggcgctcc gggcggtgga tgagagtgtc ttactgctta   3180
 ggccagacaa agagctga                                                 3198



      <210> 573
      <211> 429
      <212> DNA
      <213> Homo sapiens


      <400> 573
 cccacgcgtc cgtgctaccc ccgcggagtt gtcgtgtgtt ctggattcat tccggcacca     60
 ccatgtcgaa ggtgtccttt aagatcacgc tgacggcgga cccacggctg ccgtacaaag    120
 tactcagtgt tgctgaaagt acacctttca cagcagtctt aaatgcctgt atgcagaaca    180
 ctgtacagtc tctgctgggg cggtgcaacc attaccagcc aggcaacact gatttagccc    240
 tgcggatact ggagagcttg ccgttgtcat tctggcctac tgaaaatgaa gtgatttaaa    300
 attgcaaatt tttgttactt caggagatgt taatatataa ttttattaaa aaggtttatt    360
 gaaaatcgtg aggcacttta ttgtatggat gcctttaaac ttagtagaca aaggtttctt    420
 tttttctta                                                            429



      <210> 574
      <211> 1490
      <212> DNA
      <213> Homo sapiens


      <400> 574
 cggacgcgtg ggcgagaaac caaaccacac accaaagaga ggggtatgat ggctaagaag     60
 cccccaaaac caggccctcg caggatcttc caggaaaggt taaagattac tgctctacct    120
 ttgtactttg aaggtttttt attaatcaag cggtcaggat accgggagta tgagcattac    180
 tggacagagt tgagaggaac tactcttttc ttttataccg acaaaaagag tataatatat    240
 gttgacaaat tagacatagt agacctcaca tgccttactg agcagaattc aactgaaaag    300
 aactgtgcga aattcaccct tgttttgccg aaagaggaag tacaactgaa gacagagaac    360
 acagaaagtg gggaagaatg gagaggcttc attcttacag taacagagct gtcagttccc    420
 caaaacgtgt cactcctacc tgggcaagta attaaactgc atgaagtcct agagagagaa    480
 aagaaaagga ggattgagac agagcagagt acgtccgtgg aaaaagagaa ggaaccaact    540
 gaagattatg tggatgtact gaaccctatg ccagcatgtt tttatacagt gtcccggaaa    600
 gaggcaactg agatgctcca gaagaaccct tctttgggaa atatgatcct gaggcctggt    660
 agtgacagta gaaactactc catcactatt cggcaggaga tagacattcc aagaatcaag    720
 cactacaaag tgatgagcgt aggacaaaac tacactattg aactggaaaa acctgtaaca    780
 ctcccaaacc ttttcagtgt cattgattat tttgtgaagg agactcgagg aaatttaaga    840
 ccatttatat gttcaactga tgaaaacact ggtcaagaac ccagtatgga agggagaagt    900
 gaaaagttga agaaaaatcc acacattgca tgaaatacaa tgtgaaagct cctttgtata    960
 tcttggtaat ttatattttc aaaacgaagt tcttactttt aaagagaatt acctatattc   1020
 tcctgatact gattaccaag tcattcacct gaacaccaga attagaatta aacattgtac   1080
 catacaattt cattatctta tcagaatgaa accaattcac agggaaacta gagactacgg   1140
 ctgtggtggt aacctgcaga tatacacatt cccatgcact gacataagtt gaaaacacat   1200
 agtactttct agatggaatt ttttttttta gggcctcaat gaaatacatt ttcccctata   1260
 taattccaac agcagtttct ctagttctaa attttaccaa ttcccaaaaa acctaagttt   1320
 tgctgaaatc tgatttgacc aatttatcaa atatgtcatt ttaattacct agctggaagt   1380
 tagagacatg aaatgtacta gaggagccct tttccaatgg aaatattata taccacattt   1440
 tttgttaatg gaaataaatg tctccattcc caaaaaaaaa aaaaaaaaaa              1490



      <210> 575
      <211> 371
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(371)
      <223> n = a,t,c or g


      <400> 575
 cagcatcggg ggcctgcaaa tctagtgccg aatgactatg tccagattgg tgacgatggg     60
 tgttgctgtt tttcttgtcg tttgtgaacg ctgtgatgct gtgtgcccaa gtgggcagtc    120
 accacccagc ccttccttgg gcgtctcccc cagagtgctg tcgggaccac atctgtcctc    180
 accctgtggg accgcctggc cctccctccc tagcccttcc agcctgggnn nnnnnnnnnn    240
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnntacctc tcatgcgtgt    300
 tttacctttt gatgttcaga gtggctcact ggctgagagt ccttatctcg gagagaggga    360
 gaggttggtt t                                                         371



      <210> 576
      <211> 976
      <212> DNA
      <213> Homo sapiens


      <400> 576
 aagggggaag ccaggggccc atttgggggc ccagccccca atcccaccca gcagaggaag     60
 ccaaggtcgg ggcagctgtg attgctccct ggtcctggag aggaaactgg ccatctgctt    120
 tatctgaaga ttttcagctg atgaagaact aggaggctca aacactatct tacctgagtc    180
 caggacaagt gacttggaga gtgtgctctt ctgtggcagg atcaggtctg tctagggcag    240
 gatggcccag gatctcagcg agaaggacct gttgaagatg gaggtggagc agctgaagaa    300
 agaagtgaaa aacacaagaa ttccgatttc caaagcggga aaggaaatca aggagtacgt    360
 ggaggcccaa gcaggaaacg atccttttct caaaggcatc cctgaggaca agaatccctt    420
 caaggagaaa ggtggctgtc tgataagctg atggcatgga gccctgccct gagtgtctgt    480
 ccctcttcag ccaagcccaa gtctcctaga cccccaggga gccagtgaac tgtcaccttc    540
 tcttcatcac agaatgagta aagatccctt gaacaattgc attgtgaacc catttcccca    600
 ttcccacctt tcactctttt tttccaatat ttcctccacc tgctgggtct ctgctgacct    660
 tgcttgggga cactttgagg gcagtgtggc ttggccgagc ggttgggccc atgggtggtg    720
 gggtgtgaaa agcctgcaat accccaagac cccagagggc agtccttagg aagcacttaa    780
 accaccctgg gaacccctcc gtcttttccc tctactctca tcctaggaat aaagcatttc    840
 cacgccagag tagtttgggc tgggggccag ggttgggtgg tcctgtccct ccatatcatg    900
 tcctacccta tggtcctgtt cctagtcatt tagatcaccc cagatggcct gatgacaaca    960
 agagtttgtg aagtta                                                    976



      <210> 577
      <211> 3083
      <212> DNA
      <213> Homo sapiens


      <400> 577
 cagcatcgca ggctttcctc cgagtccccg cgctgccgat ggacgtgctc cctttgcttg     60
 ttgtggagga tcctccaacg ggggcagcca gggggccggg gccagaccct acaacccacc    120
 agcccccaga ggtagctatt tttgcagcca gccgtgttga aggtggactt cggccagagc    180
 aggagaacag gagggacgcg ggacggcctc agatccggac gcccaagcag gggagggcag    240
 aacagacccg ccacccagcc agggtcagca gcggtggtgg tggctctcag gagcccacac    300
 aggtcaacac cttcatgtcc ttcatattcc ccatggtggt catctcggtc ctgaacacca    360
 tcatcgccaa caagctgacc gtcatggtac gccaggcggc cgagcagggc caagtgtgca    420
 cggtcggggg cgagcacagc acattcagca tggccatcga gcctggcagg gtccaggccc    480
 tgcggcacgg cgtgcgcgtc ctacgtgcag tggtcatcgc ctttgtggtc tgctggctgc    540
 cctaccacgt gcggcgcctc atgttctgct acatctcgga tgagcagtgg actccgttcc    600
 tctatgactt ctaccactac ttctacatgg tgaccaacgc actcttctac gtcagctcca    660
 ccatcaaccc catcctgtac aacctcgtct ctgccaactt ccgccacatc ttcctggcca    720
 cactggcctg cctctgcccg gccaaggccc aggggctctg ccaggacacc acatgggagg    780
 gggctcaggc ctcagcctca agatcttcag ctgtggcctc tcgggctcgg cagaagggac    840
 gccggatcag gggcctggtc tccagcacct gcccgagtgg ccgtggccag gatggggatc    900
 caggctccac agagcacatg actagccagg cccctggctt aagaaggtcg cctaagccta    960
 agagaagaca gtcccaggag aagctggccg ggaccagcca ggagctggga gccacaggaa   1020
 gcaaaagtag ggacacgtgt ccacgcacca cagacacacc cacgacacct gatctcgtat   1080
 cactagcttg cggccaggtc atgatgtggc cccggaagct ggccctgcgt gccatgagtg   1140
 cgtcggtcat ggagtccgga gcccctgagc cggcccctgg tgacggcaca gccctcacag   1200
 ctcaaacgcc cacccccact cccaccatct gcaggccagt gtccctcctg gcccagagcg   1260
 gtacccgggc cctcgactgc tgccctccac gggctccctg cctgaacctg tccacacccc   1320
 gattcgtccc cagagttgga cactccgtga tgtttaaggg atccctgggc tctgtgccaa   1380
 ggaggaagga gctggagcag cgaggcaaca aggcagatgg gcgggctcac gtcagaacca   1440
 ccagggagcc tgttccagac cagtttccca ggccccagct gagccccagg cgatcagaag   1500
 ggcataggag atcactgcac cccaaccgga ggaacactga cattgacgac aacatcatag   1560
 gaatggaaat acaaccatgg aattccagct cagtcatgga gcgggagatc tggggacact   1620
 ggccgggcag cctgccccag gcacccctga actccagtcc cctgaagcca gagcccgggc   1680
 caactaacca ggtgactagc agagccactg gggacacccc cagccaggcc cagaccccag   1740
 ccaattaccc agggcctgga gcaaggccct gtcagctcaa cccccatcat ctgacctggt   1800
 tcaaggccca tggccaccga gagccagtct gcagctgggc aaaagggcag acagggccag   1860
 gtgaggtgga cgtctcttgc acctacacat cctcgcgaca ggaggatgca cgtcgtacag   1920
 atggggaaac aggctgggaa agggagtgtg acctgcccgt gatcccagag gtgtggctac   1980
 cagagctgga actaaaaccg gagcccttca ccaaatccag ctcccaggac ctaagctggc   2040
 cttggatgaa cccagtacgg tgcctctcct gcctgtatcg gggcatccgg gcactgccag   2100
 cgtcccatta ctggactctg gtcaaggagc ttggggacag agtggccgcc gaggggacgg   2160
 agcctgccgt gtcccgtgtg cagcggcgga ccaccaggca gagcgccaag gggagtgtcc   2220
 ggagatccag catgggaaga gccccctgcc acttccagca aggagcacac agagaggggg   2280
 agcctcctgt taagcatcca agtcccaagt caccggccgg catcggctgc agctctctgt   2340
 gtgtggagac atctcattct ggtgtcttct ttacacaggg tctgcatctg ggggtccact   2400
 ggggaggact cagcctctcc cgcgtcctcc atcccacaca cctgtccctg ggcagccacg   2460
 gggaacagga gcacagggga cagcaggcag agggcagcgc ccgggcgaag gggactttcg   2520
 cccttgcttc atgcagccct ggcacccgca gcaggacctc ggctgatccc aagggggtcc   2580
 acagtggata tggtccttca ggggtgccct tgaaggcagg aaggggacag gactttatac   2640
 tgttcctccc accccttcga gcagtcacca actgcagccc agatgaggtc aacagcatgt   2700
 ctgatggcgt ggtccccagc ctgcctgatg gcgtggtccc cagcctgtct gatggcatgg   2760
 tccccggcct gtctgatggc gtggtcccca gtctgtctga tggcgtggtc cccggcctgt   2820
 ctgatggcgt ggtccccggc ctgtctgatg gcatggtccc cggtctgtct gatggtgtgg   2880
 tccccagcct gtctgatggt gtggtccccg gcctgtctga tggcttggtc cctggtctat   2940
 ttgatggtgt ggtccccagc ctgtctgaag gtgtggtccc cagcctgtct gatggcgtgg   3000
 tccccggcct gtctgatggc ttggtccctg gtctatttga tggtgtggtc cccagcctat   3060
 ctgaagatgg ggagaggagc tga                                           3083



      <210> 578
      <211> 411
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(411)
      <223> n = a,t,c or g


      <400> 578
 cccactactc ggggctccgc tcggcttctt cgcgccgaga tgcctaagaa ggctggtgcg     60
 acgaccaagg gtaaaagcca gagcaaggaa ccagagagac cacttcctcc cttaggtcct    120
 gtggcagttg atcctaaagg atgcgtcacc atagccatcc atgcaaaacc tggctccaaa    180
 caaaatgctg taacagattt gacagcagag gctgtaaatg tagctattgc agcacctcca    240
 tcagagggag aggctaatgc tgagctctgt cggtatcttt ccaaggtcct agaactcagg    300
 aagagtgatg tggnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    360
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn t             411



      <210> 579
      <211> 994
      <212> DNA
      <213> Homo sapiens


      <400> 579
 ttttagtact gttttaggta ttggggatat accaaggaat aaaacaagat tcctggaggg     60
 agaggggaac ggacagcaaa caatagacac aatacgatcg tgaggtatat agttaatgtt    120
 ggtgatgagt gctcctcaaa ggaaacaact aaaaccagac aagggaagtc ggggtgtcag    180
 ggagaatggt ttgtagtatt gatgacaatg gttaaggaag gcctgagttc tgcaaagacc    240
 tcaaggatat gagggactag agtgccctct gctgtggaag agcctgcgca aagatcctga    300
 ggtgggaggg gtcagggagc caactcattt tacggtaagt ggaggtggga tccaggggag    360
 gattctgagc agaggaggga cgtggcccaa tttgggcttt gaaaggatcc tgcttgtctg    420
 tgtgccagca tcctggtggt ggttggggga gtctgcatca atcctgggtg ctgttacctg    480
 aaaaaatagc aggtgttaga cgaaagaaca gatgtctggc ccattgtttc cagtctgttc    540
 ctgtccacag cttcccttta tgctgagccc ctgccacatg catcatcatc ctggccatgt    600
 ggcattgtca cagaccgtct ctcctgctag cctcctaact cagggcctgg gtcttcccca    660
 gcattaagta aatcagtctc aggcagacag ccctttatag gtgtttgggc caggtgcggt    720
 ggctcacgcc tgtaatccca gctctttgtg gggccgaggt ctttgagctc aggagttcaa    780
 gaccagcctg ggcagcatga caaaaccctg tctctaccaa aaatacaaaa attagccacg    840
 catggtggca cacacctgtg gtcccagcta ctcgggaggc tgaggtggga ggatcgctgg    900
 agcctgggaa gttgaggctg cagtgagccg tgatcatgcc actgcattcc agcctgtgtg    960
 atggagagag accctgtctc aaaaaaaaaa aaaa                                994



      <210> 580
      <211> 826
      <212> DNA
      <213> Homo sapiens


      <400> 580
 aggaggagga gtaggaggag gaggcggcgg ccatttgggc taggacagta aaggcaggtg     60
 agggtggggg ccctggctgg ctggaggaga ttgtataaaa gaaaacacgt gacacaagga    120
 ggggagcagg caggtgtttt aggaaaggtc tggtccaggc aggaaggtgg gatgtttatt    180
 ccagagcaaa atggccttcg tccgtctgtt ctaaccgcca tgcccacttc ttccacagaa    240
 ctacaattac aaccagcatg cgtatcccac tgcctatggt gggaagtact cagtcaagac    300
 ccctgcaaag gggggagtct caccttcttc ctcggcttcc cgggtgcaac ctggcctgct    360
 gcagtgggtg aagttttggt aggtgagtgt cagagtgagc cgacccaggc cacatcctgg    420
 cagtggaggc acagtcaccc ggggcagggc caggatcttg gtatatcctc agatctcagt    480
 gggcagcgac atgaagtcag gcaatttctt gcaaccacca ccgaggcccc gaaaagcact    540
 ggtcgtcagg gagctcctcc ccttggcccc cagcctgtgc cagccctggc ccggctgcca    600
 cacctctgtt tcataggctg gggacccagg ctggtttctc ctggtttctt cccactgcac    660
 tgtggtgctt cagtggccac cagcctcgtc acatacacca gcatctttct gtacctcctc    720
 cctttggtga cctgaagtca ctgtgacagt tctccaggaa ggaggagctt cctacttttg    780
 agtttctctg tggaaataaa acatgaatct tgtttcccta aaaaaa                   826



      <210> 581
      <211> 1266
      <212> DNA
      <213> Homo sapiens


      <400> 581
 atgactcgcc agtgccaggc ctcaaaccaa cagctcgggc cccagcccct ggccacaacg     60
 ccacctgacc tgttcctggg ttttcagcag ctgtttggga cctttgctag ctggggccgg    120
 gagccccact gcgggggccc cgatttcccc caacccatcc agaccgttga agatgccctt    180
 aggaagcctt caggacttca gctgattaat tacattcaca cttatcttcc acttcctgca    240
 aaggtactgg atttccctcc caaacctcct caaccaggaa tggatgtgca gggatttgtg    300
 ctttacctca tgagccctcc agcatcccaa ggacatcctg ttcctaagta ccaaatacac    360
 agaacctttc gacctgcacc tccaggaggt gtggcaggcg tgcttgtggg acacccgttt    420
 gacacggtca aggtacggct tcaggtccag agcgtggaga agcctcagta ccgcgggacg    480
 ttgcactgct tcaagtccat catcaagcaa gagagcgtgc tgggcctgta caagggcctg    540
 ggctcgccgc tcatggggct caccttcatc aacgcgctgg tgttcggggt gcagggcaac    600
 accctccggg ccctgggcca cgactcgccc ctcaaccagt tcctggcagg tgcggcggcg    660
 ggcgccatcc agtgcgtcat ctgctgcccc atggagctgg ccaagacgcg gctgcagctg    720
 caggacgcgg gcccagcgcg cacctacaag ggctcgctgg actgcctcgc gcagatctac    780
 gggcacgagg gtctgcgtgg cgtcaaccgg ggcatggtgt ccacgttgct gcgtgagacg    840
 cccagcttcg gcgtctactt cctcacctat gacgctctca cgcgggcgct gggctgcgag    900
 ccgggcgacc gcctgctggt gcccaagctg ctgttggcgg gcggtacgtc aggcatcgtg    960
 tcctggctct ctacctatcc tgtggacgtg gtcaagtcgc ggctgcaggc ggacggactg   1020
 cggggcgccc cgcgctaccg cggcatcctg gactgcgtgc accagagcta ccgcgccgag   1080
 ggctggcgcg tcttcacacg ggggctggcg tccacgctgc tgcgcgcctt ccccgtcaac   1140
 gctgccacct tcgccaccgt cacggtggtg ctcacctacg cgcgcggcga ggaggccggg   1200
 cccgagggcg aggctgtgcc cgccgcccct gcggggcctg ccctggcgca gccctccagc   1260
 ctgtga                                                              1266



      <210> 582
      <211> 1944
      <212> DNA
      <213> Homo sapiens


      <400> 582
 gtgactgagg cgagatcttc caccctcctg ctccagggcc tctaggtggc ctccagagtg     60
 ggctccacag cttgaaggcg gcgtttttcc gcgggtggtc gcagcgtccg cagagtcgga    120
 gaaagctgcg tcagagactg caacagtcag cacacattcc tgtctgatca ggctccctcc    180
 ctcaagtcct ctgcgatagc tctggcgatg cttcaggact ggtgcaggag gatgggtgtg    240
 aacgcagagc gctctctgct catcctggat atccctgacg actgcgagga acatgagttc    300
 caggaggccg tgcgggctgc cctgtcgccc ctgggcaggt accgagtgct catcaaggtc    360
 ttcagaaagg agctcggggc cagggcagcc ttggtggaat tcgctgaggg tttaaaccaa    420
 agcttgattc cccgccaaat agcaggcaaa gggggaccct ggaaagtgat ctccctgccc    480
 caggcccttg atgctgagtt tcaggatata cccagtttcc ctgcacagcc ccaggggcaa    540
 gcagtggcca gaggtgcagg tgaagcagga gctgcaggtg aggcaggatc tgtaggtgag    600
 gcaggaggtg tgaatgagga aagatctgca ggtgaagatg aggcaggagg tataggtgag    660
 gcaggaggtg taggtgaggc aggagcagca ggtgaggcag gagcagcagg tgaggcagga    720
 gcagcaggtg aggcaggagg tgcaggtgag gcaggaggtg caggtgaggc aggaggtgca    780
 ggtgaggaag gaggtacagg tgaggaagga ggtgcaggtg aggcaggagg cgcaggtgag    840
 gaaggaggtg aagatgaggc aggagctgca ggtgaggcag taggtgcagg tgtggtggag    900
 gcctggaccc agtcatggcg ccagaccctg cggcctctgg tgaaaactat ggcctaccgg    960
 gaactgagac ccttttccgg gagggagcag ccaggctgcg tggaagagtc ctttgagagc   1020
 tggttggagg acgccaagga tatgctgcag ctgtggtgcc acgcgtcgga aagggagaga   1080
 aggaggcggc tgctggacag cttggatggc ctggccctgg atatcgtgag cggcctcctg   1140
 gaggaagatc cagacttctc tgcgcaggac tgcctgacgg cgctggggca ggtgtttagg   1200
 agccgggata catggatgac ctcgcggatg aagttcctga cctgcacgca ggggccccag   1260
 gaggggctgt ttgccttcgt ggtgcgcctg gaaggcctgc tgcagaaggc cgtggagaag   1320
 ggggcggtcc acccagccat ggccaaccac ctgcgactgc ggcaggtgct gtctcgggcc   1380
 cgccccagcg aggcactcca ggataccctg aggaggatgc agctggagag gaggccacct   1440
 gacttcctga ggctgctgcg gctcatccgg gacatggagg cgtgggcagc ctccctagca   1500
 aggagccagc agggtgtggc ctgggcagcg gccccagtgg agagtgaaga cccagctgct   1560
 gcccaggcct ccccggccca gggggacgcc agcgaggctg atcccggagc agaagatgct   1620
 gatgaggctg cttccaccac caaagaggcc gccagggttg cccctgccac tggggaagat   1680
 gaaaatgccc ctgcaggcct tgaaggccta ggtcagggaa ggtcccccga cgcccctggg   1740
 ggcctcccag ccaggatggg cagtgcagtc gacatggccc caggaggtcc cagctgggag   1800
 ccagagggcc ttgtccaggt tggaggccag gaggctgagg agcctcccca ggaggggctc   1860
 aagcccatct tagaggagtc agaaaacgag gatgaggatg gggctgggga ggcgggcaag   1920
 cccaagtccc ccccgggcaa atag                                          1944



      <210> 583
      <211> 2394
      <212> DNA
      <213> Homo sapiens


      <400> 583
 acttggaaaa gcaaggagtg tcgggaatgg cgaccaagcg gctcgcgcgg cagcttggat     60
 taattaggag aaagtcaatt gcgccagcaa atggaaatct cggaagaagc aaatccaagc    120
 agttgtttga ctacttaatt gtcattgatt ttgaatcgac atgctggaat gatgggaagc    180
 accaccatag ccaggaaata attgagtttc cagcagtgtt gctgaacaca tcaactggac    240
 agattgactc tgagttccag gcttatgttc aacctcagga acatccaatt ctttcagaat    300
 tttgcatgga attgacaggc ataaagcagg ctcaagttga tgaaggagtc cctctgaaga    360
 tttgcttatc tcagttctgt aaatggattc ataagattca gcaacagaag aacattattt    420
 ttgctactgg gatttcagag ccttctgctt ctgaagtaaa attatgtgca tttgttactt    480
 ggtcagactg ggacttgggg gtttgcctgg agtatgagtg taaaagaaaa cagctgttaa    540
 aacctgtgtt tttaaattct tggattgatc tcagagcaac ttacaagctt ttctatagga    600
 gaaaaccaaa aggactaagt ggtgcttgca ggaagtagga atagaattct caggacgaga    660
 acattctggg ttggacgatt ctcggaatac tgcccttctt gcttggaaaa tgatcagaga    720
 tggttgtgta atgaaaatta caaggtcgtt gaacaagttc ccactaagaa gaatttcagc    780
 attctggcca gaaatttgaa tacaattcaa gttgaagaaa tgtctgcctg taacattagc    840
 atccagggtc ccagcatata taataaggag cctaaaaata taataaatcc tcatgaaaaa    900
 gttcaaatga agtcaatttg tgcaaattct cctataaagg cacaacagga tcaattacaa    960
 gtaaaaaaca atataaaagc aagtcttcac aatgtcaaaa gttccttacc tctttttaat   1020
 actaagtcct ctacttctgt ggggcagttg cagtctccta ccttgaattc acctatctat   1080
 atgcaaaagc aaggaaaaaa tgaacatctt gcatttaata ccaaatctaa ggcttcaaca   1140
 gttggttcag aattggtact tgtttctacc accgttccaa ctgttcatca tgtttctgat   1200
 ttggaaatga gctctactct ggactgttta cctgtgttgg ctgattggga ggatgtggtt   1260
 ttactgccag catctcagcc tgaggaaaac gtagactgta cagttcccat tagtgactca   1320
 gacttagaga tttcatttaa ttctggagaa agattaatgg ttttgaaaga attggaaatg   1380
 tcaagtcatg aaaactttgg agacatagag gaaactcctc aaaaatctga gacttctaag   1440
 tctattgtgt acaagagtcc tcacactact atttataatg taaaagaagc caaagatcca   1500
 ggttcagata tttctgcctt taagttacct gaacacaaat caagtacctt caacagagtt   1560
 aatgccaata tgtctcatcc tttagttttg gggaaacatc ctcttctttc aggtggtacc   1620
 aaaaggaatc catgcagtcc ccaagctttc ccaccagcaa aaaaacaacc cttcactatt   1680
 catgaagaaa agcctacatc atctgattgc tccccagtaa gaagttcttc ctggaggcgt   1740
 ctcccatcta tattaacttc tacagttaac ctacaagagc catggaagag tgggaaaatg   1800
 acacctccat tatgcaagtg tggtcggaga tctaagagac ttgttgtttc taataatgga   1860
 ccgaaccatg gaaaagtctt ctattgttgc cctatcggga aataccaaga aaacagaaaa   1920
 tgttgtggtt atttcaaatg ggaacaaaca cttcaaaagg aaagagccaa cagcatggtt   1980
 ccatctcatt ccacaggggg actcactttt agttctccag aaacaagcca tatttgtgac   2040
 agaaatttaa gtatttccac caaaaattct ttgagactca ggccttcaat gaggaattga   2100
 taacctttca tgtatgaatc ctaattgttc cttgaatttc caaacatgag tattctgata   2160
 acatcttaca ctattttatt tttattttat atattaatgc ttactgcatt taccatactt   2220
 tcttcaggaa ccacaagtgt aatcttttgt aaacagtatt tattagatta catataataa   2280
 gcaacaatag tatatgatcc ttcttttata gttagacctt gaaacaagtc taaactattt   2340
 ttaaattatt tgcacaaaat gtgactaaaa aaaaatccct agtctatttt cagg         2394



      <210> 584
      <211> 1685
      <212> DNA
      <213> Homo sapiens


      <400> 584
 tttcgtggcg tgcggcggag gcgaccataa tgttgttagg ggcatttgtg tctcgtccgc     60
 gggaagaccg gcggagccca taaggccttg gggtggaatt ctgagagctg attcctgcct    120
 tgacttctcc actgttcctg gaggaatccg agaagagcag agcggaggga gccccagaca    180
 cgggccgcgg cagagctcgc ggagcttggc gagtgtttcc tggcctctct ggttggtcag    240
 cacccccagc cagctggccc aggacccctc tacagatgtc caggagagca ggcgttacca    300
 agatgtccga ccccttcctg aagctagtct tcatcaagga cacgacattc cgccccaagc    360
 gcaagttaga gccaggcacc cagcgcttgg agctgcacaa gaaggcgcag gcgtcgctga    420
 acgccgggct ggacctgcgg ctggccgtgc agttgccccc gggcgaggac ctgaacgact    480
 gggtggctgt tcacgtggtg gacttcttta accgcgtcaa cctcatctac ggcaccatca    540
 gcgacggctg cacggagcag tcctgccccg tcatgtcggg gggccccaag tatgagtacc    600
 gctggcagga tgagcataag ttccggaagc ccacggcact ctccgcgccc aggtacatgg    660
 acctgctgat ggactggatc gaggcgcaga tcaacaacga ggacctcttc cccaccaacg    720
 ttggcactcc gtttcccaag aacttcctgc agacggtgcg gaagatcctg tcgcggctgt    780
 tccgcgtgtt cgtgcacgtc tacatccacc actttgaccg catcgcgcag atgggctccg    840
 aggcccacgt gaacacctgc tacaagcact tctactattt cgtcaaggag ttcggcctca    900
 tcgacaccaa ggagctggag ccactggtgc gcgggcttgg ggctgagggc gtgcggttac    960
 gctggcggcc ccggctggag ttgggccccg gggaccctgc tgatgggaca agtggtgagg   1020
 tagctgggag ggatcctgcg ttctcccacg gaacaaatgc cggcgacaga tctgaaaatg   1080
 ctgactctct ggcctcatgg ggtagcctgc tgcccctggt ctcagaaaga aatgaccgcc   1140
 cggatgtgcc actgagacgc cccgcgggtc tcccggtgcc cgaaccgccg ctggggcctc   1200
 ggagacttgg aggaggacgc tctggaacca tcatcccgct tctctccggc ctgagcatct   1260
 cagggagacc aggggccgag ccgctgagca ggtgttggtc ctcaggagct ccaacccgcg   1320
 gactgcagat gccttcctca gtctcgagcc tcagtctccc gtctgggact aaaacgtgaa   1380
 ctctgtaatt ctatgtgtta ctagcaaccg gaaaagccca ctgtgttttt aaaccacttc   1440
 cactttccag gaggctggat ggcttccagg gtcactcctt gccctgggtg gctcccaggc   1500
 tcctggaact tctgcctcca cctcgctggg gagcccccag ggctgctgtg gccacagccc   1560
 tgcctgggcc tgtctctcaa gggcacccag cttgctcggc ctcctacatg tctcccgttg   1620
 gggaggcaag aggctgaggg gcttccgagc ccctgagagc ggacatctcc tcccgcaggc   1680
 cttta                                                               1685



      <210> 585
      <211> 1595
      <212> DNA
      <213> Homo sapiens


      <400> 585
 atgctgcccc tgctcgccgc gctcctggcc gccgcctgcc cgctgccgcc cgtccgcggc     60
 ggggccgcgg acgcgcccgg cctcctcggg gtgccctcca atgcttcagt caacgcgtcc    120
 tccgcggacg agcccatcgc cccgcggctg ctggcctcgg cggcccccgg gccccccgag    180
 cgcccgggcc cggaggaggc ggcggcggcg gcggcgcctg tgcaacatca gcgtgcagcg    240
 gcagatgctg agctcgctgc tcgtgcgctg gggccgcccg cggggcttcc agtgcgacct    300
 actgctcttc tccaccaacg cgcacggccg cgctttcttc gccgccgcct tccaccgcgt    360
 cgggccgccg ctgctcatcg agcacctggg gctggcggcg ggcggcgcgc agcaggacct    420
 gcgcctctgc gtgggctgcg gctgggtgcg cggtcgccgc accggccgcc tccggcccgc    480
 cgccgccccc agcgccgccg ccgccaccgc cggggcgccc accgcgctgc cagcctaccc    540
 cgcggccgag ccgcccgggc cgctgtggct gcagggcgag ccgctgcatt tctgctgcct    600
 agacttcagc ctggaggagc tgcagggcga gccgggctgg cggctgaacc gtaagcccat    660
 tgagtccacg ctggtggcct gcttcatgac cctggtcatc gtggtgtgga gcgtggccgc    720
 cctcatctgg ccggtgccca tcatcgccgg cttcctgccc aacggcatgg aacagcgccg    780
 gaccaccgcc agcaccaccg cagccacccc gccgcaagtg cccgcaggga ccaccgcagc    840
 cgccgccgcc gccgccgctg ccgccgccgc cgcggccgtc acttcggggg tggcgaccaa    900
 gtgacccgct ccgctcctcc ctgtgtccgt cctgtgtccg cgcgcgcggg tgcctttccc    960
 gccggggact cggccggtgt gcttcgtgct gtagttatcg ttagttcctc ttcccgagat   1020
 ggggccgccg agagacccca gcgsctttga aaagcaaggt ttgtgctgcg cttccagttc   1080
 cgaaaagcag atgtttaagc ccttggactg agggtgggat cgcagactcc gcaagacgga   1140
 gaggagggaa atggggccct tttcccctct attgcatccc ccctgcccga ctccttcccc   1200
 gcacccacgg tgccctagat tcatggcaga aaatgaccca aatccctgtg tatttgtttt   1260
 atatatttaa taaactgttt taaaatgaaa gttttagtta aaaaaaatac aaaacaaaaa   1320
 gattaaattg ctattgctgt agtaagagaa gctctttgta tctgaacata gttgmtattt   1380
 gaaatttgtg gttttttaat ttatttaaaa ttggggggag ggcatgggaa ggatttaaca   1440
 ccgatatatt gttaccgctg gaaaatggaa ctttatggaa ccttttccaa gttgatctat   1500
 ccagtgacgt ggcctggtgg gcgtttcttc ttgtacttat gtggtttttt ggcttttaat   1560
 acagacattt tcctccaaaa aaaaaaaaaa aaagg                              1595



      <210> 586
      <211> 1987
      <212> DNA
      <213> Homo sapiens


      <400> 586
 atgagtaagc cagaatggtt gatagtgggg gaggatgatg acgacgctgc ctttgcccct     60
 gtcttgtgtg aaacaactgc ctgtgggttt cctgcagcgc agtggggagt gagaggagaa    120
 acgtcctgcc gtgccacacc cacgccctcc cctgcgaacg cgcacgtgaa cgggagcgcg    180
 gacgcgcccg agaatgcgct tcacctcgca gaagcggcac ctcggctgct gcccggcagc    240
 ggcagcagct gcgtcggcgg cccacacagc agcgagaggc gagaggaggc tgcctcgagg    300
 aggctgcctc gaggatgaag tgcaaaccca accagacgcg gacctacgac cccgaggggt    360
 tcaagaagcg ggcggcgtgc ctgtgcttcc ggagcgaacg cgaggacgag gtcctgttag    420
 tgagtagcag ccggtacccg gaccgctgga tcgtgccggg cgggggcatg gagcccgagg    480
 aggagccggg cggtgcggcg gtccgagagg tgtacgaaga agcgggagtc aaggggaagt    540
 taggccggct cctgggcgtc ttcgaacaga accaggatcg caagcacaga acgtacgtgt    600
 atgtactgac tgtcacggag ctgctggagg attgggaaga ttcggttagc attgggagga    660
 agcgagagtg gttcaaagtc gaaggaatgc aatccaaggt cctcaagtgc aacaagccgg    720
 tgaaggcgga ttatctgaag aacttaaacc tgggcggttt ccccaccaat tggaaattca    780
 tgggcccatt cttggcagat agcgattcct aatggacagc caagatgttc agtattgtgc    840
 tgaaagaaac attgatgtga acccagtgat cagtggaatt gtcaagtaca ggtgagcact    900
 tctgtgttcc caagaagaca gctcatctgg tttcttcctg catcttggga cactccttcc    960
 ctgtctatac cactgactct tgctctggtt gttgtactct tatacgtgaa tagactctta   1020
 attcagcacc tatagccttt tgttgtgctt ttttgatgtg tctgccttca ttagactatg   1080
 atgtctttga gagcaaagac tatttttcct tactctttgc atattctgca tctgagacac   1140
 tacttgaaat atggttggca tcactgaagg ttctttgatt caattaatat tttgtaatca   1200
 ccgtgtggca aaacattccc cttccaatct ggtgctagta gagtatatgc tatctaggca   1260
 ccatgtgtgt ggcttttgtg tatcaggtgt ttcagaaata tttcaagacc agtgtaagat   1320
 gtttgaggac aagaattatt actcctattt ctatgtcata ccacacagta gctgcacagt   1380
 tttaagatta tgccatcacc tagggtaatg ttttgtagaa tcagtccttc gtgtaacaac   1440
 tctagtgttt ttgtactgtt gatgatttgc ttaaatttta ttcaaaaact atcacttgct   1500
 ataaaggtaa ttgtaaaaat aaatacagtg gacgcaaaat aatgttgtga gtttttataa   1560
 aaataaattt taaaatgata tataagacat ttttttgcaa tgccctgccc taaccacttc   1620
 ttacatgtca tcttaacatc tctttgagga aacactgttt cctcatttta cagatttaac   1680
 atactgtatt atttgatgcc agagccaaca ggtaatatca taggcagttt ccaaacttaa   1740
 ttatgccatt tagtttgtct agatttcttt tgcctctctc actgatccat ttggctgtag   1800
 ttttcatccc ttttccagta cacacagcta gctcctcatc ctacctgggg ttctgcatat   1860
 gaggaatgca gaggggctga ggggggggca aaattgttgt tcatttagga aaagggcctt   1920
 tagggaaaga gggctgctat tagaggggaa cacaaagtga aggttttttt aaaaaagagg   1980
 acttgca                                                             1987



      <210> 587
      <211> 2707
      <212> DNA
      <213> Homo sapiens


      <400> 587
 cggacgcgta ggggccgaga tcccgggcac gctggttctg gtgagcgcgg cctccgcggc     60
 tccttggccc caggatgccc tctctcgtgg ggaaaggagg gtcgggaaag gccgagcgta    120
 agtccacctt ctccaatccc tgcctgctgg gagaggacga tctcttgaga aaggaaagac    180
 ttctgtgctc ccgagaactt cctatcaggt cctggctgca gggaaacaag ctgggctttt    240
 tataattaag gttggaagaa gtcaccacag gcagcagaac tccatcttga gatgaaataa    300
 catctacctg gacctctgtc agaatttcaa ggcacacact gggctgactc tggcgccatg    360
 atgttgcctt atccttcagc actgggagat caatactggg aagagatttt gcttcccaag    420
 aatggggaaa atgtagagac tatgaagaaa ttgacccaaa atcataaagc gaaaggcttg    480
 ccttctaatg atactgacct cccccaaaaa aagggaggga agggcccaaa tagtggtacc    540
 agttacattc agggatgtga ctgtgatctt cacagaagca gaatggaaga gactgagtcc    600
 agagcagagg aatctataca aagaagtgat gctggagaat tacaggaatc ttctctcatt    660
 ggaaaacttt cattcttcag cagaaccaaa gccagaaatc tacacttgtt cctcctgcct    720
 tctggccttc tcctgtcagc agttcctcag tcaacatgta cttcagatct tcctgggctt    780
 atgtgcagaa aatcacttcc atccagggaa ttctagccca gggcattgga aacagcaggg    840
 gcagcagtat tcccatgtaa gctgttggtt tgaaaatgca gaaggtcagg agagaggagg    900
 tggctccaaa ccctggtctg caaggacaga ggagagagaa acctcaaggg cattccccag    960
 cccactccaa agacagtcag caagtcctag aaaaggcaac atggtggtag aaacagagcc   1020
 cagctcagcc caaagaccaa accctgtgca gctagacaaa ggcttgaagg aattagaaac   1080
 cttgagattt ggagcaatca actgtagaga gtatgaaccg gaccataacc tggaatcaaa   1140
 ctttattaca aacccgagga ccctcttagg gaagaagccc tacatttgca gtgattgtgg   1200
 gcgaagcttt aaagatagat caaccctcat cagacaccat cgtatacact cgatggagaa   1260
 gccttatgtg tgcagtgagt gcgggcgagg ttttagccag aagtccaacc tcagcagaca   1320
 ccagagaaca cattcagaag agaagcctta tttgtgcagg gagtgtgggc aaagctttag   1380
 aagtaagtcc atcctcaata gacatcagtg gactcactca gaggagaagc cctatgtttg   1440
 cagcgagtgt gggcgaggct ttagcgagaa gtcatccttc atcagacacc agaggacaca   1500
 ctccggtgag aaaccctatg tgtgcctgga gtgtggacga agcttttgtg ataagtcaac   1560
 cctcagaaaa caccagagga tacactcagg ggagaagcct tatgtttgca gggagtgtgg   1620
 gcgaggcttt agccagaact cagatctcat caaacaccag aggacacact tggatgagaa   1680
 gccttatgtt tgcagggagt gtgggcgagg cttttgtgac aagtcaaccc tcatcataca   1740
 cgagcggacg cactctggag agaagcctta tgtgtgtggt gagtgtggcc gaggctttag   1800
 tcggaaatca ctcctccttg tccaccagag gacacactca ggggagaagc attatgtctg   1860
 cagggagtgt aggcgaggtt ttagccagaa gtcaaatctc atcagacacc agaggacgca   1920
 ctcaaatgag aagccttata tttgcaggga atgtgggcga ggcttttgtg acaagtcaac   1980
 cctcattgta catgagagga cacactcagg agagaagcct tacgtgtgca gatgtatggg   2040
 caaagctttt gtgatcacac accacaggga gaatctgcat gtggggacac tgtggagctc   2100
 tgcccagatg accttttcag gggtaacacc ccagctgctt gagagaacag tgttgctgct   2160
 ggcagagatg cattccagag atgcactccg ctctggaact cactctcagc cacagggagc   2220
 tgcatgcacc acaggggcaa tgcacctttg caggggtacc ttctggcccc aacccttgac   2280
 tcaacgggga caactccaga aggtcattcc agatccagag atccccatcg aactgaagga   2340
 tcactgggtt gcagacacat tgcaggtccc acccataaat ctcatcataa tggcaattga   2400
 atttcaacat gaattttgga ggagacattc acaccatagc atcaattacg cagtggctcc   2460
 tcagtcaggt ctgatgaggg aaaaggatgt gcatgtctgg gagtgtgggc ccccaccctt   2520
 tgccagaact gcccctataa caccaacttc tgatcagaat tggaggccac tgagggaaaa   2580
 gaagggtcac tatcaggacc tttccactcc atcccagaag gaaacagaat tgaaacgtac   2640
 tagagtttct ctcagaagaa agagagatgc aaattctcca ctccaggact atggctttgg   2700
 tgcctaa                                                             2707



      <210> 588
      <211> 411
      <212> DNA
      <213> Homo sapiens


      <400> 588
 tcacctggaa ggcagatcta tttgagaatc tggactgtct cctatcatga ttcccgggaa     60
 atatcgctct gtttctggcc gggctgcgaa caacgtgaac tgcgggcttc atctggttat    120
 tcaaacatca tcgcttcctg aaaaaaacaa aacaaaagct gaccgtatgt cctatcatca    180
 atggggaaga ccaccttcgt ttgttgaact ttcaacacaa ttttataact cggatacaaa    240
 atatttctaa tctacagaag ttaatatcgt tggatttata tgataaccag attgaagaaa    300
 ttagtgggct ttcgactctg agatgtcttc gtgtccttct ggtggggaaa aaccgaatcc    360
 agaaaaacct tcatctggag aatttaaaaa agcctaaaag gccttggatc t             411



      <210> 589
      <211> 423
      <212> DNA
      <213> Homo sapiens


      <400> 589
 tttcgtgctc gggagacatg gcgggcgtta aagctctcgt ggcattatcc ttcagtgggg     60
 ctattggact gacttttctt atgctgggat gtgccttaga ggattatggg taagttatca    120
 tttcaaaaag aactattcct ctttctgtgt ctttgtcact attagtatgg gtgttagaga    180
 gttcggtcaa tttagcacca agttctaacc agtgagttag tggagcccag tttatgaaca    240
 cagtcccttt gtgggtcagg tgtacttttg cagagggctc tgttaaaaat tgatgcattc    300
 atctccatac agcatttgtt taacacctac tctggactag ctggggacac gcaaacgaag    360
 agagagtcct gtcctcaaag aggaggtaaa gttctagttg tgagtgagag acaggcaaac    420
 ggc                                                                  423



      <210> 590
      <211> 3707
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(3707)
      <223> n = a,t,c or g


      <400> 590
 atggcttctt caaagctccg agaacccgtg gatgaagttt ttgacctgga cttggctgtg     60
 ccagagacgg ccagactgga cagcagttta cacaaggccc gggcccaact gttggccaag    120
 ggccggagac accggccatc ccgctccagg cttcgggaca gtgccagctc cgcggaggat    180
 ggtgaaggct cggatgggcc cggaggcaag gtgaccgatg gctgcgggag ccccctgcac    240
 cggctgcgct cgcctttgca ctcaggcccg gggtccccgg ccgggggctc tttctgcctg    300
 gatcctccgg ggttgcggcg cagcctggac gaggacgagc cgccgccctc gccgctcaca    360
 cgctaccggc ccctgcacaa cgctgcgtcg cacgagggcc tggccgccgc ctcctgctct    420
 ccgccgcgct ccgcgccctc ctccgacagc tcccccagct tcgtgcgccg ccacccgcgc    480
 gcagagccgc acagcgaaga tgacagccgt gacgccagtc ctcctgagcc cgccagcccc    540
 accatcggcc tcgataagaa gactcgccga aagttcctgg acctgggggt caccctgcgc    600
 cgagcatcca cgggcaagag ccggaaggag aaaggcagca accgactgtc catgggcagc    660
 agggagtcag tggaggggtc cggcaggtca gggggctccc cgttcctgcc tttttcctgg    720
 ttcacggaca gcggcaaggg ctcagcatcc tcgggtagca ccacctcccc cacctgctcc    780
 cctaaacacg agggcttcag ccctaagaag tcagcttccc aggcccagct cctggctcat    840
 gcacaggagg cactgagcaa ctcctggtgc ctagtccagg acttcggctc cacccagata    900
 gggatggaat ccactctgag tgatgactcc acgcccccca gcagcagccc caagatcccc    960
 agtgggccct ggcaggaggc caaatgttct tacccctacc acacgctgtc tcagtcttca   1020
 gatgagttcc tggatgaacc cctcccccct gtccaccact ggaccagcca gcaggtgggc   1080
 cagtggctgc agagcctcaa cctggaacag tatgctgctg agtttgctgc acggcaggta   1140
 gacgggccgc agctgctgca gctggacgga agcaaactaa agagcctggg gctcagcaac   1200
 tctcatgacc gggcactggt gaagcgcaag ttgaaggaga tggcagcagc tgccgagaag   1260
 gagcgcaagg cccaggagaa ggctgcgcgg cagcgggaga agctccggcg ccgagagcag   1320
 gaggccaaga agagctaggg gagggtgcac aggcgctggc acccggcagg ggcagccact   1380
 ggctccgcgg gcacaggcct caccagggag gctggacctg ggcgctgcac ttgggctagc   1440
 ctggtcccac gctctcaggg gggacatgct ctctcttacc ctgtcacttg gtctagaccc   1500
 agagacccca gaaagggaga ccccagggag agggcctagt aataaatcct attttgagga   1560
 cttgtttggc acagagttcc tgggggagga gcagatgaag gggagagggc agagaggcca   1620
 gggctgaggc aagtctggga ggctgggtca ggctgtccca ttgccctcag gccatcgtgg   1680
 ggctggggtg gaggggagct aggaggcctg cctgcctgct tgcctgccag aggccctgag   1740
 gccgggcccc cagggctcag agctgggctg ggcatttcag caggagccca tgtgggagcg   1800
 gctcctctcc actcttccag ggggctgtgt ggtgggagag ctctgtcctg ctcccccaag   1860
 aggccagtgg gcgctgcagc aagtcgcact cagggtagac tcccagccaa actcctcaac   1920
 aggagcgcag agaaagcagc ctggggcgag tgcagtcttt gccaggactc aagaggggag   1980
 gatgaacatc cccttctccc tctcccctcc tctgtcctgt gggtcccagg gggcgagatg   2040
 acaccacaca ggtctgcctc tcagggccca ttcaagacct ggtctttgac ccattctcca   2100
 agccaggact cccttcactt cctgctgctt cctcagaggg cacctaagtc ctctttggga   2160
 gctgagcaaa caggaactga tagggacaga ggacaccact tccaccagcc aaggcctagg   2220
 agctgctgac ctggtcagcc ctcaccccag ccaggcagag aggcaaaacc tgggggtccc   2280
 cggcagctac gagattggaa aggttcatca gccctccccc atctgcccca ggcattgtca   2340
 gggaatcagt gggctcagaa ctggcaggcg gtgcaagctc tgcttccctg ggccacactg   2400
 agggctgggg ccagctccct ggatgggggt ggagtttacc agcagcctgg ggacagcatg   2460
 tgtccttttt aggaaatgtc cttggaggaa gtgttcatgt gtggcgctgg tcagcagcta   2520
 gtcccgcttc caggacactg gtcagagtta ccgatgaggc ctgggggctc ccgcttggaa   2580
 acccctccag ctcctcccat ctgcccagac agagcggcag atggcaccaa tgcatgctgg   2640
 ctccctcatt cctgcccagg ggctgtggct tacggccagc accctgtacc tgggactcag   2700
 cccttatccc ccctctgcta tctgtgctgg gagaggggct tcggagggaa acagatatga   2760
 ggacactggc accatctggg cctggtggca gggccatggg aggttggaag gcacccacat   2820
 ccttaaagcc atcagtagct ctagtgggtg cccaccttgc atgtgaaggg gaggcagttc   2880
 ttcaatttat ttcaataaat ccttatgatg tgccagtgac cagaatttct gtctgctcca   2940
 gttgttgggt tggccggact ctgctgggcc ctgagtatgg tgggacaaca ggtctgtcac   3000
 caggtgctgg gccatccggc gttctgaaca gatggctttg ccaggtgttt tactcacagt   3060
 cctgagctgg gccggacgtc cccggtgcgt catgtgggtg gtcacagggc accgcagtgt   3120
 gcgtgtgtac gtgcgcacgt gtgggtcccc tcccccaggg atgcagccag gccagtctca   3180
 ttcagtctcc tctttactgt gggtgtgggt gtcactggtc actgccacag ccactgggag   3240
 ggacacacag ctttaacccc tgtgtgctta ggggaagggt gggggcattc agggttataa   3300
 aactaactat atacacagaa ggtcctaggg agaaagccac cctgagcaca catgtctggg   3360
 cacagtgggg gcctgggggc tgaagctcag gcaggatgga ctaggcttgt ggaggagcgg   3420
 gtgggcatga gcatgtgagg acatgctggg agggctcagg aggtggcaca gacattgcca   3480
 aggccactgc agggccttcg agcagcttgg ctgggatggg caagcttctt cggttttaac   3540
 aaggttcttt ccacttttag gagtttnggg ccctgtgaga gccacccctt ccgccaccga   3600
 ccttcaagcc ctgagccgaa gggagaggct gcaggaccag cctcattccc cactcacggg   3660
 tgtaactcct ttccccactc agtccccagg tctagagggc acccacc                 3707



      <210> 591
      <211> 396
      <212> DNA
      <213> Homo sapiens


      <400> 591
 atgactggca gtctgtttag gcgaggccca gaaacagaaa gcaagtcttg tgaaagtcag     60
 aatctgggag ctttgcagat gcgtcaagat gtgacccagc acattcacag gtctggtggc    120
 tacgaggaga gaccacttct gcttgagaag aacagaggga agaataaagg ggactccgtc    180
 ttgagcttag gtaccagctt agccacagtg ggaaagagca ccaagccagc tctttgggtc    240
 cctgattcca gtccttggct cttggatggc atctctggac ctattctagg ccagagagga    300
 gcccactgcc ctgaagggcc tgaatccttg tgccagcagc ccacaaagag gcatgccaca    360
 ggtgagcctc atcatccttc tgatggcagc agttaa                              396



      <210> 592
      <211> 1181
      <212> DNA
      <213> Homo sapiens


      <400> 592
 ttctggtcac ggttagccag gctcgccggg aaagttgcca gtaactggct gaacacaccg     60
 ttgatgatct gcgctacctg ctgtacctgc ggcttttcgt cgtactgttc cggcatgttg    120
 ttggcgatca gacgcatctg ctcacggtca aagttgacca tctgtgcggc gatgtttttc    180
 atagatccac cccgtaaatc cagtctgtgt ttgtcaggtc gagttttggt ttgctggctg    240
 tcacgcctgc ctgttgcttg ttacggttga tttcgagttg ggtccactta tcgcggagtt    300
 tggccgggct cagcacgtta ccggaccaga agttgtcctg gcatgcccag cggaacagca    360
 cacacatgtc gcggtggtta cgtccgtcac gttcacgcat caggcggata tcgttagccc    420
 acccagcaaa attcggtttt ctggctgatg gtgcgatagt cttcaccatg tcaaacatcc    480
 actctgcggc ggtcaggtct tctgctgtcc cccacttgct gccgctctga attgcagcat    540
 ccggtttcac cacagaaagg tcgttttctg gctggtcaga ggattcgcca gaattctctg    600
 acgaataatc ttttcttttt tcttttgtaa tagtgtcttt tgtgtccccc tgttttgagg    660
 gatagcaatc ccccaatttg agggatgttt tatccctcgt tttaggggat tttccctcgt    720
 tttgagggat gcaccattct gagatgtttt tatttggtcc aaacatgccg ccttgctgct    780
 tgataatatt cattctgacg agttctaact tggcttcatt gcaccgtttg acaggtaact    840
 ttgtaatctc gctaagttga gaatcggtga ttctgtccat tggtttattc cacccatagg    900
 ttttacgcag aatggcaagc agcactttaa actgtcgctt ggtcagatct gcgcccgaat    960
 aagcctcaag cagcatattt gatagtctgg cgtaaccatc atcgagatct gccacattac   1020
 gctcctgtcc ggcaaagtta cctctgctga tctgcgactt atcaacgccc acagcttccg   1080
 ctgtcttctc agttccaagc attgcgattt tgttaagcaa cgcactctcg attcgtagag   1140
 cctcgttgcg tttgtttgca cgaaccatat gtaagtattt c                       1181



      <210> 593
      <211> 2193
      <212> DNA
      <213> Homo sapiens


      <400> 593
 atgcctgaac ctccccccgc cccaggctcc tgcgcagccc gagcctccaa gacgagcgcc     60
 gctcctggct ccacggcgcc cagtcccatc caccgttcaa gggctgagga gcgtgggacc    120
 acggcgcgga actggcaggc agctccaact gcagccccgg tgcgggatcc actgggtgaa    180
 gccagctggg ctcctgagtc tgctaatcta gtgggaatct ggagaacttt tgtgtctagc    240
 tcagggattg taaatgcacc aatcagcacc ctgtcaaaac ggaccaatca gctctctgta    300
 aaacagacca atcggctctc tgtaaaatgg accaatcagc aggatgtggc ccgtggctcg    360
 gcgacttaca gggagggaga acatggctgc tggcttttag cacctggtgg gtttcgcgcc    420
 ttgcaactcg acaactgccg ggacggagtc tgcgtgcgcg accccctgcg gcaggtgctg    480
 ggcgaggcgc ctcccctgca actagcctgc cgcttccctc ccggcacccc cgccgccagc    540
 cccgagcgcg gacctggagc ggagaagaga gtgtgcggaa aggatgtatc agaagtaacc    600
 cactgcacac atgatctctt acatgctaca ttagaagact cctgggatgt tagcagccag    660
 ttagacaggc aacaggaaaa ctggaagaga catctgggat cagaggcatc cacccagaag    720
 aaaataatta caccacaaga aaattttgag caaaataaat ttggtgaaaa ttctagattg    780
 aacaccaatt tggttacaca actgaacatt cctgcaagaa taaggcctag tgaatgtgag    840
 acccttggaa gcaatttggg acataatgca gacttactta atgagaataa tattcttgca    900
 aaaaagaaac cctataagtg tgataaatgt agaaaagcct ttattcatag atcatcgctt    960
 actaaacatg agaaaacaca taaaggagag ggagctttcc ctaatggaac agatcaagga   1020
 atttatcctg gaaagaaaca ccatgaatgt accgactgtg ggaaaacctt tctctggaag   1080
 acacagctta ctgagcatca gagaattcac actggggaga aaccctttga atgcaatgta   1140
 tgtggaaagg ccttcaggca tagctcatct cttggtcagc atgagaatgc tcataccgga   1200
 gagaaaccct atcagtgtag tctctgtggg aaagccttcc agcgcagctc ctcccttgtt   1260
 caacaccagc gaattcacac tggagagaaa ccctatcgat gtaatctatg tgggaggtcc   1320
 tttaggcatg gcacatccct cactcaacac gaggtcacac acagtggaga gaagcccttc   1380
 cagtgtaagg aatgtgggaa agcctttagt cgatgttctt cccttgtcca acatgagagg   1440
 actcatactg gagagaaacc ttttgaatgt agcatatgtg ggagggcttt tggtcagagc   1500
 ccatcccttt ataaacatat gaggattcat aagagaggca aaccttacca aagcagtaac   1560
 tacagcatag atttcaagca cagcacatct ctcactcaag atgaaagcac tcttaccgaa   1620
 gtgaaatcct accattgtaa tgactgtggg gaagacttta gtcacattac agactttact   1680
 gaccatcaga ggatccatac tgcagagaac ccctatgatt gtgagcaggc ttttagtcag   1740
 caagctattt ctcatcctgg agagaaaccc tatcaatgta atgtatgtgg gaaagctttc   1800
 aaaaggagta caagtttcat agagcatcac agaattcata ctggagagaa accctatgaa   1860
 tgtaatgagt gtggagaagc ctttagtcga cgctcatcgc ttactcaaca tgagagaacc   1920
 cacactggag agaaacccta tgaatgtatt gactgtggga aagcctttag tcaaagttca   1980
 tctctcattc agcatgagag aactcatact ggagagaagc cctatgaatg taatgaatgt   2040
 gggagagcct tccgaaaaaa aaccaacctg catgatcatc agagaattca tactggagaa   2100
 aaaccctatt cttgtaagga atgtgggaaa aacttcagcc gaagttcagc tcttactaaa   2160
 caccagagaa ttcatactcg aaataaactc tag                                2193



      <210> 594
      <211> 834
      <212> DNA
      <213> Homo sapiens


      <400> 594
 atgcctatct tgttcaccac tgtatcctca gcacttagtg gggcccagca tatagcagat     60
 gctcagtgtg acagaaaagg gcaccgcact acaattcagg ggtcaagggt caacctggtc    120
 cagccctctg tgggtcccaa ggtggaggag acgcagtgct ggggtccagg ccgagggatg    180
 cctggcgcgc cggaagcacc tagagagcgg cgcgtgcgca gcgggagtcg aagcggagat    240
 cccggggtcg cgcgagagcc gcaagcggag ttggtgggcg ctatgctatc acccgaggca    300
 gagcgagtgc tgcggtacct tgtagaagtg gaggagctcg ccgaggaggt gctggcggac    360
 aagcggcaga ttgtggacct ggacactaaa aggaatcaga atcgagaggg cctgagggcc    420
 ctgcagaagg atctcagcct ctctgatgag gaaaacaacg taaaatgcgt aattgaaaat    480
 tgtaagaaag ccagagatgg aattggactt ggggtgggtg ttgagaatat atatccagaa    540
 gaatgggaca ctttagatga ggccaagtgg ctgtggcagt ggaagcaaat ggggaaagat    600
 gtgatggttt gcttcgggaa catgtttatc aagatgcctc accctgagac aaaggaaatg    660
 attgaaaaag atcaagatca tctggataaa gaaatagaaa aactgcggaa gcaacttaaa    720
 gtgaaggtca accgcctttt tgaggcccaa ggcaaaccgg agctgaaggg ttttaacttg    780
 aaccccctca accaggatga gcttaaagct ctcaaggtca tcttgaaagg atga          834



      <210> 595
      <211> 506
      <212> DNA
      <213> Homo sapiens


      <400> 595
 ctgaaagacg tcattactct acggaggcat gtggaaacaa aagttagagc taaaatccgt     60
 aagaggaagg tgacaacgaa aatcaaccgt catgacaaaa tcaatggaaa gaggaagacc    120
 gccagaaaac agaaaatgtt tcaacgtgcg caagagttgc ggcggcgggc agaggactac    180
 cacaaatgca aaatcccccc ttctgcaaga aagcctcttt gcaactgggt aagtttgttt    240
 gttttccttg cttttgaaca tagtctgcca ggtcaggaca tggatacatt tttctcccta    300
 cagctctgtg ctcaagccct gcagagggag atggcagaga ggaaggctgc ctacagcatc    360
 acagtcccat ccctgttggt aaccgtgttg tgcaaaaaca ccttcatccc cacccagtgg    420
 gcccctgatc taaattcaaa gtgtcagagg ttccatattt gtaatagcaa atgggccctg    480
 actgtaaatt agtgaagagt gaatgt                                         506



      <210> 596
      <211> 506
      <212> DNA
      <213> Homo sapiens


      <400> 596
 ctgaaagacg tcattactct acggaggcat gtggaaacaa aagttagagc taaaatccgt     60
 aagaggaagg tgacaacgaa aatcaaccgt catgacaaaa tcaatggaaa gaggaagacc    120
 gccagaaaac agaaaatgtt tcaacgtgcg caagagttgc ggcggcgggc agaggactac    180
 cacaaatgca aaatcccccc ttctgcaaga aagcctcttt gcaactgggt aagtttgttt    240
 gttttccttg cttttgaaca tagtctgcca ggtcaggaca tggatacatt tttctcccta    300
 cagctctgtg ctcaagccct gcagagggag atggcagaga ggaaggctgc ctacagcatc    360
 acagtcccat ccctgttggt aaccgtgttg tgcaaaaaca ccttcatccc cacccagtgg    420
 gcccctgatc taaattcaaa gtgtcagagg ttccatattt gtaatagcaa atgggccctg    480
 actgtaaatt agtgaagagt gaatgt                                         506



      <210> 597
      <211> 506
      <212> DNA
      <213> Homo sapiens


      <400> 597
 ctgaaagacg tcattactct acggaggcat gtggaaacaa aagttagagc taaaatccgt     60
 aagaggaagg tgacaacgaa aatcaaccgt catgacaaaa tcaatggaaa gaggaagacc    120
 gccagaaaac agaaaatgtt tcaacgtgcg caagagttgc ggcggcgggc agaggactac    180
 cacaaatgca aaatcccccc ttctgcaaga aagcctcttt gcaactgggt aagtttgttt    240
 gttttccttg cttttgaaca tagtctgcca ggtcaggaca tggatacatt tttctcccta    300
 cagctctgtg ctcaagccct gcagagggag atggcagaga ggaaggctgc ctacagcatc    360
 acagtcccat ccctgttggt aaccgtgttg tgcaaaaaca ccttcatccc cacccagtgg    420
 gcccctgatc taaattcaaa gtgtcagagg ttccatattt gtaatagcaa atgggccctg    480
 actgtaaatt agtgaagagt gaatgt                                         506



      <210> 598
      <211> 506
      <212> DNA
      <213> Homo sapiens


      <400> 598
 ctgaaagacg tcattactct acggaggcat gtggaaacaa aagttagagc taaaatccgt     60
 aagaggaagg tgacaacgaa aatcaaccgt catgacaaaa tcaatggaaa gaggaagacc    120
 gccagaaaac agaaaatgtt tcaacgtgcg caagagttgc ggcggcgggc agaggactac    180
 cacaaatgca aaatcccccc ttctgcaaga aagcctcttt gcaactgggt aagtttgttt    240
 gttttccttg cttttgaaca tagtctgcca ggtcaggaca tggatacatt tttctcccta    300
 cagctctgtg ctcaagccct gcagagggag atggcagaga ggaaggctgc ctacagcatc    360
 acagtcccat ccctgttggt aaccgtgttg tgcaaaaaca ccttcatccc cacccagtgg    420
 gcccctgatc taaattcaaa gtgtcagagg ttccatattt gtaatagcaa atgggccctg    480
 actgtaaatt agtgaagagt gaatgt                                         506



      <210> 599
      <211> 3859
      <212> DNA
      <213> Homo sapiens


      <400> 599
 atggtgggag aactccgcta cagggaattc agggtgcccc tggggcccgg cttacatgcc     60
 tatcctgatg agctgatccg ccagcgcgtg ggccatgatg ggcatcctga gtaccagatc    120
 cgttggctca tcctgcggcg tggcgatgag ggggacgggg gctctggcca agtggactgc    180
 aaggctgagc acatcctgct gtggatgtcc aaggatgaga tctatgccaa ctgccacaag    240
 atgctgggcg aggatggcca ggtcatcggg ccctcccagg agtctgcagg ggaggttggg    300
 gccctggaca aatctgtgct ggaggagatg gaaaccgacg tgaagtccct cattcagaga    360
 gcccttcggc agctggagga gtgtgtgggc actatccctc ctgctcctct acttcacact    420
 gtccacgtgc tcagcgccta tgccagcatt gagcccctca ctggagtatt caaggaccca    480
 agggtcctgg acttgctcat gcacatgttg agtagtcctg attatcagat tcgctggagt    540
 gcaggccgga tgatacaagc cctgtcctcc catgacgctg ggacccggac tcagatcctt    600
 ctgtcactga gccaacaaga agccattgag aaacacctgg attttgacag ccgctgtgct    660
 ctgctagcac tgtttgcaca ggccacgctc tctgaacacc ccatgtcttt cgagggcatt    720
 cagctaccac aggtcccagg aagggtgctc ttctccctgg tgaagcggta tttgcatgtc    780
 acctcgctcc tggatcagct gaacgacagt gctgcggagc caggagccca gaacacctct    840
 gctcctgagg agttgagtgg ggagaggggt caactggagc tggagttcag tatggccatg    900
 ggcaccctga tctcggagct ggtgcaagcc atgcgctggg accaggcctc agacagacca    960
 aggagctcag cacggtcccc cggttccatc ttccagcctc agctggcaga tgtgagccca   1020
 gggctccccg ctgcccaggc tcagccctcc ttcaggaggt caagacgttt tcgccctcgt   1080
 tctgagttcg caagtggcaa tacctatgct ttgtatgtgc gggacacact gcagccgggg   1140
 atgcgagtgc ggatgctgga tgattatgag gagatcagtg ccggggatga gggcgagttt   1200
 cggcagagca acaacggtgt gcctcctgtg caggtatttt gggagtcaac aggccgcacc   1260
 tattgggtgc actggcacat gctggagatc ttgggctttg aggaagacat tgaggacatg   1320
 gttgaggctg atgagtacca aggggcagtg gccagtagag tcctgggtag agccctgcct   1380
 gcctggcgct ggaggcccat gacagaactc tatgctgtgc cttatgtgct gcctgaggat   1440
 gaggacactg aggagtgtga acacctgacc ctggctgagt ggtgggaact cctcttcttc   1500
 atcaagaagc tggatggacc tgaccatcag gaggttctcc agatcctcca ggagaaccta   1560
 gatggggaga ttctggatga tgagatccta gctgaactgg ccgtgcccat agaattggcc   1620
 caggacttgt tgctgactct gccacagcga ctcaatgaca gtgccctcag ggacctgatc   1680
 aactgccatg tctacaagaa gtatgggcct gaagccctag cagggaacca agcctaccca   1740
 tcccttctag aagcccaaga agatgtcctc ctgctagacg cgcaggccca ggctaaggac   1800
 tcagaagatg cagccaaagt ggaagcaaaa gaacccccat ctcagagtcc caacactccc   1860
 ctgcagcgtc tggtggaggg ttatggtcca gctgggaaaa tcctcctgga tctagagcaa   1920
 gccctcagct cagaggggac ccaggagaac aaggtcaagc cactcctgct gcagctgcag   1980
 cggcagccgc agcccttcct ggcactgatg cagagcctgg acactccgga gactaacagg   2040
 accctgcacc tgactgtgct gagaatcctg aagcagctgg tggacttccc cgaggcactg   2100
 ctgctcccct ggcacgaggc cgtggatgcc tgcatggcct gcctgcggtc cccaaacact   2160
 gatcgagagc acccagtaca cagagtacac agtggtacct gctactgcag tgcccctgtg   2220
 gccttcgccc tgtttcattc atctcctccc ttatgtcccc acccaggtgc tccaggaact   2280
 gatttcttcc tgcaccgcct gacctcagtg agcagggact atgccgtggt gctgaatcag   2340
 ctgggagcaa gagacgctat ctccaaggcc ctggaaaagc acctgggaaa gctggagctg   2400
 gctcaggagc tgcgggacat ggtgttcaag tgtgagaagc atgcccacct ctaccgcaaa   2460
 ctcatcacca acatcctggg aggctgcatc cagatggtgc tgggccagat cgaagaccac   2520
 agacgaaccc accaacccat caacatccct ttctttgatg tgttcctcag atacctgtgc   2580
 cagggctcca gtgtggaagt gaaggaggac aagtgctggg agaaggtgga ggtgtcctcc   2640
 aacccgcacc gggccagcaa gctgacggac cacaacccca agacctattg ggagtccaac   2700
 ggcagcgccg gctcccacta catcaccctg cacatgcgcc ggggcatcct catcaggcaa   2760
 ctgactctgc ttgtggctag tgaggactcg agttacatgc cggcccgagt ggtggtgtgc   2820
 gggggtgata gcactagctc tcttcacacg gaactcaact cggtgaatgt gatgccctct   2880
 gccagccggg tgatcctcct ggagaacctg acccgcttct ggcccatcat ccagatccgc   2940
 ataaagcgct gccagcaggg tggcattgat acgcgcattc gggggttaga gatcctaggc   3000
 cccaagccca cgttctggcc agtgttccgg gagcagctct gtcgtcacac acgcctcttc   3060
 tacatggttc gggcacaggc ctggagccag gacatggcag aggaccgcag gagcctcctg   3120
 cacctgagtt ctagactcaa cggtgctctg cgccaggagc agaattttgc tgaccgcttc   3180
 ctccctgatg acgaggctgc ccaagctctg ggcaagacct gctgggaggc cctggtcagc   3240
 cccgtggtgc agaacatcac ctcccctgat gaggatggca ttagccccct gggttggctg   3300
 ctggaccagt acctggagtg tcaggaagct gtcttcaacc cccagagccg cggcccagct   3360
 ttcttctcgc gggtgcgccg tctcactcac ctgctggtgc atgtcgagcc ctgtgaggca   3420
 ccccctcctg tggtggccac tcctcggccc aaaggcagaa acagaagcca cgactggagc   3480
 tccttggcta cccggggcct tccaagcagc atcatgagaa acctgacgcg ctgttggcgg   3540
 gccgtggtgg agaagcaggt gaacaatttt ctgacctcat cctggcggga tgatgacttt   3600
 gtgccacgct actgtgagca ctttaatatt ctgcagaact caagctctga actgtttggg   3660
 cctcgggcag ccttcttgct ggcgctgcaa aatggctgtg cgggagcctt gctgaagctc   3720
 ccttttctca aagctgccca cgagcagcaa gaaatggcac agcaggaacg aaagcaacag   3780
 caggagctgc acctggccct gaagcaagaa cgtcgggctc aggcccagca gggccatcgg   3840
 ccatacttcc tgaaaaaat                                                3859



      <210> 600
      <211> 348
      <212> DNA
      <213> Homo sapiens


      <400> 600
 ctaatcaagc tgaacactag ttgctaggtt ccacggttct cttccgtgac ccacggcttc     60
 taatagagct ataacactca ccgcatggcc caagatttca ttccttggaa tctctttcac    120
 ttctttttct gttgataaac ccgtttggct tccagcttct ccagcacctg tgtaaacaat    180
 tcctgtaccc aaattgaatt tcttctcttg taaatactta aagtggtttc tgatttcttt    240
 gctagatcct ggaagaacac tttccacttt caaattcttc ataagggcct tagtcttcac    300
 cacgggctgg aagacgcgta tgatgtggcc agtcgcggat ccttccat                 348



      <210> 601
      <211> 2726
      <212> DNA
      <213> Homo sapiens


      <400> 601
 atggcaagag acttctgggg ccccagtggc tggactatga ctgtgaccga gctgtgatcg     60
 aggactgggt gttcagggtc ccccatgtgg ccatattcct gagtgtggtc atttgcaagg    120
 gctttctcgt cctgtgctcg tctcttgatc tgactaccct ggtccctgag cgtcaagtgg    180
 accagggcag gggttttgag agcatcctgg atgtcctctc tgtcatgtac atcaacgccc    240
 agctgcctcg ggagcagcgg caccgctggc gcctgctctt ttcgtctgag ctccatggac    300
 acagcttctc ccagctctgt ggccacatca ctcaccgggg gccctgtgtg gctgtcctcg    360
 aggaccatga caagcatgtg ttcggtgggt ttgcctcttg ctcttgggag gtgaagcctc    420
 agtttcaagg ggacaataga tgcttcctgt tctccatctg ccccagcatg gctgtgtaca    480
 cacacacggg ctacaacgac cactacatgt acttgaacca tggacagcag acgatcccga    540
 acggactggg tatggggggg cagcacaatt actttgggct ttgggtggat gttgattttg    600
 ggaaaggaca cagcagagcc aagcccacgt gcaccacgta caacagcccg cagctgtcgg    660
 ctcaggagaa cttccagttt gataagatgg aggtgtgggc ggttggagac ccctcagagg    720
 agcagttggc caagggcaac aagagcatcc tggatgcgga ccctgaggcc caggccctgc    780
 tggagatcag tgggcattcg cgccacagcg aagggctccg ggaagtcccg gacgatgaat    840
 gaggagccgc ctgagccttc ctggagccag gacctggatt cctctgggta gagggcaccg    900
 cctgcagccc ctcttccctc ccacatggtt taactgtaat agcgtaccgc acgggtcaca    960
 gcctggtagt cccacatgtg ccaagaagac gccctctgaa gccatgtcct gactcatggg   1020
 tggatctccc agaaatagat gttttttaag ttttcttttt tgccctacag ggtcaccctc   1080
 aggatctctc caagaaatct tgtgtcaaat tagtaactca gtcttatact ttgttctttt   1140
 ttaccaacga aatcctaagc agctgagacc tttcagaccc ccgcttggca ttagggaatt   1200
 ccgctggcat tagggaattc cgctggcatt agggaattcc gctggcatta gggaattccg   1260
 ctgggcatta gggaattccg ctggcattag ggaattccgc tggcattagc attgctggga   1320
 tctcaacttc tctattgagg agggggttcc tcccgctggg gttcatatgg cctcactcag   1380
 gccatccctg ttagaaggtg gtacctgatg gtctgttctg acgggtgagg gacagaggca   1440
 tctggatgaa aatctcgacg ctttctggga acagcttcca atggcatggg agttctgtat   1500
 ttaaaagcat gaactgtgta taaaatgggg aaatggaggc aggagacttt gaggtaacat   1560
 ggtctggtgg tggcatgagt cctccagaag gtatttgtaa taaggttcca caccccagct   1620
 ctctcagctg tttttaaatg aatgtgtgtg aggaacagat gggaaagttg ggagatctgt   1680
 ctacagagaa gcaaagttgt ggttctcttg ctaacttcaa ggtgagggat attggggcac   1740
 cctaagtttg gggaacttgg ttggataaat acgtatatgg tccattccat aaatcagtgg   1800
 tgagtgactg ggccggggtt ctagacctct gggaaccagc acctgagtca cagctgtcta   1860
 ggcctcggtg ctggcctggg ttctagatct cttgggaacc cagtgcctga gtccaccagc   1920
 tgtccagtgc agccattttg cccagggctg cttcccgagg gggatgatgg gaaattcagc   1980
 agtgtagact cactttaaac aagctccggt gatcctgaaa ttgctgaaga tcgtgtaggt   2040
 gggttgtggg ggtcagcaga gctgccattc ttgcccacgt cttggaaaac aacacacggt   2100
 gagttcaccg tttgggccat gaagattttc cccactttaa aggtgctgtg aacttgtctc   2160
 ctaaagatat atacctcttc cttttgtctt ttgctgtaag ctttggacct tttgcagatc   2220
 tggatgaaaa tacaaccctc ttattgtata ggttggccct tggattatag cccattagta   2280
 aatcggagct gttcggcatt tttgccaggc ccttgcattt tcctacctgg gaggttccat   2340
 caaacccttc ccacttaagc aatagcccct gacctccagg cagaatgccc tcataaatta   2400
 gcccttccgt aagaaaagtg cacgcctcag acagttgtgt ggaggggcag gagcgtgatg   2460
 cagacaagga cttagtcatg actgattttc cttagcccag tttgtaatgg cttatgggga   2520
 acattgtgag cttcctacct gacatgttgg cagaagtaga atattaggat cctcaagcat   2580
 ctctaccgta agtccaaaga atttaggtcc ctattgtcac tttgttttgc aatgtttttt   2640
 ataaaaatgc aattaaatac ctcactatta aactgccatg atgcctcagt taaaaaaaaa   2700
 aattaaatgt ccgtcagtgt ctgaaa                                        2726



      <210> 602
      <211> 394
      <212> DNA
      <213> Homo sapiens


      <400> 602
 cagtatggac tgtacaatgg tggtggtgcc attatggccg ccttgcatga gagctttaca     60
 tcgtgtctga attatggcgg ccctcaaaag ttctccccag aaggtgacct atgttctagc    120
 ccagacccca aaatctgtta tgtgtgcaag aagagtttca aaagctccta cagtgtgaaa    180
 cttcactaca ggaacgttca cttgaaagag atgcacgtct gcacagtggc tggttgcaat    240
 gctgcattcc cctctcgccg aagccgagac agcaaaagat tagaaagctg atcttattgt    300
 cacaagacac agtgccaaca taaacctaca tcgtaaactg ttgaccaaag aactcgatga    360
 catgggcctg gactcgtcgc agccctccct tagc                                394



      <210> 603
      <211> 411
      <212> DNA
      <213> Homo sapiens


      <400> 603
 gcctatggcc cagccgtccc accacagacc ctctacaacc ccgcccagca gatcctggcc     60
 tacgcaggct tccgcctgac gcccgagccc gtcccgacct gctcgtccta ccctctgccc    120
 cttcagccct gcagcccgct tcccagttgc gccctcctct gccctggctt cgtctgagga    180
 cctgcagccc ccttctccaa gcagctctgg ctctgggctt cccggccagg ctccaccgtg    240
 ctacgcaccc acctactttc ccccggggga agaaccaccc ccctacgcac cctgatagag    300
 gcgaggacga atagataacc ttgctcggta ttcttcttac ctcataaggg gatctctttc    360
 acaacccctt ctctcgtccc ctaactccgt gtccatacca ttagcaactc g             411



      <210> 604
      <211> 330
      <212> DNA
      <213> Homo sapiens


      <400> 604
 ggcacgaggt ccggttcttt gtggtggatt gccgtcctgc agaacaatat ggtgctgggc     60
 atttatcaac tgctttccac ttagattcag acctgatgct tcagaatcca tctgagtttg    120
 cacagtcagt aaaatccttg ctggaagcac agaagcagtc cattgagtct ggctccatag    180
 ctggtgggga gcacctctgt tttatgggca gtggcaggga ggaagaagac atgtatatga    240
 acatggtcct ggcacacttt ttacagaaaa acacagaata tgtgagtatt gccagtggag    300
 gatttatggc actgcagcag cacctggcag                                     330



      <210> 605
      <211> 468
      <212> DNA
      <213> Homo sapiens


      <400> 605
 gacggtgcta tgtgctacag gaggtggtgc ttacaagttt gaaaaagatt ttcgcacaat     60
 tggaaacctc cacctgcaca aactggatga acttgactgc cttgtaaagg gcttgctgta    120
 tatagactct gtcagtttca atggacaagc cgagtgctat tattttgcta atgcctcaga    180
 acctgagcga tgccaaaaga tgccttttaa cctggatgat ccctatccac tgcttgtagt    240
 gaacattggc tcaggagtca gtattttagc agtccattcc aaagacaact ataaacgagt    300
 gactgggaca agccttggag ggggtacctt tctgggttta tgcagtttat tgactggctg    360
 tgaaagtttt gaagaggctc ttgaaatggc atccaaaggt gatagcacac aagctgacaa    420
 gctggtccgt gatatttatg gaggagatta tgaaagattt ggtttgcc                 468



      <210> 606
      <211> 374
      <212> DNA
      <213> Homo sapiens


      <400> 606
 cttggtatgt ggtgccccca gaacatggtc agcgcctgga tcgcctggcc agggagctct     60
 tcccaggcag ttcccggtgt tgtggggcct tcctgcggca caaggtggcc ctcatctcgc    120
 ctacagttct caaggaaaat gggattccct tcaatcgcat aactcaggag gctggagagt    180
 tcatggagac ctttccctat ggctaccatg ctggcttcaa ccatggtttc aactgcgcag    240
 aggccatcaa ttttgccact ccgcgatgga ttgattatgg caaaatggcc tcccagtgta    300
 tctgtgggaa ggcaagggtg accttttcca tggatgcctt cgtgcgcatc ctgcaacctg    360
 aacgctatga cctg                                                      374



      <210> 607
      <211> 470
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(470)
      <223> n = a,t,c or g


      <400> 607
 ttgcggagga attcctatca ttcagagata ctggccatca atcaagtgtt tgatatcctg     60
 tccacttact tatagactca caactggcct gaagcattga agaaaggagt ttcttcagga    120
 aaaggctata ttcttcggaa ctcagtggaa tgatgggcct aagattgcag ctgcgnnnnn    180
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    240
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    300
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    360
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    420
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnntaaaaa               470



      <210> 608
      <211> 397
      <212> DNA
      <213> Homo sapiens


      <400> 608
 cgtcgcggga gccgctcaca gctacggtgt cactcagcca ggcgactgcg aaagatccaa     60
 tccttgtggc caatgcggtc gccccaggca acagggggtc ccaggtgggc agctggtaag    120
 atggcccagg ctgttggggt tttcgccgcc ggtggccaga agcgtcttgg agggattcag    180
 ctcgatggca tggatgccgc agccctggtg ggcctgggcc agcccggcct ccttgtcccg    240
 catgaggggg atgcgcgtga tgtggcctga ctgcacgtcc accacaaaca gcgtattaca    300
 cttggtgccg cacaccacct gcctggcgtt cagccactgt gacgcgaaca ccttgttgag    360
 ggtgcccagg tccagctggc gctccgtcag cagctcg                             397



      <210> 609
      <211> 404
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(404)
      <223> n = a,t,c or g


      <400> 609
 aagggcccga cgcgggctgg ggagaccgca ttcccttgga aatcctggtg cagattttcg     60
 ggttgttggt ggcggctgac ggccccatgc ccttcctggg cagggctgcg cgcgtgtgcc    120
 gccgctggca ggaggccgct tcccaacccg cgctctggca caccgtgacc ctgtcgtccc    180
 cgctggtcgg ccggcctgcc aagggcggng tcaaggcgga gaagaagctc cttgcttccc    240
 tggagtggct tatgcccaat cggttttcac agctccagag gctgaccctc atccactgga    300
 agtctcagct ggtaggtgag tgctgtcctc ggctcacttt cctcaagctc tccggctgcc    360
 acggtgtgac tgctgacgct ctggtcatgc tagccaaagc ctgc                     404



      <210> 610
      <211> 1557
      <212> DNA
      <213> Homo sapiens


      <400> 610
 tcagtcatct ttgtctttta ctccatgttt caggatgctt gtgaactcga tgtaattgaa     60
 atttcccttt ttgtcaatag gtgcttctct gtgcagctca tccacttcct catctgtaaa    120
 ctgatccccc atggttgtca tcagctctct caggtaatct tcctgaatgg tgcctgttgc    180
 ttcttcatca aagcaagcag aagcatttct gatgacatct tcaggatctg tgccatttaa    240
 cttctcacca aacatagtga aattaatggg ccctggtgcc tcattcatcg tggcatcaag    300
 gtatgcatca gtgggattct tccccaaaaa gaaaggatga acaacatctg ctgtatcttt    360
 ttctagtttc aggagttcaa tttccaggtt tttctggtag atttcagctt gaatatttgt    420
 gatctgctgt agtctggtga agttcacaaa acaagaaact gttttcttag acatgtttaa    480
 catctcctgc ggagccttac ggcagctgag cggtgggagg cgagtccggg gctccctgat    540
 cttccgtagg ctcccagagg cgcctggcct ccgcagagct gcaaaggcgg cagggcttgg    600
 tggtcgggct gtgtgttctt ccgattcttc cttgtcgctc ttgggtcggg ccccaggagc    660
 cagggatcgg cgggagttga gagctggggc aggagcccca gccgggaggc cgaccgggtg    720
 gactgggcgg tgacagcagc gcttccttcc cgcagggacc tgagccgcgg cgctaggatg    780
 ggaaacagtg cgctccgcgc tcatgtggaa acggcgcaga aaactggtgt ctttcagctt    840
 aaggaccgag ggctgaccga ggtgagactt gtctgtgatt cgttttattt gtggattttg    900
 agcatcaatc tcattgccta tgttcagggc catgtctttt agatttccca ggatactgcc    960
 cacttgagtc aggttctctt ccatttcatc ttctctggca tcattagtta tgcgtttaat   1020
 gtatccacca ctggctgctc ccgttgttgg ttgctgaagc tgaccatttg tcaccgggcc   1080
 tggctgttta gatactacat tgcaaggtga gttttctcca ccatctcccc atgttgtctt   1140
 ataagccttg ccagactcaa agttctttgt tctattacat gggcagacac aaaggccaca   1200
 gcatttgttg agttctgtta aagtcttctc tgtctctctc atgtccttat ttatttggtc   1260
 caagccttct tctatgcggt ttagttgttc cttttgttca tccagcatag tgatggtctt   1320
 gattcctgca tcctgagagg tcaatgacac agataaactc tggttcttat tacagatttg   1380
 accccaggaa tctggcaatg tctggagttg cttgattgtc acaacttggg ccaggtgatg   1440
 gggctggtta atggcatttt taagttcagc attctctttg gcttgataga agtctacgtc   1500
 catggtaacc aatgcatccg cagcaagagg aaacttctgt ttatagcagg atagcat      1557



      <210> 611
      <211> 426
      <212> DNA
      <213> Homo sapiens


      <400> 611
 caatctgacc ggtacactgt ctaaccgcac tccgcctgtg ccaccgtaat ctgccgtgta     60
 cctgtctaac cccacaccgc atgtgccacc gtaatctgac cggtacctgt ctaacccctc    120
 gccgcctgtg ccaccgtaat ctaaccggta cctgtctaac cccacgacgc ctgtgccacg    180
 gtaatctgac cggtacatgt ataacaacac gccgcctgtg ccaccgtaat ctgaacggta    240
 cctgtctaac cccacgccgc ctgtaccacc gtaatatgac cggtacctgt ctaaccgcac    300
 gccgcatgtg tcaccgtagt atgaccggta cctgtctaac cccacgccgc ctgtgtcacc    360
 gtaggacaga gcacaaagga gcacccagga tgcacacctg acacacttcg cggccgagcc    420
 gcaagc                                                               426



      <210> 612
      <211> 459
      <212> DNA
      <213> Homo sapiens


      <400> 612
 ggtaaattac aacctcctca agtatatttg cagattcttg gatgaagtac agtcctactc     60
 gggagttaac aaaatgagtg tgcagaactt ggcaacggtc tttggtccta atatcctgcg    120
 ccccaaagtg gaagatcctt tgactatcat ggagggcact gtggtggtcc agcagttgat    180
 gtcagtgatg attagcaaac atgattgcct ctttcccaaa gatgcagaac tacaaagcaa    240
 gccccaagat ggagtgagca acaacaatga aattcagaag aaagccacca tggggcagtt    300
 acagaacaag gagaacaata acaccaagga cagccctagt aggcagtgct cctgggacaa    360
 gtctgagtca ccccagagaa acagcatgaa caatggatcc cccacagctc tatcaggcag    420
 caaaaccaac agcccaaaga acagtggtca caagctata                           459



      <210> 613
      <211> 1460
      <212> DNA
      <213> Homo sapiens


      <400> 613
 atgaaagaga atttcaaaca caggcacgtg gtggcgttca ttagcagtca ggaagctcag     60
 gaagattcaa gagaggaaga agaccgactg gagtctcggt tttactttct ttttctcttg    120
 gagctgagct ataagacaac aggactgaac agggagccaa ctgtttcttt gaacagtaaa    180
 tcaggaacac caatggacca aaatgaacac agtcactggg gaccacatgc aaagggccaa    240
 tgtgccagca gatctgagct gagaatcatc ctggtgggca aaacaggaac tggcaaaagt    300
 gctgcaggga acagcatcct caggaagcaa gcatttgaat cgaagctggg ttcccagacc    360
 ttgactaaga cttgcagcaa aagtcaggga agctggggaa atagagagat tgtcattatt    420
 gacacaccag atatgttttc ttggaaggac cactgtgaag ctctgtacaa gagaggtgca    480
 gaggtgctac ttggtggctg gaccaagaac cccatgtgct gctcctggtg actcagctgg    540
 gccgctatac ctcacaggac cagcaggctg cacagagggt gaaggagatc tttggagagg    600
 atgccatggg acacacaatt gtcctcttta cccacaagga agacctcaat ggtggctccc    660
 tgatggatta catgcacgac tcagataaca aagccctaag caagctggtg gcagcatgtg    720
 gtgggcgaat ctgtgccttt aataaccgtg ctgaagggag caatcacgat gaccaagtga    780
 aggaactaat ggactgtatt gaggatctgt tgatggagaa aaatggtgat cactatacca    840
 atgggttgta cagcctaata cagaggtcta aatgtggacc tgtgggatca gatgaaagag    900
 taaaggaatt caaacagagc cttataaagt acatggaaac tcaaagaagt tacacagcct    960
 tggctgaagc aaactgccta aaaggagcct taatcaaaac acaactacca aaagtagata   1020
 aaaccacaaa gatagggaaa aaacagagca gaaaaactgg aaactctaaa aagcagagca   1080
 cctctcctcc tccaaaggaa cgcagttcct caccagcaat ggaacaaagc tggacagaga   1140
 atgactttga cgagctgaga gaagaaggct tcagacgatc acattactct gagctaccgg   1200
 aggacattca aaccgaaggc agagaagttg aaaactttga aaaaagttta gaagaatgta   1260
 taactagaat aacccacaca gagaagtgct taaaggagct gatggagctg aaaaccaagg   1320
 ctcgagaact acgtgaagaa tgcagaagcc tcaggagcca atgcgatcaa ctggaagaaa   1380
 gggtgtcagc aatggaagat gaaatgaatg aaatgaagcg agaagggaag tttaaagaaa   1440
 aaaagaataa aaagaaatga                                               1460



      <210> 614
      <211> 1157
      <212> DNA
      <213> Homo sapiens


      <400> 614
 gcgccgccgg tgccggcgaa cgcgctgggc gcgcggggcg aggcggtgcg gctgcagctg     60
 cagggcgagg agctgcggct gcaggagaga gagcgtgcga ctgcaccaga ttaacatcta    120
 cctcagcgac cgcatctcac tgcaccgccg cctgcccgtg cgctggaacc cgctgtgcaa    180
 agagaagaaa tatgattatg ataatttgcc caggacatct gttatcatag cattttataa    240
 tgaagcctgg tcaactctcc ttcggacagt ttacagtgtc cttgagacat ccccggatat    300
 cctgctagaa gaagtgatcc ttgtagatga ctacagtgat agagagcacc tgaaggagcg    360
 cttggccaat gagctttcgg gactgcccaa ggtgcgcctg atccgcgcca acaagagaga    420
 gggccctggt gcgagcccgg ctgctggggg cgtctgcggc gaggggcgat gttctgacct    480
 tcctggactg tcactgtgag tgccacgaag ggtggctgga gccgctgctg cagaggatcc    540
 atgaagagga gtcggcagtg gtgtgcccgg tgactgatgt gatcgactgg aacaccttcg    600
 aatacctggg gaactccggg gagccccaga tcggcggttt cgactggagg ctggtgttca    660
 cgctggcaca cagttcctga gagggagagg atacggatgc aatcccccgt cgatgtcatc    720
 aggtctccaa caatggctgg tgggctgttt gctgtgagta agaaatattt tgaatatctg    780
 gggtcttatg atacaggaat ggaagtttgg ggaggagaaa acctcgaatt ttcctttagg    840
 atctggcagt gtggtggggt tctggaaaca cacccatgtt cccatgttgg ccatgttttc    900
 cccaagcaag ctccctactc ccgcaacaag gctctggcca acagtgttcg tgcagctgaa    960
 gtatggatgg atgaatttaa agagctctac taccatcgca acccccgtgc ccgcttggaa   1020
 ccttttgggg atgtgacaga gaggaagcag ctccgggaca agctccagtg taaagacttc   1080
 aagtggttct tggagactgt gtatccagaa ctgcatgtgc ctgaggacag gcctggcttc   1140
 ttcgggatgc tccagaa                                                  1157



      <210> 615
      <211> 488
      <212> DNA
      <213> Homo sapiens


      <400> 615
 ggcggggccc aggactgctg ctgctgaccg ccttgatagg ctacaccgtg aagaatgcgt     60
 ggaagaacaa cgtcttcttc tcttggtcct atttttctgg gtggctggcc ttacccttct    120
 caattctcgc gggtaaactg gacagcggga agagggtgga ggagactgcc cagaagaccc    180
 tcaccccaga ggctccccag ctgccctccc aggaaacccc ggggacctct cggggactcc    240
 ccaacacact aacgactccc gcagacccgg caaagacccc cttggagccc caaaccccag    300
 tccccggggc cctcccggcc atccgcccca gggcccacct tcctttccct ggtccgcacc    360
 cccgtccccc caggcttctg ctttctgctg gcagacatga tcatgcagag cggcgacgcc    420
 atcagtggat tccccgtgtg tctgtgactg cagcctgcct ggggcagaat aaaggaacgg    480
 cttttttt                                                             488



      <210> 616
      <211> 1778
      <212> DNA
      <213> Homo sapiens


      <400> 616
 atgccagtgt tgcctgtaac tgcaactgaa atccgccagt atttgcgggg gcatgggatc     60
 cccttccagg atggtcacag ttgcctgcgg gcactgagcc cctttgcaga gtcttcacag    120
 ctcaaaggcc agactggtgt taccacttcc ttcagcctct tcattgacaa gaccacaggc    180
 cactttctct gcatgaccag cctagcagaa gggagctggg aagacttcca ggccagcgtg    240
 gaggggcgag gggatggggc cagggagggg tttctgctta gcaaggcacc agaatttgag    300
 gacagcgagg aggtccggag gatctggaac cgagcaatac ctctctggga gctgcctgat    360
 caggaggagg ttcagctggc tgatacaatg tttggcctta ccaaggttac agatgacaca    420
 ctcaagcgtt tcagtgtgcg atatctgcga cctgctcgca gtcttgtctt cccttggttc    480
 tcccctgggg gctcaggatt acgaggcctg aagctcctag aggctaaatg ccagggggat    540
 ggagtgagct acgaggaaac cactattccc cgacccagcg cctaccacaa tctgtttgga    600
 ttaccactga ttagtcgtcg agatgctgag gtggtactga cgagtcgtga gcttgacagc    660
 ctggccttga accagtccac ggggctgcct acccttactc taccccgagg aacgacctgc    720
 ttaccccctg ccttactccc ttacctggaa cagttccggc ggattgtatt ctggttgggg    780
 gatgaccttc ggtcctggga agccgccaag ttgtttgcac gaaaactgaa ccccaaacga    840
 tgcttcttgg tgcgaccagg agaccagcaa ccccgtcccc tggaggccct gaacggaggc    900
 ttcaatcttt ctcgtattct tcgtaccgcc ctgcctgcct ggcacaagtc catcgtatct    960
 ttccggcagc ttcgggagga ggtgctagga gaactgtcaa atgtggagca agcagctggc   1020
 ctccgctgga gccgctttcc agacctcaat cgtatcttga agggacatcg aaagggcgag   1080
 ctgacggtct tcacagggcc aacaggcagt ggaaagacga cattcatcag tgagtatgcc   1140
 ctggatttgt gttcccaggg ggtgaacaca ctgtggggta gcttcgagat cagcaatgtg   1200
 agactagccc gggtcatgct gacacagttt gccgaggggc ggctggaaga tcaactggac   1260
 aaatatgatc actgggctga ccgctttgag gacctgcccc tctatttcat gactttccat   1320
 ggacagcaaa agcatcagga ctgtaatagg tacaatgcaa ccatgcagtc tacgtctatg   1380
 acatttgtca tgtgatcatc gacaacctgc agttcatgat gggtcacgag cagctgtcca   1440
 cagacaggat cgcagctcaa gactacatca tcggggtctt tcggaagttt gcaacagaca   1500
 ataactgcca tgtgacactg gtcattcacc cccggaaaga ggatgatgac aaggaactgc   1560
 agacagcgtc catttttggc tcagccaaag gaggggagtg gtctgccccg cactccacca   1620
 gcagccgacc cagtgcccag cctaagagtg actcgacggt ggccgaggct gcccctctgg   1680
 cctctgactt cacagcttac tggatttggt ttttgacctg gggaaggggg cgagcatcac   1740
 gtgaccgaga attcggctac ctggctgcct taaactaa                           1778



      <210> 617
      <211> 459
      <212> DNA
      <213> Homo sapiens


      <400> 617
 cagcagatcg tccgtggcat gaaccaggtg ctggatgtgc cgctgactgt gaagatccgc     60
 acaggcgtcc aggagcgtgt gaacctggcg caccgcctgc tgcccgagct gcgggactgg    120
 ggcgtggcac tcgtcacgga aatggggaca tcttgtcatt tgaggatgcc aaccgcgcca    180
 tgcagactgg tgtcaccggg atcatgattg cccgtggcgc cctgctcaag ccgtggctct    240
 tcacggagat caaggagcag cggcactggg acatctcgtc gtccgagcgc ctggacatcc    300
 tgcgggactt caccaactac ggcctggagc actggggctc ggacacgcag ggcgtggaga    360
 agacccggcg ctttctgctc gagtggctgt ccttcctgtg ccggtacgtg cccgtggggc    420
 tgctggagcg gctcccacag aggatcaacg agcggccgc                           459



      <210> 618
      <211> 567
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(567)
      <223> n = a,t,c or g


      <400> 618
 gcctgcatgt cgcagcagcg tactgacgtc acgcaggacg ccactgccct gtcgccccgc     60
 ctgtgcagcc caggacctag gcgcggtagc tggggctggc ttttgagggg cgcgggcagc    120
 cttctgactg ggtcggaggc ctgcgggccc gaagcctctg tccctcctgt tcttgtccgg    180
 cgctgcttag ccccctcngc gtagtcatca tggatctgat tttaaaccgg aatggattat    240
 ctgcaggtgg gagtaacatc tcagaagact atgaagctta attcctgcct caagacacag    300
 agctacacaa aaggtggtta ttggagatca tgatggggta gttatgtgct ttggcatgaa    360
 gaaaggagaa gcagcagcag tgttcaagac tttacccggg ccgaagattg caaggctgga    420
 actgggaggg gttatcaaca cacctcagga gaaaattttt attgctgcag catctgagat    480
 tagaggcttc acaaaaaaga ggaaaacagt tcctctcctt tgaaacaaac ctcactgaaa    540
 gcattaaagc tatgtatgtc aaatgtt                                        567



      <210> 619
      <211> 505
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(505)
      <223> n = a,t,c or g


      <400> 619
 tgggannnag agttgatncc cttgncngtt gagaaccgct cggccgaccc acgcgtccgg     60
 cagtagatcg cgatctagaa ctagtccgga cgcgtgggaa tgacttattt tgagctatct    120
 ttcttatact gggacctttc taatctcact acaatatgta acattggtgt tcgatctcaa    180
 gtatttctga atatattccc ctatccacag aaatatactc tgggggaaaa aaaatagaac    240
 aaattcttgc cgtcctgacc attgaacaag agactaatta gacaatgggg ctagaaaaac    300
 ctcaaagtaa actggaagga ggcatgcatc cccagctgat accttcggtt attgctgtag    360
 ttttcatctt acttctagga gtctgtttta ttgcaagttg tttggtgact catcacaact    420
 tttcacgctg taagagaggc acaggagtgc acaagttaaa gcaccatgca aagctcaaat    480
 gcatcaaaga gaaatcagaa ctgag                                          505



      <210> 620
      <211> 563
      <212> DNA
      <213> Homo sapiens


      <400> 620
 taagccccac ccagcccccc agtgcccgtc ttcctgtccc atctgctcag agagaggtgg     60
 ggccgagact tgctggagag cttccctcct ttcccatctg gggagtccgc gggccacagt    120
 gggcaggtgg caccgggggt cagcatgcag gggcgccaga ggcccaggct gctggccgga    180
 cagtcaccct ctgttctcgc tacatccctt gccccctgtc catttattta agcccccata    240
 ggtgcccttc acccccaaaa ccagctgtac agaatctttg atacagacct atttgctagg    300
 ggtgctgccg gggatttggg gtcagcatct ggccccctat ctcctgacca gctgagtcat    360
 gaggccggtt tctctctctc tcccactttt gtcccccagc cccgacctct caggttagac    420
 cctgggccct ggagcttagg gattctcccc accccagccc cacacctgct ccttccctaa    480
 tgctttgagg ttttcttggt tggaagctgc agctggccca agaaagaaaa taaaaaacaa    540
 cacttttgca tgagaaaaaa aaa                                            563



      <210> 621
      <211> 971
      <212> DNA
      <213> Homo sapiens


      <400> 621
 tttttttttt tttttttgaa gttccaacat gctttatttg aggacgagcg ctcaacccgg     60
 gatggagtaa gaagtgggat gggagaagcg tagggttcaa attttctttg tgtctctgtg    120
 atccttaaag catctcagca agctgtagag atggtattaa ggggagagaa aactttgaga    180
 tgacaagagg aaacgttaat accattctca ctccaatgaa acccatgacc acgtttttaa    240
 atgtcctaca gagtcactgg gtgagataag taagatcact gtttcaatac acgatgggga    300
 aagataataa ataaagaagt cttggttttc ttcatttgca ggggaggatt accagggtaa    360
 gaaatggggt aaaaatcggt aaataactat ttactactgt ctctggtgtt ttctcataat    420
 caagccacat aaatacctcc ctacttttcc ctcaactccc agaacaaagc caagactttg    480
 gtaccaattt cttcgtgctt ttcctcaagc aggtaactag gagtatccct actccagcct    540
 tgtgccccta gaactgggct ggagctcaga gacttaccat gactcatggc agctgccttc    600
 cccagctcag tgataaggtc gcccctgcca aacactggag accaaagccc aggtccatca    660
 ctcccatagt gactcctccc ataagctctg cctcagctgt gaaaggcaag agggagaagg    720
 ggagtgaggc tcttgttcct cctcacctag tgggaagata tgcctcttca aggtcccacc    780
 ccagccaggg aggagagggc aggcctcagg cagggtgtgg acacagctgg ttgacactca    840
 gctcagctac agatcggctc agccacagtt gggccggcct gaaccccagg tgcccaccag    900
 cagcaacttg gcccccttgc tctaccttct caccattcgc cagcagtggg tgcaggcagc    960
 catcatcttt c                                                         971



      <210> 622
      <211> 393
      <212> DNA
      <213> Homo sapiens


      <400> 622
 tcaacttatg ggagcagatc tctgcagaat aaaaatgaaa aagcatctga cgaccttctt     60
 ggtgattttg tggctttatt tttatagggg gaatggcaga taccaaccgg agctcagtcc    120
 tcagcccctg atcatcctgg agggaaagaa ctgctctctt cggtgcattt ataccgcgag    180
 ccccttcacc agcttatggc ggtataacca cgatactgga agaggccctg tttccctgac    240
 aatcatgact ttcagtgaga acacaaagcc taacggaaga tatactgcaa ctctggatgc    300
 ggacaccaag caaagctctc tgcacataac agcctaccag ctcatcgatt cagcctccta    360
 catctgtgtg gtgagcgcac tgtgctccac agg                                 393



      <210> 623
      <211> 2894
      <212> DNA
      <213> Homo sapiens


      <400> 623
 tcagtacgcg tctgaccatt gtgcatgccg cccacacttc ggcgtagaat aatgcacctg     60
 gtgcttctca gtatcctcgt tcatcaatgc ttggatatgt acaagacatt gcccaccggc    120
 atacttgtgc tccactacag gcttggtttt taccggggac aaggagacga ggagaacagc    180
 ggcggcaacg gagggcacag gcgcgagcga cggagacagc gagggagaag tgacgacggc    240
 gcagacgcgc agacggaaat gtgcaaccag catcgcagtg ggaacgatgc cctcattcag    300
 catttgcatg gtttgttgaa aaccggacat ggcactccag tcgccttccc gttccgctat    360
 cggctgaatt tgattgcgag tgagatattt atgccagcca gccagacgca gacgcgccga    420
 gacagaactt aatgggcccg ctaacagcgc gatttgctgg tgacccaatg cgaccagatg    480
 ctccacgccc agtcgcgtac cgtcttcatg ggagaaaata atactgttga tgggtgtctg    540
 gtcagagaca tcaagaaata acgccggaac attagtgcag gcagcttcca cagcaatggc    600
 atcctggtca tccagcggat agttaatgat cagcccactg acgcgttgcg cgagaagatt    660
 gtgcaccgcc gctttacagg cttcgacgcc gcttcgttct accatcgaca ccaccacgct    720
 ggcacccagt tgatcggcgc gagatttaat cgccgcgaca atttgcgacg gcgcgtgcag    780
 ggccagactg gaggtggcaa cgccaatcag caacgactgt ttgcccgcca gttgttgtgc    840
 cacgcggttg ggaatgtaat tcagctccgc catcgccgct tccacttttt cccgcgtttt    900
 cgcagaaacg tggctggcct ggttcaccac gcgggaaacg gtctgataag agacaccggc    960
 atactccgtt gtagcgccgg gaagatgctt ttcacgctgg ccctttgggg gtttttttgc   1020
 caaatggtca ttgcaggctt cgccaatata caccagattc agacagccaa cgcggtcgca   1080
 ggcaccttta cagccgccat cgttgtcatt ccacagcact gttgatgccc gctcgctgaa   1140
 tgatatccgg gcgacgcctt cctggtgctg tgccagctct tctttgtagt gctcacgcgg   1200
 catatccgag aacatgcacg gtactgaaac tgccgttgcc gtgccgcaag atgcggtatt   1260
 agggaaatag accacgttat ctttcgccag ccgcgggtta gtttcacgcg ggtagccgtt   1320
 gagggagaag ttctccgccc gcgaggttgc gccgaccatc aggatggtca aatttttacg   1380
 ttgttcgttc tgcattaacg ggttgcggtg cgcgtcttca ccaattcgca ccagcggcag   1440
 atttgccagt cgctgatggg agtaccatga ccagctggca acaatgctgt tagaggggct   1500
 taaggatttc accagctctt tgttattgcg gaacaacgag gcgtagtctt tataaaacag   1560
 tgcggcgacc agcaaaatca gtagtacaga aaccagaata ttggctccac ggaaaagaac   1620
 actgcgcaga cgcgaggtgg caggtttgat ttgtatccag caggcaatca gcgcagcaag   1680
 cacgccgctg aatcccagcg ttgatgacat tggcggtgtc atcagcgcat aactttctgc   1740
 cggagtggta tcaataatat tggcaatcat cgagcggtcg atgacgatgc cgtaagtcat   1800
 tatgaaatat tggtgcagcc gcgccagaat aaacaggcag gccagtggtc gattaagcca   1860
 taagaaagag cttagtgtca ggacaatatt aatcacgctg aaagcgacga ccggcatcga   1920
 caagaaaacc agtacgttat gcagcgaatc cagcggcagc gcctgcaaca ccttaaaaac   1980
 cctgttatga ttggtgctag catcacagaa gttgactgta gtacctgtca ctgatacacg   2040
 gaaaaccaaa ctttggcgga ttatcggaat acctctgtta cctgggtatt cgctggtctg   2100
 ttctagagtg cctttgggct gcttttggcc tggtttccga ttttggctgc gaagcaggcg   2160
 aaaacctgca gcaaactggg tctcggaagt ctccatgggt gagtgtgaat ggtccagcat   2220
 acctgagtga ctcagcagat cattctggag gtcctcgatc agagagaagg gctctctgtc   2280
 ttcactgctg ctttgtagtg gaggaatttc attggctgag ggtaaagttc catccaagaa   2340
 agcttctagt tggttctcta agctggcaga taaactgccc ataggttcgg caaggacgaa   2400
 aatggccaaa acactgtcca cggatgacac cccgtgaaac acatcattag gcccccgaag   2460
 cacacgagtg gaaagaagcc gaacaagagg gtgacccgaa agaatagcat ctttatggac   2520
 gaagtgtaac caagaaagat agaagtcgaa tttcaagagg aagtggtaat tcgtggcatg   2580
 atgccctggt ccactagttg ttctctcgtc ctcctttgtt gcagcctcag ctggagcacc   2640
 caaatagtaa atttttagag tcttgcctat aattgcttct ttaacactgg agtccacagg   2700
 aaggatgttt ttctctacca gctccatagg accaggtctt tgagcaatct tttcattcag   2760
 atcatctgct agtcgagctc ttttcaactt catctgagta gcctgcaggg atggctctgc   2820
 aaatgtttgt ggcatgatgc cctggtccac tagttgttct ctcgtcctcc tttgttgcag   2880
 cctcagctgg agca                                                     2894



      <210> 624
      <211> 1437
      <212> DNA
      <213> Homo sapiens


      <400> 624
 caacaaatgt ttacctgttg ccttgtaatt aactctactc aatttcaata gaatttccat     60
 tatttaaaaa aagcctctaa aattaggaaa gaattcccac atgtggtttt taatatatct    120
 catgcttact tcgaaatata atctgcacta gtctttgtta aagtctgagg gagtcataaa    180
 ataatgtccc tctcctctcc tgacctttga accacttgag acacagacag atggagattc    240
 caatatttta agtttactgc tgaaaaaggc ctaggttaga ggatgtactt taagtttatg    300
 cccaacaata gcccaccaga tattgaactt agaattagac agacctgctt actaaggcat    360
 gggcagttct gcacaagcac aaatctccct ttgcagaggc aaagaacttt cactgcaagg    420
 ttcacaatgt agctggcaag agaccacaac atcggttctc tgcagttacg acaaatccac    480
 aaaagggaaa aaagaggcta gcatgcccag ttctatatct taaactccct cctatcctgg    540
 tgaagtgaga gaaagagatt agaattccct tggtaaatgg atagcctaag aagctctgtg    600
 agaggaagcc atccttaccc gccgctgcct tctgaccaaa gtagttcata tatagtgcac    660
 attagggcat gattcatgtt acagtagctt tagggccaaa acttcctcct cccgaagtac    720
 cccatattta aattgccaag tgacctaagg taaatgactt tagggataac ctcctttatt    780
 tcattttatt tctgttttat aatttatata tttcaatatc ttattattgg taagaaaaac    840
 ttaactttct cagtcctaaa attctttatt atcaaataca tcagtttaat aataatctct    900
 aaggaagaaa aaaacacatt taagatatcc cattggattt ggaagataat tattatggaa    960
 ctatggttcc ttatgtcaac tcacatctca tttagatatt aatacatgta tcatgaacat   1020
 catagctcag aattgctggt ccagagtcac tttagaatgg ctctgattca aggaaattaa   1080
 aagaaatgat tgttaatttt cttagtgctg ggaaaggcag tgaaacaagc ttttgaatca   1140
 ttatgtaatt ttcaaacaac taaaagggct atactgttca gttataatct taaaaattct   1200
 agctgagaca gagcttttaa aaaatcttta tagttttacc atacggcatc aattcaaaag   1260
 attgtcatac tgaaaccact gccataaaat tttgtatgta ggccccagtt gcagtagatc   1320
 tggctcctgt gagctataac ttgcatggct tttcaatgtt tatgtagtgt ctgttaatat   1380
 atttaagata aatactctat aaccaaacag cctgttttct agagaatgat atatgat      1437



      <210> 625
      <211> 868
      <212> DNA
      <213> Homo sapiens


      <400> 625
 ccgacgcctc atcgtggtgc tttcggacgc cttcctgagc cgggcctggt gcagccacag     60
 cttccggtgg gtcccgcgcg gggttgggtg ggccccagcg tagcacccac ccccctgacg    120
 gtcccgcccc gcagggaggg cctgtgccgg ctgctggagc tcacccgcag acccatcttc    180
 atcaccttcg agggccagag gcgcgacccc gccgacccgg cggtccgcct gctgcgccac    240
 agcgcgccac ctggtgacct tgctgctctg gaggcccggc tccgtgactc cttcctccga    300
 tttttggaaa gaagtgcagc tggcgctgcc gcggtaaggt gcagtacagg cctgtggaag    360
 gagaccccca gacgcagctg caggacgaca aggaccccat gctgattctt cgaggcccga    420
 gtccctgagg gccgggccct gggacttcag aggtggaccc ggacccctga aggcggacct    480
 gggtgtccgg gggcctgttt ttggagagcc atcaagctcc accgcacacc agtggggtct    540
 cgctgggaga gagccggagc agcgaagtgg acgtctcgga tctcggctcg cgaaactaca    600
 gtgccccgca cagacttcta cttgccttgg tgtcaaagga tgaatatgta gctcccaccc    660
 cagagtggca ggatcatagg gacagcgggg gccagggcag cggcgtcgct cctctgctca    720
 acaggaccac aacccctgcc agcagccctg ggaccctgcc agcagccctg ggaccctgcc    780
 agcagccctg ggaaaaggct gtggcctcag ggcgcctccc agtgccagaa aataaagtcc    840
 ttttggattc tgaaaaaaaa aaaaaaaa                                       868



      <210> 626
      <211> 804
      <212> DNA
      <213> Homo sapiens


      <400> 626
 cttgaaaata ctttccaaga tgaaaattca tcagggtggg tataattctg atgaaaacgc     60
 ctgtgttcat caacacaggg tcagagcgct caccgggtcg atgtgcaaat ccaagccagg    120
 aagtcctgct ccgggtggaa ggtaaaacct tccctccagg gaaccagggg ctccggcggg    180
 catcggaggc agcttcttgg cctctgctgc tgtgtccccc agtccgccca gcccgcatta    240
 atgtcctctg gaataagagc ctgtggctga agcagagggc cttctgggag agctctccaa    300
 ggtctggaag gagggtcccc cagaaagagc tccggggtag ccccactcgt ggcccccctg    360
 gactccacca gcttcatgct tctcagatgc tatttattgg ccggcccggg gagaccaggg    420
 cagatttctc ccgcaccagg ctgtggaggt ttggagggct gcctgagcag acactgtgcc    480
 attgctgggg ctggggaaag aatatctgag acgacgtttg ggagcaatgc tctttaccac    540
 cgttcaccaa atcgtctggg gcaggggttg tgagctgcag cagttgctgg tgccttgtgg    600
 gaaggtgggg cagggaggag gctgcccgcc acctctgccc ccagtcactt cctgcttgac    660
 ctgactcttc acatgtggat gcttaattcc tgcccctctc cccccagctg cttctccttt    720
 actaacacac ctgctacatt ttacacatgt gttggtaagt gagaaacaga aacgaaaaat    780
 aaattaaaat gcagaaatac aaaa                                           804



      <210> 627
      <211> 513
      <212> DNA
      <213> Homo sapiens


      <400> 627
 atggaggttg cagtgagccg aatcatgaca ctgcactcca gcctgggcga cagagcgaga     60
 ctccatctca aaaaaaaaaa agaagaagaa gaaaaagaag aagaggaaga agaggaagag    120
 gaaaagaaga aggaggagaa ggagaaggag aagaagaagg agaagatgat gaggaggagg    180
 aagaaaacaa aaaacaatac aaaacaaaac aaaacctgtt ccaaacagca ggcactgctg    240
 aggaaggaaa agaactttca caaaaaaagg tggcctgcag caccgggtgt gacagcaagg    300
 tatgccacca gtaaggggga tgtctcagca gctgccagca ctctgcctgt gaaaacgcca    360
 gctccaattc aaagaagagg cgaggtgagt accattcacc tctcccaagt ggtccagtgg    420
 cagtggggcc cccacgcact ctacaccgtt gttgtgttgc tagaggaagg agagcagctg    480
 agccctgggg acctggggac gggcttcatt tga                                 513



      <210> 628
      <211> 697
      <212> DNA
      <213> Homo sapiens


      <400> 628
 ctgaagctca tcgactaggt gcagccactt ggtgatgctg gaatgccctg agacgggcaa     60
 cgggctgctc cacgaagtcc tgctctggga gcccgagccc tcgcccaagg ctctaccgga    120
 gccactgccg gcgcctccag aaaacaagaa gtagccgctg ggccggcggg gcatcgcttg    180
 gtgagcacag ccgcagcagg aggaggcccg agcctgcgcc aggtctgcag cgcagaccac    240
 ctgggcgggc cgttcgctcc ggtgggcggg gccaggtcag ggagaccccc ccaggctgcc    300
 tgggcggggc gtggcatccg agggagccca acggacattc cgctttccgc ttccgtcccg    360
 cggggcccat cggggttttg gggccgcaac cgggaccctc ccggaaaatg accttgtaca    420
 aaagctttcc ctccccttcc ccccaacgcc acggccaagg caggcccccc cccccgctgt    480
 tttccgtgtc aaccgtgttt gattttggga cccccgagcc ccccagggac ccttgagggc    540
 cccatcccgt tatccgagac ccttcctacc ccccattcct cggcgctggg agctattttt    600
 gcccaagggg ggggggatgg gggggctggc gccaccgaac ctgcacatct caacttgtaa    660
 ctcaataaac agaagtgaca atcggaaaaa aaaaaaa                             697



      <210> 629
      <211> 542
      <212> DNA
      <213> Homo sapiens


      <400> 629
 tttttttttt tttttttttg caagaaagaa attgttttta ttgcattgag gacttttcca     60
 gaagcctggt ggaacccacg ttctccctcc agccccaaag gcagtgcaag cctctactga    120
 tcccccactt aaaggtgggt ctcccctcct gcagggccca tggaggaggg gtagggtggg    180
 ctgtaggggg gcccagaagg gaggccctgg ggacagaggg agttcactcc tgtttaagcc    240
 tggagaccag ggagggccca gcctcacctc tgggcaacac agcaagtcag aggctggggt    300
 gtggcagggg ctcagctggt cacctctggg gtgtggcttc ctcccggaac cgcaccagag    360
 gcccctggag cccagggagg gaccacggag ggcaggtgta acccctggcc tggagcacag    420
 ctctcagagc cctgaggctc ccggggacag aaacaagtaa caaagtgaga ccacgagaga    480
 aaaagaatcc acagtttcta caaaaagccc caccctcccc aagcaccctg gtcagctggg    540
 ga                                                                   542



      <210> 630
      <211> 551
      <212> DNA
      <213> Homo sapiens


      <400> 630
 ttactctaag cgcggctctc agaagggtgc aagaagaatc agtgattttt ttttttttcg     60
 aagcactgtg tttagatcaa gatgtctggt aaagcaaatg cttccaagaa aaacgctcaa    120
 cagttaaaaa gaaatccaaa gagaaaaaag gataatgagg aagttgtgtt gtcagagaat    180
 aaggttagaa acacagtgaa aaaaaataaa aatcatctga aagatctgtc ttctgaagga    240
 caaacaaagc acactaacct aaaacacgga aagacagcag ccagcaagag aaaaacctgg    300
 caacctctgt caaagagtac cagagaccat ttgcaaacta tgatggaatc agtaataatg    360
 acaattttga gtaacagtat taaagaaaaa gaagaaatac aataccatct caacttcctg    420
 aagaaaagat tgctacaaca gtgtgaaact ctgaaagtcc ctcccaaaaa gatggaagat    480
 ttaactaatg tatcaagtct actgaatatg gaaagggcac gagacaaagc taatgaagaa    540
 ggtctggcat t                                                         551



      <210> 631
      <211> 401
      <212> DNA
      <213> Homo sapiens


      <400> 631
 tctccgcgta caggaggcgg cggcggcttt cagtctccgg cccccgccgg cgagcgcacg     60
 atgcactgcc tgggcgccga gtacctggtt tctgcagaag gagcccctag gcaaagggag    120
 tggcgacccc agatttatag gaaatgcaca gatacggcat ggttattcct gttctttctc    180
 ttttggactg gtttggtgtt tatcatgggc tactcggtgg tggctggagc cgcgggaaga    240
 ctcctctttg gctatgacag ctttggcaac atgtgtggca agaagaactc ccccgtggaa    300
 ggggcccctc tttcagggca ggacatgacc ctaaaaaaac acgtgttctt tatgaattcc    360
 tgcaacctgg aagtcaaagg tacgcagctc aaccgcatgg c                        401



      <210> 632
      <211> 357
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(357)
      <223> n = a,t,c or g


      <400> 632
 catggcattc ctttggcttg tgtgctgctt tgcccttgtg ggcgccacct ttggctgtgg     60
 ggtccctgcc atccaacccg ggctgaccgg tctgtccagg atcgtcaacg gagaggatgc    120
 tatccctggc tcctggccct ggcaggagtc cctgcaggac agaactggct tccatttctg    180
 cgggggctcc ctcatcagcg aaaactgggt ggtcactgct gcccactgcg gggtcaagac    240
 aaccgatgtg gtggtagctg gagagtttga tcaaggctcc gatgaaaaga atgtccaggt    300
 cctgaaaatc gttcaggttt ttaagaaccc caagttcaac tccttcaccg tgcgtan       357



      <210> 633
      <211> 459
      <212> DNA
      <213> Homo sapiens


      <400> 633
 tccgggtcga cccacccgtc cgacgtcccc ctccaataca cctgccagca tctccccaaa     60
 actgaatgtg gaggtcaaga aggaagtcga caaggagaaa gcggtcactg acgagaaacc    120
 taagcaaaaa gacaagcctg gcgaagaaga ggagaagtgt gacatctctt ccaaatacca    180
 ttacttgact gaaaatgact tagaagagag tcccaagggg gggcttgata tcctcaaatc    240
 cttggaaaac acagtgacat ccgcaatcaa caaggcccag aacggcactc ctagctgggg    300
 gggctatccc agcatccatg ccgcctacca acttcccaac atgatgaagt tgtccctggg    360
 ctcgtcgggg aagagcacgc ccctgaaacc catgtttggc aacagtgaga ttgtctcccc    420
 gacgaaaaac cagaccctgg tctctccacc cagcagccg                           459



      <210> 634
      <211> 450
      <212> DNA
      <213> Homo sapiens


      <400> 634
 atgcgcagtc atgagtcgct tcaagtttat cgatattggt atcaacttga ctgaccctat     60
 gttcagagga atttatttgg gggttcaaaa gcatcaagat gacttacagg atgtaataag    120
 gagagctgtc gagattggtg ttaaaaagtt tatgattaca ggtggaaatc tacaagacag    180
 taaagatgca ctgcatttgg cacaaacaaa tggtatcctc atatttcttt taccaaaaaa    240
 aaaatgaatt aagtaatttt gaagaagtct ttctgaaaac tgcttcaggt atgtttttca    300
 gtacagttgg atgtcatcct acaagatgtg gtgaatttga aaagaataac cctgatcttt    360
 acttaaagga gttgctaaat cttgctgaaa acaataaagg gaaagttgtg ggcaatagga    420
 gaatgcggac ttgattttga ccgactgcaa                                     450



      <210> 635
      <211> 639
      <212> DNA
      <213> Homo sapiens


      <400> 635
 gggatggttc catcatggcg tcaatgcaga aacgactaca gaaagaactg ttggctttgc     60
 aaaatgaccc acctcctgga atgaccttaa atgagaagag tgttcaaaat tcaattacac    120
 acgtggattg tatacatgga aggtgcacca tgtaccttat atgaagggga aaaatttcaa    180
 cttctattta aatgtagaag acgatatcct tttgactctt ctcaaggcat gtttactggt    240
 gaaaatatta ctgatcatcc tcatgtttat agcaatggtc atatgtgctt atccattcta    300
 acaaaaaact ggttcccagc gctctcagtc caatcagttt gtcttaggca ttattagcat    360
 gctttccagc tgcaaggaaa acgacgaccg accacccgga taattctttt tatgtgcgaa    420
 caatgtaaca agaatccaaa gaaaacaaaa tggtggtatc atgatgatac ttgttgatgg    480
 ccactgttat catcctccta gcagaagata gtcctacttg agaaaatgag cactttgatc    540
 cattcagtct ttgaacttta accctttgac tgggaagtga cctataggca atggagacta    600
 ctttccttta ctgcatttta actcgtgtgc attttgggg                           639



      <210> 636
      <211> 572
      <212> DNA
      <213> Homo sapiens


      <400> 636
 gcggcagccg aggccaaaaa gagcgtttgt cgccgtctag attacatcac gcagagcctc     60
 cagcagcagg gcgtgcaggc agaaaatata actgtgacaa aggattttag gagagtggaa    120
 aatgcttatc acatggaagc agagaagtta ctcaggcgtg gtggcgtgtg actgtaatct    180
 cagctaccgg ggaggctgaa gcagaagaaa cgctcgaacc tgggaggcag agcttacagt    240
 gagccgagat cgcaccactg cacttcagcc tgggtgacaa agtgagactc catctacata    300
 catacataca tacatacata catacataca taaaatgccc agtatcttac aagactgtag    360
 ttcacagtgg gtaattcaaa tcagacactg ctcttcaaga gaggtaatat taatagaaat    420
 ctttcaagaa ggattgtttt ctactattaa aacaataaaa ctcttataaa cctgtttatc    480
 agaaggatat ttctgtttca gcaactcctg gaatccttct tcaacatccc aaccaacatt    540
 actcccagat agccatgtca cctgtgaatt at                                  572



      <210> 637
      <211> 409
      <212> DNA
      <213> Homo sapiens


      <400> 637
 aatacattgc ctccatggtt ttaattacct tcattttcag ctgctgcatc cgtacagcgt     60
 cctcctgccc cgccagctct ggcgtctcca tcaacgtgcc cagccgcgtc tgctccagct    120
 cctgcaggct gcgcacgtgg ccggcgagca gcggctgcct gcgaggcccg cccagctctg    180
 cttccaccgc cagcacctcc cgcgaggcgg cggcgaaggc ctgggtcacc ccgtgcactg    240
 tgctccggta gcgcgcgagg tcgtagtcag ggccgctgcg caggtactgg cggtggcctc    300
 tgcggcatgt ggggaccctg aggccgcgcc cccaggctct caggccctgc accggcgcca    360
 accacctgaa aggcccccag gaagtggtcc cagacaccaa aggggagga                409



      <210> 638
      <211> 409
      <212> DNA
      <213> Homo sapiens


      <400> 638
 aatacattgc ctccatggtt ttaattacct tcattttcag ctgctgcatc cgtacagcgt     60
 cctcctgccc cgccagctct ggcgtctcca tcaacgtgcc cagccgcgtc tgctccagct    120
 cctgcaggct gcgcacgtgg ccggcgagca gcggctgcct gcgaggcccg cccagctctg    180
 cttccaccgc cagcacctcc cgcgaggcgg cggcgaaggc ctgggtcacc ccgtgcactg    240
 tgctccggta gcgcgcgagg tcgtagtcag ggccgctgcg caggtactgg cggtggcctc    300
 tgcggcatgt ggggaccctg aggccgcgcc cccaggctct caggccctgc accggcgcca    360
 accacctgaa aggcccccag gaagtggtcc cagacaccaa aggggagga                409



      <210> 639
      <211> 797
      <212> DNA
      <213> Homo sapiens


      <400> 639
 cggacgcgtg ggtgaagctc aacactattt aagtaaaaca ccagagtcat ctgcacaacc     60
 aagtgaaaca attctttggg atgttcagac agactcaaat cctaatcagg aaaaagactc    120
 atctagtaat gagaaacaaa ctattagtct gccagtttct actagcaaat caaggaaaga    180
 gtctacagaa ccaaagacat gtatagaaag tatggaaaag aaaacagaca gtttagttca    240
 gaatggaaac gaacgttctg atgacactgt ttcaaatata agcttgatag accaaaagat    300
 gcctgacata gagccaaatt ctgaaaataa ttgtagtagt agtgatatag tcaatggaca    360
 cagtgaaata gagcaaacac ctttagtttc atcagatcct gctttgaaaa ttgatacaaa    420
 cagaatcagg acagaaaatg gttccatttt gcccagtgtt gtaccacaag aacacaacac    480
 cttgccagta tctcaggcac cttccaaacc aaatctgaca agtgaacata cttcatatgg    540
 cttaatttta acaaaaccat acgtcagacc attgcctccc agttaccttg atgaacggta    600
 tcttagtatg ccaaaacgca gaaaatttct gactgataga gtagatgcct gttctgatca    660
 agataacgtg tataaaaaat cagtgaaaag attaagatgt ggcaaatgcc tgaccaccta    720
 ctgtaatgca gaagcacttg aggctcatct tgcacaaaag aaatgtcaga cactctttgg    780
 gatttgattc agatgat                                                   797



      <210> 640
      <211> 628
      <212> DNA
      <213> Homo sapiens


      <400> 640
 cccacgcgtc cgggagagag gagtgtcaga cagctgttgt caacaggcac ctggccagag     60
 tgaaaaggag gggcagattc catccaagtc ccagcggcgc cagctgacac tctctgccaa    120
 tgcccaggtg ctgagcgaca gtgtcccacc ggtccctgtg cccagaatgg cctgcaccaa    180
 gaccctgcaa cagtcccagc ccatctccgc aggagccacc acaaccacca ccactgtggc    240
 ccctgctggg ggtcattctg gctccacaga atgtgacctg gagtgtctgg tgtgccggga    300
 gccctacagc tgtccccggt tgcccaagct gctggcctgc cagcatgcct tctgcgccat    360
 ctgcctgaag ctcctgctgt gcgtgcagga caacacctgg tccatcacct gcccgctgtg    420
 ccgcaaggtc accgccgtcc ccgggggcct catctgcagc ctgcgcgacc atgaggcggt    480
 ggtggggcag ctggcccagc catgcacaga ggtatcgctc tgtcctcagg ggctggtgga    540
 tcctgctgac ttggcagcag gacaccccag cttggtggga gaggatggac aggatgaagt    600
 aagtgcaaac cacgtggcag cccggcgc                                       628



      <210> 641
      <211> 812
      <212> DNA
      <213> Homo sapiens


      <400> 641
 aagggtactc gaactccagc cagtgaccct gctgctgggt gaccatggct gggtagagca     60
 tgtggataat ggtatccgtt ataagttaga cgtgacccag tgtatgttct cctttggaaa    120
 catcactgag aagcttcgag tggcatcgtt gtcctgtgct ggagaagtgc tggtggatct    180
 ctatgcaggg attggttatt atacattgcc tttcctagtt catgctggtg ctgccttcgt    240
 ccatgcttgt gagtggaatc cccatgctgt agttgctctg agaaataacc ttgagatcaa    300
 tgcgagtagc agatcggtgc caaatacact ttggagataa cagaaaactg aagctctcaa    360
 atattgcaga tagggtgatc ctggggctga ttcccagctc tgaagaaggc tggcccattg    420
 cctgccaagt gttaaggcag gatgctggag gccattttgc atatccacca aaatgtggaa    480
 tctttcccag ggaagaatct tcaggctctt ggagtcagca aagtagagaa agagcattgg    540
 ctgtatcctc agcaaattac caccaaccaa tgggaaaaat gggagctacc agggattcta    600
 ggggaaaaat tgctgtcacc agccaccaag ccacagttgg caaaggtggg cagaatctgc    660
 agaaactcga atcgccactc ttcttcagca ggtgcatggg aaaccatgga agacacaaat    720
 tctgcacatc caaccagtga aatcctatgc tccccatgtg gatcacatag tcctggatct    780
 ggaatgctgc ccctgtcctt cagttggcta ga                                  812



      <210> 642
      <211> 1236
      <212> DNA
      <213> Homo sapiens


      <400> 642
 cgagtccctg tcggtgtcct ttgagcacgg tgctgccgcc atccgccccc accagtgagg     60
 ctgggctgag cctcccgctg cgtggccccc gggcgcggcg ctcggcttcc ccacacgatg    120
 tggacctgtg cctggtgtca ccctgtgaat ttgagcatcg caaggcggtg ccaatggcac    180
 cggcacctgc gtcccccggc agctcgaatg acagcagtgc ccggtcacag gaacgggcag    240
 gtgggctggg ggccgaggag acgccaccca catcggtcag cgagtccctg cccaccctgt    300
 ctgactcgga tcccgttgcc cctggccccc ggtgcggcag actcagacga agacacagag    360
 ggctttggag tccctcgcca cgaccctttg cctgaccccc tcaaggtccc cccaccactg    420
 cctgacccat ccagcatctg catggtggac cccgagatgc tgccccccaa gacagcacgg    480
 caaacggaga acgtcagccg cacccggaag cccctggccc gccccaactc acgcgctgcc    540
 gcccccaaag ccactccagt ggctgctgcc aaaaccaagg ggcttgctgg tggggaccgt    600
 gccagccgac cactcagtgc ccggagtgag cccagtgaga agggaggccg ggcacccctg    660
 tccagaaagt cctcaacccc caagactgcc actcgaggcc cgtcggggtc agccagcagc    720
 cggcccgggg tgtcagccac cccacccaag gtccccggtc tacctggacc tggcctaccc    780
 tgcacagcgg gagcagcgcc cacctggtgg atgaggagtt cttccagcgc gtgcgcgcgc    840
 tctgctacgt catcagtggc caggaccagc gcaaggagga aggcatgcgg gccggtcctg    900
 acgcggctac tgggcagcaa agcagcattt gggaccgtga cctgcaggtg cgtgtcaccc    960
 cagggcctct ggtggtgacc ctgatcccca ctttcgactc ggtggccatg catacgtggt   1020
 acgcagagac gcacgcccgg caccaggcgc tgggcatcac ggtgttgggc agcaacagca   1080
 tggtgtccat gcaggatgac gccttcccgg cctgcaaggt ggagttctag ccccatcgcc   1140
 gacacgcccc ccactcagcc cagcccgcct gtccctagat tcagccacat cagaaataaa   1200
 ctgtgactac acttggcaaa aaaaaaaaaa aaaaaa                             1236



      <210> 643
      <211> 1011
      <212> DNA
      <213> Homo sapiens


      <400> 643
 cctccgtgaa gcccctgctt tcaggggtta gttctggagt ggcccagccc tggggccttc     60
 ccctctgtca ggggaagtga catggtggcc actgatgaga ctgtctgtgt atgttcaggt    120
 tgtgaaggag ctcctgaccc agggagctga ccccaacctg cccctgacca aaggcttggg    180
 cagtgccctg tgtgttgcct gtgacctgac ctactagcac cagaggaaca tggacagcaa    240
 gctggccctg attgaccgac tcatcagtca cggggccgac atcctgaagc ctgtaatgct    300
 caggcaggga gaaaaggagg cagtgggcac agccgtggac tatggctact tcagattctt    360
 ccaggaccgg aggattgccc gctgcccctt ccacacgctg atgccagcag agcgcgagac    420
 gttcctggcg cggaagcggc tcctggagta catgggcttg cagctacggc aggctgtctt    480
 tgccaaggag agccagtggg accccacgtg gctgtacctg tgcaagagag cggagctgat    540
 ccccagccac aggatgaaga agaagggccc cagcctgccc aggggcctgg atgtgaagga    600
 gcaggggcaa attcccttct tcaagttctg ctaccagtgt ggccgctcca tcggggtccg    660
 cctcttgccc tgccctcgct gctacgggat cctgacctgc agcaagtact gcaagaccaa    720
 ggcctggacc gagttccaca agaaggactg cggggacctg gtggccatcg tgacacaact    780
 ggagcaagtt tccaggagga gagaagaatt ccagtgaagc agcagctgca cgtccgaggc    840
 ttggggagga cccaggactg tgtgggtttc ttacctgcct gagccacctc agggaatctt    900
 ccagcctaat gcaggcattt ctgcaccttt ggggtcatgc tttgtagcag tgtctccctt    960
 gcgacctcgc aataaattgg ccccacgggg tgattttgac agtcaaaaaa a            1011



      <210> 644
      <211> 336
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(336)
      <223> n = a,t,c or g


      <400> 644
 aaagttggcc acaccacctg ctgcccagga gtcatcccgc cggcggtcca ggaagggtca     60
 tctgccagcc cccgtgcagc cgtatgaaca cgggtatcca gtctctggcg ggtttgccat    120
 gccacccgtc tccttatacc atatcctcac cacctccttc tcctcccatg ctgttgatat    180
 ctctcttgat atgtgctgtt tcattcttct actaccatct cttctttnnn nnnnnnnnnn    240
 nnnnnnnnnn nnnnnnnnnn nnnataattt ctttctctgt ctttaacttt ttcnnnnnnn    300
 nnnnnnnnnn atctttgata ttagnnnnnn nnnnag                              336



      <210> 645
      <211> 1135
      <212> DNA
      <213> Homo sapiens


      <400> 645
 gtaaatacag gagtctttta attccttgta aggaaaattt cctggataat tccatgtatt     60
 ttaataatca cagagatagt cctatcctta ttcattatca aaaatactgt ggtaacaatt    120
 tatagatgca cacaatctca tctattttga cataaaaaag gcagaaaggc aaaatacaaa    180
 ttctgagaca gagagtaaaa caatacgaca tccttaggtt tatttatttt attgtttgtt    240
 tcactgtttg aatgtttatc ttgcgagagt ctacagaatt gagagaaaat atctgcaggc    300
 taattttaca taacatgagg caaagattaa gcactaaata taaaaaataa aacttttagc    360
 ttgcttatta aactaggaag aattttcctg gaaaccacag cagttaaatt ggtctacaat    420
 gccattaata aatgggagaa cacggatctc gcctatggaa atattttaaa cattgtggga    480
 cggctaccca aaaaggctca ttgggtatat aagagttttc aaggtcacag tcctctaagc    540
 agactaaata caagttagtt tttaaaccct gaaattcagg aagtgccaaa atcctgtaaa    600
 aaataaaaat attccccatt gttcctcagc aatctatgga ttaacccttt acaaatccct    660
 taaaagtctt ttccagtaac atgaacccat gatctccttg acaagttccc ttgccttaag    720
 tggcaagtaa cttttgaagc tggacttctc aatctgtaga gagaagcaag ctgcattcac    780
 agcattgctc ccttttgaaa attatcttct gaagagaaga aggtccagca aagatcttca    840
 gtgcaatact ccctgcatat gtgcaagtct gcatgagagg tccccccaca ggtgcagctg    900
 ccagccaacg aatcagaaac agatgaaaga ggagagaaga aaacagaggt caaacacttc    960
 agtttacaga tgctattcca gataaaatgc caagggcttg gccgggcgcg gtgactcacg   1020
 cctgcaatcc cagcaccttg ggaggccggg gcaggcggat gacgaggtca ggagatcgag   1080
 accatcgtgg ccaacatggt gaaaccccgt ctctactaaa aatccaaaaa aaaaa        1135



      <210> 646
      <211> 898
      <212> DNA
      <213> Homo sapiens


      <400> 646
 ttcagaagaa cactcattac atgatgatct ttgatgcctt tgtcattctg acttgcttgg     60
 tttcattaat cctctgcatt agatctgtga ttagaggact tcagcttcag caggagtttg    120
 tcaatttttt cctcctccat tataagaagg aagtttctgt ttctgatcaa atggaatttg    180
 tcaatggatg gtacattatg attattatta gtgacatatt gacaatcatt ggatcaattc    240
 taaaaatgga aatccaagct aagagtctaa ctagttatga tgtctgtagc atacttcttg    300
 ggacttctac catgctcgtg tggcttggag tcatccgata cctcggtttc tttgcaaagt    360
 acaacctcct cattttgacc cttcaggcag cgctgcccaa tgtcatcagg ttctgctgct    420
 gtgcagctat gatttactta ggttactgct tctgtggatg gatcgtgctg gggccttacc    480
 atgacaagtt tcgttctctg aacatggtct ctgagtgcct tttctctctg ataaatggag    540
 atgatatgtt tgccacgttt gcaaaaatgc agcaaaaaag ttacttagtc tggctgttta    600
 gtagaattta cctctactca ttcatcagcc tctttatata tatgatttta agtcttttca    660
 ttgcactgat cactgataca tacgaaacaa ttaagcaata ccaacaagat ggcttcccag    720
 agactgaact tcgtacattt atatcagaat gcaaagatct acccaactct ggaaaataca    780
 gattagaaga tgaccctcca gtatctttat tctgctgttg taaaaagtag ctatcaggtt    840
 tatctgtact ttagaggaaa atataatgtg tagctgagtt ggaacactgt ggatattt      898



      <210> 647
      <211> 350
      <212> DNA
      <213> Homo sapiens


      <400> 647
 ccctgctgct cgcatcccaa cgcggtgctc ggcgtacagc agacgctgga ggagatggac     60
 ttccagaggg gaatctggtc ggcagccctg aatggagacc tgggccgagt gaagcattta    120
 atccagaagg ccgaggaccc aagtcagccc gactcggccg gctacactgc gctgcactat    180
 gccagccgca atgggcacta cgctgtgtgc cagttcctgc tggaaagcgg agctaagtgt    240
 gatgcccaga cccacggggg tgccactgct ctgcaccgag ccagctactg cgggcacact    300
 gaaatcgggc ggctcctgct atcacatggg tccaacccca aggtggggga               350



      <210> 648
      <211> 350
      <212> DNA
      <213> Homo sapiens


      <400> 648
 ccctgctgct cgcatcccaa cgcggtgctc ggcgtacagc agacgctgga ggagatggac     60
 ttccagaggg gaatctggtc ggcagccctg aatggagacc tgggccgagt gaagcattta    120
 atccagaagg ccgaggaccc aagtcagccc gactcggccg gctacactgc gctgcactat    180
 gccagccgca atgggcacta cgctgtgtgc cagttcctgc tggaaagcgg agctaagtgt    240
 gatgcccaga cccacggggg tgccactgct ctgcaccgag ccagctactg cgggcacact    300
 gaaatcgggc ggctcctgct atcacatggg tccaacccca aggtggggga               350



      <210> 649
      <211> 93
      <212> PRT
      <213> Homo sapiens


      <400> 649
 Arg Gln Leu Leu Glu Gln Ser Arg His Ser Trp Val Asn Thr Thr Val
   1               5                  10                  15    
 Leu Ile Thr Gly Cys Thr Asn Ala Ala Gly Leu Leu Val Val Gly Asn
              20                  25                  30        
 Phe Gln Leu Val Leu Gly Gly Val Phe Phe Val His Glu Ser Ser Gln
          35                  40                  45            
 Leu Gln His Gly Ala Ala Leu Cys Glu Trp Val Cys Val Ile Asp Ile
      50                  55                  60                
 Leu Ile Phe Tyr Gly Thr Phe Ser Tyr Glu Phe Gly Ala Val Ser Ser
  65                  70                  75                  80
 Asp Thr Leu Val Ala Ala Leu His Leu Ala Pro Gly Pro
                  85                  90            



      <210> 650
      <211> 67
      <212> PRT
      <213> Homo sapiens


      <400> 650
 Thr Leu Gln Gln Ala Glu Tyr Glu Phe Leu Ser Phe Val Arg Gln Gln
   1               5                  10                  15    
 Thr Pro Pro Gly Leu Cys Pro Leu Ala Gly Asn Ser Val His Glu Asp
              20                  25                  30        
 Lys Lys Phe Leu Asp Lys Tyr Met Pro Gln Phe Met Lys His Leu His
          35                  40                  45            
 Tyr Arg Ile Ile Asp Val Ser Thr Val Lys Glu Leu Cys Arg Arg Trp
      50                  55                  60                
 Tyr Pro Asp
  65        



      <210> 651
      <211> 107
      <212> PRT
      <213> Homo sapiens


      <400> 651
 Ser Ser Cys His Gly Trp Ile Leu Gly Glu His Gly Asp Ser Ser Val
   1               5                  10                  15    
 Ala Val Trp Ser Gly Val Asn Val Ala Gly Val Ser Leu Gln Glu Leu
              20                  25                  30        
 Asn Pro Glu Met Gly Thr Ala Asn Asp Ser Glu Asn Trp Lys Glu Val
          35                  40                  45            
 His Lys Met Val Val Glu Ser Ala Tyr Glu Val Ile Lys Leu Lys Gly
      50                  55                  60                
 Tyr Thr Asn Trp Ala Ile Gly Leu Thr Ser Val Ile Asn Gln Lys Leu
  65                  70                  75                  80
 Lys Asp Asp Glu Val Ala Gln Leu Lys Lys Ser Ala Asp Thr Leu Trp
                  85                  90                  95    
 Asp Ile Gly Cys Arg Asn Leu Lys Thr Thr Met
             100                 105        



      <210> 652
      <211> 95
      <212> PRT
      <213> Homo sapiens


      <400> 652
 Lys Asn Met Ser Phe Val Asn Asp Leu Thr Val Thr Gln Asp Gly Arg
   1               5                  10                  15    
 Lys Ile Tyr Phe Thr Asp Ser Ser Ser Lys Trp Gln Arg Arg Asp Tyr
              20                  25                  30        
 Leu Leu Leu Val Met Glu Gly Thr Asp Asp Gly Arg Leu Leu Glu Tyr
          35                  40                  45            
 Asp Thr Val Thr Arg Glu Val Lys Val Leu Leu Asp Gln Leu Arg Phe
      50                  55                  60                
 Pro Asn Gly Val Gln Leu Ser Pro Ala Glu Asp Phe Val Leu Val Ala
  65                  70                  75                  80
 Glu Thr Thr Met Ala Arg Ile Arg Ser Ser Leu Val Lys Arg Arg
                  85                  90                  95



      <210> 653
      <211> 130
      <212> PRT
      <213> Homo sapiens


      <400> 653
 Met Asn Arg Thr Val Glu Asn Ser Thr Pro Leu Gln Asp Phe Val Phe
   1               5                  10                  15    
 Thr Ser Ser Phe Thr Asn Pro Lys Pro Asn Pro Leu Leu Lys Ile Ser
              20                  25                  30        
 Leu Ala Ala Leu Pro Arg Ser Ala Tyr Asp Gly Gly Ile His Ile Gly
          35                  40                  45            
 Arg Ala Gln Val Cys Pro Trp Val Ala Met Ala Arg Pro Arg Ala Glu
      50                  55                  60                
 Arg Cys Leu Leu His Phe Ala Leu Gln Leu Leu Gln Leu Gln Pro Asp
  65                  70                  75                  80
 Arg Glu Arg Ala Lys Arg Leu Gln Gln Leu Ala Glu Arg Trp Arg Arg
                  85                  90                  95    
 Pro Pro Ser Gly His His Gln Ile Pro Leu Phe Pro Arg Pro Arg His
             100                 105                 110        
 Gly Asp Pro Arg Thr Asp Leu Arg Ala Ser Asn Val Tyr Ser Ser Ile
         115                 120                 125            
 Ile Cys
     130



      <210> 654
      <211> 1136
      <212> PRT
      <213> Homo sapiens


      <400> 654
 Met Lys Leu Met Glu Thr Leu Asn Gln Cys Ile Asn Ala Gly His Glu
   1               5                  10                  15    
 Met Thr Lys Ala Ile Ala Ile Ala Gln Phe Asn Asp Asp Ser Pro Glu
              20                  25                  30        
 Ala Arg Lys Ile Thr Arg Arg Trp Arg Ile Gly Glu Ala Ala Asp Leu
          35                  40                  45            
 Val Gly Val Ser Ser Gln Ala Ile Arg Asp Ala Glu Lys Ala Gly Arg
      50                  55                  60                
 Leu Pro His Pro Asp Met Glu Ile Arg Gly Arg Val Glu Gln Arg Val
  65                  70                  75                  80
 Gly Tyr Thr Ile Glu Gln Ile Asn His Met Arg Asp Val Phe Gly Thr
                  85                  90                  95    
 Arg Leu Arg Arg Ala Glu Asp Val Phe Pro Pro Val Ile Gly Val Ala
             100                 105                 110        
 Ala His Lys Gly Gly Val Tyr Lys Thr Ser Val Ser Val His Leu Ala
         115                 120                 125            
 Gln Asp Leu Ala Leu Lys Gly Leu Arg Val Leu Leu Val Glu Gly Asn
     130                 135                 140                
 Asp Pro Gln Gly Thr Ala Ser Met Tyr His Gly Trp Val Pro Asp Leu
 145                 150                 155                 160
 His Ile His Ala Glu Asp Thr Leu Leu Pro Phe Tyr Leu Gly Glu Lys
                 165                 170                 175    
 Asp Asp Val Thr Tyr Ala Ile Lys Pro Thr Cys Trp Pro Gly Leu Asp
             180                 185                 190        
 Ile Ile Pro Ser Cys Leu Ala Leu His Arg Ile Glu Thr Glu Leu Met
         195                 200                 205            
 Gly Lys Phe Asp Glu Gly Lys Leu Pro Thr Asp Pro His Leu Met Leu
     210                 215                 220                
 Arg Leu Ala Ile Glu Thr Val Ala His Asp Tyr Asp Val Ile Val Ile
 225                 230                 235                 240
 Asp Ser Ala Pro Asn Leu Gly Ile Gly Thr Ile Asn Val Val Cys Ala
                 245                 250                 255    
 Ala Asp Val Leu Ile Val Pro Thr Pro Ala Glu Leu Phe Asp Tyr Thr
             260                 265                 270        
 Ser Ala Leu Gln Phe Phe Asp Met Leu Arg Asp Leu Leu Lys Asn Val
         275                 280                 285            
 Asp Leu Lys Gly Phe Glu Pro Asp Ser Ala His Asp Pro Pro Ala Val
     290                 295                 300                
 His Leu Ser Asn Gly Pro Gly Gln Glu Pro Ile Ala Val Met Thr Phe
 305                 310                 315                 320
 Asp Leu Thr Lys Ile Thr Lys Thr Ser Ser Ser Phe Glu Val Arg Thr
                 325                 330                 335    
 Trp Asp Pro Glu Gly Val Ile Phe Tyr Gly Asp Thr Asn Pro Lys Asp
             340                 345                 350        
 Asp Trp Phe Met Leu Gly Leu Arg Asp Gly Arg Pro Glu Ile Gln Leu
         355                 360                 365            
 His Asn His Trp Ala Gln Leu Thr Val Gly Ala Gly Pro Arg Leu Asp
     370                 375                 380                
 Asp Gly Arg Trp His Gln Val Glu Val Lys Met Glu Gly Asp Ser Val
 385                 390                 395                 400
 Leu Leu Glu Val Asp Gly Glu Glu Val Leu Arg Leu Arg Gln Val Ser
                 405                 410                 415    
 Gly Pro Leu Thr Ser Lys Arg His Pro Ile Met Arg Ile Ala Leu Gly
             420                 425                 430        
 Gly Leu Leu Phe Pro Ala Ser Asn Leu Arg Leu Pro Leu Val Pro Ala
         435                 440                 445            
 Leu Asp Gly Cys Leu Arg Arg Asp Ser Trp Leu Asp Lys Gln Ala Glu
     450                 455                 460                
 Ile Ser Ala Ser Ala Pro Thr Ser Leu Arg Ser Cys Asp Val Glu Ser
 465                 470                 475                 480
 Asn Pro Gly Ile Phe Leu Pro Pro Gly Thr Gln Ala Glu Phe Asn Leu
                 485                 490                 495    
 Arg Gly Ser Ser Gly Ser Lys Ser Val Gly Pro Leu Arg Gly Leu Val
             500                 505                 510        
 Ala Val Cys Glu Ala Leu Gly Leu Trp Ser Gln Thr Ala Gly Ile Arg
         515                 520                 525            
 Met Ala Ser Val Arg Ile Arg Glu Ala Lys Glu Gly Asp Cys Gly Asp
     530                 535                 540                
 Ile Leu Arg Leu Ile Arg Glu Leu Ala Glu Phe Glu Lys Leu Ser Asp
 545                 550                 555                 560
 Gln Val Lys Ile Ser Glu Glu Gly Pro Cys Val Val Gly Tyr Gly Ile
                 565                 570                 575    
 Tyr Tyr Phe Ile Tyr Ser Thr Trp Lys Gly Arg Thr Ile Tyr Leu Glu
             580                 585                 590        
 Asp Ile Tyr Val Met Pro Glu Tyr Arg Gly Gln Gly Ile Gly Ser Lys
         595                 600                 605            
 Ile Ile Lys Lys Val Ala Glu Val Ala Leu Asp Lys Gly Cys Ser Gln
     610                 615                 620                
 Phe Arg Leu Ala Val Leu Asp Trp Asn Gln Arg Ala Met Asp Leu Tyr
 625                 630                 635                 640
 Lys Ala Leu Gly Ala Gln Asp Leu Thr Glu Ala Glu Gly Trp His Phe
                 645                 650                 655    
 Phe Cys Phe Gln Gly Glu Ala Thr Arg Lys Leu Ala Gly Asn Trp Gln
             660                 665                 670        
 Ser Glu Arg Gln Ile Pro Phe Gly Asp Val Arg Leu Pro Pro Pro Ala
         675                 680                 685            
 Asp Tyr Asn Lys Glu Ile Thr Glu Gly Asp Glu Val Glu Val Tyr Ser
     690                 695                 700                
 Arg Ala Asn Glu Gln Glu Pro Cys Gly Trp Trp Leu Ala Arg Val Arg
 705                 710                 715                 720
 Met Met Lys Gly Asp Lys Val Ala Gln Val Ile His Asn Phe Ser Phe
                 725                 730                 735    
 Phe Thr Met Cys Gln Phe Tyr Val Ile Glu Tyr Ala Ala Cys Asp Ala
             740                 745                 750        
 Thr Tyr Asn Glu Ile Val Thr Leu Glu Arg Leu Arg Pro Val Asn Pro
         755                 760                 765            
 Asn Pro Leu Ala Thr Lys Gly Ser Phe Phe Lys Val Thr Met Ala Val
     770                 775                 780                
 Pro Glu Asp Leu Arg Glu Ala Cys Ser Asn Glu Asn Val His Lys Glu
 785                 790                 795                 800
 Phe Lys Lys Ala Leu Gly Ala Asn Cys Ile Phe Leu Asn Ile Thr Asn
                 805                 810                 815    
 Ser Glu Leu Phe Ile Leu Ser Thr Thr Glu Ala Pro Val Lys Arg Ala
             820                 825                 830        
 Ser Leu Leu Gly Asp Met His Phe Arg Ser Leu Arg Thr Lys Leu Leu
         835                 840                 845            
 Leu Met Ser Arg Asn Glu Glu Ala Thr Lys His Leu Glu Asn Cys Ile
     850                 855                 860                
 Arg Val Arg Asn Ile Glu Thr Lys Leu Val Thr Gly Lys Val Gly Thr
 865                 870                 875                 880
 Gln Asn Thr Gln Leu Leu Gly Asn Thr Leu Thr Gly Ser Thr Ala Ala
                 885                 890                 895    
 Lys Gly Val Gly Val Leu Ile Glu Gly Leu Ala Thr Ser Lys Asn Pro
             900                 905                 910        
 Leu Met Thr Leu Lys Pro Asn Asp Thr Asn Ser Val Tyr Ile Asp Tyr
         915                 920                 925            
 Glu Thr Glu Asp Asp Thr Ser Asp Gly Val Tyr Pro Asn Gln Gly Asn
     930                 935                 940                
 Val Thr Ser Gln Pro Leu His Phe Gln Ala Thr Leu Lys Gln Asp Gly
 945                 950                 955                 960
 Asn Ile Ala Ile Glu Pro Gly Glu Phe Lys Ala Thr Ser Thr Phe Gln
                 965                 970                 975    
 Ala Glu Ala Lys Leu Pro Ser Lys His Pro Ile Cys Ser Lys Phe Arg
             980                 985                 990        
 Gly Ser Leu Gln Arg Met Gly Arg Gly Tyr Trp Ile Gln Leu Phe Phe
         995                1000                1005            
 Ser Pro Pro Val His Pro Asp Tyr Gly Lys Gln Glu Ala Lys Ala Asp
    1010                1015                1020                
 Leu Ser Phe Ser Phe Val Ala Asn Glu Val Leu Ser Glu Arg Arg Glu
1025                1030                1035                1040
 Ala Phe Ile Ser Ile Asp Ser Glu Glu Gly Ala Leu Leu Glu Asp Asn
                1045                1050                1055    
 Gly Met Leu Leu Ala His Trp Ile Ile Tyr Val Ser Glu Ile Cys Asp
            1060                1065                1070        
 Tyr Cys Asn Leu Arg Phe Gln Gly Ser Ser Val Thr Gly Met Ile Ser
        1075                1080                1085            
 Met Asp Gly Ser Tyr Cys Phe Asp Ile His Val Ser Ser Ser Glu Leu
    1090                1095                1100                
 Phe Ser Ser Val Thr Glu His Leu Leu Arg Thr Phe Ser Ser His Ile
1105                1110                1115                1120
 Ile Pro Arg Leu Glu Cys Arg Ser Asp Ala Thr Thr Ser Glu Lys Asp
                1125                1130                1135    





      <210> 655
      <211> 118
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(118)
      <223> Xaa = any amino acid or nothing 


      <400> 655
 Ser Ser Val His Asp Leu Leu Val Ala Ala Met Ser Ala Thr Ser Glu
   1               5                  10                  15    
 Ile Gln Asp Pro Arg Gly Arg Gly Asp Gly Pro Gly Gly Leu Pro Asp
              20                  25                  30        
 Val Val Ala Ile Pro Trp Pro Pro Arg Xaa Ile Leu Ser Gln Glu Glu
          35                  40                  45            
 His His Pro Thr Asp Asn Gln Asp Ile Glu Pro Gly Gln Glu Arg Glu
      50                  55                  60                
 Gly Thr Pro Pro Ile Glu Glu Arg Lys Val Glu Gly Asp Cys Gln Glu
  65                  70                  75                  80
 Met Asp Leu Glu Lys Thr Arg Ser Glu Arg Gly Asp Gly Ser Asp Val
                  85                  90                  95    
 Lys Glu Lys Thr Pro Thr Xaa Ile Leu Lys His Ala Lys Thr Lys Glu
             100                 105                 110        
 Ala Gly Asp Gly Gln Pro
         115            



      <210> 656
      <211> 24
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(24)
      <223> Xaa = any amino acid or nothing 


      <400> 656
 Arg Asn Glu Xaa Leu Leu Thr Arg Phe Ser Pro Leu Ser Leu Ser His
   1               5                  10                  15    
 Xaa Val Leu Gly Val Ser Met Phe
              20                



      <210> 657
      <211> 200
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(200)
      <223> Xaa = any amino acid or nothing 


      <400> 657
 Glu Asn Gly Thr Thr Gly Glu Arg Glu Gly Ser Leu Arg Thr His Pro
   1               5                  10                  15    
 Gly Tyr Pro Arg Ser Pro Leu Gly His His Asp Pro His Cys Cys Lys
              20                  25                  30        
 Pro Phe Leu Leu Ser Thr Ala Gly Gln Pro Pro Asn Tyr Glu Met Leu
          35                  40                  45            
 Lys Glu Glu Gln Glu Val Ala Lys Leu Gly Ala Pro Gln Lys Pro Cys
      50                  55                  60                
 Leu Pro Glu Cys Pro Arg Val Ile Asn Ile Arg Asn Glu Thr Ser Trp
  65                  70                  75                  80
 Pro Asp His Val Arg Leu Val Pro Val Gln His Pro Leu His Glu His
                  85                  90                  95    
 Leu Leu Arg Leu Gly Phe Ile Arg Phe Ala Tyr Ser Val Lys Ser Leu
             100                 105                 110        
 Arg Asp Arg Lys Met Val Gly Asp Val Asn Arg Gly Pro Lys Ala Xaa
         115                 120                 125            
 Cys Leu His Arg Gln Val Pro Glu Asn Leu Gly Pro Asp Phe Gly His
     130                 135                 140                
 Leu His Asp His Phe Cys Ser Ser His His His Pro Val Leu Gly Arg
 145                 150                 155                 160
 Pro Gly Pro Ala Ile Asp Gln Glu Ala Ser Leu Arg Pro Gly Ala Leu
                 165                 170                 175    
 Pro Val Thr Cys Ile Pro Arg Thr Leu Ser Ser Ile Pro Arg Pro Ala
             180                 185                 190        
 Pro Arg Gly Gln Glu Leu Cys Pro
         195                 200



      <210> 658
      <211> 387
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(387)
      <223> Xaa = any amino acid or nothing 


      <400> 658
 Lys Met Ala Glu Glu Val Val Val Val Ala Lys Phe Asp Tyr Val Ala
   1               5                  10                  15    
 Gln Gln Glu Gln Glu Leu Asp Ile Lys Lys Asn Glu Arg Leu Trp Leu
              20                  25                  30        
 Leu Asp Asp Ser Lys Ser Trp Trp Arg Val Arg Asn Ser Met Asn Lys
          35                  40                  45            
 Thr Gly Phe Val Pro Ser Thr Tyr Val Gly Arg Glu Asn Ser Ala Arg
      50                  55                  60                
 Lys Ala Ser Ile Val Lys Asn Leu Lys Asp Thr Leu Gly Ile Gly Lys
  65                  70                  75                  80
 Val Lys Arg Lys Pro Ser Val Pro Asp Ser Ala Ser Pro Ala Asp Asp
                  85                  90                  95    
 Ser Phe Val Asp Pro Gly Glu Arg Leu Tyr Asp Leu Asn Met Pro Ala
             100                 105                 110        
 Tyr Val Lys Phe Asn Tyr Met Ala Glu Arg Glu Asp Glu Leu Ser Leu
         115                 120                 125            
 Ile Lys Gly Thr Lys Val Ile Val Met Glu Lys Cys Ser Asp Gly Trp
     130                 135                 140                
 Trp Arg Gly Thr Tyr Asn Gly Gln Val Gly Trp Phe Pro Ser Asn Tyr
 145                 150                 155                 160
 Val Thr Glu Glu Ser Asp Ser Pro Leu Gly Asp His Val Gly Ser Leu
                 165                 170                 175    
 Ser Glu Lys Leu Ala Ala Val Val Asn Asn Leu Asn Thr Gly Gln Val
             180                 185                 190        
 Leu His Val Val Gln Ala Leu Tyr Pro Phe Ser Ser Ser Asn Asp Glu
         195                 200                 205            
 Glu Leu Asn Phe Glu Lys Gly Asp Val Met Asp Val Ile Glu Lys Pro
     210                 215                 220                
 Glu Asn Asp Pro Glu Trp Trp Lys Cys Arg Lys Ile Asn Gly Met Val
 225                 230                 235                 240
 Gly Leu Val Pro Gln Lys Leu Trp Xaa Pro Leu Leu Gln Ser Ile Gln
                 245                 250                 255    
 Leu Thr Ser Gly Leu Gly Thr Leu Thr Phe Gln Cys Gly Phe Ile Arg
             260                 265                 270        
 Pro Tyr Ile Pro Gly Lys Phe Val Gly Asn Pro Trp Tyr Tyr Gly Lys
         275                 280                 285            
 Val Thr Arg His Gln Ala Glu Met Ala Leu Asn Glu Arg Gly His Glu
     290                 295                 300                
 Gly Asp Phe Leu Ile Arg Asp Ser Glu Ser Ser Pro Asn Asp Phe Ser
 305                 310                 315                 320
 Val Ser Leu Lys Ala Gln Gly Lys Asn Lys His Phe Lys Val Gln Leu
                 325                 330                 335    
 Lys Glu Thr Val Tyr Cys Ile Trp Gln Arg Lys Ser Cys Thr Met Glu
             340                 345                 350        
 Xaa Leu Val Glu His Tyr Lys Lys Ala Pro Asn Phe Tyr Asn Val Asn
         355                 360                 365            
 Lys Gly Glu Lys Leu Tyr Leu Val Lys His Leu Ser Met Ile Leu Leu
     370                 375                 380                
 Thr Gln Lys
 385        



      <210> 659
      <211> 120
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(120)
      <223> Xaa = any amino acid or nothing 


      <400> 659
 Val Val Gly Leu Leu Asp Trp Pro Leu Arg Val Arg Ala Asp Pro Val
   1               5                  10                  15    
 Ser Gly Cys Gly Gly Lys Met Ala Glu Leu Arg Val Leu Glu Leu Ser
              20                  25                  30        
 Arg Gly Ser Ser Thr Thr Pro Xaa Arg Ser Glu Xaa Ser Leu Thr Ala
          35                  40                  45            
 Asp Leu Arg Leu Asn Glu Pro Arg Tyr Ala Thr Leu Pro Asn Ile Met
      50                  55                  60                
 Lys Ala Lys Lys Lys Lys Ile Glu Val Ile Lys Pro Gly Asp Leu Gly
  65                  70                  75                  80
 Val Asp Leu Thr Ser Lys Leu Ser Val Ile Ser Val Glu Asp Pro Pro
                  85                  90                  95    
 Gln Arg Thr Ala Gly Val Lys Val Glu Thr Thr Glu Asp Leu Val Ala
             100                 105                 110        
 Lys Leu Lys Glu Ile Gly Arg Ile
         115                 120



      <210> 660
      <211> 332
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(332)
      <223> Xaa = any amino acid or nothing 


      <400> 660
 Glu Glu Arg Leu Gly Glu Asp Ile Phe Arg Ser Gly Thr Leu Trp Pro
   1               5                  10                  15    
 Asn Ala Gly Gly Arg Ala Phe Ser Gln Ala Val Tyr Cys Leu Asn Gly
              20                  25                  30        
 Phe Ile Asp Thr Ser Val Arg Leu Leu Asp Lys Ile Glu Arg Asn Thr
          35                  40                  45            
 Leu Thr Arg Gln Ser Ser Leu Pro Lys Asp Arg Gly Lys Arg Ser Arg
      50                  55                  60                
 Ala Phe Val Phe Glu Leu Ser Gly Glu His Trp Thr Glu Leu Pro Asp
  65                  70                  75                  80
 Ser Leu Lys Glu Gln Thr His Leu Arg Glu Trp Tyr Ile Ser Asn Thr
                  85                  90                  95    
 Leu Ile Gln Ile Ile Pro Thr Tyr Ile Gln Leu Phe Gln Ala Met Arg
             100                 105                 110        
 Ile Leu Asp Leu Pro Lys Asn Gln Ile Ser His Leu Pro Ala Glu Ile
         115                 120                 125            
 Gly Cys Leu Lys Asn Leu Lys Glu Leu Asn Val Gly Phe Asn Tyr Leu
     130                 135                 140                
 Lys Ser Ile Pro Pro Glu Leu Gly Asp Cys Glu Asn Leu Glu Arg Leu
 145                 150                 155                 160
 Asp Cys Ser Gly Asn Leu Lys Leu Met Glu Leu Pro Phe Glu Leu Ser
                 165                 170                 175    
 Asn Leu Lys Gln Val Thr Phe Val Asp Ile Ser Ala Asn Lys Phe Ser
             180                 185                 190        
 Ser Val Pro Ile Cys Val Leu Arg Met Ser Asn Leu Gln Trp Leu Asp
         195                 200                 205            
 Ile His Arg His Asn Leu Ala Asp Leu Ala Glu Asp Ile Asp Arg Leu
     210                 215                 220                
 Glu Glu Leu Gln Ser Phe Leu Leu Tyr Lys Asn Lys Leu Thr Tyr Leu
 225                 230                 235                 240
 Pro Tyr Ser Met Leu Asn Leu Lys Lys Leu Thr Leu Leu Val Val Ser
                 245                 250                 255    
 Gly Asp His Leu Val Glu Leu Pro Thr Ala Leu Cys Asp Ser Ser Thr
             260                 265                 270        
 Pro Leu Lys Phe Val Ser Leu Met Asp Asn Pro Ile Asp Asn Ala Gln
         275                 280                 285            
 Cys Glu Asp Gly Asn Glu Ile Met Glu Ser Glu Arg Asp Arg Gln His
     290                 295                 300                
 Phe Asp Lys Glu Val Thr Glu Ser Leu Tyr Xaa Ser Pro Xaa Arg Lys
 305                 310                 315                 320
 Arg Ile Cys Ser Gln Leu Tyr His Gln Ser Val Phe
                 325                 330        



      <210> 661
      <211> 109
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(109)
      <223> Xaa = any amino acid or nothing 


      <400> 661
 Arg Pro Leu Lys Pro Arg Arg Thr Phe Cys Lys Xaa Val Cys Lys Ala
   1               5                  10                  15    
 Pro Thr Pro His Lys Ser Asp His Ser Thr Lys Lys Gly Lys Asp Ser
              20                  25                  30        
 Ser Val Arg Pro Gln Gly Lys Arg Arg Tyr Asp Arg Lys Gln Ser Gly
          35                  40                  45            
 Tyr Gly Gly His Thr Lys Pro Ile Phe Arg Ile Lys Ala Lys Thr Thr
      50                  55                  60                
 Glu Lys Ile Val Leu Arg Leu Glu Cys Val Glu Pro Asn Cys Arg Ser
  65                  70                  75                  80
 Lys Arg Met Leu Ala Ile Lys Arg Trp Gln Ala Phe Leu Asn Leu Gly
                  85                  90                  95    
 Gly Asp Lys Lys Arg Lys Gly Pro Ser Ala Ser Lys Phe
             100                 105                



      <210> 662
      <211> 387
      <212> PRT
      <213> Homo sapiens


      <400> 662
 Met Glu Leu Lys Ala Lys Ala Arg Glu Leu Arg Glu Glu Cys Arg Ser
   1               5                  10                  15    
 Leu Arg Ser Arg Cys Asp Gln Leu Glu Glu Arg Val Ser Val Met Glu
              20                  25                  30        
 Asn Glu Met Asn Glu Met Lys Arg Glu Gly Lys Phe Arg Glu Lys Arg
          35                  40                  45            
 Ile Lys Arg Asn Glu Gln Ser Leu Gln Glu Ile Trp Asp Tyr Val Lys
      50                  55                  60                
 Arg Pro Asn Leu His Leu Ile Gly Val Pro Glu Ser Asp Gly Glu Asn
  65                  70                  75                  80
 Gly Thr Lys Leu Glu Asn Thr Leu Gln Asp Ile Ile Gln Glu Asn Phe
                  85                  90                  95    
 Pro Asn Leu Ala Arg Gln Ala Asn Ile Gln Ile Gln Glu Ile Gln Arg
             100                 105                 110        
 Thr Pro Gln Arg Tyr Ser Ser Arg Arg Ala Thr Pro Arg His Ile Ile
         115                 120                 125            
 Val Arg Ile Thr Lys Val Glu Met Lys Glu Lys Met Leu Arg Ala Ala
     130                 135                 140                
 Arg Glu Lys Gly Arg Val Pro His Lys Gly Lys Pro Ile Arg Leu Thr
 145                 150                 155                 160
 Ala Asp Leu Ser Ser Glu Thr Leu Gln Ala Arg Arg Glu Trp Gly Pro
                 165                 170                 175    
 Ile Phe Asn Ile Leu Lys Arg Ile Phe Ser Phe Pro Gln Arg Gly Gly
             180                 185                 190        
 Thr Gly Gly Arg Arg Met Val Lys Leu Thr Ala Glu Leu Ile Glu Gln
         195                 200                 205            
 Ala Ala Gln Tyr Thr Ser Ala Val Arg Asp Arg Glu Leu Asp Leu Arg
     210                 215                 220                
 Gly Tyr Lys Ile Pro Val Ile Glu Asn Leu Gly Ala Thr Leu Asp Gln
 225                 230                 235                 240
 Phe Asp Ala Ile Asp Phe Ser Asp Asn Glu Ile Arg Lys Leu Asp Gly
                 245                 250                 255    
 Phe Pro Leu Leu Arg Arg Leu Lys Thr Leu Leu Val Asn Asn Asn Arg
             260                 265                 270        
 Ile Cys Arg Val Leu Asp Phe Gln Lys Val Lys Leu Lys Glu Arg Gln
         275                 280                 285            
 Glu Ala Glu Lys Met Phe Lys Gly Lys Arg Gly Ala Gln Leu Ala Lys
     290                 295                 300                
 Asp Ile Ala Arg Arg Ser Lys Thr Phe Asn Pro Gly Ala Gly Leu Pro
 305                 310                 315                 320
 Thr Asp Lys Lys Lys Gly Gly Pro Ser Pro Gly Asp Val Glu Ala Ile
                 325                 330                 335    
 Lys Asn Ala Ile Ala Asn Ala Ser Thr Leu Ala Glu Val Glu Arg Leu
             340                 345                 350        
 Lys Gly Leu Leu Gln Ser Gly Gln Ile Pro Gly Arg Glu Arg Arg Leu
         355                 360                 365            
 Gly Pro Thr Asp Asp Gly Glu Glu Glu Met Glu Glu Asp Thr Val Thr
     370                 375                 380                
 Asn Gly Ser
 385        



      <210> 663
      <211> 116
      <212> PRT
      <213> Homo sapiens


      <400> 663
 Pro Ser Thr Phe Val Glu His Ser Ile Ser Cys Lys Glu Lys Leu Asn
   1               5                  10                  15    
 Lys Lys Asn Lys Ile Gly Ala Ala Phe Thr Asp Asp Gly Phe Ala Met
              20                  25                  30        
 Gly Val Ala Tyr Ile Leu Lys Leu Leu Asp Gln Tyr Arg Glu Phe Asp
          35                  40                  45            
 Ser Leu His Trp Phe Gln Ser Val Arg Glu Lys Tyr Leu Lys Glu Ile
      50                  55                  60                
 Arg Ala Val Ala Lys Gln Gln Asn Val Gln Ser Ala Ser Gln Asp Glu
  65                  70                  75                  80
 Lys Leu Leu Gln Thr Met Asn Leu Thr Gln Lys Arg Leu Asp Val Tyr
                  85                  90                  95    
 Leu Gln Ala Arg Ile Phe Phe Arg Ala Asp Lys Thr Ala Ala Glu Glu
             100                 105                 110        
 Asn Gln Glu Lys
         115    



      <210> 664
      <211> 188
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(188)
      <223> Xaa = any amino acid or nothing 


      <400> 664
 Val Ser Arg Ile Arg Gln Asn Ile Ser Thr Arg Arg Xaa Arg Gln Ala
   1               5                  10                  15    
 Cys Leu Thr Ala Leu Val Asn Leu Tyr Leu Gln Gly Leu Pro Pro Pro
              20                  25                  30        
 Thr Ser Leu Trp Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu
          35                  40                  45            
 Gly Val Ser His Phe Phe Arg Arg Ile Gly Pro Arg Lys Lys Arg Glu
      50                  55                  60                
 Gly Tyr Glu Arg Ser Ser Xaa Lys Met Gln Lys Thr Ser Arg Gly Arg
  65                  70                  75                  80
 Pro Ala Leu Phe Phe Gln Asp Asn Gln Asp Ser Gln Leu Glu Asp Glu
                  85                  90                  95    
 Trp Gly Lys Thr Pro Gln Thr Pro Met Lys Ala Ala Met Ala Leu Glu
             100                 105                 110        
 Glu Lys Ala Xaa Thr Gln Ala Leu Phe Gly Ser Phe Ile Ala Leu Gly
         115                 120                 125            
 Phe Leu Pro Ala Arg Thr Pro Met Leu Leu Xaa Ala Ser Leu Glu Thr
     130                 135                 140                
 His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys Met Gly Asp His
 145                 150                 155                 160
 Leu Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala Gly Ala Gly Ala
                 165                 170                 175    
 Lys Tyr Leu Phe Glu Arg Leu Thr Leu Lys His Asp
             180                 185            



      <210> 665
      <211> 209
      <212> PRT
      <213> Homo sapiens


      <400> 665
 Phe Phe Tyr Lys Ser Val Leu Ala Gln Lys Glu Val Arg Cys Val Leu
   1               5                  10                  15    
 Asp Glu Ile Ser Pro Leu Gly Pro Pro Glu Leu Lys Pro Val Arg Met
              20                  25                  30        
 Phe Ala Asp Leu Leu Pro His Glu Ser Arg Arg Asp Ser Ser Val Pro
          35                  40                  45            
 Glu Leu Ala Glu Lys Met Ser Arg Ser Val Asp Val Pro Thr Pro Pro
      50                  55                  60                
 Ser Leu Leu Met Ala Ala Ser Ile Tyr Leu His Asp Gln Asn Pro Asp
  65                  70                  75                  80
 Ala Ala Leu Arg Ala Leu His Gln Gly Asp Ser Leu Glu Cys Thr Ala
                  85                  90                  95    
 Met Thr Met Gln Asp Ala Tyr Tyr Ile Phe Gln Glu Met Ala Asp Lys
             100                 105                 110        
 Cys Ser Pro Thr Leu Leu Leu Leu Asn Gly Gln Ala Ala Cys His Met
         115                 120                 125            
 Ala Gln Gly Arg Trp Glu Ala Ala Glu Gly Leu Leu Gln Glu Ala Leu
     130                 135                 140                
 Asp Lys Asp Ser Gly Tyr Pro Glu Thr Leu Val Asn Leu Ile Val Leu
 145                 150                 155                 160
 Ser Gln His Leu Gly Lys Pro Pro Glu Val Thr Asn Arg Tyr Leu Ser
                 165                 170                 175    
 Gln Leu Lys Asp Ala His Arg Ser His Pro Phe Ile Lys Glu Tyr Gln
             180                 185                 190        
 Ala Lys Glu Asn Asp Phe Asp Arg Leu Val Leu Gln Tyr Ala Pro Ser
         195                 200                 205            
 Ala
    



      <210> 666
      <211> 3257
      <212> PRT
      <213> Homo sapiens


      <400> 666
 Lys Met Trp Pro Thr Arg Arg Leu Val Thr Ile Lys Arg Ser Gly Val
   1               5                  10                  15    
 Asp Gly Pro His Phe Pro Leu Ser Leu Ser Thr Cys Leu Phe Gly Arg
              20                  25                  30        
 Gly Ile Glu Cys Asp Ile Arg Ile Gln Leu Pro Val Val Ser Lys Gln
          35                  40                  45            
 His Cys Lys Ile Glu Ile His Glu Gln Glu Ala Ile Leu His Asn Phe
      50                  55                  60                
 Ser Ser Thr Asn Pro Thr Gln Val Asn Gly Ser Val Ile Asp Glu Pro
  65                  70                  75                  80
 Val Arg Leu Lys His Gly Asp Val Ile Thr Ile Ile Asp Arg Ser Phe
                  85                  90                  95    
 Arg Tyr Glu Asn Glu Ser Leu Gln Asn Gly Arg Lys Ser Thr Glu Phe
             100                 105                 110        
 Pro Arg Lys Ile Arg Asp Arg Arg Pro Ala Arg Arg Val Ser Arg Ser
         115                 120                 125            
 Ser Phe Ser Ser Asp Pro Asp Glu Lys Ala Gln Asp Ser Lys Ala Tyr
     130                 135                 140                
 Ser Lys Ile Thr Glu Gly Lys Val Ser Gly Asn Pro Gln Val His Ile
 145                 150                 155                 160
 Lys Asn Val Lys Glu Asp Ser Thr Ala Asp Asp Ser Lys Asp Ser Val
                 165                 170                 175    
 Ala Gln Gly Thr Thr Asn Val His Ser Ser Glu His Ala Gly Arg Asn
             180                 185                 190        
 Gly Arg Asn Ala Ala Asp Pro Ile Ser Gly Asp Phe Lys Glu Ile Ser
         195                 200                 205            
 Ser Val Lys Leu Val Ser Arg Tyr Gly Glu Leu Lys Ser Val Pro Thr
     210                 215                 220                
 Thr Gln Cys Leu Asp Asn Ser Lys Lys Asn Glu Ser Pro Phe Trp Lys
 225                 230                 235                 240
 Leu Tyr Glu Ser Val Lys Lys Glu Leu Asp Val Lys Ser Gln Lys Glu
                 245                 250                 255    
 Asn Val Leu Gln Tyr Cys Arg Lys Ser Gly Leu Gln Thr Asp Tyr Ala
             260                 265                 270        
 Thr Glu Lys Glu Ser Ala Asp Gly Leu Gln Gly Glu Thr Gln Leu Leu
         275                 280                 285            
 Val Ser Arg Lys Ser Arg Pro Lys Ser Gly Gly Ser Gly His Ala Val
     290                 295                 300                
 Ala Glu Pro Ala Ser Pro Glu Gln Glu Leu Asp Gln Asn Lys Gly Lys
 305                 310                 315                 320
 Gly Arg Asp Val Glu Ser Val Gln Thr Pro Ser Lys Ala Val Gly Ala
                 325                 330                 335    
 Ser Phe Pro Leu Tyr Glu Pro Ala Lys Met Lys Thr Pro Val Gln Tyr
             340                 345                 350        
 Ser Gln Gln Gln Asn Ser Pro Gln Lys His Lys Asn Lys Asp Leu Tyr
         355                 360                 365            
 Thr Thr Gly Arg Arg Glu Ser Val Asn Leu Gly Lys Ser Glu Gly Phe
     370                 375                 380                
 Lys Ala Gly Asp Lys Thr Leu Thr Pro Arg Lys Leu Ser Thr Arg Asn
 385                 390                 395                 400
 Arg Thr Pro Ala Lys Val Glu Asp Ala Ala Asp Ser Ala Thr Lys Pro
                 405                 410                 415    
 Glu Asn Leu Ser Ser Lys Thr Arg Gly Ser Ile Pro Thr Asp Val Glu
             420                 425                 430        
 Val Leu Pro Thr Glu Thr Glu Ile His Asn Glu Pro Phe Leu Thr Leu
         435                 440                 445            
 Trp Leu Thr Gln Val Glu Arg Lys Ile Gln Lys Asp Ser Leu Ser Lys
     450                 455                 460                
 Pro Glu Lys Leu Gly Thr Thr Ala Gly Gln Met Cys Ser Gly Leu Pro
 465                 470                 475                 480
 Gly Leu Ser Ser Val Asp Ile Asn Asn Phe Gly Asp Ser Ile Asn Glu
                 485                 490                 495    
 Ser Glu Gly Ile Pro Leu Lys Arg Arg Arg Val Ser Phe Gly Gly His
             500                 505                 510        
 Leu Arg Pro Glu Leu Phe Asp Glu Asn Leu Pro Pro Asn Thr Pro Leu
         515                 520                 525            
 Lys Arg Gly Glu Ala Pro Thr Lys Arg Lys Ser Leu Val Met His Thr
     530                 535                 540                
 Pro Pro Val Leu Lys Lys Ile Ile Lys Glu Gln Pro Gln Pro Ser Gly
 545                 550                 555                 560
 Lys Gln Glu Ser Gly Ser Glu Ile His Val Glu Val Lys Ala Gln Ser
                 565                 570                 575    
 Leu Val Ile Ser Pro Pro Ala Pro Ser Pro Arg Lys Thr Pro Val Ala
             580                 585                 590        
 Ser Asp Gln Arg Arg Arg Ser Cys Lys Thr Ala Pro Ala Ser Ser Ser
         595                 600                 605            
 Lys Ser Gln Thr Glu Val Pro Lys Arg Gly Gly Glu Arg Val Ala Thr
     610                 615                 620                
 Cys Leu Gln Lys Arg Val Ser Ile Ser Arg Ser Gln His Asp Ile Leu
 625                 630                 635                 640
 Gln Met Ile Cys Ser Lys Arg Arg Ser Gly Ala Ser Glu Ala Asn Leu
                 645                 650                 655    
 Ile Val Ala Lys Ser Trp Ala Asp Val Val Lys Leu Gly Ala Lys Gln
             660                 665                 670        
 Thr Gln Thr Lys Val Ile Lys His Gly Pro Gln Arg Ser Met Asn Lys
         675                 680                 685            
 Arg Gln Arg Arg Pro Ala Thr Pro Lys Lys Pro Val Gly Glu Val His
     690                 695                 700                
 Ser Gln Phe Ser Thr Gly His Ala Asn Ser Pro Cys Thr Ile Ile Ile
 705                 710                 715                 720
 Gly Lys Ala His Thr Glu Lys Val His Val Pro Ala Arg Pro Tyr Arg
                 725                 730                 735    
 Val Leu Asn Asn Phe Ile Ser Asn Gln Lys Met Asp Phe Lys Glu Asp
             740                 745                 750        
 Leu Ser Gly Ile Ala Glu Met Phe Lys Thr Pro Val Lys Glu Gln Pro
         755                 760                 765            
 Gln Leu Thr Ser Thr Cys His Ile Ala Ile Ser Asn Ser Glu Asn Leu
     770                 775                 780                
 Leu Gly Lys Gln Phe Gln Gly Thr Asp Ser Gly Glu Glu Pro Leu Leu
 785                 790                 795                 800
 Pro Thr Ser Glu Ser Phe Gly Gly Asn Val Phe Phe Ser Ala Gln Asn
                 805                 810                 815    
 Ala Ala Lys Gln Pro Ser Asp Lys Cys Ser Ala Ser Pro Pro Leu Arg
             820                 825                 830        
 Arg Gln Cys Ile Arg Glu Asn Gly Asn Val Ala Lys Thr Pro Arg Asn
         835                 840                 845            
 Thr Tyr Lys Met Thr Ser Leu Glu Thr Lys Thr Ser Asp Thr Glu Thr
     850                 855                 860                
 Glu Pro Ser Lys Thr Val Ser Thr Val Asn Arg Ser Gly Arg Ser Thr
 865                 870                 875                 880
 Glu Phe Arg Asn Ile Gln Lys Leu Pro Val Glu Ser Lys Ser Glu Glu
                 885                 890                 895    
 Thr Asn Thr Glu Ile Val Glu Cys Ile Leu Lys Arg Gly Gln Lys Ala
             900                 905                 910        
 Thr Leu Leu Gln Gln Arg Arg Glu Gly Glu Met Lys Glu Ile Glu Arg
         915                 920                 925            
 Pro Phe Glu Thr Tyr Lys Glu Asn Ile Glu Leu Lys Glu Asn Asp Glu
     930                 935                 940                
 Lys Met Lys Ala Met Lys Arg Ser Arg Thr Trp Gly Gln Lys Cys Ala
 945                 950                 955                 960
 Pro Met Ser Asp Leu Thr Asp Leu Lys Ser Leu Pro Asp Thr Glu Leu
                 965                 970                 975    
 Met Lys Asp Thr Ala Arg Gly Gln Asn Leu Leu Gln Thr Gln Asp His
             980                 985                 990        
 Ala Lys Ala Pro Lys Ser Glu Lys Gly Lys Ile Thr Lys Met Pro Cys
         995                1000                1005            
 Gln Ser Leu Gln Pro Glu Pro Ile Asn Thr Pro Thr His Thr Lys Gln
    1010                1015                1020                
 Gln Leu Lys Ala Ser Leu Gly Lys Val Gly Val Lys Glu Glu Leu Leu
1025                1030                1035                1040
 Ala Val Gly Lys Phe Thr Arg Thr Ser Gly Glu Thr Thr His Thr His
                1045                1050                1055    
 Arg Glu Pro Ala Gly Asp Gly Lys Ser Ile Arg Thr Phe Lys Glu Ser
            1060                1065                1070        
 Pro Lys Gln Ile Leu Asp Pro Ala Ala Arg Val Thr Gly Met Lys Lys
        1075                1080                1085            
 Trp Pro Arg Thr Pro Lys Glu Glu Ala Gln Ser Leu Glu Asp Leu Ala
    1090                1095                1100                
 Gly Phe Lys Glu Leu Phe Gln Thr Pro Gly Pro Ser Glu Glu Ser Met
1105                1110                1115                1120
 Thr Asp Glu Lys Thr Thr Lys Ile Ala Cys Lys Ser Pro Pro Pro Glu
                1125                1130                1135    
 Ser Val Asp Thr Pro Thr Ser Thr Lys Gln Trp Pro Lys Arg Ser Leu
            1140                1145                1150        
 Arg Lys Ala Asp Val Glu Glu Glu Phe Leu Ala Leu Arg Lys Leu Thr
        1155                1160                1165            
 Pro Ser Ala Gly Lys Ala Met Leu Thr Pro Lys Pro Ala Gly Gly Asp
    1170                1175                1180                
 Glu Lys Asp Ile Lys Ala Phe Met Gly Thr Pro Val Gln Lys Leu Asp
1185                1190                1195                1200
 Leu Ala Gly Thr Leu Pro Gly Ser Lys Arg Gln Leu Gln Thr Pro Lys
                1205                1210                1215    
 Glu Lys Ala Gln Ala Leu Glu Asp Leu Ala Gly Phe Lys Glu Leu Phe
            1220                1225                1230        
 Gln Thr Pro Gly His Thr Glu Glu Leu Val Ala Ala Gly Lys Thr Thr
        1235                1240                1245            
 Lys Ile Pro Cys Asp Ser Pro Gln Ser Asp Pro Val Asp Thr Pro Thr
    1250                1255                1260                
 Ser Thr Lys Gln Arg Pro Lys Arg Ser Ile Arg Lys Ala Asp Val Glu
1265                1270                1275                1280
 Gly Glu Leu Leu Ala Cys Arg Asn Leu Met Pro Ser Ala Gly Lys Ala
                1285                1290                1295    
 Met His Thr Pro Lys Pro Ser Val Gly Glu Glu Lys Asp Ile Ile Ile
            1300                1305                1310        
 Phe Val Gly Thr Pro Val Gln Lys Leu Asp Leu Thr Glu Asn Leu Thr
        1315                1320                1325            
 Gly Ser Lys Arg Arg Pro Gln Thr Pro Lys Glu Glu Ala Gln Ala Leu
    1330                1335                1340                
 Glu Asp Leu Thr Gly Phe Lys Glu Leu Phe Gln Thr Pro Gly His Thr
1345                1350                1355                1360
 Glu Glu Ala Val Ala Ala Gly Lys Thr Thr Lys Met Pro Cys Glu Ser
                1365                1370                1375    
 Ser Pro Pro Glu Ser Ala Asp Thr Pro Thr Ser Thr Arg Arg Gln Pro
            1380                1385                1390        
 Lys Thr Pro Leu Glu Lys Arg Asp Val Gln Lys Glu Leu Ser Ala Leu
        1395                1400                1405            
 Lys Lys Leu Thr Gln Thr Ser Gly Glu Thr Thr His Thr Asp Lys Val
    1410                1415                1420                
 Pro Gly Gly Glu Asp Lys Ser Ile Asn Ala Phe Arg Glu Thr Ala Lys
1425                1430                1435                1440
 Gln Lys Leu Asp Pro Ala Ala Ser Val Thr Gly Ser Lys Arg His Pro
                1445                1450                1455    
 Lys Thr Lys Glu Lys Ala Gln Pro Leu Glu Asp Leu Ala Gly Trp Lys
            1460                1465                1470        
 Glu Leu Phe Gln Thr Pro Val Cys Thr Asp Lys Pro Thr Thr His Glu
        1475                1480                1485            
 Lys Thr Thr Lys Ile Ala Cys Arg Ser Gln Pro Asp Pro Val Asp Thr
    1490                1495                1500                
 Pro Thr Ser Ser Lys Pro Gln Ser Lys Arg Ser Leu Arg Lys Val Asp
1505                1510                1515                1520
 Val Glu Glu Glu Phe Phe Ala Leu Arg Lys Arg Thr Pro Ser Ala Gly
                1525                1530                1535    
 Lys Ala Met His Thr Pro Lys Pro Ala Val Ser Gly Glu Lys Asn Ile
            1540                1545                1550        
 Tyr Ala Phe Met Gly Thr Pro Val Gln Lys Leu Asp Leu Thr Glu Asn
        1555                1560                1565            
 Leu Thr Gly Ser Lys Arg Arg Leu Gln Thr Pro Lys Glu Lys Ala Gln
    1570                1575                1580                
 Ala Leu Glu Asp Leu Ala Gly Phe Lys Glu Leu Phe Gln Thr Arg Gly
1585                1590                1595                1600
 His Thr Glu Glu Ser Met Thr Asn Asp Lys Thr Ala Lys Val Ala Cys
                1605                1610                1615    
 Lys Ser Ser Gln Pro Asp Leu Asp Lys Asn Pro Ala Ser Ser Lys Arg
            1620                1625                1630        
 Arg Leu Lys Thr Ser Leu Gly Lys Val Gly Val Lys Glu Glu Leu Leu
        1635                1640                1645            
 Ala Val Gly Lys Leu Thr Gln Thr Ser Gly Glu Thr Thr His Thr His
    1650                1655                1660                
 Thr Glu Pro Thr Gly Asp Gly Lys Ser Met Lys Ala Phe Met Glu Ser
1665                1670                1675                1680
 Pro Lys Gln Ile Leu Asp Ser Ala Ala Ser Leu Thr Gly Ser Lys Arg
                1685                1690                1695    
 Gln Leu Arg Thr Pro Lys Gly Lys Ser Glu Val Pro Glu Asp Leu Ala
            1700                1705                1710        
 Gly Phe Ile Glu Leu Phe Gln Thr Pro Ser His Thr Lys Glu Ser Met
        1715                1720                1725            
 Thr Asn Glu Lys Thr Thr Lys Val Ser Tyr Arg Ala Ser Gln Pro Asp
    1730                1735                1740                
 Leu Val Asp Thr Pro Thr Ser Ser Lys Pro Gln Pro Lys Arg Ser Leu
1745                1750                1755                1760
 Arg Lys Ala Asp Thr Glu Glu Glu Phe Leu Ala Phe Arg Lys Gln Thr
                1765                1770                1775    
 Pro Ser Ala Gly Lys Ala Met His Thr Pro Lys Pro Ala Val Gly Glu
            1780                1785                1790        
 Glu Lys Asp Ile Asn Thr Phe Leu Gly Thr Pro Val Gln Lys Leu Asp
        1795                1800                1805            
 Gln Pro Gly Asn Leu Pro Gly Ser Asn Arg Arg Leu Gln Thr Arg Lys
    1810                1815                1820                
 Glu Lys Ala Gln Ala Leu Glu Glu Leu Thr Gly Phe Arg Glu Leu Phe
1825                1830                1835                1840
 Gln Thr Pro Cys Thr Asp Asn Pro Thr Ala Asp Glu Lys Thr Thr Lys
                1845                1850                1855    
 Lys Ile Leu Cys Lys Ser Pro Gln Ser Asp Pro Ala Asp Thr Pro Thr
            1860                1865                1870        
 Asn Thr Lys Gln Arg Pro Lys Arg Ser Leu Lys Lys Ala Asp Val Glu
        1875                1880                1885            
 Glu Glu Phe Leu Ala Phe Arg Lys Leu Thr Pro Ser Ala Gly Lys Ala
    1890                1895                1900                
 Met His Thr Pro Lys Ala Ala Val Gly Glu Glu Lys Asp Ile Asn Thr
1905                1910                1915                1920
 Phe Val Gly Thr Pro Val Glu Lys Leu Asp Leu Leu Gly Asn Leu Pro
                1925                1930                1935    
 Gly Ser Lys Arg Arg Pro Gln Thr Pro Lys Glu Lys Ala Lys Ala Leu
            1940                1945                1950        
 Glu Asp Leu Ala Gly Phe Lys Glu Leu Phe Gln Thr Pro Gly His Thr
        1955                1960                1965            
 Glu Glu Ser Met Thr Asp Asp Lys Ile Thr Glu Val Ser Cys Lys Ser
    1970                1975                1980                
 Pro Gln Pro Asp Pro Val Lys Thr Pro Thr Ser Ser Lys Gln Arg Leu
1985                1990                1995                2000
 Lys Ile Ser Leu Gly Lys Val Gly Val Lys Glu Glu Val Leu Pro Val
                2005                2010                2015    
 Gly Lys Leu Thr Gln Thr Ser Gly Lys Thr Thr Gln Thr His Arg Glu
            2020                2025                2030        
 Thr Ala Gly Asp Gly Lys Ser Ile Lys Ala Phe Lys Glu Ser Ala Lys
        2035                2040                2045            
 Gln Met Leu Asp Pro Ala Asn Tyr Gly Thr Gly Met Glu Arg Trp Pro
    2050                2055                2060                
 Arg Thr Pro Lys Glu Glu Ala Gln Ser Leu Glu Asp Leu Ala Gly Phe
2065                2070                2075                2080
 Lys Glu Leu Phe Gln Thr Pro Asp His Thr Glu Glu Ser Thr Thr Asp
                2085                2090                2095    
 Asp Lys Thr Thr Lys Ile Ala Cys Lys Ser Pro Pro Pro Glu Ser Met
            2100                2105                2110        
 Asp Thr Pro Thr Ser Thr Arg Arg Arg Pro Lys Thr Pro Leu Gly Lys
        2115                2120                2125            
 Arg Asp Ile Val Glu Glu Leu Ser Ala Leu Lys Gln Leu Thr Gln Thr
    2130                2135                2140                
 Thr His Thr Asp Lys Val Pro Gly Asp Glu Asp Lys Gly Ile Asn Val
2145                2150                2155                2160
 Phe Arg Glu Thr Ala Lys Gln Lys Leu Asp Pro Ala Ala Ser Val Thr
                2165                2170                2175    
 Gly Ser Lys Arg Gln Pro Arg Thr Pro Lys Gly Lys Ala Gln Pro Leu
            2180                2185                2190        
 Glu Asp Leu Ala Gly Leu Lys Glu Leu Phe Gln Thr Pro Val Cys Thr
        2195                2200                2205            
 Asp Lys Pro Thr Thr His Glu Lys Thr Thr Lys Ile Ala Cys Arg Ser
    2210                2215                2220                
 Pro Gln Pro Asp Pro Val Gly Thr Pro Thr Ile Phe Lys Pro Gln Ser
2225                2230                2235                2240
 Lys Arg Ser Leu Arg Lys Ala Asp Val Glu Glu Glu Ser Leu Ala Leu
                2245                2250                2255    
 Arg Lys Arg Thr Pro Ser Val Gly Lys Ala Met Asp Thr Pro Lys Pro
            2260                2265                2270        
 Ala Gly Gly Asp Glu Lys Asp Met Lys Ala Phe Met Gly Thr Pro Val
        2275                2280                2285            
 Gln Lys Leu Asp Leu Pro Gly Asn Leu Pro Gly Ser Lys Arg Trp Pro
    2290                2295                2300                
 Gln Thr Pro Lys Glu Lys Ala Gln Ala Leu Glu Asp Leu Ala Gly Phe
2305                2310                2315                2320
 Lys Glu Leu Phe Gln Thr Pro Gly Thr Asp Lys Pro Thr Thr Asp Glu
                2325                2330                2335    
 Lys Thr Thr Lys Ile Ala Cys Lys Ser Pro Gln Pro Asp Pro Val Asp
            2340                2345                2350        
 Thr Pro Ala Ser Thr Lys Gln Arg Pro Lys Arg Asn Leu Arg Lys Ala
        2355                2360                2365            
 Asp Val Glu Glu Glu Phe Leu Ala Leu Arg Lys Arg Thr Pro Ser Ala
    2370                2375                2380                
 Gly Lys Ala Met Asp Thr Pro Lys Pro Ala Val Ser Asp Glu Lys Asn
2385                2390                2395                2400
 Ile Asn Thr Phe Val Glu Thr Pro Val Gln Lys Leu Asp Leu Leu Gly
                2405                2410                2415    
 Asn Leu Pro Gly Ser Lys Arg Gln Pro Gln Thr Pro Lys Glu Lys Ala
            2420                2425                2430        
 Glu Ala Leu Glu Asp Leu Val Gly Phe Lys Glu Leu Phe Gln Thr Pro
        2435                2440                2445            
 Gly His Thr Glu Glu Ser Met Thr Asp Asp Lys Ile Thr Glu Val Ser
    2450                2455                2460                
 Cys Lys Ser Pro Gln Pro Glu Ser Phe Lys Thr Ser Arg Ser Ser Lys
2465                2470                2475                2480
 Gln Arg Leu Lys Ile Pro Leu Val Lys Val Asp Met Lys Glu Glu Pro
                2485                2490                2495    
 Leu Ala Val Ser Lys Leu Thr Arg Thr Ser Gly Glu Thr Thr Gln Thr
            2500                2505                2510        
 His Thr Glu Pro Thr Gly Asp Ser Lys Ser Ile Lys Ala Phe Lys Glu
        2515                2520                2525            
 Ser Pro Lys Gln Ile Leu Asp Pro Ala Ala Ser Val Thr Gly Ser Arg
    2530                2535                2540                
 Arg Gln Leu Arg Thr Arg Lys Glu Lys Ala Arg Ala Leu Glu Asp Leu
2545                2550                2555                2560
 Val Asp Phe Lys Glu Leu Phe Ser Ala Pro Gly His Thr Glu Glu Ser
                2565                2570                2575    
 Met Thr Ile Asp Lys Asn Thr Lys Ile Pro Cys Lys Ser Pro Pro Pro
            2580                2585                2590        
 Glu Leu Thr Asp Thr Ala Thr Ser Thr Lys Arg Cys Pro Lys Thr Arg
        2595                2600                2605            
 Pro Arg Lys Glu Val Lys Glu Glu Leu Ser Ala Val Glu Arg Leu Thr
    2610                2615                2620                
 Gln Thr Ser Gly Gln Ser Thr His Thr His Lys Glu Pro Ala Ser Gly
2625                2630                2635                2640
 Asp Glu Gly Ile Lys Val Leu Lys Gln Arg Ala Lys Lys Lys Pro Asn
                2645                2650                2655    
 Pro Val Glu Glu Glu Pro Ser Arg Arg Arg Pro Arg Ala Pro Lys Glu
            2660                2665                2670        
 Lys Ala Gln Pro Leu Glu Asp Leu Ala Gly Phe Thr Glu Leu Ser Glu
        2675                2680                2685            
 Thr Ser Gly His Thr Gln Glu Ser Leu Thr Ala Gly Lys Ala Thr Lys
    2690                2695                2700                
 Ile Pro Cys Glu Ser Pro Pro Leu Glu Val Val Asp Thr Thr Ala Ser
2705                2710                2715                2720
 Thr Lys Arg His Leu Arg Thr Arg Val Gln Lys Val Gln Val Lys Glu
                2725                2730                2735    
 Glu Pro Ser Ala Val Lys Phe Thr Gln Thr Ser Gly Glu Thr Thr Asp
            2740                2745                2750        
 Ala Asp Lys Glu Pro Ala Gly Glu Asp Lys Gly Ile Lys Ala Leu Lys
        2755                2760                2765            
 Glu Ser Ala Lys Gln Thr Pro Ala Pro Ala Ala Ser Val Thr Gly Ser
    2770                2775                2780                
 Arg Arg Arg Pro Arg Ala Pro Arg Glu Ser Ala Gln Ala Ile Glu Asp
2785                2790                2795                2800
 Leu Ala Gly Phe Lys Asp Pro Ala Ala Gly His Thr Glu Glu Ser Met
                2805                2810                2815    
 Thr Asp Asp Lys Thr Thr Lys Ile Pro Cys Lys Ser Ser Pro Glu Leu
            2820                2825                2830        
 Glu Asp Thr Ala Thr Ser Ser Lys Arg Arg Pro Arg Thr Arg Ala Gln
        2835                2840                2845            
 Lys Val Glu Val Lys Glu Glu Leu Leu Ala Val Gly Lys Leu Thr Gln
    2850                2855                2860                
 Thr Ser Gly Glu Thr Thr His Thr Asp Lys Glu Pro Val Gly Glu Gly
2865                2870                2875                2880
 Lys Gly Thr Lys Ala Phe Lys Gln Pro Ala Lys Arg Asn Val Asp Ala
                2885                2890                2895    
 Glu Asp Val Ile Gly Ser Arg Arg Gln Pro Arg Ala Pro Lys Glu Lys
            2900                2905                2910        
 Ala Gln Pro Leu Glu Asp Leu Ala Ser Phe Gln Glu Leu Ser Gln Thr
        2915                2920                2925            
 Pro Gly His Thr Glu Glu Leu Ala Asn Gly Ala Ala Asp Ser Phe Thr
    2930                2935                2940                
 Ser Ala Pro Lys Gln Thr Pro Asp Ser Gly Lys Pro Leu Lys Ile Ser
2945                2950                2955                2960
 Arg Arg Val Leu Arg Ala Pro Lys Val Glu Pro Val Gly Asp Val Val
                2965                2970                2975    
 Ser Thr Arg Asp Pro Val Lys Ser Gln Ser Lys Ser Asn Thr Ser Leu
            2980                2985                2990        
 Pro Pro Leu Pro Phe Lys Arg Gly Gly Gly Lys Asp Gly Ser Val Thr
        2995                3000                3005            
 Gly Thr Lys Arg Leu Arg Cys Met Pro Ala Pro Glu Glu Ile Val Glu
    3010                3015                3020                
 Glu Leu Pro Ala Ser Lys Lys Gln Arg Val Ala Pro Arg Ala Arg Gly
3025                3030                3035                3040
 Lys Ser Ser Glu Pro Val Val Ile Met Lys Arg Ser Leu Arg Thr Ser
                3045                3050                3055    
 Ala Lys Arg Ile Glu Pro Ala Glu Glu Leu Asn Ser Asn Asp Met Lys
            3060                3065                3070        
 Thr Asn Lys Glu Glu His Lys Leu Gln Asp Ser Val Pro Glu Asn Lys
        3075                3080                3085            
 Gly Ile Ser Leu Arg Ser Arg Arg Gln Asp Lys Thr Glu Ala Glu Gln
    3090                3095                3100                
 Gln Ile Thr Glu Val Phe Val Leu Ala Glu Arg Ile Glu Ile Asn Arg
3105                3110                3115                3120
 Asn Glu Lys Lys Pro Met Lys Thr Ser Pro Glu Met Asp Ile Gln Asn
                3125                3130                3135    
 Pro Asp Asp Gly Ala Arg Lys Pro Ile Pro Arg Asp Lys Val Thr Glu
            3140                3145                3150        
 Asn Lys Arg Cys Leu Arg Ser Ala Arg Gln Asn Glu Ser Ser Gln Pro
        3155                3160                3165            
 Lys Val Ala Glu Glu Ser Gly Gly Gln Lys Ser Ala Lys Val Leu Met
    3170                3175                3180                
 Gln Asn Gln Lys Gly Lys Gly Glu Ala Gly Asn Ser Asp Ser Met Cys
3185                3190                3195                3200
 Leu Arg Ser Arg Lys Thr Lys Ser Gln Pro Ala Ala Ser Thr Leu Glu
                3205                3210                3215    
 Ser Lys Ser Val Gln Arg Val Thr Arg Ser Val Lys Arg Cys Ala Glu
            3220                3225                3230        
 Asn Pro Lys Lys Ala Glu Asp Asn Val Cys Val Lys Lys Ile Thr Thr
        3235                3240                3245            
 Arg Ser His Arg Asp Ser Glu Asp Ile
    3250                3255        



      <210> 667
      <211> 88
      <212> PRT
      <213> Homo sapiens


      <400> 667
 Val Gly Gly Gly Thr Gly Phe Ile Gly Thr Ala Leu Thr Gln Leu Leu
   1               5                  10                  15    
 Asn Ala Arg Gly His Glu Val Thr Leu Val Ser Arg Lys Pro Gly Pro
              20                  25                  30        
 Gly Arg Ile Thr Trp Asp Glu Leu Ala Ala Ser Gly Leu Pro Ser Cys
          35                  40                  45            
 Asp Ala Ala Val Asn Leu Ala Gly Glu Asn Ile Leu Asn Pro Leu Arg
      50                  55                  60                
 Arg Ser Ala Arg Ala Leu Lys Leu Ile Pro Thr Arg Ala Gln Gly Gly
  65                  70                  75                  80
 Gln Cys Pro Thr Asp Glu Asn Leu
                  85            



      <210> 668
      <211> 191
      <212> PRT
      <213> Homo sapiens


      <400> 668
 Glu Phe Ile Phe Pro Ser Pro Leu Val Leu Phe Pro Ile Arg Ile Met
   1               5                  10                  15    
 Lys Met Gly Leu Leu Cys Glu Val Ser Ala Ala Val Pro Ala Val Leu
              20                  25                  30        
 Phe Leu Thr Asp Leu Val Gly Leu Gly Pro Cys Leu Lys Ala Lys Asn
          35                  40                  45            
 Val Ser Val Phe Phe Phe Phe Val Phe Val Leu Val Met Cys Asn Leu
      50                  55                  60                
 Ser Leu Ile Thr Val Glu Gln Ile Ser Leu Thr Gln Ile Thr Arg Glu
  65                  70                  75                  80
 Gly Lys Gly Ala Ser Ala Arg Asn Thr Asn Leu Phe Leu Phe Cys Phe
                  85                  90                  95    
 Gly Glu Gln Lys Trp Ser Lys Gly Lys Val Arg Asp Lys Leu Asn Asn
             100                 105                 110        
 Leu Val Leu Phe Asp Lys Ala Thr Tyr Asp Lys Leu Cys Lys Glu Val
         115                 120                 125            
 Pro Asn Tyr Lys Leu Ile Thr Pro Ala Val Val Ser Glu Arg Leu Lys
     130                 135                 140                
 Ile Arg Gly Ser Leu Ala Arg Ala Ala Leu Gln Glu Leu Leu Ser Lys
 145                 150                 155                 160
 Gly Leu Ile Lys Leu Val Ser Lys His Arg Ala Gln Val Ile Tyr Thr
                 165                 170                 175    
 Arg Asn Thr Lys Gly Gly Asp Ala Pro Ala Ala Gly Glu Asp Ala
             180                 185                 190    



      <210> 669
      <211> 236
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(236)
      <223> Xaa = any amino acid or nothing 


      <400> 669
 Met Ala Gly Ala Ala Pro Arg Leu Pro Trp Ser Arg Pro His Gly Ser
   1               5                  10                  15    
 Cys Gly Trp Trp Pro Met Gln Pro Leu Gln Gly Pro Gly Arg Arg Ala
              20                  25                  30        
 Val Ala Ala Ala Trp Glu Val Ala Thr Pro Val Phe Met Pro Val Gly
          35                  40                  45            
 Thr Gln Ala Thr Met Lys Ala Ser Arg Pro Asn Ser Trp Thr Leu Trp
      50                  55                  60                
 Val Ala Ala Ser Ala Trp Glu Tyr Leu Pro Ser Gly Ser Lys Ala Gly
  65                  70                  75                  80
 Gly Thr Ala Ala Phe Pro Asp Gly Val Ala Gly Val Ser Val Arg Gly
                  85                  90                  95    
 Asp Gly Gly Gly Leu Arg Phe Arg Ser Pro Tyr Asp Gly Asn Glu Thr
             100                 105                 110        
 Leu Leu Ser Pro Glu Asn Pro Cys Arg Ser Arg Met Arg Trp Ala Pro
         115                 120                 125            
 Gly Val Val Thr Gly Ala Leu Leu Gln Val Asn Pro Leu Ala Gly Pro
     130                 135                 140                
 Val His Ala Ala His Gln Arg Pro Asp Lys Gln Asn Leu Phe Ala Ile
 145                 150                 155                 160
 Ile Gln Val Gly Trp Thr Gln Ile Ser Gly Pro Pro Ala Leu Lys Arg
                 165                 170                 175    
 Phe Gly Ser Ala Trp His Ser Arg Ala Phe Leu Thr His Cys Cys Thr
             180                 185                 190        
 Val Thr Thr Arg Pro Arg Cys Thr Thr Ser Arg Pro Gln His Arg Leu
         195                 200                 205            
 Pro Ala Glu Leu Met Ser Ala Val Arg Thr Ser Ile Val Glu Lys Arg
     210                 215                 220                
 Phe Pro Asp Ser Cys Gly Thr Ser Trp Ala Pro Xaa
 225                 230                 235    



      <210> 670
      <211> 267
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(267)
      <223> Xaa = any amino acid or nothing 


      <400> 670
 Glu Gly Pro Ala Glu Glu Asn Met Ala Ala Lys Val Phe Glu Ser Ile
   1               5                  10                  15    
 Gly Lys Phe Gly Leu Ala Leu Ser Val Gln Asp Ser Met Val Asn Ser
              20                  25                  30        
 Ala Leu Cys Asn Val Tyr Ala Gly His Arg Ala Ala Ile Phe Asp Gln
          35                  40                  45            
 Phe Arg Gly Val Gln Asn Ile Val Val Trp Glu Gly Thr His Phe Leu
      50                  55                  60                
 Ile Pro Trp Val Arg Lys Pro Ile Met Phe Asp Cys Cys Ser Gln Pro
  65                  70                  75                  80
 Arg Ser Pro Pro Val Ile Thr Gly Ser Lys Asp Leu Gln Asn Val Asn
                  85                  90                  95    
 Ile Thr Leu Cys Ile Leu Phe Arg Pro Ile Thr Ser Gln Leu Pro Arg
             100                 105                 110        
 Ile Phe Thr Ser Ile Gly Glu Asp Tyr Asp Glu Cys Val Leu Pro Phe
         115                 120                 125            
 Ile Thr Thr Glu Ile Leu Lys Ser Leu Val Ala Arg Phe Asp Ala Gly
     130                 135                 140                
 Glu Leu Ile Thr Gln Arg Glu Leu Val Ser Ser Gln Val Ser Asn Asn
 145                 150                 155                 160
 Leu Met Glu Xaa Ala Ala Thr Phe Gly Leu Ile Leu Asp Asp Val Ser
                 165                 170                 175    
 Leu Thr His Leu Thr Phe Leu Lys Glu Leu Thr Glu Gln Val Ala Pro
             180                 185                 190        
 Gln Glu Ala Glu Ser Ala Arg Phe Val Val Glu Lys Ala Ala Ile Ile
         195                 200                 205            
 Ser Ala Glu Gly Asp Ser Lys Ala Ala Glu Leu Ile Ala Asn Ser Leu
     210                 215                 220                
 Ala Thr Ala Gly Asp Gly Gln Ser Glu Leu Cys Lys Leu Glu Ala Ala
 225                 230                 235                 240
 Glu Asp Ile Ala Tyr Gln Leu Ser Cys Ser Arg Asn Ile Thr Cys Leu
                 245                 250                 255    
 Pro Ala Gly Gln Ser Val Leu Leu Gln Leu Pro
             260                 265        



      <210> 671
      <211> 208
      <212> PRT
      <213> Homo sapiens


      <400> 671
 Gly Pro Ala Val Pro Arg Trp Met Gly Gln Arg Pro Gly Ser Gly Gly
   1               5                  10                  15    
 Trp Thr Ala Val Ala Lys Pro Gly Glu Leu Gly Leu Pro His Pro Leu
              20                  25                  30        
 Ser Thr Gly Gly Leu Pro Val Ala Ser Glu Asp Gly Ala Leu Arg Ala
          35                  40                  45            
 Pro Glu Ser Gln Ser Val Thr Pro Lys Pro Leu Glu Thr Glu Pro Ser
      50                  55                  60                
 Arg Glu Thr Ala Trp Ser Ile Gly Leu Gln Val Thr Val Pro Phe Met
  65                  70                  75                  80
 Phe Ala Gly Leu Gly Leu Ser Trp Ala Gly Met Leu Leu Asp Tyr Phe
                  85                  90                  95    
 Gln Ala Asn Thr Gly Gln Ile Asp Asp Pro Gln Glu Gln His Arg Val
             100                 105                 110        
 Ile Ser Ser Asn Leu Ala Leu Ile Gln Val Gln Ala Thr Val Val Gly
         115                 120                 125            
 Leu Leu Ala Ala Val Ala Ala Leu Leu Leu Gly Val Val Ser Arg Glu
     130                 135                 140                
 Glu Val Asp Val Ala Lys Val Glu Leu Leu Cys Ala Ser Ser Val Leu
 145                 150                 155                 160
 Thr Ala Phe Leu Ala Ala Phe Ala Leu Gly Val Leu Met Val Cys Ile
                 165                 170                 175    
 Val Ile Gly Ala Arg Lys Leu Gly Val Asn Pro Asp Asn Ile Ala Thr
             180                 185                 190        
 Pro Ile Ala Ala Arg Pro Gly Asp Leu Ile Thr Leu Ser Ile Leu Ala
         195                 200                 205            





      <210> 672
      <211> 61
      <212> PRT
      <213> Homo sapiens


      <400> 672
 Arg Trp Arg Gly His Ser Leu His Glu Ile Phe Lys Arg Ser Val Thr
   1               5                  10                  15    
 Gln Asn Asn Leu Ile Glu Tyr Arg Ile Pro Ile Met Ser Leu Cys Cys
              20                  25                  30        
 Ala Ser Asp Thr Arg Gln Ser Phe Asn Thr Thr Ser Val Pro Ala Val
          35                  40                  45            
 Lys Lys Leu Thr Val Thr Val Asn Thr Ile Ser Ile Phe
      50                  55                  60    



      <210> 673
      <211> 302
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(302)
      <223> Xaa = any amino acid or nothing 


      <400> 673
 Ala Leu Arg Gln Ser His Ser Gln Lys Leu Arg Arg Leu Trp Thr Ala
   1               5                  10                  15    
 Ala Ser Gln Gly Ser Met Pro Asp Lys Ala Cys Val Val Thr Leu Ala
              20                  25                  30        
 Thr Ile Ala Trp Met Val Ser Phe Val Ser Asn Tyr Ser His Thr Ala
          35                  40                  45            
 Asn Ile Leu Pro Asp Ile Glu Asn Glu Asp Phe Ile Lys Asp Cys Val
      50                  55                  60                
 Arg Ile His Asn Lys Phe Arg Ser Glu Val Lys Pro Thr Ser Gln Val
  65                  70                  75                  80
 Ile Cys Leu Tyr Met Thr Trp Asp Pro Ala Leu Ala Gln Ile Ala Lys
                  85                  90                  95    
 Ala Trp Ala Ser Asn Cys Gln Phe Ser His Asn Thr Arg Leu Lys Pro
             100                 105                 110        
 Pro Pro Gln Ala Trp His Pro Asn Phe His Phe His Trp Gly Glu Asn
         115                 120                 125            
 Ile Trp Asp Leu Gly Leu Leu Pro Ile Phe Ser Val Ser Ser Ala Ile
     130                 135                 140                
 Thr Asn Trp Tyr Asp Glu Ile Gln Asp Tyr Asp Phe Lys Thr Arg Ile
 145                 150                 155                 160
 Cys Lys Lys Val Cys Gly His Tyr Thr Gln Val Val Trp Ala Asp Ser
                 165                 170                 175    
 Tyr Lys Val Gly Cys Ala Val Ser Ile Leu Ala Leu Lys Val Ser Gly
             180                 185                 190        
 Phe Asp Arg Leu Ser Pro Asn Gly Ala His Phe Tyr Met Gln Leu Pro
         195                 200                 205            
 Gly Pro Gly Gly Asn Tyr Pro Thr Thr Trp Pro Tyr Lys Arg Gly Ala
     210                 215                 220                
 Thr Leu Cys Ser Ala Cys Pro Asn Asn Asp Lys Cys Leu Asp Asn Leu
 225                 230                 235                 240
 Cys Val Asn Arg Gln Arg Asp Gln Val Lys Arg Tyr Tyr Ser Val Val
                 245                 250                 255    
 Tyr Pro Gly Trp Pro Ile Tyr Pro Arg Xaa Gln Arg Arg Ser Ser Leu
             260                 265                 270        
 Phe Leu Ile Gly Asn Ser Val Ile Leu Ile Leu Cys Val Ile Ile Thr
         275                 280                 285            
 Ile Leu Val Gln His Lys Tyr Pro Asn Leu Val Leu Leu Asp
     290                 295                 300        



      <210> 674
      <211> 164
      <212> PRT
      <213> Homo sapiens


      <400> 674
 Ala Ser Gly Ser Val Ile Thr Ser Gly Ile Trp Ala Ser Arg Pro Arg
   1               5                  10                  15    
 Ile Arg Thr Ile Ala Pro Ser Glu Thr Pro Ser Ser Ser Phe Val Val
              20                  25                  30        
 Phe Lys Arg Arg Lys Arg Arg Arg Lys Ser His Leu Ala Ser Leu Lys
          35                  40                  45            
 Arg Asp Asp Asn Met Asn Thr Ser Glu Asp Glu Asp Met Phe Pro Ile
      50                  55                  60                
 Glu Met Ser Ser Asp Glu Ala Met Glu Leu Leu Glu Ser Ser Arg Thr
  65                  70                  75                  80
 Leu Pro Asn Asp Ile Pro Pro Phe Gln Asp Asp Ile Pro Glu Glu Asn
                  85                  90                  95    
 Leu Ser Leu Ala Val Ile Tyr Pro Gln Ser Ala Ser Tyr Pro Asn Ser
             100                 105                 110        
 Asp Arg Glu Trp Ser Pro Thr Pro Ser Ser Leu Val Asp Cys Lys Arg
         115                 120                 125            
 Thr Ala Pro His Leu Ala Val Ala Ala Glu Gly Gly Leu Ser Ser Ser
     130                 135                 140                
 Cys Pro Pro Gln Ser Ser Leu Phe His Pro Ser Glu Ser Pro Ser Gly
 145                 150                 155                 160
 Ser Arg Pro Ser
                



      <210> 675
      <211> 286
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(286)
      <223> Xaa = any amino acid or nothing 


      <400> 675
 Ser Asn Leu Ile Leu Arg Asn Leu Phe Cys Pro His Leu Ala Leu Ala
   1               5                  10                  15    
 Ser Ser Ala Phe Asp Lys Cys Gln Glu Glu Glu Thr Val Glu Lys Thr
              20                  25                  30        
 Glu Leu Leu Ala Glu Arg Arg Gly Leu Thr Glu Asn Pro Ser Arg Leu
          35                  40                  45            
 Pro Pro Ile Thr Ala Gly Leu Arg Ser Asp Thr Met Asn His Ile Val
      50                  55                  60                
 Ala Asn Leu Leu Leu Ser Cys Gln Gln Arg Pro Arg Leu Pro Asn Tyr
  65                  70                  75                  80
 Glu Met Leu Lys Glu Glu His Glu Val Ala Val Leu Gly Ala Pro Gln
                  85                  90                  95    
 Lys Pro Cys Leu Pro Glu Cys Pro Pro Val Ile His Tyr Pro Gln Ala
             100                 105                 110        
 Arg Pro Pro Trp Pro Asp His Val Arg Leu Val Pro Val Gln Thr Pro
         115                 120                 125            
 Ser Ser Met Asn Pro Cys Met Pro Trp Ala Ser Xaa Ala Phe Ala Tyr
     130                 135                 140                
 Ser Val Lys Ser Leu Arg Asp Arg Lys Met Val Gly Asp Val Glu Pro
 145                 150                 155                 160
 Gly Pro Gln Gly Leu Met Pro Pro Pro Ala Lys Val Pro Glu Lys Ser
                 165                 170                 175    
 Gly Pro Val Ile Leu Gly His Leu His Glu Pro Ile Leu Ala His His
             180                 185                 190        
 His Pro Pro Pro Ser Val Gly Arg Pro Gly Pro Asn Gly Xaa Ile Lys
         195                 200                 205            
 Glu Gly Ile Thr Glu Gly Gln Gly Ala Leu Pro Arg Xaa Thr Cys Asn
     210                 215                 220                
 Pro Thr Val Leu Gln Leu Ser Ile Pro Arg Pro Ala Pro Arg Gly Gln
 225                 230                 235                 240
 Glu Val Leu Pro Leu Asn Cys Ile Pro Leu Thr Pro Pro Ser Ile Pro
                 245                 250                 255    
 Arg Pro Val Pro Thr Ala Glu Ser Cys Ile Ser Pro Leu Ser Ser His
             260                 265                 270        
 Ala Phe Leu Gln Trp His Ser Ile Lys Cys Ile Cys Phe Trp
         275                 280                 285    



      <210> 676
      <211> 213
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(213)
      <223> Xaa = any amino acid or nothing 


      <400> 676
 Thr Pro His Phe His Gln Gly Thr Gly Lys Arg Ala Ala Trp Pro Thr
   1               5                  10                  15    
 Cys Phe Lys Pro Ala Gly Pro Gly Lys Ile Arg Gln Thr Xaa Arg Pro
              20                  25                  30        
 Arg Lys Ala Gln Arg Arg Arg Arg Ile Ala Pro Arg Pro Arg Val Gly
          35                  40                  45            
 Val Pro Ile Arg Pro Ile Val Arg Cys Pro Thr Val Arg Val His Thr
      50                  55                  60                
 Lys Val Arg Ala Gly Pro Arg Leu Pro Ala Leu Arg Lys Leu Arg Val
  65                  70                  75                  80
 Ala Gly Ile His Lys Lys Val Ala Arg Thr Phe Gly Ile Ser Val Asp
                  85                  90                  95    
 Pro Arg Lys Pro Asp Gln Val Pro Arg Ser Ser Phe Lys Ala Asn Val
             100                 105                 110        
 Gln Arg Leu Lys Glu Tyr Arg Ser Lys Leu Ile Leu Phe Pro Gln Arg
         115                 120                 125            
 Ser Pro Arg Pro Pro Lys Lys Gly Asp Arg Ser Ala Glu Glu Leu Lys
     130                 135                 140                
 Leu Ala Thr Gln Leu Thr Gly Pro Val Met Pro Val Arg Asn Val Gln
 145                 150                 155                 160
 Lys Lys Glu Lys Ala Arg Val Ile Thr Glu Gln Glu Lys Asn Phe Lys
                 165                 170                 175    
 Ala Phe Ala Ser Leu Arg Met Ala Arg Ala Asn Ala Pro Ala Leu Arg
             180                 185                 190        
 His Thr Gly Gln Lys Glu Pro Arg Glu Ala Ala Glu Pro Gly Cys Xaa
         195                 200                 205            
 Lys Ala His Asn Lys
     210            



      <210> 677
      <211> 292
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(292)
      <223> Xaa = any amino acid or nothing 


      <400> 677
 Ala Cys Ala Pro Leu Val Ala Ala Ser Gly Ser Glu Val Arg Arg Ser
   1               5                  10                  15    
 Ser Ala Ala Trp Ala Met Val Gln Leu Arg Pro Arg Ala Ser Arg Ala
              20                  25                  30        
 Pro Ala Ser Ala Glu Ala Met Val Asp Glu Gly Gln Leu Ala Ser Glu
          35                  40                  45            
 Glu Glu Glu Ala Glu His Gly Leu Leu Leu Gly Gln Pro Ser Ser Gly
      50                  55                  60                
 Ala Ala Ala Glu Pro Leu Glu Glu Asp Glu Glu Gly Asp Asp Glu Phe
  65                  70                  75                  80
 Asp Asp Gly Gly Pro Glu Glu His Asn Leu Phe Ala Ser Ala Gln Ala
                  85                  90                  95    
 Glu Ala Arg Glu Glu Glu Arg Arg Val Arg Glu Thr Val Arg Arg Asp
             100                 105                 110        
 Lys Thr Leu Leu Lys Glu Lys Arg Lys Arg Thr Arg Glu Glu Leu Phe
         115                 120                 125            
 Ile Glu Gln Lys Lys Arg Lys Leu Leu Pro Asp Thr Ile Leu Glu Lys
     130                 135                 140                
 Leu Thr Thr Ala Ser Gln Thr Asn Ile Lys Lys Phe Pro Arg Lys Arg
 145                 150                 155                 160
 Xaa Lys Lys Val Asn Leu Gln Lys Lys Asn Glu Asp Cys Glu Lys Gly
                 165                 170                 175    
 Asn Asp Ser Lys Lys Val Lys Val Gln Lys Val Gln Ser Val Ser Pro
             180                 185                 190        
 Glu Xaa Lys Leu Ala Ser Ala Val Arg Leu Lys Gly Pro Arg Phe Trp
         195                 200                 205            
 Arg Asp Ser Arg Gln Gln Ala Ala Gln Ala Phe Ile His Asn Ser Leu
     210                 215                 220                
 Tyr Gly Pro Gly Thr Asn Arg Thr Thr Val Asn Lys Phe Leu Ser Leu
 225                 230                 235                 240
 Ala Asn Lys Arg Leu Pro Val Lys Arg Asp Cys Cys Thr Ser Phe Leu
                 245                 250                 255    
 Asn Asn Ala Trp Gly Ile Gln Lys Lys Gln Asn Ala Lys Arg Phe Lys
             260                 265                 270        
 Arg Thr Val Gly Trp Val Arg Lys Gly Trp Lys Thr Lys Glu Val Asn
         275                 280                 285            
 Pro Met Leu Lys
     290        



      <210> 678
      <211> 373
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(373)
      <223> Xaa = any amino acid or nothing 


      <400> 678
 Glu Leu Val Pro Arg Ser Leu Gly Asn Leu Leu Arg Pro Pro Met Pro
   1               5                  10                  15    
 Thr Pro His Glu Ala Glu Lys Gln Ile Thr Gly Pro Glu Glu Ala Asp
              20                  25                  30        
 Arg Pro Pro Ser Met Ser Ser His Asp Thr Ala Ser Pro Ala Ala Pro
          35                  40                  45            
 Ser Arg Ser Pro Cys Cys Leu Cys Trp Cys Xaa Cys Cys Asn Cys Ser
      50                  55                  60                
 Trp Asn Gln Gln Arg Arg Arg Ala Trp Gln Ala Ser Arg Glu Ser Lys
  65                  70                  75                  80
 Leu Gln Pro Leu Pro Ile Cys Glu Val Cys Ala Thr Pro Ser Pro Glu
                  85                  90                  95    
 Glu Val Gln Ser Trp Ala Gln Ser Phe Asp Lys Leu Met His Ser Leu
             100                 105                 110        
 Ala Gly Leu Ser Val Phe Arg Ala Phe Leu Arg Thr Glu Tyr Ser Glu
         115                 120                 125            
 Glu Asn Met Leu Phe Trp Leu Ala Cys Glu Glu Leu Lys Ala Glu Ala
     130                 135                 140                
 Asn Gln His Val Val Asp Glu Lys Ala Arg Leu Ile Tyr Glu Asp Tyr
 145                 150                 155                 160
 Val Ser Ile Leu Ser Pro Lys Glu Val Ser Leu Asp Ser Arg Val Arg
                 165                 170                 175    
 Glu Gly Ile Asn Lys Asn Met Gln Glu Pro Ser Ala His Thr Phe Asp
             180                 185                 190        
 Asp Ala Gln Leu Gln Ile Tyr Thr Leu Met His Arg Asp Ser Tyr Pro
         195                 200                 205            
 Arg Phe Leu Ser Ser Pro Thr Leu Pro Val Pro Cys Leu Leu Gln Gly
     210                 215                 220                
 Pro Phe Thr Val Leu Pro Ser Arg Gly Leu Arg Pro Pro Pro Ser Ser
 225                 230                 235                 240
 Thr Asp Pro Ala Ala Ser Tyr Gly Arg Leu Trp Val Pro Phe Arg Cys
                 245                 250                 255    
 Trp Cys Arg Gln Gly Cys Gln Gly Thr Cys Leu Ala Gly Trp Gly Pro
             260                 265                 270        
 His Pro Arg Lys Thr Val Leu Arg Pro Ser Trp Glu Val Leu Cys Leu
         275                 280                 285            
 Leu Gly Leu Pro Thr Arg Gly Gln Ala Gly Thr Pro Gly Ala Gly Arg
     290                 295                 300                
 Ala Ser Arg Cys Arg Ala Gly Gln Lys Pro Pro His Arg Pro Ala Ala
 305                 310                 315                 320
 Gly Trp Pro Ser Ala Pro Gly Trp Gly Leu Leu Arg Gly Glu Ser Lys
                 325                 330                 335    
 Gly Ser Pro Gln Glu Pro Cys Trp Thr His Glu Pro Arg Trp Gly Leu
             340                 345                 350        
 Leu His Arg Gln Pro Met Gly Pro Arg Gln Ala Phe Gly Gly Glu Gln
         355                 360                 365            
 Asn Leu Arg Ile Val
     370            



      <210> 679
      <211> 127
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(127)
      <223> Xaa = any amino acid or nothing 


      <400> 679
 Gly Gly Lys Asn Asn Xaa Asn Cys Lys Arg Asp Xaa Trp Asn Cys Lys
   1               5                  10                  15    
 Leu Xaa Xaa Cys Gln Phe Xaa Gln Leu Xaa Ala Lys Asp Ile Xaa Lys
              20                  25                  30        
 Ser Asn Arg Glu His Lys Leu Thr Asn Gly Ser Asn Gly Arg Asn Thr
          35                  40                  45            
 Glu Ser Pro Ala Ala Ile His Pro Cys Gly Asn Pro Thr Val Ile Glu
      50                  55                  60                
 Asp Ala Leu Asp Lys Ile Lys Ser Asn Asp Pro Asp Thr Thr Glu Val
  65                  70                  75                  80
 Asn Leu Asn Asn Ile Glu Asn Ile Thr Thr Gln Thr Leu Thr Ser Pro
                  85                  90                  95    
 Ser Phe Phe Pro Lys Ala Ala Thr Thr Ser Ser Ser Ser Pro Ser Phe
             100                 105                 110        
 Thr Pro Arg Glu Lys Ala His Tyr Gln Lys His Cys Arg Ser His
         115                 120                 125        



      <210> 680
      <211> 127
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(127)
      <223> Xaa = any amino acid or nothing 


      <400> 680
 Gly Gly Lys Asn Asn Xaa Asn Cys Lys Arg Asp Xaa Trp Asn Cys Lys
   1               5                  10                  15    
 Leu Xaa Xaa Cys Gln Phe Xaa Gln Leu Xaa Ala Lys Asp Ile Xaa Lys
              20                  25                  30        
 Ser Asn Arg Glu His Lys Leu Thr Asn Gly Ser Asn Gly Arg Asn Thr
          35                  40                  45            
 Glu Ser Pro Ala Ala Ile His Pro Cys Gly Asn Pro Thr Val Ile Glu
      50                  55                  60                
 Asp Ala Leu Asp Lys Ile Lys Ser Asn Asp Pro Asp Thr Thr Glu Val
  65                  70                  75                  80
 Asn Leu Asn Asn Ile Glu Asn Ile Thr Thr Gln Thr Leu Thr Ser Pro
                  85                  90                  95    
 Ser Phe Phe Pro Lys Ala Ala Thr Thr Ser Ser Ser Ser Pro Ser Phe
             100                 105                 110        
 Thr Pro Arg Glu Lys Ala His Tyr Gln Lys His Cys Arg Ser His
         115                 120                 125        



      <210> 681
      <211> 90
      <212> PRT
      <213> Homo sapiens


      <400> 681
 Thr Ser Ser Gly Arg Glu Asn Thr Val Ser Trp Leu Thr Ala Gly Glu
   1               5                  10                  15    
 Glu Asn Ala Leu Phe Leu Trp Gln Ala Ser Val Gly Ser Val Ile Lys
              20                  25                  30        
 Met Met Ala Gly Cys Gly Glu Ile Asp His Ser Ile Asn Met Leu Pro
          35                  40                  45            
 Thr Asn Arg Lys Ala Asn Glu Ser Cys Ser Asn Thr Ala Pro Ser Leu
      50                  55                  60                
 Thr Val Pro Glu Cys Ala Ile Cys Leu Gln Thr Cys Val His Pro Val
  65                  70                  75                  80
 Ser Leu Pro Cys Lys His Val Phe Cys Tyr
                  85                  90



      <210> 682
      <211> 116
      <212> PRT
      <213> Homo sapiens


      <400> 682
 Gly Met Ala Glu Glu Lys Thr Val Arg Asp Lys Glu Tyr Lys Ala Leu
   1               5                  10                  15    
 Gln Ile Lys Leu Glu Arg Leu Glu Lys Leu Cys Arg Ala Leu Gln Thr
              20                  25                  30        
 Glu Arg Asn Glu Leu Asn Glu Lys Val Glu Val Leu Lys Glu Gln Val
          35                  40                  45            
 Ser Ile Lys Ala Ala Ile Lys Ala Ala Asn Arg Asp Leu Ala Thr Pro
      50                  55                  60                
 Val Met Gln Pro Cys Thr Ala Leu Asp Ser His Lys Glu Leu Asn Thr
  65                  70                  75                  80
 Ser Ser Lys Arg Ala Leu Gly Ala His Leu Glu Ala Glu Pro Lys Ser
                  85                  90                  95    
 Gln Arg Ser Ala Val His Lys Pro Pro Ser Thr Gly Ser Ala Pro Ala
             100                 105                 110        
 Asn Arg Val Gly
         115    



      <210> 683
      <211> 159
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(159)
      <223> Xaa = any amino acid or nothing 


      <400> 683
 Gln Leu Val Gln Ala Cys Asp Pro Gly Cys Ile Ala His Leu Gln Pro
   1               5                  10                  15    
 Arg Gly Leu Arg His Ala Gly Leu Pro Gln Arg Lys Glu Gly Gln Arg
              20                  25                  30        
 Trp Leu Leu His Ala Arg Ser Arg Leu Lys Gly Gly Ala His Pro Val
          35                  40                  45            
 Glu Gly Arg Val Gln Val Xaa His His Leu Gln Val Glu Glu Val Arg
      50                  55                  60                
 Ile Leu Pro Ala Val Gly Trp Gly Arg Arg Pro Leu Pro Val Thr Glu
  65                  70                  75                  80
 Gly Leu Val Glu Val Arg Leu Ser Asp Ser Trp Ser Gln Ala Cys Asp
                  85                  90                  95    
 Pro Gly Trp Ile Ala His Tyr Ser His Val Gly Cys Gly Met Leu Gly
             100                 105                 110        
 Phe Pro Ser Glu Lys Arg Val Asn Ala Gly Phe Tyr Thr Pro Val Ala
         115                 120                 125            
 Val Xaa Arg Ala Gly Leu Thr Leu Xaa Arg Ala Val Ser Lys Phe Xaa
     130                 135                 140                
 Thr Ala Ser His Leu Ala Gln Cys Gly Thr Pro Val Gly Phe Ile
 145                 150                 155                



      <210> 684
      <211> 137
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(137)
      <223> Xaa = any amino acid or nothing 


      <400> 684
 Gly Arg Ala Gly Ser Arg Lys Trp Leu Leu Leu Thr Gly Ser Leu Ala
   1               5                  10                  15    
 Ser Thr Ser Pro Ser Leu Leu Ser Gly Gln Gly Pro Trp Ala Pro Leu
              20                  25                  30        
 Gln Arg Ala Met Lys Pro Pro Gly Gly Glu Ser Ser Asn Leu Phe Gly
          35                  40                  45            
 Phe Pro Glu Glu Ala Thr Pro Ser Ser Arg Pro Asn Arg Met Ser Ser
      50                  55                  60                
 Asn Ile Phe Gly Pro Thr Glu Glu Pro Gln Asn Ile Leu Lys Arg Thr
  65                  70                  75                  80
 Asn Pro Pro Gly Val Xaa Gly Ser Gly Ile Phe Asp Glu Ser Thr Pro
                  85                  90                  95    
 Val Gln Thr Arg Gln His Leu Asn Pro Pro Gly Gly Lys Thr Ser Asp
             100                 105                 110        
 Ile Phe Gly Ser Pro Val Thr Ala Thr Ser Arg Leu Ala His Pro Asn
         115                 120                 125            
 Lys Pro Lys Asp His Val Phe Leu Met
     130                 135        



      <210> 685
      <211> 59
      <212> PRT
      <213> Homo sapiens


      <400> 685
 Glu Ile Pro Leu Pro Thr Gly Cys Leu Asp Glu Leu Leu Lys Ala Ala
   1               5                  10                  15    
 Glu Cys Pro Ala Ala Gly Ser Val Asp Leu Gly Val Cys Leu Asp Thr
              20                  25                  30        
 Ser Ser Ser Gly Leu Asp Leu Pro Met Lys Val Val Asp Met Phe Arg
          35                  40                  45            
 Ser Cys Leu Pro Ala Cys Ala Val Asn Phe Lys
      50                  55                



      <210> 686
      <211> 33
      <212> PRT
      <213> Homo sapiens


      <400> 686
 Pro Tyr Gly Thr Trp Met Lys Leu Glu Thr Ile Ile Leu Ser Lys Leu
   1               5                  10                  15    
 Thr Gln Glu Gln Lys Thr Lys His Cys Met Phe Leu Leu Ile Ser Gly
              20                  25                  30        
 Ser
    



      <210> 687
      <211> 79
      <212> PRT
      <213> Homo sapiens


      <400> 687
 His Tyr Gln Gln Gln Arg Gln Gln Met Met Cys Leu Glu Arg His Ile
   1               5                  10                  15    
 Lys Pro Pro Lys Glu Leu Asp Thr Ala Ser Ser Asp Glu Glu Asn Lys
              20                  25                  30        
 Asp Gly Asp Phe Thr Val Phe Glu Cys Pro Gly Leu Ala Pro Thr Gly
          35                  40                  45            
 Glu Met Glu Val Arg Asn Pro Leu Leu Asp His Ser Pro Pro Ala Pro
      50                  55                  60                
 Arg Pro Arg Gly Pro Arg Gly Gly Ala Gly Pro Gly Ala Ser His
  65                  70                  75                



      <210> 688
      <211> 1380
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1380)
      <223> Xaa = any amino acid or nothing 


      <400> 688
 Met Asp Glu Ser Thr Phe Ala Gly Gly Gln Glu Tyr Gly Gly Trp Val
   1               5                  10                  15    
 Pro Glu His His Lys Ser Asn Glu Pro Lys Ser Gly His Ile Glu Lys
              20                  25                  30        
 Gly Asn Thr Asp Gln Cys Gln Glu Arg Thr Pro Gln Pro Met Ile Tyr
          35                  40                  45            
 Pro Thr Gly Glu Ile Glu Ser Thr Val Asn Ala Trp Met Leu Ser His
      50                  55                  60                
 Glu Lys Glu Gln Ser Gln Ile Leu Leu Ile Ser Asn Cys Leu Asp Ala
  65                  70                  75                  80
 Leu Lys His Arg Ser Cys Asp Tyr Gly Leu Lys Ile Ala Leu Asp Ile
                  85                  90                  95    
 Lys His Arg Leu Lys Ile Gln Pro Lys Ile Phe Ile Tyr Thr Arg Thr
             100                 105                 110        
 His Lys Tyr Ala Val Thr Leu His Met Leu Ala His Thr Ile Thr Ser
         115                 120                 125            
 Glu Arg Asp Asp Ile Glu Glu Trp Leu Asn Ala Trp Val Val Asp Gln
     130                 135                 140                
 Cys Cys Pro Pro Glu Met Ser Val Met Met Glu Met Phe Tyr Ile Tyr
 145                 150                 155                 160
 Ala Val His Tyr Gly Arg Ser Leu Leu Ser Trp Ser Gln Glu Glu Glu
                 165                 170                 175    
 Lys Glu Lys Gly Gly Arg Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
             180                 185                 190        
 Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
         195                 200                 205            
 Glu Ala Glu Glu Glu Lys Leu Gly Glu Ala Ala Val Pro Glu Gly Val
     210                 215                 220                
 Gln Leu Gly Trp Leu Thr Ala Leu Ser Leu Val Val Asn Phe His Pro
 225                 230                 235                 240
 Val Val Leu Val Ser Pro Trp Thr Trp Tyr Arg Pro Cys Ala Ile Leu
                 245                 250                 255    
 Ile Ser Leu Asp Arg Ala Arg Ala Ala Ala Gln Gly Gly Ser Arg Lys
             260                 265                 270        
 Gly Trp Ala Glu Phe Gln Ala Arg Gly Thr Glu Arg Arg Glu Gln Cys
         275                 280                 285            
 Ser Ala Ala Leu Val Arg Glu Met Glu Gln Arg Leu Leu Cys Gly Leu
     290                 295                 300                
 Leu His Pro Arg Pro Gly Cys Thr Ala Arg Ile Phe Asp Leu Ser Val
 305                 310                 315                 320
 Ala Arg Trp Leu Ala Ala Arg Trp Gly Ser Ala Cys Pro Gly Gly Ala
                 325                 330                 335    
 Ala Arg Ala Pro Arg Gly Ala Leu Ala Pro Gly Leu Arg Gln Ser Glu
             340                 345                 350        
 Ala Val Pro Ala Pro Leu Pro Pro Arg Val Ala Asp Ala Ala Gly Ala
         355                 360                 365            
 Ser Gly Lys Arg Ser Gly Arg Arg Ala Arg Ser Cys Pro Ser Pro Met
     370                 375                 380                
 Ala Arg Ala Ala Arg Val Ala Val Ala Ala Val Gly Pro His Ala Gly
 385                 390                 395                 400
 His Arg Thr Arg Arg Leu Ala Gly Arg Gly Arg Glu Gly Arg Ala Ala
                 405                 410                 415    
 Leu Ala Ala Gly Ala Gln Leu Pro Ala Ile Gly Asp Ala Arg Arg His
             420                 425                 430        
 Leu Val Ser Arg Lys Arg Pro Ser Glu Met Gly Phe Asp Pro Ala Cys
         435                 440                 445            
 Gly Arg Arg Val Phe Arg Arg Arg Gly Cys Gly Gln Ala Val Pro Pro
     450                 455                 460                
 Leu Trp Phe Pro Gly Leu Leu Leu Ala Pro Ser Trp Pro Asp Gly Arg
 465                 470                 475                 480
 Pro Gly Arg Arg Ala His Leu Lys Phe Ala Leu Leu Tyr Gly Glu Gly
                 485                 490                 495    
 Lys Phe Glu Ser Pro Glu Gly Lys Tyr Phe Ala Lys Arg Gln Ala Arg
             500                 505                 510        
 Ile Arg Gly Trp Thr Gln Glu Asp Pro Glu Ala Ser Gly Thr Ser Ser
         515                 520                 525            
 Asn Arg Ala Arg Ser Glu Pro Ser Val Leu Thr Val Ala Gly Ile Leu
     530                 535                 540                
 Gln Thr Glu Ser Arg Lys Thr Ala Lys Asp Ile Cys Lys Ile Arg Cys
 545                 550                 555                 560
 Leu Cys Glu Glu Lys Glu Asn Val Leu Asn Ile Asn Cys Glu Asn Lys
                 565                 570                 575    
 Gly Phe Thr Thr Val Ser Leu Leu Gln Pro Pro Gln Tyr Arg Ile Tyr
             580                 585                 590        
 Gln Leu Phe Leu Asn Gly Asn Leu Leu Thr Arg Leu Tyr Pro Asn Glu
         595                 600                 605            
 Phe Val Asn Tyr Ser Asn Ala Val Thr Leu His Leu Gly Asn Asn Gly
     610                 615                 620                
 Leu Gln Glu Ile Arg Thr Gly Ala Phe Ser Gly Leu Lys Thr Leu Lys
 625                 630                 635                 640
 Arg Leu His Leu Asn Asn Asn Lys Leu Glu Ile Leu Arg Glu Asp Thr
                 645                 650                 655    
 Phe Leu Gly Leu Glu Ser Leu Glu Tyr Leu Gln Ala Asp Tyr Asn Tyr
             660                 665                 670        
 Ile Ser Ala Ile Glu Ala Gly Ala Phe Ser Lys Leu Asn Lys Leu Lys
         675                 680                 685            
 Val Leu Ile Leu Asn Asp Asn Leu Leu Leu Ser Leu Pro Ser Asn Val
     690                 695                 700                
 Phe Arg Phe Val Leu Leu Thr His Leu Asp Leu Arg Gly Asn Arg Leu
 705                 710                 715                 720
 Lys Val Met Pro Phe Ala Gly Val Leu Glu His Ile Gly Gly Ile Met
                 725                 730                 735    
 Glu Ile Gln Leu Glu Glu Asn Pro Trp Asn Cys Thr Cys Asp Leu Leu
             740                 745                 750        
 Pro Leu Lys Ala Trp Leu Asp Thr Ile Thr Val Phe Val Gly Glu Ile
         755                 760                 765            
 Val Cys Glu Thr Pro Phe Arg Leu His Gly Lys Asp Val Thr Gln Leu
     770                 775                 780                
 Thr Arg Gln Asp Leu Cys Pro Arg Lys Ser Ala Ser Asp Ser Ser Gln
 785                 790                 795                 800
 Arg Gly Ser His Ala Asp Thr His Val Gln Arg Leu Ser Pro Thr Met
                 805                 810                 815    
 Asn Pro Ala Leu Asn Pro Thr Arg Ala Pro Lys Ala Ser Arg Pro Pro
             820                 825                 830        
 Lys Met Arg Asn Arg Pro Thr Pro Arg Val Thr Val Ser Lys Asp Arg
         835                 840                 845            
 Gln Ser Phe Gly Pro Ile Met Val Tyr Gln Thr Lys Ser Pro Val Pro
     850                 855                 860                
 Leu Thr Cys Pro Ser Ser Cys Val Cys Thr Ser Gln Ser Ser Asp Asn
 865                 870                 875                 880
 Gly Leu Asn Val Asn Cys Gln Glu Arg Lys Phe Thr Asn Ile Ser Asp
                 885                 890                 895    
 Leu Gln Pro Lys Pro Thr Ser Pro Lys Lys Leu Tyr Leu Thr Gly Asn
             900                 905                 910        
 Tyr Leu Gln Thr Val Tyr Lys Asn Asp Leu Leu Glu Tyr Ser Ser Leu
         915                 920                 925            
 Asp Leu Leu His Leu Gly Asn Asn Arg Ile Ala Val Ile Gln Glu Gly
     930                 935                 940                
 Ala Phe Thr Asn Leu Thr Ser Leu Arg Arg Leu Tyr Leu Asn Gly Asn
 945                 950                 955                 960
 Tyr Leu Glu Val Leu Tyr Pro Ser Met Phe Asp Gly Leu Gln Ser Leu
                 965                 970                 975    
 Gln Tyr Leu Tyr Leu Glu Tyr Asn Val Ile Lys Glu Ile Lys Pro Leu
             980                 985                 990        
 Thr Phe Asp Ala Leu Ile Asn Leu Gln Leu Leu Phe Leu Asn Asn Asn
         995                1000                1005            
 Leu Leu Arg Ser Leu Pro Asp Asn Ile Phe Gly Gly Thr Ala Leu Thr
    1010                1015                1020                
 Arg Leu Asn Leu Arg Asn Asn His Phe Ser His Leu Pro Val Lys Gly
1025                1030                1035                1040
 Val Leu Asp Gln Leu Pro Ala Phe Ile Gln Ile Asp Leu Gln Glu Asn
                1045                1050                1055    
 Pro Trp Asp Cys Thr Cys Asp Ile Met Gly Leu Lys Asp Trp Thr Glu
            1060                1065                1070        
 His Ala Asn Ser Pro Val Ile Ile Asn Glu Val Thr Cys Glu Ser Pro
        1075                1080                1085            
 Ala Lys His Ala Gly Glu Ile Leu Lys Phe Leu Gly Arg Glu Ala Ile
    1090                1095                1100                
 Cys Pro Asp Ser Pro Asn Leu Ser Asp Gly Thr Val Leu Ser Met Asn
1105                1110                1115                1120
 His Asn Thr Asp Thr Pro Arg Ser Leu Ser Val Ser Pro Ser Ser Tyr
                1125                1130                1135    
 Pro Glu Leu His Thr Glu Val Pro Leu Ser Val Leu Ile Leu Gly Leu
            1140                1145                1150        
 Leu Val Val Phe Ile Leu Ser Val Cys Phe Gly Ala Gly Leu Phe Val
        1155                1160                1165            
 Phe Val Leu Lys Arg Arg Lys Gly Val Pro Ser Val Pro Arg Asn Thr
    1170                1175                1180                
 Asn Asn Leu Asp Val Ser Ser Phe Gln Leu Gln Tyr Gly Ser Tyr Asn
1185                1190                1195                1200
 Thr Glu Thr His Asp Lys Thr Asp Gly His Val Tyr Asn Tyr Ile Pro
                1205                1210                1215    
 Pro Pro Val Gly Gln Met Cys Gln Asn Pro Ile Tyr Met Ser Arg Lys
            1220                1225                1230        
 Gly Arg Glu Thr Gln Xaa Ala Tyr Leu Pro Lys Pro Gly Lys Glu Phe
        1235                1240                1245            
 Gln Leu Leu Gly Asn Leu Glu Glu Lys Lys Glu Glu Pro Ala Thr Pro
    1250                1255                1260                
 Ala Tyr Thr Ile Ser Ala Thr Glu Leu Leu Glu Lys Gln Ala Thr Pro
1265                1270                1275                1280
 Arg Glu Pro Glu Leu Leu Tyr Xaa Asn Ile Ala Glu Pro Ser Gln Gly
                1285                1290                1295    
 Thr Ser Gln Arg Arg Pro Xaa Ser Thr Ile Thr Phe Val Pro Tyr Leu
            1300                1305                1310        
 Lys Gly Gln Cys Cys Pro Phe Pro Met Glu Phe Ser Asp Gly Gln Asn
        1315                1320                1325            
 Gln Gly Gln Asp Ser Ile Lys Thr Val Leu Tyr Gly Thr Pro Arg Lys
    1330                1335                1340                
 Cys Phe Val Gly Gln Ser Lys Pro Asn His Pro Leu Leu Gln Ala Lys
1345                1350                1355                1360
 Pro Gln Ser Glu Pro Asp Tyr Leu Glu Val Leu Glu Lys Gln Thr Ala
                1365                1370                1375    
 Ile Ser Gln Leu
            1380



      <210> 689
      <211> 140
      <212> PRT
      <213> Homo sapiens


      <400> 689
 Leu Phe Trp Ser Pro Gln Thr Gln Arg Glu Pro Thr Met Val Leu Ser
   1               5                  10                  15    
 Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly Lys Val Gly Ala
              20                  25                  30        
 His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg His Phe Asp Leu
          35                  40                  45            
 Ser His Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys Val Ala Asp
      50                  55                  60                
 Ala Leu Thr Asn Ala Val Ala His Val Asp Asp Met Pro Asn Ala Leu
  65                  70                  75                  80
 Ser Ala Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp Pro Val
                  85                  90                  95    
 Asn Phe Lys Leu Ser His Cys Leu Leu Val Thr Leu Ala Ala His Leu
             100                 105                 110        
 Pro Ala Glu Phe Thr Pro Ala Val His Ala Ser Leu Asp Lys Phe Leu
         115                 120                 125            
 Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg
     130                 135                 140



      <210> 690
      <211> 370
      <212> PRT
      <213> Homo sapiens


      <400> 690
 Met Arg Asp Asp Phe Arg Glu Ala Ala Leu Arg Pro Glu Lys Lys Ser
   1               5                  10                  15    
 Ala Lys Arg Glu Ala Glu Val Leu Lys Lys Met Gly Lys Gln Glu Lys
              20                  25                  30        
 Glu Arg Ser Lys Arg Asn Ile Ile Gly Tyr Phe Glu Gln Lys Asp Ser
          35                  40                  45            
 Asp Asn Tyr Arg Val Phe Glu Arg Val Ala Asn Ile Leu His Asp Asp
      50                  55                  60                
 Cys Ala Phe Leu Ser Ala Phe Gly Asp Val Ser Lys Pro Glu Arg Tyr
  65                  70                  75                  80
 Ser Gly Asp Asn Ile Ile Tyr Lys Pro Pro Gly His Ser Ala Pro Asp
                  85                  90                  95    
 Met Val Tyr Leu Gly Ala Met Thr Asn Phe Asp Val Thr Tyr Asn Trp
             100                 105                 110        
 Ile Gln Asp Lys Cys Val Pro Leu Val Arg Glu Ile Thr Phe Glu Asn
         115                 120                 125            
 Gly Glu Glu Pro Ser Glu Thr Ile Arg Asp Lys Ser Leu Thr His Ser
     130                 135                 140                
 Thr Glu Ala Pro Ser Gly Gly Ser Asp Phe Ile Met Gln Glu Leu Glu
 145                 150                 155                 160
 Gln Lys Glu Glu Ala Ala Gly Glu Glu Ala Asn Asp Gly Gly Ser Gly
                 165                 170                 175    
 His Ser Leu Gly Gln Glu Gly Arg Pro Arg Ala Gln Arg Thr Gln Trp
             180                 185                 190        
 Thr Gly Ala Glu Ser Pro Met Gly Lys Glu Val Leu Asp Asp Gly Arg
         195                 200                 205            
 Arg Ala Gly Pro Val Pro Ala Ala Ser Ala Cys Pro Cys His Gly Pro
     210                 215                 220                
 Gln Arg Tyr His Ala Ser Cys Arg Leu Pro Ile Leu Thr Arg Pro Gln
 225                 230                 235                 240
 Met Leu Pro Ser Ala Pro Gly Ala Glu Ser Pro Arg Pro Glu Lys Pro
                 245                 250                 255    
 Val Ser Gly Glu Asn Gly Arg Ile Ser Pro Glu Gly Leu Ile Arg Ser
             260                 265                 270        
 His Gly Val Gly Ala Ser Pro Ser Pro Arg Ser Pro Gly Val Ser Val
         275                 280                 285            
 Ser Arg Ala Ser Gly Pro Gly Gly Ser Leu Asn Arg Lys Arg Pro Ser
     290                 295                 300                
 Ile Asp Leu Ala Phe Leu Pro Thr Leu Ser Ile Trp Glu Glu Cys Glu
 305                 310                 315                 320
 Val Asp Arg Cys Trp Gly Cys Val Thr Leu Thr Gly Ser Arg Ser Leu
                 325                 330                 335    
 Lys Arg Cys Pro Gly Trp Gln Ile Pro Leu Leu Trp Leu Asp Ala Ile
             340                 345                 350        
 Gly Trp Glu Pro Arg Thr Gly Asp Trp Phe Gly Phe His Trp Glu Asn
         355                 360                 365            
 Arg Val
     370



      <210> 691
      <211> 286
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(286)
      <223> Xaa = any amino acid or nothing 


      <400> 691
 Ala Gln Glu Ile Phe Phe Lys Ser Ile Phe Ser Pro Asn Ile Ser Arg
   1               5                  10                  15    
 Gly Ser Ser Ala Gly Phe Asp Arg His Ile Thr Ile Phe Ser Pro Glu
              20                  25                  30        
 Gly Arg Leu Tyr Gln Val Glu Tyr Ala Phe Lys Ala Ile Xaa Pro Gly
          35                  40                  45            
 Gly Pro Leu Pro Ser Leu Ala Val Arg Gly Lys Asp Trp Ala Val Ile
      50                  55                  60                
 Val Thr Gln Lys Lys Ser Thr Xaa Pro Asn Tyr Leu Asp Ser Ser Thr
  65                  70                  75                  80
 Val Thr Ser Leu Phe Pro Arg Xaa Leu Lys Asn Ile Trp Cys Val Met
                  85                  90                  95    
 Thr Gly Met Thr Ala Asp Ser Arg Ser Arg Val Gln Arg Ala Arg Tyr
             100                 105                 110        
 Lys Ala Ser Tyr Trp Lys Tyr Thr Lys Tyr Gly Tyr Glu Ile Pro Val
         115                 120                 125            
 Thr Met Leu Cys Lys Gly Ile Ala Arg Tyr Cys Ser Gly Leu His Thr
     130                 135                 140                
 Arg Asn Ala Glu Asn Glu Ala Leu Leu Gly Cys Gly Met Ile Leu Ile
 145                 150                 155                 160
 Gly Tyr Ser Xaa Arg Ser Gln Gly Pro Ser Gly Tyr Ile Arg Cys Asp
                 165                 170                 175    
 Pro Ala Gly Tyr Tyr Cys Gly Phe Lys Ser Pro Thr Ala Ala Gly Ser
             180                 185                 190        
 Xaa Asn Lys Pro Glu Val Thr Pro Ala Ser Leu Glu Lys Lys Lys Xaa
         195                 200                 205            
 Arg Lys Glu Ile Trp Ile Gly Thr Phe Xaa Thr Arg Pro Val Glu Thr
     210                 215                 220                
 Ala Asn Tyr Ile Ala Cys Ser Thr Val Leu Ile Gln Leu Ile Ser Gln
 225                 230                 235                 240
 Pro Ser Glu Ile Glu Val Gly Val Val Thr Val Glu Asn Leu Lys Phe
                 245                 250                 255    
 Arg Ile Leu Thr Glu Ala Glu Ile Asp Ala His Leu Gly Cys Ser Arg
             260                 265                 270        
 Gln Arg Glu Thr Lys His Cys Leu Leu Val Tyr Arg Asp Pro
         275                 280                 285    



      <210> 692
      <211> 69
      <212> PRT
      <213> Homo sapiens


      <400> 692
 Glu Pro Lys Pro Glu Ile Thr Trp Trp Phe Glu Gly Glu Ile Leu Gln
   1               5                  10                  15    
 Asp Gly Glu Asp Tyr Gln Tyr Ile Glu Arg Gly Glu Thr Tyr Cys Leu
              20                  25                  30        
 Tyr Leu Pro Glu Thr Phe Pro Glu Asp Gly Gly Glu Tyr Met Cys Lys
          35                  40                  45            
 Ala Val Asn Asn Lys Gly Ser Ala Ala Ser Thr Cys Ile Leu Thr Ile
      50                  55                  60                
 Glu Thr Asp Asp Tyr
  65                



      <210> 693
      <211> 137
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(137)
      <223> Xaa = any amino acid or nothing 


      <400> 693
 Lys Cys Lys Lys Tyr Gln Glu Asn Ile Ser Glu Ser Ser Gln Val Cys
   1               5                  10                  15    
 Phe Asn Ile Tyr Leu Leu Ile Ile Cys Lys Leu Pro Asn Trp Ser Tyr
              20                  25                  30        
 Val Phe Ser Trp Xaa Leu Ile Tyr Ile Tyr Ile Phe Glu Met Glu Phe
          35                  40                  45            
 His Ser Ser His Arg Leu Glu Cys Ser Gly Thr Ile Ser Ala Gln Cys
      50                  55                  60                
 Ala Leu His Leu Leu Gly Ser Ser Asp Ser Pro Ala Ser Thr Ser Arg
  65                  70                  75                  80
 Val Val Gly Thr Thr Gly Val Cys His His Ala Trp Thr Val Leu Gly
                  85                  90                  95    
 Phe Phe Val Phe Leu Val Glu Thr Gly Phe Cys His Ser Asp Gln Ala
             100                 105                 110        
 Asn Leu Glu Pro Leu Thr Xaa Val Ile Arg Gln Pro Trp Pro Pro Lys
         115                 120                 125            
 Val Leu Gly Leu Phe Glu Val Arg Ser
     130                 135        



      <210> 694
      <211> 208
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(208)
      <223> Xaa = any amino acid or nothing 


      <400> 694
 Arg Leu Phe His Ser Asn Gln Thr Val Asp His Ser Gln Lys Asn Val
   1               5                  10                  15    
 Asp Ile Thr Leu Lys Gly Thr Pro Gln Xaa Ser Cys Lys Gly Pro Arg
              20                  25                  30        
 Gly Asn Leu Cys Gly Arg Asp Phe Ile His Ile Asn Val Glu Pro Gln
          35                  40                  45            
 Pro Phe Leu Glu Lys Xaa Lys Lys Arg Leu Pro Gly Leu Thr Lys Trp
      50                  55                  60                
 Trp Gly Asn Arg Lys Gly Asn Trp Pro Thr Arg Ser Gly Leu Phe Gly
  65                  70                  75                  80
 Ser His Val Gln Asp His Asp Pro Arg Gly Val Thr Thr Gly Ala Ser
                  85                  90                  95    
 Val Thr Lys Met Arg Val Leu Cys Met Pro His Leu Pro Pro Ile Gln
             100                 105                 110        
 Pro Leu Val Tyr Pro Gln Glu Asn Gly Ser Ser Leu Leu Lys Ser Arg
         115                 120                 125            
 Asn Phe Leu Gly Xaa Lys Asn Tyr Ile Gly Arg Val Arg Met Glu Thr
     130                 135                 140                
 Arg Val Leu Leu Cys Ser Val Ser Gln Gly Gln Lys Asp Glu Leu Ile
 145                 150                 155                 160
 Leu Lys Gly Asn Asp Ile Glu Leu Val Ser Asn Ser Ala Ala Leu Ile
                 165                 170                 175    
 Gln Gln Ala Pro Pro Val Lys Asn Lys Asp Ile Arg Lys Phe Leu Asp
             180                 185                 190        
 Gly Ile Xaa Val Ser Glu Lys Gly Thr Val Gln Pro Gly Leu Ile Glu
         195                 200                 205            





      <210> 695
      <211> 475
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(475)
      <223> Xaa = any amino acid or nothing 


      <400> 695
 Gly Ser Ala His Ile Arg Ser Pro Gly Ser Pro Ala Arg His Arg Ala
   1               5                  10                  15    
 Ser Leu Pro Ala Pro Arg Arg Pro Gln Pro Ala Ser Lys Asp Gln Cys
              20                  25                  30        
 Gly Met Ser Ala Pro Gly Ala Tyr Thr Gly Val Asn Phe Glu Gly Ala
          35                  40                  45            
 Leu Phe Ser Gly Tyr Ala Pro Asp Gly Gly Leu Phe Met Pro Glu Glu
      50                  55                  60                
 Leu Pro Gln Leu Asp Arg Glu Thr Leu Cys Gln Trp Ser Thr Leu Ser
  65                  70                  75                  80
 Tyr Pro Gly Leu Val Lys Glu Leu Cys Ala Leu Phe Ile Gly Ser Glu
                  85                  90                  95    
 Leu Leu Pro Lys Asp Glu Leu Asn Asp Leu Ile Asp Arg Ala Phe Ser
             100                 105                 110        
 Arg Phe Arg His Arg Glu Val Val His Leu Ser Arg Leu Arg Asn Gly
         115                 120                 125            
 Leu Asn Leu Leu Glu Leu Leu His Gly Val Thr Tyr Ala Phe Lys Asp
     130                 135                 140                
 Leu Ser Leu Ser Cys Thr Thr Gln Phe Leu Gln Tyr Phe Leu Glu Lys
 145                 150                 155                 160
 Arg Glu Lys His Val Thr Val Val Val Gly Thr Ser Gly Asp Thr Gly
                 165                 170                 175    
 Ser Ala Ala Ile Glu Ser Val Gln Gly Ala Lys Asn Met Asp Ile Ile
             180                 185                 190        
 Val Leu Leu Pro Lys Gly His Cys Thr Lys Ile Gln Glu Leu Gln Met
         195                 200                 205            
 Thr Thr Val Leu Glu Glu Asn Val Gln Cys Leu Gly Val Glu Gly Asn
     210                 215                 220                
 Ser Asp Xaa Ala Ser Ile Glu Pro Ile Lys Thr Val Phe Ala Asp Val
 225                 230                 235                 240
 Ala Phe Val Lys Lys His Asn Leu Met Ser Leu Asn Ser Ile Asn Trp
                 245                 250                 255    
 Ser Arg Val Leu Val Gln Met Ala His His Phe Phe Ala Tyr Phe Gln
             260                 265                 270        
 Cys Thr Pro Ser Leu Asp Thr His Pro Leu Pro Leu Val Glu Val Val
         275                 280                 285            
 Val Pro Thr Gly Ala Ala Gly Asn Leu Ala Ala Gly Tyr Ile Ala Gln
     290                 295                 300                
 Lys Ile Gly Leu Pro Ile Arg Leu Val Val Ala Val Asn Arg Asn Asp
 305                 310                 315                 320
 Ile Ile His Arg Thr Val Gln Gln Gly Asp Phe Ser Leu Ser Glu Ala
                 325                 330                 335    
 Val Lys Ser Thr Leu Ala Ser Ala Met Asp Ile Gln Val Pro Tyr Asn
             340                 345                 350        
 Met Glu Arg Val Phe Trp Leu Leu Ser Gly Ser Asp Ser Gln Val Thr
         355                 360                 365            
 Arg Ser Leu Met Glu Gln Phe Glu Arg Thr Gln Ser Val Asn Leu Pro
     370                 375                 380                
 Lys Glu Leu His Ser Lys Leu Ser Glu Ala Val Thr Ser Val Ser Val
 385                 390                 395                 400
 Ser Asp Glu Ala Ile Thr Gln Thr Met Gly Arg Cys Trp Asp Glu Asn
                 405                 410                 415    
 Gln Tyr Leu Leu Cys Pro His Ser Ala Val Ala Val Asn Tyr His Tyr
             420                 425                 430        
 Gln Gln Ile Asp Arg Gln Gln Pro Arg Tyr Arg Gln Trp Val Ala Trp
         435                 440                 445            
 Ala Thr Glu Gly Pro Phe Glu Phe Gln Gly Pro Ser Ser Ser Pro Ser
     450                 455                 460                
 Ser Gly Arg Asp Arg Thr Thr Lys Lys Trp Leu
 465                 470                 475



      <210> 696
      <211> 426
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(426)
      <223> Xaa = any amino acid or nothing 


      <400> 696
 Met Arg Ala Val Ser Leu Leu Val Leu Val Leu Gly Val Thr Met Ser
   1               5                  10                  15    
 Tyr Val Met Pro Trp Pro Gln Thr Glu Asn Tyr Thr Ile Tyr Phe Pro
              20                  25                  30        
 Gly Ser Glu Ala Phe Lys Leu Gly Arg Ala Ile Ser Ser Leu Pro Ser
          35                  40                  45            
 Ile Gln Tyr Pro Gly Ser Ser Ala Tyr Arg Trp Pro Val Met Glu Leu
      50                  55                  60                
 Leu Ser Leu Tyr Asn Tyr Ala Arg Arg Ala Leu Met Gly Asn Leu Ala
  65                  70                  75                  80
 Asn Val Ile Pro Trp Gly Trp Ser Glu Lys Met Thr Ile Glu Tyr Leu
                  85                  90                  95    
 Asn Pro Gly Thr Gly Glu Leu Leu Asn Asn Ser Arg Gly Asp Ala Pro
             100                 105                 110        
 His Ser Glu His Val His His Arg Arg Val Pro Arg Ala Gly Asn Ala
         115                 120                 125            
 Ala Ala Ser Asp Cys Cys Val Gly Ala Ala Ala Pro Pro Gly Gln Asp
     130                 135                 140                
 Arg Arg Gly Gly Ala Ser Gly Val Gly Lys Thr Gly Ser Arg Cys Pro
 145                 150                 155                 160
 Leu Gly Val Gly Leu Ala Val Val Tyr Ala Thr Arg Leu Leu Pro Gln
                 165                 170                 175    
 Thr Gly Glu Thr Arg Ile Lys Asn Gly Gln Ala Ala Phe Trp Gly His
             180                 185                 190        
 Arg His Arg Arg His Gln Asn Phe Gly Val Phe Glu Pro Leu Gln Cys
         195                 200                 205            
 Leu Ala Gln Lys Gly Glu Leu Val Lys Leu Ala Pro Leu Gly Gly Leu
     210                 215                 220                
 Glu Ala Leu Val Val Arg Phe Leu Thr Lys Arg Phe Ile Gly Asp Tyr
 225                 230                 235                 240
 Glu Arg Asn Ala Gly Asn Leu Tyr Thr Arg Gln Val Gln Ile Glu Gly
                 245                 250                 255    
 Glu Thr Leu Ala Leu Gln Val Gln Asp Thr Pro Gly Phe Arg Ser Met
             260                 265                 270        
 Arg Thr Ala Xaa Ala Ala Val Asn Ser Leu Ile Xaa Cys Ile Gly Cys
         275                 280                 285            
 Ala His Ala Gly Gly Met Gly Tyr Ser Ile Thr Asp Tyr Lys Ser Tyr
     290                 295                 300                
 Glu Leu Ile Ser Gln Leu His Gln His Val Gln Lys Leu His Leu Gly
 305                 310                 315                 320
 Thr Arg Leu Pro Val Val Val Ala Ala Asn Lys Ala Asp Leu Leu His
                 325                 330                 335    
 Ile Lys Gln Val Asp Pro Gln Leu Gly Leu Gln Leu Ala Ser Met Leu
             340                 345                 350        
 Gly Cys Ser Phe Tyr Glu Glu Ser Val Ser Glu Asn Tyr Asn Asp Val
         355                 360                 365            
 Tyr Ser Ala Phe His Val Leu Cys Lys Glu Val Ser His Lys Gln Gln
     370                 375                 380                
 Pro Ser Ser Thr Pro Glu Lys Arg Arg Thr Ser Leu Ile Pro Arg Pro
 385                 390                 395                 400
 Lys Ser Pro Asn Met Gln Asp Leu Lys Arg Arg Phe Lys Gln Ala Leu
                 405                 410                 415    
 Ser Ala Lys Val Arg Thr Val Thr Ser Val
             420                 425    



      <210> 697
      <211> 66
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(66)
      <223> Xaa = any amino acid or nothing 


      <400> 697
 Met Gln Leu Xaa Xaa Val Val Pro Pro Pro Leu Leu Xaa Pro Gly Pro
   1               5                  10                  15    
 Leu Gln Phe Leu Ile Gln Arg Ser Arg Gly His His Ala Pro Pro Ala
              20                  25                  30        
 Xaa Ala Ser Ser Arg Pro Gly Gln Asp Asp Xaa Xaa Xaa Thr Cys Gly
          35                  40                  45            
 Ala Xaa Leu Leu Arg Pro Arg Gly His Phe Leu Arg Ala Ala Xaa Val
      50                  55                  60                
 Pro Asn
  65    



      <210> 698
      <211> 1222
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1222)
      <223> Xaa = any amino acid or nothing 


      <400> 698
 Met Gly Cys Thr Pro Ser His Ser Asp Leu Val Asn Ser Val Ala Lys
   1               5                  10                  15    
 Ser Gly Ile Gln Phe Leu Lys Lys Pro Lys Ala Ile Arg Pro Gly Cys
              20                  25                  30        
 Gln Gly Gly Ser Glu Arg Gly Ser Ile Pro Leu Leu Val Lys Asn Ser
          35                  40                  45            
 Thr Cys Tyr Asp Ala Gly Glu Gly Leu Ala Glu Glu Gln Pro Ser Pro
      50                  55                  60                
 Arg Arg Asn Gln Thr Thr Ala Lys Gly Leu Cys Gln Leu Met Gly Asp
  65                  70                  75                  80
 Pro Ala Ser Gly Lys Arg Lys Asp Met Glu Gly Leu Ile Pro Gly Thr
                  85                  90                  95    
 Lys Thr Ser Ser Ser Gln Leu Asn Lys Ser Gln Ser His Met Ala Lys
             100                 105                 110        
 Asp Ile Pro Phe Lys Thr Gln Gly Ser His Gly Ser Gln Gly Ala Asp
         115                 120                 125            
 Phe Ser Gly Asp Glu Ser Glu Glu Ser Ser Thr Gln Asp Thr Ser Lys
     130                 135                 140                
 Trp Lys Arg Thr Ala Lys Cys His Thr Ser Ser Thr Gln Ser His Cys
 145                 150                 155                 160
 Tyr Gln Thr Ile His Pro Ala His Glu Pro Glu Gly Lys Val Asp Phe
                 165                 170                 175    
 Pro Glu Pro Leu Val Lys Ala His Gln Gln Ala Tyr Thr Tyr Leu His
             180                 185                 190        
 Ser Ser Leu Ser Lys Tyr Glu Ala Ile Leu Cys Ile Ile His Gln Ala
         195                 200                 205            
 Thr Gln Thr Arg Glu Leu Leu Gln Pro Met Val Ser Phe Leu Leu Leu
     210                 215                 220                
 Cys Phe Glu Glu Ile Ser Gln Leu Leu Gly Glu Ile Ser Lys Asp Gly
 225                 230                 235                 240
 Glu Val Leu Leu Gln Glu Val Arg Glu Asp Leu Ala Trp Pro Leu Lys
                 245                 250                 255    
 Lys Arg Glu Pro Gln Glu Gln Pro Asn Leu Leu Gln Gln Leu Leu Gln
             260                 265                 270        
 Tyr Thr Val Ser Lys Leu Gln Val Leu Asn Gly Thr Val Ala Ser Leu
         275                 280                 285            
 Thr Gly Ser Phe Leu Glu Gly Ser Ser Ser Tyr Leu His Ser Thr Ala
     290                 295                 300                
 Thr His Leu Glu Asn Lys Leu Ser Thr Lys Arg Asn Val Asp Glu Arg
 305                 310                 315                 320
 Leu Leu Arg Ala Leu Arg Gln Leu Glu Ser Leu Ala Ser Gly Cys Gly
                 325                 330                 335    
 Asp Pro Gly Val Gln Gly Leu Pro Leu Cys Ser Glu Asp Ser Gly Ile
             340                 345                 350        
 Gly Ala Asp Asn Glu Ser Val Gln Ser Val Asp Lys Leu Gly Lys Gln
         355                 360                 365            
 Thr Ser Trp Asp Leu Ala Pro Glu Pro Glu Glu Trp Lys Ser Val Thr
     370                 375                 380                
 Ser Pro His Thr Glu Ala Arg Gln Ser Gly His Thr Trp Gln Gln Ser
 385                 390                 395                 400
 Pro Phe Cys Leu Gly Ser Gly Arg Pro Gln Asp Cys Leu Leu Ser Gly
                 405                 410                 415    
 Ala Pro Met Ala Lys Val Gln Pro Arg Ala Gln Asp Glu Ala Arg Ser
             420                 425                 430        
 Pro Cys Leu Ser Ser Thr Ser Pro Glu Asn Ile Thr Ser Pro Pro Leu
         435                 440                 445            
 Lys Leu Gly Thr Ser Thr Pro Cys Asp Ser Phe Gly Ile Gly Val Ser
     450                 455                 460                
 Val Glu Pro His Leu Ser Lys Thr Ser Arg Pro Met Asp Ala Ser Ser
 465                 470                 475                 480
 Leu Ser Asp Ser Glu Asp Ser Ser Pro Glu Glu Glu Glu Glu Asp Lys
                 485                 490                 495    
 Met Ser Ser Met Ser Leu Cys Ala Trp Gln Glu Lys Thr Pro His Ser
             500                 505                 510        
 Arg Pro Gln Ser Ser Pro Ala Asp Arg Glu Ser Pro Phe Gln Ala Arg
         515                 520                 525            
 Thr Arg Arg Leu Arg Ser Leu Gln Ala Gln Glu Met Ile Leu Lys Met
     530                 535                 540                
 Lys Glu Ser Ile Ser Glu Arg Ile Lys Phe Val Pro Val Pro Cys Gly
 545                 550                 555                 560
 His Gln Asp Trp Ser Glu Glu Glu Glu Gly Arg Thr Val Val Pro Pro
                 565                 570                 575    
 Arg Pro Ser Thr Val Ser Gly Ser Arg Arg Ala Pro Glu Arg Gln Thr
             580                 585                 590        
 Arg Ser Gln Ser Glu Ser Cys Leu Gln Ser His Val Glu Asp Pro Thr
         595                 600                 605            
 Phe Gln Glu Leu Arg Arg Val Gln Arg Asp Leu Ser Gln Lys Leu Glu
     610                 615                 620                
 Ala Phe Tyr Ala Leu Gly Ala Lys Gly Gln Gly Gln Ser Gln Glu Gln
 625                 630                 635                 640
 Ile Leu Gln Pro Arg Ala Ala Ala Val Trp Pro Asn Gly Thr Cys Arg
                 645                 650                 655    
 Val Ser Pro Ser Asn Thr Thr Ser Arg Leu Lys Ala Ser Leu Thr Lys
             660                 665                 670        
 Asn Phe Ser Ile Leu Pro Ser Gln Asp Lys Ser Ile Leu Gln Lys Cys
         675                 680                 685            
 Asn Pro His Pro Glu Asp Glu Gln Gly Lys Ala Gly Lys Leu Pro Asn
     690                 695                 700                
 Ala Ile Pro Ser Gly Glu Val Ser Glu Ala Ala Lys Ala Thr Asp Trp
 705                 710                 715                 720
 Asn Val Arg Gly Cys Pro Thr Arg Thr Ser Val Lys Lys Leu Ile Glu
                 725                 730                 735    
 Thr Phe Ser Pro Thr Glu Ser Leu Arg Met Leu Gly Asp Ser Lys Asp
             740                 745                 750        
 Ala Gly Ala Ser Pro Cys Leu Arg Asn Cys Ile Met Pro Pro Arg Phe
         755                 760                 765            
 Pro Lys Tyr Thr Gly Leu Ala Pro Leu Tyr Pro Lys Pro Gln Ile Ser
     770                 775                 780                
 Pro Ala Ser Gly Arg Glu Ser Pro Gln Asn Gly His Arg Leu Glu Ala
 785                 790                 795                 800
 Leu Ser Thr Tyr Leu Ser Pro Ser Ala Xaa Ser Arg Ser Ser Gln Glu
                 805                 810                 815    
 Xaa Gly Ala Gln Leu Xaa Asn Gly Gly Glu Pro Arg Ala Pro Pro Ser
             820                 825                 830        
 Pro Pro Met Glu Val Leu Met Asp Lys Ser Phe Ala Ser Arg Ser Pro
         835                 840                 845            
 Gln Lys Ala Ala Ser Pro Gln Arg Thr Pro Pro Arg Lys Pro Arg Ser
     850                 855                 860                
 Gln Gly Arg Glu Arg Leu Ala Pro Pro Gly Glu His Gly Leu Pro Gln
 865                 870                 875                 880
 Ser Xaa Gly Pro Leu Xaa Ala Pro Trp Thr Cys Cys Pro Ala Arg Ala
                 885                 890                 895    
 Pro Pro Ala Xaa Pro Ser Leu Thr Ala Gln Gly Gln Gly Val Ala Gly
             900                 905                 910        
 Ala Ala Ala Ser Pro Gly Ser Gln Pro Trp Thr Xaa Ala Ala His Gln
         915                 920                 925            
 Pro Pro Ala Lys Ala Pro Arg Xaa Arg Val Gly Leu Gly Val Arg Gln
     930                 935                 940                
 Arg Arg Pro Pro Ala Ser Thr Gly Ser Pro Gly Arg Pro Ser Pro Gly
 945                 950                 955                 960
 Thr Thr Pro Ala Pro Ile Trp Thr Lys Gln Asp Leu Arg Val Gln Pro
                 965                 970                 975    
 Gly Gln Thr Lys Ala Glu Pro Lys Arg Ser Pro Pro Val Gly Arg Lys
             980                 985                 990        
 Ala Ser Pro Thr Arg Thr His Trp Val Pro Gln Ala Asp Lys Arg Arg
         995                1000                1005            
 Arg Ser Leu Pro Ser Ser Tyr Arg Pro Ala Gln Pro Ser Pro Ser Ala
    1010                1015                1020                
 Val Gln Thr Pro Pro Ser Pro Pro Val Ser Pro Arg Val Leu Ser Pro
1025                1030                1035                1040
 Pro Thr Thr Lys Arg Arg Thr Ser Pro Pro His Gln Pro Lys Leu Pro
                1045                1050                1055    
 Asn Pro Pro Pro Glu Ser Ala Pro Ala Gln Cys Lys Val Pro Ser Pro
            1060                1065                1070        
 Pro Thr Gln His Pro Glu Ala Ser Pro Pro Phe Ser Ile Pro Ser Pro
        1075                1080                1085            
 Ser Pro Pro Met Ser Pro Ser Gln Glu His Lys Glu Thr Arg Asp Ser
    1090                1095                1100                
 Glu Asp Ser Gln Ala Val Ile Ala Lys Val Ser Gly Asn Thr His Ser
1105                1110                1115                1120
 Ile Phe Cys Pro Ala Thr Ser Ser Leu Phe Glu Ala Lys Pro Pro Leu
                1125                1130                1135    
 Ser Thr Ala His Pro Leu Thr Pro Pro Ser Leu Pro Pro Glu Ala Gly
            1140                1145                1150        
 Gly Pro Leu Gly Asn Pro Ala Glu Cys Trp Lys Asn Ser Ser Gly Pro
        1155                1160                1165            
 Trp Leu Arg Ala Asp Ser Gln Arg Arg Ala Ala Leu Cys Ala Leu Asn
    1170                1175                1180                
 Pro Leu Pro Phe Leu Arg Arg Thr Ala Ser Asp Arg Gln Pro Gly Gly
1185                1190                1195                1200
 Arg Pro Gln Pro Pro Thr Leu Asp Pro Thr Ser Thr Ser Tyr Glu Ser
                1205                1210                1215    
 Gln Leu Gly Gln Asn Arg
            1220        



      <210> 699
      <211> 131
      <212> PRT
      <213> Homo sapiens


      <400> 699
 Cys Glu Gly Asn Ser Thr Cys Ser Glu Asn Glu Val Cys Val Arg Pro
   1               5                  10                  15    
 Gly Glu Cys Arg Cys Arg His Gly Tyr Phe Gly Ala Asn Cys Asp Thr
              20                  25                  30        
 Lys Cys Pro Arg Gln Phe Trp Gly Pro Asp Cys Lys Glu Leu Cys Ser
          35                  40                  45            
 Cys His Pro His Gly Gln Cys Glu Asp Val Thr Gly Gln Cys Thr Cys
      50                  55                  60                
 His Ala Arg Arg Trp Gly Ala Arg Cys Glu His Ala Cys Gln Cys Gln
  65                  70                  75                  80
 His Gly Thr Cys His Pro Arg Ser Gly Ala Cys Arg Cys Glu Pro Gly
                  85                  90                  95    
 Trp Trp Gly Ala Gln Cys Ala Ser Ala Cys Tyr Cys Ser Ala Thr Ser
             100                 105                 110        
 Arg Cys Asp Pro Gln Thr Gly Ala Cys Leu Cys His Ala Gly Trp Trp
         115                 120                 125            
 Gly Arg Ser
     130    



      <210> 700
      <211> 283
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(283)
      <223> Xaa = any amino acid or nothing 


      <400> 700
 Leu Asn Leu Ser Cys Ala Asp Val Val Trp His Gln Met Asp Glu Asn
   1               5                  10                  15    
 Leu Leu Ala Thr Ala Ala Thr Asn Gly Val Val Val Thr Trp Asn Leu
              20                  25                  30        
 Gly Arg Pro Ser Arg Asn Lys Gln Asp Gln Leu Phe Thr Glu His Lys
          35                  40                  45            
 Arg Thr Val Asn Lys Val Cys Phe His Pro Thr Glu Ala His Val Leu
      50                  55                  60                
 Leu Ser Gly Ser Gln Asp Gly Phe Met Lys Cys Phe Asp Leu Arg Arg
  65                  70                  75                  80
 Lys Asp Ser Val Ser Thr Phe Phe Gly Gln Ser Glu Ser Val Arg Asp
                  85                  90                  95    
 Val Gln Phe Ser Ile Arg Asp Tyr Phe Thr Phe Ala Ser Thr Phe Xaa
             100                 105                 110        
 Glu Arg Ala Met Leu Gln Leu Trp Asp Ile Arg Arg Pro Asp Arg Cys
         115                 120                 125            
 Glu Arg Met Phe Thr Ala His Asn Gly Pro Val Phe Cys Cys Asp Trp
     130                 135                 140                
 His Pro Glu Asp Arg Gly Trp Leu Ala Thr Gly Gly Arg Asp Lys Met
 145                 150                 155                 160
 Val Lys Val Trp Asp Met Thr Thr His Arg Ala Lys Glu Met His Cys
                 165                 170                 175    
 Val Gln Thr Ile Ala Ser Val Ala Arg Val Glu Trp Arg Pro Glu Cys
             180                 185                 190        
 Arg His His Leu Ala Thr Cys Ser Met Met Val Asp Tyr Asn Ile Tyr
         195                 200                 205            
 Val Trp Asp Val Arg Arg Pro Tyr Val Pro Ala Ala Cys Leu Arg His
     210                 215                 220                
 Arg Thr Ser His Gly Ile Ala Trp Arg Thr Pro Arg Pro Ser Ser Val
 225                 230                 235                 240
 Phe Gly Gln Thr Val Val Ala Ser Leu Phe Gly Ala Ala Ala Gly Arg
                 245                 250                 255    
 Ala Pro Gly Pro Cys Thr Pro Trp Asp Cys Ser Arg Lys Asn Pro Gly
             260                 265                 270        
 Arg Trp Gly Ser Tyr Leu Asp Gly Pro Pro Phe
         275                 280            



      <210> 701
      <211> 283
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(283)
      <223> Xaa = any amino acid or nothing 


      <400> 701
 Leu Asn Leu Ser Cys Ala Asp Val Val Trp His Gln Met Asp Glu Asn
   1               5                  10                  15    
 Leu Leu Ala Thr Ala Ala Thr Asn Gly Val Val Val Thr Trp Asn Leu
              20                  25                  30        
 Gly Arg Pro Ser Arg Asn Lys Gln Asp Gln Leu Phe Thr Glu His Lys
          35                  40                  45            
 Arg Thr Val Asn Lys Val Cys Phe His Pro Thr Glu Ala His Val Leu
      50                  55                  60                
 Leu Ser Gly Ser Gln Asp Gly Phe Met Lys Cys Phe Asp Leu Arg Arg
  65                  70                  75                  80
 Lys Asp Ser Val Ser Thr Phe Phe Gly Gln Ser Glu Ser Val Arg Asp
                  85                  90                  95    
 Val Gln Phe Ser Ile Arg Asp Tyr Phe Thr Phe Ala Ser Thr Phe Xaa
             100                 105                 110        
 Glu Arg Ala Met Leu Gln Leu Trp Asp Ile Arg Arg Pro Asp Arg Cys
         115                 120                 125            
 Glu Arg Met Phe Thr Ala His Asn Gly Pro Val Phe Cys Cys Asp Trp
     130                 135                 140                
 His Pro Glu Asp Arg Gly Trp Leu Ala Thr Gly Gly Arg Asp Lys Met
 145                 150                 155                 160
 Val Lys Val Trp Asp Met Thr Thr His Arg Ala Lys Glu Met His Cys
                 165                 170                 175    
 Val Gln Thr Ile Ala Ser Val Ala Arg Val Glu Trp Arg Pro Glu Cys
             180                 185                 190        
 Arg His His Leu Ala Thr Cys Ser Met Met Val Asp Tyr Asn Ile Tyr
         195                 200                 205            
 Val Trp Asp Val Arg Arg Pro Tyr Val Pro Ala Ala Cys Leu Arg His
     210                 215                 220                
 Arg Thr Ser His Gly Ile Ala Trp Arg Thr Pro Arg Pro Ser Ser Val
 225                 230                 235                 240
 Phe Gly Gln Thr Val Val Ala Ser Leu Phe Gly Ala Ala Ala Gly Arg
                 245                 250                 255    
 Ala Pro Gly Pro Cys Thr Pro Trp Asp Cys Ser Arg Lys Asn Pro Gly
             260                 265                 270        
 Arg Trp Gly Ser Tyr Leu Asp Gly Pro Pro Phe
         275                 280            



      <210> 702
      <211> 63
      <212> PRT
      <213> Homo sapiens


      <400> 702
 Asn Gly Pro Met Cys Phe Val Lys Gln Leu Glu Ile Pro Gln Tyr Gly
   1               5                  10                  15    
 Tyr Arg Asn Asn Val Pro Thr Thr Thr Pro Arg Ser Asn Leu Ala Lys
              20                  25                  30        
 Glu Leu Glu Lys Tyr Ser Lys Thr Ser Phe Glu Tyr Thr Ile Asn Asp
          35                  40                  45            
 Asn His Thr Tyr Gly Gly Leu Gly Cys Met Arg Pro Arg Leu Val
      50                  55                  60            



      <210> 703
      <211> 189
      <212> PRT
      <213> Homo sapiens


      <400> 703
 Met Pro Gln Gln Val Gln Asn His Gly Asn Arg Asn Ser Leu Ser Asp
   1               5                  10                  15    
 His Ser Ala Ile Lys Leu Glu Leu Arg Ile Lys Lys Leu Thr Gln Asn
              20                  25                  30        
 His Thr Ile Thr Trp Lys Leu Asn Asn Leu Leu Leu Asn Asp Tyr Trp
          35                  40                  45            
 Ile Asn Asn Glu Ile Lys Val Glu Ile Asn Lys Phe Phe Asp Thr Asn
      50                  55                  60                
 Lys Asn Lys Asp Thr Thr Tyr Gln Asn Leu Trp Asp Thr Gly Phe Pro
  65                  70                  75                  80
 Ile Ser Lys Pro Asp Gly Leu Ser Gln Leu Glu Gln Asp Leu Gln Val
                  85                  90                  95    
 Phe Asp Leu Glu Thr Lys Thr Arg Glu Val Leu Arg Asp Asp Phe Ser
             100                 105                 110        
 Glu Phe Arg Gln Ile Thr Ile Ser Lys Glu Ala Phe Thr Ser Glu Lys
         115                 120                 125            
 Asn Asn Glu Cys Asn Lys Pro Glu Lys Ser Phe Ser Leu Asp Ser Thr
     130                 135                 140                
 Ile Asp Ala Asp Gln Lys Val Leu Arg Ile Gln Asn Thr Asp Asp Asn
 145                 150                 155                 160
 Asp Lys Asn Asp Met Ser Phe Ser Gln Asn Ser Ala Ser Gly Lys His
                 165                 170                 175    
 Glu His Ile Asn Leu Thr Gln Asp Phe Gln Ser Ser Ile
             180                 185                



      <210> 704
      <211> 137
      <212> PRT
      <213> Homo sapiens


      <400> 704
 Ile Leu Val Leu Glu Ser Leu Ala Phe Lys Glu Ala Trp Gly Asn Gly
   1               5                  10                  15    
 Gly Lys Val Arg Ile Asp Ser Asp Arg Ile Leu Arg Trp Ala Glu Leu
              20                  25                  30        
 Thr Ser Gly Arg Gly His Ser Val Leu Ile Tyr Leu Thr Cys Val Gln
          35                  40                  45            
 Asp Gly Gln Ala Met Leu Trp Asp Leu Asn Glu Gly Lys His Leu Tyr
      50                  55                  60                
 Thr Leu Asp Gly Gly Asp Ile Ile Asn Ala Leu Cys Phe Ser Pro Asn
  65                  70                  75                  80
 Arg Tyr Trp Leu Cys Ala Ala Thr Gly Pro Ser Ile Lys Ile Trp Asp
                  85                  90                  95    
 Leu Glu Gly Lys Ile Ile Val Asp Glu Leu Lys Gln Glu Val Ser Val
             100                 105                 110        
 Gln Gln Gln Ala Asp His Pro Arg His Leu Leu Pro Val Cys Asp Ala
         115                 120                 125            
 Lys Leu Cys Cys Ala Thr Arg His Leu
     130                 135        



      <210> 705
      <211> 151
      <212> PRT
      <213> Homo sapiens


      <400> 705
 Arg Ala Gly Gln Glu Phe Gln Ala His Lys Ala Ile Leu Ala Ala Arg
   1               5                  10                  15    
 Ser Pro Val Phe Ser Ala Met Phe Glu His Glu Met Glu Glu Ser Lys
              20                  25                  30        
 Lys Asn Arg Val Glu Ile Asn Asp Val Glu Pro Glu Val Phe Lys Glu
          35                  40                  45            
 Met Met Cys Phe Ile Tyr Thr Gly Lys Ala Pro Asn Leu Asp Lys Met
      50                  55                  60                
 Ala Asp Asp Leu Leu Ala Ala Ala Asp Lys Tyr Ala Leu Glu Arg Leu
  65                  70                  75                  80
 Lys Val Met Cys Glu Asp Ala Leu Cys Ser Asn Leu Ser Val Glu Asn
                  85                  90                  95    
 Ala Ala Glu Ile Leu Ile Leu Ala Asp Leu His Ser Ala Asp Gln Leu
             100                 105                 110        
 Lys Thr Gln Ala Val Asp Phe Ile Asn Tyr Leu Gly Ala Gly Pro Arg
         115                 120                 125            
 Ile Ser Gln Arg Trp Tyr Phe Gly Asp Thr Cys Leu His Leu Thr Glu
     130                 135                 140                
 Gln Asn Lys Ser Ser Gly Ala
 145                 150    



      <210> 706
      <211> 113
      <212> PRT
      <213> Homo sapiens


      <400> 706
 Arg Glu Thr Gly Leu Pro Ala Leu Gly Thr Cys Ala Val Pro Leu Ala
   1               5                  10                  15    
 Arg Ala Ala Pro Ile Leu Gln Arg Leu Gln Gln Ser Pro Arg Thr Ser
              20                  25                  30        
 Leu Lys Ala Arg Pro Lys Thr Arg Ile Thr Gly Ala Leu Pro Met Asp
          35                  40                  45            
 His Thr Glu Gly Ser Pro Ala Glu Glu Pro Pro Ala His Ala Pro Ser
      50                  55                  60                
 Pro Gly Lys Phe Gly Glu Arg Pro Pro Pro Lys Arg Leu Thr Arg Glu
  65                  70                  75                  80
 Ala Met Arg Asn Tyr Leu Lys Glu Arg Gly Asp Gln Thr Val Leu Ile
                  85                  90                  95    
 Leu His Ala Lys Val Ala Gln Lys Ser Tyr Gly Asn Glu Lys Arg Phe
             100                 105                 110        
 Phe
    



      <210> 707
      <211> 99
      <212> PRT
      <213> Homo sapiens


      <400> 707
 Lys His Phe Lys Met Arg Lys Ile Asp Leu Cys Leu Ser Ser Glu Gly
   1               5                  10                  15    
 Ser Glu Val Ile Leu Ala Thr Ser Ser Asp Glu Lys His Pro Pro Glu
              20                  25                  30        
 Asn Ile Ile Asp Gly Asn Pro Glu Thr Phe Trp Thr Thr Thr Gly Met
          35                  40                  45            
 Phe Pro Gln Glu Phe Ile Ile Cys Phe His Lys His Val Arg Ile Glu
      50                  55                  60                
 Arg Leu Val Ile Gln Ser Tyr Phe Asp Leu Val His Thr Glu Gly Gln
  65                  70                  75                  80
 Leu Gln Asn Glu Glu Ile Val Ala Pro Ile Pro Asn Tyr Gly Ser Thr
                  85                  90                  95    
 Gly His Leu
            



      <210> 708
      <211> 99
      <212> PRT
      <213> Homo sapiens


      <400> 708
 Lys His Phe Lys Met Arg Lys Ile Asp Leu Cys Leu Ser Ser Glu Gly
   1               5                  10                  15    
 Ser Glu Val Ile Leu Ala Thr Ser Ser Asp Glu Lys His Pro Pro Glu
              20                  25                  30        
 Asn Ile Ile Asp Gly Asn Pro Glu Thr Phe Trp Thr Thr Thr Gly Met
          35                  40                  45            
 Phe Pro Gln Glu Phe Ile Ile Cys Phe His Lys His Val Arg Ile Glu
      50                  55                  60                
 Arg Leu Val Ile Gln Ser Tyr Phe Asp Leu Val His Thr Glu Gly Gln
  65                  70                  75                  80
 Leu Gln Asn Glu Glu Ile Val Ala Pro Ile Pro Asn Tyr Gly Ser Thr
                  85                  90                  95    
 Gly His Leu
            



      <210> 709
      <211> 92
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(92)
      <223> Xaa = any amino acid or nothing 


      <400> 709
 Val Phe Ser Cys Gly Gly Cys Trp Ser Val Thr Val Lys Met Leu Arg
   1               5                  10                  15    
 Asn Leu Leu Ala Leu Arg Gln Ile Gly Gln Arg Thr Ile Ser Thr Ala
              20                  25                  30        
 Ser Arg Arg His Phe Lys Asn Lys Val Pro Glu Lys Gln Lys Leu Phe
          35                  40                  45            
 Gln Gly Thr Ala Tyr Ala Ile Tyr Glu Leu Ala Val Ala Ser Phe Pro
      50                  55                  60                
 Asn Glu Ala Gly Val Thr Ser Val Ile Pro Ala Ile Ala Trp Phe Ser
  65                  70                  75                  80
 Phe Ile Gln Leu Ser Met Asp Gln Xaa Ser Asp Lys
                  85                  90        



      <210> 710
      <211> 192
      <212> PRT
      <213> Homo sapiens


      <400> 710
 Ala Pro Ala Glu Phe Arg Thr Ser Gly Glu Ala Ala Gly Ser Gly Glu
   1               5                  10                  15    
 Arg Arg Glu Gln Pro Ser Val Thr Glu Arg Val Pro Thr Ala Leu Gly
              20                  25                  30        
 Val Pro Arg Met Cys Val Ala Gln Val Leu Thr Ala His Leu Leu Pro
          35                  40                  45            
 Pro Arg Gln Ala Leu Gly Ser Leu Cys Ser Pro Trp Ala Ala Pro Arg
      50                  55                  60                
 Val Gly Pro Leu Pro Pro Ala Pro Ala Met Val Arg Ile Ser Lys Pro
  65                  70                  75                  80
 Lys Thr Phe Gln Ala Tyr Leu Asp Asp Cys His Arg Arg Tyr Ser Cys
                  85                  90                  95    
 Ala His Cys Arg Ala His Leu Ala Asn His Asp Asp Leu Ile Ser Lys
             100                 105                 110        
 Ser Phe Gln Gly Ser Gln Gly Arg Ala Tyr Leu Phe Asn Ser Val Val
         115                 120                 125            
 Asn Val Gly Cys Gly Pro Ala Glu Glu Arg Val Leu Leu Thr Gly Leu
     130                 135                 140                
 His Ala Val Ala Asp Ile His Cys Glu Asn Cys Lys Thr Thr Leu Gly
 145                 150                 155                 160
 Trp Lys Tyr Glu Gln Ala Phe Glu Ser Ser Gln Lys Tyr Lys Glu Gly
                 165                 170                 175    
 Lys Tyr Ile Ile Glu Leu Asn His Met Ile Lys Asp Asn Gly Trp Asp
             180                 185                 190        





      <210> 711
      <211> 34
      <212> PRT
      <213> Homo sapiens


      <400> 711
 Leu Pro Ser Gly Ile Leu Val Gln Thr Ala Ala Arg Thr Val Met Met
   1               5                  10                  15    
 Ala Pro Asp Ala Pro Ser Asp Gly Pro Tyr Leu Pro Val Ala Thr Leu
              20                  25                  30        
 Pro Thr
        



      <210> 712
      <211> 200
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(200)
      <223> Xaa = any amino acid or nothing 


      <400> 712
 Ser Pro Ala Ala Ser Gly Gly Phe Arg Ala Gly Pro Arg Asn Gln Asp
   1               5                  10                  15    
 Pro Ser Arg Ala Leu Ala Glu Leu Trp Pro Thr Lys Ala Val Ser Val
              20                  25                  30        
 Leu Lys Gly Asp Gly Pro Val Gln Gly Ile Ile Asn Phe Glu Gln Lys
          35                  40                  45            
 Glu Ser Asn Gly Pro Ser Glu Gly Trp Gly Lys His Leu Lys Gly Leu
      50                  55                  60                
 Thr Glu Gly Leu His Gly Phe His Val His Glu Phe Gly Asp Asn Thr
  65                  70                  75                  80
 Ala Gly Cys Thr Ser Ala Gly Pro His Phe Ile Pro Leu Ser Arg Lys
                  85                  90                  95    
 His Gly Gly Pro Lys Asp Glu Glu Arg His Val Glu Asp Leu Gly Gln
             100                 105                 110        
 Cys Xaa Leu Leu Asp Lys Asp Gly Val Gly Pro Met Cys Leu Leu Lys
         115                 120                 125            
 Asp Ser Val Ile Phe Thr Leu Gln Gly Asp His Leu His His Leu Gly
     130                 135                 140                
 Arg Thr Leu Val Val Pro Trp Lys Lys Pro Asp Asp Leu Gly Gln Arg
 145                 150                 155                 160
 Val Gly Asn Glu Glu Ser Ser Lys Thr Gly Asn Ala Gly Lys Phe Val
                 165                 170                 175    
 Trp Ala Cys Gly Val Asn Leu Gly Ser Ala Pro Asn Lys His Ser Pro
             180                 185                 190        
 Trp Asp Val Val Leu Arg Pro Pro
         195                 200



      <210> 713
      <211> 118
      <212> PRT
      <213> Homo sapiens


      <400> 713
 Gly Thr Arg Trp Arg Pro Gly Ser Met Ala Gly Leu Glu Leu Leu Ser
   1               5                  10                  15    
 Asp Gln Gly Tyr Arg Val Asp Gly Arg Arg Ala Gly Glu Leu Arg Lys
              20                  25                  30        
 Ile Gln Ala Arg Met Gly Val Phe Ala Gln Ala Asp Gly Ser Ala Tyr
          35                  40                  45            
 Ile Glu Gln Gly Asn Thr Lys Ala Leu Ala Val Val Tyr Gly Pro His
      50                  55                  60                
 Glu Ala Ser Gly Arg Ala Gly Trp Gly Ile Val Trp Pro Trp Glu Leu
  65                  70                  75                  80
 Arg Gly Ser Arg Ala Glu Arg Trp Leu Gly Asp Leu Arg Gly Asn Gly
                  85                  90                  95    
 Arg Arg Ala Ser Val Tyr Thr Ala Asp Ala Gln His Arg Ile Ser Leu
             100                 105                 110        
 Gly Val Asn Ala Ser Pro
         115            



      <210> 714
      <211> 262
      <212> PRT
      <213> Homo sapiens


      <400> 714
 Glu Asp Thr Gly Gly Ile His Met Glu Glu Ala Pro Glu Thr Tyr Ile
   1               5                  10                  15    
 Pro Ser Arg Ala Val Ser Leu Phe Phe Asn Trp Lys Gln Glu Phe Arg
              20                  25                  30        
 Thr Leu Glu Val Thr Leu Arg Asp Phe Ser Lys Leu Asn Lys Gln Asp
          35                  40                  45            
 Ile Arg Tyr Leu Gly Lys Ile Phe Ser Ser Ala Thr Ser Leu Arg Leu
      50                  55                  60                
 Gln Ile Lys Arg Cys Ala Gly Val Ala Gly Ser Leu Ser Leu Val Leu
  65                  70                  75                  80
 Ser Thr Cys Lys Asn Ile Tyr Ser Leu Met Val Glu Ala Ser Pro Leu
                  85                  90                  95    
 Thr Ile Glu Asp Glu Arg His Ile Thr Ser Val Thr Asn Leu Lys Thr
             100                 105                 110        
 Leu Ser Ile His Asp Leu Gln Asn Gln Arg Leu Pro Gly Gly Leu Thr
         115                 120                 125            
 Asp Ser Leu Gly Asn Leu Lys Asn Leu Thr Lys Leu Ile Met Asp Asn
     130                 135                 140                
 Ile Lys Met Asn Glu Glu Asp Ala Ile Lys Leu Ala Glu Gly Leu Lys
 145                 150                 155                 160
 Asn Leu Lys Lys Met Cys Leu Phe His Leu Thr His Leu Ser Asp Ile
                 165                 170                 175    
 Gly Glu Gly Met Asp Tyr Ile Val Lys Ser Leu Ser Ser Glu Pro Cys
             180                 185                 190        
 Asp Leu Glu Glu Ile Gln Leu Val Ser Cys Cys Leu Ser Ala Asn Ala
         195                 200                 205            
 Val Lys Ile Leu Ala Gln Asn Leu His Asn Leu Val Lys Leu Ser Ile
     210                 215                 220                
 Leu Asp Leu Ser Glu Asn Tyr Leu Glu Lys Asp Gly Asn Glu Ala Leu
 225                 230                 235                 240
 His Glu Leu Ile Asp Arg Met Asn Val Leu Lys Gln Leu Asn Ala Leu
                 245                 250                 255    
 Glu Leu Pro Leu Gly Leu
             260        



      <210> 715
      <211> 232
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(232)
      <223> Xaa = any amino acid or nothing 


      <400> 715
 Asp Ser Ser Asn Leu Val Pro Phe Ser Gly Phe Thr Ser Asn Ser Ser
   1               5                  10                  15    
 Ser Leu Ala Val Ser Thr Thr Ser Thr Val Thr Ser Tyr Asn Glu Ile
              20                  25                  30        
 Leu Lys Leu Ser Val Ile Lys Val Arg Ile Asn Phe Phe Gln Thr Pro
          35                  40                  45            
 Val Asn Val Ala Ile Leu Ile Ser Phe His Glu Thr Ser Val Phe Leu
      50                  55                  60                
 Leu Ala Ser Arg Met Leu Asn Ser Phe Gln Lys Ile Phe Ser Leu Pro
  65                  70                  75                  80
 Arg Phe Trp Ile Trp Ala Lys Arg Pro Gly Ile Leu Pro Asn Ile Cys
                  85                  90                  95    
 Asn Ala Gln Glu Ser Ser Ser Pro Thr Lys Asp Xaa Gln Arg Lys Trp
             100                 105                 110        
 Phe Leu Glu Met Arg Ser Thr Pro Gly Glu Asp Ala Ala Asn Asn Val
         115                 120                 125            
 Glu Met Thr Thr Lys Asp Leu Asn Tyr Asp Arg Asn Leu Val Asp Lys
     130                 135                 140                
 Ala Val Val Gly Phe Glu Arg Thr Asp Ser Asn Phe Glu Arg Ser Cys
 145                 150                 155                 160
 Thr Val Gly Asn Ser Ile Ala Xaa Tyr Arg Glu Ile Val His Gly Lys
                 165                 170                 175    
 Lys Ser Thr Trp Met Gln Gln Thr Ser Leu Leu Ser Tyr Phe Lys Lys
             180                 185                 190        
 Leu Pro Gln Pro Leu His Pro Ser Ala Thr Thr Thr Leu Val Tyr Xaa
         195                 200                 205            
 Lys Pro Ser Ile Ser Arg Gln Asp Ser Pro Pro Thr Lys Arg Leu Xaa
     210                 215                 220                
 Leu Thr Asp Gly Ser Asp Asp His
 225                 230        



      <210> 716
      <211> 988
      <212> PRT
      <213> Homo sapiens


      <400> 716
 Met Arg Arg Asp Pro Thr Pro Pro Arg Gly Leu Pro Arg Gln Arg Pro
   1               5                  10                  15    
 Thr Pro Ser Pro Arg Thr Arg Ser Arg Gly His Gln Ser Gln Arg Pro
              20                  25                  30        
 Lys Ala Lys Ser Glu Pro Gln Pro Ala Pro Ala Ala Thr Pro Gly Gly
          35                  40                  45            
 Arg Arg Ala Trp Glu Pro Arg Ala Gln Ala Gly Cys Pro Pro Pro Pro
      50                  55                  60                
 Arg Ala Ala Ser Pro Arg Arg Leu Val Gln Gly Glu Arg Pro Glu Ser
  65                  70                  75                  80
 Gly Asn Arg Ser Arg Gln Ala Ala Tyr Pro Arg Arg Ala Ser Arg Ala
                  85                  90                  95    
 Arg Thr Cys Thr Thr Arg Leu Pro Pro Thr Leu Arg Gln Arg Ala Leu
             100                 105                 110        
 Thr Gln Arg Pro Cys Ser Val Pro Arg Thr Asn Arg Lys Leu Arg Arg
         115                 120                 125            
 Gly Pro Gly Pro Ile Thr Leu Arg Arg Pro Glu Ser Cys Ser Arg Pro
     130                 135                 140                
 Ala Phe Ala Thr Glu Ala His Asp Ala Gln Ala Leu Pro Arg Pro Pro
 145                 150                 155                 160
 Gly Val Ile Ala Arg Gln Ser Ala Met His Arg Ala Leu Ala Ala Leu
                 165                 170                 175    
 Lys Asn Lys Pro Leu Asn His Val His Lys Val Val Lys Glu Arg Leu
             180                 185                 190        
 Cys Pro Trp Leu Cys Ser Arg Gln Pro Glu Pro Phe Gly Val Lys Phe
         195                 200                 205            
 His His Ala His Cys Lys Lys Phe His Ser Lys Asn Gly Asn Asp Leu
     210                 215                 220                
 His Pro Leu Gly Gly Pro Val Phe Ser Gln Val Ser Asp Cys Asp Arg
 225                 230                 235                 240
 Leu Glu Gln Asn Val Lys Asn Glu Glu Ser Gln Met Phe Tyr Arg Arg
                 245                 250                 255    
 Leu Ser Asn Leu Thr Ser Ser Glu Glu Val Leu Ser Phe Ile Ser Thr
             260                 265                 270        
 Met Glu Thr Leu Pro Asp Thr Met Ala Ala Gly Ala Leu Gln Arg Ile
         275                 280                 285            
 Cys Glu Val Glu Lys Lys Asp Gly Asp Gln Gly Leu Pro Lys Glu Ile
     290                 295                 300                
 Leu Glu Asn Ser Ile Phe Gln Ala Leu Cys Phe Gln Phe Glu Lys Glu
 305                 310                 315                 320
 Pro Ser Gln Leu Ser Asn Thr Ser Leu Val Thr Ala Leu Gln Ala Leu
                 325                 330                 335    
 Ile Leu Leu His Val Asp Pro Gln Ser Ser Leu Leu Leu Asn Leu Val
             340                 345                 350        
 Ala Glu Cys Gln Asn Arg Leu Arg Lys Gly Gly Met Glu Val Arg Asn
         355                 360                 365            
 Leu Cys Ile Leu Gly Glu Ser Leu Ile Thr Leu His Ser Ser Gly Cys
     370                 375                 380                
 Val Thr Leu Glu Leu Ile Ile Asn Gln Leu Gln Gly Glu Lys Leu Glu
 385                 390                 395                 400
 Thr Phe Thr Pro Glu Asp Ile Val Ala Leu Tyr Arg Ile Leu Gln Ala
                 405                 410                 415    
 Cys Thr Glu Lys Val Asp Glu His Gln Thr Phe Leu Asn Lys Ile Asn
             420                 425                 430        
 Asn Phe Ser Leu Ser Ile Val Ser Asn Leu Ser Pro Lys Leu Ile Ser
         435                 440                 445            
 Gln Met Leu Thr Ala Leu Val Val Leu Asp Gln Ser Gln Ala Phe Pro
     450                 455                 460                
 Leu Ile Ile Lys Leu Gly Lys Tyr Val Val Arg His Val Pro His Phe
 465                 470                 475                 480
 Thr Asn Glu Glu Leu Arg Arg Val Leu Glu Ala Phe Ile Tyr Phe Gly
                 485                 490                 495    
 His His Asp Thr Phe Phe Thr Lys Ala Leu Glu His Arg Val Ala Ala
             500                 505                 510        
 Val Cys Leu Thr Leu Asp Pro Glu Val Val Cys Arg Val Met Glu Tyr
         515                 520                 525            
 Cys Ser Arg Glu Leu Ile Leu Ser Lys Pro Ile Leu Asn Ala Val Ala
     530                 535                 540                
 Glu Thr Phe Val Cys Gln Thr Glu Lys Phe Ser Pro Arg Gln Ile Ser
 545                 550                 555                 560
 Ala Leu Met Glu Pro Phe Gly Lys Leu Asn Tyr Leu Pro Pro Asn Ala
                 565                 570                 575    
 Ser Ala Leu Phe Arg Lys Leu Glu Asn Val Leu Phe Thr His Phe Asn
             580                 585                 590        
 Tyr Phe Pro Pro Lys Ser Leu Leu Lys Leu Leu His Ser Cys Ser Leu
         595                 600                 605            
 Asn Glu Cys His Pro Val Asn Phe Leu Ala Lys Ile Phe Lys Pro Leu
     610                 615                 620                
 Phe Leu Gln Arg Leu Gln Asp Val Glu Ile Lys Leu Asp Glu Glu Gly
 625                 630                 635                 640
 Phe Val Leu Pro Ser Thr Ala Asn Glu Asp Ile His Lys Arg Ile Ala
                 645                 650                 655    
 Leu Cys Ile Asp Gly Pro Lys Arg Phe Cys Ser Asn Ser Lys His Leu
             660                 665                 670        
 Leu Gly Lys Glu Ala Ile Lys Gln Arg His Leu Gln Leu Leu Gly Tyr
         675                 680                 685            
 Gln Val Val Gln Pro Leu Leu Ile Leu Ser His Leu Ala Leu Pro Tyr
     690                 695                 700                
 Pro Leu His Val Arg Ile Gln Gln Thr Val Leu Ile Thr Leu Gly Thr
 705                 710                 715                 720
 Leu Asn Ala Pro Ala Leu Gly Pro Asn Arg Lys Glu Pro Leu Pro Leu
                 725                 730                 735    
 Arg Gly Leu Lys Gln Gly Ser Ser Asp Thr Lys Glu Ala Arg His Ser
             740                 745                 750        
 Arg Gly Asp Cys Glu Ala Leu Gly Gln Trp Ser Tyr Lys Phe Arg Ser
         755                 760                 765            
 Gln Gln Leu Lys Glu Arg Ala Ser Thr Glu Gln Thr Gly Ala Ser Asp
     770                 775                 780                
 Glu Thr Cys Leu His Val Asp Pro Leu Gly Gln Phe Phe Lys Ala Ser
 785                 790                 795                 800
 Pro Gly Pro Ser Glu Arg Phe Met Thr Ile His Gln Leu Pro Ser Ala
                 805                 810                 815    
 Val Thr Trp Ala Gly Ala Leu Asp Gly Gly Gly Met Glu Asp Asp Glu
             820                 825                 830        
 Glu Glu Thr Thr Ala Ser Thr Leu Arg Gly Lys Pro Arg Pro Pro Pro
         835                 840                 845            
 Val Ser Ala Gln Ser Ala Phe Ser Tyr Ile Pro Pro Arg Arg Leu Asp
     850                 855                 860                
 Pro Lys Glu His Ser Tyr Tyr Tyr Arg Pro Ala Arg Val Lys Lys Val
 865                 870                 875                 880
 Phe Ala Ser Pro Leu Leu Ser Ala Met Ile Thr Gly Ile Ile Ser Leu
                 885                 890                 895    
 Tyr Asp Cys Ile Phe Lys Arg Arg Leu Asp Tyr Asp Gln Lys Leu His
             900                 905                 910        
 Arg Asp Asp Arg Glu His Ala Lys Ser Leu Gly Leu His Val Asn Glu
         915                 920                 925            
 Glu Glu Gln Glu Arg Pro Val Gly Val Leu Thr Ser Ser Val Tyr Gly
     930                 935                 940                
 Lys Arg Ile Asn Gln Pro Ile Glu Pro Leu Asn Arg Asp Phe Gly Arg
 945                 950                 955                 960
 Ala Asn His Val Gln Ala Asp Phe Tyr Arg Lys Asn Asp Ile Pro Ser
                 965                 970                 975    
 Leu Lys Glu Pro Gly Phe Gly His Ile Ala Pro Ser
             980                 985            



      <210> 717
      <211> 121
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(121)
      <223> Xaa = any amino acid or nothing 


      <400> 717
 Gly Asp Ser Gly Gly Ser Pro Trp Pro Asp Glu Lys Pro Lys Glu Gly
   1               5                  10                  15    
 Val Lys Thr Glu Asn Asn Asp His Ile Asn Leu Lys Val Ala Gly Gln
              20                  25                  30        
 Asp Gly Ser Val Val Gln Phe Lys Ile Lys Arg His Thr Pro Leu Ser
          35                  40                  45            
 Lys Leu Met Lys Ala Tyr Cys Glu Arg Gln Gly Leu Ser Met Arg Gln
      50                  55                  60                
 Ile Arg Phe Pro Ile Xaa Pro Gly Asn Pro Ile Asn Glu Thr Asp Thr
  65                  70                  75                  80
 Pro Ala Thr Val Gly Lys Trp Lys Asp Glu Asp Thr Ile Asp Val Phe
                  85                  90                  95    
 Gln Gln Ala Arg Pro Gly Gly Val Tyr Leu Lys Lys Gly Thr Cys Phe
             100                 105                 110        
 Leu Tyr Ser Gln Asn Ser Val Ser Phe
         115                 120    



      <210> 718
      <211> 375
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(375)
      <223> Xaa = any amino acid or nothing 


      <400> 718
 Glu Asn Ser Pro Leu Pro Lys Ala Val Arg Gly Val Arg Pro Arg Thr
   1               5                  10                  15    
 Ser Leu Ile Gly Arg Thr Ser Pro Leu Val Thr Leu Phe Cys Leu Ser
              20                  25                  30        
 Trp Gln Arg Ile Lys Ala Ala Ala Ala Ala Leu Gly Thr Ala Leu Pro
          35                  40                  45            
 Arg Leu Cys Tyr Pro Trp Leu Gly Gly Pro Ala Lys Gln Leu Leu Arg
      50                  55                  60                
 Ala Ala Pro Gly Arg Leu Ala Ala Lys Glu Ala Ser Val Leu Cys Arg
  65                  70                  75                  80
 Leu Gln Gly Gly Asp Gln Lys Ala Glu Ser Thr Ala Gly Asp Ala Gly
                  85                  90                  95    
 Ala Ser Ala Val His Gln Arg Ser Thr Asp Thr Leu Ser Ser Ser Val
             100                 105                 110        
 Met Ala Ser Ile Ile Ala Arg Val Gly Asn Ser Arg Arg Leu Asn Ala
         115                 120                 125            
 Pro Leu Pro Pro Trp Ala His Ser Met Leu Arg Ser Leu Gly Arg Ser
     130                 135                 140                
 Leu Gly Pro Ile Met Ala Ser Met Ala Asp Arg Asn Met Lys Leu Phe
 145                 150                 155                 160
 Ser Gly Arg Val Val Pro Ala Gln Gly Glu Glu Thr Phe Glu Asn Trp
                 165                 170                 175    
 Leu Thr Gln Val Asn Gly Val Leu Pro Asp Trp Asn Met Ser Glu Glu
             180                 185                 190        
 Glu Lys Leu Lys Arg Leu Met Lys Thr Leu Arg Gly Pro Ala Arg Glu
         195                 200                 205            
 Val Met Arg Val Leu Gln Ala Thr Asn Pro Asn Leu Ser Val Glu Ile
     210                 215                 220                
 Phe Leu Arg Ala Met Lys Leu Gly Val Phe Gly Gly Val Xaa Lys Gln
 225                 230                 235                 240
 Phe Xaa Leu Ser Pro Trp Val Asn Phe Phe Asn Thr Leu Thr Lys Leu
                 245                 250                 255    
 Lys Gly Glu Lys Ala Ser Leu Tyr Val Ile Arg Leu Glu Val Gln Leu
             260                 265                 270        
 Gln Asn Ala Ile Gln Ala Gly Ile Ile Ala Arg Lys Met Gln Thr Gly
         275                 280                 285            
 Thr Arg Leu Gln Gln Leu Leu Leu Gly Gly Glu Leu Ser Arg Asp Leu
     290                 295                 300                
 Arg Leu Arg Leu Lys Asp Phe Leu Arg Met Tyr Ala Asn Glu Gln Glu
 305                 310                 315                 320
 Arg Leu Pro Asn Phe Leu Glu Leu Ile Arg Met Val Arg Glu Glu Glu
                 325                 330                 335    
 Asp Trp Asp Asp Ala Phe Ile Lys Arg Lys Arg Pro Lys Arg Ser Glu
             340                 345                 350        
 Ser Met Val Glu Arg Ala Val Ser Pro Val Ala Phe Gln Gly Ser Pro
         355                 360                 365            
 Pro Ile Val Ile Gly Ser Ala
     370                 375



      <210> 719
      <211> 152
      <212> PRT
      <213> Homo sapiens


      <400> 719
 Asn Trp Ala Gly Thr Gly His Ser Leu Gln Gln Val Thr Gly His Asp
   1               5                  10                  15    
 His Tyr Asn Ala Asp Leu Lys Pro Ile Asp Gly Phe Asn Gly Arg Phe
              20                  25                  30        
 Gly Tyr Arg Arg Asn Thr Pro Ala Leu Arg Gln Ser Thr Ser Val Phe
          35                  40                  45            
 Gly Glu Arg Pro Asp Arg Met Val Ser Val Leu Asn Arg Lys Leu Ser
      50                  55                  60                
 Ala Glu Glu Leu Glu Arg Lys Arg Gln Glu Met Met Glu Asn Ala Lys
  65                  70                  75                  80
 Trp Arg Glu Glu Glu Arg Leu Asn Ile Leu Lys Arg His Ala Lys Asp
                  85                  90                  95    
 Glu Glu Arg Glu Gln Arg Leu Glu Lys Leu Asp Ser Arg Asp Gly Lys
             100                 105                 110        
 Phe Ile His Arg Met Lys Leu Glu Ser Ala Ser Thr Ser Ser Leu Glu
         115                 120                 125            
 Asp Arg Val Lys Arg Asn Ile Tyr Ser Leu Gln Arg Thr Ser Val Ala
     130                 135                 140                
 Leu Glu Lys Asn Phe Met Lys Arg
 145                 150        



      <210> 720
      <211> 152
      <212> PRT
      <213> Homo sapiens


      <400> 720
 Asn Trp Ala Gly Thr Gly His Ser Leu Gln Gln Val Thr Gly His Asp
   1               5                  10                  15    
 His Tyr Asn Ala Asp Leu Lys Pro Ile Asp Gly Phe Asn Gly Arg Phe
              20                  25                  30        
 Gly Tyr Arg Arg Asn Thr Pro Ala Leu Arg Gln Ser Thr Ser Val Phe
          35                  40                  45            
 Gly Glu Arg Pro Asp Arg Met Val Ser Val Leu Asn Arg Lys Leu Ser
      50                  55                  60                
 Ala Glu Glu Leu Glu Arg Lys Arg Gln Glu Met Met Glu Asn Ala Lys
  65                  70                  75                  80
 Trp Arg Glu Glu Glu Arg Leu Asn Ile Leu Lys Arg His Ala Lys Asp
                  85                  90                  95    
 Glu Glu Arg Glu Gln Arg Leu Glu Lys Leu Asp Ser Arg Asp Gly Lys
             100                 105                 110        
 Phe Ile His Arg Met Lys Leu Glu Ser Ala Ser Thr Ser Ser Leu Glu
         115                 120                 125            
 Asp Arg Val Lys Arg Asn Ile Tyr Ser Leu Gln Arg Thr Ser Val Ala
     130                 135                 140                
 Leu Glu Lys Asn Phe Met Lys Arg
 145                 150        



      <210> 721
      <211> 96
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(96)
      <223> Xaa = any amino acid or nothing 


      <400> 721
 Asn Val Asp Leu Leu Ile Pro Asn Ser Ser Ile Thr Leu Leu Ser Asp
   1               5                  10                  15    
 Arg Pro Ala Ser Ile Leu Leu Arg Thr Phe Ile Phe Ser Ser Lys Phe
              20                  25                  30        
 Ser Val Val Tyr Phe Pro Leu Leu Phe Ile Leu Asn Leu Thr Leu Asn
          35                  40                  45            
 His Gln Gln Glu Lys Thr Lys Gly Lys Ala Leu Met Asn Trp Gln Lys
      50                  55                  60                
 Lys Lys Pro Thr Phe Phe Lys Gln Asn Leu Ala Glu Ser Pro Lys Arg
  65                  70                  75                  80
 His Gly His Cys Ile Gly Gly Xaa Trp Thr Glu Gly Ala Asn His Asp
                  85                  90                  95    





      <210> 722
      <211> 299
      <212> PRT
      <213> Homo sapiens


      <400> 722
 Met Gly His Val Ser Ser Asp Asp Gly His Ser Asp Glu Asp Glu Leu
   1               5                  10                  15    
 Arg Lys Ser Leu Ser Glu Leu Val Asp Asp Lys Phe Gly Thr Gly Thr
              20                  25                  30        
 Lys Lys Val Thr Arg Ile Leu Asp Gly Gly Asn Pro Phe Leu Asp Val
          35                  40                  45            
 Pro Gln Ala Leu Ser Ala Thr Thr Tyr Lys His Gly Val Leu Thr Arg
      50                  55                  60                
 Lys Thr His Ala Asp Met Asp Gly Lys Arg Thr Pro Arg Gly Arg Arg
  65                  70                  75                  80
 Gly Trp Lys Lys Phe Tyr Ala Val Leu Lys Gly Thr Ile Leu Tyr Leu
                  85                  90                  95    
 Gln Lys Val Arg Asp Cys Pro Arg Asp Leu Thr His Pro Gly Ala Ser
             100                 105                 110        
 Asp Tyr Ser Lys Lys Ser Asn Val Leu Lys Leu Lys Thr Ala Asp Trp
         115                 120                 125            
 Arg Val Phe Leu Phe Gln Ala Pro Ser Lys Glu Glu Met Leu Ser Trp
     130                 135                 140                
 Ile Leu Arg Ile Asn Leu Val Ala Ala Ile Phe Ser Ala Pro Ala Phe
 145                 150                 155                 160
 Pro Ala Ala Val Ser Ser Met Lys Lys Phe Cys Arg Pro Leu Leu Pro
                 165                 170                 175    
 Ser Cys Thr Thr Arg Leu Cys Gln Glu Glu Gln Leu Arg Ser His Glu
             180                 185                 190        
 Asn Lys Leu Arg Gln Leu Thr Ala Glu Leu Ala Glu His Arg Cys His
         195                 200                 205            
 Pro Val Glu Arg Gly Ile Lys Ser Lys Glu Ala Glu Glu Tyr Arg Leu
     210                 215                 220                
 Lys Glu His Tyr Leu Thr Phe Glu Lys Ser Arg Tyr Glu Thr Tyr Ile
 225                 230                 235                 240
 His Leu Leu Ala Met Lys Ile Lys Val Gly Ser Asp Asp Leu Glu Arg
                 245                 250                 255    
 Ile Glu Ala Arg Leu Ala Thr Leu Glu Gly Asp Asp Pro Ser Leu Arg
             260                 265                 270        
 Lys Thr His Ser Ser Pro Ala Leu Ser Gln Gly His Val Thr Gly Ser
         275                 280                 285            
 Lys Thr Thr Lys Asp Ala Thr Gly Pro Asp Thr
     290                 295                



      <210> 723
      <211> 246
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(246)
      <223> Xaa = any amino acid or nothing 


      <400> 723
 Ala Arg Ser Cys Arg Ala Ala Leu Ser Glu Ala Ser Ala Gly Arg Pro
   1               5                  10                  15    
 Leu Pro Pro Phe Pro Gly Arg Ala Lys Glu Thr Cys Arg Ala Ala Ala
              20                  25                  30        
 Met Glu Ala Ile Trp Leu Tyr Gln Phe Arg Leu Ile Val Ile Gly Asp
          35                  40                  45            
 Ser Thr Val Gly Lys Ser Cys Leu Ile Arg Arg Phe Thr Glu Gly Arg
      50                  55                  60                
 Phe Ala Gln Val Ser Asp Pro Thr Val Gly Val Asp Phe Phe Ser Arg
  65                  70                  75                  80
 Leu Val Glu Ile Glu Pro Gly Lys Arg Ile Lys Leu Gln Ile Trp Asp
                  85                  90                  95    
 Thr Ala Gly Gln Glu Arg Phe Arg Ser Ile Thr Arg Ala Tyr Tyr Arg
             100                 105                 110        
 Asn Ser Val Gly Gly Leu Leu Leu Ser Asp Ile Thr Asn Arg Ser Ser
         115                 120                 125            
 Phe Gln Asn Val His Ala Ser Trp Gln Glu Pro Lys Leu His Val Gln
     130                 135                 140                
 Pro Tyr Gln Ile Val Leu Val Leu Val Gly His Lys Cys Asp Leu Asp
 145                 150                 155                 160
 Thr Gln Arg Gln Val Thr Arg His Glu Ala Glu Lys Leu Ala Ala Asp
                 165                 170                 175    
 Thr Ala Met Lys Tyr Ile Glu Thr Ser Ala Arg Asp Ala Ile Asn Val
             180                 185                 190        
 Glu Glu Ser Pro Ser Gln Thr Xaa Pro Arg Asp Ile Tyr Glu Leu Val
         195                 200                 205            
 Lys Arg Gly Glu Ile Thr Ile Gln Glu Gly Trp Glu Gly Val Lys Ser
     210                 215                 220                
 Gly Phe Val Pro Asn Val Val His Ser Ser Glu Glu Val Val Lys Ser
 225                 230                 235                 240
 Glu Arg Arg Cys Leu Cys
                 245    



      <210> 724
      <211> 47
      <212> PRT
      <213> Homo sapiens


      <400> 724
 Leu Lys Asn Lys Lys Asn Ile Tyr Phe Cys Lys Leu Ser Glu Cys Arg
   1               5                  10                  15    
 Asp Val Leu Tyr Asn Pro Asn Thr Val Gln Ile Ser Ser Pro Lys Arg
              20                  25                  30        
 Asn Glu Gln Gly Lys Thr Glu Lys Glu Leu Tyr Gln Met Cys Ser
          35                  40                  45        



      <210> 725
      <211> 114
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(114)
      <223> Xaa = any amino acid or nothing 


      <400> 725
 Pro Arg Ser Val Pro Ser Arg Phe Ser Gly Gly Arg Thr His Glu Gly
   1               5                  10                  15    
 Arg Glu Gly Ala Gln Ala Xaa Gly Glu Ala Ser Asn Pro Gly Asn Pro
              20                  25                  30        
 Arg Arg Gly Gln Gly Ser Gly Gly Gly Thr Xaa Gly Asp Ser Ser Lys
          35                  40                  45            
 Gly Glu Arg Lys Gln Asp Arg Asn Lys Glu Lys Lys Glu Ala Leu Ser
      50                  55                  60                
 Lys Val Val Ile Arg Arg Leu Pro Pro Thr Leu Thr Lys Glu Gln Leu
  65                  70                  75                  80
 Gln Glu His Leu Gln Pro Met Pro Glu His Asp Tyr Phe Glu Leu Phe
                  85                  90                  95    
 Ser Asn Asp Thr Arg Leu Tyr Ala His Met Asp Ala Arg Ser Leu His
             100                 105                 110        
 Gln Leu
        



      <210> 726
      <211> 335
      <212> PRT
      <213> Homo sapiens


      <400> 726
 Ile Arg His Glu Glu Ile Ile Lys Val Thr Pro Leu Gln Gln Met Leu
   1               5                  10                  15    
 Ala Ser Cys Thr Gly Ala Ile Leu Thr Ser Val Ile Val Thr Pro Leu
              20                  25                  30        
 Asp Val Val Lys Ile Arg Leu Gln Ala Gln Asn Asn Pro Leu Pro Lys
          35                  40                  45            
 Gly Lys Cys Phe Val Tyr Ser Asn Gly Leu Met Asp His Leu Cys Val
      50                  55                  60                
 Cys Glu Glu Gly Gly Asn Lys Leu Trp Tyr Lys Lys Pro Gly Asn Phe
  65                  70                  75                  80
 Gln Gly Thr Leu Asp Ala Phe Phe Lys Ile Ile Arg Asn Glu Gly Ile
                  85                  90                  95    
 Lys Ser Leu Trp Ser Gly Leu Pro Pro Thr Leu Val Val Ala Val Pro
             100                 105                 110        
 Ala Thr Val Ile Tyr Phe Thr Cys Tyr Gly Gln Leu Ser Ala Leu Leu
         115                 120                 125            
 Arg Ser Lys Leu Gly Glu Asn Glu Thr Cys Ile Pro Ile Val Ala Gly
     130                 135                 140                
 Ile Val Ala Arg Phe Gly Ala Val Thr Val Ile Ser Pro Leu Glu Leu
 145                 150                 155                 160
 Ile Arg Thr Lys Met Gln Ser Lys Lys Phe Ser Tyr Val Glu Leu His
                 165                 170                 175    
 Arg Phe Val Ser Lys Lys Val Ser Glu Asp Gly Trp Ile Ser Leu Trp
             180                 185                 190        
 Arg Gly Trp Ala Pro Thr Val Leu Arg Asp Glu Pro Phe Ser Ala Met
         195                 200                 205            
 Tyr Trp Tyr Asn Tyr Gly Ile Leu Lys Lys Trp Leu Cys Glu Lys Ser
     210                 215                 220                
 Gly Leu Tyr Glu Pro Thr Phe Met Ile Asn Phe Thr Ser Gly Ala Leu
 225                 230                 235                 240
 Ser Gly Ser Phe Ala Ala Val Ala Thr Leu Pro Phe Asp Val Val Lys
                 245                 250                 255    
 Thr Gln Lys Gln Thr Gln Leu Trp Thr Tyr Glu Ser His Lys Ile Ser
             260                 265                 270        
 Met Pro Leu His Met Ser Thr Trp Ile Ile Met Lys Asn Ile Val Ala
         275                 280                 285            
 Lys Asn Gly Phe Ser Gly Leu Phe Pro Gly Leu Ile Pro Arg Leu Ile
     290                 295                 300                
 Leu Lys Leu Ala Pro Ala Cys Ala Ile Met Ile Ser Thr Tyr Glu Phe
 305                 310                 315                 320
 Gly Lys Ala Phe Phe Gln Lys Gln Asn Val Arg Arg Gln Gln Tyr
                 325                 330                 335



      <210> 727
      <211> 1186
      <212> PRT
      <213> Homo sapiens


      <400> 727
 Met Leu His His Pro Ser Gln Gly Phe Arg Phe Gly Thr Val Arg Glu
   1               5                  10                  15    
 Ser Ser Ala Glu Asp Tyr Val Arg Gln Ser Phe Pro Glu Met His Glu
              20                  25                  30        
 Tyr Met Arg Arg Tyr Asn Val Pro Ala Thr Pro Asp Gly Val Glu Tyr
          35                  40                  45            
 Leu Lys Asn Asp Pro Glu Lys Leu Asp Ala Phe Ile Met Asp Lys Ala
      50                  55                  60                
 Leu Leu Asp Tyr Glu Val Ser Ile Asp Ala Asp Cys Lys Leu Leu Thr
  65                  70                  75                  80
 Val Gly Lys Pro Phe Ala Ile Glu Ala Phe Phe Phe Leu Leu Ser Gln
                  85                  90                  95    
 Glu Arg Gly Ala Asp Glu Ala Arg Phe Arg Thr Phe Val Asp Ser Trp
             100                 105                 110        
 Pro Tyr Thr Thr Ala His Asp Met Asp Ser Leu Glu Phe Ser Asp Pro
         115                 120                 125            
 Ser His His Leu Asp Cys Pro Leu Gly Lys Thr Leu Asn Leu Tyr Pro
     130                 135                 140                
 Cys Gly Phe Ser Trp Asn Ser Cys Lys Leu Gln Gly Leu Pro Leu His
 145                 150                 155                 160
 Gly Met Lys Cys Glu Val His Leu Gly Pro Val Asn Ser Phe Gln Asp
                 165                 170                 175    
 Ser Gln Gly Val Pro Leu Pro Gly Thr Arg Asn Thr Cys Phe Pro Gly
             180                 185                 190        
 Val Asp His Leu Thr Ser Phe Thr Gly Lys Arg Leu Ser Ser Ser Ala
         195                 200                 205            
 Lys Met Ser Gly Ile Gly Asn Lys Arg Ala Ala Gly Glu Pro Gly Thr
     210                 215                 220                
 Ser Met Pro Pro Glu Lys Lys Ala Ala Val Glu Asp Ser Gly Thr Thr
 225                 230                 235                 240
 Val Glu Thr Ile Lys Leu Gly Gly Val Ser Ser Thr Glu Glu Leu Asp
                 245                 250                 255    
 Ile Arg Thr Leu Gln Thr Lys Asn Arg Lys Leu Ala Glu Met Leu Asp
             260                 265                 270        
 Gln Arg Gln Ala Ile Glu Asp Glu Leu Arg Glu His Ile Glu Lys Leu
         275                 280                 285            
 Glu Arg Arg Gln Ala Thr Asp Asp Ala Ser Leu Leu Ile Val Asn Arg
     290                 295                 300                
 Tyr Trp Ser Gln Phe Asp Glu Asn Ile Arg Ile Ile Leu Lys Arg Tyr
 305                 310                 315                 320
 Asp Leu Ser Arg Ala Trp Glu Thr Tyr Ser Gln Asn Glu Lys Pro Leu
                 325                 330                 335    
 Cys Val Pro Glu Pro Glu Pro Asp Ser Asp Ser Asn Gln Glu Arg Lys
             340                 345                 350        
 Asp Asp Arg Glu Arg Gly Lys Trp Glu Gly Gln Glu Pro Ala Phe Ser
         355                 360                 365            
 Phe Leu Ala Thr Leu Ala Ser Ser Ser Ser Glu Glu Met Glu Ser Gln
     370                 375                 380                
 Leu Gln Glu Arg Val Glu Ser Ser Arg Arg Ala Val Ser Gln Ile Val
 385                 390                 395                 400
 Thr Val Tyr Asp Lys Leu Gln Glu Lys Val Glu Leu Leu Ser Arg Lys
                 405                 410                 415    
 Leu Asn Ser Gly Asp Asn Leu Ile Val Glu Glu Ala Val Gln Glu Leu
             420                 425                 430        
 Asn Ser Phe Leu Ala Gln Glu Asn Met Arg Leu Gln Glu Leu Thr Asp
         435                 440                 445            
 Leu Leu Gln Glu Lys His Arg Thr Met Ser Gln Glu Phe Ser Lys Leu
     450                 455                 460                
 Gln Ser Lys Val Glu Thr Ala Glu Ser Arg Val Ser Val Leu Glu Ser
 465                 470                 475                 480
 Met Ile Asp Asp Leu Gln Trp Asp Ile Asp Lys Ile Arg Lys Arg Glu
                 485                 490                 495    
 Gln Arg Leu Asn Arg His Leu Ala Glu Val Leu Glu Arg Val Asn Ser
             500                 505                 510        
 Lys Gly Tyr Lys Val Tyr Gly Ala Gly Ser Ser Leu Tyr Gly Gly Thr
         515                 520                 525            
 Ile Thr Ile Asn Ala Arg Lys Phe Glu Glu Met Asn Ala Glu Leu Glu
     530                 535                 540                
 Glu Asn Lys Glu Leu Ala Gln Asn Arg Leu Cys Glu Leu Glu Lys Leu
 545                 550                 555                 560
 Arg Gln Asp Phe Glu Glu Val Thr Thr Gln Asn Glu Lys Leu Lys Val
                 565                 570                 575    
 Glu Leu Arg Ser Ala Val Glu Gln Val Val Lys Glu Thr Pro Glu Tyr
             580                 585                 590        
 Arg Cys Met Gln Ser Gln Phe Ser Val Leu Tyr Asn Glu Ser Leu Gln
         595                 600                 605            
 Leu Lys Ala His Leu Asp Glu Ala Arg Thr Leu Leu His Gly Thr Arg
     610                 615                 620                
 Gly Thr His Gln His Gln Val Glu Leu Ile Glu Arg Asp Glu Val Ser
 625                 630                 635                 640
 Leu His Lys Lys Leu Arg Thr Glu Val Ile Gln Leu Glu Asp Thr Leu
                 645                 650                 655    
 Ala Gln Val Arg Lys Glu Tyr Glu Met Leu Arg Ile Glu Phe Glu Gln
             660                 665                 670        
 Thr Leu Ala Ala Asn Glu Gln Ala Gly Pro Ile Asn Arg Glu Met Arg
         675                 680                 685            
 His Leu Ile Ser Ser Leu Gln Asn His Asn His Gln Leu Lys Gly Glu
     690                 695                 700                
 Val Leu Arg Tyr Lys Arg Lys Leu Arg Glu Ala Gln Ser Asp Leu Asn
 705                 710                 715                 720
 Lys Thr Arg Leu Arg Ser Gly Ser Ala Leu Leu Gln Ser Gln Ser Ser
                 725                 730                 735    
 Thr Glu Asp Pro Lys Asp Glu Pro Ala Glu Leu Lys Pro Asp Ser Gly
             740                 745                 750        
 Thr Tyr Pro Pro Ser Pro Gln Pro Gln Arg His Leu Arg Arg Met Pro
         755                 760                 765            
 Met Lys Ser Ser Leu Asn Gly Met Lys Lys Asn Glu Asn Glu Lys Gly
     770                 775                 780                
 Gly Arg Arg Arg Gly Asn Glu Lys Glu Thr Arg Glu Lys Glu Lys Glu
 785                 790                 795                 800
 Arg Glu Arg Glu Lys Gln Lys Leu Lys Glu Ser Glu Lys Glu Arg Asp
                 805                 810                 815    
 Ser Ala Lys Asp Lys Glu Lys Gly Lys His Asp Asp Gly Arg Lys Lys
             820                 825                 830        
 Glu Ala Glu Ile Ile Lys Gln Leu Lys Ile Glu Leu Lys Lys Ala Gln
         835                 840                 845            
 Glu Ser Gln Lys Glu Met Lys Leu Leu Leu Asp Met Tyr Arg Ser Ala
     850                 855                 860                
 Pro Lys Glu Gln Arg Asp Lys Val Gln Leu Met Ala Ala Glu Lys Lys
 865                 870                 875                 880
 Ser Lys Ala Glu Leu Glu Asp Leu Arg Gln Arg Leu Lys Asp Leu Glu
                 885                 890                 895    
 Asp Lys Glu Lys Lys Glu Asn Lys Lys Met Ala Asp Glu Asp Ala Leu
             900                 905                 910        
 Arg Lys Ile Arg Ala Val Glu Glu Gln Ile Glu Tyr Leu Gln Lys Lys
         915                 920                 925            
 Leu Ala Met Ala Lys Gln Glu Glu Glu Ala Leu Leu Ser Glu Met Asp
     930                 935                 940                
 Val Thr Gly Gln Ala Phe Glu Asp Met Gln Glu Gln Asn Ile Arg Leu
 945                 950                 955                 960
 Met Gln Gln Leu Arg Glu Lys Asp Asp Ala Asn Phe Lys Leu Met Ser
                 965                 970                 975    
 Glu Arg Ile Lys Ser Asn Gln Ile His Lys Leu Leu Lys Glu Glu Lys
             980                 985                 990        
 Glu Glu Leu Ala Asp Gln Val Leu Thr Leu Lys Thr Gln Val Asp Ala
         995                1000                1005            
 Gln Leu Gln Val Val Arg Lys Leu Glu Glu Lys Glu His Leu Leu Gln
    1010                1015                1020                
 Ser Asn Ile Gly Thr Gly Glu Lys Glu Leu Gly Leu Arg Thr Gln Ala
1025                1030                1035                1040
 Leu Glu Met Asn Lys Arg Lys Ala Met Glu Ala Ala Gln Leu Ala Asp
                1045                1050                1055    
 Asp Leu Lys Ala Gln Leu Glu Leu Ala Gln Lys Lys Leu His Asp Phe
            1060                1065                1070        
 Gln Asp Glu Ile Val Glu Asn Ser Val Thr Lys Glu Lys Asp Met Phe
        1075                1080                1085            
 Asn Phe Lys Arg Ala Gln Glu Asp Ile Ser Arg Leu Arg Arg Lys Leu
    1090                1095                1100                
 Glu Thr Thr Lys Lys Pro Asp Asn Val Pro Lys Cys Asp Glu Ile Leu
1105                1110                1115                1120
 Met Glu Glu Ile Lys Asp Tyr Lys Ala Arg Leu Thr Cys Pro Cys Cys
                1125                1130                1135    
 Asn Met Arg Lys Lys Asp Ala Val Leu Thr Lys Cys Phe His Val Phe
            1140                1145                1150        
 Cys Phe Glu Cys Val Lys Thr Arg Tyr Asp Thr Arg Gln Arg Lys Cys
        1155                1160                1165            
 Pro Lys Cys Asn Ala Ala Phe Gly Ala Asn Asp Phe His Arg Ile Tyr
    1170                1175                1180                
 Ile Gly
1185    



      <210> 728
      <211> 36
      <212> PRT
      <213> Homo sapiens


      <400> 728
 Pro Leu Asn Phe Arg Pro Ile Phe Pro Val Ile Phe Gly Ile Ser Cys
   1               5                  10                  15    
 Ser Arg Ile Phe Lys Gln Val Phe Arg Ala Cys Val Arg Pro Ser His
              20                  25                  30        
 Ser Asp Phe Leu
          35    



      <210> 729
      <211> 331
      <212> PRT
      <213> Homo sapiens


      <400> 729
 Met Ala Ala Thr Pro Pro His Arg Ala Gly Pro Asn Pro Cys Arg His
   1               5                  10                  15    
 Ser Arg His Leu Ser Glu Gly Arg Glu Glu Thr Arg Thr His Pro His
              20                  25                  30        
 Ser Pro His Thr His Gly Gly Gly Val Glu Gly Pro Ala Pro Pro Ala
          35                  40                  45            
 Ser Arg Leu Gln Arg Asp Lys Val Thr His Pro Gly Ala Arg Gln Arg
      50                  55                  60                
 Ala Gly Cys Ala Leu Thr Arg Ala Arg Arg Pro Arg Ala Ser Asp Ala
  65                  70                  75                  80
 Gly Ser Ser Ser Ser Ser Arg Arg Arg Arg Arg Arg His Leu Arg Pro
                  85                  90                  95    
 Ser Thr Ser Ala Asp Gly Gly Arg Glu Arg Val Ala Ala Leu Lys Arg
             100                 105                 110        
 Val Leu Tyr Leu Val Trp Ala Phe Ile Pro Glu Ser Trp Leu Asn Ser
         115                 120                 125            
 Leu Gly Leu Thr Tyr Trp Pro Gln Lys Tyr Trp Ala Val Ala Leu Pro
     130                 135                 140                
 Val Tyr Leu Leu Ile Ala Ile Val Ile Gly Tyr Val Leu Leu Phe Gly
 145                 150                 155                 160
 Ile Asn Met Met Ser Thr Ser Pro Leu Asp Ser Ile His Thr Ile Thr
                 165                 170                 175    
 Gly His Glu Arg Asn Thr Asn Val Leu Gln Thr Met Gly Ser Ser Val
             180                 185                 190        
 Phe Glu Gly His Asp Gln Phe Ser Val Thr Val Thr Gly Asp Pro Met
         195                 200                 205            
 Ala Arg Ala Gly Arg Ser Gln Leu Glu Pro His Ser Asp Ser Asp Ala
     210                 215                 220                
 Thr Leu Gln Leu His Cys Ser Gln Pro Thr Cys Val Ile Lys Pro Val
 225                 230                 235                 240
 Tyr Thr Lys Pro Ser Ile Leu Glu Ala Ala Val Ser Gln Pro Ala Ser
                 245                 250                 255    
 Ala Ala Ala Ala Ala Pro Arg Gly Pro Ser Leu Pro Val Ile Leu Trp
             260                 265                 270        
 Phe Leu Arg Gln Pro Leu Leu Asn Val Leu Ser Glu Cys Thr Met Gly
         275                 280                 285            
 Gly His Ile Leu Gly Lys Val Gln Ser Leu Thr Pro His His His Ser
     290                 295                 300                
 Val Lys Asp Leu Arg Thr Trp Gln Glu Leu Lys Cys Ser Val Tyr Leu
 305                 310                 315                 320
 Ile Ala Asp Gly Ala Arg Phe Ser Ser Ala Ala
                 325                 330    



      <210> 730
      <211> 113
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(113)
      <223> Xaa = any amino acid or nothing 


      <400> 730
 Leu Trp Pro Leu Gly Pro Glu Pro Arg Ala Gly Cys Ile Cys Arg Gly
   1               5                  10                  15    
 Asn Leu Ser Ser Thr Arg Gly Thr Ser Thr Arg Pro Gly Ala Thr Ala
              20                  25                  30        
 Asp Phe Gly Leu His His Gly Gly Leu Pro Ala Gly Leu Ser Ser Cys
          35                  40                  45            
 Ser Ala Gly Val Pro Thr Ser Thr Cys Cys Ala Gly Lys Xaa Asn Leu
      50                  55                  60                
 Xaa Phe Gly Leu Pro Arg Gly Cys Ser Cys Pro Gly Phe Leu Pro Ser
  65                  70                  75                  80
 Lys Gly Thr Ile Ile Leu Asp Cys Val Asn Lys Asp Leu Lys Asn Gly
                  85                  90                  95    
 Lys Ala Thr Pro Lys Asp Ser Lys Tyr Val Glu Lys Leu Lys Ala Leu
             100                 105                 110        
 Phe
    



      <210> 731
      <211> 112
      <212> PRT
      <213> Homo sapiens


      <400> 731
 Glu Asp Glu Lys Val Glu Arg Val Pro Ser Pro Asp His Arg Arg Arg
   1               5                  10                  15    
 Ser Tyr Arg Asp Leu Asp Lys Pro Arg Arg Ser Pro Thr Leu Arg Tyr
              20                  25                  30        
 Arg Arg Ser Arg Ser Arg Ser Pro Ile Arg Arg Ser Arg Ser Pro Lys
          35                  40                  45            
 Arg Arg Ser Pro Phe Pro Arg Arg Glu Arg His Arg Ser Lys Ser Ser
      50                  55                  60                
 Arg Arg His Arg Ser Arg Ser Arg Asp Arg Arg His Arg Ser Arg Ser
  65                  70                  75                  80
 Lys Ser Pro Gly His His Arg Ser His Arg His Arg Ser His Ser Lys
                  85                  90                  95    
 Ser Pro Glu Arg Ser Lys Lys Ser His Lys Ile Ser Arg Ser Arg Glu
             100                 105                 110        





      <210> 732
      <211> 36
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(36)
      <223> Xaa = any amino acid or nothing 


      <400> 732
 Met His Arg Arg Leu Val Ala Ser Pro Xaa Ser Val Tyr Val Arg Gln
   1               5                  10                  15    
 Ser Val His Met Leu Val Cys Phe Pro Met Ala Ser Asp Lys Xaa Leu
              20                  25                  30        
 Asn Lys Tyr Leu
          35    



      <210> 733
      <211> 341
      <212> PRT
      <213> Homo sapiens


      <400> 733
 Glu Glu Thr Ser Gly His Cys Val Val Val Gly Pro Ala Ala Lys Arg
   1               5                  10                  15    
 Phe Ser Ala Gly Cys Phe Pro Arg Phe Pro Arg Pro Val Pro Arg Ala
              20                  25                  30        
 Leu Leu Ile Ala Pro Gly Pro Ser Val Ser Ala Arg Leu Thr Val Gly
          35                  40                  45            
 Cys Asp Asp Met Ser Asn Lys Glu Gly Ser Gly Gly Phe Arg Lys Arg
      50                  55                  60                
 Lys His Asp Asn Phe Pro His Asn Gln Arg Arg Glu Gly Lys Asp Val
  65                  70                  75                  80
 Asn Ser Ser Ser Pro Val Met Leu Ala Phe Lys Ser Phe Gln Gln Glu
                  85                  90                  95    
 Leu Asp Ala Arg His Asp Lys Tyr Glu Arg Leu Val Lys Leu Ser Arg
             100                 105                 110        
 Asp Ile Thr Val Glu Ser Lys Arg Thr Ile Phe Leu Leu His Arg Ile
         115                 120                 125            
 Thr Ser Ala Pro Asp Met Glu Asp Ile Leu Thr Glu Ser Glu Ile Lys
     130                 135                 140                
 Leu Asp Gly Val Arg Gln Lys Ile Phe Gln Val Ala Gln Glu Leu Ser
 145                 150                 155                 160
 Gly Glu Asp Met His Gln Phe His Arg Ala Ile Thr Thr Gly Leu Gln
                 165                 170                 175    
 Glu Tyr Val Glu Ala Val Ser Phe Gln His Phe Ile Lys Thr Arg Ser
             180                 185                 190        
 Leu Ile Ser Met Asp Glu Ile Asn Lys Gln Leu Ile Phe Thr Thr Glu
         195                 200                 205            
 Asp Asn Gly Lys Glu Asn Lys Thr Pro Ser Ser Asp Ala Gln Asp Lys
     210                 215                 220                
 Gln Phe Gly Thr Trp Arg Leu Arg Val Thr Pro Val Asp Tyr Leu Leu
 225                 230                 235                 240
 Gly Val Ala Asp Leu Thr Gly Glu Leu Met Arg Met Cys Ile Asn Ser
                 245                 250                 255    
 Val Gly Asn Gly Asp Ile Asp Thr Pro Phe Glu Val Ser Gln Phe Leu
             260                 265                 270        
 Arg Gln Val Tyr Asp Gly Phe Ser Phe Ile Gly Asn Thr Gly Pro Tyr
         275                 280                 285            
 Glu Val Ser Lys Lys Leu Tyr Thr Leu Lys Gln Ser Leu Ala Lys Val
     290                 295                 300                
 Glu Asn Ala Cys Tyr Ala Leu Lys Val Arg Gly Ser Glu Ile Pro Lys
 305                 310                 315                 320
 His Met Leu Ala Asp Val Phe Ser Val Lys Thr Glu Met Ile Asp Gln
                 325                 330                 335    
 Glu Glu Gly Ile Ser
             340    



      <210> 734
      <211> 84
      <212> PRT
      <213> Homo sapiens


      <400> 734
 Met Asp His Glu Phe Val Ala Lys Gly His Leu Phe Arg Lys Gly Ile
   1               5                  10                  15    
 Met Lys Ile Met Val Tyr Lys Ile Phe Arg Ile Leu Val Pro Gly Asn
              20                  25                  30        
 Thr Asp Ser Thr Glu Ala Leu Ser Leu Ser Tyr Leu Val Glu Leu Ser
          35                  40                  45            
 Val Val Ala Pro Ala Gly Gln Asp Met Val Ser Asp Asp Met Lys Asn
      50                  55                  60                
 Phe Ala Glu Gln Leu Lys Pro Leu Val His Leu Glu Lys Ile Asp Pro
  65                  70                  75                  80
 Lys Arg Leu Met
                



      <210> 735
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 735
 Pro Arg Val Arg Gly Ile Leu Pro Ser Cys Ser Val Val Val Phe Ser
   1               5                  10                  15    
 Leu Leu Leu Leu Leu Leu Leu Arg Leu Gly Glu Pro Ser Trp Gly Arg
              20                  25                  30        
 Met Val Cys Glu Lys Cys Glu Lys Lys Leu Gly Thr Val Ile Thr Pro
          35                  40                  45            
 Asp Thr Trp Lys Asp Gly Ala Arg Asn Thr Thr Glu Asn Gly Gly Arg
      50                  55                  60                
 Lys Leu Asn Glu Asn Lys Ala Leu Thr Ser Lys Lys Ala Arg Phe Asp
  65                  70                  75                  80
 Pro Tyr Gly Lys Asn Lys Phe Ser Thr Cys Arg Ile Cys Lys Ser Ser
                  85                  90                  95    
 Val His Gln Pro Gly Ser His Tyr Cys Gln Gly Cys Ala Tyr Lys Lys
             100                 105                 110        
 Gly Ile Cys Ala Met Cys Gly Lys Lys Val Leu Asp Thr Lys Asn Tyr
         115                 120                 125            
 Lys Gln Thr Ser Val
     130            



      <210> 736
      <211> 54
      <212> PRT
      <213> Homo sapiens


      <400> 736
 Val Ile Pro Gln Ile Gln Lys Val Cys Glu Val Val Asp Gly Phe Ile
   1               5                  10                  15    
 Tyr Val Ala Asn Ala Glu Ala His Lys Val Gln Asp Thr Glu Ala Glu
              20                  25                  30        
 Thr Leu Thr Gly Phe Leu Asn Gly Ile Glu Trp Ile Leu Glu Glu Val
          35                  40                  45            
 Glu Ser Lys Arg Ala Arg
      50                



      <210> 737
      <211> 161
      <212> PRT
      <213> Homo sapiens


      <400> 737
 Glu Ser Gly Gln Val Lys Leu Arg Pro Val Ser Ser Ala Ser Arg Gly
   1               5                  10                  15    
 Leu Arg Pro Ala Lys Pro Arg Arg Thr Thr Met Leu Lys Ala Lys Ile
              20                  25                  30        
 Leu Phe Val Gly Pro Cys Glu Ser Gly Lys Thr Val Leu Thr Asn Phe
          35                  40                  45            
 Leu Thr Glu Ser Ser Asp Ile Thr Glu Tyr Ser Pro Thr Gln Gly Val
      50                  55                  60                
 Arg Phe Glu Pro Cys Trp Pro Ala Leu Met Lys Asp Ala His Gly Val
  65                  70                  75                  80
 Ala Ile Val Phe Asp Ala Asp Ile Pro Ser His Arg Lys Glu Leu Glu
                  85                  90                  95    
 Met Trp Asp Ser Cys Phe Cys Gln Gln Pro Ser Leu Gln Asp Thr Gln
             100                 105                 110        
 Cys Met Leu Ile Ala His His Lys Pro Ser Ser Gly Asp Asp Lys Gly
         115                 120                 125            
 Ser Leu Ser Leu Ser Pro Pro Leu Asn Lys Leu Lys Leu Val His Ser
     130                 135                 140                
 Asn Leu Glu Asp Asp Pro Glu Glu Ile Arg Met Glu Phe Ile Lys Tyr
 145                 150                 155                 160
 Leu
    



      <210> 738
      <211> 263
      <212> PRT
      <213> Homo sapiens


      <400> 738
 Met Gly Phe Arg His Val Gly Gln Ala Gly Leu Lys Leu Leu Thr Ser
   1               5                  10                  15    
 Ser Asp Leu Pro Ala Leu Ala Ser Gln Val Gln Cys Lys Leu Val Val
              20                  25                  30        
 Pro Ala Ser Ala Glu Arg His Ile Ser Pro Leu Gln Arg Gly Leu Ile
          35                  40                  45            
 Ala Phe Ser Leu Arg Pro Asp Pro Gly Leu Ala Gly Asp Arg Ala Ser
      50                  55                  60                
 Leu Gly Val Pro Leu Cys Gly Tyr Arg Ile Gly Asn Pro Arg Arg Ser
  65                  70                  75                  80
 Pro Lys Arg Thr Arg His Cys Ala Arg Thr Ala Ala Val Ser Cys Ser
                  85                  90                  95    
 Ala Tyr Ser Lys Cys Leu Tyr Gln Phe Arg Pro Asn Val Gly His Ser
             100                 105                 110        
 Ala Ser Thr Pro Lys Ala Met Cys Gln Thr Thr Ala Ala Gly Glu Gly
         115                 120                 125            
 Ala His Ala Ala Asp Glu Gly Tyr Thr Gln Arg Val Val Gly Ala Arg
     130                 135                 140                
 Arg Gly Thr Pro Gln Arg Tyr Thr Gly Gly Ala Glu Thr Lys Asn Arg
 145                 150                 155                 160
 Ala Phe Arg Ser Tyr Pro Lys Met Glu Thr Ser Trp Pro Arg Gly Gly
                 165                 170                 175    
 Gly Ser Thr Pro Pro Val Ala Leu Asp Ala Gln Val Glu Arg Glu Cys
             180                 185                 190        
 Ala Leu Gly Ser Gly Ala Gln Gly Lys His Ser Cys Leu Ala Val Arg
         195                 200                 205            
 Val Val Leu Ile Phe Cys Ile Asn Glu His Tyr Pro Gln Thr Leu Thr
     210                 215                 220                
 Tyr Arg Leu Pro Phe Val Leu Pro Leu Arg Ser Gly Gly Thr Pro Thr
 225                 230                 235                 240
 Ser Trp Arg Ala Leu Phe Phe Pro Ser Ser Ser Asp Ser Asn Cys Lys
                 245                 250                 255    
 Leu Cys Gly Gly Thr Ser Ser
             260            



      <210> 739
      <211> 59
      <212> PRT
      <213> Homo sapiens


      <400> 739
 Ser Arg Arg Arg Gly Gly Val Ser Ala Pro Thr Ser Phe Tyr Gly Arg
   1               5                  10                  15    
 Asp Arg Arg Met Phe Pro Ala Gln Glu Glu Ala Asp Arg Thr Val Phe
              20                  25                  30        
 Val Gly Asn Leu Glu Ala Arg Val Arg Glu Glu Ile Leu Tyr Glu Leu
          35                  40                  45            
 Phe Leu Gln Cys Cys Ser Phe Leu Thr Met Lys
      50                  55                



      <210> 740
      <211> 525
      <212> PRT
      <213> Homo sapiens


      <400> 740
 His Gly Asp Val Ser Pro Arg Cys Leu Phe Lys Glu Gly Ser Ala Ala
   1               5                  10                  15    
 Gln Leu Gln Thr Leu Glu Leu Ala Gly Ser Leu His Leu Ser Ala Pro
              20                  25                  30        
 Ser Gly Ser Ala Lys Ala Thr Lys Val Glu Ser Leu Gln Ser Arg Ile
          35                  40                  45            
 Tyr Ile His Leu Leu Val Val Leu Met Ala Val Thr Ala Cys Leu Glu
      50                  55                  60                
 Gln Leu Leu Arg Gly Cys Gln Leu Gln Tyr Gly Arg Arg Gly Gln Ser
  65                  70                  75                  80
 Cys Pro Leu Leu Arg Asp Ser Gly Arg Gln Glu His Ala Arg Ala Pro
                  85                  90                  95    
 Ser Pro Thr Thr Ser Ala Arg Arg Glu Thr His Val Pro Gly His Ser
             100                 105                 110        
 Cys Ser Arg Pro Ala Ala Ala Leu His Pro Ala Ile Pro Ala Leu Leu
         115                 120                 125            
 Gly Ala Gln Glu Thr Pro Cys Pro Cys Arg Leu Lys Val Pro Ala Pro
     130                 135                 140                
 Glu Val Ala Val His Ser Met Ser Ala Ser Ala Pro Ala Ala Glu Gly
 145                 150                 155                 160
 Glu Gly Thr Pro Thr Gln Pro Ala Ser Glu Lys Asp Pro Glu Met Pro
                 165                 170                 175    
 Gly Pro Arg Glu Glu Ser Glu Glu Glu Glu Asp Glu Asp Asp Glu Glu
             180                 185                 190        
 Glu Glu Glu Glu Glu Lys Glu Lys Ser Leu Ile Val Glu Gly Lys Arg
         195                 200                 205            
 Glu Lys Lys Lys Val Glu Arg Leu Thr Met Gln Val Ser Ser Leu Gln
     210                 215                 220                
 Arg Glu Pro Phe Thr Ile Ala Gln Gly Lys Gly Gln Lys Leu Cys Glu
 225                 230                 235                 240
 Ile Glu Arg Ile His Phe Phe Leu Ser Lys Lys Lys Thr Asp Glu Leu
                 245                 250                 255    
 Arg Asn Leu His Lys Leu Leu Tyr Asn Arg Pro Gly Thr Val Ser Ser
             260                 265                 270        
 Leu Lys Lys Asn Val Gly Gln Phe Ser Gly Phe Pro Phe Glu Lys Gly
         275                 280                 285            
 Ser Val Gln Tyr Lys Lys Lys Glu Glu Met Leu Lys Lys Phe Arg Asn
     290                 295                 300                
 Ala Met Leu Lys Ser Ile Cys Glu Val Leu Asp Leu Glu Arg Ser Gly
 305                 310                 315                 320
 Val Asn Ser Glu Leu Val Lys Arg Ile Leu Asn Phe Leu Met His Pro
                 325                 330                 335    
 Lys Arg Ser Gly Lys Pro Leu Pro Lys Phe Lys Lys Ser Cys Ser Lys
             340                 345                 350        
 Gly Ser Lys Lys Asp Arg Asn Ser Ser Gly Met Ala Ser Lys Ala Lys
         355                 360                 365            
 Arg Thr Lys Cys Pro Glu Ile Leu Ser Asp Glu Ser Ser Ser Asp Glu
     370                 375                 380                
 Asp Glu Lys Lys Asn Lys Glu Glu Ser Ser Asp Asp Glu Asp Lys Glu
 385                 390                 395                 400
 Ser Glu Glu Glu Pro Ser Lys Lys Thr Val Lys Arg Glu Lys Pro Lys
                 405                 410                 415    
 Gln Arg Ala Thr Ser Lys Ser Lys Lys Ser Val Lys Ser Ala Asn Val
             420                 425                 430        
 Lys Lys Ala Asp Ser Ser Thr Thr Lys Lys Asn Gln Asn Ser Ser Lys
         435                 440                 445            
 Lys Glu Ser Glu Ser Glu Asp Ser Ser Asp Asp Glu Pro Leu Ile Lys
     450                 455                 460                
 Lys Leu Lys Lys Pro Pro Thr Asp Glu Glu Leu Lys Glu Thr Ile Lys
 465                 470                 475                 480
 Lys Leu Leu Ala Ser Ala Asn Leu Glu Glu Val Thr Met Lys Gln Ile
                 485                 490                 495    
 Cys Lys Lys Val Tyr Glu Asn Tyr Pro Thr Tyr Asp Leu Thr Glu Arg
             500                 505                 510        
 Lys Asp Phe Ile Lys Thr Thr Val Lys Glu Leu Ile Ser
         515                 520                 525



      <210> 741
      <211> 72
      <212> PRT
      <213> Homo sapiens


      <400> 741
 Ser Arg Ser Ala Ala His Cys Cys His Gly Gly Thr Lys Met Ala Ala
   1               5                  10                  15    
 Leu Ala Tyr Asn Leu Gly Lys Arg Glu Ile Asn His Ser Cys Met Met
              20                  25                  30        
 His Lys Tyr Lys Ile Ser Glu Ala Lys Asn Cys Leu Val Asp Lys His
          35                  40                  45            
 Ile Ala Phe Ile Gly Asp Ser Arg Ile Arg Gln Leu Phe Tyr Ser Phe
      50                  55                  60                
 Val Lys Ile Ile Asn Pro Gln Phe
  65                  70        



      <210> 742
      <211> 72
      <212> PRT
      <213> Homo sapiens


      <400> 742
 Ser Arg Ser Ala Ala His Cys Cys His Gly Gly Thr Lys Met Ala Ala
   1               5                  10                  15    
 Leu Ala Tyr Asn Leu Gly Lys Arg Glu Ile Asn His Ser Cys Met Met
              20                  25                  30        
 His Lys Tyr Lys Ile Ser Glu Ala Lys Asn Cys Leu Val Asp Lys His
          35                  40                  45            
 Ile Ala Phe Ile Gly Asp Ser Arg Ile Arg Gln Leu Phe Tyr Ser Phe
      50                  55                  60                
 Val Lys Ile Ile Asn Pro Gln Phe
  65                  70        



      <210> 743
      <211> 230
      <212> PRT
      <213> Homo sapiens


      <400> 743
 Ser Leu Pro Arg Arg Leu Glu Ser Pro Gly Arg Leu Ala Met Ala Ala
   1               5                  10                  15    
 Arg Gly Val Ile Ala Pro Val Gly Glu Ser Leu Cys Arg Tyr Ala Glu
              20                  25                  30        
 Val Pro Cys Ser Pro Ser Ala Lys Arg Pro Asp Ala Asp Val Asp Gln
          35                  40                  45            
 Gln Arg Leu Val Arg Ser Leu Ile Ala Val Gly Gln Gly Val Ala Ala
      50                  55                  60                
 Leu Ala Phe Ala Gly Arg Tyr Ala Leu Arg Ile Trp Lys Pro Leu Glu
  65                  70                  75                  80
 Gln Val Ile Thr Glu Thr Ala Lys Gly Arg Phe Gln Thr Pro Ser Phe
                  85                  90                  95    
 Ser Ser Tyr Tyr Lys Gly Gly Phe Asp Gln Lys Met Ser Arg Arg Glu
             100                 105                 110        
 Ala Gly Leu Ile Leu Gly Val Ser Pro Ser Ala Gly Lys Ala Lys Ile
         115                 120                 125            
 Arg Thr Ala His Arg Arg Val Met Ile Leu Glu Ser Pro Gln Ile Lys
     130                 135                 140                
 Gly Gly Ser Pro Tyr Val Ala Ala Lys Ile Asn Glu Ala Lys Asp Leu
 145                 150                 155                 160
 Leu Glu Thr Thr Pro Pro Thr Leu Met Leu Lys Asp His Thr Glu Gly
                 165                 170                 175    
 Lys Lys Asn Glu Gly Thr Ser Lys Lys Lys Lys Ser Pro Ala Lys Tyr
             180                 185                 190        
 Ser Lys Thr Trp Ser Phe Leu Ile Phe Tyr Met Gly Phe Asp His Ser
         195                 200                 205            
 Leu Ile Phe Arg Pro Leu Ser Cys Ile Thr Asn Lys Met Leu Ile Val
     210                 215                 220                
 Leu Leu Phe Ile Ile Phe
 225                 230



      <210> 744
      <211> 244
      <212> PRT
      <213> Homo sapiens


      <400> 744
 Ala Arg Gly Asn Leu Asn His His Pro Gly Ala Ala Val Val Ala Pro
   1               5                  10                  15    
 Cys Val Arg Leu Val Pro Cys Ser Leu Leu Val Leu Ala Leu Ser Leu
              20                  25                  30        
 Arg Pro Ser Pro Arg Val Leu His Thr Ala Thr Lys Gln Lys Asn Ser
          35                  40                  45            
 Cys Gln His Leu Glu Glu Asp Val Asp Gln Thr Lys Trp Arg Thr Asp
      50                  55                  60                
 Thr Pro Ser Met Asp Lys Ile Leu Met Glu Glu Val Lys Leu Glu Glu
  65                  70                  75                  80
 Gln Leu Lys Glu Ala Val Glu Glu Asp Lys Gln Ala Leu Ala Asp Thr
                  85                  90                  95    
 Glu Gly Ser Glu Gln Ser Ser Gln Lys Leu Val Glu Glu Gly Asn Met
             100                 105                 110        
 Tyr Ser Ile Gln Gly Phe Cys Lys Asp Ser Leu Glu Val Ala Asp Val
         115                 120                 125            
 Leu Glu Lys Ala Thr Gln Cys Val Pro Glu Glu Glu Ile Lys Asp Asn
     130                 135                 140                
 Asn Pro His Leu Lys Asn Leu Ser Leu Trp Asp His Leu Val Ala Gly
 145                 150                 155                 160
 Lys Glu Gly Gln Asp Ser Gln Ser Phe Tyr Ile Met Ser Met Glu Lys
                 165                 170                 175    
 Leu Ser Ser Thr Lys Leu Val Pro Ala Pro Pro Lys Ile Gly Asp Arg
             180                 185                 190        
 Cys Thr Gln His Arg Glu Lys Asn Lys Lys Leu Lys Ser Leu Pro Leu
         195                 200                 205            
 Ser Pro Gln Pro Arg Cys Leu Thr Pro Leu Ser Leu Met Gln Gln Glu
     210                 215                 220                
 Ala Pro Gly Glu Arg Phe Ser Pro Ile Leu Tyr Phe Cys His Val Leu
 225                 230                 235                 240
 Ile Thr Val Trp
                



      <210> 745
      <211> 38
      <212> PRT
      <213> Homo sapiens


      <400> 745
 Cys Gly Gln Val His Met Ala Asn Lys Trp Gln Thr Glu Glu Val Ser
   1               5                  10                  15    
 Pro Pro Ser Ala Leu Leu Val Val Ala Gly Pro Met Pro Leu Leu Pro
              20                  25                  30        
 Arg Thr Pro Leu Ser Ser
          35            



      <210> 746
      <211> 217
      <212> PRT
      <213> Homo sapiens


      <400> 746
 Met Leu Gln Gln Asp Ser Asn Asp Asp Thr Lys Asp Val Ser Leu Phe
   1               5                  10                  15    
 Asp Ala Glu Glu Glu Thr Thr Asn Arg Pro Arg Lys Val Lys Ile Arg
              20                  25                  30        
 His Pro Val Ala Ser Phe Phe His Leu Phe Phe Arg Val Ser Ala Ile
          35                  40                  45            
 Ile Val Cys Leu Leu Cys Glu Leu Leu Ser Ser Ser Phe Ile Thr Cys
      50                  55                  60                
 Met Val Thr Ile Ile Leu Leu Ser Cys Asp Phe Trp Ala Val Lys Asn
  65                  70                  75                  80
 Ile Thr Gly Arg Leu Met Val Gly Leu Arg Trp Trp Asn His Val Asp
                  85                  90                  95    
 Glu Asp Gly Lys Ser His Trp Val Phe Glu Ser Arg Lys Glu Ser Ser
             100                 105                 110        
 Gln Glu Asn Glu Thr Val Ser Glu Ala Glu Ser Gly Ile Phe Trp Leu
         115                 120                 125            
 Gly Leu Val Ala Cys Pro Val Leu Trp Val Ile Leu Ala Phe Ser Ala
     130                 135                 140                
 Arg Phe Ser Phe Arg Val Lys Lys Trp Leu Ala Val Val Ile Val Gly
 145                 150                 155                 160
 Val Val Leu Gln Gly Ala Asn Leu Tyr Gly Tyr Leu Arg Cys Lys Val
                 165                 170                 175    
 Pro Ser Val Arg Ile Glu Ser Leu Asp Thr Gln Leu Gly Ile Gln Asn
             180                 185                 190        
 Trp Arg Ile Gly Trp Tyr Glu Gly Lys Ala His Thr Ser Gly Val Arg
         195                 200                 205            
 Ser Val Gly Asn Arg Asn Arg Ser Glu
     210                 215        



      <210> 747
      <211> 231
      <212> PRT
      <213> Homo sapiens


      <400> 747
 Gly His Arg Pro Thr Trp Leu Ala Phe Pro Leu Leu Asn Gly Val Cys
   1               5                  10                  15    
 Cys Ser Cys Pro Leu Arg Ala Leu Phe Pro Gly Ile Leu Asp Phe Arg
              20                  25                  30        
 Val Gly Gln Gln Ala Gly Lys Met Leu Ser Ser Ile Lys Cys Val Leu
          35                  40                  45            
 Val Gly Asp Ser Ala Val Gly Lys Thr Phe Leu Val Val Arg Phe Thr
      50                  55                  60                
 Ser Arg Thr Leu Arg Glu Gly Tyr Ser Pro Pro Val Tyr Glu Asn Thr
  65                  70                  75                  80
 Gly Val Asp Val Phe Met Asp Gly Ile Gln Ile Ser Leu Gly Leu Trp
                  85                  90                  95    
 Asp Thr Ala Ala Asn Asp Ala Phe Arg Ser Ile Arg Pro Leu Ser Tyr
             100                 105                 110        
 Gln Gln Ala Asp Val Val Leu Met Cys Tyr Ser Val Ala Asn His Asn
         115                 120                 125            
 Ser Phe Leu Asn Leu Lys Asn Lys Trp Ile Gly Glu Ile Arg Ser Asn
     130                 135                 140                
 Leu Pro Cys Thr Pro Val Leu Val Val Ala Thr Gln Thr Asp Gln Arg
 145                 150                 155                 160
 Glu Met Gly Pro His Lys Ala Ser Cys Val Asn Ala Leu Glu Gly Lys
                 165                 170                 175    
 Lys Leu Ala Gln Asp Val Arg Ala Arg Gly Tyr Leu Glu Cys Ser Ala
             180                 185                 190        
 Leu Ser Asn Arg Gly Val Gln Gln Val Phe Glu Cys Ala Val Arg Glu
         195                 200                 205            
 Thr Ala Val Asn Gln Ala Arg Arg Arg Asn Arg Arg Arg Leu Phe Ser
     210                 215                 220                
 Ile Asn Glu Cys Lys Ile Phe
 225                 230    



      <210> 748
      <211> 53
      <212> PRT
      <213> Homo sapiens


      <400> 748
 Ser Leu Arg Gly Glu Gln Leu Arg Pro Trp Ala Pro Gly Asp Leu Ser
   1               5                  10                  15    
 Val Met Ser Phe Arg Asp Leu Arg Ser Lys Ala Ala Pro Arg Pro Cys
              20                  25                  30        
 Asp Leu Arg Val Phe Gln Arg Phe Arg Ala Pro Ala Arg Arg Val Pro
          35                  40                  45            
 Cys Val Gly Asp Pro
      50            



      <210> 749
      <211> 423
      <212> PRT
      <213> Homo sapiens


      <400> 749
 Gly Gly Ser Ser Val Ile Phe Tyr Gly Leu Ile Cys Met Tyr Thr Leu
   1               5                  10                  15    
 Trp Trp Met Leu Arg Ala Ser Leu Lys Lys Tyr Ser Phe Glu Ser Ile
              20                  25                  30        
 Arg Glu Glu Ser Ser Tyr Ser Asp Ile Pro Asp Val Lys Asn Asp Phe
          35                  40                  45            
 Ala Phe Met Leu His Leu Ile Asp Gln Tyr Asp Pro Leu Tyr Ser Lys
      50                  55                  60                
 Arg Phe Ala Val Phe Leu Ser Glu Val Ser Glu Asn Lys Leu Arg Gln
  65                  70                  75                  80
 Leu Asn Leu Asn Asn Glu Trp Thr Leu Asp Lys Leu Arg Gln Arg Leu
                  85                  90                  95    
 Thr Lys Asn Ala Gln Asp Lys Leu Glu Leu His Leu Phe Met Leu Ser
             100                 105                 110        
 Gly Ile Pro Asp Thr Val Phe Asp Leu Val Glu Leu Glu Val Leu Lys
         115                 120                 125            
 Leu Glu Leu Ile Pro Asp Val Thr Ile Pro Pro Ser Ile Ala Gln Leu
     130                 135                 140                
 Thr Gly Leu Lys Glu Leu Trp Leu Tyr His Thr Ala Ala Lys Ile Glu
 145                 150                 155                 160
 Ala Pro Ala Leu Ala Phe Leu Arg Glu Asn Leu Arg Ala Leu His Ile
                 165                 170                 175    
 Lys Phe Thr Asp Ile Lys Glu Ile Pro Leu Trp Ile Tyr Ser Leu Lys
             180                 185                 190        
 Thr Leu Glu Glu Leu His Leu Thr Gly Asn Leu Ser Ala Glu Asn Asn
         195                 200                 205            
 Arg Tyr Ile Val Ile Asp Gly Leu Arg Glu Leu Lys Arg Leu Lys Val
     210                 215                 220                
 Leu Arg Leu Lys Ser Asn Leu Ser Lys Leu Pro Gln Val Val Thr Asp
 225                 230                 235                 240
 Val Gly Val His Leu Gln Lys Leu Ser Ile Asn Asn Glu Gly Thr Lys
                 245                 250                 255    
 Leu Ile Leu Trp Tyr Asn His Ile Ala Tyr Ile Pro Ile Gln Ile Gly
             260                 265                 270        
 Asn Leu Thr Asn Leu Glu Arg Leu Tyr Leu Asn Arg Asn Lys Ile Glu
         275                 280                 285            
 Lys Ile Pro Thr Gln Leu Phe Tyr Cys Arg Lys Leu Arg Tyr Leu Asp
     290                 295                 300                
 Leu Ser His Asn Asn Leu Thr Phe Leu Pro Ala Asp Ile Gly Leu Leu
 305                 310                 315                 320
 Gln Asn Leu Gln Asn Leu Ala Ile Thr Ala Asn Arg Ile Glu Thr Leu
                 325                 330                 335    
 Pro Pro Glu Leu Phe Gln Cys Arg Lys Leu Arg Ala Leu His Leu Gly
             340                 345                 350        
 Asn Asn Val Leu Gln Ser Leu Pro Ser Arg Val Gly Glu Leu Thr Asn
         355                 360                 365            
 Leu Thr Gln Ile Glu Leu Arg Gly Asn Arg Leu Glu Cys Leu Pro Val
     370                 375                 380                
 Glu Leu Gly Glu Cys Pro Leu Leu Lys Arg Ser Gly Leu Val Val Glu
 385                 390                 395                 400
 Glu Asp Leu Phe Asn Thr Leu Pro Pro Glu Val Lys Glu Arg Leu Trp
                 405                 410                 415    
 Arg Ala Asp Lys Glu Gln Ala
             420            



      <210> 750
      <211> 445
      <212> PRT
      <213> Homo sapiens


      <400> 750
 Arg Arg Gly Val Ser Gly Ala Arg Val Arg Val Ala Phe Gln Gly Asn
   1               5                  10                  15    
 Glu Arg Gly Ser Lys Trp Ala Ala Arg Gly Gly Ala Arg Asp Ala Gly
              20                  25                  30        
 Gly Arg Gly Arg Ser Gly Leu Trp Lys Gly Pro Lys Leu Met Arg Arg
          35                  40                  45            
 Ala Pro Ala Ala Glu Arg Leu Leu Glu Leu Gly Phe Pro Pro Arg Cys
      50                  55                  60                
 Gly Arg Gln Glu Pro Pro Phe Pro Leu Gly Val Thr Arg Gly Trp Gly
  65                  70                  75                  80
 Arg Trp Pro Ile Gln Lys Arg Arg Glu Gly Ala Arg Pro Val Pro Phe
                  85                  90                  95    
 Ser Glu Arg Ser Gln Glu Asp Gly Arg Gly Pro Ala Ala Arg Ser Ser
             100                 105                 110        
 Gly Thr Leu Trp Arg Ile Arg Thr Arg Leu Ser Leu Cys Arg Asp Pro
         115                 120                 125            
 Glu Pro Pro Pro Pro Leu Cys Leu Leu Arg Val Ser Leu Leu Cys Ala
     130                 135                 140                
 Leu Arg Ala Gly Gly Arg Gly Ser Arg Trp Gly Glu Asp Gly Ala Arg
 145                 150                 155                 160
 Leu Leu Leu Leu Pro Pro Ala Arg Ala Ala Gly Asn Gly Glu Ala Glu
                 165                 170                 175    
 Pro Ser Gly Gly Pro Ser Tyr Ala Gly Arg Met Leu Glu Ser Ser Gly
             180                 185                 190        
 Cys Lys Ala Leu Lys Glu Gly Val Leu Glu Lys Arg Ser Asp Gly Leu
         195                 200                 205            
 Leu Gln Leu Trp Lys Lys Lys Cys Cys Ile Leu Thr Glu Glu Gly Leu
     210                 215                 220                
 Leu Leu Ile Pro Pro Lys Gln Leu Gln His Gln Gln Gln Gln Gln Gln
 225                 230                 235                 240
 Gln Gln Gln Gln Gln Gln Gln Gln Pro Gly Gln Gly Pro Ala Glu Pro
                 245                 250                 255    
 Ser Gln Pro Ser Gly Pro Ala Val Ala Ser Leu Glu Pro Pro Val Lys
             260                 265                 270        
 Leu Lys Glu Leu Leu Phe Ser Asn Met Lys Thr Val Asp Cys Val Glu
         275                 280                 285            
 Arg Lys Gly Lys Tyr Met Tyr Phe Thr Val Val Met Ala Glu Gly Lys
     290                 295                 300                
 Glu Ile Asp Phe Arg Cys Pro Gln Asp Gln Gly Trp Asn Ala Glu Ile
 305                 310                 315                 320
 Thr Leu Gln Met Val Gln Tyr Lys Asn Arg Gln Ala Ile Leu Ala Val
                 325                 330                 335    
 Lys Ser Thr Arg Gln Lys Gln Gln His Leu Val Gln Gln Gln Pro Pro
             340                 345                 350        
 Ser Gln Pro Gln Pro Gln Pro Gln Leu Gln Pro Gln Pro Gln Pro Gln
         355                 360                 365            
 Pro Gln Pro Gln Pro Gln Pro Gln Ser Gln Pro Gln Pro Gln Pro Gln
     370                 375                 380                
 Pro Lys Pro Gln Pro Gln Gln Leu His Pro Tyr Pro His Pro His Pro
 385                 390                 395                 400
 His Pro His Ser His Pro His Ser His Pro His Pro His Pro His Pro
                 405                 410                 415    
 His Pro His Gln Ile Pro His Pro His Pro Gln Pro His Ser Gln Pro
             420                 425                 430        
 His Gly His Arg Leu Leu Arg Ser Thr Ser Asn Ser Ala
         435                 440                 445



      <210> 751
      <211> 60
      <212> PRT
      <213> Homo sapiens


      <400> 751
 Lys Met Thr Glu Pro Gly Ala Ser Pro Glu Asp Leu Trp Val Lys Val
   1               5                  10                  15    
 Glu Tyr Ala Tyr Ser Asp Asn Ser Leu Asp Pro Asp Pro Ala Gly Asp
              20                  25                  30        
 Cys Asp Trp Arg Pro Ala Pro Ile Glu Lys Pro Ala Leu Leu Thr Gly
          35                  40                  45            
 Ser Trp Lys Pro Gly Glu Gln Pro Thr Arg Gly Pro
      50                  55                  60



      <210> 752
      <211> 60
      <212> PRT
      <213> Homo sapiens


      <400> 752
 Lys Met Thr Glu Pro Gly Ala Ser Pro Glu Asp Leu Trp Val Lys Val
   1               5                  10                  15    
 Glu Tyr Ala Tyr Ser Asp Asn Ser Leu Asp Pro Asp Pro Ala Gly Asp
              20                  25                  30        
 Cys Asp Trp Arg Pro Ala Pro Ile Glu Lys Pro Ala Leu Leu Thr Gly
          35                  40                  45            
 Ser Trp Lys Pro Gly Glu Gln Pro Thr Arg Gly Pro
      50                  55                  60



      <210> 753
      <211> 60
      <212> PRT
      <213> Homo sapiens


      <400> 753
 Lys Met Thr Glu Pro Gly Ala Ser Pro Glu Asp Leu Trp Val Lys Val
   1               5                  10                  15    
 Glu Tyr Ala Tyr Ser Asp Asn Ser Leu Asp Pro Asp Pro Ala Gly Asp
              20                  25                  30        
 Cys Asp Trp Arg Pro Ala Pro Ile Glu Lys Pro Ala Leu Leu Thr Gly
          35                  40                  45            
 Ser Trp Lys Pro Gly Glu Gln Pro Thr Arg Gly Pro
      50                  55                  60



      <210> 754
      <211> 60
      <212> PRT
      <213> Homo sapiens


      <400> 754
 Lys Met Thr Glu Pro Gly Ala Ser Pro Glu Asp Leu Trp Val Lys Val
   1               5                  10                  15    
 Glu Tyr Ala Tyr Ser Asp Asn Ser Leu Asp Pro Asp Pro Ala Gly Asp
              20                  25                  30        
 Cys Asp Trp Arg Pro Ala Pro Ile Glu Lys Pro Ala Leu Leu Thr Gly
          35                  40                  45            
 Ser Trp Lys Pro Gly Glu Gln Pro Thr Arg Gly Pro
      50                  55                  60



      <210> 755
      <211> 559
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(559)
      <223> Xaa = any amino acid or nothing 


      <400> 755
 Xaa Lys Leu Ser Arg Glu Cys Glu Ile Lys Tyr Thr Gly Phe Arg Asp
   1               5                  10                  15    
 Arg Pro His Glu Glu Arg Gln Ala Arg Phe Gln Asn Ala Cys Arg Asp
              20                  25                  30        
 Gly Arg Ser Glu Ile Ala Phe Val Ala Thr Gly Thr Asn Leu Ser Leu
          35                  40                  45            
 Gln Phe Phe Pro Ala Ser Trp Gln Gly Glu Gln Arg Gln Thr Pro Ser
      50                  55                  60                
 Arg Glu Tyr Val Asp Leu Glu Arg Glu Ala Gly Lys Val Tyr Leu Lys
  65                  70                  75                  80
 Ala Pro Met Ile Leu Asn Gly Val Cys Val Ile Trp Lys Gly Trp Ile
                  85                  90                  95    
 Asp Leu Gln Arg Leu Asp Gly Met Gly Cys Leu Glu Phe Asp Glu Glu
             100                 105                 110        
 Arg Ala Gln Gln Glu Asp Ala Leu Ala Gln Gln Ala Phe Glu Glu Ala
         115                 120                 125            
 Arg Arg Arg Thr Arg Glu Phe Glu Asp Arg Asp Arg Ser His Arg Glu
     130                 135                 140                
 Glu Met Glu Val His Glu Leu Glu Lys Ser Lys Arg Ala Leu Glu Thr
 145                 150                 155                 160
 Gln Met Glu Glu Met Lys Thr Gln Leu Glu Glu Leu Glu Asp Glu Leu
                 165                 170                 175    
 Gln Ala Ser Glu Asp Ala Lys Leu Arg Leu Glu Val Asn Met Gln Ala
             180                 185                 190        
 Leu Lys Gly Gln Phe Glu Arg Asp Leu Gln Ala Arg Asp Glu Gln Asn
         195                 200                 205            
 Glu Glu Lys Arg Arg Gln Leu Gln Arg Gln Leu His Glu Tyr Glu Thr
     210                 215                 220                
 Glu Leu Glu Asp Glu Arg Asn Glu Arg Ala Leu Ala Ala Ala Ala Lys
 225                 230                 235                 240
 Lys Lys Leu Glu Gly Asp Leu Lys Asp Leu Glu Leu Gln Ala Asp Ser
                 245                 250                 255    
 Ala Ile Lys Gly Arg Glu Glu Ala Ile Lys Gln Leu Arg Lys Leu Gln
             260                 265                 270        
 Ala Gln Met Lys Asp Phe Gln Arg Glu Leu Glu Asp Ala Arg Ala Ser
         275                 280                 285            
 Arg Asp Glu Ile Phe Ala Thr Ala Lys Glu Asn Glu Lys Lys Ala Lys
     290                 295                 300                
 Ser Leu Glu Ala Asp Leu Met Gln Leu Gln Glu Asp Leu Ala Ala Ala
 305                 310                 315                 320
 Glu Arg Ala Arg Lys Gln Ala Asp Leu Glu Lys Glu Glu Leu Ala Glu
                 325                 330                 335    
 Glu Leu Ala Ser Ser Leu Ser Gly Arg Asn Ala Leu Gln Asp Glu Lys
             340                 345                 350        
 Arg Arg Leu Glu Ala Arg Ile Ala Gln Leu Glu Glu Glu Leu Glu Glu
         355                 360                 365            
 Glu Gln Gly Asn Met Glu Ala Met Ser Asp Arg Val Arg Lys Ala Thr
     370                 375                 380                
 Gln Gln Ala Glu Gln Leu Ser Asn Glu Leu Ala Thr Glu Arg Ser Thr
 385                 390                 395                 400
 Ala Gln Lys Asn Glu Ser Ala Arg Gln Gln Leu Glu Arg Gln Asn Lys
                 405                 410                 415    
 Glu Leu Arg Ser Lys Leu His Glu Met Glu Gly Ala Val Lys Ser Lys
             420                 425                 430        
 Phe Lys Ser Thr Ile Ala Ala Leu Glu Ala Lys Ile Ala Gln Leu Glu
         435                 440                 445            
 Glu Gln Val Glu Gln Glu Ala Arg Glu Lys Gln Ala Ala Thr Lys Ser
     450                 455                 460                
 Leu Lys Gln Lys Asp Lys Lys Leu Lys Glu Ile Leu Leu Gln Val Glu
 465                 470                 475                 480
 Asp Glu Arg Lys Met Ala Glu Gln Tyr Lys Glu Gln Ala Glu Lys Gly
                 485                 490                 495    
 Asn Ala Arg Val Lys Gln Leu Lys Arg Gln Leu Glu Glu Ala Glu Glu
             500                 505                 510        
 Glu Ser Gln Arg Ile Asn Ala Asn Arg Arg Lys Leu Gln Arg Glu Leu
         515                 520                 525            
 Asp Glu Ala Thr Glu Ser Asn Glu Ala Met Gly Arg Glu Val Asn Ala
     530                 535                 540                
 Leu Lys Ser Lys Leu Arg Gly Pro Pro Pro Gln Glu Thr Ser Gln
 545                 550                 555                



      <210> 756
      <211> 41
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(41)
      <223> Xaa = any amino acid or nothing 


      <400> 756
 Leu Lys Arg Gln Ala Asn Thr Phe Pro Ile Leu Ser Xaa Thr Lys Asn
   1               5                  10                  15    
 Thr His Asn Val Ala Phe Leu Leu Gly Lys Thr Cys Phe Leu Tyr Phe
              20                  25                  30        
 Thr Xaa Glu Cys Asn Ile Thr Leu Pro
          35                  40    



      <210> 757
      <211> 163
      <212> PRT
      <213> Homo sapiens


      <400> 757
 Gly Gly Ile Pro Arg Val Phe Leu Tyr Glu Leu Leu Pro Glu Ser Pro
   1               5                  10                  15    
 Phe Phe Leu Glu Cys Asn Ser Phe Thr Ser Pro Asp Pro His Lys Gly
              20                  25                  30        
 Leu Val Leu Leu Pro Lys Thr Glu Cys Asp Val Arg Glu Val Glu Leu
          35                  40                  45            
 Met Arg Cys Leu Arg Leu Arg Gln Ser Ser Leu Glu Pro Val Ala Phe
      50                  55                  60                
 Arg Leu Pro Arg Val Arg Lys Glu Phe Phe Gln Asp Asp Val Phe Pro
  65                  70                  75                  80
 Asp Thr Ala Val Ile Trp Glu Pro Val Leu Ser Ala Glu Ala Trp Leu
                  85                  90                  95    
 Gln Gly Ala Asn Gly Gln Pro Trp Leu Leu Ser Leu Gln Pro Pro Asp
             100                 105                 110        
 Met Ser Pro Gly Ala Pro Arg Asp Trp Val Trp Gly Gly Ser Gly Met
         115                 120                 125            
 Gly Val Gly Glu Arg Asp Arg Arg Pro Arg Leu Lys Phe His Ser Cys
     130                 135                 140                
 Trp His Ala Glu Ser Ser Gly Leu Trp Glu Gly Gly Val Ala Val Ser
 145                 150                 155                 160
 Ile Ser Leu
            



      <210> 758
      <211> 272
      <212> PRT
      <213> Homo sapiens


      <400> 758
 Met Val Pro Asp Glu Arg Tyr Ile Thr Gln Glu Gly His Lys Leu Glu
   1               5                  10                  15    
 Thr Gly Ala Pro Arg Pro Pro Ala Thr Val Thr Asn Ala Val Ser Trp
              20                  25                  30        
 Arg Ser Glu Gly Ile Lys Tyr Arg Lys Asn Glu Val Phe Leu Asp Val
          35                  40                  45            
 Ile Glu Ser Val Asn Leu Leu Gln Leu Glu Val Thr Phe Phe Ala Gly
      50                  55                  60                
 Glu Lys Arg Phe Glu Thr Glu Thr Pro Thr Val Ser Leu Thr Leu Ser
  65                  70                  75                  80
 Cys Gly Asn Pro Arg Leu Ile Val Ala Arg Ala Thr Pro Pro Pro Phe
                  85                  90                  95    
 Leu Glu Gln Leu Ser Gln Ser Lys Arg Ser Glu Ala Ala Ile Arg Ala
             100                 105                 110        
 Glu Ile Val Phe Ala Asn Arg Lys Cys Gly Thr Pro Ala Thr Glu Ala
         115                 120                 125            
 Leu Glu Ser Val Met Glu Ala Tyr Glu Gln Val Gln Lys Gly Pro Leu
     130                 135                 140                
 Lys Leu Lys Gly Phe Ala Glu Leu Gly Val Thr Lys Arg Lys Lys Lys
 145                 150                 155                 160
 Lys Lys Asp Lys Asp Lys Ala Lys Leu Leu Glu Ala Met Gly Thr Ser
                 165                 170                 175    
 Lys Lys Asn Glu Glu Glu Lys Arg Arg Gly Leu Asp Lys Arg Thr Pro
             180                 185                 190        
 Ala Gln Ala Ala Phe Glu Lys Met Gln Glu Lys Arg Val Leu Ile Cys
         195                 200                 205            
 Arg Asn Tyr Arg Gly Asp Val Asp Met Ser Glu Val Glu His Phe Met
     210                 215                 220                
 Pro Ile Leu Met Glu Lys Glu Glu Glu Gly Met Leu Ser Pro Ile Leu
 225                 230                 235                 240
 Ala His Gly Gly Val Arg Phe Met Trp Ile Lys His Asn Asn Leu Tyr
                 245                 250                 255    
 Arg Ile Pro Leu Leu Gly Val Leu Pro Gly Asp Ser Cys Val Gly Val
             260                 265                 270        





      <210> 759
      <211> 328
      <212> PRT
      <213> Homo sapiens


      <400> 759
 Thr Pro Ala Pro Ala Glu Ala Glu Gln Gly Lys Ser Gln Cys Pro Ser
   1               5                  10                  15    
 Gly Ser Thr Ala Gln Ser Trp Ser Ala Met Asp Ile Leu Val Pro Leu
              20                  25                  30        
 Leu Gln Leu Leu Val Leu Leu Leu Thr Leu Pro Leu His Leu Met Ala
          35                  40                  45            
 Leu Leu Gly Cys Trp Gln Pro Leu Cys Lys Ser Tyr Phe Pro Tyr Leu
      50                  55                  60                
 Met Ala Val Leu Thr Pro Lys Ser Asn Arg Lys Met Glu Ser Lys Lys
  65                  70                  75                  80
 Arg Glu Leu Phe Ser Gln Ile Lys Gly Leu Thr Gly Pro Pro Gly Lys
                  85                  90                  95    
 Val Ala Leu Leu Glu Leu Gly Cys Gly Thr Gly Gly Asn Phe Gln Phe
             100                 105                 110        
 Tyr Pro Pro Gly Cys Arg Val Thr Cys Leu Asp Pro Asn Pro His Phe
         115                 120                 125            
 Glu Lys Phe Leu Thr Lys Ser Met Ala Glu Asn Arg His Leu Gln Tyr
     130                 135                 140                
 Glu Arg Phe Val Val Ala Pro Gly Glu Asp Met Arg Gln Leu Ala Asp
 145                 150                 155                 160
 Gly Ser Met Asp Val Val Val Cys Thr Leu Val Leu Cys Ser Val Gln
                 165                 170                 175    
 Ser Pro Arg Lys Val Leu Gln Glu Val Arg Arg Val Leu Arg Pro Gly
             180                 185                 190        
 Gly Val Leu Phe Phe Trp Glu His Val Ala Glu Pro Tyr Gly Ser Trp
         195                 200                 205            
 Ala Phe Met Trp Gln Gln Val Phe Glu Pro Thr Trp Lys His Ile Gly
     210                 215                 220                
 Glu Gly Cys Cys Leu Thr Gln Lys Thr Trp Lys Asp Leu Glu Lys Ala
 225                 230                 235                 240
 Gln Phe Ser Glu Asn Gln Arg Glu Arg Gln Ala Pro Ser Leu Lys Gly
                 245                 250                 255    
 Pro Thr Leu Trp Ala Pro Pro Ser Leu Glu Arg Gly Cys Lys Lys Phe
             260                 265                 270        
 Phe Pro Arg Asp Gly Glu Gln Glu Thr Gly Ala Leu Gln Pro Asp Lys
         275                 280                 285            
 Gly Ala Tyr Arg Ser Leu Arg Glu Ser Gly Pro Thr Gly Ala Gly Leu
     290                 295                 300                
 Arg Asn Arg Ser Gln Leu Ser Val Leu Pro Thr Gly Leu Gln Gly His
 305                 310                 315                 320
 Leu Pro Arg Pro Lys Ser Pro Leu
                 325            



      <210> 760
      <211> 67
      <212> PRT
      <213> Homo sapiens


      <400> 760
 Gln Leu Pro Asp Pro Ala Ile Glu Asp Gln Gly Gly Glu Tyr Val Gln
   1               5                  10                  15    
 Pro Met Leu Ser Lys Tyr Ala Ala Val Cys Val Arg Cys Pro Gly Tyr
              20                  25                  30        
 Gly Thr Arg Gly Pro Ala Lys Lys Pro Ser Ala His Ser Gln Ser Gln
          35                  40                  45            
 Ala Ser Ser Ser Pro Glu Trp Ile Pro Glu Leu Leu Pro Cys Pro Asp
      50                  55                  60                
 Ala Ala Ala
  65        



      <210> 761
      <211> 31
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(31)
      <223> Xaa = any amino acid or nothing 


      <400> 761
 Phe Ile Thr Ser Leu Gly His Arg Cys Leu Ile Tyr Lys Ile Ser Cys
   1               5                  10                  15    
 Gln Ile Ser Lys Ile Ala Xaa Asn Thr Phe Val Ser His Leu Met
              20                  25                  30    



      <210> 762
      <211> 97
      <212> PRT
      <213> Homo sapiens


      <400> 762
 Pro Thr Thr Leu Ser Asp Trp Leu Ala Gly Tyr Val Phe Leu Ser Ser
   1               5                  10                  15    
 Gln Leu Cys Gly Gln Cys His Thr Pro Ser Trp Thr Thr Thr Ala Leu
              20                  25                  30        
 Ala Cys Ile Phe Gln Cys Cys Phe Cys Gln Arg Gly Gln Gln Ser His
          35                  40                  45            
 Gly Ser Ser Arg Thr Ser Pro Glu Leu Ser Glu Glu Cys Pro Gly Glu
      50                  55                  60                
 Met Val Lys Met Thr Lys Ser Lys Thr Phe Gln Ala Tyr Leu Pro Asn
  65                  70                  75                  80
 Cys His Arg Thr Tyr Ser Cys Ile His Cys Arg Ala His Leu Ala Asn
                  85                  90                  95    
 His
    



      <210> 763
      <211> 29
      <212> PRT
      <213> Homo sapiens


      <400> 763
 Met Asp Ser Ser Ile Arg Gly Ser Leu Ala Arg Leu Cys Lys Gly Leu
   1               5                  10                  15    
 Gln Ala Cys Cys Tyr Met Phe Asn Trp Ala Pro Gln Val
              20                  25                



      <210> 764
      <211> 228
      <212> PRT
      <213> Homo sapiens


      <400> 764
 Ala Arg Gly Asp Ala Ser Glu Phe Ser Lys Asn Pro His Ile Gly Ser
   1               5                  10                  15    
 Phe Val Gly Asn Gln Val Thr Ile Arg Lys Ala Asp Gly Ser Leu Val
              20                  25                  30        
 His Ile Ser Ile Thr Pro Tyr Pro Ala Ile Leu His Glu Tyr Val Ser
          35                  40                  45            
 Ser Ser Lys Trp Glu Asp Ala Val Arg Leu Cys Arg Phe Val Lys Glu
      50                  55                  60                
 Gln Thr Met Trp Ala Cys Leu Ala Ala Met Ala Ala Ala Asn Arg Asp
  65                  70                  75                  80
 Met Thr Thr Ala Glu Ile Ala Tyr Ala Ala Ile Gly Glu Ile Asp Lys
                  85                  90                  95    
 Val Gln Tyr Ile Asn Ser Ile Lys Asn Leu Pro Ser Lys Glu Ser Lys
             100                 105                 110        
 Met Ala His Ile Leu Leu Leu Ser Gly Asn Ile Gln Glu Ala Glu Ile
         115                 120                 125            
 Val Leu Leu Gln Ala Gly Leu Cys Tyr Gln Ala Ile Gln Ile Asn Ile
     130                 135                 140                
 Asn Leu Tyr His Trp Glu Arg Ala Leu Glu Leu Ala Val Gln His Lys
 145                 150                 155                 160
 Thr His Val Asp Thr Val Leu Ala Tyr Arg Gln Lys Phe Leu Glu Thr
                 165                 170                 175    
 Phe Gly Leu Gln Glu Thr Asn Lys Arg Tyr Leu His Tyr Ala Lys Gly
             180                 185                 190        
 Leu Pro Ile Tyr Trp Glu Lys Ser Lys Ala Thr Ile Glu Met Glu Ile
         195                 200                 205            
 Thr Gln Glu Arg Glu His Phe Leu Arg Ser Gln Ser Ser Lys Ser Ile
     210                 215                 220                
 Gly Leu Lys Pro
 225            



      <210> 765
      <211> 59
      <212> PRT
      <213> Homo sapiens


      <400> 765
 Glu Phe Leu His Met Ala Pro Gly Glu Val Thr Ile Thr Val Arg Leu
   1               5                  10                  15    
 Ile Arg Ser Phe Glu His Arg Asn Phe Lys Pro Val Val Tyr His Gly
              20                  25                  30        
 Val Asn Leu Asp Gln Thr Val Lys Glu Phe Ile Val Phe Leu Lys Gln
          35                  40                  45            
 Asp Ala Leu Lys Ile Ile His Gln Ala His Lys
      50                  55                



      <210> 766
      <211> 595
      <212> PRT
      <213> Homo sapiens


      <400> 766
 Glu His Asp Leu His Tyr Ala Lys Leu Gly Thr Arg Ala Thr Gly Gly
   1               5                  10                  15    
 Gly Gly Arg Gly Pro Ser Gly His Asn Val Phe Leu Asp Glu Gly Gly
              20                  25                  30        
 Thr Pro Leu Leu Ala Glu Ser Leu Val Tyr Gln Ile Phe Leu Ser Leu
          35                  40                  45            
 Gly Leu Ala Asp Leu Leu Ala Ala Gly Leu Val Cys Arg Gln Trp Gln
      50                  55                  60                
 Ala Val Ser Arg Asp Glu Phe Leu Trp Arg Glu Gln Phe Tyr Arg Tyr
  65                  70                  75                  80
 Tyr Gln Val Ala Arg Asp Val Pro Arg His Pro Ala Ala Met Ser Trp
                  85                  90                  95    
 Tyr Glu Glu Phe Gln Arg Leu Tyr Asp Thr Val Pro Cys Val Glu Val
             100                 105                 110        
 Gln Thr Leu Arg Glu His Thr Asp Gln Val Leu His Leu Ser Phe Ser
         115                 120                 125            
 His Ser Gly Tyr Gln Phe Ala Ser Cys Ser Lys Asp Cys Thr Val Asn
     130                 135                 140                
 Ile Trp Ser Asn Asp Leu Thr Ile Ser Leu Leu His Ser Ala Asp Met
 145                 150                 155                 160
 Arg Pro Tyr Asn Trp Ser Tyr Thr Gln Phe Ser Gln Phe Asn Lys Asp
                 165                 170                 175    
 Asp Ser Leu Leu Leu Ala Ser Gly Val Phe Leu Gly Pro His Asn Ser
             180                 185                 190        
 Ser Ser Gly Glu Ile Ala Val Ile Ser Leu Asp Ser Phe Ala Leu Leu
         195                 200                 205            
 Ser Arg Val Arg Asn Lys Pro Tyr Asp Val Phe Gly Cys Trp Leu Thr
     210                 215                 220                
 Glu Thr Ser Leu Ile Ser Gly Asn Leu His Arg Ile Gly Asp Ile Thr
 225                 230                 235                 240
 Ser Cys Ser Val Leu Trp Leu Asn Asn Ala Phe Gln Asp Val Glu Ser
                 245                 250                 255    
 Glu Asn Val Asn Val Val Lys Arg Leu Phe Lys Ile Gln Asn Leu Asn
             260                 265                 270        
 Ala Ser Thr Val Arg Thr Val Met Val Ala Asp Cys Ser Arg Phe Asp
         275                 280                 285            
 Ser Pro Asp Leu Leu Leu Glu Ala Gly Asp Pro Ala Thr Ser Pro Cys
     290                 295                 300                
 Arg Ile Phe Asp Leu Gly Ser Asp Asn Glu Glu Gly Trp Leu Cys Ser
 305                 310                 315                 320
 Pro Pro Ala His Ala Lys Glu Gly Leu Arg His Phe Leu Asp Arg Val
                 325                 330                 335    
 Leu Glu Gly Arg Ala Gln Pro Gln Leu Ser Glu Arg Met Leu Glu Thr
             340                 345                 350        
 Lys Val Ala Glu Leu Leu Ala Gln Gly His Thr Lys Pro Pro Glu Arg
         355                 360                 365            
 Ser Ala Thr Gly Ala Lys Ser Lys Tyr Leu Ile Phe Thr Thr Gly Cys
     370                 375                 380                
 Leu Thr Tyr Ser Pro His Gln Ile Gly Ile Lys Gln Ile Leu Pro His
 385                 390                 395                 400
 Gln Met Thr Thr Ala Gly Pro Val Leu Gly Glu Gly Arg Gly Ser Asp
                 405                 410                 415    
 Ala Phe Phe Asp Arg Arg Leu Asp His Val Ile Asp Ile His Gly His
             420                 425                 430        
 Ile Ile Gly Met Gly Leu Ser Pro Asp Asn Arg Tyr Leu Tyr Val Asn
         435                 440                 445            
 Ser Arg Ala Trp Pro Asn Gly Ser Val Val Ala Asp Pro Met Gln Pro
     450                 455                 460                
 Pro Pro Ile Ala Glu Glu Ile Asp Leu Leu Val Phe Asp Leu Lys Thr
 465                 470                 475                 480
 Met Arg Glu Val Arg Arg Ala Leu Arg Ala His Arg Ala Tyr Thr Pro
                 485                 490                 495    
 Asn Asp Glu Cys Phe Phe Ile Phe Leu Asp Val Ser Arg Asp Phe Val
             500                 505                 510        
 Ala Ser Gly Ala Glu Asp Arg His Gly Tyr Ile Trp Asp Arg His Tyr
         515                 520                 525            
 Asn Ile Cys Leu Ala Arg Leu Arg His Glu Asp Val Val Asn Ser Val
     530                 535                 540                
 Val Phe Ser Pro Gln Gly Ala Arg Arg Cys Cys Phe Thr Ala Lys Gly
 545                 550                 555                 560
 His Ala Thr Ile Lys Ser Trp Arg Ser Pro Arg Thr Met Gly Val Leu
                 565                 570                 575    
 Gln Ala Pro Arg Pro Arg Pro Arg Thr Phe Phe Ser Trp Leu Ala Ser
             580                 585                 590        
 Gln Arg Arg
         595



      <210> 767
      <211> 34
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(34)
      <223> Xaa = any amino acid or nothing 


      <400> 767
 Met Gly Ser Met Val Val Gly Val Val Val Ser Ala Phe Leu Phe Thr
   1               5                  10                  15    
 Pro Phe Phe Val Phe Thr Gly Cys Gly Val Ala Ala Met Met Gly Xaa
              20                  25                  30        
 Val Ala
        



      <210> 768
      <211> 110
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(110)
      <223> Xaa = any amino acid or nothing 


      <400> 768
 Arg Arg Cys Lys Val Arg Pro Ser Ala Arg Gly Val Leu Arg Tyr Ala
   1               5                  10                  15    
 Val Cys Val Cys Val Cys Val Cys Val Tyr Pro Cys Val His Val Cys
              20                  25                  30        
 Thr Cys Val Arg Met Cys Leu Cys Val Cys Val Cys Val Cys Glu Ala
          35                  40                  45            
 Gln Trp Arg Phe Thr Val Gly Val Arg Asp Val His Ala Ala Phe Ala
      50                  55                  60                
 Ser Ser Pro Lys Lys Gly Gly Ala Leu Ser Arg Leu Trp Leu Cys Thr
  65                  70                  75                  80
 Val Pro Pro Ser Ser Gly Gly Thr Gly Leu Ser Xaa Xaa Ser Ser Leu
                  85                  90                  95    
 Trp Pro Gly Ser Asp Gly Ile Ser Ala Thr Thr Pro Cys Cys
             100                 105                 110



      <210> 769
      <211> 33
      <212> PRT
      <213> Homo sapiens


      <400> 769
 Ile Asn Pro Ser Thr Ser His Leu Pro His Ser Gly Ala Pro Glu Pro
   1               5                  10                  15    
 Trp Thr Met Ile His Pro Phe Glu Leu Phe Leu Val Leu Lys Cys Val
              20                  25                  30        
 Val
    



      <210> 770
      <211> 61
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(61)
      <223> Xaa = any amino acid or nothing 


      <400> 770
 Asp Ala Asp Ser Met Cys Glu Leu Pro Ser Asp Leu Gln Gln Ser Cys
   1               5                  10                  15    
 Gln His Ala Val Ser Asp Ser Asp Thr Gln Ala Trp Cys Pro Arg Arg
              20                  25                  30        
 Pro Gly Ser Leu Cys Gly Thr Gly Arg Arg Ala Pro Gly Ser Xaa Gly
          35                  40                  45            
 Gly Ser Arg Val Ile Asp Arg Gly Arg Pro Leu Ala Ile
      50                  55                  60    



      <210> 771
      <211> 61
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(61)
      <223> Xaa = any amino acid or nothing 


      <400> 771
 Asp Ala Asp Ser Met Cys Glu Leu Pro Ser Asp Leu Gln Gln Ser Cys
   1               5                  10                  15    
 Gln His Ala Val Ser Asp Ser Asp Thr Gln Ala Trp Cys Pro Arg Arg
              20                  25                  30        
 Pro Gly Ser Leu Cys Gly Thr Gly Arg Arg Ala Pro Gly Ser Xaa Gly
          35                  40                  45            
 Gly Ser Arg Val Ile Asp Arg Gly Arg Pro Leu Ala Ile
      50                  55                  60    



      <210> 772
      <211> 85
      <212> PRT
      <213> Homo sapiens


      <400> 772
 Ser Thr Glu Gln Gln Arg Arg Ser Ala Arg Arg Ala Gly Ala His Gly
   1               5                  10                  15    
 Pro Phe Pro Thr Ala Ser Ala Ser Ala Gly Pro Thr Pro Arg Gly Arg
              20                  25                  30        
 Gly Arg Pro Leu Phe Pro Gly Leu Arg Ala Glu Val Asp Glu Phe Glu
          35                  40                  45            
 Ser Cys Gly Pro Leu Asn Val Ala Ala Arg Gly Arg Arg Ala Pro Thr
      50                  55                  60                
 Tyr Ser Gly Pro Gly Lys Val Ala Leu Arg Leu Trp Asn Phe Cys Pro
  65                  70                  75                  80
 Ala Leu Leu Gly Glu
                  85



      <210> 773
      <211> 139
      <212> PRT
      <213> Homo sapiens


      <400> 773
 Tyr Ala Thr Leu Gly Thr Arg Gln Gln Ile Glu Val Ala Arg Gln Leu
   1               5                  10                  15    
 Ile Asp Glu Lys Val Gly Gly Thr Asn Leu Gly Ala Pro Gly Ala Phe
              20                  25                  30        
 Gly Gln Ser Pro Phe Ser Gln Pro Pro Ala Pro Pro His Gln Asn Thr
          35                  40                  45            
 Phe Pro Pro Arg Ser Ser Gly Cys Phe Pro Asn Met Ala Ala Lys Val
      50                  55                  60                
 Asn Gly Asn Pro His Ser Thr Pro Val Ser Gly Pro Pro Ala Phe Leu
  65                  70                  75                  80
 Thr Gln Gly Trp Gly Ser Thr Tyr Gln Ala Trp Gln Gln Pro Thr Gln
                  85                  90                  95    
 Gln Val Pro Ser His Ala Ala Ser Ala Ala Pro Gln Ala Ser Ser Pro
             100                 105                 110        
 Pro Asp Tyr Thr Met Ala Trp Ala Glu Tyr Tyr Arg Gln Gln Val Ala
         115                 120                 125            
 Phe Tyr Gly Gln Thr Leu Gly Gln Ala Gln Ala
     130                 135                



      <210> 774
      <211> 86
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(86)
      <223> Xaa = any amino acid or nothing 


      <400> 774
 Ser Leu Gly Ser Pro Val Leu Pro Gly Ser Gly Ala Ala Gly Val Ser
   1               5                  10                  15    
 Thr Val Ala His Ser Ser Ala His Xaa Val Glu Ala Asn Trp Asp Ser
              20                  25                  30        
 Cys Gln Gly Gly Gly Leu Gly Ser Ala Arg Ala Ala Arg Arg Ala Pro
          35                  40                  45            
 Ala Val His Trp Gln Gln Leu His Ser Gly Asp Trp Val Pro Gln Ile
      50                  55                  60                
 Arg Thr Arg Ala Leu Val His His His Phe Arg Arg Pro Leu Leu Arg
  65                  70                  75                  80
 Pro Ala His Ser Gln Gln
                  85    



      <210> 775
      <211> 99
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(99)
      <223> Xaa = any amino acid or nothing 


      <400> 775
 Ile Met Gly Asp Ala Lys Asn Phe Leu Tyr Ala Trp Cys Gly Lys Arg
   1               5                  10                  15    
 Lys Met Thr Pro Ser Tyr Glu Ile Arg Ala Val Gly Ser Pro Asn Gly
              20                  25                  30        
 His Arg Phe Met Pro Glu Gly Asp Val His Gly Leu Gly Lys Cys Gly
          35                  40                  45            
 Met Gly Asn Ser Thr Asn Lys Lys Asp Ala Leu Ser Asn Ala Ala Arg
      50                  55                  60                
 Asp Phe Val Asn Tyr Ser Gly Arg Ile Asn Glu Ile Tyr Met Xaa Glu
  65                  70                  75                  80
 Gln Gly Ser Ala Ile Gly Glu Leu Ser His Met Tyr Ile Ser Phe Ile
                  85                  90                  95    
 Arg Pro Glu
            



      <210> 776
      <211> 159
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(159)
      <223> Xaa = any amino acid or nothing 


      <400> 776
 Asn Phe Gln Ala Gln Thr Gly Arg Arg Ala Leu Leu Arg Cys Phe Gln
   1               5                  10                  15    
 Thr Phe Tyr Ile Ser Ile Val Asp Leu Cys Glu Asn Gly Gly Lys Arg
              20                  25                  30        
 Pro Thr Thr Asn Ser Ser Ala Ser Phe Thr Lys Glu Gln Ala Asp Ala
          35                  40                  45            
 Ile Arg Arg Ile Arg Asn Ser Lys Asp Ser Trp Asp Met Leu Gly Val
      50                  55                  60                
 Lys Pro Gly Ala Ser Arg Asp Glu Val Asn Lys Ala Tyr Arg Lys Leu
  65                  70                  75                  80
 Ala Val Leu Leu His Pro Asp Lys Cys Val Ala Pro Gly Ser Glu Asp
                  85                  90                  95    
 Ala Phe Lys Ala Val Val Asn Ala Arg Thr Ala Leu Leu Lys Asn Ile
             100                 105                 110        
 Lys Xaa Lys Val Gln Lys Lys Ala Thr Cys Gly Thr Gln Met Gln Thr
         115                 120                 125            
 Asp Phe Pro Xaa Arg Xaa Asn Asn Gln Arg Gly Gly Phe Leu Pro Lys
     130                 135                 140                
 Asn Leu Thr Ala Leu Phe Ile His Val Leu Ala Phe Val Tyr Gln
 145                 150                 155                



      <210> 777
      <211> 222
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(222)
      <223> Xaa = any amino acid or nothing 


      <400> 777
 Thr Val Cys Gln His Thr Gln Tyr Lys Glu Ser Arg Glu Ser Gly Ala
   1               5                  10                  15    
 Phe Cys Arg Arg Ala Trp Gly Leu Ser Gly Gly Asp Lys Gly Lys Gln
              20                  25                  30        
 Lys Pro Met Ser Arg Ser Pro Gly Leu Ser Pro Gln Ala Ser Pro Gln
          35                  40                  45            
 Lys Ser Leu Leu Trp Gly Glu Gln Pro Cys Ile Gly His Arg Cys Thr
      50                  55                  60                
 Lys Leu Thr Val Asn Pro Lys Pro Pro Gln Thr Ser Gln Ala Ala Cys
  65                  70                  75                  80
 Pro His Pro Glu Pro Ser Gly Leu Pro Cys Met Glu Ser His Ser Gln
                  85                  90                  95    
 Lys Ser Leu Phe Pro Glu Ser Ala Ile Val Ala Arg Gly His Val Phe
             100                 105                 110        
 Gln Gln Arg Leu Gly Ser Gly Pro Leu Cys Pro Leu Pro Thr Leu Ser
         115                 120                 125            
 Pro Lys Ser Arg Pro Pro Leu Thr Ser Leu Ala Leu His Leu Gly Val
     130                 135                 140                
 Pro Pro Ser Pro Arg Tyr Gly Pro Arg Xaa Glu Gly Leu Gly Met Gly
 145                 150                 155                 160
 Glu Ala Gln Asn Ala Gly Glu Met Arg Pro Gly Glu Pro Trp Gly Lys
                 165                 170                 175    
 Pro Ser Gln Gly Pro Pro Thr Glu Leu Ala Leu Gly Phe Val Ser Pro
             180                 185                 190        
 Thr Pro Phe Pro Ser Pro Leu Pro Pro Thr His Ser Gly Gly Pro His
         195                 200                 205            
 Gln Asp Ser Trp Ala Gln Cys Gly Ser Pro Thr Cys Leu Phe
     210                 215                 220        



      <210> 778
      <211> 77
      <212> PRT
      <213> Homo sapiens


      <400> 778
 Leu Leu Leu Tyr Cys Gly Thr Asn Leu Gly Ile Pro Asn Ser Gln Glu
   1               5                  10                  15    
 Tyr Phe Leu Leu Phe Gly Arg Gln Val Gly Leu Gln Glu Gln Thr Asp
              20                  25                  30        
 Leu Leu His Phe Leu Gln Arg Gln Gln Arg Val Ala Asp Arg Val Leu
          35                  40                  45            
 Lys Gln His Val Gln Gln His His Gly Ala Ile Cys Arg Val Arg Gly
      50                  55                  60                
 Arg Val Gly Arg Pro Gly Val Pro Ala Gln Gly Pro Gln
  65                  70                  75        



      <210> 779
      <211> 46
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(46)
      <223> Xaa = any amino acid or nothing 


      <400> 779
 Leu Gly Pro Leu Pro Gln Gly Thr Phe Ser Pro Glu Gly Trp Arg Gln
   1               5                  10                  15    
 Pro Xaa Pro Cys Gly Trp Pro Pro Cys Arg Ala Phe Met Glu Ser Ser
              20                  25                  30        
 Ser Leu Gln Lys Arg Met Arg Ser Val Leu Asp Pro Leu Glu
          35                  40                  45    



      <210> 780
      <211> 46
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(46)
      <223> Xaa = any amino acid or nothing 


      <400> 780
 Leu Gly Pro Leu Pro Gln Gly Thr Phe Ser Pro Glu Gly Trp Arg Gln
   1               5                  10                  15    
 Pro Xaa Pro Cys Gly Trp Pro Pro Cys Arg Ala Phe Met Glu Ser Ser
              20                  25                  30        
 Ser Leu Gln Lys Arg Met Arg Ser Val Leu Asp Pro Leu Glu
          35                  40                  45    



      <210> 781
      <211> 44
      <212> PRT
      <213> Homo sapiens


      <400> 781
 Ser Ser Gly Arg Gly Gly Gly Pro Leu Gly Ser Leu Ser Ser Gly Trp
   1               5                  10                  15    
 Arg Cys Phe Trp Arg Leu Gly Ala Gly His Ser Val Ala Pro Leu Thr
              20                  25                  30        
 Arg Leu Pro Tyr Arg Glu Gly Asn Leu Phe Ala Lys
          35                  40                



      <210> 782
      <211> 44
      <212> PRT
      <213> Homo sapiens


      <400> 782
 Ser Ser Gly Arg Gly Gly Gly Pro Leu Gly Ser Leu Ser Ser Gly Trp
   1               5                  10                  15    
 Arg Cys Phe Trp Arg Leu Gly Ala Gly His Ser Val Ala Pro Leu Thr
              20                  25                  30        
 Arg Leu Pro Tyr Arg Glu Gly Asn Leu Phe Ala Lys
          35                  40                



      <210> 783
      <211> 106
      <212> PRT
      <213> Homo sapiens


      <400> 783
 Met Glu Arg Phe Leu Met Asp Gly Phe Gln Pro Gln Gln Leu Ser Thr
   1               5                  10                  15    
 Tyr Ala Leu Thr Leu Tyr Lys His Thr Ala Thr Val Asp Gly Lys Thr
              20                  25                  30        
 Ile Leu Val Ala Asp Ile Asn Val Thr Gln Lys Ser Phe Asn Phe Ala
          35                  40                  45            
 Lys Lys Phe Ser Leu Pro Leu Tyr Phe Val Ser Ala Ala Asp Gly Thr
      50                  55                  60                
 Asn Val Val Lys Leu Phe Asn Asp Ala Ile Arg Leu Ala Val Ser Tyr
  65                  70                  75                  80
 Lys Gln Asn Ser Gln Asp Phe Met Asp Glu Ile Phe Gln Glu Leu Glu
                  85                  90                  95    
 Asn Phe Ser Leu Glu Gln Glu Glu Glu Asn
             100                 105    



      <210> 784
      <211> 106
      <212> PRT
      <213> Homo sapiens


      <400> 784
 Met Glu Arg Phe Leu Met Asp Gly Phe Gln Pro Gln Gln Leu Ser Thr
   1               5                  10                  15    
 Tyr Ala Leu Thr Leu Tyr Lys His Thr Ala Thr Val Asp Gly Lys Thr
              20                  25                  30        
 Ile Leu Val Ala Asp Ile Asn Val Thr Gln Lys Ser Phe Asn Phe Ala
          35                  40                  45            
 Lys Lys Phe Ser Leu Pro Leu Tyr Phe Val Ser Ala Ala Asp Gly Thr
      50                  55                  60                
 Asn Val Val Lys Leu Phe Asn Asp Ala Ile Arg Leu Ala Val Ser Tyr
  65                  70                  75                  80
 Lys Gln Asn Ser Gln Asp Phe Met Asp Glu Ile Phe Gln Glu Leu Glu
                  85                  90                  95    
 Asn Phe Ser Leu Glu Gln Glu Glu Glu Asn
             100                 105    



      <210> 785
      <211> 106
      <212> PRT
      <213> Homo sapiens


      <400> 785
 Met Glu Arg Phe Leu Met Asp Gly Phe Gln Pro Gln Gln Leu Ser Thr
   1               5                  10                  15    
 Tyr Ala Leu Thr Leu Tyr Lys His Thr Ala Thr Val Asp Gly Lys Thr
              20                  25                  30        
 Ile Leu Val Ala Asp Ile Asn Val Thr Gln Lys Ser Phe Asn Phe Ala
          35                  40                  45            
 Lys Lys Phe Ser Leu Pro Leu Tyr Phe Val Ser Ala Ala Asp Gly Thr
      50                  55                  60                
 Asn Val Val Lys Leu Phe Asn Asp Ala Ile Arg Leu Ala Val Ser Tyr
  65                  70                  75                  80
 Lys Gln Asn Ser Gln Asp Phe Met Asp Glu Ile Phe Gln Glu Leu Glu
                  85                  90                  95    
 Asn Phe Ser Leu Glu Gln Glu Glu Glu Asn
             100                 105    



      <210> 786
      <211> 129
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(129)
      <223> Xaa = any amino acid or nothing 


      <400> 786
 Met Leu Arg Tyr Val Glu Thr Leu Leu Thr His Met Gly Val Asn Pro
   1               5                  10                  15    
 Leu Glu Ala Glu Glu Leu Ile Arg Asp Glu Asp Ser Pro Asp Phe Glu
              20                  25                  30        
 Phe Ile Val Tyr Asp Ser Trp Lys Ile Thr Gly Arg Thr Ala Glu Asn
          35                  40                  45            
 Thr Phe Asn Lys Thr His Thr Phe His Phe Leu Leu Gly Ser Ile Tyr
      50                  55                  60                
 Gly Glu Cys Pro Val Pro Lys Pro Arg Val Asp Arg Pro Arg Lys Val
  65                  70                  75                  80
 Pro Val Ile Gln Glu Glu Arg Ala Met Pro Ala His Leu Ile Pro Pro
                  85                  90                  95    
 Met Ser Phe Phe Asp Phe Val Gly Asp Pro His Ser Phe Pro Arg Thr
             100                 105                 110        
 Val Glu Asn Ile Phe His Val Ser Phe Ile Ile Arg Asp Gly Xaa Ala
         115                 120                 125            
 Glu
    



      <210> 787
      <211> 97
      <212> PRT
      <213> Homo sapiens


      <400> 787
 Asn Leu Val Tyr Ile Ser Lys Val Arg Ile Lys Lys Leu Pro Cys Phe
   1               5                  10                  15    
 Phe Arg Trp Phe Met Lys Tyr Gln His Val Asp Pro Glu Glu Ala Val
              20                  25                  30        
 Arg Ile His Thr Asp Val Gln Thr Lys Lys Ser Met Ala Ile His Trp
          35                  40                  45            
 Gly Thr Phe Ala Leu Ala Asn Glu His Tyr Leu Glu Pro Pro Val Lys
      50                  55                  60                
 Leu Asn Glu Ala Leu Glu Arg Tyr Gly Leu Asn Ala Glu Asp Phe Phe
  65                  70                  75                  80
 Val Leu Lys His Gly Glu Ser Arg Tyr Leu Asn Asn Asn Asp Glu Asn
                  85                  90                  95    
 Phe
    



      <210> 788
      <211> 671
      <212> PRT
      <213> Homo sapiens


      <400> 788
 Met Ala Trp Arg Arg Leu Ser Arg Arg Arg Val Ala Gly Asn Asp Arg
   1               5                  10                  15    
 Thr Trp Pro Ala Pro Gln Arg His Trp Arg Tyr Thr Thr Leu Phe Glu
              20                  25                  30        
 Met Lys Arg Ser Lys Glu Leu Pro Val Arg Trp Cys Asp Phe Ser Ala
          35                  40                  45            
 Phe Thr Pro Met Met Arg Thr His Glu Gly Asn Arg Pro Gly Asp Asn
      50                  55                  60                
 Trp Gln Phe Asp Gly Asp Ala Glu Thr Ile Ala His Phe Ala Arg Met
  65                  70                  75                  80
 Thr Thr Val Phe Thr Thr Leu Lys Pro Tyr Leu Lys Glu Ala Val Ala
                  85                  90                  95    
 Leu Asn Ala Lys Ser Gly Leu Pro Gln Leu Val Asp Ile Arg Glu Glu
             100                 105                 110        
 Met Pro Glu Gln Thr Ala Lys Arg Met Leu Ser Leu Leu Gly Ile Leu
         115                 120                 125            
 Lys Tyr Lys Pro Ser Gly Asn Ala Thr Asp Met Gly Lys Glu His Arg
     130                 135                 140                
 Thr Leu Pro Ala Asn Phe Ala Phe Asn Glu Phe Val Ala Arg His Leu
 145                 150                 155                 160
 Arg His Arg Arg Thr Val Asn Gln Leu Gln Pro Gly Glu Asn His Leu
                 165                 170                 175    
 Gly Gly Gly Val Ala Val Ala Ser Ser Phe Gly Thr Ser Ile Ile Ala
             180                 185                 190        
 Thr Pro Ile Ala Val Thr Pro Pro Ile Asn Leu Pro Thr Ile Ile Gly
         195                 200                 205            
 Lys Ile Met Ala Phe Met Leu Ala Ala Ala Lys Pro Lys Trp Ser Pro
     210                 215                 220                
 Arg Ala Lys Ala Ala Glu Thr Ala Lys Ala Gln Leu Met Thr Leu Pro
 225                 230                 235                 240
 Arg Asn Ser Val Ile Leu Phe Ala Ser Arg Leu Ser Ser His Ala Pro
                 245                 250                 255    
 Ala Gly Leu Gln Gly His Ile Asn Phe Thr Ile Ser Thr Lys Ile Leu
             260                 265                 270        
 Asp Ser Asn Glu Pro Cys Gly Gly Gln Lys Gly Phe Val Pro Gln Lys
         275                 280                 285            
 Gly Arg Ser Asp Thr Leu Ile Lys Pro Val Leu Val Lys Asp Pro Met
     290                 295                 300                
 Val Ser Gln Gly Leu Arg Cys Leu Lys Asn Ser Ala Thr Ser Thr Thr
 305                 310                 315                 320
 Asn Leu Tyr Thr Gln Ala Leu Leu Ala Tyr Ile Phe Ser Leu Ala Gly
                 325                 330                 335    
 Glu Met Asp Ile Arg Asn Ile Leu Leu Lys Gln Leu Asp Gln Gln Ala
             340                 345                 350        
 Ile Ile Ser Gly Phe Ile Leu Val Thr Val Ile Lys Ser Ser Asn Ala
         355                 360                 365            
 Asp Asp Thr Ser Ile Tyr Met Phe Tyr Gln Lys Val Gly Asp Asn Ser
     370                 375                 380                
 Ile Asp Ser Trp Lys Asn Ala Gly Arg Val Phe Lys Asp Ser Asp Lys
 385                 390                 395                 400
 Phe Asp Ala Asn Asp Pro Ile Leu Lys Asp Gln Thr Gln Glu Trp Ser
                 405                 410                 415    
 Gly Cys Asp Pro Gln Leu Gly Cys Asp Phe Val Val Ser Glu Ala Arg
             420                 425                 430        
 Ala Phe Ala Ser Asp His Arg Gln Ala Glu Trp Ser Ser Lys Asp Asp
         435                 440                 445            
 Phe Met Arg Leu Gly Lys Pro Ile Leu Phe Phe Gly Val Thr Ala Gly
     450                 455                 460                
 Asn Met Asp Ser Met Ile Asn Arg Tyr Thr Ala Asp Arg Arg Leu Arg
 465                 470                 475                 480
 His Asp Asp Ala Tyr Thr Pro Asp Asn Val Ala Gly Lys Arg Pro Asp
                 485                 490                 495    
 Arg Ala Thr Leu Val Tyr Thr Gln Arg Cys Lys Glu Ala Trp Lys Asp
             500                 505                 510        
 Val Pro Val Ile Leu Gly Gly Val Gly Met Met Cys Ser Leu Ser Glu
         515                 520                 525            
 Gln Gly Lys Gln Leu Ala Ile Gln Val Ser Asn Ile Leu Gly Met Asp
     530                 535                 540                
 Val Cys Gly Ile Asp Leu Leu Met Lys Asp Asp Gly Ser Phe Cys Val
 545                 550                 555                 560
 Cys Glu Ala Asn Ala Asn Val Gly Tyr Pro Ala Leu Gly Ser Thr Met
                 565                 570                 575    
 Gly Cys Ser Asn Ser Gly Met Val Thr Thr Pro Ile Lys Trp Leu Ser
             580                 585                 590        
 Met Ile Ser Val Gln Cys Leu Ala Asn Gly Thr Phe Leu Ser Pro Ser
         595                 600                 605            
 Leu Thr Lys Cys Pro Lys Gly Ile Arg Ala Ser Val Pro Leu Ser Gly
     610                 615                 620                
 Gly Pro Arg Ser Leu Lys Ala Arg Thr Phe Ser Ala Phe Ser Gly Gln
 625                 630                 635                 640
 Pro Ser Ser Gln Pro Ser Ser Gln Pro Thr Asn Tyr Pro Ser Thr Ile
                 645                 650                 655    
 Cys Gly His Asn Ser Gly Ile Gln Pro Lys Phe Gln Leu Asn Gly
             660                 665                 670    



      <210> 789
      <211> 98
      <212> PRT
      <213> Homo sapiens


      <400> 789
 His Ala Ser Val Leu Pro Pro Arg Ser Cys Arg Val Phe Trp Ile His
   1               5                  10                  15    
 Ser Gly Thr Thr Met Ser Lys Val Ser Phe Lys Ile Thr Leu Thr Ala
              20                  25                  30        
 Asp Pro Arg Leu Pro Tyr Lys Val Leu Ser Val Ala Glu Ser Thr Pro
          35                  40                  45            
 Phe Thr Ala Val Leu Asn Ala Cys Met Gln Asn Thr Val Gln Ser Leu
      50                  55                  60                
 Leu Gly Arg Cys Asn His Tyr Gln Pro Gly Asn Thr Asp Leu Ala Leu
  65                  70                  75                  80
 Arg Ile Leu Glu Ser Leu Pro Leu Ser Phe Trp Pro Thr Glu Asn Glu
                  85                  90                  95    
 Val Ile
        



      <210> 790
      <211> 310
      <212> PRT
      <213> Homo sapiens


      <400> 790
 Arg Thr Arg Gly Arg Glu Thr Lys Pro His Thr Lys Glu Arg Gly Met
   1               5                  10                  15    
 Met Ala Lys Lys Pro Pro Lys Pro Gly Pro Arg Arg Ile Phe Gln Glu
              20                  25                  30        
 Arg Leu Lys Ile Thr Ala Leu Pro Leu Tyr Phe Glu Gly Phe Leu Leu
          35                  40                  45            
 Ile Lys Arg Ser Gly Tyr Arg Glu Tyr Glu His Tyr Trp Thr Glu Leu
      50                  55                  60                
 Arg Gly Thr Thr Leu Phe Phe Tyr Thr Asp Lys Lys Ser Ile Ile Tyr
  65                  70                  75                  80
 Val Asp Lys Leu Asp Ile Val Asp Leu Thr Cys Leu Thr Glu Gln Asn
                  85                  90                  95    
 Ser Thr Glu Lys Asn Cys Ala Lys Phe Thr Leu Val Leu Pro Lys Glu
             100                 105                 110        
 Glu Val Gln Leu Lys Thr Glu Asn Thr Glu Ser Gly Glu Glu Trp Arg
         115                 120                 125            
 Gly Phe Ile Leu Thr Val Thr Glu Leu Ser Val Pro Gln Asn Val Ser
     130                 135                 140                
 Leu Leu Pro Gly Gln Val Ile Lys Leu His Glu Val Leu Glu Arg Glu
 145                 150                 155                 160
 Lys Lys Arg Arg Ile Glu Thr Glu Gln Ser Thr Ser Val Glu Lys Glu
                 165                 170                 175    
 Lys Glu Pro Thr Glu Asp Tyr Val Asp Val Leu Asn Pro Met Pro Ala
             180                 185                 190        
 Cys Phe Tyr Thr Val Ser Arg Lys Glu Ala Thr Glu Met Leu Gln Lys
         195                 200                 205            
 Asn Pro Ser Leu Gly Asn Met Ile Leu Arg Pro Gly Ser Asp Ser Arg
     210                 215                 220                
 Asn Tyr Ser Ile Thr Ile Arg Gln Glu Ile Asp Ile Pro Arg Ile Lys
 225                 230                 235                 240
 His Tyr Lys Val Met Ser Val Gly Gln Asn Tyr Thr Ile Glu Leu Glu
                 245                 250                 255    
 Lys Pro Val Thr Leu Pro Asn Leu Phe Ser Val Ile Asp Tyr Phe Val
             260                 265                 270        
 Lys Glu Thr Arg Gly Asn Leu Arg Pro Phe Ile Cys Ser Thr Asp Glu
         275                 280                 285            
 Asn Thr Gly Gln Glu Pro Ser Met Glu Gly Arg Ser Glu Lys Leu Lys
     290                 295                 300                
 Lys Asn Pro His Ile Ala
 305                 310



      <210> 791
      <211> 58
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(58)
      <223> Xaa = any amino acid or nothing 


      <400> 791
 Arg Trp Val Leu Leu Phe Phe Leu Ser Phe Val Asn Ala Val Met Leu
   1               5                  10                  15    
 Cys Ala Gln Val Gly Ser His His Pro Ala Leu Pro Trp Ala Ser Pro
              20                  25                  30        
 Pro Glu Cys Cys Arg Asp His Ile Cys Pro His Pro Val Gly Pro Pro
          35                  40                  45            
 Gly Pro Pro Pro Xaa Pro Phe Gln Pro Gly
      50                  55            



      <210> 792
      <211> 71
      <212> PRT
      <213> Homo sapiens


      <400> 792
 Gly Arg Met Ala Gln Asp Leu Ser Glu Lys Asp Leu Leu Lys Met Glu
   1               5                  10                  15    
 Val Glu Gln Leu Lys Lys Glu Val Lys Asn Thr Arg Ile Pro Ile Ser
              20                  25                  30        
 Lys Ala Gly Lys Glu Ile Lys Glu Tyr Val Glu Ala Gln Ala Gly Asn
          35                  40                  45            
 Asp Pro Phe Leu Lys Gly Ile Pro Glu Asp Lys Asn Pro Phe Lys Glu
      50                  55                  60                
 Lys Gly Gly Cys Leu Ile Ser
  65                  70    



      <210> 793
      <211> 1026
      <212> PRT
      <213> Homo sapiens


      <400> 793
 Ala Ser Gln Ala Phe Leu Arg Val Pro Ala Leu Pro Met Asp Val Leu
   1               5                  10                  15    
 Pro Leu Leu Val Val Glu Asp Pro Pro Thr Gly Ala Ala Arg Gly Pro
              20                  25                  30        
 Gly Pro Asp Pro Thr Thr His Gln Pro Pro Glu Val Ala Ile Phe Ala
          35                  40                  45            
 Ala Ser Arg Val Glu Gly Gly Leu Arg Pro Glu Gln Glu Asn Arg Arg
      50                  55                  60                
 Asp Ala Gly Arg Pro Gln Ile Arg Thr Pro Lys Gln Gly Arg Ala Glu
  65                  70                  75                  80
 Gln Thr Arg His Pro Ala Arg Val Ser Ser Gly Gly Gly Gly Ser Gln
                  85                  90                  95    
 Glu Pro Thr Gln Val Asn Thr Phe Met Ser Phe Ile Phe Pro Met Val
             100                 105                 110        
 Val Ile Ser Val Leu Asn Thr Ile Ile Ala Asn Lys Leu Thr Val Met
         115                 120                 125            
 Val Arg Gln Ala Ala Glu Gln Gly Gln Val Cys Thr Val Gly Gly Glu
     130                 135                 140                
 His Ser Thr Phe Ser Met Ala Ile Glu Pro Gly Arg Val Gln Ala Leu
 145                 150                 155                 160
 Arg His Gly Val Arg Val Leu Arg Ala Val Val Ile Ala Phe Val Val
                 165                 170                 175    
 Cys Trp Leu Pro Tyr His Val Arg Arg Leu Met Phe Cys Tyr Ile Ser
             180                 185                 190        
 Asp Glu Gln Trp Thr Pro Phe Leu Tyr Asp Phe Tyr His Tyr Phe Tyr
         195                 200                 205            
 Met Val Thr Asn Ala Leu Phe Tyr Val Ser Ser Thr Ile Asn Pro Ile
     210                 215                 220                
 Leu Tyr Asn Leu Val Ser Ala Asn Phe Arg His Ile Phe Leu Ala Thr
 225                 230                 235                 240
 Leu Ala Cys Leu Cys Pro Ala Lys Ala Gln Gly Leu Cys Gln Asp Thr
                 245                 250                 255    
 Thr Trp Glu Gly Ala Gln Ala Ser Ala Ser Arg Ser Ser Ala Val Ala
             260                 265                 270        
 Ser Arg Ala Arg Gln Lys Gly Arg Arg Ile Arg Gly Leu Val Ser Ser
         275                 280                 285            
 Thr Cys Pro Ser Gly Arg Gly Gln Asp Gly Asp Pro Gly Ser Thr Glu
     290                 295                 300                
 His Met Thr Ser Gln Ala Pro Gly Leu Arg Arg Ser Pro Lys Pro Lys
 305                 310                 315                 320
 Arg Arg Gln Ser Gln Glu Lys Leu Ala Gly Thr Ser Gln Glu Leu Gly
                 325                 330                 335    
 Ala Thr Gly Ser Lys Ser Arg Asp Thr Cys Pro Arg Thr Thr Asp Thr
             340                 345                 350        
 Pro Thr Thr Pro Asp Leu Val Ser Leu Ala Cys Gly Gln Val Met Met
         355                 360                 365            
 Trp Pro Arg Lys Leu Ala Leu Arg Ala Met Ser Ala Ser Val Met Glu
     370                 375                 380                
 Ser Gly Ala Pro Glu Pro Ala Pro Gly Asp Gly Thr Ala Leu Thr Ala
 385                 390                 395                 400
 Gln Thr Pro Thr Pro Thr Pro Thr Ile Cys Arg Pro Val Ser Leu Leu
                 405                 410                 415    
 Ala Gln Ser Gly Thr Arg Ala Leu Asp Cys Cys Pro Pro Arg Ala Pro
             420                 425                 430        
 Cys Leu Asn Leu Ser Thr Pro Arg Phe Val Pro Arg Val Gly His Ser
         435                 440                 445            
 Val Met Phe Lys Gly Ser Leu Gly Ser Val Pro Arg Arg Lys Glu Leu
     450                 455                 460                
 Glu Gln Arg Gly Asn Lys Ala Asp Gly Arg Ala His Val Arg Thr Thr
 465                 470                 475                 480
 Arg Glu Pro Val Pro Asp Gln Phe Pro Arg Pro Gln Leu Ser Pro Arg
                 485                 490                 495    
 Arg Ser Glu Gly His Arg Arg Ser Leu His Pro Asn Arg Arg Asn Thr
             500                 505                 510        
 Asp Ile Asp Asp Asn Ile Ile Gly Met Glu Ile Gln Pro Trp Asn Ser
         515                 520                 525            
 Ser Ser Val Met Glu Arg Glu Ile Trp Gly His Trp Pro Gly Ser Leu
     530                 535                 540                
 Pro Gln Ala Pro Leu Asn Ser Ser Pro Leu Lys Pro Glu Pro Gly Pro
 545                 550                 555                 560
 Thr Asn Gln Val Thr Ser Arg Ala Thr Gly Asp Thr Pro Ser Gln Ala
                 565                 570                 575    
 Gln Thr Pro Ala Asn Tyr Pro Gly Pro Gly Ala Arg Pro Cys Gln Leu
             580                 585                 590        
 Asn Pro His His Leu Thr Trp Phe Lys Ala His Gly His Arg Glu Pro
         595                 600                 605            
 Val Cys Ser Trp Ala Lys Gly Gln Thr Gly Pro Gly Glu Val Asp Val
     610                 615                 620                
 Ser Cys Thr Tyr Thr Ser Ser Arg Gln Glu Asp Ala Arg Arg Thr Asp
 625                 630                 635                 640
 Gly Glu Thr Gly Trp Glu Arg Glu Cys Asp Leu Pro Val Ile Pro Glu
                 645                 650                 655    
 Val Trp Leu Pro Glu Leu Glu Leu Lys Pro Glu Pro Phe Thr Lys Ser
             660                 665                 670        
 Ser Ser Gln Asp Leu Ser Trp Pro Trp Met Asn Pro Val Arg Cys Leu
         675                 680                 685            
 Ser Cys Leu Tyr Arg Gly Ile Arg Ala Leu Pro Ala Ser His Tyr Trp
     690                 695                 700                
 Thr Leu Val Lys Glu Leu Gly Asp Arg Val Ala Ala Glu Gly Thr Glu
 705                 710                 715                 720
 Pro Ala Val Ser Arg Val Gln Arg Arg Thr Thr Arg Gln Ser Ala Lys
                 725                 730                 735    
 Gly Ser Val Arg Arg Ser Ser Met Gly Arg Ala Pro Cys His Phe Gln
             740                 745                 750        
 Gln Gly Ala His Arg Glu Gly Glu Pro Pro Val Lys His Pro Ser Pro
         755                 760                 765            
 Lys Ser Pro Ala Gly Ile Gly Cys Ser Ser Leu Cys Val Glu Thr Ser
     770                 775                 780                
 His Ser Gly Val Phe Phe Thr Gln Gly Leu His Leu Gly Val His Trp
 785                 790                 795                 800
 Gly Gly Leu Ser Leu Ser Arg Val Leu His Pro Thr His Leu Ser Leu
                 805                 810                 815    
 Gly Ser His Gly Glu Gln Glu His Arg Gly Gln Gln Ala Glu Gly Ser
             820                 825                 830        
 Ala Arg Ala Lys Gly Thr Phe Ala Leu Ala Ser Cys Ser Pro Gly Thr
         835                 840                 845            
 Arg Ser Arg Thr Ser Ala Asp Pro Lys Gly Val His Ser Gly Tyr Gly
     850                 855                 860                
 Pro Ser Gly Val Pro Leu Lys Ala Gly Arg Gly Gln Asp Phe Ile Leu
 865                 870                 875                 880
 Phe Leu Pro Pro Leu Arg Ala Val Thr Asn Cys Ser Pro Asp Glu Val
                 885                 890                 895    
 Asn Ser Met Ser Asp Gly Val Val Pro Ser Leu Pro Asp Gly Val Val
             900                 905                 910        
 Pro Ser Leu Ser Asp Gly Met Val Pro Gly Leu Ser Asp Gly Val Val
         915                 920                 925            
 Pro Ser Leu Ser Asp Gly Val Val Pro Gly Leu Ser Asp Gly Val Val
     930                 935                 940                
 Pro Gly Leu Ser Asp Gly Met Val Pro Gly Leu Ser Asp Gly Val Val
 945                 950                 955                 960
 Pro Ser Leu Ser Asp Gly Val Val Pro Gly Leu Ser Asp Gly Leu Val
                 965                 970                 975    
 Pro Gly Leu Phe Asp Gly Val Val Pro Ser Leu Ser Glu Gly Val Val
             980                 985                 990        
 Pro Ser Leu Ser Asp Gly Val Val Pro Gly Leu Ser Asp Gly Leu Val
         995                1000                1005            
 Pro Gly Leu Phe Asp Gly Val Val Pro Ser Leu Ser Glu Asp Gly Glu
    1010                1015                1020                
 Arg Ser
1025    



      <210> 794
      <211> 82
      <212> PRT
      <213> Homo sapiens


      <400> 794
 Met Pro Lys Lys Ala Gly Ala Thr Thr Lys Gly Lys Ser Gln Ser Lys
   1               5                  10                  15    
 Glu Pro Glu Arg Pro Leu Pro Pro Leu Gly Pro Val Ala Val Asp Pro
              20                  25                  30        
 Lys Gly Cys Val Thr Ile Ala Ile His Ala Lys Pro Gly Ser Lys Gln
          35                  40                  45            
 Asn Ala Val Thr Asp Leu Thr Ala Glu Ala Val Asn Val Ala Ile Ala
      50                  55                  60                
 Ala Pro Pro Ser Glu Gly Glu Ala Asn Ala Glu Leu Cys Arg Tyr Leu
  65                  70                  75                  80
 Ser Lys
        



      <210> 795
      <211> 55
      <212> PRT
      <213> Homo sapiens


      <400> 795
 Thr Lys Glu Gln Met Ser Gly Pro Leu Phe Pro Val Cys Ser Cys Pro
   1               5                  10                  15    
 Gln Leu Pro Phe Met Leu Ser Pro Cys His Met His His His Pro Gly
              20                  25                  30        
 His Val Ala Leu Ser Gln Thr Val Ser Pro Ala Ser Leu Leu Thr Gln
          35                  40                  45            
 Gly Leu Gly Leu Pro Gln His
      50                  55



      <210> 796
      <211> 36
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(36)
      <223> Xaa = any amino acid or nothing 


      <400> 796
 Gly Gly Gly Val Gly Gly Gly Gly Gly Gly His Leu Gly Xaa Asp Ser
   1               5                  10                  15    
 Lys Gly Arg Xaa Gly Trp Gly Pro Trp Leu Ala Gly Gly Asp Cys Ile
              20                  25                  30        
 Lys Glu Asn Thr
          35    



      <210> 797
      <211> 421
      <212> PRT
      <213> Homo sapiens


      <400> 797
 Met Thr Arg Gln Cys Gln Ala Ser Asn Gln Gln Leu Gly Pro Gln Pro
   1               5                  10                  15    
 Leu Ala Thr Thr Pro Pro Asp Leu Phe Leu Gly Phe Gln Gln Leu Phe
              20                  25                  30        
 Gly Thr Phe Ala Ser Trp Gly Arg Glu Pro His Cys Gly Gly Pro Asp
          35                  40                  45            
 Phe Pro Gln Pro Ile Gln Thr Val Glu Asp Ala Leu Arg Lys Pro Ser
      50                  55                  60                
 Gly Leu Gln Leu Ile Asn Tyr Ile His Thr Tyr Leu Pro Leu Pro Ala
  65                  70                  75                  80
 Lys Val Leu Asp Phe Pro Pro Lys Pro Pro Gln Pro Gly Met Asp Val
                  85                  90                  95    
 Gln Gly Phe Val Leu Tyr Leu Met Ser Pro Pro Ala Ser Gln Gly His
             100                 105                 110        
 Pro Val Pro Lys Tyr Gln Ile His Arg Thr Phe Arg Pro Ala Pro Pro
         115                 120                 125            
 Gly Gly Val Ala Gly Val Leu Val Gly His Pro Phe Asp Thr Val Lys
     130                 135                 140                
 Val Arg Leu Gln Val Gln Ser Val Glu Lys Pro Gln Tyr Arg Gly Thr
 145                 150                 155                 160
 Leu His Cys Phe Lys Ser Ile Ile Lys Gln Glu Ser Val Leu Gly Leu
                 165                 170                 175    
 Tyr Lys Gly Leu Gly Ser Pro Leu Met Gly Leu Thr Phe Ile Asn Ala
             180                 185                 190        
 Leu Val Phe Gly Val Gln Gly Asn Thr Leu Arg Ala Leu Gly His Asp
         195                 200                 205            
 Ser Pro Leu Asn Gln Phe Leu Ala Gly Ala Ala Ala Gly Ala Ile Gln
     210                 215                 220                
 Cys Val Ile Cys Cys Pro Met Glu Leu Ala Lys Thr Arg Leu Gln Leu
 225                 230                 235                 240
 Gln Asp Ala Gly Pro Ala Arg Thr Tyr Lys Gly Ser Leu Asp Cys Leu
                 245                 250                 255    
 Ala Gln Ile Tyr Gly His Glu Gly Leu Arg Gly Val Asn Arg Gly Met
             260                 265                 270        
 Val Ser Thr Leu Leu Arg Glu Thr Pro Ser Phe Gly Val Tyr Phe Leu
         275                 280                 285            
 Thr Tyr Asp Ala Leu Thr Arg Ala Leu Gly Cys Glu Pro Gly Asp Arg
     290                 295                 300                
 Leu Leu Val Pro Lys Leu Leu Leu Ala Gly Gly Thr Ser Gly Ile Val
 305                 310                 315                 320
 Ser Trp Leu Ser Thr Tyr Pro Val Asp Val Val Lys Ser Arg Leu Gln
                 325                 330                 335    
 Ala Asp Gly Leu Arg Gly Ala Pro Arg Tyr Arg Gly Ile Leu Asp Cys
             340                 345                 350        
 Val His Gln Ser Tyr Arg Ala Glu Gly Trp Arg Val Phe Thr Arg Gly
         355                 360                 365            
 Leu Ala Ser Thr Leu Leu Arg Ala Phe Pro Val Asn Ala Ala Thr Phe
     370                 375                 380                
 Ala Thr Val Thr Val Val Leu Thr Tyr Ala Arg Gly Glu Glu Ala Gly
 385                 390                 395                 400
 Pro Glu Gly Glu Ala Val Pro Ala Ala Pro Ala Gly Pro Ala Leu Ala
                 405                 410                 415    
 Gln Pro Ser Ser Leu
             420    



      <210> 798
      <211> 622
      <212> PRT
      <213> Homo sapiens


      <400> 798
 Arg Arg Arg Phe Ser Ala Gly Gly Arg Ser Val Arg Arg Val Gly Glu
   1               5                  10                  15    
 Ser Cys Val Arg Asp Cys Asn Ser Gln His Thr Phe Leu Ser Asp Gln
              20                  25                  30        
 Ala Pro Ser Leu Lys Ser Ser Ala Ile Ala Leu Ala Met Leu Gln Asp
          35                  40                  45            
 Trp Cys Arg Arg Met Gly Val Asn Ala Glu Arg Ser Leu Leu Ile Leu
      50                  55                  60                
 Asp Ile Pro Asp Asp Cys Glu Glu His Glu Phe Gln Glu Ala Val Arg
  65                  70                  75                  80
 Ala Ala Leu Ser Pro Leu Gly Arg Tyr Arg Val Leu Ile Lys Val Phe
                  85                  90                  95    
 Arg Lys Glu Leu Gly Ala Arg Ala Ala Leu Val Glu Phe Ala Glu Gly
             100                 105                 110        
 Leu Asn Gln Ser Leu Ile Pro Arg Gln Ile Ala Gly Lys Gly Gly Pro
         115                 120                 125            
 Trp Lys Val Ile Ser Leu Pro Gln Ala Leu Asp Ala Glu Phe Gln Asp
     130                 135                 140                
 Ile Pro Ser Phe Pro Ala Gln Pro Gln Gly Gln Ala Val Ala Arg Gly
 145                 150                 155                 160
 Ala Gly Glu Ala Gly Ala Ala Gly Glu Ala Gly Ser Val Gly Glu Ala
                 165                 170                 175    
 Gly Gly Val Asn Glu Glu Arg Ser Ala Gly Glu Asp Glu Ala Gly Gly
             180                 185                 190        
 Ile Gly Glu Ala Gly Gly Val Gly Glu Ala Gly Ala Ala Gly Glu Ala
         195                 200                 205            
 Gly Ala Ala Gly Glu Ala Gly Ala Ala Gly Glu Ala Gly Gly Ala Gly
     210                 215                 220                
 Glu Ala Gly Gly Ala Gly Glu Ala Gly Gly Ala Gly Glu Glu Gly Gly
 225                 230                 235                 240
 Thr Gly Glu Glu Gly Gly Ala Gly Glu Ala Gly Gly Ala Gly Glu Glu
                 245                 250                 255    
 Gly Gly Glu Asp Glu Ala Gly Ala Ala Gly Glu Ala Val Gly Ala Gly
             260                 265                 270        
 Val Val Glu Ala Trp Thr Gln Ser Trp Arg Gln Thr Leu Arg Pro Leu
         275                 280                 285            
 Val Lys Thr Met Ala Tyr Arg Glu Leu Arg Pro Phe Ser Gly Arg Glu
     290                 295                 300                
 Gln Pro Gly Cys Val Glu Glu Ser Phe Glu Ser Trp Leu Glu Asp Ala
 305                 310                 315                 320
 Lys Asp Met Leu Gln Leu Trp Cys His Ala Ser Glu Arg Glu Arg Arg
                 325                 330                 335    
 Arg Arg Leu Leu Asp Ser Leu Asp Gly Leu Ala Leu Asp Ile Val Ser
             340                 345                 350        
 Gly Leu Leu Glu Glu Asp Pro Asp Phe Ser Ala Gln Asp Cys Leu Thr
         355                 360                 365            
 Ala Leu Gly Gln Val Phe Arg Ser Arg Asp Thr Trp Met Thr Ser Arg
     370                 375                 380                
 Met Lys Phe Leu Thr Cys Thr Gln Gly Pro Gln Glu Gly Leu Phe Ala
 385                 390                 395                 400
 Phe Val Val Arg Leu Glu Gly Leu Leu Gln Lys Ala Val Glu Lys Gly
                 405                 410                 415    
 Ala Val His Pro Ala Met Ala Asn His Leu Arg Leu Arg Gln Val Leu
             420                 425                 430        
 Ser Arg Ala Arg Pro Ser Glu Ala Leu Gln Asp Thr Leu Arg Arg Met
         435                 440                 445            
 Gln Leu Glu Arg Arg Pro Pro Asp Phe Leu Arg Leu Leu Arg Leu Ile
     450                 455                 460                
 Arg Asp Met Glu Ala Trp Ala Ala Ser Leu Ala Arg Ser Gln Gln Gly
 465                 470                 475                 480
 Val Ala Trp Ala Ala Ala Pro Val Glu Ser Glu Asp Pro Ala Ala Ala
                 485                 490                 495    
 Gln Ala Ser Pro Ala Gln Gly Asp Ala Ser Glu Ala Asp Pro Gly Ala
             500                 505                 510        
 Glu Asp Ala Asp Glu Ala Ala Ser Thr Thr Lys Glu Ala Ala Arg Val
         515                 520                 525            
 Ala Pro Ala Thr Gly Glu Asp Glu Asn Ala Pro Ala Gly Leu Glu Gly
     530                 535                 540                
 Leu Gly Gln Gly Arg Ser Pro Asp Ala Pro Gly Gly Leu Pro Ala Arg
 545                 550                 555                 560
 Met Gly Ser Ala Val Asp Met Ala Pro Gly Gly Pro Ser Trp Glu Pro
                 565                 570                 575    
 Glu Gly Leu Val Gln Val Gly Gly Gln Glu Ala Glu Glu Pro Pro Gln
             580                 585                 590        
 Glu Gly Leu Lys Pro Ile Leu Glu Glu Ser Glu Asn Glu Asp Glu Asp
         595                 600                 605            
 Gly Ala Gly Glu Ala Gly Lys Pro Lys Ser Pro Pro Gly Lys
     610                 615                 620        



      <210> 799
      <211> 493
      <212> PRT
      <213> Homo sapiens


      <400> 799
 Val Val Leu Ala Gly Ser Arg Asn Arg Ile Leu Arg Thr Arg Thr Phe
   1               5                  10                  15    
 Trp Val Gly Arg Phe Ser Glu Tyr Cys Pro Ser Cys Leu Glu Asn Asp
              20                  25                  30        
 Gln Arg Trp Leu Cys Asn Glu Asn Tyr Lys Val Val Glu Gln Val Pro
          35                  40                  45            
 Thr Lys Lys Asn Phe Ser Ile Leu Ala Arg Asn Leu Asn Thr Ile Gln
      50                  55                  60                
 Val Glu Glu Met Ser Ala Cys Asn Ile Ser Ile Gln Gly Pro Ser Ile
  65                  70                  75                  80
 Tyr Asn Lys Glu Pro Lys Asn Ile Ile Asn Pro His Glu Lys Val Gln
                  85                  90                  95    
 Met Lys Ser Ile Cys Ala Asn Ser Pro Ile Lys Ala Gln Gln Asp Gln
             100                 105                 110        
 Leu Gln Val Lys Asn Asn Ile Lys Ala Ser Leu His Asn Val Lys Ser
         115                 120                 125            
 Ser Leu Pro Leu Phe Asn Thr Lys Ser Ser Thr Ser Val Gly Gln Leu
     130                 135                 140                
 Gln Ser Pro Thr Leu Asn Ser Pro Ile Tyr Met Gln Lys Gln Gly Lys
 145                 150                 155                 160
 Asn Glu His Leu Ala Phe Asn Thr Lys Ser Lys Ala Ser Thr Val Gly
                 165                 170                 175    
 Ser Glu Leu Val Leu Val Ser Thr Thr Val Pro Thr Val His His Val
             180                 185                 190        
 Ser Asp Leu Glu Met Ser Ser Thr Leu Asp Cys Leu Pro Val Leu Ala
         195                 200                 205            
 Asp Trp Glu Asp Val Val Leu Leu Pro Ala Ser Gln Pro Glu Glu Asn
     210                 215                 220                
 Val Asp Cys Thr Val Pro Ile Ser Asp Ser Asp Leu Glu Ile Ser Phe
 225                 230                 235                 240
 Asn Ser Gly Glu Arg Leu Met Val Leu Lys Glu Leu Glu Met Ser Ser
                 245                 250                 255    
 His Glu Asn Phe Gly Asp Ile Glu Glu Thr Pro Gln Lys Ser Glu Thr
             260                 265                 270        
 Ser Lys Ser Ile Val Tyr Lys Ser Pro His Thr Thr Ile Tyr Asn Val
         275                 280                 285            
 Lys Glu Ala Lys Asp Pro Gly Ser Asp Ile Ser Ala Phe Lys Leu Pro
     290                 295                 300                
 Glu His Lys Ser Ser Thr Phe Asn Arg Val Asn Ala Asn Met Ser His
 305                 310                 315                 320
 Pro Leu Val Leu Gly Lys His Pro Leu Leu Ser Gly Gly Thr Lys Arg
                 325                 330                 335    
 Asn Pro Cys Ser Pro Gln Ala Phe Pro Pro Ala Lys Lys Gln Pro Phe
             340                 345                 350        
 Thr Ile His Glu Glu Lys Pro Thr Ser Ser Asp Cys Ser Pro Val Arg
         355                 360                 365            
 Ser Ser Ser Trp Arg Arg Leu Pro Ser Ile Leu Thr Ser Thr Val Asn
     370                 375                 380                
 Leu Gln Glu Pro Trp Lys Ser Gly Lys Met Thr Pro Pro Leu Cys Lys
 385                 390                 395                 400
 Cys Gly Arg Arg Ser Lys Arg Leu Val Val Ser Asn Asn Gly Pro Asn
                 405                 410                 415    
 His Gly Lys Val Phe Tyr Cys Cys Pro Ile Gly Lys Tyr Gln Glu Asn
             420                 425                 430        
 Arg Lys Cys Cys Gly Tyr Phe Lys Trp Glu Gln Thr Leu Gln Lys Glu
         435                 440                 445            
 Arg Ala Asn Ser Met Val Pro Ser His Ser Thr Gly Gly Leu Thr Phe
     450                 455                 460                
 Ser Ser Pro Glu Thr Ser His Ile Cys Asp Arg Asn Leu Ser Ile Ser
 465                 470                 475                 480
 Thr Lys Asn Ser Leu Arg Leu Arg Pro Ser Met Arg Asn
                 485                 490            



      <210> 800
      <211> 424
      <212> PRT
      <213> Homo sapiens


      <400> 800
 Glu Leu Ile Pro Ala Leu Thr Ser Pro Leu Phe Leu Glu Glu Ser Glu
   1               5                  10                  15    
 Lys Ser Arg Ala Glu Gly Ala Pro Asp Thr Gly Arg Gly Arg Ala Arg
              20                  25                  30        
 Gly Ala Trp Arg Val Phe Pro Gly Leu Ser Gly Trp Ser Ala Pro Pro
          35                  40                  45            
 Ala Ser Trp Pro Arg Thr Pro Leu Gln Met Ser Arg Arg Ala Gly Val
      50                  55                  60                
 Thr Lys Met Ser Asp Pro Phe Leu Lys Leu Val Phe Ile Lys Asp Thr
  65                  70                  75                  80
 Thr Phe Arg Pro Lys Arg Lys Leu Glu Pro Gly Thr Gln Arg Leu Glu
                  85                  90                  95    
 Leu His Lys Lys Ala Gln Ala Ser Leu Asn Ala Gly Leu Asp Leu Arg
             100                 105                 110        
 Leu Ala Val Gln Leu Pro Pro Gly Glu Asp Leu Asn Asp Trp Val Ala
         115                 120                 125            
 Val His Val Val Asp Phe Phe Asn Arg Val Asn Leu Ile Tyr Gly Thr
     130                 135                 140                
 Ile Ser Asp Gly Cys Thr Glu Gln Ser Cys Pro Val Met Ser Gly Gly
 145                 150                 155                 160
 Pro Lys Tyr Glu Tyr Arg Trp Gln Asp Glu His Lys Phe Arg Lys Pro
                 165                 170                 175    
 Thr Ala Leu Ser Ala Pro Arg Tyr Met Asp Leu Leu Met Asp Trp Ile
             180                 185                 190        
 Glu Ala Gln Ile Asn Asn Glu Asp Leu Phe Pro Thr Asn Val Gly Thr
         195                 200                 205            
 Pro Phe Pro Lys Asn Phe Leu Gln Thr Val Arg Lys Ile Leu Ser Arg
     210                 215                 220                
 Leu Phe Arg Val Phe Val His Val Tyr Ile His His Phe Asp Arg Ile
 225                 230                 235                 240
 Ala Gln Met Gly Ser Glu Ala His Val Asn Thr Cys Tyr Lys His Phe
                 245                 250                 255    
 Tyr Tyr Phe Val Lys Glu Phe Gly Leu Ile Asp Thr Lys Glu Leu Glu
             260                 265                 270        
 Pro Leu Val Arg Gly Leu Gly Ala Glu Gly Val Arg Leu Arg Trp Arg
         275                 280                 285            
 Pro Arg Leu Glu Leu Gly Pro Gly Asp Pro Ala Asp Gly Thr Ser Gly
     290                 295                 300                
 Glu Val Ala Gly Arg Asp Pro Ala Phe Ser His Gly Thr Asn Ala Gly
 305                 310                 315                 320
 Asp Arg Ser Glu Asn Ala Asp Ser Leu Ala Ser Trp Gly Ser Leu Leu
                 325                 330                 335    
 Pro Leu Val Ser Glu Arg Asn Asp Arg Pro Asp Val Pro Leu Arg Arg
             340                 345                 350        
 Pro Ala Gly Leu Pro Val Pro Glu Pro Pro Leu Gly Pro Arg Arg Leu
         355                 360                 365            
 Gly Gly Gly Arg Ser Gly Thr Ile Ile Pro Leu Leu Ser Gly Leu Ser
     370                 375                 380                
 Ile Ser Gly Arg Pro Gly Ala Glu Pro Leu Ser Arg Cys Trp Ser Ser
 385                 390                 395                 400
 Gly Ala Pro Thr Arg Gly Leu Gln Met Pro Ser Ser Val Ser Ser Leu
                 405                 410                 415    
 Ser Leu Pro Ser Gly Thr Lys Thr
             420                



      <210> 801
      <211> 300
      <212> PRT
      <213> Homo sapiens


      <400> 801
 Cys Cys Pro Cys Ser Pro Arg Ser Trp Pro Pro Pro Ala Arg Cys Arg
   1               5                  10                  15    
 Pro Ser Ala Ala Gly Pro Arg Thr Arg Pro Ala Ser Ser Gly Cys Pro
              20                  25                  30        
 Pro Met Leu Gln Ser Thr Arg Pro Pro Arg Thr Ser Pro Ser Pro Arg
          35                  40                  45            
 Gly Cys Trp Pro Arg Arg Pro Pro Gly Pro Pro Ser Ala Arg Ala Arg
      50                  55                  60                
 Arg Arg Arg Arg Arg Arg Arg Arg Leu Cys Asn Ile Ser Val Gln Arg
  65                  70                  75                  80
 Gln Met Leu Ser Ser Leu Leu Val Arg Trp Gly Arg Pro Arg Gly Phe
                  85                  90                  95    
 Gln Cys Asp Leu Leu Leu Phe Ser Thr Asn Ala His Gly Arg Ala Phe
             100                 105                 110        
 Phe Ala Ala Ala Phe His Arg Val Gly Pro Pro Leu Leu Ile Glu His
         115                 120                 125            
 Leu Gly Leu Ala Ala Gly Gly Ala Gln Gln Asp Leu Arg Leu Cys Val
     130                 135                 140                
 Gly Cys Gly Trp Val Arg Gly Arg Arg Thr Gly Arg Leu Arg Pro Ala
 145                 150                 155                 160
 Ala Ala Pro Ser Ala Ala Ala Ala Thr Ala Gly Ala Pro Thr Ala Leu
                 165                 170                 175    
 Pro Ala Tyr Pro Ala Ala Glu Pro Pro Gly Pro Leu Trp Leu Gln Gly
             180                 185                 190        
 Glu Pro Leu His Phe Cys Cys Leu Asp Phe Ser Leu Glu Glu Leu Gln
         195                 200                 205            
 Gly Glu Pro Gly Trp Arg Leu Asn Arg Lys Pro Ile Glu Ser Thr Leu
     210                 215                 220                
 Val Ala Cys Phe Met Thr Leu Val Ile Val Val Trp Ser Val Ala Ala
 225                 230                 235                 240
 Leu Ile Trp Pro Val Pro Ile Ile Ala Gly Phe Leu Pro Asn Gly Met
                 245                 250                 255    
 Glu Gln Arg Arg Thr Thr Ala Ser Thr Thr Ala Ala Thr Pro Pro Gln
             260                 265                 270        
 Val Pro Ala Gly Thr Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala
         275                 280                 285            
 Ala Ala Ala Ala Val Thr Ser Gly Val Ala Thr Lys
     290                 295                 300



      <210> 802
      <211> 246
      <212> PRT
      <213> Homo sapiens


      <400> 802
 Asn Asn Cys Leu Trp Val Ser Cys Ser Ala Val Gly Ser Glu Arg Arg
   1               5                  10                  15    
 Asn Val Leu Pro Cys His Thr His Ala Leu Pro Cys Glu Arg Ala Arg
              20                  25                  30        
 Glu Arg Glu Arg Gly Arg Ala Arg Glu Cys Ala Ser Pro Arg Arg Ser
          35                  40                  45            
 Gly Thr Ser Ala Ala Ala Arg Gln Arg Gln Gln Leu Arg Arg Arg Pro
      50                  55                  60                
 Thr Gln Gln Arg Glu Ala Arg Gly Gly Cys Leu Glu Glu Ala Ala Ser
  65                  70                  75                  80
 Arg Met Lys Cys Lys Pro Asn Gln Thr Arg Thr Tyr Asp Pro Glu Gly
                  85                  90                  95    
 Phe Lys Lys Arg Ala Ala Cys Leu Cys Phe Arg Ser Glu Arg Glu Asp
             100                 105                 110        
 Glu Val Leu Leu Val Ser Ser Ser Arg Tyr Pro Asp Arg Trp Ile Val
         115                 120                 125            
 Pro Gly Gly Gly Met Glu Pro Glu Glu Glu Pro Gly Gly Ala Ala Val
     130                 135                 140                
 Arg Glu Val Tyr Glu Glu Ala Gly Val Lys Gly Lys Leu Gly Arg Leu
 145                 150                 155                 160
 Leu Gly Val Phe Glu Gln Asn Gln Asp Arg Lys His Arg Thr Tyr Val
                 165                 170                 175    
 Tyr Val Leu Thr Val Thr Glu Leu Leu Glu Asp Trp Glu Asp Ser Val
             180                 185                 190        
 Ser Ile Gly Arg Lys Arg Glu Trp Phe Lys Val Glu Gly Met Gln Ser
         195                 200                 205            
 Lys Val Leu Lys Cys Asn Lys Pro Val Lys Ala Asp Tyr Leu Lys Asn
     210                 215                 220                
 Leu Asn Leu Gly Gly Phe Pro Thr Asn Trp Lys Phe Met Gly Pro Phe
 225                 230                 235                 240
 Leu Ala Asp Ser Asp Ser
                 245    



      <210> 803
      <211> 750
      <212> PRT
      <213> Homo sapiens


      <400> 803
 Pro Lys Ile Ile Lys Arg Lys Ala Cys Leu Leu Met Ile Leu Thr Ser
   1               5                  10                  15    
 Pro Lys Lys Arg Glu Gly Arg Ala Gln Ile Val Val Pro Val Thr Phe
              20                  25                  30        
 Arg Asp Val Thr Val Ile Phe Thr Glu Ala Glu Trp Lys Arg Leu Ser
          35                  40                  45            
 Pro Glu Gln Arg Asn Leu Tyr Lys Glu Val Met Leu Glu Asn Tyr Arg
      50                  55                  60                
 Asn Leu Leu Ser Leu Glu Asn Phe His Ser Ser Ala Glu Pro Lys Pro
  65                  70                  75                  80
 Glu Ile Tyr Thr Cys Ser Ser Cys Leu Leu Ala Phe Ser Cys Gln Gln
                  85                  90                  95    
 Phe Leu Ser Gln His Val Leu Gln Ile Phe Leu Gly Leu Cys Ala Glu
             100                 105                 110        
 Asn His Phe His Pro Gly Asn Ser Ser Pro Gly His Trp Lys Gln Gln
         115                 120                 125            
 Gly Gln Gln Tyr Ser His Val Ser Cys Trp Phe Glu Asn Ala Glu Gly
     130                 135                 140                
 Gln Glu Arg Gly Gly Gly Ser Lys Pro Trp Ser Ala Arg Thr Glu Glu
 145                 150                 155                 160
 Arg Glu Thr Ser Arg Ala Phe Pro Ser Pro Leu Gln Arg Gln Ser Ala
                 165                 170                 175    
 Ser Pro Arg Lys Gly Asn Met Val Val Glu Thr Glu Pro Ser Ser Ala
             180                 185                 190        
 Gln Arg Pro Asn Pro Val Gln Leu Asp Lys Gly Leu Lys Glu Leu Glu
         195                 200                 205            
 Thr Leu Arg Phe Gly Ala Ile Asn Cys Arg Glu Tyr Glu Pro Asp His
     210                 215                 220                
 Asn Leu Glu Ser Asn Phe Ile Thr Asn Pro Arg Thr Leu Leu Gly Lys
 225                 230                 235                 240
 Lys Pro Tyr Ile Cys Ser Asp Cys Gly Arg Ser Phe Lys Asp Arg Ser
                 245                 250                 255    
 Thr Leu Ile Arg His His Arg Ile His Ser Met Glu Lys Pro Tyr Val
             260                 265                 270        
 Cys Ser Glu Cys Gly Arg Gly Phe Ser Gln Lys Ser Asn Leu Ser Arg
         275                 280                 285            
 His Gln Arg Thr His Ser Glu Glu Lys Pro Tyr Leu Cys Arg Glu Cys
     290                 295                 300                
 Gly Gln Ser Phe Arg Ser Lys Ser Ile Leu Asn Arg His Gln Trp Thr
 305                 310                 315                 320
 His Ser Glu Glu Lys Pro Tyr Val Cys Ser Glu Cys Gly Arg Gly Phe
                 325                 330                 335    
 Ser Glu Lys Ser Ser Phe Ile Arg His Gln Arg Thr His Ser Gly Glu
             340                 345                 350        
 Lys Pro Tyr Val Cys Leu Glu Cys Gly Arg Ser Phe Cys Asp Lys Ser
         355                 360                 365            
 Thr Leu Arg Lys His Gln Arg Ile His Ser Gly Glu Lys Pro Tyr Val
     370                 375                 380                
 Cys Arg Glu Cys Gly Arg Gly Phe Ser Gln Asn Ser Asp Leu Ile Lys
 385                 390                 395                 400
 His Gln Arg Thr His Leu Asp Glu Lys Pro Tyr Val Cys Arg Glu Cys
                 405                 410                 415    
 Gly Arg Gly Phe Cys Asp Lys Ser Thr Leu Ile Ile His Glu Arg Thr
             420                 425                 430        
 His Ser Gly Glu Lys Pro Tyr Val Cys Gly Glu Cys Gly Arg Gly Phe
         435                 440                 445            
 Ser Arg Lys Ser Leu Leu Leu Val His Gln Arg Thr His Ser Gly Glu
     450                 455                 460                
 Lys His Tyr Val Cys Arg Glu Cys Arg Arg Gly Phe Ser Gln Lys Ser
 465                 470                 475                 480
 Asn Leu Ile Arg His Gln Arg Thr His Ser Asn Glu Lys Pro Tyr Ile
                 485                 490                 495    
 Cys Arg Glu Cys Gly Arg Gly Phe Cys Asp Lys Ser Thr Leu Ile Val
             500                 505                 510        
 His Glu Arg Thr His Ser Gly Glu Lys Pro Tyr Val Cys Arg Cys Met
         515                 520                 525            
 Gly Lys Ala Phe Val Ile Thr His His Arg Glu Asn Leu His Val Gly
     530                 535                 540                
 Thr Leu Trp Ser Ser Ala Gln Met Thr Phe Ser Gly Val Thr Pro Gln
 545                 550                 555                 560
 Leu Leu Glu Arg Thr Val Leu Leu Leu Ala Glu Met His Ser Arg Asp
                 565                 570                 575    
 Ala Leu Arg Ser Gly Thr His Ser Gln Pro Gln Gly Ala Ala Cys Thr
             580                 585                 590        
 Thr Gly Ala Met His Leu Cys Arg Gly Thr Phe Trp Pro Gln Pro Leu
         595                 600                 605            
 Thr Gln Arg Gly Gln Leu Gln Lys Val Ile Pro Asp Pro Glu Ile Pro
     610                 615                 620                
 Ile Glu Leu Lys Asp His Trp Val Ala Asp Thr Leu Gln Val Pro Pro
 625                 630                 635                 640
 Ile Asn Leu Ile Ile Met Ala Ile Glu Phe Gln His Glu Phe Trp Arg
                 645                 650                 655    
 Arg His Ser His His Ser Ile Asn Tyr Ala Val Ala Pro Gln Ser Gly
             660                 665                 670        
 Leu Met Arg Glu Lys Asp Val His Val Trp Glu Cys Gly Pro Pro Pro
         675                 680                 685            
 Phe Ala Arg Thr Ala Pro Ile Thr Pro Thr Ser Asp Gln Asn Trp Arg
     690                 695                 700                
 Pro Leu Arg Glu Lys Lys Gly His Tyr Gln Asp Leu Ser Thr Pro Ser
 705                 710                 715                 720
 Gln Lys Glu Thr Glu Leu Lys Arg Thr Arg Val Ser Leu Arg Arg Lys
                 725                 730                 735    
 Arg Asp Ala Asn Ser Pro Leu Gln Asp Tyr Gly Phe Gly Ala
             740                 745                 750



      <210> 804
      <211> 104
      <212> PRT
      <213> Homo sapiens


      <400> 804
 Thr Ala Gly Phe Ile Trp Leu Phe Lys His His Arg Phe Leu Lys Lys
   1               5                  10                  15    
 Thr Lys Gln Lys Leu Thr Val Cys Pro Ile Ile Asn Gly Glu Asp His
              20                  25                  30        
 Leu Arg Leu Leu Asn Phe Gln His Asn Phe Ile Thr Arg Ile Gln Asn
          35                  40                  45            
 Ile Ser Asn Leu Gln Lys Leu Ile Ser Leu Asp Leu Tyr Asp Asn Gln
      50                  55                  60                
 Ile Glu Glu Ile Ser Gly Leu Ser Thr Leu Arg Cys Leu Arg Val Leu
  65                  70                  75                  80
 Leu Val Gly Lys Asn Arg Ile Gln Lys Asn Leu His Leu Glu Asn Leu
                  85                  90                  95    
 Lys Lys Pro Lys Arg Pro Trp Ile
             100                



      <210> 805
      <211> 36
      <212> PRT
      <213> Homo sapiens


      <400> 805
 Ser Cys Ser Gly Asp Met Ala Gly Val Lys Ala Leu Val Ala Leu Ser
   1               5                  10                  15    
 Phe Ser Gly Ala Ile Gly Leu Thr Phe Leu Met Leu Gly Cys Ala Leu
              20                  25                  30        
 Glu Asp Tyr Gly
          35    



      <210> 806
      <211> 445
      <212> PRT
      <213> Homo sapiens


      <400> 806
 Met Ala Ser Ser Lys Leu Arg Glu Pro Val Asp Glu Val Phe Asp Leu
   1               5                  10                  15    
 Asp Leu Ala Val Pro Glu Thr Ala Arg Leu Asp Ser Ser Leu His Lys
              20                  25                  30        
 Ala Arg Ala Gln Leu Leu Ala Lys Gly Arg Arg His Arg Pro Ser Arg
          35                  40                  45            
 Ser Arg Leu Arg Asp Ser Ala Ser Ser Ala Glu Asp Gly Glu Gly Ser
      50                  55                  60                
 Asp Gly Pro Gly Gly Lys Val Thr Asp Gly Cys Gly Ser Pro Leu His
  65                  70                  75                  80
 Arg Leu Arg Ser Pro Leu His Ser Gly Pro Gly Ser Pro Ala Gly Gly
                  85                  90                  95    
 Ser Phe Cys Leu Asp Pro Pro Gly Leu Arg Arg Ser Leu Asp Glu Asp
             100                 105                 110        
 Glu Pro Pro Pro Ser Pro Leu Thr Arg Tyr Arg Pro Leu His Asn Ala
         115                 120                 125            
 Ala Ser His Glu Gly Leu Ala Ala Ala Ser Cys Ser Pro Pro Arg Ser
     130                 135                 140                
 Ala Pro Ser Ser Asp Ser Ser Pro Ser Phe Val Arg Arg His Pro Arg
 145                 150                 155                 160
 Ala Glu Pro His Ser Glu Asp Asp Ser Arg Asp Ala Ser Pro Pro Glu
                 165                 170                 175    
 Pro Ala Ser Pro Thr Ile Gly Leu Asp Lys Lys Thr Arg Arg Lys Phe
             180                 185                 190        
 Leu Asp Leu Gly Val Thr Leu Arg Arg Ala Ser Thr Gly Lys Ser Arg
         195                 200                 205            
 Lys Glu Lys Gly Ser Asn Arg Leu Ser Met Gly Ser Arg Glu Ser Val
     210                 215                 220                
 Glu Gly Ser Gly Arg Ser Gly Gly Ser Pro Phe Leu Pro Phe Ser Trp
 225                 230                 235                 240
 Phe Thr Asp Ser Gly Lys Gly Ser Ala Ser Ser Gly Ser Thr Thr Ser
                 245                 250                 255    
 Pro Thr Cys Ser Pro Lys His Glu Gly Phe Ser Pro Lys Lys Ser Ala
             260                 265                 270        
 Ser Gln Ala Gln Leu Leu Ala His Ala Gln Glu Ala Leu Ser Asn Ser
         275                 280                 285            
 Trp Cys Leu Val Gln Asp Phe Gly Ser Thr Gln Ile Gly Met Glu Ser
     290                 295                 300                
 Thr Leu Ser Asp Asp Ser Thr Pro Pro Ser Ser Ser Pro Lys Ile Pro
 305                 310                 315                 320
 Ser Gly Pro Trp Gln Glu Ala Lys Cys Ser Tyr Pro Tyr His Thr Leu
                 325                 330                 335    
 Ser Gln Ser Ser Asp Glu Phe Leu Asp Glu Pro Leu Pro Pro Val His
             340                 345                 350        
 His Trp Thr Ser Gln Gln Val Gly Gln Trp Leu Gln Ser Leu Asn Leu
         355                 360                 365            
 Glu Gln Tyr Ala Ala Glu Phe Ala Ala Arg Gln Val Asp Gly Pro Gln
     370                 375                 380                
 Leu Leu Gln Leu Asp Gly Ser Lys Leu Lys Ser Leu Gly Leu Ser Asn
 385                 390                 395                 400
 Ser His Asp Arg Ala Leu Val Lys Arg Lys Leu Lys Glu Met Ala Ala
                 405                 410                 415    
 Ala Ala Glu Lys Glu Arg Lys Ala Gln Glu Lys Ala Ala Arg Gln Arg
             420                 425                 430        
 Glu Lys Leu Arg Arg Arg Glu Gln Glu Ala Lys Lys Ser
         435                 440                 445



      <210> 807
      <211> 63
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(63)
      <223> Xaa = any amino acid or nothing 


      <400> 807
 Lys Ser Glu Ser Gly Ser Phe Ala Asp Ala Ser Arg Cys Asp Pro Ala
   1               5                  10                  15    
 His Ser Gln Val Trp Trp Leu Arg Gly Glu Thr Thr Ser Ala Xaa Glu
              20                  25                  30        
 Glu Gln Arg Glu Glu Xaa Arg Gly Leu Arg Leu Glu Leu Arg Tyr Gln
          35                  40                  45            
 Leu Ser His Ser Gly Lys Glu His Gln Ala Ser Ser Leu Gly Pro
      50                  55                  60            



      <210> 808
      <211> 143
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(143)
      <223> Xaa = any amino acid or nothing 


      <400> 808
 Ile Gln Ser Val Phe Val Arg Ser Ser Phe Gly Leu Leu Ala Val Thr
   1               5                  10                  15    
 Pro Ala Cys Cys Leu Leu Arg Leu Ile Ser Ser Trp Val His Leu Ser
              20                  25                  30        
 Arg Ser Leu Ala Gly Leu Ser Thr Leu Pro Asp Gln Lys Leu Ser Trp
          35                  40                  45            
 His Ala Gln Arg Asn Ser Thr His Met Ser Arg Trp Leu Arg Pro Ser
      50                  55                  60                
 Arg Ser Arg Ile Arg Arg Ile Ser Leu Ala His Pro Ala Lys Phe Gly
  65                  70                  75                  80
 Phe Arg Leu Met Val Arg Xaa Ser Ser Pro Cys Gln Thr Ser Thr Leu
                  85                  90                  95    
 Arg Arg Ser Gly Leu Leu Leu Ser Pro Thr Cys Cys Arg Ser Glu Leu
             100                 105                 110        
 Gln His Pro Val Ser Pro Gln Lys Gly Arg Phe Leu Ala Gly Gln Arg
         115                 120                 125            
 Ile Arg Gln Asn Ser Leu Thr Asn Asn Leu Phe Phe Phe Leu Leu
     130                 135                 140            



      <210> 809
      <211> 730
      <212> PRT
      <213> Homo sapiens


      <400> 809
 Met Pro Glu Pro Pro Pro Ala Pro Gly Ser Cys Ala Ala Arg Ala Ser
   1               5                  10                  15    
 Lys Thr Ser Ala Ala Pro Gly Ser Thr Ala Pro Ser Pro Ile His Arg
              20                  25                  30        
 Ser Arg Ala Glu Glu Arg Gly Thr Thr Ala Arg Asn Trp Gln Ala Ala
          35                  40                  45            
 Pro Thr Ala Ala Pro Val Arg Asp Pro Leu Gly Glu Ala Ser Trp Ala
      50                  55                  60                
 Pro Glu Ser Ala Asn Leu Val Gly Ile Trp Arg Thr Phe Val Ser Ser
  65                  70                  75                  80
 Ser Gly Ile Val Asn Ala Pro Ile Ser Thr Leu Ser Lys Arg Thr Asn
                  85                  90                  95    
 Gln Leu Ser Val Lys Gln Thr Asn Arg Leu Ser Val Lys Trp Thr Asn
             100                 105                 110        
 Gln Gln Asp Val Ala Arg Gly Ser Ala Thr Tyr Arg Glu Gly Glu His
         115                 120                 125            
 Gly Cys Trp Leu Leu Ala Pro Gly Gly Phe Arg Ala Leu Gln Leu Asp
     130                 135                 140                
 Asn Cys Arg Asp Gly Val Cys Val Arg Asp Pro Leu Arg Gln Val Leu
 145                 150                 155                 160
 Gly Glu Ala Pro Pro Leu Gln Leu Ala Cys Arg Phe Pro Pro Gly Thr
                 165                 170                 175    
 Pro Ala Ala Ser Pro Glu Arg Gly Pro Gly Ala Glu Lys Arg Val Cys
             180                 185                 190        
 Gly Lys Asp Val Ser Glu Val Thr His Cys Thr His Asp Leu Leu His
         195                 200                 205            
 Ala Thr Leu Glu Asp Ser Trp Asp Val Ser Ser Gln Leu Asp Arg Gln
     210                 215                 220                
 Gln Glu Asn Trp Lys Arg His Leu Gly Ser Glu Ala Ser Thr Gln Lys
 225                 230                 235                 240
 Lys Ile Ile Thr Pro Gln Glu Asn Phe Glu Gln Asn Lys Phe Gly Glu
                 245                 250                 255    
 Asn Ser Arg Leu Asn Thr Asn Leu Val Thr Gln Leu Asn Ile Pro Ala
             260                 265                 270        
 Arg Ile Arg Pro Ser Glu Cys Glu Thr Leu Gly Ser Asn Leu Gly His
         275                 280                 285            
 Asn Ala Asp Leu Leu Asn Glu Asn Asn Ile Leu Ala Lys Lys Lys Pro
     290                 295                 300                
 Tyr Lys Cys Asp Lys Cys Arg Lys Ala Phe Ile His Arg Ser Ser Leu
 305                 310                 315                 320
 Thr Lys His Glu Lys Thr His Lys Gly Glu Gly Ala Phe Pro Asn Gly
                 325                 330                 335    
 Thr Asp Gln Gly Ile Tyr Pro Gly Lys Lys His His Glu Cys Thr Asp
             340                 345                 350        
 Cys Gly Lys Thr Phe Leu Trp Lys Thr Gln Leu Thr Glu His Gln Arg
         355                 360                 365            
 Ile His Thr Gly Glu Lys Pro Phe Glu Cys Asn Val Cys Gly Lys Ala
     370                 375                 380                
 Phe Arg His Ser Ser Ser Leu Gly Gln His Glu Asn Ala His Thr Gly
 385                 390                 395                 400
 Glu Lys Pro Tyr Gln Cys Ser Leu Cys Gly Lys Ala Phe Gln Arg Ser
                 405                 410                 415    
 Ser Ser Leu Val Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr
             420                 425                 430        
 Arg Cys Asn Leu Cys Gly Arg Ser Phe Arg His Gly Thr Ser Leu Thr
         435                 440                 445            
 Gln His Glu Val Thr His Ser Gly Glu Lys Pro Phe Gln Cys Lys Glu
     450                 455                 460                
 Cys Gly Lys Ala Phe Ser Arg Cys Ser Ser Leu Val Gln His Glu Arg
 465                 470                 475                 480
 Thr His Thr Gly Glu Lys Pro Phe Glu Cys Ser Ile Cys Gly Arg Ala
                 485                 490                 495    
 Phe Gly Gln Ser Pro Ser Leu Tyr Lys His Met Arg Ile His Lys Arg
             500                 505                 510        
 Gly Lys Pro Tyr Gln Ser Ser Asn Tyr Ser Ile Asp Phe Lys His Ser
         515                 520                 525            
 Thr Ser Leu Thr Gln Asp Glu Ser Thr Leu Thr Glu Val Lys Ser Tyr
     530                 535                 540                
 His Cys Asn Asp Cys Gly Glu Asp Phe Ser His Ile Thr Asp Phe Thr
 545                 550                 555                 560
 Asp His Gln Arg Ile His Thr Ala Glu Asn Pro Tyr Asp Cys Glu Gln
                 565                 570                 575    
 Ala Phe Ser Gln Gln Ala Ile Ser His Pro Gly Glu Lys Pro Tyr Gln
             580                 585                 590        
 Cys Asn Val Cys Gly Lys Ala Phe Lys Arg Ser Thr Ser Phe Ile Glu
         595                 600                 605            
 His His Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys
     610                 615                 620                
 Gly Glu Ala Phe Ser Arg Arg Ser Ser Leu Thr Gln His Glu Arg Thr
 625                 630                 635                 640
 His Thr Gly Glu Lys Pro Tyr Glu Cys Ile Asp Cys Gly Lys Ala Phe
                 645                 650                 655    
 Ser Gln Ser Ser Ser Leu Ile Gln His Glu Arg Thr His Thr Gly Glu
             660                 665                 670        
 Lys Pro Tyr Glu Cys Asn Glu Cys Gly Arg Ala Phe Arg Lys Lys Thr
         675                 680                 685            
 Asn Leu His Asp His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Ser
     690                 695                 700                
 Cys Lys Glu Cys Gly Lys Asn Phe Ser Arg Ser Ser Ala Leu Thr Lys
 705                 710                 715                 720
 His Gln Arg Ile His Thr Arg Asn Lys Leu
                 725                 730



      <210> 810
      <211> 148
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(148)
      <223> Xaa = any amino acid or nothing 


      <400> 810
 Met Pro Ile Leu Phe Thr Thr Val Ser Ser Ala Leu Ser Gly Ala Gln
   1               5                  10                  15    
 His Ile Ala Asp Ala Gln Cys Asp Arg Lys Gly His Arg Thr Thr Ile
              20                  25                  30        
 Gln Gly Ser Arg Val Asn Leu Val Gln Pro Ser Val Gly Pro Lys Val
          35                  40                  45            
 Glu Glu Thr Gln Cys Trp Gly Pro Gly Arg Gly Met Pro Gly Ala Pro
      50                  55                  60                
 Glu Ala Pro Arg Glu Arg Arg Val Arg Ser Gly Ser Arg Ser Gly Asp
  65                  70                  75                  80
 Pro Gly Val Ala Pro Arg Ala Ala Ser Gly Val Gly Gly Arg Tyr Ala
                  85                  90                  95    
 Ile Thr Arg Gly Arg Ala Ser Ala Ala Val Pro Cys Arg Ser Gly Gly
             100                 105                 110        
 Ala Arg Arg Gly Gly Ala Gly Gly Gln Ala Ala Asp Cys Gly Pro Gly
         115                 120                 125            
 His Xaa Lys Glu Ser Glu Ser Arg Gly Pro Glu Gly Pro Ala Glu Gly
     130                 135                 140                
 Ser Gln Pro Leu
 145            



      <210> 811
      <211> 163
      <212> PRT
      <213> Homo sapiens


      <400> 811
 Leu Lys Asp Val Ile Thr Leu Arg Arg His Val Glu Thr Lys Val Arg
   1               5                  10                  15    
 Ala Lys Ile Arg Lys Arg Lys Val Thr Thr Lys Ile Asn Arg His Asp
              20                  25                  30        
 Lys Ile Asn Gly Lys Arg Lys Thr Ala Arg Lys Gln Lys Met Phe Gln
          35                  40                  45            
 Arg Ala Gln Glu Leu Arg Arg Arg Ala Glu Asp Tyr His Lys Cys Lys
      50                  55                  60                
 Ile Pro Pro Ser Ala Arg Lys Pro Leu Cys Asn Trp Val Ser Leu Phe
  65                  70                  75                  80
 Val Phe Leu Ala Phe Glu His Ser Leu Pro Gly Gln Asp Met Asp Thr
                  85                  90                  95    
 Phe Phe Ser Leu Gln Leu Cys Ala Gln Ala Leu Gln Arg Glu Met Ala
             100                 105                 110        
 Glu Arg Lys Ala Ala Tyr Ser Ile Thr Val Pro Ser Leu Leu Val Thr
         115                 120                 125            
 Val Leu Cys Lys Asn Thr Phe Ile Pro Thr Gln Trp Ala Pro Asp Leu
     130                 135                 140                
 Asn Ser Lys Cys Gln Arg Phe His Ile Cys Asn Ser Lys Trp Ala Leu
 145                 150                 155                 160
 Thr Val Asn
            



      <210> 812
      <211> 163
      <212> PRT
      <213> Homo sapiens


      <400> 812
 Leu Lys Asp Val Ile Thr Leu Arg Arg His Val Glu Thr Lys Val Arg
   1               5                  10                  15    
 Ala Lys Ile Arg Lys Arg Lys Val Thr Thr Lys Ile Asn Arg His Asp
              20                  25                  30        
 Lys Ile Asn Gly Lys Arg Lys Thr Ala Arg Lys Gln Lys Met Phe Gln
          35                  40                  45            
 Arg Ala Gln Glu Leu Arg Arg Arg Ala Glu Asp Tyr His Lys Cys Lys
      50                  55                  60                
 Ile Pro Pro Ser Ala Arg Lys Pro Leu Cys Asn Trp Val Ser Leu Phe
  65                  70                  75                  80
 Val Phe Leu Ala Phe Glu His Ser Leu Pro Gly Gln Asp Met Asp Thr
                  85                  90                  95    
 Phe Phe Ser Leu Gln Leu Cys Ala Gln Ala Leu Gln Arg Glu Met Ala
             100                 105                 110        
 Glu Arg Lys Ala Ala Tyr Ser Ile Thr Val Pro Ser Leu Leu Val Thr
         115                 120                 125            
 Val Leu Cys Lys Asn Thr Phe Ile Pro Thr Gln Trp Ala Pro Asp Leu
     130                 135                 140                
 Asn Ser Lys Cys Gln Arg Phe His Ile Cys Asn Ser Lys Trp Ala Leu
 145                 150                 155                 160
 Thr Val Asn
            



      <210> 813
      <211> 163
      <212> PRT
      <213> Homo sapiens


      <400> 813
 Leu Lys Asp Val Ile Thr Leu Arg Arg His Val Glu Thr Lys Val Arg
   1               5                  10                  15    
 Ala Lys Ile Arg Lys Arg Lys Val Thr Thr Lys Ile Asn Arg His Asp
              20                  25                  30        
 Lys Ile Asn Gly Lys Arg Lys Thr Ala Arg Lys Gln Lys Met Phe Gln
          35                  40                  45            
 Arg Ala Gln Glu Leu Arg Arg Arg Ala Glu Asp Tyr His Lys Cys Lys
      50                  55                  60                
 Ile Pro Pro Ser Ala Arg Lys Pro Leu Cys Asn Trp Val Ser Leu Phe
  65                  70                  75                  80
 Val Phe Leu Ala Phe Glu His Ser Leu Pro Gly Gln Asp Met Asp Thr
                  85                  90                  95    
 Phe Phe Ser Leu Gln Leu Cys Ala Gln Ala Leu Gln Arg Glu Met Ala
             100                 105                 110        
 Glu Arg Lys Ala Ala Tyr Ser Ile Thr Val Pro Ser Leu Leu Val Thr
         115                 120                 125            
 Val Leu Cys Lys Asn Thr Phe Ile Pro Thr Gln Trp Ala Pro Asp Leu
     130                 135                 140                
 Asn Ser Lys Cys Gln Arg Phe His Ile Cys Asn Ser Lys Trp Ala Leu
 145                 150                 155                 160
 Thr Val Asn
            



      <210> 814
      <211> 163
      <212> PRT
      <213> Homo sapiens


      <400> 814
 Leu Lys Asp Val Ile Thr Leu Arg Arg His Val Glu Thr Lys Val Arg
   1               5                  10                  15    
 Ala Lys Ile Arg Lys Arg Lys Val Thr Thr Lys Ile Asn Arg His Asp
              20                  25                  30        
 Lys Ile Asn Gly Lys Arg Lys Thr Ala Arg Lys Gln Lys Met Phe Gln
          35                  40                  45            
 Arg Ala Gln Glu Leu Arg Arg Arg Ala Glu Asp Tyr His Lys Cys Lys
      50                  55                  60                
 Ile Pro Pro Ser Ala Arg Lys Pro Leu Cys Asn Trp Val Ser Leu Phe
  65                  70                  75                  80
 Val Phe Leu Ala Phe Glu His Ser Leu Pro Gly Gln Asp Met Asp Thr
                  85                  90                  95    
 Phe Phe Ser Leu Gln Leu Cys Ala Gln Ala Leu Gln Arg Glu Met Ala
             100                 105                 110        
 Glu Arg Lys Ala Ala Tyr Ser Ile Thr Val Pro Ser Leu Leu Val Thr
         115                 120                 125            
 Val Leu Cys Lys Asn Thr Phe Ile Pro Thr Gln Trp Ala Pro Asp Leu
     130                 135                 140                
 Asn Ser Lys Cys Gln Arg Phe His Ile Cys Asn Ser Lys Trp Ala Leu
 145                 150                 155                 160
 Thr Val Asn
            



      <210> 815
      <211> 1271
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1271)
      <223> Xaa = any amino acid or nothing 


      <400> 815
 Met Val Gly Glu Leu Arg Tyr Arg Glu Phe Arg Val Pro Leu Gly Pro
   1               5                  10                  15    
 Gly Leu His Ala Tyr Pro Asp Glu Leu Ile Arg Gln Arg Val Gly His
              20                  25                  30        
 Asp Gly His Pro Glu Tyr Gln Ile Arg Trp Leu Ile Leu Arg Arg Gly
          35                  40                  45            
 Asp Glu Gly Asp Gly Gly Ser Gly Gln Val Asp Cys Lys Ala Glu His
      50                  55                  60                
 Ile Leu Leu Trp Met Ser Lys Asp Glu Ile Tyr Ala Asn Cys His Lys
  65                  70                  75                  80
 Met Leu Gly Glu Asp Gly Gln Val Ile Gly Pro Ser Gln Glu Ser Ala
                  85                  90                  95    
 Gly Glu Val Gly Ala Leu Asp Lys Ser Val Leu Glu Glu Met Glu Thr
             100                 105                 110        
 Asp Val Lys Ser Leu Ile Gln Arg Ala Leu Arg Gln Leu Glu Glu Cys
         115                 120                 125            
 Val Gly Thr Ile Pro Pro Ala Pro Leu Leu His Thr Val His Val Leu
     130                 135                 140                
 Ser Ala Tyr Ala Ser Ile Glu Pro Leu Thr Gly Val Phe Lys Asp Pro
 145                 150                 155                 160
 Arg Val Leu Asp Leu Leu Met His Met Leu Ser Ser Pro Asp Tyr Gln
                 165                 170                 175    
 Ile Arg Trp Ser Ala Gly Arg Met Ile Gln Ala Leu Ser Ser His Asp
             180                 185                 190        
 Ala Gly Thr Arg Thr Gln Ile Leu Leu Ser Leu Ser Gln Gln Glu Ala
         195                 200                 205            
 Ile Glu Lys His Leu Asp Phe Asp Ser Arg Cys Ala Leu Leu Ala Leu
     210                 215                 220                
 Phe Ala Gln Ala Thr Leu Ser Glu His Pro Met Ser Phe Glu Gly Ile
 225                 230                 235                 240
 Gln Leu Pro Gln Val Pro Gly Arg Val Leu Phe Ser Leu Val Lys Arg
                 245                 250                 255    
 Tyr Leu His Val Thr Ser Leu Leu Asp Gln Leu Asn Asp Ser Ala Ala
             260                 265                 270        
 Glu Pro Gly Ala Gln Asn Thr Ser Ala Pro Glu Glu Leu Ser Gly Glu
         275                 280                 285            
 Arg Gly Gln Leu Glu Leu Glu Phe Ser Met Ala Met Gly Thr Leu Ile
     290                 295                 300                
 Ser Glu Leu Val Gln Ala Met Arg Trp Asp Gln Ala Ser Asp Arg Pro
 305                 310                 315                 320
 Arg Ser Ser Ala Arg Ser Pro Gly Ser Ile Phe Gln Pro Gln Leu Ala
                 325                 330                 335    
 Asp Val Ser Pro Gly Leu Pro Ala Ala Gln Ala Gln Pro Ser Phe Arg
             340                 345                 350        
 Arg Ser Arg Arg Phe Arg Pro Arg Ser Glu Phe Ala Ser Gly Asn Thr
         355                 360                 365            
 Tyr Ala Leu Tyr Val Arg Asp Thr Leu Gln Pro Gly Met Arg Val Arg
     370                 375                 380                
 Met Leu Asp Asp Tyr Glu Glu Ile Ser Ala Gly Asp Glu Gly Glu Phe
 385                 390                 395                 400
 Arg Gln Ser Asn Asn Gly Val Pro Pro Val Gln Val Phe Trp Glu Ser
                 405                 410                 415    
 Thr Gly Arg Thr Tyr Trp Val His Trp His Met Leu Glu Ile Leu Gly
             420                 425                 430        
 Phe Glu Glu Asp Ile Glu Asp Met Val Glu Ala Asp Glu Tyr Gln Gly
         435                 440                 445            
 Ala Val Ala Ser Arg Val Leu Gly Arg Ala Leu Pro Ala Trp Arg Trp
     450                 455                 460                
 Arg Pro Met Thr Glu Leu Tyr Ala Val Pro Tyr Val Leu Pro Glu Asp
 465                 470                 475                 480
 Glu Asp Thr Glu Glu Cys Glu His Leu Thr Leu Ala Glu Trp Trp Glu
                 485                 490                 495    
 Leu Leu Phe Phe Ile Lys Lys Leu Asp Gly Pro Asp His Gln Glu Val
             500                 505                 510        
 Leu Gln Ile Leu Gln Glu Asn Leu Asp Gly Glu Ile Leu Asp Asp Glu
         515                 520                 525            
 Ile Leu Ala Glu Leu Ala Val Pro Ile Glu Leu Ala Gln Asp Leu Leu
     530                 535                 540                
 Leu Thr Leu Pro Gln Arg Leu Asn Asp Ser Ala Leu Arg Asp Leu Ile
 545                 550                 555                 560
 Asn Cys His Val Tyr Lys Lys Tyr Gly Pro Glu Ala Leu Ala Gly Asn
                 565                 570                 575    
 Gln Ala Tyr Pro Ser Leu Leu Glu Ala Gln Glu Asp Val Leu Leu Leu
             580                 585                 590        
 Asp Ala Gln Ala Gln Ala Lys Asp Ser Glu Asp Ala Ala Lys Val Glu
         595                 600                 605            
 Ala Lys Glu Pro Pro Ser Gln Ser Pro Asn Thr Pro Leu Gln Arg Leu
     610                 615                 620                
 Val Glu Gly Tyr Gly Pro Ala Gly Lys Ile Leu Leu Asp Leu Glu Gln
 625                 630                 635                 640
 Ala Leu Ser Ser Glu Gly Thr Gln Glu Asn Lys Val Lys Pro Leu Leu
                 645                 650                 655    
 Leu Gln Leu Gln Arg Gln Pro Gln Pro Phe Leu Ala Leu Met Gln Ser
             660                 665                 670        
 Leu Asp Thr Pro Glu Thr Asn Arg Thr Leu His Leu Thr Val Leu Arg
         675                 680                 685            
 Ile Leu Lys Gln Leu Val Asp Phe Pro Glu Ala Leu Leu Leu Pro Trp
     690                 695                 700                
 His Glu Ala Val Asp Ala Cys Met Ala Cys Leu Arg Ser Pro Asn Thr
 705                 710                 715                 720
 Asp Arg Glu His Pro Val His Arg Val His Ser Gly Thr Cys Tyr Cys
                 725                 730                 735    
 Ser Ala Pro Val Ala Phe Ala Leu Phe His Ser Ser Pro Pro Leu Cys
             740                 745                 750        
 Pro His Pro Gly Ala Pro Gly Thr Asp Phe Phe Leu His Arg Leu Thr
         755                 760                 765            
 Ser Val Ser Arg Asp Tyr Ala Val Val Leu Asn Gln Leu Gly Ala Arg
     770                 775                 780                
 Asp Ala Ile Ser Lys Ala Leu Glu Lys His Leu Gly Lys Leu Glu Leu
 785                 790                 795                 800
 Ala Gln Glu Leu Arg Asp Met Val Phe Lys Cys Glu Lys His Ala His
                 805                 810                 815    
 Leu Tyr Arg Lys Leu Ile Thr Asn Ile Leu Gly Gly Cys Ile Gln Met
             820                 825                 830        
 Val Leu Gly Gln Ile Glu Asp His Arg Arg Thr His Gln Pro Ile Asn
         835                 840                 845            
 Ile Pro Phe Phe Asp Val Phe Leu Arg Tyr Leu Cys Gln Gly Ser Ser
     850                 855                 860                
 Val Glu Val Lys Glu Asp Lys Cys Trp Glu Lys Val Glu Val Ser Ser
 865                 870                 875                 880
 Asn Pro His Arg Ala Ser Lys Leu Thr Asp His Asn Pro Lys Thr Tyr
                 885                 890                 895    
 Trp Glu Ser Asn Gly Ser Ala Gly Ser His Tyr Ile Thr Leu His Met
             900                 905                 910        
 Arg Arg Gly Ile Leu Ile Arg Gln Leu Thr Leu Leu Val Ala Ser Glu
         915                 920                 925            
 Asp Ser Ser Tyr Met Pro Ala Arg Val Val Val Cys Gly Gly Asp Ser
     930                 935                 940                
 Thr Ser Ser Leu His Thr Glu Leu Asn Ser Val Asn Val Met Pro Ser
 945                 950                 955                 960
 Ala Ser Arg Val Ile Leu Leu Glu Asn Leu Thr Arg Phe Trp Pro Ile
                 965                 970                 975    
 Ile Gln Ile Arg Ile Lys Arg Cys Gln Gln Gly Gly Ile Asp Thr Arg
             980                 985                 990        
 Ile Arg Gly Leu Glu Ile Leu Gly Pro Lys Pro Thr Phe Trp Pro Val
         995                1000                1005            
 Phe Arg Glu Gln Leu Cys Arg His Thr Arg Leu Phe Tyr Met Val Arg
    1010                1015                1020                
 Ala Gln Ala Trp Ser Gln Asp Met Ala Glu Asp Arg Arg Ser Leu Leu
1025                1030                1035                1040
 His Leu Ser Ser Arg Leu Asn Gly Ala Leu Arg Gln Glu Gln Asn Phe
                1045                1050                1055    
 Ala Asp Arg Phe Leu Pro Asp Asp Glu Ala Ala Gln Ala Leu Gly Lys
            1060                1065                1070        
 Thr Cys Trp Glu Ala Leu Val Ser Pro Val Val Gln Asn Ile Thr Ser
        1075                1080                1085            
 Pro Asp Glu Asp Gly Ile Ser Pro Leu Gly Trp Leu Leu Asp Gln Tyr
    1090                1095                1100                
 Leu Glu Cys Gln Glu Ala Val Phe Asn Pro Gln Ser Arg Gly Pro Ala
1105                1110                1115                1120
 Phe Phe Ser Arg Val Arg Arg Leu Thr His Leu Leu Val His Val Glu
                1125                1130                1135    
 Pro Cys Glu Ala Pro Pro Pro Val Val Ala Thr Pro Arg Pro Lys Gly
            1140                1145                1150        
 Arg Asn Arg Ser His Asp Trp Ser Ser Leu Ala Thr Arg Gly Leu Pro
        1155                1160                1165            
 Ser Ser Ile Met Arg Asn Leu Thr Arg Cys Trp Arg Ala Val Val Glu
    1170                1175                1180                
 Lys Gln Val Asn Asn Phe Leu Thr Ser Ser Trp Arg Asp Asp Asp Phe
1185                1190                1195                1200
 Val Pro Arg Tyr Cys Glu His Phe Asn Ile Leu Gln Asn Ser Ser Ser
                1205                1210                1215    
 Glu Leu Phe Gly Pro Arg Ala Ala Phe Leu Leu Ala Leu Gln Asn Gly
            1220                1225                1230        
 Cys Ala Gly Ala Leu Leu Lys Leu Pro Phe Leu Lys Ala Ala His Glu
        1235                1240                1245            
 Gln Gln Glu Met Ala Gln Gln Glu Arg Lys Gln Gln Gln Glu Leu His
    1250                1255                1260                
 Leu Ala Leu Lys Gln Glu Xaa
1265                1270    



      <210> 816
      <211> 45
      <212> PRT
      <213> Homo sapiens


      <400> 816
 Ile Leu Lys Val Val Ser Asp Phe Phe Ala Arg Ser Trp Lys Asn Thr
   1               5                  10                  15    
 Phe His Phe Gln Ile Leu His Lys Gly Leu Ser Leu His His Gly Leu
              20                  25                  30        
 Glu Asp Ala Tyr Asp Val Ala Ser Arg Gly Ser Phe His
          35                  40                  45



      <210> 817
      <211> 279
      <212> PRT
      <213> Homo sapiens


      <400> 817
 Gly Lys Arg Leu Leu Gly Pro Gln Trp Leu Asp Tyr Asp Cys Asp Arg
   1               5                  10                  15    
 Ala Val Ile Glu Asp Trp Val Phe Arg Val Pro His Val Ala Ile Phe
              20                  25                  30        
 Leu Ser Val Val Ile Cys Lys Gly Phe Leu Val Leu Cys Ser Ser Leu
          35                  40                  45            
 Asp Leu Thr Thr Leu Val Pro Glu Arg Gln Val Asp Gln Gly Arg Gly
      50                  55                  60                
 Phe Glu Ser Ile Leu Asp Val Leu Ser Val Met Tyr Ile Asn Ala Gln
  65                  70                  75                  80
 Leu Pro Arg Glu Gln Arg His Arg Trp Arg Leu Leu Phe Ser Ser Glu
                  85                  90                  95    
 Leu His Gly His Ser Phe Ser Gln Leu Cys Gly His Ile Thr His Arg
             100                 105                 110        
 Gly Pro Cys Val Ala Val Leu Glu Asp His Asp Lys His Val Phe Gly
         115                 120                 125            
 Gly Phe Ala Ser Cys Ser Trp Glu Val Lys Pro Gln Phe Gln Gly Asp
     130                 135                 140                
 Asn Arg Cys Phe Leu Phe Ser Ile Cys Pro Ser Met Ala Val Tyr Thr
 145                 150                 155                 160
 His Thr Gly Tyr Asn Asp His Tyr Met Tyr Leu Asn His Gly Gln Gln
                 165                 170                 175    
 Thr Ile Pro Asn Gly Leu Gly Met Gly Gly Gln His Asn Tyr Phe Gly
             180                 185                 190        
 Leu Trp Val Asp Val Asp Phe Gly Lys Gly His Ser Arg Ala Lys Pro
         195                 200                 205            
 Thr Cys Thr Thr Tyr Asn Ser Pro Gln Leu Ser Ala Gln Glu Asn Phe
     210                 215                 220                
 Gln Phe Asp Lys Met Glu Val Trp Ala Val Gly Asp Pro Ser Glu Glu
 225                 230                 235                 240
 Gln Leu Ala Lys Gly Asn Lys Ser Ile Leu Asp Ala Asp Pro Glu Ala
                 245                 250                 255    
 Gln Ala Leu Leu Glu Ile Ser Gly His Ser Arg His Ser Glu Gly Leu
             260                 265                 270        
 Arg Glu Val Pro Asp Asp Glu
         275                



      <210> 818
      <211> 131
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(131)
      <223> Xaa = any amino acid or nothing 


      <400> 818
 Gln Tyr Gly Leu Tyr Asn Gly Gly Gly Ala Ile Met Ala Ala Leu His
   1               5                  10                  15    
 Glu Ser Phe Thr Ser Cys Leu Asn Tyr Gly Gly Pro Gln Lys Phe Ser
              20                  25                  30        
 Pro Glu Gly Asp Leu Cys Ser Ser Pro Asp Pro Lys Ile Cys Tyr Val
          35                  40                  45            
 Cys Lys Lys Ser Phe Lys Ser Ser Tyr Ser Val Lys Leu His Tyr Arg
      50                  55                  60                
 Asn Val His Leu Lys Glu Met His Val Cys Thr Val Ala Gly Cys Asn
  65                  70                  75                  80
 Ala Ala Phe Pro Ser Arg Arg Ser Arg Asp Arg Lys Asp Xaa Lys Ala
                  85                  90                  95    
 Asp Leu Ile Val Thr Arg His Ser Ala Asn Ile Asn Leu His Arg Lys
             100                 105                 110        
 Leu Leu Thr Lys Glu Leu Asp Asp Met Gly Leu Asp Ser Ser Gln Pro
         115                 120                 125            
 Ser Leu Ser
     130    



      <210> 819
      <211> 97
      <212> PRT
      <213> Homo sapiens


      <400> 819
 Leu Trp Pro Ser Arg Pro Thr Thr Asp Pro Leu Gln Pro Arg Pro Ala
   1               5                  10                  15    
 Asp Pro Gly Leu Arg Arg Leu Pro Pro Asp Ser Pro Ser Pro Ser Arg
              20                  25                  30        
 Pro Ala Arg Pro Thr Leu Cys Pro Phe Ser Pro Ala Ala Arg Phe Pro
          35                  40                  45            
 Val Ala Pro Ser Ser Ala Leu Ala Ser Ser Glu Asp Leu Gln Pro Pro
      50                  55                  60                
 Ser Pro Ser Ser Ser Gly Ser Gly Leu Pro Gly Gln Ala Pro Pro Cys
  65                  70                  75                  80
 Tyr Ala Pro Thr Tyr Phe Pro Pro Gly Glu Glu Pro Pro Pro Tyr Ala
                  85                  90                  95    
 Pro
    



      <210> 820
      <211> 109
      <212> PRT
      <213> Homo sapiens


      <400> 820
 His Glu Val Arg Phe Phe Val Val Asp Cys Arg Pro Ala Glu Gln Tyr
   1               5                  10                  15    
 Gly Ala Gly His Leu Ser Thr Ala Phe His Leu Asp Ser Asp Leu Met
              20                  25                  30        
 Leu Gln Asn Pro Ser Glu Phe Ala Gln Ser Val Lys Ser Leu Leu Glu
          35                  40                  45            
 Ala Gln Lys Gln Ser Ile Glu Ser Gly Ser Ile Ala Gly Gly Glu His
      50                  55                  60                
 Leu Cys Phe Met Gly Ser Gly Arg Glu Glu Glu Asp Met Tyr Met Asn
  65                  70                  75                  80
 Met Val Leu Ala His Phe Leu Gln Lys Asn Thr Glu Tyr Val Ser Ile
                  85                  90                  95    
 Ala Ser Gly Gly Phe Met Ala Leu Gln Gln His Leu Ala
             100                 105                



      <210> 821
      <211> 155
      <212> PRT
      <213> Homo sapiens


      <400> 821
 Thr Val Leu Cys Ala Thr Gly Gly Gly Ala Tyr Lys Phe Glu Lys Asp
   1               5                  10                  15    
 Phe Arg Thr Ile Gly Asn Leu His Leu His Lys Leu Asp Glu Leu Asp
              20                  25                  30        
 Cys Leu Val Lys Gly Leu Leu Tyr Ile Asp Ser Val Ser Phe Asn Gly
          35                  40                  45            
 Gln Ala Glu Cys Tyr Tyr Phe Ala Asn Ala Ser Glu Pro Glu Arg Cys
      50                  55                  60                
 Gln Lys Met Pro Phe Asn Leu Asp Asp Pro Tyr Pro Leu Leu Val Val
  65                  70                  75                  80
 Asn Ile Gly Ser Gly Val Ser Ile Leu Ala Val His Ser Lys Asp Asn
                  85                  90                  95    
 Tyr Lys Arg Val Thr Gly Thr Ser Leu Gly Gly Gly Thr Phe Leu Gly
             100                 105                 110        
 Leu Cys Ser Leu Leu Thr Gly Cys Glu Ser Phe Glu Glu Ala Leu Glu
         115                 120                 125            
 Met Ala Ser Lys Gly Asp Ser Thr Gln Ala Asp Lys Leu Val Arg Asp
     130                 135                 140                
 Ile Tyr Gly Gly Asp Tyr Glu Arg Phe Gly Leu
 145                 150                 155



      <210> 822
      <211> 124
      <212> PRT
      <213> Homo sapiens


      <400> 822
 Trp Tyr Val Val Pro Pro Glu His Gly Gln Arg Leu Asp Arg Leu Ala
   1               5                  10                  15    
 Arg Glu Leu Phe Pro Gly Ser Ser Arg Cys Cys Gly Ala Phe Leu Arg
              20                  25                  30        
 His Lys Val Ala Leu Ile Ser Pro Thr Val Leu Lys Glu Asn Gly Ile
          35                  40                  45            
 Pro Phe Asn Arg Ile Thr Gln Glu Ala Gly Glu Phe Met Glu Thr Phe
      50                  55                  60                
 Pro Tyr Gly Tyr His Ala Gly Phe Asn His Gly Phe Asn Cys Ala Glu
  65                  70                  75                  80
 Ala Ile Asn Phe Ala Thr Pro Arg Trp Ile Asp Tyr Gly Lys Met Ala
                  85                  90                  95    
 Ser Gln Cys Ile Cys Gly Lys Ala Arg Val Thr Phe Ser Met Asp Ala
             100                 105                 110        
 Phe Val Arg Ile Leu Gln Pro Glu Arg Tyr Asp Leu
         115                 120                



      <210> 823
      <211> 105
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(105)
      <223> Xaa = any amino acid or nothing 


      <400> 823
 Met Met Gly Leu Arg Leu Gln Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
   1               5                  10                  15    
 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
              20                  25                  30        
 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
          35                  40                  45            
 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
      50                  55                  60                
 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
  65                  70                  75                  80
 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
                  85                  90                  95    
 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
             100                 105



      <210> 824
      <211> 92
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(92)
      <223> Xaa = any amino acid or nothing 


      <400> 824
 Asp Gly Pro Gly Cys Trp Gly Phe Arg Arg Arg Trp Pro Glu Ala Ser
   1               5                  10                  15    
 Trp Arg Asp Ser Ala Arg Trp His Gly Cys Arg Ser Pro Gly Gly Pro
              20                  25                  30        
 Gly Pro Ala Arg Pro Pro Cys Pro Ala Xaa Gly Gly Cys Ala Xaa Cys
          35                  40                  45            
 Gly Leu Thr Ala Arg Pro Pro Gln Thr Ala Tyr Tyr Thr Trp Cys Arg
      50                  55                  60                
 Thr Pro Pro Ala Trp Arg Ser Ala Thr Val Thr Arg Thr Pro Cys Xaa
  65                  70                  75                  80
 Gly Cys Pro Gly Pro Ala Gly Ala Pro Ser Ala Ala
                  85                  90        



      <210> 825
      <211> 134
      <212> PRT
      <213> Homo sapiens


      <400> 825
 Gly Pro Asp Ala Gly Trp Gly Asp Arg Ile Pro Leu Glu Ile Leu Val
   1               5                  10                  15    
 Gln Ile Phe Gly Leu Leu Val Ala Ala Asp Gly Pro Met Pro Phe Leu
              20                  25                  30        
 Gly Arg Ala Ala Arg Val Cys Arg Arg Trp Gln Glu Ala Ala Ser Gln
          35                  40                  45            
 Pro Ala Leu Trp His Thr Val Thr Leu Ser Ser Pro Leu Val Gly Arg
      50                  55                  60                
 Pro Ala Lys Gly Ser Val Lys Ala Glu Lys Lys Leu Leu Ala Ser Leu
  65                  70                  75                  80
 Glu Trp Leu Met Pro Asn Arg Phe Ser Gln Leu Gln Arg Leu Thr Leu
                  85                  90                  95    
 Ile His Trp Lys Ser Gln Leu Val Gly Glu Cys Cys Pro Arg Leu Thr
             100                 105                 110        
 Phe Leu Lys Leu Ser Gly Cys His Gly Val Thr Ala Asp Ala Leu Val
         115                 120                 125            
 Met Leu Ala Lys Ala Cys
     130                



      <210> 826
      <211> 79
      <212> PRT
      <213> Homo sapiens


      <400> 826
 Ser Val Ile Phe Val Phe Tyr Ser Met Phe Gln Asp Ala Cys Glu Leu
   1               5                  10                  15    
 Asp Val Ile Glu Ile Ser Leu Phe Val Asn Arg Cys Phe Ser Val Gln
              20                  25                  30        
 Leu Ile His Phe Leu Ile Cys Lys Leu Ile Pro His Gly Cys His Gln
          35                  40                  45            
 Leu Ser Gln Val Ile Phe Leu Asn Gly Ala Cys Cys Phe Phe Ile Lys
      50                  55                  60                
 Ala Ser Arg Ser Ile Ser Asp Asp Ile Phe Arg Ile Cys Ala Ile
  65                  70                  75                



      <210> 827
      <211> 119
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(119)
      <223> Xaa = any amino acid or nothing 


      <400> 827
 Ser Glu Arg Tyr Leu Ser Asn Pro Thr Pro Pro Val Pro Pro Xaa Ser
   1               5                  10                  15    
 Ala Val Tyr Leu Ser Asn Pro Thr Pro His Val Pro Pro Xaa Ser Asp
              20                  25                  30        
 Arg Tyr Leu Ser Asn Pro Ser Pro Pro Val Pro Pro Xaa Ser Asn Arg
          35                  40                  45            
 Tyr Leu Ser Asn Pro Thr Thr Pro Val Pro Arg Xaa Ser Asp Arg Tyr
      50                  55                  60                
 Met Tyr Asn Asn Thr Pro Pro Val Pro Pro Xaa Ser Glu Arg Tyr Leu
  65                  70                  75                  80
 Ser Asn Pro Thr Pro Pro Val Pro Pro Xaa Tyr Asp Arg Tyr Leu Ser
                  85                  90                  95    
 Asn Arg Thr Pro His Val Ser Pro Xaa Tyr Asp Arg Tyr Leu Ser Asn
             100                 105                 110        
 Pro Thr Pro Pro Val Ser Pro
         115                



      <210> 828
      <211> 144
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(144)
      <223> Xaa = any amino acid or nothing 


      <400> 828
 Val Thr Pro Glu Lys Gln His Glu Gln Trp Ile Pro His Ser Ser Ile
   1               5                  10                  15    
 Arg Gln Gln Asn Gln Gln Pro Lys Glu Gln Trp Ser Xaa Tyr Pro Ala
              20                  25                  30        
 Pro Gln Ser Gly Ser Pro Leu Thr Ile Met Glu Gly Thr Val Val Val
          35                  40                  45            
 Gln Gln Leu Met Ser Val Met Ile Ser Lys His Asp Cys Leu Phe Pro
      50                  55                  60                
 Lys Asp Ala Glu Leu Gln Ser Lys Pro Gln Asp Gly Val Ser Asn Asn
  65                  70                  75                  80
 Asn Glu Ile Gln Lys Lys Ala Thr Met Gly Gln Leu Gln Asn Lys Glu
                  85                  90                  95    
 Asn Asn Asn Thr Lys Asp Ser Pro Ser Arg Gln Cys Ser Trp Asp Lys
             100                 105                 110        
 Ser Glu Ser Pro Gln Arg Asn Ser Met Asn Asn Gly Ser Pro Thr Ala
         115                 120                 125            
 Leu Ser Gly Ser Lys Thr Asn Ser Pro Lys Asn Ser Gly His Lys Leu
     130                 135                 140                





      <210> 829
      <211> 485
      <212> PRT
      <213> Homo sapiens


      <400> 829
 Met Lys Glu Asn Phe Lys His Arg His Val Val Ala Phe Ile Ser Ser
   1               5                  10                  15    
 Gln Glu Ala Gln Glu Asp Ser Arg Glu Glu Glu Asp Arg Leu Glu Ser
              20                  25                  30        
 Arg Phe Tyr Phe Leu Phe Leu Leu Glu Leu Ser Tyr Lys Thr Thr Gly
          35                  40                  45            
 Leu Asn Arg Glu Pro Thr Val Ser Leu Asn Ser Lys Ser Gly Thr Pro
      50                  55                  60                
 Met Asp Gln Asn Glu His Ser His Trp Gly Pro His Ala Lys Gly Gln
  65                  70                  75                  80
 Cys Ala Ser Arg Ser Glu Leu Arg Ile Ile Leu Val Gly Lys Thr Gly
                  85                  90                  95    
 Thr Gly Lys Ser Ala Ala Gly Asn Ser Ile Leu Arg Lys Gln Ala Phe
             100                 105                 110        
 Glu Ser Lys Leu Gly Ser Gln Thr Leu Thr Lys Thr Cys Ser Lys Ser
         115                 120                 125            
 Gln Gly Ser Trp Gly Asn Arg Glu Ile Val Ile Ile Asp Thr Pro Asp
     130                 135                 140                
 Met Phe Ser Trp Lys Asp His Cys Glu Ala Leu Tyr Lys Glu Val Gln
 145                 150                 155                 160
 Arg Cys Tyr Leu Val Ala Gly Pro Lys Pro His Val Leu Leu Leu Val
                 165                 170                 175    
 Thr Gln Leu Gly Arg Tyr Thr Ser Gln Asp Gln Gln Ala Ala Gln Arg
             180                 185                 190        
 Val Lys Glu Ile Phe Gly Glu Asp Ala Met Gly His Thr Ile Val Leu
         195                 200                 205            
 Phe Thr His Lys Glu Asp Leu Asn Gly Gly Ser Leu Met Asp Tyr Met
     210                 215                 220                
 His Asp Ser Asp Asn Lys Ala Leu Ser Lys Leu Val Ala Ala Cys Gly
 225                 230                 235                 240
 Gly Arg Ile Cys Ala Phe Asn Asn Arg Ala Glu Gly Ser Asn His Asp
                 245                 250                 255    
 Asp Gln Val Lys Glu Leu Met Asp Cys Ile Glu Asp Leu Leu Met Glu
             260                 265                 270        
 Lys Asn Gly Asp His Tyr Thr Asn Gly Leu Tyr Ser Leu Ile Gln Arg
         275                 280                 285            
 Ser Lys Cys Gly Pro Val Gly Ser Asp Glu Arg Val Lys Glu Phe Lys
     290                 295                 300                
 Gln Ser Leu Ile Lys Tyr Met Glu Thr Gln Arg Ser Tyr Thr Ala Leu
 305                 310                 315                 320
 Ala Glu Ala Asn Cys Leu Lys Gly Ala Leu Ile Lys Thr Gln Leu Pro
                 325                 330                 335    
 Lys Val Asp Lys Thr Thr Lys Ile Gly Lys Lys Gln Ser Arg Lys Thr
             340                 345                 350        
 Gly Asn Ser Lys Lys Gln Ser Thr Ser Pro Pro Pro Lys Glu Arg Ser
         355                 360                 365            
 Ser Ser Pro Ala Met Glu Gln Ser Trp Thr Glu Asn Asp Phe Asp Glu
     370                 375                 380                
 Leu Arg Glu Glu Gly Phe Arg Arg Ser His Tyr Ser Glu Leu Pro Glu
 385                 390                 395                 400
 Asp Ile Gln Thr Glu Gly Arg Glu Val Glu Asn Phe Glu Lys Ser Leu
                 405                 410                 415    
 Glu Glu Cys Ile Thr Arg Ile Thr His Thr Glu Lys Cys Leu Lys Glu
             420                 425                 430        
 Leu Met Glu Leu Lys Thr Lys Ala Arg Glu Leu Arg Glu Glu Cys Arg
         435                 440                 445            
 Ser Leu Arg Ser Gln Cys Asp Gln Leu Glu Glu Arg Val Ser Ala Met
     450                 455                 460                
 Glu Asp Glu Met Asn Glu Met Lys Arg Glu Gly Lys Phe Lys Glu Lys
 465                 470                 475                 480
 Lys Asn Lys Lys Lys
                 485



      <210> 830
      <211> 384
      <212> PRT
      <213> Homo sapiens


      <400> 830
 Ala Pro Pro Val Pro Ala Asn Ala Leu Gly Ala Arg Gly Glu Ala Val
   1               5                  10                  15    
 Arg Leu Gln Leu Gln Gly Glu Glu Leu Arg Leu Gln Glu Glu Ser Val
              20                  25                  30        
 Arg Leu His Gln Ile Asn Ile Tyr Leu Ser Asp Arg Ile Ser Leu His
          35                  40                  45            
 Arg Arg Leu Pro Val Arg Trp Asn Pro Leu Cys Lys Glu Lys Lys Tyr
      50                  55                  60                
 Asp Tyr Asp Asn Leu Pro Arg Thr Ser Val Ile Ile Ala Phe Tyr Asn
  65                  70                  75                  80
 Glu Ala Trp Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Leu Glu Thr
                  85                  90                  95    
 Ser Pro Asp Ile Leu Leu Glu Glu Val Ile Leu Val Asp Asp Tyr Ser
             100                 105                 110        
 Asp Arg Glu His Leu Lys Glu Arg Leu Ala Asn Glu Leu Ser Gly Leu
         115                 120                 125            
 Pro Lys Val Arg Leu Ile Arg Ala Asn Lys Arg Glu Gly Leu Val Arg
     130                 135                 140                
 Ala Arg Leu Leu Gly Ala Ser Ala Ala Arg Gly Asp Val Leu Thr Phe
 145                 150                 155                 160
 Leu Asp Cys His Cys Glu Cys His Glu Gly Trp Leu Glu Pro Leu Leu
                 165                 170                 175    
 Gln Arg Ile His Glu Glu Glu Ser Ala Val Val Cys Pro Val Thr Asp
             180                 185                 190        
 Val Ile Asp Trp Asn Thr Phe Glu Tyr Leu Gly Asn Ser Gly Glu Pro
         195                 200                 205            
 Gln Ile Gly Gly Phe Asp Trp Arg Leu Val Phe Arg Trp His Thr Val
     210                 215                 220                
 Pro Glu Arg Glu Arg Ile Arg Met Gln Ser Pro Val Asp Val Ile Arg
 225                 230                 235                 240
 Ser Pro Thr Met Ala Gly Gly Leu Phe Ala Val Ser Lys Lys Tyr Phe
                 245                 250                 255    
 Glu Tyr Leu Gly Ser Tyr Asp Thr Gly Met Glu Val Trp Gly Gly Glu
             260                 265                 270        
 Asn Leu Glu Phe Ser Phe Arg Ile Trp Gln Cys Gly Gly Val Leu Glu
         275                 280                 285            
 Thr His Pro Cys Ser His Val Gly His Val Phe Pro Lys Gln Ala Pro
     290                 295                 300                
 Tyr Ser Arg Asn Lys Ala Leu Ala Asn Ser Val Arg Ala Ala Glu Val
 305                 310                 315                 320
 Trp Met Asp Glu Phe Lys Glu Leu Tyr Tyr His Arg Asn Pro Arg Ala
                 325                 330                 335    
 Arg Leu Glu Pro Phe Gly Asp Val Thr Glu Arg Lys Gln Leu Arg Asp
             340                 345                 350        
 Lys Leu Gln Cys Lys Asp Phe Lys Trp Phe Leu Glu Thr Val Tyr Pro
         355                 360                 365            
 Glu Leu His Val Pro Glu Asp Arg Pro Gly Phe Phe Gly Met Leu Gln
     370                 375                 380                





      <210> 831
      <211> 24
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(24)
      <223> Xaa = any amino acid or nothing 


      <400> 831
 Xaa Phe Cys Phe Leu Leu Ala Asp Met Ile Met Gln Ser Gly Asp Ala
   1               5                  10                  15    
 Ile Ser Gly Phe Pro Val Cys Leu
              20                



      <210> 832
      <211> 591
      <212> PRT
      <213> Homo sapiens


      <400> 832
 Met Pro Val Leu Pro Val Thr Ala Thr Glu Ile Arg Gln Tyr Leu Arg
   1               5                  10                  15    
 Gly His Gly Ile Pro Phe Gln Asp Gly His Ser Cys Leu Arg Ala Leu
              20                  25                  30        
 Ser Pro Phe Ala Glu Ser Ser Gln Leu Lys Gly Gln Thr Gly Val Thr
          35                  40                  45            
 Thr Ser Phe Ser Leu Phe Ile Asp Lys Thr Thr Gly His Phe Leu Cys
      50                  55                  60                
 Met Thr Ser Leu Ala Glu Gly Ser Trp Glu Asp Phe Gln Ala Ser Val
  65                  70                  75                  80
 Glu Gly Arg Gly Asp Gly Ala Arg Glu Gly Phe Leu Leu Ser Lys Ala
                  85                  90                  95    
 Pro Glu Phe Glu Asp Ser Glu Glu Val Arg Arg Ile Trp Asn Arg Ala
             100                 105                 110        
 Ile Pro Leu Trp Glu Leu Pro Asp Gln Glu Glu Val Gln Leu Ala Asp
         115                 120                 125            
 Thr Met Phe Gly Leu Thr Lys Val Thr Asp Asp Thr Leu Lys Arg Phe
     130                 135                 140                
 Ser Val Arg Tyr Leu Arg Pro Ala Arg Ser Leu Val Phe Pro Trp Phe
 145                 150                 155                 160
 Ser Pro Gly Gly Ser Gly Leu Arg Gly Leu Lys Leu Leu Glu Ala Lys
                 165                 170                 175    
 Cys Gln Gly Asp Gly Val Ser Tyr Glu Glu Thr Thr Ile Pro Arg Pro
             180                 185                 190        
 Ser Ala Tyr His Asn Leu Phe Gly Leu Pro Leu Ile Ser Arg Arg Asp
         195                 200                 205            
 Ala Glu Val Val Leu Thr Ser Arg Glu Leu Asp Ser Leu Ala Leu Asn
     210                 215                 220                
 Gln Ser Thr Gly Leu Pro Thr Leu Thr Leu Pro Arg Gly Thr Thr Cys
 225                 230                 235                 240
 Leu Pro Pro Ala Leu Leu Pro Tyr Leu Glu Gln Phe Arg Arg Ile Val
                 245                 250                 255    
 Phe Trp Leu Gly Asp Asp Leu Arg Ser Trp Glu Ala Ala Lys Leu Phe
             260                 265                 270        
 Ala Arg Lys Leu Asn Pro Lys Arg Cys Phe Leu Val Arg Pro Gly Asp
         275                 280                 285            
 Gln Gln Pro Arg Pro Leu Glu Ala Leu Asn Gly Gly Phe Asn Leu Ser
     290                 295                 300                
 Arg Ile Leu Arg Thr Ala Leu Pro Ala Trp His Lys Ser Ile Val Ser
 305                 310                 315                 320
 Phe Arg Gln Leu Arg Glu Glu Val Leu Gly Glu Leu Ser Asn Val Glu
                 325                 330                 335    
 Gln Ala Ala Gly Leu Arg Trp Ser Arg Phe Pro Asp Leu Asn Arg Ile
             340                 345                 350        
 Leu Lys Gly His Arg Lys Gly Glu Leu Thr Val Phe Thr Gly Pro Thr
         355                 360                 365            
 Gly Ser Gly Lys Thr Thr Phe Ile Ser Glu Tyr Ala Leu Asp Leu Cys
     370                 375                 380                
 Ser Gln Gly Val Asn Thr Leu Trp Gly Ser Phe Glu Ile Ser Asn Val
 385                 390                 395                 400
 Arg Leu Ala Arg Val Met Leu Thr Gln Phe Ala Glu Gly Arg Leu Glu
                 405                 410                 415    
 Asp Gln Leu Asp Lys Tyr Asp His Trp Ala Asp Arg Phe Glu Asp Leu
             420                 425                 430        
 Pro Leu Tyr Phe Met Thr Phe His Gly Gln Gln Asn Ile Arg Thr Val
         435                 440                 445            
 Ile Gly Thr Met Asn His Ala Val Tyr Val Tyr Asp Ile Cys His Val
     450                 455                 460                
 Ile Ile Asp Asn Leu Gln Phe Met Met Gly His Glu Gln Leu Ser Thr
 465                 470                 475                 480
 Asp Arg Ile Ala Ala Gln Asp Tyr Ile Ile Gly Val Phe Arg Lys Phe
                 485                 490                 495    
 Ala Thr Asp Asn Asn Cys His Val Thr Leu Val Ile His Pro Arg Lys
             500                 505                 510        
 Glu Asp Asp Asp Lys Glu Leu Gln Thr Ala Ser Ile Phe Gly Ser Ala
         515                 520                 525            
 Lys Gly Gly Glu Trp Ser Ala Pro His Ser Thr Ser Ser Arg Pro Ser
     530                 535                 540                
 Ala Gln Pro Lys Ser Asp Ser Thr Val Ala Glu Ala Ala Pro Leu Ala
 545                 550                 555                 560
 Ser Asp Phe Thr Ala Tyr Trp Ile Trp Phe Leu Thr Trp Gly Arg Gly
                 565                 570                 575    
 Arg Ala Ser Arg Asp Arg Glu Phe Gly Tyr Leu Ala Ala Leu Asn
             580                 585                 590    



      <210> 833
      <211> 152
      <212> PRT
      <213> Homo sapiens


      <400> 833
 Ala Asp Arg Pro Trp His Glu Pro Gly Ala Gly Cys Ala Ala Asp Cys
   1               5                  10                  15    
 Glu Asp Pro His Arg Arg Pro Gly Ala Cys Glu Pro Gly Ala Pro Pro
              20                  25                  30        
 Ala Ala Arg Ala Ala Gly Leu Gly Arg Gly Thr Arg His Gly Asn Gly
          35                  40                  45            
 Asp Ile Leu Ser Phe Glu Asp Ala Asn Arg Ala Met Gln Thr Gly Val
      50                  55                  60                
 Thr Gly Ile Met Ile Ala Arg Gly Ala Leu Leu Lys Pro Trp Leu Phe
  65                  70                  75                  80
 Thr Glu Ile Lys Glu Gln Arg His Trp Asp Ile Ser Ser Ser Glu Arg
                  85                  90                  95    
 Leu Asp Ile Leu Arg Asp Phe Thr Asn Tyr Gly Leu Glu His Trp Gly
             100                 105                 110        
 Ser Asp Thr Gln Gly Val Glu Lys Thr Arg Arg Phe Leu Leu Glu Trp
         115                 120                 125            
 Leu Ser Phe Leu Cys Arg Tyr Val Pro Val Gly Leu Leu Glu Arg Leu
     130                 135                 140                
 Pro Gln Arg Ile Asn Glu Arg Pro
 145                 150        



      <210> 834
      <211> 113
      <212> PRT
      <213> Homo sapiens


      <400> 834
 Thr Gly Met Asp Tyr Leu Gln Val Gly Val Thr Ser Gln Lys Thr Met
   1               5                  10                  15    
 Lys Leu Ile Pro Ala Ser Arg His Arg Ala Thr Gln Lys Val Val Ile
              20                  25                  30        
 Gly Asp His Asp Gly Val Val Met Cys Phe Gly Met Lys Lys Gly Glu
          35                  40                  45            
 Ala Ala Ala Val Phe Lys Thr Leu Pro Gly Pro Lys Ile Ala Arg Leu
      50                  55                  60                
 Glu Leu Gly Gly Val Ile Asn Thr Pro Gln Glu Lys Ile Phe Ile Ala
  65                  70                  75                  80
 Ala Ala Ser Glu Ile Arg Gly Phe Thr Lys Lys Gly Lys Gln Phe Leu
                  85                  90                  95    
 Ser Phe Glu Thr Asn Leu Thr Glu Ser Ile Lys Ala Met Tyr Val Lys
             100                 105                 110        
 Cys
    



      <210> 835
      <211> 74
      <212> PRT
      <213> Homo sapiens


      <400> 835
 Thr Met Gly Leu Glu Lys Pro Gln Ser Lys Leu Glu Gly Gly Met His
   1               5                  10                  15    
 Pro Gln Leu Ile Pro Ser Val Ile Ala Val Val Phe Ile Leu Leu Leu
              20                  25                  30        
 Gly Val Cys Phe Ile Ala Ser Cys Leu Val Thr His His Asn Phe Ser
          35                  40                  45            
 Arg Trp Lys Arg Gly Thr Gly Val His Lys Leu Lys His His Ala Lys
      50                  55                  60                
 Leu Lys Cys Ile Lys Glu Lys Ser Glu Leu
  65                  70                



      <210> 836
      <211> 41
      <212> PRT
      <213> Homo sapiens


      <400> 836
 Gly Arg Phe Leu Ser Leu Ser His Phe Cys Pro Pro Ala Pro Thr Ser
   1               5                  10                  15    
 Gln Val Arg Pro Trp Ala Leu Glu Leu Arg Asp Ser Pro His Pro Ser
              20                  25                  30        
 Pro Thr Pro Ala Pro Ser Leu Met Leu
          35                  40    



      <210> 837
      <211> 140
      <212> PRT
      <213> Homo sapiens


      <400> 837
 Asn Trp Ala Gly Ala Gln Arg Leu Thr Met Thr His Gly Ser Cys Leu
   1               5                  10                  15    
 Pro Gln Leu Ser Asp Lys Val Ala Pro Ala Lys His Trp Arg Pro Lys
              20                  25                  30        
 Pro Arg Ser Ile Thr Pro Ile Val Thr Pro Pro Ile Ser Ser Ala Ser
          35                  40                  45            
 Ala Val Lys Gly Lys Arg Glu Lys Gly Ser Glu Ala Leu Val Pro Pro
      50                  55                  60                
 His Leu Val Gly Arg Tyr Ala Ser Ser Arg Ser His Pro Ser Gln Gly
  65                  70                  75                  80
 Gly Glu Gly Arg Pro Gln Ala Gly Cys Gly His Ser Trp Leu Thr Leu
                  85                  90                  95    
 Ser Ser Ala Thr Asp Arg Leu Ser His Ser Trp Ala Gly Leu Asn Pro
             100                 105                 110        
 Arg Cys Pro Pro Ala Ala Thr Trp Pro Pro Cys Ser Thr Phe Ser Pro
         115                 120                 125            
 Phe Ala Ser Ser Gly Cys Arg Gln Pro Ser Ser Phe
     130                 135                 140



      <210> 838
      <211> 130
      <212> PRT
      <213> Homo sapiens


      <400> 838
 Gln Leu Met Gly Ala Asp Leu Cys Arg Ile Lys Met Lys Lys His Leu
   1               5                  10                  15    
 Thr Thr Phe Leu Val Ile Leu Trp Leu Tyr Phe Tyr Arg Gly Asn Gly
              20                  25                  30        
 Arg Tyr Gln Pro Glu Leu Ser Pro Gln Pro Leu Ile Ile Leu Glu Gly
          35                  40                  45            
 Lys Asn Cys Ser Leu Arg Cys Ile Tyr Thr Ala Ser Pro Phe Thr Ser
      50                  55                  60                
 Leu Trp Arg Tyr Asn His Asp Thr Gly Arg Gly Pro Val Ser Leu Thr
  65                  70                  75                  80
 Ile Met Thr Phe Ser Glu Asn Thr Lys Pro Asn Gly Arg Tyr Thr Ala
                  85                  90                  95    
 Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Tyr
             100                 105                 110        
 Gln Leu Ile Asp Ser Ala Ser Tyr Ile Cys Val Val Ser Ala Leu Cys
         115                 120                 125            
 Ser Thr
     130



      <210> 839
      <211> 76
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(76)
      <223> Xaa = any amino acid or nothing 


      <400> 839
 His Pro Val Lys His Ile Ile Arg Pro Pro Lys His Thr Ser Gly Lys
   1               5                  10                  15    
 Lys Pro Asn Lys Arg Val Thr Arg Lys Asn Ser Ile Phe Met Asp Glu
              20                  25                  30        
 Val Xaa Pro Arg Lys Ile Glu Val Glu Phe Gln Glu Glu Val Val Ile
          35                  40                  45            
 Arg Gly Met Met Pro Trp Ser Thr Ser Cys Ser Leu Val Leu Leu Cys
      50                  55                  60                
 Cys Ser Leu Ser Trp Ser Thr Gln Ile Val Asn Phe
  65                  70                  75    



      <210> 840
      <211> 82
      <212> PRT
      <213> Homo sapiens


      <400> 840
 Met Thr Leu Gly Ile Thr Ser Phe Ile Ser Phe Tyr Phe Cys Phe Ile
   1               5                  10                  15    
 Ile Tyr Ile Phe Gln Tyr Leu Ile Ile Gly Lys Lys Asn Leu Thr Phe
              20                  25                  30        
 Ser Val Leu Lys Phe Phe Ile Ile Lys Tyr Ile Ser Leu Ile Ile Ile
          35                  40                  45            
 Ser Lys Glu Glu Lys Asn Thr Phe Lys Ile Ser His Trp Ile Trp Lys
      50                  55                  60                
 Ile Ile Ile Met Glu Leu Trp Phe Leu Met Ser Thr His Ile Ser Phe
  65                  70                  75                  80
 Arg Tyr
        



      <210> 841
      <211> 306
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(306)
      <223> Xaa = any amino acid or nothing 


      <400> 841
 Pro Thr Pro His Arg Gly Ala Phe Gly Arg Leu Pro Glu Pro Gly Leu
   1               5                  10                  15    
 Val Gln Pro Gln Leu Pro Val Gly Pro Ala Pro Gly Leu Gly Gly Pro
              20                  25                  30        
 Gln Arg Ser Thr His Pro Pro Asp Gly Pro Ala Pro Gln Gly Gly Pro
          35                  40                  45            
 Val Pro Ala Ala Gly Ala His Pro Gln Thr His Leu His His Leu Arg
      50                  55                  60                
 Gly Pro Glu Ala Arg Pro Arg Arg Pro Gly Gly Pro Pro Ala Ala Pro
  65                  70                  75                  80
 Gln Arg Ala Thr Trp Xaa Pro Cys Cys Ser Gly Gly Pro Ala Pro Xaa
                  85                  90                  95    
 Leu Leu Pro Pro Ile Phe Gly Lys Lys Cys Ser Trp Arg Cys Arg Gly
             100                 105                 110        
 Lys Val Gln Tyr Arg Pro Val Glu Gly Asp Pro Gln Thr Gln Leu Gln
         115                 120                 125            
 Asp Asp Lys Asp Pro Met Leu Ile Leu Arg Gly Pro Ser Pro Xaa Gly
     130                 135                 140                
 Pro Gly Pro Gly Thr Ser Glu Val Asp Pro Asp Pro Xaa Arg Arg Thr
 145                 150                 155                 160
 Trp Val Ser Gly Gly Leu Phe Leu Glu Ser His Gln Ala Pro Pro Pro
                 165                 170                 175    
 Pro Gly Gly Leu Ala Gly Arg Glu Pro Glu Gln Arg Ser Gly Arg Leu
             180                 185                 190        
 Gly Ser Arg Pro Arg Glu Thr Thr Val Pro Arg Thr Asp Phe Tyr Leu
         195                 200                 205            
 Pro Trp Cys Gln Arg Met Asn Met Xaa Leu Pro Pro Gln Ser Gly Arg
     210                 215                 220                
 Ile Ile Gly Thr Ala Gly Ala Arg Ala Ala Ala Ser Leu Leu Cys Ser
 225                 230                 235                 240
 Thr Gly Pro Gln Pro Leu Pro Ala Ala Leu Gly Pro Cys Gln Gln Pro
                 245                 250                 255    
 Trp Asp Pro Ala Ser Ser Pro Gly Lys Arg Leu Trp Pro Gln Gly Pro
             260                 265                 270        
 Pro Ser Ala Arg Lys Xaa Ser Pro Gly Lys Arg Leu Trp Pro Gln Gly
         275                 280                 285            
 Ala Ser Gln Cys Gln Lys Ile Lys Ser Phe Trp Ile Leu Lys Lys Lys
     290                 295                 300                
 Lys Lys
 305    



      <210> 842
      <211> 189
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(189)
      <223> Xaa = any amino acid or nothing 


      <400> 842
 Leu Lys Ile Leu Ser Lys Met Lys Ile His Gln Gly Gly Tyr Asn Ser
   1               5                  10                  15    
 Asp Glu Asn Ala Cys Val His Gln His Arg Val Arg Ala Leu Thr Gly
              20                  25                  30        
 Ser Met Cys Lys Ser Lys Pro Gly Ser Pro Ala Pro Gly Gly Arg Xaa
          35                  40                  45            
 Asn Leu Pro Ser Arg Glu Pro Gly Ala Pro Ala Gly Ile Gly Gly Ser
      50                  55                  60                
 Phe Leu Ala Ser Ala Ala Val Ser Pro Ser Pro Pro Ser Pro His Xaa
  65                  70                  75                  80
 Cys Pro Leu Glu Xaa Glu Pro Val Ala Glu Ala Glu Gly Leu Leu Gly
                  85                  90                  95    
 Glu Leu Ser Lys Val Trp Lys Glu Gly Pro Pro Glu Arg Ala Pro Gly
             100                 105                 110        
 Xaa Pro Pro Arg Gly Pro Pro Gly Leu His Gln Leu His Ala Ser Gln
         115                 120                 125            
 Met Leu Phe Ile Gly Arg Pro Gly Gly Pro Gly Gln Ile Ser Pro Ala
     130                 135                 140                
 Pro Gly Cys Gly Gly Leu Glu Gly Cys Leu Ser Arg His Cys Ala Ile
 145                 150                 155                 160
 Ala Gly Ala Gly Glu Arg Ile Ser Glu Thr Thr Phe Gly Ser Asn Ala
                 165                 170                 175    
 Leu Tyr His Arg Ser Pro Asn Arg Leu Gly Gln Gly Leu
             180                 185                



      <210> 843
      <211> 170
      <212> PRT
      <213> Homo sapiens


      <400> 843
 Met Glu Val Ala Val Ser Arg Ile Met Thr Leu His Ser Ser Leu Gly
   1               5                  10                  15    
 Asp Arg Ala Arg Leu His Leu Lys Lys Lys Lys Glu Glu Glu Glu Lys
              20                  25                  30        
 Glu Glu Glu Glu Glu Glu Glu Glu Glu Lys Lys Lys Glu Glu Lys Glu
          35                  40                  45            
 Lys Glu Lys Lys Lys Glu Lys Met Met Arg Arg Arg Lys Lys Thr Lys
      50                  55                  60                
 Asn Asn Thr Lys Gln Asn Lys Thr Cys Ser Lys Gln Gln Ala Leu Leu
  65                  70                  75                  80
 Arg Lys Glu Lys Asn Phe His Lys Lys Arg Trp Pro Ala Ala Pro Gly
                  85                  90                  95    
 Val Thr Ala Arg Tyr Ala Thr Ser Lys Gly Asp Val Ser Ala Ala Ala
             100                 105                 110        
 Ser Thr Leu Pro Val Lys Thr Pro Ala Pro Ile Gln Arg Arg Gly Glu
         115                 120                 125            
 Val Ser Thr Ile His Leu Ser Gln Val Val Gln Trp Gln Trp Gly Pro
     130                 135                 140                
 His Ala Leu Tyr Thr Val Val Val Leu Leu Glu Glu Gly Glu Gln Leu
 145                 150                 155                 160
 Ser Pro Gly Asp Leu Gly Thr Gly Phe Ile
                 165                 170



      <210> 844
      <211> 213
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(213)
      <223> Xaa = any amino acid or nothing 


      <400> 844
 Val Gln Pro Leu Gly Asp Ala Gly Met Pro Xaa Asp Gly Gln Arg Ala
   1               5                  10                  15    
 Ala Pro Arg Ser Pro Ala Leu Gly Ala Arg Ala Leu Ala Gln Gly Ser
              20                  25                  30        
 Thr Gly Ala Thr Ala Gly Ala Ser Arg Lys Gln Glu Val Ala Ala Gly
          35                  40                  45            
 Pro Ala Gly His Arg Leu Val Ser Thr Ala Ala Ala Gly Gly Gly Pro
      50                  55                  60                
 Ser Leu Arg Gln Val Cys Ser Ala Gly Pro Pro Gly Arg Ala Val Arg
  65                  70                  75                  80
 Ser Gly Gly Arg Gly Gln Val Arg Glu Thr Pro Pro Gly Cys Leu Gly
                  85                  90                  95    
 Gly Ala Trp His Pro Arg Glu Pro Asn Gly His Ser Ala Phe Arg Phe
             100                 105                 110        
 Arg Pro Ala Gly Pro Ile Gly Val Leu Gly Pro Gln Pro Gly Pro Pro
         115                 120                 125            
 Gly Lys Xaa Pro Cys Thr Lys Ala Phe Pro Pro Leu Pro Pro Asn Ala
     130                 135                 140                
 Thr Ala Lys Ala Gly Pro Pro Pro Arg Cys Phe Pro Cys Gln Pro Cys
 145                 150                 155                 160
 Leu Ile Leu Gly Pro Pro Ser Pro Pro Gly Thr Leu Glu Gly Pro Ile
                 165                 170                 175    
 Pro Leu Ser Glu Thr Leu Pro Thr Pro His Ser Ser Ala Leu Gly Ala
             180                 185                 190        
 Ile Phe Ala Gln Gly Gly Gly Asp Gly Gly Ala Gly Ala Thr Glu Pro
         195                 200                 205            
 Ala His Leu Asn Leu
     210            



      <210> 845
      <211> 164
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(164)
      <223> Xaa = any amino acid or nothing 


      <400> 845
 Gly Leu Phe Gln Lys Pro Gly Gly Thr His Val Leu Pro Pro Ala Pro
   1               5                  10                  15    
 Lys Ala Val Gln Ala Ser Thr Asp Pro Pro Leu Lys Gly Gly Ser Pro
              20                  25                  30        
 Leu Leu Gln Gly Pro Trp Arg Arg Gly Arg Val Gly Cys Arg Gly Ala
          35                  40                  45            
 Gln Lys Gly Gly Pro Gly Asp Arg Gly Ser Ser Leu Leu Phe Lys Pro
      50                  55                  60                
 Gly Asp Gln Gly Gly Pro Ser Leu Thr Ser Gly Gln His Ser Lys Ser
  65                  70                  75                  80
 Glu Ala Gly Val Trp Gln Gly Leu Ser Trp Ser Pro Leu Gly Cys Gly
                  85                  90                  95    
 Phe Leu Pro Glu Pro His Gln Arg Pro Leu Glu Pro Arg Glu Gly Pro
             100                 105                 110        
 Arg Arg Ala Gly Val Thr Pro Gly Leu Glu His Ser Ser Gln Ser Pro
         115                 120                 125            
 Glu Ala Pro Gly Asp Arg Asn Lys Xaa Gln Ser Glu Thr Thr Arg Glu
     130                 135                 140                
 Lys Glu Ser Thr Val Ser Thr Lys Ser Pro Thr Leu Pro Lys His Pro
 145                 150                 155                 160
 Gly Gln Leu Gly
                



      <210> 846
      <211> 158
      <212> PRT
      <213> Homo sapiens


      <400> 846
 Ile Lys Met Ser Gly Lys Ala Asn Ala Ser Lys Lys Asn Ala Gln Gln
   1               5                  10                  15    
 Leu Lys Arg Asn Pro Lys Arg Lys Lys Asp Asn Glu Glu Val Val Leu
              20                  25                  30        
 Ser Glu Asn Lys Val Arg Asn Thr Val Lys Lys Asn Lys Asn His Leu
          35                  40                  45            
 Lys Asp Leu Ser Ser Glu Gly Gln Thr Lys His Thr Asn Leu Lys His
      50                  55                  60                
 Gly Lys Thr Ala Ala Ser Lys Arg Lys Thr Trp Gln Pro Leu Ser Lys
  65                  70                  75                  80
 Ser Thr Arg Asp His Leu Gln Thr Met Met Glu Ser Val Ile Met Thr
                  85                  90                  95    
 Ile Leu Ser Asn Ser Ile Lys Glu Lys Glu Glu Ile Gln Tyr His Leu
             100                 105                 110        
 Asn Phe Leu Lys Lys Arg Leu Leu Gln Gln Cys Glu Thr Leu Lys Val
         115                 120                 125            
 Pro Pro Lys Lys Met Glu Asp Leu Thr Asn Val Ser Ser Leu Leu Asn
     130                 135                 140                
 Met Glu Arg Ala Arg Asp Lys Ala Asn Glu Glu Gly Leu Ala
 145                 150                 155            



      <210> 847
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 847
 Ser Pro Arg Thr Gly Gly Gly Gly Gly Phe Gln Ser Pro Ala Pro Ala
   1               5                  10                  15    
 Gly Glu Arg Thr Met His Cys Leu Gly Ala Glu Tyr Leu Val Ser Ala
              20                  25                  30        
 Glu Gly Ala Pro Arg Gln Arg Glu Trp Arg Pro Gln Ile Tyr Arg Lys
          35                  40                  45            
 Cys Thr Asp Thr Ala Trp Leu Phe Leu Phe Phe Leu Phe Trp Thr Gly
      50                  55                  60                
 Leu Val Phe Ile Met Gly Tyr Ser Val Val Ala Gly Ala Ala Gly Arg
  65                  70                  75                  80
 Leu Leu Phe Gly Tyr Asp Ser Phe Gly Asn Met Cys Gly Lys Lys Asn
                  85                  90                  95    
 Ser Pro Val Glu Gly Ala Pro Leu Ser Gly Gln Asp Met Thr Leu Lys
             100                 105                 110        
 Lys His Val Phe Phe Met Asn Ser Cys Asn Leu Glu Val Lys Gly Thr
         115                 120                 125            
 Gln Leu Asn Arg Met
     130            



      <210> 848
      <211> 118
      <212> PRT
      <213> Homo sapiens


      <400> 848
 Met Ala Phe Leu Trp Leu Val Cys Cys Phe Ala Leu Val Gly Ala Thr
   1               5                  10                  15    
 Phe Gly Cys Gly Val Pro Ala Ile Gln Pro Gly Leu Thr Gly Leu Ser
              20                  25                  30        
 Arg Ile Val Asn Gly Glu Asp Ala Ile Pro Gly Ser Trp Pro Trp Gln
          35                  40                  45            
 Glu Ser Leu Gln Asp Arg Thr Gly Phe His Phe Cys Gly Gly Ser Leu
      50                  55                  60                
 Ile Ser Glu Asn Trp Val Val Thr Ala Ala His Cys Gly Val Lys Thr
  65                  70                  75                  80
 Thr Asp Val Val Val Ala Gly Glu Phe Asp Gln Gly Ser Asp Glu Lys
                  85                  90                  95    
 Asn Val Gln Val Leu Lys Ile Val Gln Val Phe Lys Asn Pro Lys Phe
             100                 105                 110        
 Asn Ser Phe Thr Val Arg
         115            



      <210> 849
      <211> 152
      <212> PRT
      <213> Homo sapiens


      <400> 849
 Pro Gly Arg Pro Thr Arg Pro Thr Ser Pro Ser Asn Thr Pro Ala Ser
   1               5                  10                  15    
 Ile Ser Pro Lys Leu Asn Val Glu Val Lys Lys Glu Val Asp Lys Glu
              20                  25                  30        
 Lys Ala Val Thr Asp Glu Lys Pro Lys Gln Lys Asp Lys Pro Gly Glu
          35                  40                  45            
 Glu Glu Glu Lys Cys Asp Ile Ser Ser Lys Tyr His Tyr Leu Thr Glu
      50                  55                  60                
 Asn Asp Leu Glu Glu Ser Pro Lys Gly Gly Leu Asp Ile Leu Lys Ser
  65                  70                  75                  80
 Leu Glu Asn Thr Val Thr Ser Ala Ile Asn Lys Ala Gln Asn Gly Thr
                  85                  90                  95    
 Pro Ser Trp Gly Gly Tyr Pro Ser Ile His Ala Ala Tyr Gln Leu Pro
             100                 105                 110        
 Asn Met Met Lys Leu Ser Leu Gly Ser Ser Gly Lys Ser Thr Pro Leu
         115                 120                 125            
 Lys Pro Met Phe Gly Asn Ser Glu Ile Val Ser Pro Thr Lys Asn Gln
     130                 135                 140                
 Thr Leu Val Ser Pro Pro Ser Ser
 145                 150        



      <210> 850
      <211> 98
      <212> PRT
      <213> Homo sapiens


      <400> 850
 Leu Gln Val Glu Ile Tyr Lys Thr Val Lys Met His Cys Ile Trp His
   1               5                  10                  15    
 Lys Gln Met Val Ser Ser Tyr Phe Phe Tyr Gln Lys Lys Asn Glu Leu
              20                  25                  30        
 Ser Asn Phe Glu Glu Val Phe Leu Lys Thr Ala Ser Gly Met Phe Phe
          35                  40                  45            
 Ser Thr Val Gly Cys His Pro Thr Arg Cys Gly Glu Phe Glu Lys Asn
      50                  55                  60                
 Asn Pro Asp Leu Tyr Leu Lys Glu Leu Leu Asn Leu Ala Glu Asn Asn
  65                  70                  75                  80
 Lys Gly Lys Val Val Ala Ile Gly Glu Cys Gly Leu Asp Phe Asp Arg
                  85                  90                  95    
 Leu Gln
        



      <210> 851
      <211> 156
      <212> PRT
      <213> Homo sapiens


      <400> 851
 Asp Gly Ser Ile Met Ala Ser Met Gln Lys Arg Leu Gln Lys Glu Leu
   1               5                  10                  15    
 Leu Ala Leu Gln Asn Asp Pro Pro Pro Gly Met Thr Leu Asn Glu Lys
              20                  25                  30        
 Ser Val Gln Asn Ser Ile Thr Gln Trp Ile Val Tyr Met Glu Gly Ala
          35                  40                  45            
 Pro Cys Thr Leu Tyr Glu Gly Glu Lys Phe Gln Leu Leu Phe Lys Cys
      50                  55                  60                
 Arg Arg Arg Tyr Pro Phe Asp Ser Ser Gln Gly Met Phe Thr Gly Glu
  65                  70                  75                  80
 Asn Ile Thr Asp His Pro His Val Tyr Ser Asn Gly His Met Cys Leu
                  85                  90                  95    
 Ser Ile Leu Thr Lys Asn Trp Phe Pro Ala Leu Ser Val Gln Ser Val
             100                 105                 110        
 Cys Leu Ser Ile Ile Ser Met Leu Ser Ser Cys Lys Glu Lys Thr Thr
         115                 120                 125            
 Asp His Pro Asp Asn Ser Phe Tyr Val Arg Thr Cys Asn Lys Asn Pro
     130                 135                 140                
 Lys Lys Thr Lys Trp Trp Tyr His Asp Asp Thr Cys
 145                 150                 155    



      <210> 852
      <211> 94
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(94)
      <223> Xaa = any amino acid or nothing 


      <400> 852
 Ala Ala Ala Glu Ala Lys Lys Ser Val Cys Arg Arg Leu Asp Tyr Ile
   1               5                  10                  15    
 Thr Gln Ser Leu Gln Gln Gln Gly Val Gln Ala Glu Asn Ile Thr Val
              20                  25                  30        
 Thr Lys Asp Phe Arg Arg Val Glu Asn Ala Tyr His Met Glu Ala Glu
          35                  40                  45            
 Lys Leu Leu Arg Arg Gly Gly Val Xaa Leu Xaa Ser Gln Leu Pro Gly
      50                  55                  60                
 Arg Leu Lys Gln Lys Lys Arg Ser Asn Leu Gly Gly Arg Ala Tyr Ser
  65                  70                  75                  80
 Glu Pro Arg Ser His His Cys Thr Ser Ala Trp Val Thr Lys
                  85                  90                



      <210> 853
      <211> 106
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(106)
      <223> Xaa = any amino acid or nothing 


      <400> 853
 Asn Thr Leu Pro Pro Trp Phe Xaa Leu Pro Ser Phe Ser Ala Ala Ala
   1               5                  10                  15    
 Ser Val Gln Arg Pro Pro Ala Pro Pro Ala Leu Ala Ser Pro Ser Thr
              20                  25                  30        
 Cys Pro Ala Ala Ser Ala Pro Ala Pro Ala Gly Cys Ala Arg Gly Arg
          35                  40                  45            
 Arg Ala Ala Ala Ala Cys Glu Ala Arg Pro Ala Leu Leu Pro Pro Pro
      50                  55                  60                
 Ala Pro Pro Ala Arg Arg Arg Arg Arg Pro Gly Ser Pro Arg Ala Leu
  65                  70                  75                  80
 Cys Ser Gly Ser Ala Arg Gly Arg Ser Gln Gly Arg Cys Ala Gly Thr
                  85                  90                  95    
 Gly Gly Gly Leu Cys Gly Met Trp Gly Pro
             100                 105    



      <210> 854
      <211> 106
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(106)
      <223> Xaa = any amino acid or nothing 


      <400> 854
 Asn Thr Leu Pro Pro Trp Phe Xaa Leu Pro Ser Phe Ser Ala Ala Ala
   1               5                  10                  15    
 Ser Val Gln Arg Pro Pro Ala Pro Pro Ala Leu Ala Ser Pro Ser Thr
              20                  25                  30        
 Cys Pro Ala Ala Ser Ala Pro Ala Pro Ala Gly Cys Ala Arg Gly Arg
          35                  40                  45            
 Arg Ala Ala Ala Ala Cys Glu Ala Arg Pro Ala Leu Leu Pro Pro Pro
      50                  55                  60                
 Ala Pro Pro Ala Arg Arg Arg Arg Arg Pro Gly Ser Pro Arg Ala Leu
  65                  70                  75                  80
 Cys Ser Gly Ser Ala Arg Gly Arg Ser Gln Gly Arg Cys Ala Gly Thr
                  85                  90                  95    
 Gly Gly Gly Leu Cys Gly Met Trp Gly Pro
             100                 105    



      <210> 855
      <211> 261
      <212> PRT
      <213> Homo sapiens


      <400> 855
 Gly Arg Val Gly Glu Ala Gln His Tyr Leu Ser Lys Thr Pro Glu Ser
   1               5                  10                  15    
 Ser Ala Gln Pro Ser Glu Thr Ile Leu Trp Asp Val Gln Thr Asp Ser
              20                  25                  30        
 Asn Pro Asn Gln Glu Lys Asp Ser Ser Ser Asn Glu Lys Gln Thr Ile
          35                  40                  45            
 Ser Leu Pro Val Ser Thr Ser Lys Ser Arg Lys Glu Ser Thr Glu Pro
      50                  55                  60                
 Lys Thr Cys Ile Glu Ser Met Glu Lys Lys Thr Asp Ser Leu Val Gln
  65                  70                  75                  80
 Asn Gly Asn Glu Arg Ser Asp Asp Thr Val Ser Asn Ile Ser Leu Ile
                  85                  90                  95    
 Asp Gln Lys Met Pro Asp Ile Glu Pro Asn Ser Glu Asn Asn Cys Ser
             100                 105                 110        
 Ser Ser Asp Ile Val Asn Gly His Ser Glu Ile Glu Gln Thr Pro Leu
         115                 120                 125            
 Val Ser Ser Asp Pro Ala Leu Lys Ile Asp Thr Asn Arg Ile Arg Thr
     130                 135                 140                
 Glu Asn Gly Ser Ile Leu Pro Ser Val Val Pro Gln Glu His Asn Thr
 145                 150                 155                 160
 Leu Pro Val Ser Gln Ala Pro Ser Lys Pro Asn Leu Thr Ser Glu His
                 165                 170                 175    
 Thr Ser Tyr Gly Leu Ile Leu Thr Lys Pro Tyr Val Arg Pro Leu Pro
             180                 185                 190        
 Pro Ser Tyr Leu Asp Glu Arg Tyr Leu Ser Met Pro Lys Arg Arg Lys
         195                 200                 205            
 Phe Leu Thr Asp Arg Val Asp Ala Cys Ser Asp Gln Asp Asn Val Tyr
     210                 215                 220                
 Lys Lys Ser Val Lys Arg Leu Arg Cys Gly Lys Cys Leu Thr Thr Tyr
 225                 230                 235                 240
 Cys Asn Ala Glu Ala Leu Glu Ala His Leu Ala Gln Lys Lys Cys Gln
                 245                 250                 255    
 Thr Leu Phe Gly Ile
             260    



      <210> 856
      <211> 199
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(199)
      <223> Xaa = any amino acid or nothing 


      <400> 856
 Pro Arg Val Arg Glu Arg Gly Val Ser Asp Ser Cys Cys Gln Gln Ala
   1               5                  10                  15    
 Pro Gly Gln Ser Glu Lys Glu Gly Gln Ile Pro Ser Asn Pro Ser Gly
              20                  25                  30        
 Ala Ser Xaa His Ser Leu Pro Met Pro Arg Cys Xaa Ala Thr Val Ser
          35                  40                  45            
 His Arg Ser Leu Cys Pro Glu Trp Pro Ala Pro Arg Pro Cys Asn Ser
      50                  55                  60                
 Pro Ser Pro Ser Pro Gln Glu Pro Pro Gln Pro Pro Pro Leu Trp Pro
  65                  70                  75                  80
 Leu Leu Gly Val Ile Leu Ala Pro Gln Asn Val Thr Trp Ser Val Trp
                  85                  90                  95    
 Cys Ala Gly Ser Pro Thr Ala Val Pro Gly Cys Pro Ser Cys Trp Pro
             100                 105                 110        
 Ala Ser Met Pro Ser Ala Pro Ser Ala Xaa Ser Ser Cys Cys Ala Cys
         115                 120                 125            
 Arg Thr Thr Pro Gly Pro Ser Pro Ala Arg Cys Ala Ala Arg Ser Pro
     130                 135                 140                
 Pro Ser Pro Gly Ala Ser Ser Ala Ala Cys Ala Thr Met Arg Arg Trp
 145                 150                 155                 160
 Trp Gly Ser Trp Pro Ser His Ala Gln Arg Tyr Arg Ser Val Leu Arg
                 165                 170                 175    
 Gly Trp Trp Ile Leu Leu Thr Trp Gln Gln Asp Thr Pro Ala Trp Trp
             180                 185                 190        
 Glu Arg Met Asp Arg Met Lys
         195                



      <210> 857
      <211> 269
      <212> PRT
      <213> Homo sapiens


      <400> 857
 Arg Val Leu Glu Leu Gln Pro Val Thr Leu Leu Leu Gly Asp His Gly
   1               5                  10                  15    
 Trp Val Glu His Val Asp Asn Gly Ile Arg Tyr Lys Leu Asp Val Thr
              20                  25                  30        
 Gln Cys Met Phe Ser Phe Gly Asn Ile Thr Glu Lys Leu Arg Val Ala
          35                  40                  45            
 Ser Leu Ser Cys Ala Gly Glu Val Leu Val Asp Leu Tyr Ala Gly Ile
      50                  55                  60                
 Gly Tyr Tyr Thr Leu Pro Phe Leu Val His Ala Gly Ala Ala Phe Val
  65                  70                  75                  80
 His Ala Cys Glu Trp Asn Pro His Ala Val Val Ala Leu Arg Asn Asn
                  85                  90                  95    
 Leu Glu Ile Asn Ala Val Ala Asp Arg Cys Gln Ile His Phe Gly Asp
             100                 105                 110        
 Asn Arg Lys Leu Lys Leu Ser Asn Ile Ala Asp Arg Val Ile Leu Gly
         115                 120                 125            
 Leu Ile Pro Ser Ser Glu Glu Gly Trp Pro Ile Ala Cys Gln Val Leu
     130                 135                 140                
 Arg Gln Asp Ala Gly Gly Ile Leu His Ile His Gln Asn Val Glu Ser
 145                 150                 155                 160
 Phe Pro Gly Lys Asn Leu Gln Ala Leu Gly Val Ser Lys Val Glu Lys
                 165                 170                 175    
 Glu His Trp Leu Tyr Pro Gln Gln Ile Thr Thr Asn Gln Trp Glu Lys
             180                 185                 190        
 Trp Glu Leu Pro Gly Ile Leu Gly Glu Lys Leu Leu Ser Pro Ala Thr
         195                 200                 205            
 Lys Pro Gln Leu Ala Lys Val Gly Arg Ile Cys Arg Asn Ser Asn Arg
     210                 215                 220                
 His Ser Ser Ser Ala Gly Ala Trp Glu Thr Met Glu Asp Thr Asn Ser
 225                 230                 235                 240
 Ala His Pro Thr Ser Glu Ile Leu Cys Ser Pro Cys Gly Ser His Ser
                 245                 250                 255    
 Pro Gly Ser Gly Met Leu Pro Leu Ser Phe Ser Trp Leu
             260                 265                



      <210> 858
      <211> 353
      <212> PRT
      <213> Homo sapiens


      <400> 858
 Ala Ser Arg Cys Val Ala Pro Gly Arg Gly Ala Pro Ala Ser Pro His
   1               5                  10                  15    
 Asp Val Asp Leu Cys Leu Val Ser Pro Cys Glu Phe Glu His Arg Lys
              20                  25                  30        
 Ala Val Pro Met Ala Pro Ala Pro Ala Ser Pro Gly Ser Ser Asn Asp
          35                  40                  45            
 Ser Ser Ala Arg Ser Gln Glu Arg Ala Gly Gly Leu Gly Ala Glu Glu
      50                  55                  60                
 Thr Pro Pro Thr Ser Val Ser Glu Ser Leu Pro Thr Leu Ser Asp Ser
  65                  70                  75                  80
 Asp Pro Asp Cys Pro Ser Ala Pro Gly Ala Ala Asp Ser Asp Glu Asp
                  85                  90                  95    
 Thr Glu Gly Phe Gly Val Pro Arg His Asp Pro Leu Pro Asp Pro Leu
             100                 105                 110        
 Lys Val Pro Pro Pro Leu Pro Asp Pro Ser Ser Ile Cys Met Val Asp
         115                 120                 125            
 Pro Glu Met Leu Pro Pro Lys Thr Ala Arg Gln Thr Glu Asn Val Ser
     130                 135                 140                
 Arg Thr Arg Lys Pro Leu Ala Arg Pro Asn Ser Arg Ala Ala Ala Pro
 145                 150                 155                 160
 Lys Ala Thr Pro Val Ala Ala Ala Lys Thr Lys Gly Leu Ala Gly Gly
                 165                 170                 175    
 Asp Arg Ala Ser Arg Pro Leu Ser Ala Arg Ser Glu Pro Ser Glu Lys
             180                 185                 190        
 Gly Gly Arg Ala Pro Leu Ser Arg Lys Ser Ser Thr Pro Lys Thr Ala
         195                 200                 205            
 Thr Arg Gly Pro Ser Gly Ser Ala Ser Ser Arg Pro Gly Val Ser Ala
     210                 215                 220                
 Thr Pro Pro Lys Val Pro Val Tyr Leu Asp Leu Ala Tyr Leu His Ser
 225                 230                 235                 240
 Gly Ser Ser Ala His Leu Val Asp Glu Glu Phe Phe Gln Arg Val Arg
                 245                 250                 255    
 Ala Leu Cys Tyr Val Ile Ser Gly Gln Asp Gln Arg Lys Glu Glu Gly
             260                 265                 270        
 Met Arg Ala Gly Pro Asp Ala Ala Thr Gly Gln Gln Ser Ser Ile Trp
         275                 280                 285            
 Asp Arg Asp Leu Gln Val Arg Val Thr Pro Gly Pro Leu Val Val Thr
     290                 295                 300                
 Leu Ile Pro Thr Phe Asp Ser Val Ala Met His Thr Trp Tyr Ala Glu
 305                 310                 315                 320
 Thr His Ala Arg His Gln Ala Leu Gly Ile Thr Val Leu Gly Ser Asn
                 325                 330                 335    
 Ser Met Val Ser Met Gln Asp Asp Ala Phe Pro Ala Cys Lys Val Glu
             340                 345                 350        
 Phe
    



      <210> 859
      <211> 247
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(247)
      <223> Xaa = any amino acid or nothing 


      <400> 859
 Phe Trp Ser Gly Pro Ala Leu Gly Pro Ser Pro Leu Ser Gly Glu Gly
   1               5                  10                  15    
 Asp Met Val Ala Thr Asp Glu Thr Val Cys Val Cys Ser Gly Cys Glu
              20                  25                  30        
 Gly Ala Pro Asp Pro Gly Ser Xaa Pro Gln Pro Ala Pro Asp Gln Arg
          35                  40                  45            
 Leu Gly Gln Cys Pro Val Trp Leu Pro Val Thr Xaa Pro Thr Ser Thr
      50                  55                  60                
 Arg Gly Thr Trp Thr Ala Ser Trp Pro Xaa Leu Thr Asp Ser Ser Val
  65                  70                  75                  80
 Thr Gly Pro Thr Ser Xaa Ser Leu Xaa Cys Ser Gly Arg Glu Lys Arg
                  85                  90                  95    
 Arg Gln Trp Ala Gln Pro Trp Thr Met Ala Thr Ser Asp Ser Ser Arg
             100                 105                 110        
 Thr Gly Gly Leu Pro Ala Ala Pro Ser Thr Ala Asp Ala Ser Arg Ala
         115                 120                 125            
 Arg Asp Val Pro Gly Ala Glu Ala Ala Pro Gly Val His Gly Leu Ala
     130                 135                 140                
 Ala Thr Ala Gly Cys Leu Cys Gln Gly Glu Pro Val Gly Pro His Val
 145                 150                 155                 160
 Ala Val Pro Val Gln Glu Ser Gly Ala Asp Pro Gln Pro Gln Asp Glu
                 165                 170                 175    
 Glu Glu Gly Pro Gln Pro Ala Gln Gly Pro Gly Cys Glu Gly Ala Glu
             180                 185                 190        
 Gly Lys Phe Pro Ser Ser Ser Ser Ala Thr Ser Val Ala Ala Pro Ser
         195                 200                 205            
 Gly Ser Ala Ser Cys Pro Ala Leu Ala Ala Thr Gly Ser Xaa Pro Ala
     210                 215                 220                
 Ala Ser Thr Ala Arg Pro Arg Pro Gly Pro Ser Ser Thr Arg Arg Thr
 225                 230                 235                 240
 Ala Gly Thr Trp Trp Pro Ser
                 245        



      <210> 860
      <211> 75
      <212> PRT
      <213> Homo sapiens


      <400> 860
 Lys Leu Ala Thr Pro Pro Ala Ala Gln Glu Ser Ser Arg Arg Arg Ser
   1               5                  10                  15    
 Arg Lys Gly His Leu Pro Ala Pro Val Gln Pro Tyr Glu His Gly Tyr
              20                  25                  30        
 Pro Val Ser Gly Gly Phe Ala Met Pro Pro Val Ser Leu Tyr His Ile
          35                  40                  45            
 Leu Thr Thr Ser Phe Ser Ser His Ala Val Asp Ile Ser Leu Asp Met
      50                  55                  60                
 Cys Cys Phe Ile Leu Leu Leu Pro Ser Leu Leu
  65                  70                  75



      <210> 861
      <211> 69
      <212> PRT
      <213> Homo sapiens


      <400> 861
 Lys Arg Arg Glu Glu Asn Arg Gly Gln Thr Leu Gln Phe Thr Asp Ala
   1               5                  10                  15    
 Ile Pro Asp Lys Met Pro Arg Ala Trp Pro Gly Ala Val Thr His Ala
              20                  25                  30        
 Cys Asn Pro Ser Thr Leu Gly Gly Arg Gly Arg Arg Met Thr Arg Ser
          35                  40                  45            
 Gly Asp Arg Asp His Arg Gly Gln His Gly Glu Thr Pro Ser Leu Leu
      50                  55                  60                
 Lys Ile Gln Lys Lys
  65                



      <210> 862
      <211> 275
      <212> PRT
      <213> Homo sapiens


      <400> 862
 Gln Lys Asn Thr His Tyr Met Met Ile Phe Asp Ala Phe Val Ile Leu
   1               5                  10                  15    
 Thr Cys Leu Val Ser Leu Ile Leu Cys Ile Arg Ser Val Ile Arg Gly
              20                  25                  30        
 Leu Gln Leu Gln Gln Glu Phe Val Asn Phe Phe Leu Leu His Tyr Lys
          35                  40                  45            
 Lys Glu Val Ser Val Ser Asp Gln Met Glu Phe Val Asn Gly Trp Tyr
      50                  55                  60                
 Ile Met Ile Ile Ile Ser Asp Ile Leu Thr Ile Ile Gly Ser Ile Leu
  65                  70                  75                  80
 Lys Met Glu Ile Gln Ala Lys Ser Leu Thr Ser Tyr Asp Val Cys Ser
                  85                  90                  95    
 Ile Leu Leu Gly Thr Ser Thr Met Leu Val Trp Leu Gly Val Ile Arg
             100                 105                 110        
 Tyr Leu Gly Phe Phe Ala Lys Tyr Asn Leu Leu Ile Leu Thr Leu Gln
         115                 120                 125            
 Ala Ala Leu Pro Asn Val Ile Arg Phe Cys Cys Cys Ala Ala Met Ile
     130                 135                 140                
 Tyr Leu Gly Tyr Cys Phe Cys Gly Trp Ile Val Leu Gly Pro Tyr His
 145                 150                 155                 160
 Asp Lys Phe Arg Ser Leu Asn Met Val Ser Glu Cys Leu Phe Ser Leu
                 165                 170                 175    
 Ile Asn Gly Asp Asp Met Phe Ala Thr Phe Ala Lys Met Gln Gln Lys
             180                 185                 190        
 Ser Tyr Leu Val Trp Leu Phe Ser Arg Ile Tyr Leu Tyr Ser Phe Ile
         195                 200                 205            
 Ser Leu Phe Ile Tyr Met Ile Leu Ser Leu Phe Ile Ala Leu Ile Thr
     210                 215                 220                
 Asp Thr Tyr Glu Thr Ile Lys Gln Tyr Gln Gln Asp Gly Phe Pro Glu
 225                 230                 235                 240
 Thr Glu Leu Arg Thr Phe Ile Ser Glu Cys Lys Asp Leu Pro Asn Ser
                 245                 250                 255    
 Gly Lys Tyr Arg Leu Glu Asp Asp Pro Pro Val Ser Leu Phe Cys Cys
             260                 265                 270        
 Cys Lys Lys
         275



      <210> 863
      <211> 116
      <212> PRT
      <213> Homo sapiens


      <400> 863
 Pro Cys Cys Ser His Pro Asn Ala Val Leu Gly Val Gln Gln Thr Leu
   1               5                  10                  15    
 Glu Glu Met Asp Phe Gln Arg Gly Ile Trp Ser Ala Ala Leu Asn Gly
              20                  25                  30        
 Asp Leu Gly Arg Val Lys His Leu Ile Gln Lys Ala Glu Asp Pro Ser
          35                  40                  45            
 Gln Pro Asp Ser Ala Gly Tyr Thr Ala Leu His Tyr Ala Ser Arg Asn
      50                  55                  60                
 Gly His Tyr Ala Val Cys Gln Phe Leu Leu Glu Ser Gly Ala Lys Cys
  65                  70                  75                  80
 Asp Ala Gln Thr His Gly Gly Ala Thr Ala Leu His Arg Ala Ser Tyr
                  85                  90                  95    
 Cys Gly His Thr Glu Ile Gly Arg Leu Leu Leu Ser His Gly Ser Asn
             100                 105                 110        
 Pro Lys Val Gly
         115    



      <210> 864
      <211> 116
      <212> PRT
      <213> Homo sapiens


      <400> 864
 Pro Cys Cys Ser His Pro Asn Ala Val Leu Gly Val Gln Gln Thr Leu
   1               5                  10                  15    
 Glu Glu Met Asp Phe Gln Arg Gly Ile Trp Ser Ala Ala Leu Asn Gly
              20                  25                  30        
 Asp Leu Gly Arg Val Lys His Leu Ile Gln Lys Ala Glu Asp Pro Ser
          35                  40                  45            
 Gln Pro Asp Ser Ala Gly Tyr Thr Ala Leu His Tyr Ala Ser Arg Asn
      50                  55                  60                
 Gly His Tyr Ala Val Cys Gln Phe Leu Leu Glu Ser Gly Ala Lys Cys
  65                  70                  75                  80
 Asp Ala Gln Thr His Gly Gly Ala Thr Ala Leu His Arg Ala Ser Tyr
                  85                  90                  95    
 Cys Gly His Thr Glu Ile Gly Arg Leu Leu Leu Ser His Gly Ser Asn
             100                 105                 110        
 Pro Lys Val Gly
         115    


